TNFRSF6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.15959386
2citrulline biosynthetic process (GO:0019240)6.49419267
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.48540957
4desmosome organization (GO:0002934)5.02082455
5positive regulation of pseudopodium assembly (GO:0031274)4.81776914
6renal filtration (GO:0097205)4.70214378
7activation of Rac GTPase activity (GO:0032863)4.65441521
8citrulline metabolic process (GO:0000052)4.63295270
9positive regulation of Cdc42 GTPase activity (GO:0043089)4.57559133
10membrane raft organization (GO:0031579)4.36414879
11regulation of pseudopodium assembly (GO:0031272)4.26135058
12negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.19594590
13regulation of metalloenzyme activity (GO:0048552)4.11691612
14positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.05546873
15negative regulation of protein tyrosine kinase activity (GO:0061099)3.89884901
16GDP-mannose metabolic process (GO:0019673)3.78655376
17branching involved in salivary gland morphogenesis (GO:0060445)3.62634437
18regulation of respiratory burst (GO:0060263)3.53109824
19regulation of apoptotic process involved in morphogenesis (GO:1902337)3.51805647
20branching involved in mammary gland duct morphogenesis (GO:0060444)3.42870316
21protein retention in ER lumen (GO:0006621)3.41341854
22endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.38078960
23glycosphingolipid catabolic process (GO:0046479)3.35326764
24glomerular filtration (GO:0003094)3.34053300
25muscle cell migration (GO:0014812)3.33440360
26peptidyl-arginine modification (GO:0018195)3.31356005
27keratinocyte proliferation (GO:0043616)3.28069083
28cell-substrate junction assembly (GO:0007044)3.23317641
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23285125
30barbed-end actin filament capping (GO:0051016)3.22689461
31diterpenoid biosynthetic process (GO:0016102)3.21305075
32negative regulation of nitric oxide biosynthetic process (GO:0045019)3.19433097
33regulation of viral release from host cell (GO:1902186)3.17843699
34NIK/NF-kappaB signaling (GO:0038061)3.17626097
35negative regulation of viral release from host cell (GO:1902187)3.16850029
36protein localization to endosome (GO:0036010)3.14317668
37regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.13409683
38complement activation, classical pathway (GO:0006958)3.09801020
39cell differentiation involved in embryonic placenta development (GO:0060706)3.07108890
40chronic inflammatory response (GO:0002544)3.05908442
41response to progesterone (GO:0032570)3.05419190
42glycolipid catabolic process (GO:0019377)3.01765142
43positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.95887084
44semaphorin-plexin signaling pathway (GO:0071526)2.95175549
45positive regulation of respiratory burst (GO:0060267)2.93488267
46myeloid dendritic cell differentiation (GO:0043011)2.92128044
47positive regulation of protein localization to plasma membrane (GO:1903078)2.91581214
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.90500451
49mesodermal cell differentiation (GO:0048333)2.87970953
50COPI coating of Golgi vesicle (GO:0048205)2.86423534
51Golgi transport vesicle coating (GO:0048200)2.86423534
52lung vasculature development (GO:0060426)2.77935659
53endothelial cell chemotaxis (GO:0035767)2.77905564
54regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77120330
55endothelial cell morphogenesis (GO:0001886)2.76795699
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75675938
57positive regulation of extracellular matrix organization (GO:1903055)2.75403370
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73794281
59apoptotic process involved in morphogenesis (GO:0060561)2.70924100
60activation of MAPKKK activity (GO:0000185)2.69400437
61eosinophil chemotaxis (GO:0048245)2.69042678
62apoptotic cell clearance (GO:0043277)2.68719625
63cell adhesion mediated by integrin (GO:0033627)2.68063537
64germinal center formation (GO:0002467)2.67893205
65regulation of integrin activation (GO:0033623)2.67212688
66regulation of glucose import in response to insulin stimulus (GO:2001273)2.67121782
67pyrimidine nucleoside salvage (GO:0043097)2.64089055
68pyrimidine-containing compound salvage (GO:0008655)2.64089055
69mammary gland epithelial cell proliferation (GO:0033598)2.63577819
70cyclooxygenase pathway (GO:0019371)2.62097080
71negative regulation of viral entry into host cell (GO:0046597)2.61222507
72diaphragm development (GO:0060539)2.60167589
73regulation of cytokine secretion involved in immune response (GO:0002739)2.59447186
74regulation of vitamin D biosynthetic process (GO:0060556)2.59354534
75regulation of necrotic cell death (GO:0010939)2.58728335
76positive regulation of histone acetylation (GO:0035066)2.57591435
77endocytic recycling (GO:0032456)2.55910772
78response to manganese ion (GO:0010042)2.55594338
79response to peptidoglycan (GO:0032494)2.54747050
80regulation of vitamin metabolic process (GO:0030656)2.54601411
81fibrinolysis (GO:0042730)2.52529784
82ceramide catabolic process (GO:0046514)2.51847492
83positive regulation of receptor recycling (GO:0001921)2.50179556
84negative regulation of nitric-oxide synthase activity (GO:0051001)2.50086108
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49379666
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47489100
87response to type I interferon (GO:0034340)2.47274368
88antimicrobial humoral response (GO:0019730)2.46632779
89defense response to protozoan (GO:0042832)2.45902306
90negative regulation of anoikis (GO:2000811)2.45407743
91regulation of cellular extravasation (GO:0002691)2.44847011
92response to protozoan (GO:0001562)2.44040995
93glutathione biosynthetic process (GO:0006750)2.41396082
94regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41014562
95bone remodeling (GO:0046849)2.40027002
96positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.37912716
97bundle of His cell to Purkinje myocyte communication (GO:0086069)2.37796733
98regulation of histone phosphorylation (GO:0033127)2.37260654
99leukocyte apoptotic process (GO:0071887)2.37135772
100type I interferon signaling pathway (GO:0060337)2.36240183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.60700966
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87592253
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.91009569
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.07368260
5ZNF263_19887448_ChIP-Seq_K562_Human2.99942996
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84911028
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.48224068
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.43680045
9* LXR_22292898_ChIP-Seq_THP-1_Human2.42383139
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41938564
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18107965
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.17607033
13RACK7_27058665_Chip-Seq_MCF-7_Human2.11590768
14KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.04145589
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92089178
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.86364741
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80761142
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79140233
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.78124530
20VDR_21846776_ChIP-Seq_THP-1_Human1.77795946
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77396073
22* ATF3_27146783_Chip-Seq_COLON_Human1.75209676
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67073090
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67073090
25UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66040180
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64875547
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.63330619
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54172384
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.53702966
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.51827118
31SOX2_20726797_ChIP-Seq_SW620_Human1.51579081
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.51359113
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49228211
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47037710
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44586862
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44054783
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44009405
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43930037
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43533103
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41933978
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36782777
42P68_20966046_ChIP-Seq_HELA_Human1.35700047
43CLOCK_20551151_ChIP-Seq_293T_Human1.35452002
44HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33648248
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32046784
46BCL6_27268052_Chip-Seq_Bcells_Human1.31232247
47* SMC4_20622854_ChIP-Seq_HELA_Human1.30624856
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.29325321
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29222169
50SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27670529
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27401921
52BCOR_27268052_Chip-Seq_Bcells_Human1.26179503
53VDR_24763502_ChIP-Seq_THP-1_Human1.26145822
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.24723393
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.22139080
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21457627
57* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19704525
58TP53_22127205_ChIP-Seq_IMR90_Human1.17988475
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17956843
60KDM2B_26808549_Chip-Seq_K562_Human1.16540305
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16440637
62* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15649038
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15589002
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.15427668
65TCF7_22412390_ChIP-Seq_EML_Mouse1.14509480
66KLF5_25053715_ChIP-Seq_YYC3_Human1.12180701
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.11932250
68TP63_22573176_ChIP-Seq_HFKS_Human1.10677366
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09909261
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09701820
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09347975
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09130909
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08897707
74SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08496197
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07786331
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06856809
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.04514389
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03825664
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03136103
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02944347
81GATA6_25053715_ChIP-Seq_YYC3_Human1.02683950
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00620378
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00538881
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99750458
85CTCF_27219007_Chip-Seq_Bcells_Human0.99648070
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99073103
87* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98861534
88RARA_24833708_ChIP-Seq_LIVER_Mouse0.98231268
89BP1_19119308_ChIP-ChIP_Hs578T_Human0.97376535
90SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96748344
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96679933
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95994071
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95174938
94* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95125902
95KDM2B_26808549_Chip-Seq_DND41_Human0.95040340
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94050128
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92822829
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92724320
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92635192
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91088484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.85072378
2MP0003453_abnormal_keratinocyte_physiol2.95787142
3MP0003191_abnormal_cellular_cholesterol2.88596340
4MP0003705_abnormal_hypodermis_morpholog2.77660612
5MP0005023_abnormal_wound_healing2.54099189
6MP0004264_abnormal_extraembryonic_tissu2.49262540
7MP0002877_abnormal_melanocyte_morpholog2.43801159
8MP0004858_abnormal_nervous_system2.42736599
9MP0003566_abnormal_cell_adhesion2.21431133
10MP0003436_decreased_susceptibility_to2.19991650
11MP0004272_abnormal_basement_membrane2.16321685
12MP0000858_altered_metastatic_potential2.13529668
13MP0003806_abnormal_nucleotide_metabolis2.11458244
14MP0004947_skin_inflammation2.09311571
15MP0003075_altered_response_to2.04456643
16MP0005083_abnormal_biliary_tract2.02094606
17MP0009840_abnormal_foam_cell2.01416294
18MP0001849_ear_inflammation2.00839584
19MP0003303_peritoneal_inflammation1.99754599
20MP0004510_myositis1.91925677
21MP0002796_impaired_skin_barrier1.91718259
22MP0005058_abnormal_lysosome_morphology1.88853717
23MP0005166_decreased_susceptibility_to1.83352408
24MP0005360_urolithiasis1.79714958
25MP0000343_altered_response_to1.78692363
26MP0002148_abnormal_hypersensitivity_rea1.78624459
27MP0010352_gastrointestinal_tract_polyps1.73613990
28MP0010155_abnormal_intestine_physiology1.71613035
29MP0000678_abnormal_parathyroid_gland1.68003049
30MP0009764_decreased_sensitivity_to1.64775903
31MP0005164_abnormal_response_to1.64441407
32MP0001216_abnormal_epidermal_layer1.61011731
33MP0001873_stomach_inflammation1.57262092
34MP0003448_altered_tumor_morphology1.56816733
35MP0001853_heart_inflammation1.54068398
36MP0005451_abnormal_body_composition1.51793862
37MP0005501_abnormal_skin_physiology1.49951968
38MP0001533_abnormal_skeleton_physiology1.49299054
39MP0009785_altered_susceptibility_to1.48672778
40MP0006082_CNS_inflammation1.46543321
41MP0000467_abnormal_esophagus_morphology1.45924764
42MP0000762_abnormal_tongue_morphology1.41359647
43MP0000537_abnormal_urethra_morphology1.40208112
44MP0002933_joint_inflammation1.40177469
45MP0003950_abnormal_plasma_membrane1.39835241
46MP0004185_abnormal_adipocyte_glucose1.39144022
47MP0003724_increased_susceptibility_to1.38281149
48MP0005025_abnormal_response_to1.37990940
49MP0002332_abnormal_exercise_endurance1.37137496
50MP0002060_abnormal_skin_morphology1.35302631
51MP0003329_amyloid_beta_deposits1.27892434
52MP0008260_abnormal_autophagy1.24405971
53MP0000750_abnormal_muscle_regeneration1.20424964
54MP0002419_abnormal_innate_immunity1.20254996
55MP0003300_gastrointestinal_ulcer1.17498136
56MP0005257_abnormal_intraocular_pressure1.16614883
57MP0005076_abnormal_cell_differentiation1.12186436
58MP0000579_abnormal_nail_morphology1.11381171
59MP0002139_abnormal_hepatobiliary_system1.10924051
60MP0005666_abnormal_adipose_tissue1.10877457
61MP0003091_abnormal_cell_migration1.09650016
62MP0005387_immune_system_phenotype1.08811262
63MP0001790_abnormal_immune_system1.08811262
64MP0001663_abnormal_digestive_system1.07555975
65MP0004782_abnormal_surfactant_physiolog1.07523558
66MP0005595_abnormal_vascular_smooth1.06930218
67MP0000566_synostosis1.05617698
68MP0004019_abnormal_vitamin_homeostasis1.05204630
69MP0000685_abnormal_immune_system1.04817547
70MP0005670_abnormal_white_adipose1.03790479
71MP0001664_abnormal_digestion1.03320255
72MP0005165_increased_susceptibility_to1.03166705
73MP0003045_fibrosis1.02746790
74MP0002998_abnormal_bone_remodeling1.01383091
75MP0002138_abnormal_hepatobiliary_system0.99502358
76MP0004883_abnormal_blood_vessel0.98544662
77MP0000681_abnormal_thyroid_gland0.98541813
78MP0005390_skeleton_phenotype0.95829098
79MP0009379_abnormal_foot_pigmentation0.95053209
80MP0000733_abnormal_muscle_development0.94914796
81MP0010030_abnormal_orbit_morphology0.94511504
82MP0001845_abnormal_inflammatory_respons0.92338603
83MP0010771_integument_phenotype0.92157859
84MP0009278_abnormal_bone_marrow0.91986868
85MP0000249_abnormal_blood_vessel0.89854383
86MP0002896_abnormal_bone_mineralization0.89000285
87MP0005381_digestive/alimentary_phenotyp0.87798798
88MP0000604_amyloidosis0.87668311
89MP0001542_abnormal_bone_strength0.87253007
90MP0002098_abnormal_vibrissa_morphology0.86515001
91MP0005409_darkened_coat_color0.85544322
92MP0005623_abnormal_meninges_morphology0.81847468
93MP0005375_adipose_tissue_phenotype0.81223172
94MP0001881_abnormal_mammary_gland0.80732770
95MP0002452_abnormal_antigen_presenting0.80233620
96MP0009780_abnormal_chondrocyte_physiolo0.80011055
97MP0003315_abnormal_perineum_morphology0.79373426
98MP0008469_abnormal_protein_level0.78952187
99MP0003828_pulmonary_edema0.78590868
100MP0000477_abnormal_intestine_morphology0.77380641

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)4.66061045
2Milia (HP:0001056)4.44736482
3Axonal loss (HP:0003447)4.35268445
4Alopecia of scalp (HP:0002293)4.28696369
5Atrophic scars (HP:0001075)4.28254257
6Focal segmental glomerulosclerosis (HP:0000097)4.04821183
7Plantar hyperkeratosis (HP:0007556)3.84723666
8Glomerulosclerosis (HP:0000096)3.82503870
9Distal upper limb amyotrophy (HP:0007149)3.80333601
10Upper limb amyotrophy (HP:0009129)3.80333601
11Fragile skin (HP:0001030)3.47492967
12Interstitial pulmonary disease (HP:0006530)3.46978930
13Abnormal blistering of the skin (HP:0008066)3.46671837
14Abnormality of glycolipid metabolism (HP:0010969)3.46287116
15Abnormality of liposaccharide metabolism (HP:0010968)3.46287116
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.46287116
17Onycholysis (HP:0001806)3.42040546
18Distal lower limb amyotrophy (HP:0008944)3.39902106
19Nail dystrophy (HP:0008404)3.05937539
20Protrusio acetabuli (HP:0003179)3.05485356
21Pterygium (HP:0001059)2.88749862
22Neurofibrillary tangles (HP:0002185)2.85864145
23Cheilitis (HP:0100825)2.83501090
24Systemic lupus erythematosus (HP:0002725)2.71834768
25Deep venous thrombosis (HP:0002625)2.71001736
26Ridged nail (HP:0001807)2.66752522
27Right ventricular cardiomyopathy (HP:0011663)2.63238648
28Arterial tortuosity (HP:0005116)2.62971422
29Reduced subcutaneous adipose tissue (HP:0003758)2.62636013
30Polygenic inheritance (HP:0010982)2.61432143
31Diaphragmatic weakness (HP:0009113)2.61300675
32Thick nail (HP:0001805)2.58695204
33Trismus (HP:0000211)2.57806260
34Pustule (HP:0200039)2.41289145
35Palmoplantar hyperkeratosis (HP:0000972)2.39155904
36Malnutrition (HP:0004395)2.37272069
37Premature loss of primary teeth (HP:0006323)2.34206100
38Abnormality of the nasal mucosa (HP:0000433)2.33463524
39Selective tooth agenesis (HP:0001592)2.33285296
40Premature rupture of membranes (HP:0001788)2.33007003
41Abnormal hair laboratory examination (HP:0003328)2.30604321
42Vascular tortuosity (HP:0004948)2.29926022
43Acanthosis nigricans (HP:0000956)2.28283958
44Hemorrhage of the eye (HP:0011885)2.24801257
45Nuclear cataract (HP:0100018)2.22749570
46Short nail (HP:0001799)2.19508411
47Lower limb amyotrophy (HP:0007210)2.18700761
48Hypoplasia of dental enamel (HP:0006297)2.18696509
49Generalized amyotrophy (HP:0003700)2.18319491
50Abnormality of complement system (HP:0005339)2.17155610
51Difficulty climbing stairs (HP:0003551)2.17119507
52Cerebral inclusion bodies (HP:0100314)2.16431115
53Erythema (HP:0010783)2.12203619
54Growth hormone excess (HP:0000845)2.10235236
55Coxa vara (HP:0002812)2.09573684
56Palmar hyperkeratosis (HP:0010765)2.09395063
57Pili torti (HP:0003777)2.07575205
58Gout (HP:0001997)2.01750643
59Hypokinesia (HP:0002375)1.99901572
60Aplasia cutis congenita (HP:0001057)1.99494182
61Thin bony cortex (HP:0002753)1.99403246
62Ankyloglossia (HP:0010296)1.99380482
63Cervical subluxation (HP:0003308)1.98645521
64Glucose intolerance (HP:0000833)1.98536440
65Increased connective tissue (HP:0009025)1.97905436
66Hyperacusis (HP:0010780)1.95418312
67Stridor (HP:0010307)1.95222725
68Supranuclear gaze palsy (HP:0000605)1.93868623
69Vertebral compression fractures (HP:0002953)1.93223977
70Loss of speech (HP:0002371)1.92527511
71Vascular calcification (HP:0004934)1.91842850
72Abnormality of placental membranes (HP:0011409)1.91043323
73Amniotic constriction ring (HP:0009775)1.91043323
74Bulbar palsy (HP:0001283)1.90615146
75Hyperparathyroidism (HP:0000843)1.89991017
76Bone pain (HP:0002653)1.89042935
77Broad face (HP:0000283)1.88812122
78Joint stiffness (HP:0001387)1.86376889
79Mildly elevated creatine phosphokinase (HP:0008180)1.84629644
80Hyperuricemia (HP:0002149)1.83368113
81Increased purine levels (HP:0004368)1.83368113
82Rough bone trabeculation (HP:0100670)1.81839886
83Dysostosis multiplex (HP:0000943)1.81314540
84Amyloidosis (HP:0011034)1.79758047
85Hand muscle atrophy (HP:0009130)1.79662915
86Dysautonomia (HP:0002459)1.78693301
87Polar cataract (HP:0010696)1.76941720
88Spinal cord compression (HP:0002176)1.76782142
89Nasal polyposis (HP:0100582)1.75611432
90Insulin resistance (HP:0000855)1.74921763
91Hepatosplenomegaly (HP:0001433)1.74413092
92Autoimmune thrombocytopenia (HP:0001973)1.73613353
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71768227
94Abnormality of macrophages (HP:0004311)1.71649338
95Achilles tendon contracture (HP:0001771)1.71148592
96Abnormal autonomic nervous system physiology (HP:0012332)1.70535166
97Neonatal death (HP:0003811)1.70367682
98Distal lower limb muscle weakness (HP:0009053)1.69355895
99Abnormality of nail color (HP:0100643)1.69119594
100Multifactorial inheritance (HP:0001426)1.68037681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.82505603
2EPHA27.73800432
3MET4.19898625
4ERN13.33978707
5EPHB23.19869188
6NME23.10154845
7IRAK32.56935070
8LMTK22.40600648
9SIK12.04919302
10RIPK12.04804986
11TRIB32.02692161
12EPHB11.86731615
13NTRK11.84602482
14PTK21.83823281
15BMX1.66049244
16PAK41.50451234
17PDGFRA1.47969894
18PTK61.44411926
19FLT31.38003398
20TAOK21.19960657
21TESK11.19773048
22ZAP701.11707367
23ARAF1.10029600
24PIM21.06770334
25TBK11.05364314
26ABL21.04317193
27TGFBR20.97945506
28LIMK10.97924388
29MAP3K140.97598410
30PRKG20.95490199
31MOS0.94549114
32MAP3K30.92161064
33CDK80.88180648
34SMG10.86251321
35MAP3K110.84772840
36DDR20.82349343
37PRPF4B0.82335265
38MAP3K130.80235844
39MST40.79831588
40CDC42BPA0.72789253
41MAP3K90.71295657
42JAK30.66147463
43TYK20.63450408
44VRK20.61526273
45BRAF0.60388453
46PKN20.56470851
47TAOK10.54684925
48PDGFRB0.52690247
49PRKD20.52280026
50FGFR40.51796923
51ICK0.49537771
52STK100.48547070
53CSF1R0.48489876
54MAP3K10.46624220
55PRKCI0.46531799
56MAP3K80.45856378
57MAP2K30.45475522
58IKBKB0.44669643
59GRK50.43982540
60DMPK0.42708447
61MUSK0.42227049
62PTK2B0.40598261
63MAP4K10.39938431
64LRRK20.39176629
65MAP2K60.34720111
66LATS20.34674490
67NEK10.34391660
68STK160.33308119
69GRK70.31230248
70HIPK20.31226097
71IRAK40.29757305
72TESK20.29739981
73MAP3K20.29454997
74SRC0.29357941
75FER0.29306162
76MAP3K120.28209661
77PDPK10.26929710
78NME10.26566615
79SIK30.26424988
80ILK0.26417197
81CAMK2G0.26016795
82IKBKE0.24368491
83CHUK0.24223461
84MAP3K70.23662169
85MELK0.23542111
86KSR10.23147442
87MATK0.22813128
88CSK0.22716519
89ERBB40.22624264
90PAK10.22493558
91ROCK20.20879630
92JAK10.20456617
93MAP2K20.20287290
94PHKG20.19114208
95PHKG10.19114208
96CAMK2B0.17976478
97IRAK10.17483372
98IGF1R0.15672767
99CAMK2D0.15425072
100PRKCD0.15221716

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.81119257
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64520449
3Other glycan degradation_Homo sapiens_hsa005112.44238496
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.24081272
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14483371
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.13710180
7Fructose and mannose metabolism_Homo sapiens_hsa000512.01412226
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95996724
9TNF signaling pathway_Homo sapiens_hsa046681.92865281
10Galactose metabolism_Homo sapiens_hsa000521.87476339
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86470338
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.74905288
13Salmonella infection_Homo sapiens_hsa051321.74397568
14Arginine biosynthesis_Homo sapiens_hsa002201.70344220
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.68443236
16Pertussis_Homo sapiens_hsa051331.67462867
17Toxoplasmosis_Homo sapiens_hsa051451.67356819
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65002481
19African trypanosomiasis_Homo sapiens_hsa051431.50364502
20Lysosome_Homo sapiens_hsa041421.46760450
21Shigellosis_Homo sapiens_hsa051311.45830135
22Asthma_Homo sapiens_hsa053101.45629323
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43453656
24Prion diseases_Homo sapiens_hsa050201.40337751
25ECM-receptor interaction_Homo sapiens_hsa045121.39958800
26Malaria_Homo sapiens_hsa051441.37337183
27Hepatitis C_Homo sapiens_hsa051601.37255546
28Leishmaniasis_Homo sapiens_hsa051401.36892186
29Bladder cancer_Homo sapiens_hsa052191.35778622
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.30526322
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28471692
32Amoebiasis_Homo sapiens_hsa051461.27356454
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.24710715
34Influenza A_Homo sapiens_hsa051641.24555046
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.23755571
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20465501
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19723324
38Rheumatoid arthritis_Homo sapiens_hsa053231.18988133
39Osteoclast differentiation_Homo sapiens_hsa043801.18062171
40Legionellosis_Homo sapiens_hsa051341.16623090
41Sphingolipid metabolism_Homo sapiens_hsa006001.15964637
42Phenylalanine metabolism_Homo sapiens_hsa003601.14601302
43Proteasome_Homo sapiens_hsa030501.08876278
44Vibrio cholerae infection_Homo sapiens_hsa051101.08571806
45Small cell lung cancer_Homo sapiens_hsa052221.06100457
46Chronic myeloid leukemia_Homo sapiens_hsa052201.05085689
47Focal adhesion_Homo sapiens_hsa045101.03790060
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01802090
49Folate biosynthesis_Homo sapiens_hsa007901.00385223
50Apoptosis_Homo sapiens_hsa042100.98694018
51Mineral absorption_Homo sapiens_hsa049780.98255333
52Allograft rejection_Homo sapiens_hsa053300.97847038
53Sulfur relay system_Homo sapiens_hsa041220.97683455
54Staphylococcus aureus infection_Homo sapiens_hsa051500.96989848
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95273561
56* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94708550
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93301796
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91938482
59Tuberculosis_Homo sapiens_hsa051520.91175722
60Proteoglycans in cancer_Homo sapiens_hsa052050.89980248
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88599632
62N-Glycan biosynthesis_Homo sapiens_hsa005100.87196137
63Viral myocarditis_Homo sapiens_hsa054160.87073672
64Complement and coagulation cascades_Homo sapiens_hsa046100.86837812
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.85017272
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83977920
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83255576
68Pancreatic cancer_Homo sapiens_hsa052120.80801770
69Vitamin B6 metabolism_Homo sapiens_hsa007500.80760365
70Endocytosis_Homo sapiens_hsa041440.80096177
71Glutathione metabolism_Homo sapiens_hsa004800.79547160
72Notch signaling pathway_Homo sapiens_hsa043300.78499003
73Antigen processing and presentation_Homo sapiens_hsa046120.77224596
74Renin-angiotensin system_Homo sapiens_hsa046140.76498080
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76457798
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75972322
77VEGF signaling pathway_Homo sapiens_hsa043700.74047724
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69984792
79Graft-versus-host disease_Homo sapiens_hsa053320.68419041
80Autoimmune thyroid disease_Homo sapiens_hsa053200.68163706
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.67288653
82Pentose phosphate pathway_Homo sapiens_hsa000300.65281829
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.64403707
84Fat digestion and absorption_Homo sapiens_hsa049750.62912013
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61752512
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57674308
87Axon guidance_Homo sapiens_hsa043600.54019740
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48831617
89Phagosome_Homo sapiens_hsa041450.48130093
90Arginine and proline metabolism_Homo sapiens_hsa003300.46757232
91Adherens junction_Homo sapiens_hsa045200.44882701
92Acute myeloid leukemia_Homo sapiens_hsa052210.44718982
93Hematopoietic cell lineage_Homo sapiens_hsa046400.43901118
94Pyrimidine metabolism_Homo sapiens_hsa002400.42361778
95HTLV-I infection_Homo sapiens_hsa051660.40531043
96Arachidonic acid metabolism_Homo sapiens_hsa005900.39423562
97Tight junction_Homo sapiens_hsa045300.38052803
98Protein digestion and absorption_Homo sapiens_hsa049740.37654162
99Tyrosine metabolism_Homo sapiens_hsa003500.36230519
100Renal cell carcinoma_Homo sapiens_hsa052110.35569605

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