TNFSF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.50606659
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.50606659
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.50606659
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.50606659
5modulation by symbiont of host immune response (GO:0052553)5.50606659
6positive regulation by symbiont of host defense response (GO:0052509)5.50606659
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.25825398
8negative regulation of cell killing (GO:0031342)5.25825398
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49107659
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46518711
11antigen processing and presentation of endogenous antigen (GO:0019883)4.35335663
12regulation of interferon-beta biosynthetic process (GO:0045357)4.32809949
13positive regulation of gamma-delta T cell activation (GO:0046645)4.30420251
14regulation of mononuclear cell migration (GO:0071675)4.15737728
15regulation of rhodopsin mediated signaling pathway (GO:0022400)4.12858670
16rhodopsin mediated signaling pathway (GO:0016056)4.01457959
17macrophage activation involved in immune response (GO:0002281)3.96597623
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96356622
19apoptotic cell clearance (GO:0043277)3.90474823
20detection of other organism (GO:0098543)3.88441032
21detection of bacterium (GO:0016045)3.79831151
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70739939
23neutrophil activation involved in immune response (GO:0002283)3.69718235
24negative regulation of interleukin-12 production (GO:0032695)3.63170550
25retinal cone cell development (GO:0046549)3.62069082
26negative regulation of erythrocyte differentiation (GO:0045647)3.61123255
27regulation of B cell receptor signaling pathway (GO:0050855)3.57822340
28mannose metabolic process (GO:0006013)3.56214169
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51248693
30response to host immune response (GO:0052572)3.51248693
31low-density lipoprotein particle clearance (GO:0034383)3.47883600
32regulation of cholesterol storage (GO:0010885)3.46492530
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.45975362
34positive regulation of interferon-alpha production (GO:0032727)3.43802527
35detection of external biotic stimulus (GO:0098581)3.43699543
36regulation of interferon-alpha production (GO:0032647)3.24666462
37regulation of gamma-delta T cell activation (GO:0046643)3.23762543
38negative regulation of mast cell activation (GO:0033004)3.21662919
39response to host (GO:0075136)3.19454385
40response to host defenses (GO:0052200)3.19454385
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19454385
42detection of molecule of bacterial origin (GO:0032490)3.18249828
43leukocyte aggregation (GO:0070486)3.17109172
44regulation of integrin activation (GO:0033623)3.16660392
45positive regulation of guanylate cyclase activity (GO:0031284)3.10578727
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.10124992
47negative regulation of leukocyte mediated immunity (GO:0002704)3.05566254
48regulation of T-helper 2 cell differentiation (GO:0045628)3.02634694
49respiratory burst (GO:0045730)3.01515519
50immunoglobulin mediated immune response (GO:0016064)2.99664233
51detection of biotic stimulus (GO:0009595)2.97282650
52regulation of T cell tolerance induction (GO:0002664)2.95619738
53regulation of macrophage chemotaxis (GO:0010758)2.94731947
54positive regulation of mast cell activation involved in immune response (GO:0033008)2.94201028
55positive regulation of mast cell degranulation (GO:0043306)2.94201028
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93771336
57phototransduction, visible light (GO:0007603)2.92307796
58microglial cell activation (GO:0001774)2.91530332
59cell adhesion mediated by integrin (GO:0033627)2.90602151
60regulation of mast cell degranulation (GO:0043304)2.90341617
61neutrophil activation (GO:0042119)2.90195494
62cellular response to thyroid hormone stimulus (GO:0097067)2.89532967
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89075438
64barbed-end actin filament capping (GO:0051016)2.88912841
65wound healing, spreading of epidermal cells (GO:0035313)2.87677425
66regulation of gamma-delta T cell differentiation (GO:0045586)2.87206894
67response to type I interferon (GO:0034340)2.86888752
68cellular extravasation (GO:0045123)2.86559994
69type I interferon signaling pathway (GO:0060337)2.85401775
70cellular response to type I interferon (GO:0071357)2.85401775
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83994994
72lipoprotein transport (GO:0042953)2.83492252
73positive regulation of p38MAPK cascade (GO:1900745)2.82372730
74phototransduction (GO:0007602)2.82315434
75regulation of guanylate cyclase activity (GO:0031282)2.82090870
76regulation of mast cell activation involved in immune response (GO:0033006)2.81565067
77macrophage activation (GO:0042116)2.81234107
78lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81203625
79interferon-gamma-mediated signaling pathway (GO:0060333)2.80848346
80keratan sulfate catabolic process (GO:0042340)2.79437808
81negative regulation of cytokine production involved in immune response (GO:0002719)2.72025868
82photoreceptor cell development (GO:0042461)2.70403509
83regulation of regulated secretory pathway (GO:1903305)2.70256589
84regulation of tolerance induction (GO:0002643)2.70088809
85germinal center formation (GO:0002467)2.69961967
86basement membrane organization (GO:0071711)2.69080002
87positive thymic T cell selection (GO:0045059)2.68671604
88positive regulation of cellular amide metabolic process (GO:0034250)2.68619580
89protein carboxylation (GO:0018214)2.66328074
90peptidyl-glutamic acid carboxylation (GO:0017187)2.66328074
91response to peptidoglycan (GO:0032494)2.65422395
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65333008
93regulation of natural killer cell mediated immunity (GO:0002715)2.65256943
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65256943
95regulation of leukocyte degranulation (GO:0043300)2.65184177
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64377936
97negative regulation of innate immune response (GO:0045824)2.64035818
98hyaluronan catabolic process (GO:0030214)2.63482543
99positive regulation of lipid storage (GO:0010884)2.62581200
100negative regulation of T cell mediated immunity (GO:0002710)2.61646004
101eye photoreceptor cell development (GO:0042462)2.61415952
102detection of visible light (GO:0009584)2.60885834
103regulation of antigen processing and presentation (GO:0002577)2.60060559
104response to interleukin-15 (GO:0070672)2.59406134
105negative regulation of lipid storage (GO:0010888)2.59275469
106lymphocyte chemotaxis (GO:0048247)2.59180016
107granulocyte activation (GO:0036230)2.58371321
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58121844
109positive regulation of phagocytosis (GO:0050766)2.57677173
110negative regulation of phagocytosis (GO:0050765)2.57384814
111plasma lipoprotein particle clearance (GO:0034381)2.56961610
112antigen processing and presentation via MHC class Ib (GO:0002475)2.56525276
113positive regulation of macrophage cytokine production (GO:0060907)2.56118762
114detection of light stimulus (GO:0009583)2.55536581
115NIK/NF-kappaB signaling (GO:0038061)2.55454159
116pinocytosis (GO:0006907)2.54476702
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54090393
118positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.53646091
119response to thyroid hormone (GO:0097066)2.53305128
120positive regulation of leukocyte degranulation (GO:0043302)2.52334504
121myeloid cell activation involved in immune response (GO:0002275)2.52002771
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51809475
123protein-chromophore linkage (GO:0018298)2.51131077
124tolerance induction (GO:0002507)2.50955300
125negative regulation of type 2 immune response (GO:0002829)2.50437026
126regulation of type 2 immune response (GO:0002828)2.49365060
127regulation of membrane protein ectodomain proteolysis (GO:0051043)2.49256982
128regulation of phagocytosis (GO:0050764)2.48513998
129defense response to protozoan (GO:0042832)2.47297356
130positive regulation of mast cell activation (GO:0033005)2.47155352
131T-helper 1 type immune response (GO:0042088)2.46559300
132hydrogen peroxide biosynthetic process (GO:0050665)2.45822797
133positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.44795971
134positive regulation of antigen processing and presentation (GO:0002579)2.44271736
135amyloid precursor protein catabolic process (GO:0042987)2.44246989
136detection of light stimulus involved in visual perception (GO:0050908)2.43892911
137detection of light stimulus involved in sensory perception (GO:0050962)2.43892911
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43766139
139regulation of interleukin-8 biosynthetic process (GO:0045414)2.43346105
140glomerular visceral epithelial cell development (GO:0072015)2.43001023
141regulation of mast cell activation (GO:0033003)2.42721365
142positive regulation of type 2 immune response (GO:0002830)2.42590366
143amino sugar catabolic process (GO:0046348)2.42481589
144regulation of T cell mediated cytotoxicity (GO:0001914)2.42032562
145fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41803958
146positive regulation of interferon-beta production (GO:0032728)2.40123732
147positive regulation of Rap GTPase activity (GO:0032854)2.39742315
148phagocytosis, recognition (GO:0006910)2.39575096
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38079069
150positive regulation of chemokine biosynthetic process (GO:0045080)2.37233069
151response to muramyl dipeptide (GO:0032495)2.36762098
152myeloid dendritic cell differentiation (GO:0043011)2.36256670
153positive regulation of coagulation (GO:0050820)2.35081693
154response to laminar fluid shear stress (GO:0034616)2.35020576
155complement activation, alternative pathway (GO:0006957)2.34852022
156negative regulation of interleukin-6 production (GO:0032715)2.34627854
157L-alpha-amino acid transmembrane transport (GO:1902475)2.34410475
158I-kappaB phosphorylation (GO:0007252)2.33805270
159regulation of macrophage cytokine production (GO:0010935)2.33078818
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30573481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.93686599
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.79768188
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.54645861
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24831782
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.12488830
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.11961659
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.11958546
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.82005865
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68165560
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.67920494
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52459938
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48831340
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40094717
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36669900
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31166506
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.26018494
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12937334
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07987952
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03284118
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03146995
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.95493679
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.88279475
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86379418
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.84323824
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83476026
26CLOCK_20551151_ChIP-Seq_293T_Human1.81323525
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78084533
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.76982628
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76089513
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67349254
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65648961
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63755215
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63245496
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63141701
35SPI1_23127762_ChIP-Seq_K562_Human1.57705952
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56265430
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55606321
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54989277
39LXR_22292898_ChIP-Seq_THP-1_Human1.54064337
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53222698
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52162494
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50093429
43UTX_26944678_Chip-Seq_JUKART_Human1.48562429
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45745326
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44859825
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44105594
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42985344
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.37167603
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36651804
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.36186509
51MAF_26560356_Chip-Seq_TH2_Human1.35550053
52MYC_22102868_ChIP-Seq_BL_Human1.31647925
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31259478
54VDR_24787735_ChIP-Seq_THP-1_Human1.29502724
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.28394827
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27964245
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.27489818
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26719835
59DROSHA_22980978_ChIP-Seq_HELA_Human1.26212993
60TCF7_22412390_ChIP-Seq_EML_Mouse1.25996673
61PU_27001747_Chip-Seq_BMDM_Mouse1.25635907
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25435130
63* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24891448
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24473055
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.24140336
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24132149
67MYB_26560356_Chip-Seq_TH2_Human1.23899817
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22781406
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22735413
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22159650
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21260573
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20987596
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20185575
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18787148
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18771777
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.18346387
77KDM2B_26808549_Chip-Seq_DND41_Human1.18014505
78VDR_24763502_ChIP-Seq_THP-1_Human1.17300828
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17172875
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.15632254
81BCL6_27268052_Chip-Seq_Bcells_Human1.14600497
82VDR_21846776_ChIP-Seq_THP-1_Human1.13429888
83CJUN_26792858_Chip-Seq_BT549_Human1.13077990
84BCOR_27268052_Chip-Seq_Bcells_Human1.12660670
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12147698
86RACK7_27058665_Chip-Seq_MCF-7_Human1.11509411
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10996805
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10914023
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.09307818
90SCL_19346495_ChIP-Seq_HPC-7_Human1.09252366
91* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09031229
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.09012244
93P68_20966046_ChIP-Seq_HELA_Human1.08205289
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06969669
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06795903
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06293050
97SPI1_23547873_ChIP-Seq_NB4_Human1.06191613
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.05436985
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.05436985
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05361488
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04529209
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04396942
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03627104
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.03535433
105MYB_26560356_Chip-Seq_TH1_Human1.03280732
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03146165
107SMC4_20622854_ChIP-Seq_HELA_Human1.02403066
108MAF_26560356_Chip-Seq_TH1_Human1.02376404
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02088402
110GATA1_19941826_ChIP-Seq_K562_Human1.01020513
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00823561
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00641673
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00600360
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99803943
115KDM2B_26808549_Chip-Seq_K562_Human0.99444575
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99092587
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98795027
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97494742
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97074232
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96626786
121RUNX_20019798_ChIP-Seq_JUKART_Human0.96480876
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95887641
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95864077
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95552542
125GATA2_19941826_ChIP-Seq_K562_Human0.95326393
126* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95213445
127SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95011298
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94221263
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93575629
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93146586
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93040178
132ATF3_27146783_Chip-Seq_COLON_Human0.91873487
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91014108
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91014108
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90124982
136EGR1_19032775_ChIP-ChIP_M12_Human0.89171742
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88319929
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88118400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.20683022
2MP0005058_abnormal_lysosome_morphology3.76667602
3MP0003303_peritoneal_inflammation3.23698363
4MP0009840_abnormal_foam_cell3.18604532
5MP0008438_abnormal_cutaneous_collagen2.85564720
6MP0003436_decreased_susceptibility_to2.73095043
7MP0006082_CNS_inflammation2.61694172
8MP0005671_abnormal_response_to2.43163183
9MP0005551_abnormal_eye_electrophysiolog2.37543476
10MP0005257_abnormal_intraocular_pressure2.29595609
11MP0003705_abnormal_hypodermis_morpholog2.29201053
12MP0004510_myositis2.12402058
13MP0003191_abnormal_cellular_cholesterol2.10925248
14MP0003172_abnormal_lysosome_physiology1.98941700
15MP0002419_abnormal_innate_immunity1.96759956
16MP0001835_abnormal_antigen_presentation1.96694424
17MP0002090_abnormal_vision1.91005567
18MP0003300_gastrointestinal_ulcer1.85882424
19MP0000343_altered_response_to1.82459071
20MP0001958_emphysema1.76872062
21MP0001533_abnormal_skeleton_physiology1.74143569
22MP0003950_abnormal_plasma_membrane1.70850132
23MP0005360_urolithiasis1.69675933
24MP0003724_increased_susceptibility_to1.68253869
25MP0003566_abnormal_cell_adhesion1.61644971
26MP0003075_altered_response_to1.58028718
27MP0005451_abnormal_body_composition1.56590918
28MP0002148_abnormal_hypersensitivity_rea1.55734482
29MP0005464_abnormal_platelet_physiology1.51435259
30MP0005000_abnormal_immune_tolerance1.50674951
31MP0002998_abnormal_bone_remodeling1.50321883
32MP0005253_abnormal_eye_physiology1.49040354
33MP0010155_abnormal_intestine_physiology1.45700204
34MP0003690_abnormal_glial_cell1.44693167
35MP0009785_altered_susceptibility_to1.44671699
36MP0004019_abnormal_vitamin_homeostasis1.43802489
37MP0003329_amyloid_beta_deposits1.43222190
38* MP0005025_abnormal_response_to1.42569744
39MP0005167_abnormal_blood-brain_barrier1.42549501
40MP0003279_aneurysm1.40970195
41MP0003763_abnormal_thymus_physiology1.38834615
42MP0005387_immune_system_phenotype1.38598173
43MP0001790_abnormal_immune_system1.38598173
44MP0003252_abnormal_bile_duct1.33305333
45MP0000858_altered_metastatic_potential1.32281256
46MP0010368_abnormal_lymphatic_system1.32075409
47MP0002138_abnormal_hepatobiliary_system1.31650314
48MP0003448_altered_tumor_morphology1.31466648
49MP0001324_abnormal_eye_pigmentation1.30071334
50* MP0000716_abnormal_immune_system1.29920787
51MP0005275_abnormal_skin_tensile1.29617909
52MP0008260_abnormal_autophagy1.28824648
53MP0004130_abnormal_muscle_cell1.28652203
54MP0002452_abnormal_antigen_presenting1.28493118
55MP0009764_decreased_sensitivity_to1.27183332
56MP0003183_abnormal_peptide_metabolism1.27150083
57MP0008469_abnormal_protein_level1.22689343
58MP0008004_abnormal_stomach_pH1.21338993
59MP0003828_pulmonary_edema1.17819721
60MP0000920_abnormal_myelination1.17819203
61MP0003195_calcinosis1.16861372
62MP0001845_abnormal_inflammatory_respons1.16247714
63MP0005166_decreased_susceptibility_to1.15673269
64MP0008875_abnormal_xenobiotic_pharmacok1.15150165
65MP0000750_abnormal_muscle_regeneration1.15000261
66MP0001879_abnormal_lymphatic_vessel1.14815859
67MP0002254_reproductive_system_inflammat1.14618285
68* MP0002398_abnormal_bone_marrow1.13798437
69MP0000767_abnormal_smooth_muscle1.12187952
70MP0000685_abnormal_immune_system1.11971781
71MP0009278_abnormal_bone_marrow1.10417947
72MP0005076_abnormal_cell_differentiation1.10164326
73MP0000604_amyloidosis1.10093110
74MP0004883_abnormal_blood_vessel1.09641662
75MP0005197_abnormal_uvea_morphology1.08920894
76MP0010329_abnormal_lipoprotein_level1.08917334
77MP0004947_skin_inflammation1.08693692
78MP0001853_heart_inflammation1.06833502
79* MP0002723_abnormal_immune_serum1.05565353
80MP0001851_eye_inflammation1.05009267
81MP0002139_abnormal_hepatobiliary_system1.03176287
82MP0004185_abnormal_adipocyte_glucose1.02594024
83MP0005390_skeleton_phenotype1.01485620
84MP0003879_abnormal_hair_cell0.99874695
85MP0005195_abnormal_posterior_eye0.99408324
86MP0001800_abnormal_humoral_immune0.97285089
87MP0004084_abnormal_cardiac_muscle0.97090789
88MP0005023_abnormal_wound_healing0.97020699
89MP0000465_gastrointestinal_hemorrhage0.96238415
90MP0002405_respiratory_system_inflammati0.95954302
91* MP0002429_abnormal_blood_cell0.95064161
92MP0005319_abnormal_enzyme/_coenzyme0.95053300
93MP0000609_abnormal_liver_physiology0.94412429
94MP0000249_abnormal_blood_vessel0.94062663
95MP0010307_abnormal_tumor_latency0.93855319
96MP0001764_abnormal_homeostasis0.93819916
97MP0005164_abnormal_response_to0.93660927
98MP0003866_abnormal_defecation0.93402003
99MP0005165_increased_susceptibility_to0.92591043
100* MP0000689_abnormal_spleen_morphology0.92252491
101MP0008874_decreased_physiological_sensi0.91797957
102MP0001545_abnormal_hematopoietic_system0.89874556
103MP0005397_hematopoietic_system_phenotyp0.89874556
104MP0005670_abnormal_white_adipose0.89522818
105MP0009333_abnormal_splenocyte_physiolog0.89132602
106MP0001542_abnormal_bone_strength0.88805363
107MP0001819_abnormal_immune_cell0.88730498
108MP0003656_abnormal_erythrocyte_physiolo0.88016231
109MP0004272_abnormal_basement_membrane0.87741053
110MP0001756_abnormal_urination0.87683118
111MP0003091_abnormal_cell_migration0.87658993
112MP0005365_abnormal_bile_salt0.87254150
113MP0002136_abnormal_kidney_physiology0.87076885
114* MP0002722_abnormal_immune_system0.87071828
115MP0002420_abnormal_adaptive_immunity0.86684892
116MP0002132_abnormal_respiratory_system0.83895403
117MP0005332_abnormal_amino_acid0.83875004
118MP0002933_joint_inflammation0.82900309
119MP0003795_abnormal_bone_structure0.82415884
120MP0003045_fibrosis0.81926513
121MP0009643_abnormal_urine_homeostasis0.81045645
122MP0005310_abnormal_salivary_gland0.80348585
123MP0009763_increased_sensitivity_to0.79808467
124MP0002971_abnormal_brown_adipose0.79703554
125MP0002332_abnormal_exercise_endurance0.78547520
126MP0005503_abnormal_tendon_morphology0.78181507
127MP0005083_abnormal_biliary_tract0.77743522
128MP0005595_abnormal_vascular_smooth0.75795601
129MP0001663_abnormal_digestive_system0.75774293
130MP0005666_abnormal_adipose_tissue0.74160156
131MP0001873_stomach_inflammation0.73883501
132MP0005535_abnormal_body_temperature0.73726677
133MP0005388_respiratory_system_phenotype0.71587681
134MP0002133_abnormal_respiratory_system0.71587681
135MP0004858_abnormal_nervous_system0.71051694
136MP0000703_abnormal_thymus_morphology0.68024491
137MP0004381_abnormal_hair_follicle0.66811656
138MP0001501_abnormal_sleep_pattern0.66708608
139MP0001849_ear_inflammation0.65906182

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.59644427
2Increased cerebral lipofuscin (HP:0011813)5.28219262
3Pigmentary retinal degeneration (HP:0001146)4.93299420
4Systemic lupus erythematosus (HP:0002725)4.90858707
5Axonal loss (HP:0003447)4.58673961
6Vacuolated lymphocytes (HP:0001922)4.38109190
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.33553217
8Bony spicule pigmentary retinopathy (HP:0007737)4.28554359
9Recurrent gram-negative bacterial infections (HP:0005420)4.05143043
10Recurrent abscess formation (HP:0002722)3.87389567
11Dysostosis multiplex (HP:0000943)3.83516512
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.76250127
13Abnormality of liposaccharide metabolism (HP:0010968)3.72572172
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.72572172
15Abnormality of glycolipid metabolism (HP:0010969)3.72572172
16Eczematoid dermatitis (HP:0000976)3.69786836
17Dyschromatopsia (HP:0007641)3.68603266
18Chorioretinal atrophy (HP:0000533)3.67319403
19Retinal atrophy (HP:0001105)3.64927026
20Abnormal rod and cone electroretinograms (HP:0008323)3.63359624
21Abnormality of macrophages (HP:0004311)3.56685749
22Glomerulonephritis (HP:0000099)3.54889347
23Recurrent bacterial skin infections (HP:0005406)3.36744711
24Retrobulbar optic neuritis (HP:0100654)3.34202313
25Optic neuritis (HP:0100653)3.34202313
26Mucopolysacchariduria (HP:0008155)3.23247869
27Urinary glycosaminoglycan excretion (HP:0003541)3.23247869
28Stomatitis (HP:0010280)3.20317575
29Progressive visual loss (HP:0000529)3.19831606
30Abolished electroretinogram (ERG) (HP:0000550)3.10226633
31Abnormality of polysaccharide metabolism (HP:0011012)3.08974860
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08974860
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08974860
34Complement deficiency (HP:0004431)3.08527526
35Abnormality of macular pigmentation (HP:0008002)3.07502207
36Central scotoma (HP:0000603)3.02149622
37Asymmetric septal hypertrophy (HP:0001670)3.00319174
38Myocardial infarction (HP:0001658)2.95029240
39Interstitial pulmonary disease (HP:0006530)2.90924062
40Chronic obstructive pulmonary disease (HP:0006510)2.88067684
41Obstructive lung disease (HP:0006536)2.88067684
42Disinhibition (HP:0000734)2.86700698
43Autoimmune thrombocytopenia (HP:0001973)2.86163619
44Recurrent fungal infections (HP:0002841)2.83770794
45Attenuation of retinal blood vessels (HP:0007843)2.81620553
46Nephritis (HP:0000123)2.81205209
47Scotoma (HP:0000575)2.80408491
48Abnormality of complement system (HP:0005339)2.80359191
49Increased IgE level (HP:0003212)2.76874138
50Purpura (HP:0000979)2.71639140
51Pendular nystagmus (HP:0012043)2.71428066
52Cerebral aneurysm (HP:0004944)2.71189990
53Loss of speech (HP:0002371)2.66469940
54Meningitis (HP:0001287)2.65491311
55Gastrointestinal infarctions (HP:0005244)2.62162267
56Pulmonary infiltrates (HP:0002113)2.60917853
57Cellulitis (HP:0100658)2.60620939
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58638013
59Keratoconjunctivitis sicca (HP:0001097)2.48651588
60Neurofibrillary tangles (HP:0002185)2.47271838
61* Vasculitis (HP:0002633)2.42896468
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42033709
63Keratoconjunctivitis (HP:0001096)2.40951685
64Hemoptysis (HP:0002105)2.39287125
65Recurrent cutaneous fungal infections (HP:0011370)2.39232045
66Chronic mucocutaneous candidiasis (HP:0002728)2.39232045
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.38603428
68Macular degeneration (HP:0000608)2.37623400
69Premature rupture of membranes (HP:0001788)2.36588382
70Prolonged bleeding time (HP:0003010)2.36181162
71Gingivitis (HP:0000230)2.32587224
72Decreased central vision (HP:0007663)2.27986144
73Petechiae (HP:0000967)2.27825461
74Pustule (HP:0200039)2.27635944
75Increased corneal curvature (HP:0100692)2.26422691
76Keratoconus (HP:0000563)2.26422691
77Obstructive sleep apnea (HP:0002870)2.25553377
78Hematochezia (HP:0002573)2.22754086
79Photophobia (HP:0000613)2.22269503
80Protrusio acetabuli (HP:0003179)2.21523951
81Mutism (HP:0002300)2.20262991
82Vertebral compression fractures (HP:0002953)2.18733773
83Joint hemorrhage (HP:0005261)2.16888378
84Supranuclear gaze palsy (HP:0000605)2.16644510
85Epistaxis (HP:0000421)2.15975281
86Amyloidosis (HP:0011034)2.14512332
87Encephalitis (HP:0002383)2.14306060
88Abnormality of the nasal mucosa (HP:0000433)2.13561944
89Episodic fever (HP:0001954)2.13529590
90Xanthomatosis (HP:0000991)2.11066696
91Inflammation of the large intestine (HP:0002037)2.10539344
92Chest pain (HP:0100749)2.10429583
93Pulmonary embolism (HP:0002204)2.10399888
94Diplopia (HP:0000651)2.08688267
95Abnormality of binocular vision (HP:0011514)2.08688267
96Gastrointestinal inflammation (HP:0004386)2.06420246
97Increased variability in muscle fiber diameter (HP:0003557)2.05354135
98Deep venous thrombosis (HP:0002625)2.03593235
99Colitis (HP:0002583)2.03331640
100Peritonitis (HP:0002586)2.01625033
101Progressive neurologic deterioration (HP:0002344)2.01214634
102Peripheral demyelination (HP:0011096)2.00981575
103Pathologic fracture (HP:0002756)2.00925287
104Esophageal varix (HP:0002040)2.00704298
105Gingival bleeding (HP:0000225)2.00399571
106Neuronal loss in central nervous system (HP:0002529)2.00030052
107Basal ganglia calcification (HP:0002135)1.98910752
108Recurrent skin infections (HP:0001581)1.98349780
109Cone-rod dystrophy (HP:0000548)1.98177003
110Polygenic inheritance (HP:0010982)1.96610517
111Hepatosplenomegaly (HP:0001433)1.95571621
112Nuclear cataract (HP:0100018)1.94814094
113Increased serum ferritin (HP:0003281)1.94642846
114Broad metatarsal (HP:0001783)1.94583652
115Nausea (HP:0002018)1.94095707
116Spontaneous hematomas (HP:0007420)1.93754049
117Hypergammaglobulinemia (HP:0010702)1.93575259
118Muscle fiber splitting (HP:0003555)1.93309604
119Mediastinal lymphadenopathy (HP:0100721)1.92738695
120Choroideremia (HP:0001139)1.91801788
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91673284
122Abnormality of skeletal muscle fiber size (HP:0012084)1.91370194
123Papilledema (HP:0001085)1.90877025
124Hypercholesterolemia (HP:0003124)1.90419833
125Increased IgM level (HP:0003496)1.90127359
126T lymphocytopenia (HP:0005403)1.89983058
127Increased connective tissue (HP:0009025)1.89897985
128Prostate neoplasm (HP:0100787)1.89883207
129Cervical subluxation (HP:0003308)1.88205548
130Recurrent viral infections (HP:0004429)1.88078028
131Myositis (HP:0100614)1.87968925
132Upper motor neuron abnormality (HP:0002127)1.87195140
133* Emphysema (HP:0002097)1.86910189
134Vertigo (HP:0002321)1.86614563
135Urticaria (HP:0001025)1.85478918
136Increased CSF protein (HP:0002922)1.84854432
137Type II diabetes mellitus (HP:0005978)1.84218333
138Aortic aneurysm (HP:0004942)1.83779051
139Hypertriglyceridemia (HP:0002155)1.83701776
140Constricted visual fields (HP:0001133)1.83563367
141Cerebral inclusion bodies (HP:0100314)1.82951050
142Acne (HP:0001061)1.82321470
143Aortic dissection (HP:0002647)1.82156599
144Posterior subcapsular cataract (HP:0007787)1.81584684
145Thoracic kyphosis (HP:0002942)1.81351515
146Polycythemia (HP:0001901)1.81256484
147J-shaped sella turcica (HP:0002680)1.81118438
148Shallow orbits (HP:0000586)1.80229066
149Conjunctival telangiectasia (HP:0000524)1.79607480
150Elevated erythrocyte sedimentation rate (HP:0003565)1.79456289
151Orchitis (HP:0100796)1.79136348
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76530341
153Ovoid vertebral bodies (HP:0003300)1.76114908
154Vitreoretinal degeneration (HP:0000655)1.74420311
155Subcapsular cataract (HP:0000523)1.74090428
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.73429037
157Osteolytic defects of the hand bones (HP:0009699)1.73429037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.73769203
2TRIB33.74740901
3PRPF4B2.87435681
4KIT2.81774136
5TBK12.64928208
6TGFBR22.56240869
7TTN2.55740070
8PBK2.22111989
9MAP3K132.19620360
10RIPK12.19430562
11GRK12.16404008
12PKN22.05565191
13TAOK31.98444884
14TYK21.85295154
15PIK3CG1.84001019
16IRAK31.82841871
17TNK21.79356312
18CAMK1D1.76100110
19NEK91.72593146
20BLK1.67195973
21MAP3K141.66302076
22RIPK41.59962361
23NME21.57055267
24SIK11.50821419
25TAOK11.49997708
26PTK61.46776075
27GRK61.41638700
28MAP2K31.40138676
29BMX1.36525898
30EPHB11.33851158
31TXK1.33219466
32MAP4K11.32700197
33JAK11.32022089
34FGR1.30650915
35PIM21.27358751
36RPS6KA41.25042698
37CDC42BPA1.24652055
38TAOK21.24293282
39ABL21.21026186
40CAMK1G1.18482477
41MARK21.17275961
42IKBKB1.15466677
43PDK21.14596532
44BTK1.13284274
45IRAK41.11174169
46MAP3K31.08195158
47TIE11.08083461
48PRKG21.07409889
49IKBKE1.06390833
50MYLK1.04695088
51CSK1.04606217
52KDR1.04510066
53STK241.04490590
54TESK11.01635212
55ZAP701.01627161
56KSR21.00005785
57MST1R0.98517632
58MAPK120.94803917
59JAK30.92526671
60JAK20.92221630
61HCK0.89427460
62PDK10.87407150
63TESK20.87338290
64DAPK20.87087657
65MAP3K110.84907547
66SIK30.82855752
67PRKCH0.82304314
68FGFR40.82168221
69STK38L0.82125916
70MAP3K70.81484513
71EPHB20.81075446
72DMPK0.80525856
73PINK10.80384553
74ITK0.80211070
75CHUK0.79629785
76PAK40.79507328
77ARAF0.78943765
78MOS0.75651717
79PDGFRA0.74276734
80MAP3K60.73950203
81STK30.73537195
82FES0.72277953
83LRRK20.71125905
84PAK60.71001530
85HIPK20.70403742
86CSF1R0.70229925
87MAP3K100.69263285
88MATK0.68730778
89BCKDK0.65287762
90PIM10.64748641
91FYN0.63935209
92SIK20.62849081
93PRKD10.61938355
94MAP3K10.60844183
95GSK3A0.60529686
96MAPK70.60275698
97PDPK10.59960992
98CDK120.58289362
99STK380.57876280
100PTK2B0.56857788
101RPS6KC10.56633674
102RPS6KL10.56633674
103RPS6KA20.56095083
104MARK30.55271045
105ABL10.54781069
106CASK0.53999812
107MAP2K60.53624935
108EGFR0.53315078
109MAPK40.51319391
110PRKD30.50928045
111PTK20.50020543
112CDK60.49916348
113FGFR30.49108107
114CAMK10.48425482
115SGK30.48247020
116GRK50.48223521
117CAMKK10.48208552
118DAPK30.48101497
119LATS10.47219164
120PRKD20.46884780
121PAK20.46746325
122PRKAA20.46471000
123PDGFRB0.45910383
124RPS6KA60.45258652
125FLT30.45098129
126GRK70.44895848
127STK100.44401268
128IRAK20.44256393
129CAMKK20.43979737
130DYRK1B0.42354873
131SYK0.41393950
132MAP2K20.41181682
133CAMK40.40728867
134DDR20.40317490
135TYRO30.40119210
136LCK0.39868186
137EPHA30.39759260
138LYN0.38868547
139RET0.38856846
140BMPR20.38223831
141MAP3K50.37487936
142TRPM70.37257450

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.21942716
2Staphylococcus aureus infection_Homo sapiens_hsa051503.37053711
3Lysosome_Homo sapiens_hsa041423.08888443
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.01362269
5Other glycan degradation_Homo sapiens_hsa005112.23128799
6Complement and coagulation cascades_Homo sapiens_hsa046102.09472243
7Leishmaniasis_Homo sapiens_hsa051402.07805110
8Allograft rejection_Homo sapiens_hsa053302.07632594
9Caffeine metabolism_Homo sapiens_hsa002321.97209943
10Autoimmune thyroid disease_Homo sapiens_hsa053201.88141075
11Osteoclast differentiation_Homo sapiens_hsa043801.86283866
12Malaria_Homo sapiens_hsa051441.85113841
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61817797
14Tuberculosis_Homo sapiens_hsa051521.58265443
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57038093
16Pertussis_Homo sapiens_hsa051331.51323246
17Type I diabetes mellitus_Homo sapiens_hsa049401.49212358
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.47986848
19Rheumatoid arthritis_Homo sapiens_hsa053231.47198759
20Phagosome_Homo sapiens_hsa041451.41773223
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38301587
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36916768
23Nitrogen metabolism_Homo sapiens_hsa009101.36802714
24Primary immunodeficiency_Homo sapiens_hsa053401.28279298
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24442833
26Amoebiasis_Homo sapiens_hsa051461.19704393
27PPAR signaling pathway_Homo sapiens_hsa033201.13552815
28T cell receptor signaling pathway_Homo sapiens_hsa046601.13532046
29Toxoplasmosis_Homo sapiens_hsa051451.10633762
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.06850934
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06020946
32Legionellosis_Homo sapiens_hsa051341.05675616
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04607865
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04459475
35TNF signaling pathway_Homo sapiens_hsa046680.99515621
36Arginine biosynthesis_Homo sapiens_hsa002200.96524521
37Adipocytokine signaling pathway_Homo sapiens_hsa049200.93826392
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92826729
39VEGF signaling pathway_Homo sapiens_hsa043700.91604677
40Fatty acid degradation_Homo sapiens_hsa000710.89974451
41Phospholipase D signaling pathway_Homo sapiens_hsa040720.89944491
42B cell receptor signaling pathway_Homo sapiens_hsa046620.88322254
43Salmonella infection_Homo sapiens_hsa051320.86512819
44Apoptosis_Homo sapiens_hsa042100.86134346
45GnRH signaling pathway_Homo sapiens_hsa049120.86127147
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84397333
47Insulin resistance_Homo sapiens_hsa049310.83651609
48Herpes simplex infection_Homo sapiens_hsa051680.82391497
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.81838259
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81785260
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81663762
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.81340542
53Chemokine signaling pathway_Homo sapiens_hsa040620.77585192
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75598112
55Chronic myeloid leukemia_Homo sapiens_hsa052200.74895909
56Acute myeloid leukemia_Homo sapiens_hsa052210.72844637
57Influenza A_Homo sapiens_hsa051640.72807396
58Long-term potentiation_Homo sapiens_hsa047200.70434554
59Measles_Homo sapiens_hsa051620.70432890
60Focal adhesion_Homo sapiens_hsa045100.70301675
61Prion diseases_Homo sapiens_hsa050200.69306170
62Starch and sucrose metabolism_Homo sapiens_hsa005000.68998360
63ECM-receptor interaction_Homo sapiens_hsa045120.68342534
64Collecting duct acid secretion_Homo sapiens_hsa049660.67681560
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67027219
66Antigen processing and presentation_Homo sapiens_hsa046120.65841887
67Proteoglycans in cancer_Homo sapiens_hsa052050.65823589
68Non-small cell lung cancer_Homo sapiens_hsa052230.65180862
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64003219
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63809945
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63679843
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.62848957
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.62441840
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62400254
75Dilated cardiomyopathy_Homo sapiens_hsa054140.61406037
76Synaptic vesicle cycle_Homo sapiens_hsa047210.60365930
77MAPK signaling pathway_Homo sapiens_hsa040100.60362072
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60301392
79Renin secretion_Homo sapiens_hsa049240.58646279
80Prolactin signaling pathway_Homo sapiens_hsa049170.57556406
81Platelet activation_Homo sapiens_hsa046110.57393783
82Hepatitis C_Homo sapiens_hsa051600.57200125
83Retinol metabolism_Homo sapiens_hsa008300.57044626
84Estrogen signaling pathway_Homo sapiens_hsa049150.55742986
85Rap1 signaling pathway_Homo sapiens_hsa040150.55647357
86Mineral absorption_Homo sapiens_hsa049780.54749313
87HIF-1 signaling pathway_Homo sapiens_hsa040660.54530857
88* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54311185
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53560770
90Galactose metabolism_Homo sapiens_hsa000520.53088857
91Shigellosis_Homo sapiens_hsa051310.52528361
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52304076
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51428831
94ABC transporters_Homo sapiens_hsa020100.51257268
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50444566
96Endocytosis_Homo sapiens_hsa041440.50387257
97Pancreatic cancer_Homo sapiens_hsa052120.50349934
98Small cell lung cancer_Homo sapiens_hsa052220.49856880
99Dorso-ventral axis formation_Homo sapiens_hsa043200.49821205
100Bile secretion_Homo sapiens_hsa049760.49670217
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49285170
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.49091335
103Tryptophan metabolism_Homo sapiens_hsa003800.48591254
104Type II diabetes mellitus_Homo sapiens_hsa049300.48480840
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47639775
106Gastric acid secretion_Homo sapiens_hsa049710.47097807
107Choline metabolism in cancer_Homo sapiens_hsa052310.47097196
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.46926997
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46722652
110Oxytocin signaling pathway_Homo sapiens_hsa049210.46413355
111Viral myocarditis_Homo sapiens_hsa054160.46378528
112Fatty acid metabolism_Homo sapiens_hsa012120.46287940
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43751275
114Hematopoietic cell lineage_Homo sapiens_hsa046400.43653398
115Asthma_Homo sapiens_hsa053100.43141953
116Ras signaling pathway_Homo sapiens_hsa040140.42821554
117Peroxisome_Homo sapiens_hsa041460.42480222
118HTLV-I infection_Homo sapiens_hsa051660.42247596
119Insulin signaling pathway_Homo sapiens_hsa049100.42066085
120Renal cell carcinoma_Homo sapiens_hsa052110.41633882
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39775663
122Hepatitis B_Homo sapiens_hsa051610.39704378
123Notch signaling pathway_Homo sapiens_hsa043300.39668932
124Renin-angiotensin system_Homo sapiens_hsa046140.39666576
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38792619
126Graft-versus-host disease_Homo sapiens_hsa053320.38341809
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38141429
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37794856
129Histidine metabolism_Homo sapiens_hsa003400.37526628
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37410442
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37261668
132African trypanosomiasis_Homo sapiens_hsa051430.36651497
133beta-Alanine metabolism_Homo sapiens_hsa004100.35920572
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34870393

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