TNFSF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)6.81700378
2regulation of memory T cell differentiation (GO:0043380)6.45832304
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.42583320
4interferon-gamma production (GO:0032609)6.12934556
5response to interleukin-15 (GO:0070672)6.09991703
6regulation of gamma-delta T cell differentiation (GO:0045586)6.07735529
7cellular response to interleukin-15 (GO:0071350)5.92821260
8positive regulation of T cell cytokine production (GO:0002726)5.82762199
9regulation of interleukin-12 biosynthetic process (GO:0045075)5.81748292
10regulation of B cell receptor signaling pathway (GO:0050855)5.71362109
11positive regulation of interleukin-17 production (GO:0032740)5.58059305
12regulation of gamma-delta T cell activation (GO:0046643)5.40002940
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.33806899
14negative regulation of cell killing (GO:0031342)5.29822303
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.29822303
16NIK/NF-kappaB signaling (GO:0038061)5.14963391
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.09923699
18regulation of activation of Janus kinase activity (GO:0010533)5.00020235
19negative T cell selection (GO:0043383)4.98538569
20negative thymic T cell selection (GO:0045060)4.96603471
21T-helper cell differentiation (GO:0042093)4.95979585
22CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.95979585
23regulation of isotype switching to IgG isotypes (GO:0048302)4.92468211
24positive regulation of gamma-delta T cell activation (GO:0046645)4.83130216
25positive thymic T cell selection (GO:0045059)4.79773233
26positive regulation of activated T cell proliferation (GO:0042104)4.67211867
27regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.66734183
28DNA deamination (GO:0045006)4.52744106
29tyrosine phosphorylation of STAT protein (GO:0007260)4.52668961
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.50966944
31regulation of mitotic spindle checkpoint (GO:1903504)4.50966944
32endothelial cell chemotaxis (GO:0035767)4.43463181
33regulation of immunoglobulin secretion (GO:0051023)4.40546721
34thymic T cell selection (GO:0045061)4.38045138
35alpha-beta T cell differentiation (GO:0046632)4.36341512
36alpha-beta T cell differentiation involved in immune response (GO:0002293)4.34553983
37alpha-beta T cell activation involved in immune response (GO:0002287)4.34553983
38T cell differentiation involved in immune response (GO:0002292)4.34553983
39regulation of T cell mediated cytotoxicity (GO:0001914)4.28292362
40regulation of regulatory T cell differentiation (GO:0045589)4.27884877
41positive regulation of cell fate commitment (GO:0010455)4.24899060
42positive regulation of T cell mediated cytotoxicity (GO:0001916)4.20626614
43peptidyl-threonine dephosphorylation (GO:0035970)4.19705712
44T cell selection (GO:0045058)4.19181236
45regulation of germinal center formation (GO:0002634)4.16910011
46antigen processing and presentation of endogenous antigen (GO:0019883)4.14882160
47mitotic cell cycle arrest (GO:0071850)4.13477061
48positive T cell selection (GO:0043368)4.13164510
49JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.10307970
50interleukin-1-mediated signaling pathway (GO:0070498)4.10236795
51viral protein processing (GO:0019082)4.09391040
52alpha-beta T cell activation (GO:0046631)4.06469057
53positive regulation of defense response to virus by host (GO:0002230)4.05216038
54embryonic process involved in female pregnancy (GO:0060136)3.98542399
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91809620
56positive regulation of T cell mediated immunity (GO:0002711)3.91105566
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.90819807
58negative regulation of interleukin-10 production (GO:0032693)3.84251508
59positive regulation of T-helper 1 type immune response (GO:0002827)3.80742900
60positive regulation of isotype switching (GO:0045830)3.77399021
61regulation of T cell cytokine production (GO:0002724)3.76744375
62T cell receptor signaling pathway (GO:0050852)3.76471105
63amyloid precursor protein catabolic process (GO:0042987)3.74623621
64entrainment of circadian clock by photoperiod (GO:0043153)3.73839964
65B cell homeostasis (GO:0001782)3.72838532
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.72223151
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.72223151
68isotype switching (GO:0045190)3.72223151
69regulation of defense response to virus by host (GO:0050691)3.72000513
70Peyers patch development (GO:0048541)3.70720582
71mucosal-associated lymphoid tissue development (GO:0048537)3.70720582
72polyamine biosynthetic process (GO:0006596)3.70611770
73* tumor necrosis factor-mediated signaling pathway (GO:0033209)3.69135004
74regulation of interleukin-2 biosynthetic process (GO:0045076)3.68940221
75CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.68874839
76cytidine deamination (GO:0009972)3.67595645
77cytidine metabolic process (GO:0046087)3.67595645
78cytidine catabolic process (GO:0006216)3.67595645
79regulation of chronic inflammatory response (GO:0002676)3.65413087
80positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.63027975
81T cell costimulation (GO:0031295)3.62078525
82sleep (GO:0030431)3.60894412
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.59374360
84mast cell activation (GO:0045576)3.56233725
85lymphocyte costimulation (GO:0031294)3.56193742
86CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.51461393
87lymph node development (GO:0048535)3.51242260
88regulation of T cell mediated immunity (GO:0002709)3.49074040
89T cell differentiation (GO:0030217)3.48856321
90response to muramyl dipeptide (GO:0032495)3.48221985
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46080674
92negative regulation of B cell apoptotic process (GO:0002903)3.44087791
93positive regulation of humoral immune response (GO:0002922)3.42934570
94negative regulation of bone resorption (GO:0045779)3.42099258
95positive regulation of interleukin-2 production (GO:0032743)3.38113471
96regulation of activated T cell proliferation (GO:0046006)3.36906756
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.36666383
98leukocyte aggregation (GO:0070486)3.36200970
99very-low-density lipoprotein particle assembly (GO:0034379)3.34574663
100regulation of cell killing (GO:0031341)3.33395091
101positive regulation of cell killing (GO:0031343)3.31274003
102positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.30605501
103positive regulation of immunoglobulin mediated immune response (GO:0002891)3.30580181
104positive regulation of B cell mediated immunity (GO:0002714)3.30580181
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30498453
106myeloid dendritic cell differentiation (GO:0043011)3.30348271
107production of molecular mediator of immune response (GO:0002440)3.28171302
108mature B cell differentiation involved in immune response (GO:0002313)3.26050539
109regulation of T-helper cell differentiation (GO:0045622)3.25876661
110regulation of cholesterol homeostasis (GO:2000188)3.24101104
111positive regulation of lymphocyte mediated immunity (GO:0002708)3.23652011
112AMP metabolic process (GO:0046033)3.23516256
113positive regulation of T-helper cell differentiation (GO:0045624)3.23356230
114positive regulation of T cell differentiation (GO:0045582)3.23018982
115CD4-positive, alpha-beta T cell activation (GO:0035710)3.20699215
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.20041279
117regulation of T-helper 1 type immune response (GO:0002825)3.19314370
118mature B cell differentiation (GO:0002335)3.18383024
119positive regulation of DNA recombination (GO:0045911)3.16303874
120positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.16155432
121regulation of interleukin-17 production (GO:0032660)3.16041117
122endoderm formation (GO:0001706)3.15711325
123regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.14312741
124regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11127819
125positive regulation of natural killer cell differentiation (GO:0032825)3.09292828
126T cell activation involved in immune response (GO:0002286)3.08688159
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07631119
128antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07631119
129positive regulation of p38MAPK cascade (GO:1900745)3.07376503
130positive regulation of interleukin-12 production (GO:0032735)3.06796503
131folic acid-containing compound biosynthetic process (GO:0009396)3.06646419
132regulation of response to interferon-gamma (GO:0060330)3.06158331
133pyrimidine ribonucleoside catabolic process (GO:0046133)3.05599795
134negative regulation of T cell mediated immunity (GO:0002710)3.05255705
135myeloid dendritic cell activation (GO:0001773)3.03890401
136antigen receptor-mediated signaling pathway (GO:0050851)3.02842762
137somatic recombination of immunoglobulin gene segments (GO:0016447)2.98784135
138establishment of viral latency (GO:0019043)2.98041132
139protein-cofactor linkage (GO:0018065)2.96716915
140T cell lineage commitment (GO:0002360)2.95878266
141T-helper 1 type immune response (GO:0042088)2.95572115
142dendritic cell chemotaxis (GO:0002407)2.95090165
143negative regulation of meiotic cell cycle (GO:0051447)2.90557336
144regulation of T cell chemotaxis (GO:0010819)2.87380453
145positive regulation of T cell chemotaxis (GO:0010820)2.87380453
146positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.86723155
147positive regulation of adaptive immune response (GO:0002821)2.85626469
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.84025649
149B cell proliferation (GO:0042100)2.82202802
150regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81193820
151regulation of natural killer cell mediated immunity (GO:0002715)2.81193820
152negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.80363157
153somatic hypermutation of immunoglobulin genes (GO:0016446)2.79749510
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79749510
155cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.78978073
156DNA strand renaturation (GO:0000733)2.77093191
157nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.76496475
158Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75581906
159positive regulation of leukocyte mediated immunity (GO:0002705)2.75306768
160negative regulation of innate immune response (GO:0045824)2.74998118
161regulation of lymphocyte mediated immunity (GO:0002706)2.73917057
162T cell proliferation (GO:0042098)2.73771597
163* positive regulation of osteoclast differentiation (GO:0045672)2.68460069
164somatic diversification of immunoglobulins (GO:0016445)2.68414333
165germ cell migration (GO:0008354)2.66896183
166positive regulation of interferon-gamma production (GO:0032729)2.66647147
167B cell mediated immunity (GO:0019724)2.65261072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.87469514
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.88699773
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse5.01345478
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.33043800
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.27600647
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.08209789
7MYC_22102868_ChIP-Seq_BL_Human4.05069486
8RUNX_20019798_ChIP-Seq_JUKART_Human3.45476415
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.39525933
10MYB_26560356_Chip-Seq_TH2_Human3.19236497
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.15475157
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.13861731
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.13321279
14FLI1_27457419_Chip-Seq_LIVER_Mouse3.06058113
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83287921
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.71734602
17MAF_26560356_Chip-Seq_TH1_Human2.71065108
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70573465
19E2F7_22180533_ChIP-Seq_HELA_Human2.59637784
20MYB_26560356_Chip-Seq_TH1_Human2.59365324
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58016678
22TCF7_22412390_ChIP-Seq_EML_Mouse2.55486788
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48646821
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45064299
25CLOCK_20551151_ChIP-Seq_293T_Human2.43648093
26SCL_19346495_ChIP-Seq_HPC-7_Human2.37849209
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35869771
28VDR_21846776_ChIP-Seq_THP-1_Human2.23723509
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23218863
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18784921
31UTX_26944678_Chip-Seq_JUKART_Human2.14911576
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11335432
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.09852679
34KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02888347
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02186292
36IRF8_22096565_ChIP-ChIP_GC-B_Human2.00893916
37KDM2B_26808549_Chip-Seq_DND41_Human2.00119854
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.95128514
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91594861
40MAF_26560356_Chip-Seq_TH2_Human1.86052874
41VDR_24763502_ChIP-Seq_THP-1_Human1.85120125
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84687291
43IRF1_19129219_ChIP-ChIP_H3396_Human1.83833851
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81080348
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77839896
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.75398769
47GATA3_27048872_Chip-Seq_THYMUS_Human1.71411335
48MYC_18940864_ChIP-ChIP_HL60_Human1.69421693
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68794789
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67003147
51FOXP3_21729870_ChIP-Seq_TREG_Human1.66819612
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64910539
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62942919
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.62232654
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60899217
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56569242
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54023473
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49932454
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49588285
60EGR1_19032775_ChIP-ChIP_M12_Human1.47726826
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46930351
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46879677
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41315752
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.41129245
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38502317
66GATA1_22025678_ChIP-Seq_K562_Human1.35801289
67* IRF8_27001747_Chip-Seq_BMDM_Mouse1.34699219
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32420277
69ELK1_19687146_ChIP-ChIP_HELA_Human1.31477303
70CIITA_25753668_ChIP-Seq_RAJI_Human1.30449431
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26303110
72FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25381833
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.25325522
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25200252
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.23613576
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21808328
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.21612652
78VDR_24787735_ChIP-Seq_THP-1_Human1.20830873
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20185760
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19886296
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.18988110
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15531700
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.13055328
84ATF3_27146783_Chip-Seq_COLON_Human1.12200549
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11921269
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11648606
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.11375850
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11158098
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09495389
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08038300
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07851544
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07764409
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07278182
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07228499
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05806271
96ZNF263_19887448_ChIP-Seq_K562_Human1.04763556
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04480820
98PU_27001747_Chip-Seq_BMDM_Mouse1.02411237
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02254798
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00787948
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00714885
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98594678
103UBF1/2_26484160_Chip-Seq_HMECs_Human0.97410309
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96760042
105SMRT_27268052_Chip-Seq_Bcells_Human0.95499024
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.95019027
107GATA3_26560356_Chip-Seq_TH1_Human0.94402687
108NCOR1_26117541_ChIP-Seq_K562_Human0.93723734
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.91405610
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87819981
111SPI1_23547873_ChIP-Seq_NB4_Human0.87498745
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87361508
113IGF1R_20145208_ChIP-Seq_DFB_Human0.86176657
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86169420
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85553732
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85493832
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85444968
118* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85296863
119GATA3_26560356_Chip-Seq_TH2_Human0.84283335
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82646141
121MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82453142
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81907111
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.81818738
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.81666615
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81666615
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81099119
127SPI1_23127762_ChIP-Seq_K562_Human0.81024889
128GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80899309
129RACK7_27058665_Chip-Seq_MCF-7_Human0.80377353
130SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79270425
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78945458
132STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78869442
133TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78660254
134HOXB7_26014856_ChIP-Seq_BT474_Human0.77054817
135VDR_23849224_ChIP-Seq_CD4+_Human0.76916682
136KDM2B_26808549_Chip-Seq_K562_Human0.76437603
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76281291
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76225367
139* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76138363
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76071177
141P300_27268052_Chip-Seq_Bcells_Human0.75299854
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.74988428
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74986222
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74984529
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74974284
146ETS1_20019798_ChIP-Seq_JURKAT_Human0.74820232
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74546928
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74421436
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74398893
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73760324
151HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73712989
152GATA2_19941826_ChIP-Seq_K562_Human0.72908573
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72862469
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.72835599
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71662276
156GATA1_19941826_ChIP-Seq_K562_Human0.71011623
157* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70784194
158GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69559618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.09365988
2MP0005671_abnormal_response_to3.95341057
3MP0003300_gastrointestinal_ulcer3.62174828
4MP0002405_respiratory_system_inflammati3.14449909
5MP0004510_myositis3.13990211
6MP0001800_abnormal_humoral_immune3.12894361
7MP0002254_reproductive_system_inflammat3.09799666
8MP0003303_peritoneal_inflammation3.06920334
9* MP0001790_abnormal_immune_system3.02047298
10* MP0005387_immune_system_phenotype3.02047298
11MP0005000_abnormal_immune_tolerance2.94865318
12* MP0000685_abnormal_immune_system2.89128270
13MP0003436_decreased_susceptibility_to2.74088784
14MP0001835_abnormal_antigen_presentation2.69941624
15MP0003866_abnormal_defecation2.68005158
16MP0003724_increased_susceptibility_to2.67056300
17MP0003195_calcinosis2.58626668
18* MP0002723_abnormal_immune_serum2.56553981
19MP0010155_abnormal_intestine_physiology2.48380373
20MP0009785_altered_susceptibility_to2.46972048
21MP0002933_joint_inflammation2.42125997
22MP0002452_abnormal_antigen_presenting2.36401588
23MP0000465_gastrointestinal_hemorrhage2.35748187
24MP0002420_abnormal_adaptive_immunity2.33999958
25MP0001853_heart_inflammation2.30691542
26MP0001819_abnormal_immune_cell2.29236661
27* MP0002398_abnormal_bone_marrow2.26644857
28MP0004947_skin_inflammation2.26417874
29MP0009333_abnormal_splenocyte_physiolog2.25813650
30MP0002876_abnormal_thyroid_physiology2.21353447
31* MP0000703_abnormal_thymus_morphology2.16365999
32MP0002166_altered_tumor_susceptibility2.11540386
33MP0005076_abnormal_cell_differentiation2.09870511
34MP0002277_abnormal_respiratory_mucosa2.05994967
35MP0001873_stomach_inflammation2.01073073
36* MP0000716_abnormal_immune_system1.98670042
37* MP0002722_abnormal_immune_system1.85781607
38MP0008961_abnormal_basal_metabolism1.85737473
39* MP0000689_abnormal_spleen_morphology1.83653303
40MP0002138_abnormal_hepatobiliary_system1.83399254
41MP0004147_increased_porphyrin_level1.82331145
42MP0001845_abnormal_inflammatory_respons1.72750585
43MP0005025_abnormal_response_to1.72559613
44MP0004808_abnormal_hematopoietic_stem1.67116924
45MP0001502_abnormal_circadian_rhythm1.63240522
46MP0002419_abnormal_innate_immunity1.61852253
47MP0000604_amyloidosis1.60593473
48MP0002998_abnormal_bone_remodeling1.59481602
49MP0009840_abnormal_foam_cell1.59433741
50MP0005645_abnormal_hypothalamus_physiol1.59325768
51* MP0002429_abnormal_blood_cell1.58445914
52MP0010094_abnormal_chromosome_stability1.54474368
53MP0001533_abnormal_skeleton_physiology1.53535924
54MP0002006_tumorigenesis1.52867921
55MP0002877_abnormal_melanocyte_morpholog1.51296345
56MP0005377_hearing/vestibular/ear_phenot1.47782200
57MP0003878_abnormal_ear_physiology1.47782200
58MP0002148_abnormal_hypersensitivity_rea1.39231846
59MP0008875_abnormal_xenobiotic_pharmacok1.39161731
60MP0001851_eye_inflammation1.35981438
61MP0006082_CNS_inflammation1.33227958
62MP0010352_gastrointestinal_tract_polyps1.31549634
63MP0002396_abnormal_hematopoietic_system1.31524217
64MP0004782_abnormal_surfactant_physiolog1.31016883
65MP0002163_abnormal_gland_morphology1.24400190
66MP0008872_abnormal_physiological_respon1.22533261
67MP0000490_abnormal_crypts_of1.20292678
68MP0008007_abnormal_cellular_replicative1.18950327
69MP0008877_abnormal_DNA_methylation1.14084976
70MP0001501_abnormal_sleep_pattern1.12656001
71MP0005397_hematopoietic_system_phenotyp1.12035590
72MP0001545_abnormal_hematopoietic_system1.12035590
73MP0003011_delayed_dark_adaptation1.11824161
74MP0001919_abnormal_reproductive_system1.11010228
75* MP0001881_abnormal_mammary_gland1.10016279
76MP0005075_abnormal_melanosome_morpholog1.08817149
77MP0005084_abnormal_gallbladder_morpholo1.08485373
78MP0003693_abnormal_embryo_hatching1.07668198
79MP0000249_abnormal_blood_vessel1.07329745
80MP0000858_altered_metastatic_potential1.05723496
81MP0008004_abnormal_stomach_pH1.02680305
82MP0006072_abnormal_retinal_apoptosis1.02174494
83MP0008057_abnormal_DNA_replication0.99692521
84MP0000609_abnormal_liver_physiology0.99533452
85MP0003448_altered_tumor_morphology0.95766737
86MP0004957_abnormal_blastocyst_morpholog0.95220082
87MP0001727_abnormal_embryo_implantation0.94870067
88MP0002102_abnormal_ear_morphology0.94290655
89MP0004264_abnormal_extraembryonic_tissu0.90942216
90* MP0003795_abnormal_bone_structure0.89650030
91MP0009384_cardiac_valve_regurgitation0.89039829
92MP0003091_abnormal_cell_migration0.88911140
93MP0003453_abnormal_keratinocyte_physiol0.88675107
94MP0004885_abnormal_endolymph0.88669033
95MP0005379_endocrine/exocrine_gland_phen0.88066245
96MP0005023_abnormal_wound_healing0.87545773
97MP0009278_abnormal_bone_marrow0.87210123
98MP0005390_skeleton_phenotype0.86579934
99MP0003828_pulmonary_edema0.85915218
100MP0004145_abnormal_muscle_electrophysio0.85806709
101MP0003111_abnormal_nucleus_morphology0.85060343
102MP0001661_extended_life_span0.84950634
103MP0001243_abnormal_dermal_layer0.82786411
104MP0000343_altered_response_to0.80177717
105MP0003252_abnormal_bile_duct0.80126813
106MP0001348_abnormal_lacrimal_gland0.79663568
107MP0003183_abnormal_peptide_metabolism0.78781969
108MP0008469_abnormal_protein_level0.78679996
109MP0005464_abnormal_platelet_physiology0.78295919
110MP0003638_abnormal_response/metabolism_0.77165894
111MP0001216_abnormal_epidermal_layer0.77004030
112MP0002060_abnormal_skin_morphology0.76060015
113MP0003718_maternal_effect0.73835544
114MP0009765_abnormal_xenobiotic_induced0.72703968
115MP0001765_abnormal_ion_homeostasis0.72468844
116MP0008058_abnormal_DNA_repair0.72116131
117MP0002019_abnormal_tumor_incidence0.70149175
118MP0001542_abnormal_bone_strength0.69039093
119MP0005085_abnormal_gallbladder_physiolo0.68534429
120MP0000477_abnormal_intestine_morphology0.66833967
121MP0003191_abnormal_cellular_cholesterol0.65546344
122MP0000350_abnormal_cell_proliferation0.64798699
123MP0000733_abnormal_muscle_development0.64615538
124MP0005389_reproductive_system_phenotype0.63151458
125MP0003705_abnormal_hypodermis_morpholog0.59782730
126MP0009764_decreased_sensitivity_to0.59367071
127MP0005310_abnormal_salivary_gland0.59026411
128MP0002136_abnormal_kidney_physiology0.56977062
129MP0001663_abnormal_digestive_system0.56314102
130MP0000427_abnormal_hair_cycle0.56070770
131MP0002009_preneoplasia0.55932655
132MP0002928_abnormal_bile_duct0.55816542
133MP0000367_abnormal_coat/_hair0.55571946
134MP0005332_abnormal_amino_acid0.55309378
135MP0004742_abnormal_vestibular_system0.55139950
136MP0005365_abnormal_bile_salt0.55012088
137MP0001191_abnormal_skin_condition0.54796948
138MP0009763_increased_sensitivity_to0.54084013
139MP0003077_abnormal_cell_cycle0.53698746
140MP0010307_abnormal_tumor_latency0.52667122
141MP0003566_abnormal_cell_adhesion0.51231894
142MP0005165_increased_susceptibility_to0.49844457
143MP0010329_abnormal_lipoprotein_level0.49665784
144MP0000538_abnormal_urinary_bladder0.47757483

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)8.16266573
2Optic neuritis (HP:0100653)8.16266573
3Orchitis (HP:0100796)7.20840398
4Stomatitis (HP:0010280)6.94969653
5Myositis (HP:0100614)6.82717766
6Keratoconjunctivitis sicca (HP:0001097)5.86014624
7Keratoconjunctivitis (HP:0001096)5.28884000
8T lymphocytopenia (HP:0005403)5.14507439
9Arterial thrombosis (HP:0004420)4.92258303
10Elevated erythrocyte sedimentation rate (HP:0003565)4.91277393
11Abnormality of T cell number (HP:0011839)4.90874897
12Severe combined immunodeficiency (HP:0004430)4.87841054
13IgM deficiency (HP:0002850)4.84653213
14Agammaglobulinemia (HP:0004432)4.64967965
15Pulmonary infiltrates (HP:0002113)4.64657252
16IgA deficiency (HP:0002720)4.39280266
17Combined immunodeficiency (HP:0005387)4.17044887
18Hypophosphatemic rickets (HP:0004912)4.12490947
19Abnormality of T cells (HP:0002843)4.03029481
20IgG deficiency (HP:0004315)3.86570186
21Thyroiditis (HP:0100646)3.86284919
22Papilledema (HP:0001085)3.68289722
23Gastrointestinal infarctions (HP:0005244)3.61044032
24Hemoptysis (HP:0002105)3.55427556
25Recurrent fungal infections (HP:0002841)3.54631240
26Vasculitis (HP:0002633)3.41110409
27Abnormality of the prostate (HP:0008775)3.39451269
28Eczematoid dermatitis (HP:0000976)3.37140625
29Pulmonary embolism (HP:0002204)3.18926263
30Abnormality of eosinophils (HP:0001879)3.16584981
31Bronchitis (HP:0012387)3.14710613
32Joint swelling (HP:0001386)3.11040773
33Recurrent bronchitis (HP:0002837)3.09434580
34Gangrene (HP:0100758)3.08218438
35Abnormality of T cell physiology (HP:0011840)3.04124625
36Recurrent sinusitis (HP:0011108)3.04067753
37Increased IgM level (HP:0003496)3.02912198
38Abnormality of B cell number (HP:0010975)3.00773346
39B lymphocytopenia (HP:0010976)3.00773346
40Panhypogammaglobulinemia (HP:0003139)2.98755811
41Prostate neoplasm (HP:0100787)2.94476033
42Chronic diarrhea (HP:0002028)2.92430393
43Gastrointestinal stroma tumor (HP:0100723)2.89574771
44Anorexia (HP:0002039)2.87588986
45Encephalitis (HP:0002383)2.80137013
46Increased hepatocellular lipid droplets (HP:0006565)2.76933002
47Abnormality of the fingertips (HP:0001211)2.74405018
48Peritonitis (HP:0002586)2.72816042
49Thrombocytosis (HP:0001894)2.68697881
50Thrombophlebitis (HP:0004418)2.67038971
51Lipid accumulation in hepatocytes (HP:0006561)2.63023136
52Leukocytosis (HP:0001974)2.61979052
53Conical tooth (HP:0000698)2.60701380
54Keratitis (HP:0000491)2.57647582
55Brittle hair (HP:0002299)2.54673537
56Facial diplegia (HP:0001349)2.54304746
57Abnormality of the labia minora (HP:0012880)2.53586037
58Colon cancer (HP:0003003)2.52421956
59Recurrent viral infections (HP:0004429)2.51294481
60Hypoplasia of the thymus (HP:0000778)2.46515240
61Nasal polyposis (HP:0100582)2.45035459
62Fatigue (HP:0012378)2.43505422
63Papilloma (HP:0012740)2.42770650
64Verrucae (HP:0200043)2.42770650
65Stomach cancer (HP:0012126)2.40765570
66Arthralgia (HP:0002829)2.38859462
67* Premature loss of primary teeth (HP:0006323)2.35026900
68Abnormality of male internal genitalia (HP:0000022)2.33785993
69Carpal bone hypoplasia (HP:0001498)2.33215829
70Glomerulopathy (HP:0100820)2.32667461
71Aortic aneurysm (HP:0004942)2.30531357
72Recurrent cutaneous fungal infections (HP:0011370)2.28364282
73Chronic mucocutaneous candidiasis (HP:0002728)2.28364282
74Interstitial pulmonary disease (HP:0006530)2.27479016
75Meningitis (HP:0001287)2.26928053
76Lymphoma (HP:0002665)2.25454682
77Ureteral duplication (HP:0000073)2.25095647
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.22182787
79Chronic hepatic failure (HP:0100626)2.22129010
80Renal cortical cysts (HP:0000803)2.21525000
81Aortic dissection (HP:0002647)2.21060354
82Abnormality of the pleura (HP:0002103)2.21057115
83Chest pain (HP:0100749)2.20058310
84Abnormal albumin level (HP:0012116)2.18139632
85Hypoalbuminemia (HP:0003073)2.18139632
86Metaphyseal dysplasia (HP:0100255)2.17790270
87Restrictive lung disease (HP:0002091)2.17669988
88Abnormality of the peritoneum (HP:0002585)2.17475768
89Abnormality of the pericardium (HP:0001697)2.16475917
90Abnormality of the endocardium (HP:0004306)2.16378219
91Somatic mutation (HP:0001428)2.16343775
92Abnormality of the renal cortex (HP:0011035)2.15704442
93Myocardial infarction (HP:0001658)2.14679772
94Aseptic necrosis (HP:0010885)2.14644609
95Acrocyanosis (HP:0001063)2.13222981
96Amaurosis fugax (HP:0100576)2.10582538
97Abnormality of the nasal mucosa (HP:0000433)2.08311344
98Small epiphyses (HP:0010585)2.07798667
99Acute myeloid leukemia (HP:0004808)2.06755581
100Renal Fanconi syndrome (HP:0001994)2.05858054
101Abnormality of dental color (HP:0011073)2.05677246
102Mediastinal lymphadenopathy (HP:0100721)2.04122367
103Lymphopenia (HP:0001888)2.03558518
104Increased IgE level (HP:0003212)2.02107223
105Protrusio acetabuli (HP:0003179)2.02014631
106Abnormal pancreas size (HP:0012094)2.01095519
107Striae distensae (HP:0001065)2.00042757
108Eosinophilia (HP:0001880)1.99243823
109Neutropenia (HP:0001875)1.98437988
110Abnormality of cells of the lymphoid lineage (HP:0012140)1.96283337
111Rickets (HP:0002748)1.95943067
112* Persistence of primary teeth (HP:0006335)1.95623373
113Hypergammaglobulinemia (HP:0010702)1.95513254
114Metabolic alkalosis (HP:0200114)1.95295341
115Abnormality of the nasal septum (HP:0000419)1.93962565
116Inflammation of the large intestine (HP:0002037)1.93212277
117Camptodactyly of toe (HP:0001836)1.92892695
118Abnormality of DNA repair (HP:0003254)1.91686042
119Vertigo (HP:0002321)1.90796154
120Pustule (HP:0200039)1.90611217
121Emphysema (HP:0002097)1.88879704
122Skin rash (HP:0000988)1.88486902
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87738689
124* Increased density of long bones (HP:0006392)1.87084461
125Anhidrosis (HP:0000970)1.86497241
126Granulocytopenia (HP:0001913)1.85055607
127Clubbing of toes (HP:0100760)1.83327156
128Gastrointestinal inflammation (HP:0004386)1.83006168
129Dysostosis multiplex (HP:0000943)1.82941023
130Polyneuropathy (HP:0001271)1.82218243
131Increased intramyocellular lipid droplets (HP:0012240)1.81902710
132Mucopolysacchariduria (HP:0008155)1.81550993
133Urinary glycosaminoglycan excretion (HP:0003541)1.81550993
134Abolished electroretinogram (ERG) (HP:0000550)1.80740931
135Gingival bleeding (HP:0000225)1.80559295
136Dislocated radial head (HP:0003083)1.80120483
137Abnormality of homocysteine metabolism (HP:0010919)1.79970163
138Homocystinuria (HP:0002156)1.79970163
139Mitral valve prolapse (HP:0001634)1.77981593
140Pulmonary fibrosis (HP:0002206)1.77876152
141Abnormality of the alveolar ridges (HP:0006477)1.77316856
142Polycythemia (HP:0001901)1.76679574
143Abnormality of the vertebral endplates (HP:0005106)1.76104859
144Dilatation of the ascending aorta (HP:0005111)1.75830637
145Unilateral renal agenesis (HP:0000122)1.75235959
146Cerebral ischemia (HP:0002637)1.73479461
147Spontaneous hematomas (HP:0007420)1.70591315
148Chronic otitis media (HP:0000389)1.70205650
149Paresthesia (HP:0003401)1.68258450
150Broad palm (HP:0001169)1.66497760
151Abnormality of the radial head (HP:0003995)1.66089521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.04892780
2TAOK35.65833765
3MAP4K14.44792283
4IRAK34.34526043
5MAP2K24.22121515
6MAP3K143.18935067
7VRK22.94874506
8JAK32.87896844
9EEF2K2.84212314
10EIF2AK32.78678075
11TLK12.77918964
12ITK2.70658046
13TAF12.62939689
14TSSK62.54865643
15TEC2.46747134
16ZAP702.41337207
17TESK22.37679860
18NUAK12.30535377
19BMPR22.17597018
20JAK12.12139656
21ZAK2.05541649
22IKBKB2.03200009
23SMG12.01181065
24CHUK1.99372803
25MST41.90178858
26CDC42BPA1.88566645
27EIF2AK21.82288881
28MAPK151.78359623
29NEK91.73993908
30BTK1.73505048
31FGFR41.66151628
32VRK11.65777760
33TBK11.61413873
34CDK121.60738238
35IKBKE1.58045259
36PIM11.56480270
37EPHB11.54496872
38MUSK1.52358986
39EPHA31.51652579
40GRK61.51170900
41FGFR31.46921700
42BCKDK1.45622402
43RIPK41.37626681
44HCK1.29385891
45TYK21.25321744
46STK101.20469243
47LCK1.19707690
48CDC71.19216499
49RPS6KA41.17676947
50NME11.15595220
51PRPF4B1.15041761
52MAP3K71.14037981
53SYK1.10182578
54NLK1.06121309
55KDR1.04683464
56ACVR1B1.01800022
57TNIK0.97355882
58GSK3A0.93002463
59TAOK10.92973924
60MAP2K30.89772705
61TRIB30.88004268
62KIT0.87758175
63PKN20.86247077
64PIM20.85052337
65BMX0.84512355
66CSF1R0.83759749
67BCR0.82366259
68MAPK70.81588642
69JAK20.78341075
70ADRBK20.77752625
71PDGFRB0.75924342
72ALK0.75113797
73GRK10.74001643
74MAP2K10.73752971
75PRKCQ0.73558496
76MAP3K100.72110654
77RPS6KA50.71862208
78CDK60.71130024
79CDK40.70573836
80MAP4K20.69677269
81PLK30.68458050
82MKNK10.67865242
83RPS6KA10.67453313
84OXSR10.66955835
85STK240.65337639
86MELK0.64217006
87MAP3K110.63019815
88SIK20.62199040
89CDK90.62141145
90RPS6KB10.60948954
91PRKCH0.60935328
92TTK0.60841542
93FGR0.59774506
94CSK0.58949772
95MAPKAPK50.58011405
96PDK20.55945768
97LRRK20.55216214
98NEK10.54425714
99MKNK20.54423503
100STK40.54069128
101BUB10.53164931
102CDK190.51970682
103PTK60.49879225
104HIPK20.48323524
105LYN0.48092850
106BRD40.48044461
107STK38L0.45899288
108RET0.43374838
109SIK10.43244373
110PRKCD0.42731410
111MAP3K30.42338362
112SIK30.41393473
113TAOK20.40972127
114MAPKAPK20.40899655
115TGFBR10.38099374
116TGFBR20.37986249
117STK30.37318102
118RPS6KB20.37010823
119FRK0.35367122
120ATR0.35362146
121PAK20.35164212
122IGF1R0.35109695
123INSR0.34889862
124FES0.34300441
125MAP3K80.34064834
126STK390.33419103
127MARK30.32885300
128GRK50.31461480
129MAP3K130.31291752
130PDK10.30526558
131PRKCI0.29267680
132MATK0.29237888
133ABL10.28987413
134FGFR10.27314422
135EGFR0.26584653
136DMPK0.26233304
137TNK20.25889706
138PASK0.25599739
139MAPK10.25599435
140MAPK40.24367886
141STK110.24364406
142MAPKAPK30.24167836
143PLK40.23608724
144GRK70.23449765
145MAPK80.22681035
146MAPK30.22669416
147MAP3K50.22234688
148MTOR0.20269252
149LIMK10.20223005
150CAMK2G0.20205950
151AURKA0.19858115
152WNK40.19837343
153MAPK90.19359772
154RAF10.19359289
155MARK20.18859731
156TRPM70.18372956

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004007.74380791
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053215.58574030
3T cell receptor signaling pathway_Homo sapiens_hsa046603.56842292
4Primary immunodeficiency_Homo sapiens_hsa053403.51581988
5* NF-kappa B signaling pathway_Homo sapiens_hsa040643.07252891
6Allograft rejection_Homo sapiens_hsa053302.79173766
7* Osteoclast differentiation_Homo sapiens_hsa043802.66501960
8Circadian rhythm_Homo sapiens_hsa047102.57951794
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.50999769
10Measles_Homo sapiens_hsa051622.47483355
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.31473563
12TNF signaling pathway_Homo sapiens_hsa046682.22129053
13Leishmaniasis_Homo sapiens_hsa051401.95685215
14Autoimmune thyroid disease_Homo sapiens_hsa053201.95341581
15Asthma_Homo sapiens_hsa053101.91680112
16B cell receptor signaling pathway_Homo sapiens_hsa046621.87306459
17Antigen processing and presentation_Homo sapiens_hsa046121.76205510
18* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75566296
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71552209
20Toxoplasmosis_Homo sapiens_hsa051451.70723666
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69456790
22Phenylalanine metabolism_Homo sapiens_hsa003601.64576670
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62238072
24Mismatch repair_Homo sapiens_hsa034301.62196587
25Caffeine metabolism_Homo sapiens_hsa002321.59672348
26Graft-versus-host disease_Homo sapiens_hsa053321.59388993
27Acute myeloid leukemia_Homo sapiens_hsa052211.55979797
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.53858716
29Legionellosis_Homo sapiens_hsa051341.51834173
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51595290
31Type I diabetes mellitus_Homo sapiens_hsa049401.48261141
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44811156
33Hematopoietic cell lineage_Homo sapiens_hsa046401.44405773
34Proteasome_Homo sapiens_hsa030501.36628125
35Hepatitis B_Homo sapiens_hsa051611.36487920
36Chronic myeloid leukemia_Homo sapiens_hsa052201.35585975
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35566943
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.34309245
39HTLV-I infection_Homo sapiens_hsa051661.34279378
40Fanconi anemia pathway_Homo sapiens_hsa034601.29118731
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28926980
42Herpes simplex infection_Homo sapiens_hsa051681.28685958
43Systemic lupus erythematosus_Homo sapiens_hsa053221.28034813
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27241836
45Tryptophan metabolism_Homo sapiens_hsa003801.25537467
46* Prolactin signaling pathway_Homo sapiens_hsa049171.20596600
47Apoptosis_Homo sapiens_hsa042101.16892711
48Chemokine signaling pathway_Homo sapiens_hsa040621.15567085
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.13439739
50Epstein-Barr virus infection_Homo sapiens_hsa051691.12589805
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.11106686
52Vitamin digestion and absorption_Homo sapiens_hsa049771.09630182
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09331368
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09182049
55Pancreatic cancer_Homo sapiens_hsa052121.06583607
56Non-homologous end-joining_Homo sapiens_hsa034501.06533289
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.06387623
58Influenza A_Homo sapiens_hsa051641.05983163
59Shigellosis_Homo sapiens_hsa051311.03913014
60Viral myocarditis_Homo sapiens_hsa054161.03044183
61DNA replication_Homo sapiens_hsa030301.00228068
62Viral carcinogenesis_Homo sapiens_hsa052030.97884809
63Homologous recombination_Homo sapiens_hsa034400.97670544
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93120930
65MAPK signaling pathway_Homo sapiens_hsa040100.92315987
66VEGF signaling pathway_Homo sapiens_hsa043700.88719146
67Protein export_Homo sapiens_hsa030600.85542286
68Small cell lung cancer_Homo sapiens_hsa052220.85458329
69Base excision repair_Homo sapiens_hsa034100.85411255
70Nucleotide excision repair_Homo sapiens_hsa034200.84538983
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83155931
72p53 signaling pathway_Homo sapiens_hsa041150.83077444
73HIF-1 signaling pathway_Homo sapiens_hsa040660.80245153
74Steroid biosynthesis_Homo sapiens_hsa001000.79480061
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79165484
76MicroRNAs in cancer_Homo sapiens_hsa052060.78578477
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.76372495
78Phototransduction_Homo sapiens_hsa047440.74474943
79Malaria_Homo sapiens_hsa051440.73329915
80RNA polymerase_Homo sapiens_hsa030200.72958620
81Colorectal cancer_Homo sapiens_hsa052100.72575024
82Basal transcription factors_Homo sapiens_hsa030220.69569619
83Type II diabetes mellitus_Homo sapiens_hsa049300.69470950
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67715881
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67204913
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64868522
87Platelet activation_Homo sapiens_hsa046110.62156682
88Insulin resistance_Homo sapiens_hsa049310.62103760
89Salmonella infection_Homo sapiens_hsa051320.61238448
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59923105
91Selenocompound metabolism_Homo sapiens_hsa004500.59209659
92Renal cell carcinoma_Homo sapiens_hsa052110.58669584
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56602429
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.55956102
95Tuberculosis_Homo sapiens_hsa051520.55506044
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55458483
97Hepatitis C_Homo sapiens_hsa051600.54111929
98FoxO signaling pathway_Homo sapiens_hsa040680.53993721
99Endocytosis_Homo sapiens_hsa041440.53025974
100Tyrosine metabolism_Homo sapiens_hsa003500.52104470
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51768066
102Purine metabolism_Homo sapiens_hsa002300.50232920
103Prostate cancer_Homo sapiens_hsa052150.49957536
104Cocaine addiction_Homo sapiens_hsa050300.49523506
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.48480995
106Propanoate metabolism_Homo sapiens_hsa006400.47579602
107Arginine and proline metabolism_Homo sapiens_hsa003300.46714298
108Spliceosome_Homo sapiens_hsa030400.46673693
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42904176
110mTOR signaling pathway_Homo sapiens_hsa041500.39830219
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39798618
112Fat digestion and absorption_Homo sapiens_hsa049750.39671762
113Pertussis_Homo sapiens_hsa051330.38846172
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38429058
115Pathways in cancer_Homo sapiens_hsa052000.37401033
116Staphylococcus aureus infection_Homo sapiens_hsa051500.37256176
117RNA transport_Homo sapiens_hsa030130.36543996
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36152801
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36132883
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35479590
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35326439
122Fatty acid elongation_Homo sapiens_hsa000620.33850922
123Proteoglycans in cancer_Homo sapiens_hsa052050.32825156
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31875928
125Pyrimidine metabolism_Homo sapiens_hsa002400.31517869
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31194566
127ErbB signaling pathway_Homo sapiens_hsa040120.30582517
128ABC transporters_Homo sapiens_hsa020100.30507914
129Non-small cell lung cancer_Homo sapiens_hsa052230.30002736
130* Rheumatoid arthritis_Homo sapiens_hsa053230.29663970
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29034659
132Estrogen signaling pathway_Homo sapiens_hsa049150.28848404
133Ovarian steroidogenesis_Homo sapiens_hsa049130.27933673
134Peroxisome_Homo sapiens_hsa041460.27594940
135Focal adhesion_Homo sapiens_hsa045100.27259755
136Renin-angiotensin system_Homo sapiens_hsa046140.26759322
137Notch signaling pathway_Homo sapiens_hsa043300.26665889
138Retinol metabolism_Homo sapiens_hsa008300.25522805
139RNA degradation_Homo sapiens_hsa030180.24897393
140Amoebiasis_Homo sapiens_hsa051460.23453813
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23218462
142Biosynthesis of amino acids_Homo sapiens_hsa012300.22574171
143Lysine degradation_Homo sapiens_hsa003100.21874237
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.21209025
145Arachidonic acid metabolism_Homo sapiens_hsa005900.20767812
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20233804
147Thyroid cancer_Homo sapiens_hsa052160.20090559
148One carbon pool by folate_Homo sapiens_hsa006700.20041786
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18873824
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17538348
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15813997
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14114755
153Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13342570

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »