TNFRSF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of podosome assembly (GO:0071801)6.24624168
2tolerance induction (GO:0002507)5.81485699
3antigen processing and presentation of endogenous antigen (GO:0019883)5.62039972
4positive regulation of granulocyte differentiation (GO:0030854)5.31996466
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.09239782
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.09239782
7positive regulation of gamma-delta T cell activation (GO:0046645)5.07385214
8regulation of immunoglobulin secretion (GO:0051023)4.76829384
9NIK/NF-kappaB signaling (GO:0038061)4.68076338
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.61996339
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.59590210
12response to interleukin-15 (GO:0070672)4.46232003
13negative T cell selection (GO:0043383)4.45160633
14B cell receptor signaling pathway (GO:0050853)4.40827489
15negative thymic T cell selection (GO:0045060)4.30227453
16positive regulation of immunoglobulin production (GO:0002639)4.24722844
17positive regulation of macrophage activation (GO:0043032)4.20607143
18negative regulation of interleukin-12 production (GO:0032695)4.14425797
19leukocyte aggregation (GO:0070486)4.08102794
20positive regulation of B cell proliferation (GO:0030890)3.99557604
21detection of bacterium (GO:0016045)3.92150801
22cellular response to interleukin-15 (GO:0071350)3.92129759
23T-helper 1 type immune response (GO:0042088)3.91630665
24type I interferon signaling pathway (GO:0060337)3.88774048
25cellular response to type I interferon (GO:0071357)3.88774048
26response to type I interferon (GO:0034340)3.86279560
27regulation of gamma-delta T cell differentiation (GO:0045586)3.82935611
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.82479108
29B cell homeostasis (GO:0001782)3.80898769
30detection of other organism (GO:0098543)3.77068738
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.77034553
32positive thymic T cell selection (GO:0045059)3.75431300
33regulation of gamma-delta T cell activation (GO:0046643)3.74550625
34regulation of immunoglobulin production (GO:0002637)3.72860823
35thymic T cell selection (GO:0045061)3.69124372
36tyrosine phosphorylation of STAT protein (GO:0007260)3.66897513
37T cell migration (GO:0072678)3.65364007
38immunoglobulin mediated immune response (GO:0016064)3.62879712
39T cell selection (GO:0045058)3.61695155
40T cell lineage commitment (GO:0002360)3.58656182
41regulation of interferon-beta biosynthetic process (GO:0045357)3.56203885
42positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.50647332
43positive regulation of humoral immune response (GO:0002922)3.49893162
44positive regulation of interferon-alpha production (GO:0032727)3.49144175
45response to host immune response (GO:0052572)3.45247779
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45247779
47regulation of B cell proliferation (GO:0030888)3.44105938
48positive T cell selection (GO:0043368)3.39844037
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.35822626
50regulation of granulocyte differentiation (GO:0030852)3.33366278
51macrophage activation involved in immune response (GO:0002281)3.29912730
52positive regulation of B cell activation (GO:0050871)3.29336224
53B cell mediated immunity (GO:0019724)3.24922282
54B cell proliferation (GO:0042100)3.24465564
55positive regulation of interleukin-2 production (GO:0032743)3.22165055
56positive regulation by symbiont of host defense response (GO:0052509)3.20986027
57modulation by symbiont of host defense response (GO:0052031)3.20986027
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20986027
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20986027
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.20986027
61modulation by symbiont of host immune response (GO:0052553)3.20986027
62T-helper cell differentiation (GO:0042093)3.19620905
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.19620905
64regulation of chronic inflammatory response (GO:0002676)3.17233761
65myeloid dendritic cell differentiation (GO:0043011)3.16358187
66regulation of B cell differentiation (GO:0045577)3.15105761
67regulation of interferon-gamma biosynthetic process (GO:0045072)3.14510924
68response to host (GO:0075136)3.14043280
69response to host defenses (GO:0052200)3.14043280
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14043280
71cellular response to interferon-gamma (GO:0071346)3.12988598
72positive regulation of B cell mediated immunity (GO:0002714)3.09898000
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.09898000
74regulation of interleukin-12 biosynthetic process (GO:0045075)3.09050779
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06188084
76positive regulation of production of molecular mediator of immune response (GO:0002702)3.04896342
77myeloid dendritic cell activation (GO:0001773)2.97958488
78regulation of proton transport (GO:0010155)2.96163983
79negative regulation of B cell proliferation (GO:0030889)2.95446894
80positive regulation of macrophage cytokine production (GO:0060907)2.95028813
81regulation of T-helper 1 type immune response (GO:0002825)2.94169263
82regulation of memory T cell differentiation (GO:0043380)2.92700753
83defense response to protozoan (GO:0042832)2.92600464
84detection of external biotic stimulus (GO:0098581)2.91864284
85positive regulation of tolerance induction (GO:0002645)2.91841674
86response to protozoan (GO:0001562)2.91355566
87lymphocyte homeostasis (GO:0002260)2.91147080
88negative regulation of phagocytosis (GO:0050765)2.90842405
89modulation by symbiont of host cellular process (GO:0044068)2.90731423
90respiratory burst (GO:0045730)2.90309141
91regulation of interferon-alpha production (GO:0032647)2.89824953
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89311804
93positive regulation of antigen processing and presentation (GO:0002579)2.88833777
94germinal center formation (GO:0002467)2.85412231
95negative regulation of cytokine production involved in immune response (GO:0002719)2.84673689
96leukocyte cell-cell adhesion (GO:0007159)2.84190756
97T cell costimulation (GO:0031295)2.84180876
98T cell receptor signaling pathway (GO:0050852)2.83727433
99negative regulation of T cell mediated immunity (GO:0002710)2.83372748
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83176743
101lymphocyte costimulation (GO:0031294)2.82633223
102dendritic cell differentiation (GO:0097028)2.80832055
103T cell activation involved in immune response (GO:0002286)2.80705792
104regulation of antigen processing and presentation (GO:0002577)2.79957183
105response to peptidoglycan (GO:0032494)2.79743237
106T cell differentiation involved in immune response (GO:0002292)2.78689899
107alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78689899
108alpha-beta T cell activation involved in immune response (GO:0002287)2.78689899
109regulation of B cell receptor signaling pathway (GO:0050855)2.77291821
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77083261
111negative regulation of cell killing (GO:0031342)2.77083261
112regulation of tolerance induction (GO:0002643)2.75724535
113regulation of T-helper 1 cell differentiation (GO:0045625)2.74528637
114interferon-gamma-mediated signaling pathway (GO:0060333)2.74523663
115regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73665726
116interferon-gamma secretion (GO:0072643)2.73081338
117positive regulation of defense response to virus by host (GO:0002230)2.72834152
118adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.72805637
119antigen processing and presentation via MHC class Ib (GO:0002475)2.71999699
120regulation of transforming growth factor beta production (GO:0071634)2.70739337
121response to interferon-gamma (GO:0034341)2.70465558
122positive regulation of macrophage differentiation (GO:0045651)2.70280499
123response to muramyl dipeptide (GO:0032495)2.68842588
124regulation of T-helper cell differentiation (GO:0045622)2.68676127
125negative regulation of thymocyte apoptotic process (GO:0070244)2.66852865
126inflammatory response to antigenic stimulus (GO:0002437)2.66709360
127regulation of alpha-beta T cell proliferation (GO:0046640)2.66280993
128positive regulation of T-helper 1 type immune response (GO:0002827)2.66105262
129regulation of B cell activation (GO:0050864)2.65673947
130regulation of production of molecular mediator of immune response (GO:0002700)2.65481209
131regulation of response to interferon-gamma (GO:0060330)2.65238048
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65089329
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63966699
134T cell apoptotic process (GO:0070231)2.63480745
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62431467
136positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.62308024
137negative regulation of toll-like receptor signaling pathway (GO:0034122)2.61127788
138regulation of B cell apoptotic process (GO:0002902)2.60536517
139positive regulation of B cell differentiation (GO:0045579)2.60021179
140positive regulation of interleukin-12 production (GO:0032735)2.59834021
141positive regulation of isotype switching (GO:0045830)2.59457368
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59351352
143regulation of interleukin-12 production (GO:0032655)2.58568094
144* positive regulation of cytokine biosynthetic process (GO:0042108)2.58014524
145negative regulation of myeloid cell apoptotic process (GO:0033033)2.57426023
146detection of biotic stimulus (GO:0009595)2.56814606
1473-UTR-mediated mRNA stabilization (GO:0070935)2.56743391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07239620
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68857599
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.56782789
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.45299235
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31455341
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.91924703
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.62680725
8MYC_22102868_ChIP-Seq_BL_Human3.17925270
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.13135359
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12279627
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07750236
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02407132
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.92095972
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70085191
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65556013
16MYB_26560356_Chip-Seq_TH2_Human2.54540080
17VDR_21846776_ChIP-Seq_THP-1_Human2.53082726
18RUNX_20019798_ChIP-Seq_JUKART_Human2.38354154
19MAF_26560356_Chip-Seq_TH1_Human2.35860177
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31615468
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.31311160
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26611362
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23966816
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.21105986
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13190662
26MYB_26560356_Chip-Seq_TH1_Human2.08002236
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06031937
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04654053
29UTX_26944678_Chip-Seq_JUKART_Human2.01986901
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98810854
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97168387
32VDR_24763502_ChIP-Seq_THP-1_Human1.91466185
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85271499
34TCF7_22412390_ChIP-Seq_EML_Mouse1.83736123
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82742417
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78266750
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.77227221
38SPI1_23547873_ChIP-Seq_NB4_Human1.68318164
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66144568
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64560766
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63013951
42MAF_26560356_Chip-Seq_TH2_Human1.62639848
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61003725
44KDM2B_26808549_Chip-Seq_DND41_Human1.59934160
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58449929
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55017222
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54539722
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51992898
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50987340
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50928213
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49949332
52GATA3_27048872_Chip-Seq_THYMUS_Human1.44532936
53SCL_19346495_ChIP-Seq_HPC-7_Human1.35049574
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34432143
55SPI1_23127762_ChIP-Seq_K562_Human1.30895501
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30503514
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29846975
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28112312
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28074175
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27332392
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.24484061
62GATA1_22025678_ChIP-Seq_K562_Human1.23249858
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21368175
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21108775
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18924678
66PU_27001747_Chip-Seq_BMDM_Mouse1.18215784
67* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17813064
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17316380
69GATA3_26560356_Chip-Seq_TH2_Human1.15295694
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13670827
71FOXP3_21729870_ChIP-Seq_TREG_Human1.13398237
72XRN2_22483619_ChIP-Seq_HELA_Human1.11845084
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10148157
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07742341
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06398588
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06183478
77CIITA_25753668_ChIP-Seq_RAJI_Human1.04998147
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04985351
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02358167
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.01283961
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00376412
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99865802
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99349700
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97905555
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97166979
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96987766
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96169143
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95909629
89DCP1A_22483619_ChIP-Seq_HELA_Human0.95848770
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95224525
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94849267
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93530205
93E2F1_21310950_ChIP-Seq_MCF-7_Human0.93437893
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91926196
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91710734
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89427912
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88162033
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87206794
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.86839396
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86738269
101NCOR1_26117541_ChIP-Seq_K562_Human0.84933312
102VDR_24787735_ChIP-Seq_THP-1_Human0.83833167
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83543625
104MYC_18555785_ChIP-Seq_MESCs_Mouse0.83458411
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83371769
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83269372
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83233916
108* LXR_22292898_ChIP-Seq_THP-1_Human0.78576077
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.76377035
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75382868
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74194923
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72978521
113GATA1_19941826_ChIP-Seq_K562_Human0.72698736
114KDM5A_27292631_Chip-Seq_BREAST_Human0.72604675
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71474140
116TFEB_21752829_ChIP-Seq_HELA_Human0.70433067
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70287050
118AR_21909140_ChIP-Seq_LNCAP_Human0.70114049
119RACK7_27058665_Chip-Seq_MCF-7_Human0.69933838
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69454957
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69408969
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.69018290
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.68704270
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68003789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.10230516
2MP0000685_abnormal_immune_system3.73627293
3MP0002254_reproductive_system_inflammat3.40080066
4MP0001790_abnormal_immune_system3.28797897
5MP0005387_immune_system_phenotype3.28797897
6MP0003303_peritoneal_inflammation3.15908570
7MP0004510_myositis3.11869365
8MP0001800_abnormal_humoral_immune3.03770825
9MP0003763_abnormal_thymus_physiology2.98216732
10MP0005000_abnormal_immune_tolerance2.89503365
11MP0006082_CNS_inflammation2.86265920
12* MP0005671_abnormal_response_to2.83302106
13MP0003436_decreased_susceptibility_to2.69609134
14MP0009785_altered_susceptibility_to2.59266491
15MP0005310_abnormal_salivary_gland2.54927097
16MP0002723_abnormal_immune_serum2.46885530
17MP0002452_abnormal_antigen_presenting2.45989753
18MP0005025_abnormal_response_to2.43635714
19MP0009333_abnormal_splenocyte_physiolog2.43568024
20MP0001873_stomach_inflammation2.37851328
21MP0001819_abnormal_immune_cell2.31291625
22MP0003724_increased_susceptibility_to2.30952977
23MP0002420_abnormal_adaptive_immunity2.30525235
24MP0003045_fibrosis2.26320462
25MP0003300_gastrointestinal_ulcer2.24875892
26MP0002405_respiratory_system_inflammati2.15712351
27* MP0002398_abnormal_bone_marrow2.14156964
28MP0004947_skin_inflammation2.13706214
29MP0002148_abnormal_hypersensitivity_rea2.03827267
30MP0005076_abnormal_cell_differentiation2.03402924
31MP0010155_abnormal_intestine_physiology1.98218705
32MP0002419_abnormal_innate_immunity1.96661865
33* MP0000716_abnormal_immune_system1.94751297
34MP0009278_abnormal_bone_marrow1.82632230
35* MP0000703_abnormal_thymus_morphology1.78300676
36MP0001845_abnormal_inflammatory_respons1.77536187
37* MP0002722_abnormal_immune_system1.73847907
38MP0008057_abnormal_DNA_replication1.71692253
39MP0002396_abnormal_hematopoietic_system1.71668554
40MP0002138_abnormal_hepatobiliary_system1.71290509
41MP0010352_gastrointestinal_tract_polyps1.70876703
42MP0001348_abnormal_lacrimal_gland1.62908299
43MP0003448_altered_tumor_morphology1.62238787
44* MP0002429_abnormal_blood_cell1.61470762
45MP0005645_abnormal_hypothalamus_physiol1.60024588
46MP0000689_abnormal_spleen_morphology1.56803783
47MP0001853_heart_inflammation1.56197639
48MP0003866_abnormal_defecation1.55187257
49MP0002006_tumorigenesis1.50434749
50MP0005464_abnormal_platelet_physiology1.49419514
51MP0010094_abnormal_chromosome_stability1.36078865
52MP0002166_altered_tumor_susceptibility1.35777638
53MP0005397_hematopoietic_system_phenotyp1.33406621
54MP0001545_abnormal_hematopoietic_system1.33406621
55MP0001533_abnormal_skeleton_physiology1.26270822
56MP0000858_altered_metastatic_potential1.22990888
57MP0003693_abnormal_embryo_hatching1.22608518
58MP0010307_abnormal_tumor_latency1.22052588
59MP0003111_abnormal_nucleus_morphology1.19836561
60MP0001346_abnormal_lacrimal_gland1.19834876
61MP0008260_abnormal_autophagy1.18371357
62MP0002163_abnormal_gland_morphology1.15323596
63MP0003077_abnormal_cell_cycle1.15128245
64MP0001851_eye_inflammation1.12634988
65MP0008469_abnormal_protein_level1.08804419
66MP0002277_abnormal_respiratory_mucosa1.07779721
67MP0003453_abnormal_keratinocyte_physiol1.03899160
68MP0002933_joint_inflammation1.01925311
69MP0004808_abnormal_hematopoietic_stem1.01374629
70MP0001730_embryonic_growth_arrest1.00502833
71MP0003183_abnormal_peptide_metabolism0.99690217
72MP0003172_abnormal_lysosome_physiology0.99481784
73MP0005166_decreased_susceptibility_to0.98551527
74MP0000490_abnormal_crypts_of0.97254292
75MP0005023_abnormal_wound_healing0.94359198
76MP0002019_abnormal_tumor_incidence0.92727394
77MP0004957_abnormal_blastocyst_morpholog0.89472718
78MP0003221_abnormal_cardiomyocyte_apopto0.88848504
79MP0006035_abnormal_mitochondrial_morpho0.87305096
80MP0008058_abnormal_DNA_repair0.85853386
81MP0000350_abnormal_cell_proliferation0.81265553
82MP0008775_abnormal_heart_ventricle0.76159489
83MP0002998_abnormal_bone_remodeling0.75414111
84MP0000477_abnormal_intestine_morphology0.73837266
85MP0003075_altered_response_to0.71432314
86MP0003091_abnormal_cell_migration0.69796982
87MP0000383_abnormal_hair_follicle0.69718540
88MP0003806_abnormal_nucleotide_metabolis0.69397564
89MP0005058_abnormal_lysosome_morphology0.68343335
90MP0001727_abnormal_embryo_implantation0.68216371
91MP0000343_altered_response_to0.67437881
92MP0002693_abnormal_pancreas_physiology0.64623122
93MP0002877_abnormal_melanocyte_morpholog0.64596150
94MP0002132_abnormal_respiratory_system0.64583279
95MP0003566_abnormal_cell_adhesion0.63226944
96MP0010234_abnormal_vibrissa_follicle0.62005027
97MP0003656_abnormal_erythrocyte_physiolo0.61232383
98MP0008874_decreased_physiological_sensi0.60480758
99MP0009672_abnormal_birth_weight0.60416896
100MP0000313_abnormal_cell_death0.60117141
101MP0005451_abnormal_body_composition0.60108564
102MP0009763_increased_sensitivity_to0.59706962
103MP0001663_abnormal_digestive_system0.59352706
104MP0008007_abnormal_cellular_replicative0.59094980
105MP0004381_abnormal_hair_follicle0.57646660
106MP0002168_other_aberrant_phenotype0.57473597
107MP0002080_prenatal_lethality0.57268390
108MP0009765_abnormal_xenobiotic_induced0.57044424
109MP0000627_abnormal_mammary_gland0.56798397
110MP0000371_diluted_coat_color0.56476930
111MP0009764_decreased_sensitivity_to0.55971138
112MP0000609_abnormal_liver_physiology0.55450025
113MP0000465_gastrointestinal_hemorrhage0.55419594
114MP0005621_abnormal_cell_physiology0.54971850
115MP0000604_amyloidosis0.54654826
116MP0005379_endocrine/exocrine_gland_phen0.54431638
117MP0005384_cellular_phenotype0.54223689
118MP0005380_embryogenesis_phenotype0.54197801
119MP0001672_abnormal_embryogenesis/_devel0.54197801
120MP0001881_abnormal_mammary_gland0.52985122
121MP0003984_embryonic_growth_retardation0.51843510
122MP0001697_abnormal_embryo_size0.51194843
123MP0001216_abnormal_epidermal_layer0.50575330
124MP0001501_abnormal_sleep_pattern0.49208547
125MP0001849_ear_inflammation0.48032316

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.84547488
2Recurrent fungal infections (HP:0002841)5.42833466
3Recurrent cutaneous fungal infections (HP:0011370)4.98358932
4Chronic mucocutaneous candidiasis (HP:0002728)4.98358932
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.52072670
6Myositis (HP:0100614)4.49822546
7Recurrent abscess formation (HP:0002722)4.43163320
8Retrobulbar optic neuritis (HP:0100654)4.33456140
9Optic neuritis (HP:0100653)4.33456140
10Elevated erythrocyte sedimentation rate (HP:0003565)4.28560785
11Recurrent viral infections (HP:0004429)4.26985126
12Abnormality of T cell number (HP:0011839)4.12953863
13Panhypogammaglobulinemia (HP:0003139)4.12727347
14T lymphocytopenia (HP:0005403)4.10739103
15Keratoconjunctivitis (HP:0001096)3.99200184
16Recurrent bacterial skin infections (HP:0005406)3.94749339
17Recurrent bronchitis (HP:0002837)3.85314563
18Abnormality of T cells (HP:0002843)3.84252521
19Orchitis (HP:0100796)3.82870651
20Mediastinal lymphadenopathy (HP:0100721)3.78956801
21IgM deficiency (HP:0002850)3.74602760
22Recurrent skin infections (HP:0001581)3.64629862
23Stomatitis (HP:0010280)3.61643316
24Nasal polyposis (HP:0100582)3.60309464
25B lymphocytopenia (HP:0010976)3.58257801
26Abnormality of B cell number (HP:0010975)3.58257801
27Pustule (HP:0200039)3.54308681
28Vasculitis (HP:0002633)3.49701192
29Chronic otitis media (HP:0000389)3.49692959
30Abnormality of T cell physiology (HP:0011840)3.43969487
31Abnormality of macrophages (HP:0004311)3.41245438
32Chronic obstructive pulmonary disease (HP:0006510)3.41140993
33Obstructive lung disease (HP:0006536)3.41140993
34Increased IgE level (HP:0003212)3.31734640
35Meningitis (HP:0001287)3.24333866
36Recurrent gram-negative bacterial infections (HP:0005420)3.21130726
37IgA deficiency (HP:0002720)3.19907167
38Combined immunodeficiency (HP:0005387)3.06052183
39Interstitial pulmonary disease (HP:0006530)2.95870272
40Increased IgM level (HP:0003496)2.92776979
41Inflammation of the large intestine (HP:0002037)2.90321271
42Hypertensive crisis (HP:0100735)2.88667940
43Gastrointestinal inflammation (HP:0004386)2.87006394
44Severe combined immunodeficiency (HP:0004430)2.86992641
45Pulmonary infiltrates (HP:0002113)2.82474735
46Abnormality of the nasal mucosa (HP:0000433)2.82215874
47Eosinophilia (HP:0001880)2.81139869
48Viral hepatitis (HP:0006562)2.80494801
49Keratoconjunctivitis sicca (HP:0001097)2.78212888
50IgG deficiency (HP:0004315)2.75361877
51Autoimmune thrombocytopenia (HP:0001973)2.73547118
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.71565209
53Lymphopenia (HP:0001888)2.70007533
54Leukocytosis (HP:0001974)2.68204351
55Hypergammaglobulinemia (HP:0010702)2.65704976
56Abnormality of the fingertips (HP:0001211)2.61714211
57Arterial thrombosis (HP:0004420)2.60804362
58Colitis (HP:0002583)2.57672823
59Gingivitis (HP:0000230)2.57017330
60Encephalitis (HP:0002383)2.56054027
61Gastrointestinal stroma tumor (HP:0100723)2.52760023
62Periodontitis (HP:0000704)2.51159416
63Joint swelling (HP:0001386)2.50145661
64Emphysema (HP:0002097)2.47335598
65Hemoptysis (HP:0002105)2.45389662
66Abnormality of eosinophils (HP:0001879)2.44976415
67Cellulitis (HP:0100658)2.43839520
68Premature loss of primary teeth (HP:0006323)2.43809224
69Granulocytopenia (HP:0001913)2.40757281
70Verrucae (HP:0200043)2.40539317
71Papilloma (HP:0012740)2.40539317
72Xerostomia (HP:0000217)2.39261472
73Gastrointestinal infarctions (HP:0005244)2.31003857
74Lymphoma (HP:0002665)2.29824046
75Squamous cell carcinoma (HP:0002860)2.29327171
76Chronic diarrhea (HP:0002028)2.27706649
77Abnormal gallbladder physiology (HP:0012438)2.22546917
78Cholecystitis (HP:0001082)2.22546917
79Skin rash (HP:0000988)2.18687738
80Hepatitis (HP:0012115)2.18629926
81Autoimmune hemolytic anemia (HP:0001890)2.17809141
82Leukopenia (HP:0001882)2.16187153
83Recurrent sinusitis (HP:0011108)2.14860922
84Sepsis (HP:0100806)2.14121054
85Agammaglobulinemia (HP:0004432)2.10557938
86Urticaria (HP:0001025)2.09528388
87Keratitis (HP:0000491)2.08985030
88Anorexia (HP:0002039)2.08839292
89Fatigue (HP:0012378)2.08652775
90Bronchitis (HP:0012387)2.07056655
91Progressive external ophthalmoplegia (HP:0000590)2.05532546
92Thyroiditis (HP:0100646)2.05268273
93Recurrent otitis media (HP:0000403)2.02859960
94Petechiae (HP:0000967)2.02495221
95Thrombocytosis (HP:0001894)2.02034058
96Abnormality of the pleura (HP:0002103)2.01920399
97Aplasia/Hypoplasia of the thymus (HP:0010515)2.01587853
98Skin ulcer (HP:0200042)2.00783411
99Gingival bleeding (HP:0000225)1.99835188
100Cheilitis (HP:0100825)1.98133114
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96689271
102Amaurosis fugax (HP:0100576)1.96436060
103Gangrene (HP:0100758)1.95518079
104Spontaneous hematomas (HP:0007420)1.92775284
105Recurrent lower respiratory tract infections (HP:0002783)1.91800305
106Restrictive lung disease (HP:0002091)1.91602678
107Chest pain (HP:0100749)1.91560239
108Arthralgia (HP:0002829)1.90802633
109Poikiloderma (HP:0001029)1.89873954
110Basal cell carcinoma (HP:0002671)1.86455503
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.85009362
112Abnormality of the peritoneum (HP:0002585)1.84549333
113Abnormality of the prostate (HP:0008775)1.84319642
114Impaired proprioception (HP:0010831)1.83791624
115Recurrent pneumonia (HP:0006532)1.83756302
116Teleangiectasia of the skin (HP:0100585)1.81973000
117Acute hepatic failure (HP:0006554)1.81746189
118Chronic sinusitis (HP:0011109)1.77394256
119Osteomyelitis (HP:0002754)1.76733195
120Polyneuropathy (HP:0001271)1.76678944
121Agnosia (HP:0010524)1.76407360
122Pulmonary embolism (HP:0002204)1.73833505
123Asplenia (HP:0001746)1.73423233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.78762247
2PRPF4B3.80260697
3SMG13.76260473
4MAP3K143.54336595
5TXK3.20669734
6JAK32.92859651
7BLK2.61269741
8TYK22.58705683
9STK102.48521669
10EEF2K2.40665000
11TBK12.29504567
12JAK12.26547066
13RIPK42.24987226
14ZAP702.04988949
15CDK121.94452672
16GRK61.91167806
17IKBKB1.85089942
18IKBKE1.84574038
19FGFR41.82600987
20MAP3K131.75828145
21MAP3K101.70848837
22SYK1.69874346
23NEK21.67525569
24EPHB11.63537047
25ALK1.59605924
26ITK1.57517408
27IRAK41.55678248
28LRRK21.48608633
29TRIB31.48282828
30SIK21.41164134
31CSK1.41015380
32IRAK31.40337893
33MATK1.38210853
34CHUK1.37853758
35HCK1.34903001
36TAF11.34546673
37LCK1.34305306
38BTK1.33249692
39CLK11.32829827
40NLK1.30258127
41PIM11.29731670
42NEK91.28226507
43MST41.22549138
44ERN11.20775325
45CDC71.20063718
46EPHA31.19073454
47JAK21.18770431
48CDK41.17510818
49FGFR31.16795192
50PKN21.15870964
51CDK191.13159426
52EIF2AK31.08442553
53FES1.08039261
54RPS6KA41.07177596
55TAOK21.07004752
56VRK11.04797923
57CDK61.04138749
58CSF1R1.03789643
59CDC42BPA1.03375469
60KIT1.02560934
61VRK21.01581113
62FGR0.93479218
63BMPR20.93308806
64BMX0.90779302
65PTK60.87403764
66TEC0.86864996
67TAOK30.85510518
68MARK30.84656100
69MELK0.82412876
70MAP2K30.80037878
71TESK20.79660134
72LYN0.76156145
73NME20.75471763
74PRKCQ0.74081332
75RPS6KB20.72783994
76MAP3K80.69573398
77MAP3K70.68780457
78CDK90.67060161
79MAP3K90.63642013
80TSSK60.63380456
81RPS6KA50.62765071
82TNK20.61177915
83HIPK20.60758185
84NME10.57807502
85DAPK30.57805993
86ARAF0.57691179
87STK40.57023578
88TTK0.54166626
89PIM20.53180560
90TAOK10.51897402
91SRPK10.49963953
92PDK10.49926886
93TLK10.49722993
94PRKCH0.48088147
95BRD40.47520345
96CHEK20.46773303
97MAP3K10.46625529
98CHEK10.46103016
99EGFR0.46087677
100BUB10.45842017
101BRAF0.45121922
102PDGFRB0.44933659
103IRAK10.44841706
104ATR0.41987531
105AURKA0.40337258
106YES10.40158367
107MAPK120.39338408
108SIK30.39336337
109KSR20.39310879
110TGFBR10.38591107
111TNIK0.38285632
112MAPKAPK20.36190389
113RAF10.34842158
114TESK10.34232220
115ZAK0.33896174
116NEK10.32891496
117ABL10.32802652
118SCYL20.31960326
119ICK0.31811824
120PLK10.31262500
121CDK70.30663626
122KDR0.30197669
123PASK0.29818861
124RPS6KA10.29717854
125MTOR0.29409769
126STK240.28308433
127PRKCD0.27820688
128MAPK30.27280898
129ATM0.27068016
130CDK20.26622412
131MAPK110.26089219
132INSR0.26063735

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.97736874
2Allograft rejection_Homo sapiens_hsa053304.34814658
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.55802211
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.27037217
5Primary immunodeficiency_Homo sapiens_hsa053403.26261992
6Autoimmune thyroid disease_Homo sapiens_hsa053203.06722606
7Systemic lupus erythematosus_Homo sapiens_hsa053222.39903676
8Leishmaniasis_Homo sapiens_hsa051402.39402505
9Measles_Homo sapiens_hsa051622.23424994
10T cell receptor signaling pathway_Homo sapiens_hsa046602.23046495
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.21031750
12Hematopoietic cell lineage_Homo sapiens_hsa046401.98920575
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.98416244
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95044371
15Osteoclast differentiation_Homo sapiens_hsa043801.78053445
16Antigen processing and presentation_Homo sapiens_hsa046121.78042545
17Graft-versus-host disease_Homo sapiens_hsa053321.68888220
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59342912
19Legionellosis_Homo sapiens_hsa051341.50482026
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45440981
21B cell receptor signaling pathway_Homo sapiens_hsa046621.43441376
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43275480
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37439443
24* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36251621
25Herpes simplex infection_Homo sapiens_hsa051681.33524350
26Toxoplasmosis_Homo sapiens_hsa051451.32839667
27TNF signaling pathway_Homo sapiens_hsa046681.29865122
28Influenza A_Homo sapiens_hsa051641.28749281
29Staphylococcus aureus infection_Homo sapiens_hsa051501.27496469
30Type I diabetes mellitus_Homo sapiens_hsa049401.25824008
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24381364
32Chemokine signaling pathway_Homo sapiens_hsa040621.20616241
33Tuberculosis_Homo sapiens_hsa051521.20179010
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19976483
35Apoptosis_Homo sapiens_hsa042101.14086950
36DNA replication_Homo sapiens_hsa030301.09280216
37Malaria_Homo sapiens_hsa051441.07241975
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03679779
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02993917
40Pertussis_Homo sapiens_hsa051331.02990529
41African trypanosomiasis_Homo sapiens_hsa051431.02886970
42Hepatitis B_Homo sapiens_hsa051611.02195922
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02006293
44Acute myeloid leukemia_Homo sapiens_hsa052210.98720627
45Chronic myeloid leukemia_Homo sapiens_hsa052200.95406028
46Shigellosis_Homo sapiens_hsa051310.94824874
47Epstein-Barr virus infection_Homo sapiens_hsa051690.89810244
48Mismatch repair_Homo sapiens_hsa034300.88861811
49Alcoholism_Homo sapiens_hsa050340.88426909
50Viral myocarditis_Homo sapiens_hsa054160.88023551
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87444338
52Non-homologous end-joining_Homo sapiens_hsa034500.84416626
53HTLV-I infection_Homo sapiens_hsa051660.79727023
54Viral carcinogenesis_Homo sapiens_hsa052030.77589581
55p53 signaling pathway_Homo sapiens_hsa041150.75765728
56Rheumatoid arthritis_Homo sapiens_hsa053230.75430652
57Base excision repair_Homo sapiens_hsa034100.74131550
58Pancreatic cancer_Homo sapiens_hsa052120.72646276
59Prolactin signaling pathway_Homo sapiens_hsa049170.69768974
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.69305053
61Salmonella infection_Homo sapiens_hsa051320.67226574
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67161624
63Cell cycle_Homo sapiens_hsa041100.65718624
64Small cell lung cancer_Homo sapiens_hsa052220.65194493
65Dorso-ventral axis formation_Homo sapiens_hsa043200.63032228
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62245138
67VEGF signaling pathway_Homo sapiens_hsa043700.59080381
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.57356547
69MicroRNAs in cancer_Homo sapiens_hsa052060.57051096
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55898226
71One carbon pool by folate_Homo sapiens_hsa006700.55220649
72Hepatitis C_Homo sapiens_hsa051600.53501810
73Notch signaling pathway_Homo sapiens_hsa043300.53364230
74Colorectal cancer_Homo sapiens_hsa052100.52530295
75HIF-1 signaling pathway_Homo sapiens_hsa040660.52430283
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.50847596
77Biosynthesis of amino acids_Homo sapiens_hsa012300.50414669
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46440164
79Pentose phosphate pathway_Homo sapiens_hsa000300.46025684
80mTOR signaling pathway_Homo sapiens_hsa041500.45673874
81Ribosome_Homo sapiens_hsa030100.44285304
82Homologous recombination_Homo sapiens_hsa034400.44275685
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42322105
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41487512
85Fructose and mannose metabolism_Homo sapiens_hsa000510.41281729
86Type II diabetes mellitus_Homo sapiens_hsa049300.40751520
87RNA transport_Homo sapiens_hsa030130.39586543
88Non-small cell lung cancer_Homo sapiens_hsa052230.38173925
89Prostate cancer_Homo sapiens_hsa052150.37895064
90Spliceosome_Homo sapiens_hsa030400.37122777
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.36930286
92Nucleotide excision repair_Homo sapiens_hsa034200.36753446
93Renal cell carcinoma_Homo sapiens_hsa052110.36379377
94FoxO signaling pathway_Homo sapiens_hsa040680.35943940
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35863366
96Amoebiasis_Homo sapiens_hsa051460.35164654
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32390962
98Platelet activation_Homo sapiens_hsa046110.31639787
99MAPK signaling pathway_Homo sapiens_hsa040100.30656053
100Bladder cancer_Homo sapiens_hsa052190.29990564
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29941605
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.29484248
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27246196
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26407973
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25493740
106Carbon metabolism_Homo sapiens_hsa012000.25020431
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23071854
108Endometrial cancer_Homo sapiens_hsa052130.22899522
109mRNA surveillance pathway_Homo sapiens_hsa030150.22460006
110Thyroid cancer_Homo sapiens_hsa052160.22317762
111Pyrimidine metabolism_Homo sapiens_hsa002400.21660570
112Lysosome_Homo sapiens_hsa041420.21437761
113Phagosome_Homo sapiens_hsa041450.20270972
114Proteasome_Homo sapiens_hsa030500.20196551
115Endocytosis_Homo sapiens_hsa041440.19859111
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.19482111
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18620980
118RNA degradation_Homo sapiens_hsa030180.18000633
119Other glycan degradation_Homo sapiens_hsa005110.17500115

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »