TNFRSF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.97951212
2regulation of dendritic cell antigen processing and presentation (GO:0002604)5.94213132
3DNA deamination (GO:0045006)5.87336473
4regulation of lymphocyte chemotaxis (GO:1901623)5.76739678
5regulation of T-helper 1 cell differentiation (GO:0045625)5.63722840
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.48612039
7negative thymic T cell selection (GO:0045060)5.44576607
8negative T cell selection (GO:0043383)5.29809403
9negative regulation of T cell mediated immunity (GO:0002710)5.23769134
10positive regulation of T-helper 1 type immune response (GO:0002827)5.15218938
11regulation of chronic inflammatory response (GO:0002676)5.15019807
12interferon-gamma production (GO:0032609)4.83321193
13antigen processing and presentation of endogenous antigen (GO:0019883)4.79923799
14cytidine catabolic process (GO:0006216)4.78825998
15cytidine deamination (GO:0009972)4.78825998
16cytidine metabolic process (GO:0046087)4.78825998
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.75343211
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69554257
19positive regulation of antigen processing and presentation (GO:0002579)4.64029273
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59084822
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59084822
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.56867052
23positive regulation of immune response to tumor cell (GO:0002839)4.54342227
24regulation of immune response to tumor cell (GO:0002837)4.54342227
25regulation of response to tumor cell (GO:0002834)4.54342227
26positive regulation of response to tumor cell (GO:0002836)4.54342227
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.51157294
28myeloid dendritic cell differentiation (GO:0043011)4.51016491
29regulation of T-helper 1 type immune response (GO:0002825)4.48592543
30negative regulation of interleukin-2 production (GO:0032703)4.43649529
31regulation of RIG-I signaling pathway (GO:0039535)4.43246026
32cellular response to interleukin-15 (GO:0071350)4.43146176
33positive regulation of T-helper cell differentiation (GO:0045624)4.42025099
34pyrimidine ribonucleoside catabolic process (GO:0046133)4.35585286
35regulation of T cell tolerance induction (GO:0002664)4.30430621
36positive regulation of gamma-delta T cell activation (GO:0046645)4.28702215
37response to interleukin-15 (GO:0070672)4.28657063
38positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.27252080
39thymic T cell selection (GO:0045061)4.21514445
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.19620214
41positive regulation of alpha-beta T cell proliferation (GO:0046641)4.18866669
42regulation of isotype switching to IgG isotypes (GO:0048302)4.18233623
43positive thymic T cell selection (GO:0045059)4.16987333
44NIK/NF-kappaB signaling (GO:0038061)4.16666010
45positive regulation of lymphocyte migration (GO:2000403)4.13818201
46positive regulation of neutrophil chemotaxis (GO:0090023)4.13594031
47positive regulation of neutrophil migration (GO:1902624)4.13594031
48regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.12960644
49regulation of alpha-beta T cell proliferation (GO:0046640)4.10141985
50positive regulation of granulocyte chemotaxis (GO:0071624)4.07614098
51regulation of T-helper cell differentiation (GO:0045622)4.07541486
52positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.06410691
53positive regulation of interleukin-10 production (GO:0032733)4.06069442
54myeloid dendritic cell activation (GO:0001773)4.00699909
55alpha-beta T cell differentiation involved in immune response (GO:0002293)3.99880989
56alpha-beta T cell activation involved in immune response (GO:0002287)3.99880989
57T cell differentiation involved in immune response (GO:0002292)3.99880989
58L-fucose catabolic process (GO:0042355)3.96809424
59fucose catabolic process (GO:0019317)3.96809424
60L-fucose metabolic process (GO:0042354)3.96809424
61negative regulation of interleukin-12 production (GO:0032695)3.96547046
62regulation of immunoglobulin secretion (GO:0051023)3.96095806
63regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.91384370
64regulation of antigen processing and presentation (GO:0002577)3.87894551
65tolerance induction (GO:0002507)3.86207435
66regulation of memory T cell differentiation (GO:0043380)3.84685089
67lymphocyte chemotaxis (GO:0048247)3.84188646
68T cell selection (GO:0045058)3.82655814
69dendritic cell differentiation (GO:0097028)3.79608779
70regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.78992743
71tyrosine phosphorylation of STAT protein (GO:0007260)3.70368240
72heterotypic cell-cell adhesion (GO:0034113)3.69989975
73defense response to protozoan (GO:0042832)3.69113157
74positive regulation of lymphocyte mediated immunity (GO:0002708)3.68217262
75positive regulation of interleukin-12 production (GO:0032735)3.67769075
76T cell costimulation (GO:0031295)3.67266196
77leukocyte tethering or rolling (GO:0050901)3.66252677
78necroptotic process (GO:0070266)3.65268582
79positive regulation of humoral immune response (GO:0002922)3.61985110
80lymphocyte costimulation (GO:0031294)3.61860605
81T-helper cell differentiation (GO:0042093)3.57812312
82CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.57812312
83negative regulation by host of viral transcription (GO:0043922)3.56022484
84negative regulation of alpha-beta T cell activation (GO:0046636)3.55483011
85positive regulation of interleukin-2 production (GO:0032743)3.53430491
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.46848800
87positive regulation of T cell chemotaxis (GO:0010820)3.42315415
88regulation of T cell chemotaxis (GO:0010819)3.42315415
89positive T cell selection (GO:0043368)3.41122510
90positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37343164
91regulation of vitamin D biosynthetic process (GO:0060556)3.36344702
92negative regulation of cytokine production involved in immune response (GO:0002719)3.36201987
93positive regulation of isotype switching (GO:0045830)3.34688000
94positive regulation of T cell migration (GO:2000406)3.34207372
95regulation of tolerance induction (GO:0002643)3.33864997
96positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.32785007
97regulation of interleukin-2 biosynthetic process (GO:0045076)3.32297180
98T cell migration (GO:0072678)3.31620950
99positive regulation of T cell cytokine production (GO:0002726)3.31140227
100positive regulation of B cell mediated immunity (GO:0002714)3.31106551
101positive regulation of immunoglobulin mediated immune response (GO:0002891)3.31106551
102regulation of hypersensitivity (GO:0002883)3.30553450
103regulation of podosome assembly (GO:0071801)3.28942754
104regulation of interleukin-12 production (GO:0032655)3.28064185
105regulation of T cell cytokine production (GO:0002724)3.27874185
106dendritic cell chemotaxis (GO:0002407)3.27634510
107response to protozoan (GO:0001562)3.27022774
108positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.26707255
109positive regulation of natural killer cell mediated immunity (GO:0002717)3.26707255
110regulation of immunoglobulin mediated immune response (GO:0002889)3.26243288
111regulation of gamma-delta T cell differentiation (GO:0045586)3.24831174
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24048223
113positive regulation of immunoglobulin production (GO:0002639)3.23544811
114response to prostaglandin E (GO:0034695)3.22600745
115regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21007286
116regulation of natural killer cell mediated immunity (GO:0002715)3.20871263
117regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.20871263
118regulation of regulatory T cell differentiation (GO:0045589)3.20792873
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.20428671
120negative regulation of adaptive immune response (GO:0002820)3.17493611
121positive regulation of leukocyte mediated immunity (GO:0002705)3.17237796
122positive regulation of macrophage differentiation (GO:0045651)3.16900369
123positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.16861916
124rRNA methylation (GO:0031167)3.16548692
125positive regulation of defense response to virus by host (GO:0002230)3.16282372
126rRNA modification (GO:0000154)3.15579096
127positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.14846212
128regulation of B cell mediated immunity (GO:0002712)3.14328111
129regulation of activation of Janus kinase activity (GO:0010533)3.13570593
130regulation of T cell mediated cytotoxicity (GO:0001914)3.12448871
131regulation of T cell receptor signaling pathway (GO:0050856)3.12337446
132positive regulation of alpha-beta T cell differentiation (GO:0046638)3.11214663
133cytokine secretion (GO:0050663)3.09352298
134positive regulation of activated T cell proliferation (GO:0042104)3.08932680
135positive regulation of Cdc42 GTPase activity (GO:0043089)3.08054775
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.08004468
137regulation of alpha-beta T cell differentiation (GO:0046637)3.07405730
138positive regulation of DNA recombination (GO:0045911)3.06743654
139positive regulation of cell killing (GO:0031343)3.06743020
140regulation of interleukin-1 beta secretion (GO:0050706)3.06049213
141regulation of lymphocyte mediated immunity (GO:0002706)3.04813099
142regulation of endothelial cell differentiation (GO:0045601)3.02817328
143regulation of interleukin-10 production (GO:0032653)3.02631580
144positive regulation of alpha-beta T cell activation (GO:0046635)3.01723116
145regulation of alpha-beta T cell activation (GO:0046634)3.00807344
146alpha-beta T cell differentiation (GO:0046632)2.99761343
147T cell mediated immunity (GO:0002456)2.99598797
148positive regulation of interleukin-17 production (GO:0032740)2.99423201
149regulation of cell killing (GO:0031341)2.99155317
150regulation of lymphocyte migration (GO:2000401)2.98500914
151regulation of B cell receptor signaling pathway (GO:0050855)2.97971000
152CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.97498265
153cellular response to nicotine (GO:0071316)2.97437558
154regulation of immunoglobulin production (GO:0002637)2.95527967
155leukocyte cell-cell adhesion (GO:0007159)2.95394540
156positive regulation of T cell mediated immunity (GO:0002711)2.92068158
157negative regulation of production of molecular mediator of immune response (GO:0002701)2.91581836
158positive regulation of calcium-mediated signaling (GO:0050850)2.87964113
159positive regulation of type 2 immune response (GO:0002830)2.86124904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.61876513
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.19020381
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.87681732
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.50021530
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.02862186
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.87959219
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.84003503
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71918774
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.54258541
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.43821113
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.19636289
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.17375302
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98964162
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.89653972
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.83194327
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.82116767
17RUNX_20019798_ChIP-Seq_JUKART_Human2.78194498
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61165247
19MYB_26560356_Chip-Seq_TH2_Human2.60081354
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45538605
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45354900
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.40590578
23ZNF274_21170338_ChIP-Seq_K562_Hela2.33217051
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29541210
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29506417
26PCGF2_27294783_Chip-Seq_NPCs_Mouse2.28127363
27VDR_22108803_ChIP-Seq_LS180_Human2.23949287
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22168034
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19545850
30* MAF_26560356_Chip-Seq_TH1_Human2.15118314
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15050523
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.14580152
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.09170981
34MYB_26560356_Chip-Seq_TH1_Human2.09157346
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02335130
36GATA2_21666600_ChIP-Seq_HMVEC_Human2.00284844
37VDR_23849224_ChIP-Seq_CD4+_Human1.90554428
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89104049
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85897944
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83186253
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77177964
42VDR_24787735_ChIP-Seq_THP-1_Human1.76698262
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.75124717
44GATA3_27048872_Chip-Seq_THYMUS_Human1.73219644
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64111477
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61895135
47UTX_26944678_Chip-Seq_JUKART_Human1.60463475
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.59027260
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.58403422
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57535961
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56601333
52SCL_19346495_ChIP-Seq_HPC-7_Human1.50252462
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49036242
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47305779
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44006917
56VDR_24763502_ChIP-Seq_THP-1_Human1.36949624
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35430449
58IRF1_19129219_ChIP-ChIP_H3396_Human1.35348914
59MYC_22102868_ChIP-Seq_BL_Human1.35162888
60TP53_22573176_ChIP-Seq_HFKS_Human1.32614531
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.32007400
62SPI1_23547873_ChIP-Seq_NB4_Human1.30981436
63FOXP3_21729870_ChIP-Seq_TREG_Human1.30196067
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.27884016
65PU_27001747_Chip-Seq_BMDM_Mouse1.27402037
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26543586
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.24352486
68GATA3_26560356_Chip-Seq_TH2_Human1.22838806
69* MAF_26560356_Chip-Seq_TH2_Human1.22711478
70SPI1_23127762_ChIP-Seq_K562_Human1.20271525
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20063201
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17949216
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.17841901
74ER_23166858_ChIP-Seq_MCF-7_Human1.16965033
75TCF7_22412390_ChIP-Seq_EML_Mouse1.16598864
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13238506
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10493474
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10273357
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08667971
80MYC_18940864_ChIP-ChIP_HL60_Human1.08665388
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06248515
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06217065
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05707259
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05021873
85VDR_21846776_ChIP-Seq_THP-1_Human1.04022049
86HOXB7_26014856_ChIP-Seq_BT474_Human1.03648215
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.03161496
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02770192
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02718603
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02088009
91P300_18555785_Chip-Seq_ESCs_Mouse1.01827896
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01233139
93* FOXA1_25329375_ChIP-Seq_VCAP_Human1.01131796
94* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01131796
95GATA3_26560356_Chip-Seq_TH1_Human1.00759113
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.00458335
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00164070
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99946942
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.99942458
100ELK1_19687146_ChIP-ChIP_HELA_Human0.99585365
101BCAT_22108803_ChIP-Seq_LS180_Human0.97849979
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97385038
103* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95864634
104EWS_26573619_Chip-Seq_HEK293_Human0.95849466
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95037723
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94620627
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94215274
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93779300
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93288597
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92989624
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92742173
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92652991
113OCT4_18555785_Chip-Seq_ESCs_Mouse0.92432305
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91764521
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.91226145
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.90996344
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90760592
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90293134
119* GATA3_21878914_ChIP-Seq_MCF-7_Human0.90233204
120* FOXH1_21741376_ChIP-Seq_EPCs_Human0.90074376
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89957518
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89748734
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88815133
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88815133
125P53_22387025_ChIP-Seq_ESCs_Mouse0.88571993
126TAF2_19829295_ChIP-Seq_ESCs_Human0.88561216
127SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87678831
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86688729
129SOX2_20726797_ChIP-Seq_SW620_Human0.86042551
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85686816
131KDM2B_26808549_Chip-Seq_DND41_Human0.85230383
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84744488
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84289123
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84176599
135* NMYC_18555785_Chip-Seq_ESCs_Mouse0.83171263
136* RBPJ_21746931_ChIP-Seq_IB4_Human0.83040595
137SOX2_19829295_ChIP-Seq_ESCs_Human0.82741915
138NANOG_19829295_ChIP-Seq_ESCs_Human0.82741915
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82718101
140MYC_19829295_ChIP-Seq_ESCs_Human0.82661796
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82341829
142GATA1_19941826_ChIP-Seq_K562_Human0.82136723
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82080948
144* GATA6_21074721_ChIP-Seq_CACO-2_Human0.81860038
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81669813
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80847495
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80807172
148* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80775807
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.80659799
150CTCF_18555785_Chip-Seq_ESCs_Mouse0.80525519
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80044680
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.77121623
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74902298
154EGR1_19032775_ChIP-ChIP_M12_Human0.74464407
155CJUN_26792858_Chip-Seq_BT549_Human0.73914854
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72756798
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72412961
158FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72386418
159SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72367345
160SMRT_27268052_Chip-Seq_Bcells_Human0.70765003
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70425072
162* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70423275
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69634202
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69590849
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69314020
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69231348
167TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69003930
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68913219
169GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68662669
170CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67126116
171ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66349460
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65803436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.56388696
2MP0000685_abnormal_immune_system4.41612652
3MP0001835_abnormal_antigen_presentation3.92728486
4MP0003300_gastrointestinal_ulcer3.56033281
5MP0002138_abnormal_hepatobiliary_system3.12202292
6MP0004510_myositis2.95401965
7MP0001790_abnormal_immune_system2.93135955
8MP0005387_immune_system_phenotype2.93135955
9MP0003763_abnormal_thymus_physiology2.92292145
10MP0003724_increased_susceptibility_to2.89206281
11MP0006082_CNS_inflammation2.85464494
12MP0009785_altered_susceptibility_to2.79158747
13MP0005000_abnormal_immune_tolerance2.72731067
14MP0006054_spinal_hemorrhage2.64917506
15MP0000569_abnormal_digit_pigmentation2.62795286
16MP0002148_abnormal_hypersensitivity_rea2.56930447
17MP0002254_reproductive_system_inflammat2.56713881
18* MP0001800_abnormal_humoral_immune2.56352327
19MP0003436_decreased_susceptibility_to2.47499885
20* MP0002723_abnormal_immune_serum2.30813085
21MP0001348_abnormal_lacrimal_gland2.25055500
22MP0005025_abnormal_response_to2.24058800
23MP0002405_respiratory_system_inflammati2.22320276
24MP0002877_abnormal_melanocyte_morpholog2.19163790
25MP0003303_peritoneal_inflammation2.18968154
26MP0001873_stomach_inflammation2.18685589
27* MP0001819_abnormal_immune_cell2.17601072
28* MP0002420_abnormal_adaptive_immunity2.16927445
29* MP0002452_abnormal_antigen_presenting2.14251504
30MP0002166_altered_tumor_susceptibility2.12574973
31MP0005310_abnormal_salivary_gland2.09566247
32MP0001879_abnormal_lymphatic_vessel2.08590573
33* MP0009333_abnormal_splenocyte_physiolog1.93897594
34MP0002163_abnormal_gland_morphology1.90360192
35MP0002006_tumorigenesis1.88850956
36* MP0002398_abnormal_bone_marrow1.87014030
37MP0001853_heart_inflammation1.83719436
38MP0002419_abnormal_innate_immunity1.81008954
39MP0001501_abnormal_sleep_pattern1.76656563
40* MP0000716_abnormal_immune_system1.72965471
41MP0003448_altered_tumor_morphology1.72434268
42MP0010155_abnormal_intestine_physiology1.71052421
43MP0008057_abnormal_DNA_replication1.68934807
44MP0004381_abnormal_hair_follicle1.66765132
45MP0003045_fibrosis1.64808969
46MP0003866_abnormal_defecation1.64153047
47MP0004947_skin_inflammation1.60671980
48MP0003195_calcinosis1.57723168
49MP0001845_abnormal_inflammatory_respons1.53233030
50MP0000372_irregular_coat_pigmentation1.50051707
51MP0003646_muscle_fatigue1.48518504
52MP0001851_eye_inflammation1.46468313
53MP0003566_abnormal_cell_adhesion1.46012570
54MP0005464_abnormal_platelet_physiology1.45791684
55MP0002722_abnormal_immune_system1.43321524
56* MP0002429_abnormal_blood_cell1.40285932
57MP0000703_abnormal_thymus_morphology1.39731003
58MP0008872_abnormal_physiological_respon1.38623254
59MP0010368_abnormal_lymphatic_system1.35032085
60MP0001346_abnormal_lacrimal_gland1.34015178
61MP0008875_abnormal_xenobiotic_pharmacok1.33385524
62MP0000465_gastrointestinal_hemorrhage1.33350819
63MP0001533_abnormal_skeleton_physiology1.33074913
64MP0000689_abnormal_spleen_morphology1.32009924
65MP0000858_altered_metastatic_potential1.30709823
66MP0004742_abnormal_vestibular_system1.23750819
67MP0005167_abnormal_blood-brain_barrier1.22440866
68MP0004142_abnormal_muscle_tone1.19473145
69MP0003091_abnormal_cell_migration1.14207176
70MP0002396_abnormal_hematopoietic_system1.12154843
71MP0001881_abnormal_mammary_gland1.10188818
72MP0008469_abnormal_protein_level1.10026449
73MP0004043_abnormal_pH_regulation1.08521095
74MP0005075_abnormal_melanosome_morpholog1.05847755
75MP0002102_abnormal_ear_morphology1.03261112
76MP0002933_joint_inflammation1.01935106
77MP0002653_abnormal_ependyma_morphology1.00327357
78MP0009764_decreased_sensitivity_to0.97988412
79MP0002998_abnormal_bone_remodeling0.95764576
80MP0000249_abnormal_blood_vessel0.94056079
81MP0001919_abnormal_reproductive_system0.90377008
82MP0005551_abnormal_eye_electrophysiolog0.88753121
83MP0002876_abnormal_thyroid_physiology0.88458955
84MP0000767_abnormal_smooth_muscle0.88223260
85MP0001502_abnormal_circadian_rhythm0.87293396
86MP0005076_abnormal_cell_differentiation0.86430483
87MP0005379_endocrine/exocrine_gland_phen0.83076518
88MP0000013_abnormal_adipose_tissue0.82075590
89MP0005623_abnormal_meninges_morphology0.81333195
90MP0000343_altered_response_to0.80190190
91MP0000371_diluted_coat_color0.79271141
92MP0005645_abnormal_hypothalamus_physiol0.76996762
93MP0001986_abnormal_taste_sensitivity0.76511625
94MP0001958_emphysema0.76170708
95MP0005390_skeleton_phenotype0.74817726
96MP0002837_dystrophic_cardiac_calcinosis0.74794772
97MP0005647_abnormal_sex_gland0.73979341
98MP0003828_pulmonary_edema0.73583923
99MP0003453_abnormal_keratinocyte_physiol0.72958839
100MP0009745_abnormal_behavioral_response0.72245991
101MP0003806_abnormal_nucleotide_metabolis0.70617962
102MP0002693_abnormal_pancreas_physiology0.70615894
103MP0003183_abnormal_peptide_metabolism0.70352381
104MP0001968_abnormal_touch/_nociception0.69915719
105MP0000627_abnormal_mammary_gland0.68335500
106MP0005381_digestive/alimentary_phenotyp0.68181782
107MP0002277_abnormal_respiratory_mucosa0.65853240
108MP0000490_abnormal_crypts_of0.65627554
109MP0006072_abnormal_retinal_apoptosis0.62075034
110MP0003172_abnormal_lysosome_physiology0.62014063
111MP0003186_abnormal_redox_activity0.61227743
112MP0003786_premature_aging0.61135584
113MP0005410_abnormal_fertilization0.60746894
114MP0004782_abnormal_surfactant_physiolog0.60731207
115MP0001663_abnormal_digestive_system0.60411009
116MP0009046_muscle_twitch0.59998907
117MP0009763_increased_sensitivity_to0.59990345
118MP0001905_abnormal_dopamine_level0.59457716
119MP0002928_abnormal_bile_duct0.59069368
120MP0001915_intracranial_hemorrhage0.58832080
121MP0002009_preneoplasia0.58519127
122MP0005164_abnormal_response_to0.58202990
123MP0005023_abnormal_wound_healing0.58186892
124MP0005397_hematopoietic_system_phenotyp0.57709805
125MP0001545_abnormal_hematopoietic_system0.57709805
126MP0000613_abnormal_salivary_gland0.57045286
127MP0005377_hearing/vestibular/ear_phenot0.56279529
128MP0003878_abnormal_ear_physiology0.56279529
129MP0004808_abnormal_hematopoietic_stem0.56232614
130MP0000015_abnormal_ear_pigmentation0.55385017
131MP0008873_increased_physiological_sensi0.54579616
132MP0002019_abnormal_tumor_incidence0.54201536
133MP0009765_abnormal_xenobiotic_induced0.54167427
134MP0005584_abnormal_enzyme/coenzyme_acti0.54006135
135MP0006036_abnormal_mitochondrial_physio0.53445825
136MP0000609_abnormal_liver_physiology0.52805374
137MP0003795_abnormal_bone_structure0.52709819
138MP0005389_reproductive_system_phenotype0.51696929
139MP0001191_abnormal_skin_condition0.51257401
140MP0002136_abnormal_kidney_physiology0.49238634
141MP0000604_amyloidosis0.48134231
142MP0010307_abnormal_tumor_latency0.48036077
143MP0004883_abnormal_blood_vessel0.47096653

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.26231600
2Optic neuritis (HP:0100653)6.19160177
3Retrobulbar optic neuritis (HP:0100654)6.19160177
4Orchitis (HP:0100796)5.92991019
5Eczematoid dermatitis (HP:0000976)5.03326082
6Elevated erythrocyte sedimentation rate (HP:0003565)4.90149387
7Abnormality of T cell number (HP:0011839)4.85038407
8Keratoconjunctivitis (HP:0001096)4.49112066
9T lymphocytopenia (HP:0005403)4.43093492
10Keratoconjunctivitis sicca (HP:0001097)4.29292421
11Autoimmune hemolytic anemia (HP:0001890)4.27582408
12Recurrent fungal infections (HP:0002841)4.27337474
13Arterial thrombosis (HP:0004420)4.22125180
14Increased IgE level (HP:0003212)4.19969616
15Stomatitis (HP:0010280)4.18782982
163-Methylglutaconic aciduria (HP:0003535)4.18433403
17Severe combined immunodeficiency (HP:0004430)3.83355164
18Pulmonary infiltrates (HP:0002113)3.80196515
19Increased IgM level (HP:0003496)3.78687281
20Autoimmune thrombocytopenia (HP:0001973)3.57195075
21Vasculitis (HP:0002633)3.48886282
22Congenital stationary night blindness (HP:0007642)3.44517634
23Hypergammaglobulinemia (HP:0010702)3.44392220
24Recurrent bronchitis (HP:0002837)3.44283267
25Abnormality of T cells (HP:0002843)3.38646401
26Pustule (HP:0200039)3.36658553
27Hypoproteinemia (HP:0003075)3.35333392
28Eosinophilia (HP:0001880)3.31739844
29Gangrene (HP:0100758)3.26711433
30Nasal polyposis (HP:0100582)3.25986543
31Combined immunodeficiency (HP:0005387)3.23573748
32Abnormality of the nasal mucosa (HP:0000433)3.22576061
33Abnormality of B cell number (HP:0010975)3.21315252
34B lymphocytopenia (HP:0010976)3.21315252
35Molar tooth sign on MRI (HP:0002419)3.20469857
36Abnormality of midbrain morphology (HP:0002418)3.20469857
37Abnormality of eosinophils (HP:0001879)3.14002463
38Recurrent viral infections (HP:0004429)3.11701820
39Joint swelling (HP:0001386)3.09280964
40Leukocytosis (HP:0001974)3.06826621
41Recurrent bacterial skin infections (HP:0005406)3.06723256
42Thrombocytosis (HP:0001894)3.05906440
43Abnormality of the pons (HP:0007361)3.04231723
44Recurrent abscess formation (HP:0002722)3.02747633
45Chronic otitis media (HP:0000389)3.02316684
46IgG deficiency (HP:0004315)3.02290585
47Gingival bleeding (HP:0000225)2.97770335
48Hemoptysis (HP:0002105)2.96151747
49Recurrent cutaneous fungal infections (HP:0011370)2.91978890
50Chronic mucocutaneous candidiasis (HP:0002728)2.91978890
51Mediastinal lymphadenopathy (HP:0100721)2.91008729
52Large for gestational age (HP:0001520)2.88237906
53Pancreatic cysts (HP:0001737)2.88021879
54Fatigue (HP:0012378)2.85680432
55Gastrointestinal infarctions (HP:0005244)2.81470001
56Encephalitis (HP:0002383)2.81354681
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.80115470
58Chronic diarrhea (HP:0002028)2.77291525
59IgA deficiency (HP:0002720)2.74933930
60Pulmonary embolism (HP:0002204)2.71194742
61Abnormality of the renal cortex (HP:0011035)2.70875905
62Granulocytopenia (HP:0001913)2.70723998
63Meningitis (HP:0001287)2.69546880
64Hypoplasia of the pons (HP:0012110)2.58355178
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58234260
66Abnormality of alanine metabolism (HP:0010916)2.58234260
67Hyperalaninemia (HP:0003348)2.58234260
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.57171824
69Abnormality of macrophages (HP:0004311)2.56897227
70Abnormality of T cell physiology (HP:0011840)2.56086680
71Duplicated collecting system (HP:0000081)2.51176618
72Purpura (HP:0000979)2.50918504
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49864778
74Recurrent skin infections (HP:0001581)2.49818427
75Chest pain (HP:0100749)2.47777651
76Lymphopenia (HP:0001888)2.47429551
77Interstitial pulmonary disease (HP:0006530)2.45892047
78Esophageal varix (HP:0002040)2.45396746
79IgM deficiency (HP:0002850)2.44824964
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44247959
81Polycythemia (HP:0001901)2.40972031
82Thyroiditis (HP:0100646)2.39629739
83Acute necrotizing encephalopathy (HP:0006965)2.31724170
84Abnormality of the pericardium (HP:0001697)2.29964667
85Abnormality of the renal collecting system (HP:0004742)2.29522320
86Petechiae (HP:0000967)2.28975951
87Keratitis (HP:0000491)2.28123645
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28096101
89Spontaneous hematomas (HP:0007420)2.27613424
90Obstructive lung disease (HP:0006536)2.24185485
91Chronic obstructive pulmonary disease (HP:0006510)2.24185485
92Mitochondrial inheritance (HP:0001427)2.21251574
93Anorexia (HP:0002039)2.21248191
94Polyneuropathy (HP:0001271)2.21164929
95Attenuation of retinal blood vessels (HP:0007843)2.19349194
96Panhypogammaglobulinemia (HP:0003139)2.19283874
97Generalized hypopigmentation of hair (HP:0011358)2.19166069
98Myocardial infarction (HP:0001658)2.16933353
99Increased CSF lactate (HP:0002490)2.16580442
100Glomerulopathy (HP:0100820)2.15982776
101Thrombophlebitis (HP:0004418)2.15358994
102Gingivitis (HP:0000230)2.14151056
103Abnormality of the renal medulla (HP:0100957)2.13619820
104Acute encephalopathy (HP:0006846)2.09322414
105Tubular atrophy (HP:0000092)2.09176749
106Periodontitis (HP:0000704)2.07414028
107Recurrent gram-negative bacterial infections (HP:0005420)2.05775769
108Nephronophthisis (HP:0000090)2.05499407
109Pancreatic fibrosis (HP:0100732)2.04682252
110Increased hepatocellular lipid droplets (HP:0006565)2.04460537
111Genetic anticipation (HP:0003743)2.03776423
112Abnormal platelet function (HP:0011869)2.01496771
113Impaired platelet aggregation (HP:0003540)2.01496771
114Absent hand (HP:0004050)2.00667844
115Abnormality of the fingertips (HP:0001211)2.00634831
116Segmental peripheral demyelination/remyelination (HP:0003481)2.00632820
117Arthralgia (HP:0002829)1.99999117
118Abnormal rod and cone electroretinograms (HP:0008323)1.99136081
119Bilateral sensorineural hearing impairment (HP:0008619)1.98997168
120Lipid accumulation in hepatocytes (HP:0006561)1.96661989
121Adactyly (HP:0009776)1.96373268
122Abnormal platelet volume (HP:0011876)1.94951943
123True hermaphroditism (HP:0010459)1.94379182
124Inflammation of the large intestine (HP:0002037)1.93075145
125Gastrointestinal stroma tumor (HP:0100723)1.91795891
126Menorrhagia (HP:0000132)1.91745827
127Progressive macrocephaly (HP:0004481)1.91329663
128Fair hair (HP:0002286)1.90968488
129Porencephaly (HP:0002132)1.90803814
130Epistaxis (HP:0000421)1.90331695
131Lymphoma (HP:0002665)1.89115928
132Optic disc pallor (HP:0000543)1.88744442
133Pendular nystagmus (HP:0012043)1.88733630
134Congenital, generalized hypertrichosis (HP:0004540)1.88339741
135Amaurosis fugax (HP:0100576)1.86721586
136Bronchitis (HP:0012387)1.86190553
137Widely spaced teeth (HP:0000687)1.85620094
138Abnormal mitochondria in muscle tissue (HP:0008316)1.84401005
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.83897267
140Osteolytic defects of the hand bones (HP:0009699)1.83897267
141Abnormality of the pleura (HP:0002103)1.82583761
142Gaze-evoked nystagmus (HP:0000640)1.82117815
143Abnormal albumin level (HP:0012116)1.81680385
144Hypoalbuminemia (HP:0003073)1.81680385
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81530707
146Increased serum lactate (HP:0002151)1.80120757
147Oligodactyly (hands) (HP:0001180)1.77519523
148Abnormal drinking behavior (HP:0030082)1.77440202
149Polydipsia (HP:0001959)1.77440202
150Hypoplasia of the thymus (HP:0000778)1.77109713
151Keratoconus (HP:0000563)1.76309393
152Increased corneal curvature (HP:0100692)1.76309393
153Abolished electroretinogram (ERG) (HP:0000550)1.74976918
154Oral leukoplakia (HP:0002745)1.74549940
155Progressive inability to walk (HP:0002505)1.72121377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.12243776
2MAP3K144.82790395
3MAP4K13.79597017
4KDR3.60796428
5RIPK13.52772186
6JAK33.50964761
7WNK42.88013374
8ADRBK22.80264327
9ZAP702.76650003
10TBK12.58849187
11PIM22.54924601
12IKBKE2.51020502
13FRK2.49489729
14IKBKB2.33007949
15TLK12.30288275
16ITK2.29867115
17CHUK2.22854068
18TYK22.21971909
19TAOK22.18098434
20JAK12.07919589
21IRAK41.98050450
22FGFR41.97490755
23MST41.88995638
24EPHB11.75078657
25CSK1.73121006
26MATK1.67716090
27STK101.56241876
28EPHA31.50328261
29LCK1.47394018
30TEC1.47164696
31STK391.44261744
32PRKCQ1.40691169
33MAPKAPK31.40683441
34BMPR21.39773185
35CAMKK21.39616039
36SYK1.39091930
37HCK1.36476919
38PTK61.33696966
39SRPK11.30832484
40FGFR31.29868735
41PIM11.29306747
42PIK3CG1.24555069
43GRK71.23834598
44PINK11.15884203
45MAP3K121.13356344
46EIF2AK31.05403248
47STK241.03659053
48KIT1.01678745
49BTK1.01647646
50WNK11.00800542
51GRK10.98754570
52LRRK20.98214096
53TSSK60.98060970
54JAK20.96641177
55CLK10.96562371
56DAPK20.96057600
57NEK90.94694359
58NLK0.93700465
59BLK0.92797499
60FES0.91158223
61ZAK0.90513222
62ERN10.89759606
63MAP4K20.83503685
64NME10.81618879
65DYRK1B0.80717125
66MAP3K50.79457060
67BCR0.76332627
68ACVR1B0.75023628
69TAOK30.74802558
70RAF10.74085902
71IRAK10.72812082
72IRAK30.72805402
73GSK3A0.71411653
74DYRK30.69998802
75LYN0.69727586
76MARK30.68800013
77TGFBR10.68330740
78MAP3K30.68276989
79PDGFRB0.67503856
80BUB10.67420454
81IGF1R0.65470655
82BMPR1B0.62855854
83PIK3CA0.60777142
84MAP3K10.60371968
85TGFBR20.59024705
86NTRK10.58818443
87CSNK1A1L0.57322612
88FER0.56509940
89PRKCH0.55213451
90SIK30.54915324
91DAPK10.54198724
92BRD40.54153931
93INSRR0.53329695
94ABL10.51493027
95WNK30.51263788
96CSNK1G20.49295984
97FLT30.48920432
98BMX0.47948465
99TYRO30.46849536
100MAPKAPK20.46299290
101VRK20.45833739
102EGFR0.44050735
103DMPK0.43285839
104PAK30.43058430
105OXSR10.42855364
106TRPM70.41403604
107ADRBK10.41148806
108ERBB30.40751314
109CDK60.40531701
110MAP3K110.39667531
111CSNK1G30.39602948
112TESK10.39585639
113PTK20.39009957
114NME20.38577674
115INSR0.37789493
116RPS6KA50.36923056
117PTK2B0.36838116
118MAP3K130.36757409
119CAMK2A0.35806250
120MAP3K80.35804221
121PRKCD0.34720232
122TNK20.33235140
123CDK120.33049043
124SCYL20.32500803
125MAP3K70.32017911
126DYRK20.31140222
127MAPK150.30627610
128TRIB30.30237895
129TAF10.29122013
130MAPK130.28990626
131GRK60.28907166
132PHKG20.28502691
133PHKG10.28502691
134PASK0.28062728
135MAP2K60.27057749
136PBK0.26975620
137EIF2AK20.25799575
138RIPK40.25627006
139STK30.23859196
140CDK90.23824093
141MAP2K30.23703834
142TAOK10.22651209
143PDK10.22511703
144EEF2K0.21062944
145MAPK30.20815337
146NUAK10.20344113
147RPS6KA40.20318655
148ALK0.20152317
149PKN10.20121536
150TIE10.20113757
151PKN20.19454933

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.93715959
2Graft-versus-host disease_Homo sapiens_hsa053324.02414548
3Autoimmune thyroid disease_Homo sapiens_hsa053203.77700034
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.47609385
5Proteasome_Homo sapiens_hsa030503.36096207
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.17004250
7Primary immunodeficiency_Homo sapiens_hsa053403.04320246
8Type I diabetes mellitus_Homo sapiens_hsa049402.85576316
9Asthma_Homo sapiens_hsa053102.74606022
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.68659187
11T cell receptor signaling pathway_Homo sapiens_hsa046602.39765453
12Measles_Homo sapiens_hsa051622.26796772
13Leishmaniasis_Homo sapiens_hsa051402.13288849
14Antigen processing and presentation_Homo sapiens_hsa046122.07104652
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04682114
16Jak-STAT signaling pathway_Homo sapiens_hsa046302.00654524
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.95866492
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94195954
19* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.93195475
20Viral myocarditis_Homo sapiens_hsa054161.90338742
21RNA polymerase_Homo sapiens_hsa030201.87479419
22Hematopoietic cell lineage_Homo sapiens_hsa046401.85153032
23Osteoclast differentiation_Homo sapiens_hsa043801.77003015
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59619314
25TNF signaling pathway_Homo sapiens_hsa046681.58809980
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56720041
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44533863
28Toxoplasmosis_Homo sapiens_hsa051451.44258797
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42906791
30Linoleic acid metabolism_Homo sapiens_hsa005911.40974908
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38272091
32One carbon pool by folate_Homo sapiens_hsa006701.32843020
33Chemokine signaling pathway_Homo sapiens_hsa040621.32776789
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31395018
35Apoptosis_Homo sapiens_hsa042101.28959948
36Rheumatoid arthritis_Homo sapiens_hsa053231.27477646
37Phototransduction_Homo sapiens_hsa047441.26308465
38Legionellosis_Homo sapiens_hsa051341.21941314
39Oxidative phosphorylation_Homo sapiens_hsa001901.19169445
40Shigellosis_Homo sapiens_hsa051311.16406721
41B cell receptor signaling pathway_Homo sapiens_hsa046621.10439981
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08598243
43Influenza A_Homo sapiens_hsa051641.08310000
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.08028405
45Malaria_Homo sapiens_hsa051441.07497987
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06774072
47Herpes simplex infection_Homo sapiens_hsa051681.05214376
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01863524
49Regulation of autophagy_Homo sapiens_hsa041401.01793890
50Pertussis_Homo sapiens_hsa051330.98948745
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98464668
52Tuberculosis_Homo sapiens_hsa051520.95133460
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94242891
54Prolactin signaling pathway_Homo sapiens_hsa049170.92964097
55Nitrogen metabolism_Homo sapiens_hsa009100.91102448
56RNA degradation_Homo sapiens_hsa030180.90135141
57Hepatitis B_Homo sapiens_hsa051610.89170091
58African trypanosomiasis_Homo sapiens_hsa051430.88684409
59Salmonella infection_Homo sapiens_hsa051320.88637909
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88410997
61Ether lipid metabolism_Homo sapiens_hsa005650.87853231
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87003195
63Sulfur metabolism_Homo sapiens_hsa009200.86193610
64Parkinsons disease_Homo sapiens_hsa050120.86007307
65Staphylococcus aureus infection_Homo sapiens_hsa051500.84906154
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.82110053
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81976104
68Basal transcription factors_Homo sapiens_hsa030220.81663330
69Acute myeloid leukemia_Homo sapiens_hsa052210.78779635
70Epstein-Barr virus infection_Homo sapiens_hsa051690.74705112
71HTLV-I infection_Homo sapiens_hsa051660.73230325
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71209455
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69565569
74Viral carcinogenesis_Homo sapiens_hsa052030.67104152
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66293725
76Small cell lung cancer_Homo sapiens_hsa052220.65606131
77Chronic myeloid leukemia_Homo sapiens_hsa052200.64793665
78HIF-1 signaling pathway_Homo sapiens_hsa040660.64293370
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63221700
80Caffeine metabolism_Homo sapiens_hsa002320.63195421
81Platelet activation_Homo sapiens_hsa046110.62748249
82Hepatitis C_Homo sapiens_hsa051600.62169714
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58570484
84Pyrimidine metabolism_Homo sapiens_hsa002400.56052483
85p53 signaling pathway_Homo sapiens_hsa041150.55909913
86Phagosome_Homo sapiens_hsa041450.54411654
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53559170
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52606133
89Amoebiasis_Homo sapiens_hsa051460.50747048
90Alzheimers disease_Homo sapiens_hsa050100.49296957
91Tryptophan metabolism_Homo sapiens_hsa003800.47851418
92Protein export_Homo sapiens_hsa030600.47422657
93Rap1 signaling pathway_Homo sapiens_hsa040150.46365765
94Spliceosome_Homo sapiens_hsa030400.44907504
95Ras signaling pathway_Homo sapiens_hsa040140.44357959
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44100892
97Purine metabolism_Homo sapiens_hsa002300.43041206
98Butanoate metabolism_Homo sapiens_hsa006500.42549545
99Steroid biosynthesis_Homo sapiens_hsa001000.42369550
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.41926233
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41859670
102FoxO signaling pathway_Homo sapiens_hsa040680.41426505
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38570449
104Pancreatic cancer_Homo sapiens_hsa052120.38178636
105Mineral absorption_Homo sapiens_hsa049780.38064098
106Arachidonic acid metabolism_Homo sapiens_hsa005900.37804154
107Adherens junction_Homo sapiens_hsa045200.37453186
108MicroRNAs in cancer_Homo sapiens_hsa052060.37255832
109MAPK signaling pathway_Homo sapiens_hsa040100.37062774
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36319627
111Ovarian steroidogenesis_Homo sapiens_hsa049130.36188902
112Chemical carcinogenesis_Homo sapiens_hsa052040.36137473
113VEGF signaling pathway_Homo sapiens_hsa043700.36073919
114Collecting duct acid secretion_Homo sapiens_hsa049660.36019958
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35420352
116Focal adhesion_Homo sapiens_hsa045100.34482869
117Proteoglycans in cancer_Homo sapiens_hsa052050.33862612
118Thyroid cancer_Homo sapiens_hsa052160.33846635
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.32483741
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32229282
121RNA transport_Homo sapiens_hsa030130.32012480
122Histidine metabolism_Homo sapiens_hsa003400.31499108
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.31198682
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31154925
125Endocytosis_Homo sapiens_hsa041440.31132465
126Prostate cancer_Homo sapiens_hsa052150.30633001
127Peroxisome_Homo sapiens_hsa041460.29968758
128Huntingtons disease_Homo sapiens_hsa050160.29746835
129Complement and coagulation cascades_Homo sapiens_hsa046100.27368211
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26505435
131ABC transporters_Homo sapiens_hsa020100.26392941
132Dorso-ventral axis formation_Homo sapiens_hsa043200.25076500
133Selenocompound metabolism_Homo sapiens_hsa004500.24251082
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23304832
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.22912697
136Vibrio cholerae infection_Homo sapiens_hsa051100.22332708
137Glycerolipid metabolism_Homo sapiens_hsa005610.22229276
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.21805370
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21619478
140Insulin resistance_Homo sapiens_hsa049310.20966527
141Lysosome_Homo sapiens_hsa041420.20526946
142Pathways in cancer_Homo sapiens_hsa052000.19414668
143Fatty acid biosynthesis_Homo sapiens_hsa000610.19096285
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18455523
145Inositol phosphate metabolism_Homo sapiens_hsa005620.18173297
146Morphine addiction_Homo sapiens_hsa050320.17794199
147Homologous recombination_Homo sapiens_hsa034400.17361896
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17293826
149Dilated cardiomyopathy_Homo sapiens_hsa054140.16886586
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15014242
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14746680
152Renal cell carcinoma_Homo sapiens_hsa052110.14671469
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.14057968

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