TNFSF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13863279
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.13863279
3antigen processing and presentation of endogenous antigen (GO:0019883)5.41048742
4negative regulation of cell killing (GO:0031342)5.05954080
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05954080
6response to type I interferon (GO:0034340)4.67434309
7type I interferon signaling pathway (GO:0060337)4.64703701
8cellular response to type I interferon (GO:0071357)4.64703701
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51065707
10response to interferon-alpha (GO:0035455)4.25540375
11detection of other organism (GO:0098543)4.20789916
12macrophage activation involved in immune response (GO:0002281)4.15329902
13surfactant homeostasis (GO:0043129)4.12921966
14response to interferon-beta (GO:0035456)4.02053099
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95994817
16detection of molecule of bacterial origin (GO:0032490)3.76371703
17positive regulation of gamma-delta T cell activation (GO:0046645)3.74549287
18detection of external biotic stimulus (GO:0098581)3.73254691
19negative regulation of interleukin-12 production (GO:0032695)3.59940316
20lymph vessel development (GO:0001945)3.59200420
21neutrophil activation involved in immune response (GO:0002283)3.58502956
22T cell migration (GO:0072678)3.54559816
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.45613482
24positive regulation of interferon-alpha production (GO:0032727)3.45368225
25regulation of interferon-alpha production (GO:0032647)3.45108806
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43035579
27negative regulation of T cell mediated immunity (GO:0002710)3.40940774
28cellular response to exogenous dsRNA (GO:0071360)3.32070858
29cellular response to interferon-beta (GO:0035458)3.30692147
30T-helper 1 type immune response (GO:0042088)3.29009934
31positive regulation of type 2 immune response (GO:0002830)3.28736881
32lymphocyte chemotaxis (GO:0048247)3.27569162
33regulation of RIG-I signaling pathway (GO:0039535)3.26826345
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25447276
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25006906
36negative regulation of viral genome replication (GO:0045071)3.24791532
37microglial cell activation (GO:0001774)3.23913076
38positive regulation of vasculogenesis (GO:2001214)3.21300353
39detection of biotic stimulus (GO:0009595)3.18966143
40B cell mediated immunity (GO:0019724)3.14736497
41positive regulation of tolerance induction (GO:0002645)3.11112300
42positive regulation by symbiont of host defense response (GO:0052509)3.10264951
43modulation by symbiont of host defense response (GO:0052031)3.10264951
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10264951
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10264951
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.10264951
47modulation by symbiont of host immune response (GO:0052553)3.10264951
48negative regulation of leukocyte mediated immunity (GO:0002704)3.06320141
49vascular endothelial growth factor signaling pathway (GO:0038084)3.06272162
50chemical homeostasis within a tissue (GO:0048875)3.05749819
51cellular response to interferon-gamma (GO:0071346)3.05670724
52production of molecular mediator involved in inflammatory response (GO:0002532)3.04401484
53dendritic cell chemotaxis (GO:0002407)3.04082511
54macrophage activation (GO:0042116)3.03222501
55interferon-gamma-mediated signaling pathway (GO:0060333)3.02995772
56response to host defenses (GO:0052200)3.00617485
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00617485
58response to host (GO:0075136)3.00617485
59regulation of T cell mediated cytotoxicity (GO:0001914)2.98865869
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97882620
61regulation of vasculogenesis (GO:2001212)2.97778902
62response to interferon-gamma (GO:0034341)2.95269789
63regulation of type 2 immune response (GO:0002828)2.94646788
64interferon-gamma production (GO:0032609)2.92652889
65blood vessel maturation (GO:0001955)2.92359255
66positive regulation of natural killer cell differentiation (GO:0032825)2.91240141
67regulation of gamma-delta T cell activation (GO:0046643)2.89765899
68regulation of endothelial cell differentiation (GO:0045601)2.88694760
69myeloid cell activation involved in immune response (GO:0002275)2.88235397
70dendritic cell migration (GO:0036336)2.87616787
71negative regulation of nitric oxide biosynthetic process (GO:0045019)2.87107403
72regulation of gamma-delta T cell differentiation (GO:0045586)2.86198794
73negative regulation of innate immune response (GO:0045824)2.86132902
74interferon-gamma secretion (GO:0072643)2.86093169
75neutrophil activation (GO:0042119)2.85138251
76regulation of T cell tolerance induction (GO:0002664)2.83692777
77retina vasculature morphogenesis in camera-type eye (GO:0061299)2.82566845
78negative regulation of type 2 immune response (GO:0002829)2.78902940
79JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.78033839
80endothelial tube morphogenesis (GO:0061154)2.77405938
81morphogenesis of an endothelium (GO:0003159)2.77405938
82cytidine deamination (GO:0009972)2.77292048
83cytidine metabolic process (GO:0046087)2.77292048
84cytidine catabolic process (GO:0006216)2.77292048
85endothelium development (GO:0003158)2.76598301
86regulation of MHC class I biosynthetic process (GO:0045343)2.76447014
87regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.76149360
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75799192
89regulation of regulatory T cell differentiation (GO:0045589)2.72551204
90response to protozoan (GO:0001562)2.71311586
91negative regulation of cytokine production involved in immune response (GO:0002719)2.70346811
92granulocyte activation (GO:0036230)2.70297723
93cellular response to interferon-alpha (GO:0035457)2.69529811
94defense response to protozoan (GO:0042832)2.69389373
95response to interleukin-15 (GO:0070672)2.68774240
96tolerance induction (GO:0002507)2.68024662
97defense response to virus (GO:0051607)2.66119184
98respiratory burst (GO:0045730)2.65293817
99positive regulation of defense response to virus by host (GO:0002230)2.64022397
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63946954
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62096850
102regulation of immunoglobulin secretion (GO:0051023)2.60972467
103antigen processing and presentation via MHC class Ib (GO:0002475)2.60917453
104positive regulation of antigen processing and presentation (GO:0002579)2.55948853
105definitive hemopoiesis (GO:0060216)2.55902205
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55298612
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.54921050
108regulation of response to interferon-gamma (GO:0060330)2.54104266
109positive regulation of humoral immune response (GO:0002922)2.53987222
110cellular response to virus (GO:0098586)2.53925664
111response to peptidoglycan (GO:0032494)2.53672963
112myeloid dendritic cell activation (GO:0001773)2.53035086
113negative T cell selection (GO:0043383)2.53005721
114cellular response to interleukin-15 (GO:0071350)2.52592341
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48997087
116response to host immune response (GO:0052572)2.48579472
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48579472
118negative thymic T cell selection (GO:0045060)2.45837455
119immunoglobulin mediated immune response (GO:0016064)2.44973007
120positive regulation of interferon-beta production (GO:0032728)2.43281279
121regulation of interferon-beta biosynthetic process (GO:0045357)2.43134250
122establishment of endothelial barrier (GO:0061028)2.42919049
123myeloid dendritic cell differentiation (GO:0043011)2.41378867
124positive regulation of toll-like receptor signaling pathway (GO:0034123)2.40338826
125regulation of antigen processing and presentation (GO:0002577)2.40068248
126regulation of alpha-beta T cell proliferation (GO:0046640)2.39745825
127positive regulation of interleukin-17 production (GO:0032740)2.39530959
128regulation of natural killer cell differentiation (GO:0032823)2.38832418
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38698166
130regulation of T-helper 1 cell differentiation (GO:0045625)2.38638222
131cellular extravasation (GO:0045123)2.38615061
132CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.38582745
133T-helper cell differentiation (GO:0042093)2.38582745
134positive regulation of endothelial cell differentiation (GO:0045603)2.37505589
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37245632
136detection of bacterium (GO:0016045)2.37070662
137leukocyte aggregation (GO:0070486)2.36253674
138response to muramyl dipeptide (GO:0032495)2.35926395
139regulation of tolerance induction (GO:0002643)2.35556419
140regulation of B cell receptor signaling pathway (GO:0050855)2.34932268
141regulation of activation of Janus kinase activity (GO:0010533)2.34621663
142regulation of cellular extravasation (GO:0002691)2.34318934
143CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.33834327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.49174892
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.92758161
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.60282674
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.72177193
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.37838387
6GATA1_22025678_ChIP-Seq_K562_Human4.27707164
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26151802
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.19560528
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.84692453
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79763217
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.77810041
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.77174674
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74245881
14SCL_19346495_ChIP-Seq_HPC-7_Human2.56894051
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46944902
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44912755
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41431899
18* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37827679
19* GATA2_21666600_ChIP-Seq_HMVEC_Human2.37167102
20RUNX_20019798_ChIP-Seq_JUKART_Human2.32370805
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17756753
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.16142627
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.97269340
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96219810
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91133904
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89458091
27* MYB_26560356_Chip-Seq_TH2_Human1.87201577
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85169120
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.80215375
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78410750
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73014544
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72944851
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71539230
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.67218554
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66061524
36MYB_26560356_Chip-Seq_TH1_Human1.57618491
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57604386
38* MAF_26560356_Chip-Seq_TH1_Human1.48328337
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48062730
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45757833
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42880074
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.39552228
43* SPI1_23547873_ChIP-Seq_NB4_Human1.37961274
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31978938
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30827805
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.28994353
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28229866
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28175963
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28126891
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.25082475
51* SOX2_20726797_ChIP-Seq_SW620_Human1.22122662
52PU_27001747_Chip-Seq_BMDM_Mouse1.15136126
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13519370
54* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12826858
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11970420
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11805955
57* GATA3_26560356_Chip-Seq_TH2_Human1.11516931
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.11359714
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10328938
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09831064
61VDR_24787735_ChIP-Seq_THP-1_Human1.07301790
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.06392765
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05015535
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04185482
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.03273606
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.02855386
67UTX_26944678_Chip-Seq_JUKART_Human1.02233484
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01816835
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00147365
70VDR_21846776_ChIP-Seq_THP-1_Human0.97423369
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97268396
72SPI1_23127762_ChIP-Seq_K562_Human0.95761317
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95429395
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95326978
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94942886
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90976785
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90105253
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90076377
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89779882
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89570842
81TCF7_22412390_ChIP-Seq_EML_Mouse0.88930438
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85959510
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85482658
84PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84810265
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.84639178
86P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84469417
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.84366661
88GATA1_19941826_ChIP-Seq_K562_Human0.84067214
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84001817
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83797395
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83628671
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83595788
93* GATA2_19941826_ChIP-Seq_K562_Human0.83504499
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.83086493
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82625742
96VDR_24763502_ChIP-Seq_THP-1_Human0.82017242
97GATA4_25053715_ChIP-Seq_YYC3_Human0.82004787
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81722964
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81265264
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80139375
101STAT1_20625510_ChIP-Seq_HELA_Human0.80024420
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79609855
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79602652
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.77898623
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.77548001
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76712320
107SMRT_27268052_Chip-Seq_Bcells_Human0.75919030
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74886301
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74773452
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73702798
111EGR1_19032775_ChIP-ChIP_M12_Human0.73545099
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73357997
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.72738186
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.72661253
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72390532
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72306232
117MAF_26560356_Chip-Seq_TH2_Human0.71026825
118* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70257314
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69440546
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69208451
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69177401
122BCL6_27268052_Chip-Seq_Bcells_Human0.69006983
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68766849
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66880769
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66788422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003724_increased_susceptibility_to3.63060402
2MP0001835_abnormal_antigen_presentation3.33568778
3* MP0009785_altered_susceptibility_to3.17058880
4MP0010368_abnormal_lymphatic_system2.95641139
5MP0005671_abnormal_response_to2.91828047
6MP0005360_urolithiasis2.80163296
7MP0001879_abnormal_lymphatic_vessel2.67297815
8MP0002138_abnormal_hepatobiliary_system2.52531731
9MP0001790_abnormal_immune_system2.49316869
10MP0005387_immune_system_phenotype2.49316869
11MP0000685_abnormal_immune_system2.43726737
12* MP0005025_abnormal_response_to2.39942123
13MP0002148_abnormal_hypersensitivity_rea2.26505029
14MP0005167_abnormal_blood-brain_barrier2.13392174
15MP0002166_altered_tumor_susceptibility2.12900034
16* MP0001800_abnormal_humoral_immune2.06856192
17MP0004782_abnormal_surfactant_physiolog2.06724671
18* MP0005000_abnormal_immune_tolerance2.00855313
19MP0003763_abnormal_thymus_physiology2.00105068
20MP0004510_myositis1.99656968
21* MP0002723_abnormal_immune_serum1.97572425
22MP0006082_CNS_inflammation1.96942863
23MP0003191_abnormal_cellular_cholesterol1.96648299
24MP0003183_abnormal_peptide_metabolism1.94239664
25MP0001853_heart_inflammation1.93372385
26MP0003436_decreased_susceptibility_to1.93127513
27MP0003300_gastrointestinal_ulcer1.89801354
28MP0002419_abnormal_innate_immunity1.89690734
29MP0009764_decreased_sensitivity_to1.88495068
30MP0010155_abnormal_intestine_physiology1.87971305
31* MP0002452_abnormal_antigen_presenting1.85165817
32MP0008875_abnormal_xenobiotic_pharmacok1.84475566
33MP0002006_tumorigenesis1.84436950
34MP0002139_abnormal_hepatobiliary_system1.80244018
35* MP0001819_abnormal_immune_cell1.75289938
36MP0003828_pulmonary_edema1.74425227
37* MP0002420_abnormal_adaptive_immunity1.73745979
38MP0005464_abnormal_platelet_physiology1.69519050
39MP0001873_stomach_inflammation1.61663266
40MP0008469_abnormal_protein_level1.60689959
41MP0005085_abnormal_gallbladder_physiolo1.59530537
42MP0004947_skin_inflammation1.50647375
43* MP0001845_abnormal_inflammatory_respons1.50159012
44MP0005166_decreased_susceptibility_to1.48612472
45MP0002405_respiratory_system_inflammati1.41744178
46MP0000465_gastrointestinal_hemorrhage1.41164946
47* MP0000716_abnormal_immune_system1.40807841
48MP0003303_peritoneal_inflammation1.36837855
49MP0005365_abnormal_bile_salt1.36632070
50* MP0002398_abnormal_bone_marrow1.35462634
51MP0008260_abnormal_autophagy1.31986989
52MP0000343_altered_response_to1.30177975
53MP0002277_abnormal_respiratory_mucosa1.29691489
54MP0009333_abnormal_splenocyte_physiolog1.28477113
55MP0003866_abnormal_defecation1.28460513
56MP0003195_calcinosis1.27853299
57MP0003075_altered_response_to1.27540356
58MP0002396_abnormal_hematopoietic_system1.26249791
59MP0005451_abnormal_body_composition1.23308148
60MP0003252_abnormal_bile_duct1.21309951
61MP0001545_abnormal_hematopoietic_system1.18045145
62MP0005397_hematopoietic_system_phenotyp1.18045145
63MP0004883_abnormal_blood_vessel1.17903251
64MP0000249_abnormal_blood_vessel1.17636718
65* MP0002429_abnormal_blood_cell1.16316824
66* MP0001533_abnormal_skeleton_physiology1.13871486
67* MP0003448_altered_tumor_morphology1.13779843
68MP0002132_abnormal_respiratory_system1.13727960
69MP0000689_abnormal_spleen_morphology1.13038819
70MP0004808_abnormal_hematopoietic_stem1.12923470
71MP0009643_abnormal_urine_homeostasis1.11390335
72MP0004147_increased_porphyrin_level1.09510446
73MP0005165_increased_susceptibility_to1.08889202
74MP0009379_abnormal_foot_pigmentation1.08723236
75* MP0002722_abnormal_immune_system1.08706968
76* MP0009763_increased_sensitivity_to1.08265640
77MP0009840_abnormal_foam_cell1.06784683
78MP0003690_abnormal_glial_cell1.05433027
79MP0003172_abnormal_lysosome_physiology1.02096724
80MP0003806_abnormal_nucleotide_metabolis0.99054159
81MP0001663_abnormal_digestive_system0.98802182
82MP0001851_eye_inflammation0.98507849
83MP0010329_abnormal_lipoprotein_level0.97370111
84MP0002136_abnormal_kidney_physiology0.97304521
85MP0009278_abnormal_bone_marrow0.94654762
86MP0005310_abnormal_salivary_gland0.94029898
87MP0001666_abnormal_nutrient_absorption0.89740440
88MP0000604_amyloidosis0.89594859
89MP0004272_abnormal_basement_membrane0.89488441
90MP0005408_hypopigmentation0.89356043
91MP0005164_abnormal_response_to0.88596586
92MP0010234_abnormal_vibrissa_follicle0.88449838
93MP0003943_abnormal_hepatobiliary_system0.87690971
94MP0003186_abnormal_redox_activity0.87658327
95MP0000767_abnormal_smooth_muscle0.86917538
96MP0002998_abnormal_bone_remodeling0.86906782
97MP0004381_abnormal_hair_follicle0.86639845
98MP0003045_fibrosis0.86036354
99MP0005058_abnormal_lysosome_morphology0.85913554
100MP0001958_emphysema0.83957805
101* MP0000609_abnormal_liver_physiology0.83861554
102MP0009765_abnormal_xenobiotic_induced0.81949459
103MP0001764_abnormal_homeostasis0.81027018
104MP0005332_abnormal_amino_acid0.80881112
105MP0009697_abnormal_copulation0.80665314
106MP0005319_abnormal_enzyme/_coenzyme0.79516720
107MP0005409_darkened_coat_color0.79299696
108MP0004264_abnormal_extraembryonic_tissu0.79260694
109MP0004019_abnormal_vitamin_homeostasis0.78440016
110* MP0000703_abnormal_thymus_morphology0.77345516
111MP0005084_abnormal_gallbladder_morpholo0.76295990
112MP0006054_spinal_hemorrhage0.76057933
113MP0000858_altered_metastatic_potential0.75007422
114MP0001765_abnormal_ion_homeostasis0.74509897
115MP0002933_joint_inflammation0.74421146
116MP0008004_abnormal_stomach_pH0.73620151
117MP0005379_endocrine/exocrine_gland_phen0.70595771
118* MP0005390_skeleton_phenotype0.69472769
119MP0003656_abnormal_erythrocyte_physiolo0.66466275
120MP0002876_abnormal_thyroid_physiology0.66181957
121MP0005584_abnormal_enzyme/coenzyme_acti0.64428003
122MP0003453_abnormal_keratinocyte_physiol0.63614616

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)4.30034238
2Abnormality of the nasal mucosa (HP:0000433)3.92986846
3Chronic otitis media (HP:0000389)3.74260166
4Eczematoid dermatitis (HP:0000976)3.60348059
5Elevated erythrocyte sedimentation rate (HP:0003565)3.59962499
6Myositis (HP:0100614)3.54877873
7Autoimmune thrombocytopenia (HP:0001973)3.43447330
8Polycythemia (HP:0001901)3.41694768
9Orchitis (HP:0100796)3.40933589
10Retrobulbar optic neuritis (HP:0100654)3.32421671
11Optic neuritis (HP:0100653)3.32421671
12Recurrent bronchitis (HP:0002837)3.25886752
13Esophageal varix (HP:0002040)3.21053529
14Hematochezia (HP:0002573)3.12193978
15Joint hemorrhage (HP:0005261)3.10459571
16Malnutrition (HP:0004395)3.09715046
17Increased IgM level (HP:0003496)3.07309071
18Prolonged bleeding time (HP:0003010)3.05737128
19Autoimmune hemolytic anemia (HP:0001890)3.01073012
20Interstitial pulmonary disease (HP:0006530)2.96555958
21Recurrent abscess formation (HP:0002722)2.91184898
22Hemoptysis (HP:0002105)2.89355278
23Vasculitis (HP:0002633)2.87282458
24Recurrent fungal infections (HP:0002841)2.86689869
25Abnormality of T cell number (HP:0011839)2.86518157
26Pulmonary embolism (HP:0002204)2.84357519
27Recurrent viral infections (HP:0004429)2.80428707
28Urticaria (HP:0001025)2.77037957
29Epistaxis (HP:0000421)2.76123079
30Gingival bleeding (HP:0000225)2.74576125
31T lymphocytopenia (HP:0005403)2.74217100
32Chest pain (HP:0100749)2.71840238
33Menorrhagia (HP:0000132)2.68625294
34Abnormality of macrophages (HP:0004311)2.67641419
35Recurrent bacterial skin infections (HP:0005406)2.66771141
36Nasal polyposis (HP:0100582)2.62437277
37Abnormality of T cells (HP:0002843)2.60925928
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.60079419
39Purpura (HP:0000979)2.59672745
40Hyperactive renin-angiotensin system (HP:0000841)2.59553565
41Recurrent cutaneous fungal infections (HP:0011370)2.56928074
42Chronic mucocutaneous candidiasis (HP:0002728)2.56928074
43Peritonitis (HP:0002586)2.53081130
44Petechiae (HP:0000967)2.52805659
45Amyloidosis (HP:0011034)2.52684585
46IgM deficiency (HP:0002850)2.51823494
47Abnormality of T cell physiology (HP:0011840)2.51267036
48Anorexia (HP:0002039)2.50559397
49Microcytic anemia (HP:0001935)2.47975569
50Abnormality of eosinophils (HP:0001879)2.45468353
51Mediastinal lymphadenopathy (HP:0100721)2.44579448
52Cheilitis (HP:0100825)2.44376950
53Pulmonary infiltrates (HP:0002113)2.42240076
54Hemorrhage of the eye (HP:0011885)2.42052787
55Abnormality of the pleura (HP:0002103)2.41065678
56IgG deficiency (HP:0004315)2.41040077
57Pustule (HP:0200039)2.40812034
58Joint swelling (HP:0001386)2.39895538
59Eosinophilia (HP:0001880)2.38972852
60Meningitis (HP:0001287)2.38943889
61Keratoconjunctivitis sicca (HP:0001097)2.38092587
62Encephalitis (HP:0002383)2.38009353
63Thrombophlebitis (HP:0004418)2.37193656
64Stomatitis (HP:0010280)2.37180283
65Recurrent skin infections (HP:0001581)2.34087262
66Granulocytopenia (HP:0001913)2.31840479
67Portal hypertension (HP:0001409)2.31719737
68Episodic fever (HP:0001954)2.28916626
69Recurrent gram-negative bacterial infections (HP:0005420)2.27958362
70Inflammation of the large intestine (HP:0002037)2.26760474
71Arterial thrombosis (HP:0004420)2.26244627
72Chronic sinusitis (HP:0011109)2.24501268
73Chronic diarrhea (HP:0002028)2.24315648
74Glomerulonephritis (HP:0000099)2.23599486
75Keratoconjunctivitis (HP:0001096)2.22777945
76Gangrene (HP:0100758)2.22555602
77Abnormality of the prostate (HP:0008775)2.21705512
78Hypergammaglobulinemia (HP:0010702)2.20307955
79IgA deficiency (HP:0002720)2.20060065
80Periodontitis (HP:0000704)2.19533120
81Severe combined immunodeficiency (HP:0004430)2.18918229
82Bronchitis (HP:0012387)2.17592281
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16642557
84Abnormal platelet function (HP:0011869)2.16406993
85Impaired platelet aggregation (HP:0003540)2.16406993
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15731467
87Porencephaly (HP:0002132)2.15696990
88Gastrointestinal infarctions (HP:0005244)2.14826572
89Basal ganglia calcification (HP:0002135)2.14374700
90Leukocytosis (HP:0001974)2.14150284
91Complement deficiency (HP:0004431)2.13387853
92Skin rash (HP:0000988)2.12761390
93Gastrointestinal inflammation (HP:0004386)2.11574213
94Premature loss of primary teeth (HP:0006323)2.10438150
95Prolonged partial thromboplastin time (HP:0003645)2.10345494
96Abnormality of the hepatic vasculature (HP:0006707)2.09840224
97Pulmonary artery stenosis (HP:0004415)2.09513547
98Abnormality of liposaccharide metabolism (HP:0010968)2.08998259
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.08998259
100Abnormality of glycolipid metabolism (HP:0010969)2.08998259
101Hypochromic anemia (HP:0001931)2.08708341
102Vacuolated lymphocytes (HP:0001922)2.08191299
103Acne (HP:0001061)2.07912024
104Systemic lupus erythematosus (HP:0002725)2.07592972
105Colitis (HP:0002583)2.06809914
106Cellulitis (HP:0100658)2.05182694
107Conjugated hyperbilirubinemia (HP:0002908)2.05146860
108Abnormality of the endocardium (HP:0004306)2.04484692
109Osteomyelitis (HP:0002754)2.04174182
110Abnormality of complement system (HP:0005339)2.04077176
111Obstructive lung disease (HP:0006536)2.03570652
112Chronic obstructive pulmonary disease (HP:0006510)2.03570652
113Loss of speech (HP:0002371)2.03351336
114Increased IgE level (HP:0003212)2.02527011
115Abnormal platelet volume (HP:0011876)2.02275198
116Panhypogammaglobulinemia (HP:0003139)2.01069762
117Conjunctival telangiectasia (HP:0000524)1.99526927
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99482775
119Hypokalemic alkalosis (HP:0001949)1.98641918
120Pigmentary retinal degeneration (HP:0001146)1.96988619
121Agammaglobulinemia (HP:0004432)1.96166785
122Abnormality of the pericardium (HP:0001697)1.95540695
123Cerebral hemorrhage (HP:0001342)1.95063985
124Stomach cancer (HP:0012126)1.94718049
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94606791
126Deep venous thrombosis (HP:0002625)1.94107842
127Skin ulcer (HP:0200042)1.93549635
128Thrombocytosis (HP:0001894)1.93295275
129Glomerulopathy (HP:0100820)1.91748288
130Combined immunodeficiency (HP:0005387)1.91659571
131Gingivitis (HP:0000230)1.90754308
132Thyroiditis (HP:0100646)1.90552492
133Hypoproteinemia (HP:0003075)1.90053623
134Vertigo (HP:0002321)1.89146604
135Acute hepatic failure (HP:0006554)1.88764307
136Alveolar cell carcinoma (HP:0006519)1.88648188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.35913608
2TXK3.90332073
3KDR3.81287810
4RIPK43.58287014
5TYK23.07045733
6MAP4K12.95214422
7IKBKE2.87782623
8FGFR42.76688172
9MAP3K142.66776615
10IRAK32.53152881
11JAK32.51586119
12TGFBR22.46052019
13KIT2.25396321
14TBK12.14504861
15JAK12.07688618
16IRAK41.98862350
17TEC1.87717136
18TAOK31.85436152
19FGFR31.75864336
20EPHB11.72955063
21ZAP701.60829503
22TGFBR11.56645700
23MST41.52738967
24NLK1.48515106
25FGR1.44386260
26IKBKB1.42373097
27CSK1.40959728
28PRPF4B1.36766111
29EPHA31.36678183
30IRAK11.33626725
31GRK11.31010921
32ACVR1B1.27904671
33NUAK11.26481072
34ITK1.25519151
35LMTK21.22737994
36BLK1.19962036
37STK101.18986427
38BTK1.15636177
39MAP3K11.11944841
40LCK1.09181606
41MYLK1.08784481
42MAP3K21.07696975
43TAOK11.06602467
44NEK91.03864397
45SIK30.97158108
46INSRR0.96603337
47NME20.94959589
48CHUK0.93710815
49JAK20.89614094
50MAP3K110.87355541
51STK160.86748311
52HCK0.84161284
53SYK0.83856200
54FRK0.82904061
55MAP2K30.81399024
56FES0.79618863
57CDC42BPA0.79571016
58ERN10.78570042
59PIM10.74439212
60HIPK20.73034461
61PIM20.70564361
62PDK10.70279755
63LYN0.70202648
64PRKG20.70126378
65PBK0.67869468
66GRK70.67854207
67PRKCQ0.67807930
68MAPK150.67252412
69MAP3K60.66107379
70PIK3CG0.65494039
71EIF2AK20.64681877
72MAP3K120.64608663
73ADRBK20.61454926
74KSR20.60440507
75FER0.60164944
76PDPK10.60022273
77LRRK20.59708440
78BCKDK0.58196242
79PTK60.57481741
80MATK0.56693647
81MAPK110.55493910
82MARK30.54771475
83STK40.54634895
84PRKAA20.54088329
85MAPK70.53295797
86TESK20.53095127
87IRAK20.53090342
88FYN0.52807350
89RPS6KA40.51659557
90MUSK0.51627299
91PRKD20.48621544
92RIPK10.48318609
93MAP2K60.47345099
94YES10.47321975
95BMPR1B0.45494493
96EPHB20.45065008
97ZAK0.44623232
98BMPR20.44086199
99MAPK40.43872138
100RET0.43253923
101PTK2B0.42987953
102CDK90.42879639
103MAP3K130.41320006
104STK240.41223180
105IGF1R0.40910877
106MAP3K70.40667007
107TNK20.40513920
108GRK60.40127172
109OXSR10.39861114
110MAP3K50.38879674
111ABL10.38678166
112MAPKAPK20.37258965
113CSF1R0.36927494
114TRPM70.36917627
115TNIK0.36911467
116FLT30.36575042
117MARK20.36217111
118CLK10.36160770
119MST1R0.36073933
120MAP3K30.34761499
121TAOK20.31938046
122CDK60.31789742
123STK380.31317176
124EGFR0.30326379
125DAPK20.28869703
126PRKCD0.28174857
127CDK40.27994050
128PIK3CA0.27083118
129RPS6KA50.26698458
130CAMKK20.26274317
131WNK40.24626988

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.01912464
2Primary immunodeficiency_Homo sapiens_hsa053402.95977178
3Caffeine metabolism_Homo sapiens_hsa002322.88460026
4Allograft rejection_Homo sapiens_hsa053302.81549997
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.74316335
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61563898
7Staphylococcus aureus infection_Homo sapiens_hsa051502.49863359
8* Measles_Homo sapiens_hsa051622.33232900
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.32613128
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.32416136
11Graft-versus-host disease_Homo sapiens_hsa053322.21893087
12Leishmaniasis_Homo sapiens_hsa051402.10648979
13Asthma_Homo sapiens_hsa053102.00392938
14Autoimmune thyroid disease_Homo sapiens_hsa053201.95722233
15Hematopoietic cell lineage_Homo sapiens_hsa046401.94206865
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91002574
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72067224
18Malaria_Homo sapiens_hsa051441.70054557
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.69220672
20* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68469085
21African trypanosomiasis_Homo sapiens_hsa051431.58987199
22Herpes simplex infection_Homo sapiens_hsa051681.54018355
23Pertussis_Homo sapiens_hsa051331.53564500
24* Influenza A_Homo sapiens_hsa051641.52347398
25Complement and coagulation cascades_Homo sapiens_hsa046101.51602190
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.50650252
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47649945
28Toxoplasmosis_Homo sapiens_hsa051451.43381529
29Osteoclast differentiation_Homo sapiens_hsa043801.39157698
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36152434
31TNF signaling pathway_Homo sapiens_hsa046681.33802203
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31916318
33Antigen processing and presentation_Homo sapiens_hsa046121.31621207
34Tryptophan metabolism_Homo sapiens_hsa003801.31012254
35Hepatitis C_Homo sapiens_hsa051601.25944335
36Vitamin digestion and absorption_Homo sapiens_hsa049771.25468809
37Histidine metabolism_Homo sapiens_hsa003401.24749579
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20973616
39Peroxisome_Homo sapiens_hsa041461.18810238
40T cell receptor signaling pathway_Homo sapiens_hsa046601.10593989
41ABC transporters_Homo sapiens_hsa020101.09871454
42Rheumatoid arthritis_Homo sapiens_hsa053231.08508007
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04879612
44* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04438106
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01799490
46Legionellosis_Homo sapiens_hsa051341.01265306
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.00969489
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99308009
49Phagosome_Homo sapiens_hsa041450.98666697
50Viral myocarditis_Homo sapiens_hsa054160.98133028
51Fatty acid degradation_Homo sapiens_hsa000710.97219479
52beta-Alanine metabolism_Homo sapiens_hsa004100.89585033
53B cell receptor signaling pathway_Homo sapiens_hsa046620.85219659
54Ribosome_Homo sapiens_hsa030100.79567023
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79534061
56Chemokine signaling pathway_Homo sapiens_hsa040620.76496281
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76431267
58Retinol metabolism_Homo sapiens_hsa008300.76325745
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75364231
60Tuberculosis_Homo sapiens_hsa051520.75073287
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75003424
62Chemical carcinogenesis_Homo sapiens_hsa052040.74693843
63Renin-angiotensin system_Homo sapiens_hsa046140.74006684
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73717887
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73287624
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.72909010
67Other glycan degradation_Homo sapiens_hsa005110.72184175
68PPAR signaling pathway_Homo sapiens_hsa033200.71581346
69Platelet activation_Homo sapiens_hsa046110.67751074
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.66732020
71Hepatitis B_Homo sapiens_hsa051610.66682868
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66505409
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.66347543
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.64620604
75Lysosome_Homo sapiens_hsa041420.60685638
76Linoleic acid metabolism_Homo sapiens_hsa005910.60619224
77* Apoptosis_Homo sapiens_hsa042100.60427071
78Folate biosynthesis_Homo sapiens_hsa007900.60226773
79Type I diabetes mellitus_Homo sapiens_hsa049400.57886491
80Notch signaling pathway_Homo sapiens_hsa043300.57077731
81Pancreatic cancer_Homo sapiens_hsa052120.56694226
82Arginine biosynthesis_Homo sapiens_hsa002200.54687711
83Dorso-ventral axis formation_Homo sapiens_hsa043200.54298216
84Prolactin signaling pathway_Homo sapiens_hsa049170.53894863
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52540943
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52163738
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51582035
88Small cell lung cancer_Homo sapiens_hsa052220.51424155
89Starch and sucrose metabolism_Homo sapiens_hsa005000.50809070
90Salmonella infection_Homo sapiens_hsa051320.50226659
91Sphingolipid metabolism_Homo sapiens_hsa006000.49965348
92Insulin resistance_Homo sapiens_hsa049310.48380451
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47740597
94Bile secretion_Homo sapiens_hsa049760.46719025
95Mineral absorption_Homo sapiens_hsa049780.46187602
96Acute myeloid leukemia_Homo sapiens_hsa052210.45776445
97Propanoate metabolism_Homo sapiens_hsa006400.44371264
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42254268
99Sulfur metabolism_Homo sapiens_hsa009200.42223520
100Fatty acid elongation_Homo sapiens_hsa000620.41946492
101Shigellosis_Homo sapiens_hsa051310.41701368
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40810353
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.40515352
104Non-small cell lung cancer_Homo sapiens_hsa052230.39055290
105Fat digestion and absorption_Homo sapiens_hsa049750.38106989
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36237549
107Glycerolipid metabolism_Homo sapiens_hsa005610.35868342
108VEGF signaling pathway_Homo sapiens_hsa043700.34910846
109Arachidonic acid metabolism_Homo sapiens_hsa005900.34307528
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.34132057
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33418424
112ECM-receptor interaction_Homo sapiens_hsa045120.33085580
113Endocytosis_Homo sapiens_hsa041440.32564744
114Arginine and proline metabolism_Homo sapiens_hsa003300.31893783
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.31012355
116Galactose metabolism_Homo sapiens_hsa000520.30555392
117Amoebiasis_Homo sapiens_hsa051460.30513867
118Lysine degradation_Homo sapiens_hsa003100.30231473
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30094712
120Pancreatic secretion_Homo sapiens_hsa049720.29498226

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