TNFSF12-TNFSF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.02558980
2response to peptidoglycan (GO:0032494)5.56711072
3negative regulation of interleukin-12 production (GO:0032695)5.45031587
4immunoglobulin mediated immune response (GO:0016064)4.91955041
5macrophage activation involved in immune response (GO:0002281)4.88999559
6positive regulation by symbiont of host defense response (GO:0052509)4.85456507
7modulation by symbiont of host defense response (GO:0052031)4.85456507
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.85456507
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.85456507
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.85456507
11modulation by symbiont of host immune response (GO:0052553)4.85456507
12positive regulation of gamma-delta T cell activation (GO:0046645)4.75713007
13negative regulation of cell killing (GO:0031342)4.41953011
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41953011
15detection of other organism (GO:0098543)4.32093097
16regulation of mast cell degranulation (GO:0043304)4.22191084
17detection of bacterium (GO:0016045)4.21586579
18positive regulation of mast cell degranulation (GO:0043306)3.92893381
19positive regulation of mast cell activation involved in immune response (GO:0033008)3.92893381
20regulation of mast cell activation involved in immune response (GO:0033006)3.92265615
21positive regulation of mast cell activation (GO:0033005)3.92025118
22granulocyte activation (GO:0036230)3.85591602
23detection of molecule of bacterial origin (GO:0032490)3.81040471
24myeloid cell activation involved in immune response (GO:0002275)3.76526638
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75790771
26detection of external biotic stimulus (GO:0098581)3.74780297
27B cell mediated immunity (GO:0019724)3.69082680
28neutrophil activation (GO:0042119)3.66799157
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62575186
30regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62122526
31regulation of leukocyte degranulation (GO:0043300)3.60345642
32regulation of mast cell activation (GO:0033003)3.47729625
33response to muramyl dipeptide (GO:0032495)3.47463071
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46438669
35macrophage activation (GO:0042116)3.42905432
36cellular response to thyroid hormone stimulus (GO:0097067)3.38989411
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.38232643
38regulation of gamma-delta T cell activation (GO:0046643)3.36908072
39positive regulation of antigen processing and presentation (GO:0002579)3.36250331
40positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.35582726
41negative regulation of cytokine production involved in immune response (GO:0002719)3.35395395
42myeloid dendritic cell differentiation (GO:0043011)3.35069639
43interferon-gamma-mediated signaling pathway (GO:0060333)3.32905132
44detection of biotic stimulus (GO:0009595)3.31994287
45positive regulation of leukocyte degranulation (GO:0043302)3.31880884
46antigen processing and presentation of endogenous antigen (GO:0019883)3.29410331
47microglial cell activation (GO:0001774)3.28905747
48regulation of antigen processing and presentation (GO:0002577)3.27981006
49respiratory burst (GO:0045730)3.25489490
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25388826
51response to host immune response (GO:0052572)3.25388826
52regulation of interferon-beta biosynthetic process (GO:0045357)3.24912029
53amino sugar catabolic process (GO:0046348)3.22678899
54defense response to protozoan (GO:0042832)3.21300496
55myeloid dendritic cell activation (GO:0001773)3.20344557
56NIK/NF-kappaB signaling (GO:0038061)3.15847832
57positive regulation of cellular amide metabolic process (GO:0034250)3.11577937
58glycosphingolipid catabolic process (GO:0046479)3.10953081
59type I interferon signaling pathway (GO:0060337)3.09033868
60cellular response to type I interferon (GO:0071357)3.09033868
61leukocyte aggregation (GO:0070486)3.08375158
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08362573
63response to protozoan (GO:0001562)3.07965907
64cellular extravasation (GO:0045123)3.06434282
65T-helper 1 type immune response (GO:0042088)3.05631541
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05567754
67response to type I interferon (GO:0034340)3.04578737
68regulation of B cell receptor signaling pathway (GO:0050855)3.00574605
69negative regulation of erythrocyte differentiation (GO:0045647)2.99869815
70negative regulation of myeloid cell apoptotic process (GO:0033033)2.97221429
71regulation of T cell tolerance induction (GO:0002664)2.97163749
72regulation of T-helper 2 cell differentiation (GO:0045628)2.96909344
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96395985
74regulation of mononuclear cell migration (GO:0071675)2.96310562
75regulation of hypersensitivity (GO:0002883)2.96120290
76regulation of regulated secretory pathway (GO:1903305)2.94359035
77positive regulation of isotype switching (GO:0045830)2.94358316
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93952833
79response to host (GO:0075136)2.93952833
80response to host defenses (GO:0052200)2.93952833
81positive regulation of humoral immune response (GO:0002922)2.87230591
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85885940
83regulation of macrophage chemotaxis (GO:0010758)2.85714604
84positive regulation of type 2 immune response (GO:0002830)2.85264688
85myeloid leukocyte activation (GO:0002274)2.84123323
86oligosaccharide catabolic process (GO:0009313)2.81751549
87germinal center formation (GO:0002467)2.81184859
88positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80761285
89positive regulation of B cell mediated immunity (GO:0002714)2.80761285
90leukocyte degranulation (GO:0043299)2.79746710
91regulation of tolerance induction (GO:0002643)2.79483829
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79216961
93regulation of interferon-alpha production (GO:0032647)2.77084373
94glycolipid catabolic process (GO:0019377)2.76247081
95negative regulation of leukocyte mediated immunity (GO:0002704)2.76003989
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73817829
97negative regulation of lymphocyte mediated immunity (GO:0002707)2.73608306
98negative regulation of T cell mediated immunity (GO:0002710)2.73523808
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.72913878
100negative regulation of innate immune response (GO:0045824)2.71815160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.47126073
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.03585392
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.02709534
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.64958487
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58619274
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.45933229
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20720757
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06132990
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92407241
10VDR_21846776_ChIP-Seq_THP-1_Human2.86115380
11VDR_24763502_ChIP-Seq_THP-1_Human2.75757852
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73845924
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71646403
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69385826
15SPI1_23127762_ChIP-Seq_K562_Human2.50728973
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49037856
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47717225
18SPI1_23547873_ChIP-Seq_NB4_Human2.46729761
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36438298
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33501051
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31467062
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14703279
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13100856
24VDR_24787735_ChIP-Seq_THP-1_Human2.07519236
25SCL_19346495_ChIP-Seq_HPC-7_Human2.06495508
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05168974
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.04207517
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.01383060
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01283887
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.00218072
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92597333
32RUNX_20019798_ChIP-Seq_JUKART_Human1.90430286
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75354657
34MAF_26560356_Chip-Seq_TH1_Human1.75136614
35EZH2_22144423_ChIP-Seq_EOC_Human1.72985951
36MYB_26560356_Chip-Seq_TH2_Human1.68967957
37* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67386191
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67215941
39UTX_26944678_Chip-Seq_JUKART_Human1.67126727
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66716513
41TCF7_22412390_ChIP-Seq_EML_Mouse1.55213404
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54737530
43MYC_22102868_ChIP-Seq_BL_Human1.53924918
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51573831
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.51469389
46LXR_22292898_ChIP-Seq_THP-1_Human1.50991930
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47161947
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46590449
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44795274
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43190849
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42752122
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40920357
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.40358996
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39049017
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37879688
56KDM2B_26808549_Chip-Seq_DND41_Human1.36514176
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35648217
58* MYB_26560356_Chip-Seq_TH1_Human1.34931255
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34672476
60MAF_26560356_Chip-Seq_TH2_Human1.34455661
61* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32742761
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32428052
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31061296
64* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30251856
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29307157
66BCL6_27268052_Chip-Seq_Bcells_Human1.27919867
67BCOR_27268052_Chip-Seq_Bcells_Human1.27565434
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26698697
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26697378
70* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22905795
71* PU_27001747_Chip-Seq_BMDM_Mouse1.19315825
72TFEB_21752829_ChIP-Seq_HELA_Human1.19190171
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17889208
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16226057
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15258301
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14393900
77GATA3_27048872_Chip-Seq_THYMUS_Human1.14318793
78STAT1_20625510_ChIP-Seq_HELA_Human1.09357725
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.07701729
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06514331
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05715880
82GATA1_19941826_ChIP-Seq_K562_Human1.05596819
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04469037
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03435203
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02791299
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02301425
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.97694646
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97492447
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.96872181
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96635864
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96228538
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93187873
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91972975
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91736935
95GATA3_26560356_Chip-Seq_TH2_Human0.91413799
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86907958
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.85241287
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84801657
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83953940
100NCOR1_26117541_ChIP-Seq_K562_Human0.83105652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.06176116
2MP0005058_abnormal_lysosome_morphology3.96112412
3MP0003436_decreased_susceptibility_to3.80544255
4MP0006082_CNS_inflammation3.64091462
5MP0003724_increased_susceptibility_to3.46207838
6MP0001835_abnormal_antigen_presentation3.24374081
7MP0002148_abnormal_hypersensitivity_rea3.07327569
8MP0002419_abnormal_innate_immunity3.06558633
9MP0009785_altered_susceptibility_to2.99201512
10MP0009840_abnormal_foam_cell2.94959584
11MP0005000_abnormal_immune_tolerance2.73541970
12MP0005387_immune_system_phenotype2.71853189
13MP0001790_abnormal_immune_system2.71853189
14MP0005671_abnormal_response_to2.67585967
15MP0005025_abnormal_response_to2.67428739
16MP0000685_abnormal_immune_system2.51572820
17MP0003172_abnormal_lysosome_physiology2.51511486
18MP0002452_abnormal_antigen_presenting2.39312253
19MP0001800_abnormal_humoral_immune2.35592270
20MP0002723_abnormal_immune_serum2.34343956
21MP0004510_myositis2.31369405
22MP0003300_gastrointestinal_ulcer2.29576109
23MP0002139_abnormal_hepatobiliary_system2.24171113
24MP0003191_abnormal_cellular_cholesterol2.21142520
25MP0002420_abnormal_adaptive_immunity2.16522146
26MP0001819_abnormal_immune_cell2.13981080
27MP0001533_abnormal_skeleton_physiology2.05398908
28MP0003075_altered_response_to1.98459843
29MP0009278_abnormal_bone_marrow1.94266406
30MP0005464_abnormal_platelet_physiology1.91857735
31MP0000343_altered_response_to1.87724393
32MP0009764_decreased_sensitivity_to1.78886638
33MP0001845_abnormal_inflammatory_respons1.76312598
34MP0002405_respiratory_system_inflammati1.74498179
35MP0003183_abnormal_peptide_metabolism1.71590727
36MP0003806_abnormal_nucleotide_metabolis1.70750128
37MP0002138_abnormal_hepatobiliary_system1.70229944
38MP0008260_abnormal_autophagy1.70015727
39MP0001853_heart_inflammation1.68291983
40MP0010155_abnormal_intestine_physiology1.67836387
41MP0002998_abnormal_bone_remodeling1.67761230
42MP0008469_abnormal_protein_level1.66698358
43MP0005310_abnormal_salivary_gland1.59340232
44MP0000604_amyloidosis1.56852245
45MP0005397_hematopoietic_system_phenotyp1.55277831
46MP0001545_abnormal_hematopoietic_system1.55277831
47MP0000716_abnormal_immune_system1.52223537
48MP0004947_skin_inflammation1.51186560
49MP0009333_abnormal_splenocyte_physiolog1.49583017
50MP0003690_abnormal_glial_cell1.43731973
51MP0002398_abnormal_bone_marrow1.39033797
52MP0003828_pulmonary_edema1.38547848
53MP0000858_altered_metastatic_potential1.36629135
54MP0005166_decreased_susceptibility_to1.33147588
55MP0008004_abnormal_stomach_pH1.32562095
56MP0003448_altered_tumor_morphology1.28941271
57MP0000689_abnormal_spleen_morphology1.24706505
58MP0002429_abnormal_blood_cell1.17191769
59MP0003453_abnormal_keratinocyte_physiol1.12366984
60MP0000465_gastrointestinal_hemorrhage1.10012500
61MP0005451_abnormal_body_composition1.09624883
62MP0002722_abnormal_immune_system1.09425242
63MP0005167_abnormal_blood-brain_barrier1.04285875
64MP0003763_abnormal_thymus_physiology1.03374057
65MP0003879_abnormal_hair_cell1.03148610
66MP0006054_spinal_hemorrhage0.91755917
67MP0002277_abnormal_respiratory_mucosa0.91618059
68MP0005390_skeleton_phenotype0.91441355
69MP0002254_reproductive_system_inflammat0.90622258
70MP0009763_increased_sensitivity_to0.84839464
71MP0005164_abnormal_response_to0.83069626
72MP0003656_abnormal_erythrocyte_physiolo0.82715668
73MP0004883_abnormal_blood_vessel0.82262311
74MP0001851_eye_inflammation0.79867783
75MP0000920_abnormal_myelination0.79298306
76MP0005319_abnormal_enzyme/_coenzyme0.78866402
77MP0003718_maternal_effect0.78193198
78MP0001663_abnormal_digestive_system0.77450996
79MP0003795_abnormal_bone_structure0.73423723
80MP0001873_stomach_inflammation0.72840778
81MP0003866_abnormal_defecation0.72799317
82MP0001542_abnormal_bone_strength0.71701772
83MP0010307_abnormal_tumor_latency0.71394670
84MP0000490_abnormal_crypts_of0.69571149
85MP0002132_abnormal_respiratory_system0.69400731
86MP0000703_abnormal_thymus_morphology0.68484205
87MP0005365_abnormal_bile_salt0.64558663
88MP0005647_abnormal_sex_gland0.63634087
89MP0003091_abnormal_cell_migration0.63004284
90MP0009765_abnormal_xenobiotic_induced0.61990871
91MP0003329_amyloid_beta_deposits0.61900372
92MP0005165_increased_susceptibility_to0.60925705
93MP0002933_joint_inflammation0.60859399
94MP0008874_decreased_physiological_sensi0.57143673
95MP0000249_abnormal_blood_vessel0.54372868
96MP0005023_abnormal_wound_healing0.54144659
97MP0005076_abnormal_cell_differentiation0.52931095
98MP0005075_abnormal_melanosome_morpholog0.50028739
99MP0002396_abnormal_hematopoietic_system0.47032205
100MP0004808_abnormal_hematopoietic_stem0.46312790

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.53874240
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.53874240
3Abnormality of glycolipid metabolism (HP:0010969)6.53874240
4Abnormality of macrophages (HP:0004311)5.88213736
5Eczematoid dermatitis (HP:0000976)5.12706823
6Recurrent abscess formation (HP:0002722)5.09168554
7Recurrent bacterial skin infections (HP:0005406)5.01949596
8Loss of speech (HP:0002371)4.50165714
9Myositis (HP:0100614)4.41462279
10Increased cerebral lipofuscin (HP:0011813)4.34224360
11Systemic lupus erythematosus (HP:0002725)4.28269481
12Dysostosis multiplex (HP:0000943)4.27756082
13Recurrent gram-negative bacterial infections (HP:0005420)4.26059859
14Vacuolated lymphocytes (HP:0001922)4.24311328
15Stomatitis (HP:0010280)4.22692708
16Orchitis (HP:0100796)4.14915738
17Disinhibition (HP:0000734)4.14061505
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.94708650
19Optic neuritis (HP:0100653)3.92466694
20Retrobulbar optic neuritis (HP:0100654)3.92466694
21Mediastinal lymphadenopathy (HP:0100721)3.77971638
22Mutism (HP:0002300)3.66493092
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.54491401
24Obstructive lung disease (HP:0006536)3.38857557
25Chronic obstructive pulmonary disease (HP:0006510)3.38857557
26Abnormality of polysaccharide metabolism (HP:0011012)3.24578790
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24578790
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24578790
29Amyloidosis (HP:0011034)3.17805979
30Elevated erythrocyte sedimentation rate (HP:0003565)3.17608041
31Malnutrition (HP:0004395)3.03248504
32Spontaneous hematomas (HP:0007420)3.03077743
33Mucopolysacchariduria (HP:0008155)3.02050099
34Urinary glycosaminoglycan excretion (HP:0003541)3.02050099
35Purpura (HP:0000979)3.01795676
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.95891398
37Petechiae (HP:0000967)2.91534454
38Meningitis (HP:0001287)2.90503681
39Recurrent skin infections (HP:0001581)2.90455940
40Axonal loss (HP:0003447)2.86847512
41Recurrent fungal infections (HP:0002841)2.83092106
42Autoimmune thrombocytopenia (HP:0001973)2.81906085
43Neurofibrillary tangles (HP:0002185)2.78239460
44Increased serum ferritin (HP:0003281)2.76965181
45Diminished motivation (HP:0000745)2.73066378
46Apathy (HP:0000741)2.72096582
47Pulmonary infiltrates (HP:0002113)2.71856950
48Glomerulonephritis (HP:0000099)2.71302312
49Gingivitis (HP:0000230)2.67889534
50Urticaria (HP:0001025)2.64163674
51Nuclear cataract (HP:0100018)2.62955109
52Progressive neurologic deterioration (HP:0002344)2.62564916
53Keratoconjunctivitis sicca (HP:0001097)2.61813906
54Vasculitis (HP:0002633)2.60445701
55Hepatosplenomegaly (HP:0001433)2.48402897
56Agnosia (HP:0010524)2.48165323
57Hemoptysis (HP:0002105)2.47961102
58Neuronal loss in central nervous system (HP:0002529)2.45544863
59Hematochezia (HP:0002573)2.39736303
60Encephalitis (HP:0002383)2.38373938
61Keratoconjunctivitis (HP:0001096)2.38298714
62Cellulitis (HP:0100658)2.37253748
63Increased IgE level (HP:0003212)2.37214217
64Upper motor neuron abnormality (HP:0002127)2.33255959
65Episodic fever (HP:0001954)2.26059068
66Abnormality of iron homeostasis (HP:0011031)2.23825012
67Osteomyelitis (HP:0002754)2.21629735
68Inappropriate behavior (HP:0000719)2.20793749
69Conjunctival telangiectasia (HP:0000524)2.20583649
70Polyneuropathy (HP:0001271)2.16861022
71Metaphyseal irregularity (HP:0003025)2.14075336
72Prolonged bleeding time (HP:0003010)2.14017409
73Pustule (HP:0200039)2.09319099
74Increased IgM level (HP:0003496)2.08918475
75Pulmonary embolism (HP:0002204)2.07989063
76Recurrent viral infections (HP:0004429)2.07707332
77Gastrointestinal infarctions (HP:0005244)2.06694181
78Memory impairment (HP:0002354)2.06360667
79Complement deficiency (HP:0004431)2.02040215
80Basal ganglia calcification (HP:0002135)2.01325720
81T lymphocytopenia (HP:0005403)2.01250754
82Inflammation of the large intestine (HP:0002037)1.99425578
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99167419
84Recurrent cutaneous fungal infections (HP:0011370)1.96762711
85Chronic mucocutaneous candidiasis (HP:0002728)1.96762711
86Epistaxis (HP:0000421)1.95242501
87Dementia (HP:0000726)1.94879331
88Recurrent pneumonia (HP:0006532)1.94109856
89Prolonged neonatal jaundice (HP:0006579)1.93533344
90Gastrointestinal inflammation (HP:0004386)1.92243160
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.92015325
92Anorexia (HP:0002039)1.91839776
93Supranuclear gaze palsy (HP:0000605)1.89670077
94Gangrene (HP:0100758)1.87668948
95Pathologic fracture (HP:0002756)1.86902035
96Premature loss of primary teeth (HP:0006323)1.86624257
97Personality changes (HP:0000751)1.86563531
98Abnormality of complement system (HP:0005339)1.86383882
99Leukocytosis (HP:0001974)1.86213858
100Cerebral inclusion bodies (HP:0100314)1.86178701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.76476185
2MAP4K13.13643670
3BLK3.04314164
4MAP3K132.89944979
5ERN12.81883032
6IRAK42.71808607
7TYK22.47990569
8CSK2.42363390
9MAP2K32.40035607
10TGFBR22.23756959
11ARAF2.22992696
12MAP3K112.21439742
13TBK12.20976635
14IRAK32.17956501
15MAP3K142.17675303
16TNK22.17603155
17NME22.17278297
18MAP3K32.11871741
19TAOK21.94331958
20TAOK11.93427444
21FES1.92693658
22FGR1.87627213
23ZAP701.82330758
24PRPF4B1.73641410
25MATK1.72942725
26MOS1.71325831
27CSF1R1.70107143
28GRK71.68297471
29IKBKB1.63986648
30JAK31.60820527
31IKBKE1.57043254
32TXK1.49965052
33SYK1.46948524
34KIT1.36986220
35MAP3K91.35460172
36TESK21.33452996
37ACVR1B1.31023255
38LYN1.30342034
39TAOK31.28031208
40BTK1.26682810
41MAP3K11.26654082
42BMPR21.20423010
43HCK1.19444363
44GRK61.17757349
45MARK31.14474946
46LCK1.03547116
47CAMKK20.98751621
48BRAF0.94837165
49CDC42BPA0.93722900
50ABL20.93422861
51KSR20.87870386
52SIK30.87564980
53IRAK20.83648472
54JAK10.78591934
55STK100.76727119
56JAK20.75892136
57DDR20.74918152
58PDK10.74611834
59STK240.74140014
60MAP3K50.71835242
61PDPK10.69091618
62CAMK1D0.68095807
63TESK10.63139641
64PRKD20.62009236
65TEC0.61002895
66EPHB10.60894234
67RIPK10.60342787
68MARK20.59329613
69IRAK10.56055087
70PIM10.55819358
71ITK0.55647083
72CHUK0.55331609
73PIM20.54048899
74CDK190.52348668
75MAP3K80.50106664
76FYN0.46393505
77LRRK20.46356327
78MAPK120.43846575
79MAPK70.43778241
80TGFBR10.41385679
81MAP2K60.40772448
82RPS6KL10.38197550
83RPS6KC10.38197550
84SIK20.38105903
85MAPK40.35818354
86PRKCQ0.35566461
87MAP3K60.35536382
88CDK90.33383215
89ABL10.32070608
90DAPK20.30397486
91PRKG20.30077988
92KSR10.29785028
93TRIB30.27523924
94RPS6KA60.27315749
95CAMKK10.25972503
96RAF10.25649433
97PAK10.24632055
98MAPKAPK20.24344203
99RPS6KA20.24097398
100PRKCD0.23250554

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.26465828
2Other glycan degradation_Homo sapiens_hsa005113.25638119
3Osteoclast differentiation_Homo sapiens_hsa043803.10524981
4Leishmaniasis_Homo sapiens_hsa051402.82387462
5Lysosome_Homo sapiens_hsa041422.69465261
6Allograft rejection_Homo sapiens_hsa053302.64933584
7Graft-versus-host disease_Homo sapiens_hsa053322.44755103
8Asthma_Homo sapiens_hsa053102.42785712
9Rheumatoid arthritis_Homo sapiens_hsa053232.40940132
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35788803
11Autoimmune thyroid disease_Homo sapiens_hsa053202.32809129
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.28399406
13Tuberculosis_Homo sapiens_hsa051522.25977282
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.10000862
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00819608
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96924972
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92018813
18Malaria_Homo sapiens_hsa051441.91833845
19Antigen processing and presentation_Homo sapiens_hsa046121.88897875
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.87177817
21Type I diabetes mellitus_Homo sapiens_hsa049401.82161387
22Phagosome_Homo sapiens_hsa041451.80817469
23Pertussis_Homo sapiens_hsa051331.76397757
24B cell receptor signaling pathway_Homo sapiens_hsa046621.72510198
25Legionellosis_Homo sapiens_hsa051341.66751412
26Hematopoietic cell lineage_Homo sapiens_hsa046401.60256866
27Toxoplasmosis_Homo sapiens_hsa051451.55992477
28TNF signaling pathway_Homo sapiens_hsa046681.53627928
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53386278
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48124884
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45571238
32Salmonella infection_Homo sapiens_hsa051321.45549962
33Viral myocarditis_Homo sapiens_hsa054161.42666291
34Influenza A_Homo sapiens_hsa051641.40536785
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40304973
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32686353
37Primary immunodeficiency_Homo sapiens_hsa053401.31407528
38Herpes simplex infection_Homo sapiens_hsa051681.30573696
39Chemokine signaling pathway_Homo sapiens_hsa040621.28207336
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19084033
41Acute myeloid leukemia_Homo sapiens_hsa052211.17912525
42African trypanosomiasis_Homo sapiens_hsa051431.17853592
43Collecting duct acid secretion_Homo sapiens_hsa049661.16074934
44Measles_Homo sapiens_hsa051621.15377612
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13930826
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11337179
47Shigellosis_Homo sapiens_hsa051311.08845838
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08442716
49T cell receptor signaling pathway_Homo sapiens_hsa046601.04342034
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02865908
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96035251
52Prion diseases_Homo sapiens_hsa050200.85196622
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.84801780
54Hepatitis B_Homo sapiens_hsa051610.84357144
55Hepatitis C_Homo sapiens_hsa051600.79237879
56Apoptosis_Homo sapiens_hsa042100.78339741
57Amoebiasis_Homo sapiens_hsa051460.75719678
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.75596084
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.74585578
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72153773
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69335565
62Epstein-Barr virus infection_Homo sapiens_hsa051690.66450789
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66421425
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65326584
65Platelet activation_Homo sapiens_hsa046110.64525869
66Endocytosis_Homo sapiens_hsa041440.59071972
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58807812
68VEGF signaling pathway_Homo sapiens_hsa043700.56232827
69Vibrio cholerae infection_Homo sapiens_hsa051100.55878841
70Complement and coagulation cascades_Homo sapiens_hsa046100.55242629
71Sphingolipid metabolism_Homo sapiens_hsa006000.54598172
72Bladder cancer_Homo sapiens_hsa052190.50478043
73HTLV-I infection_Homo sapiens_hsa051660.48612851
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.48157981
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.46079827
76Pancreatic cancer_Homo sapiens_hsa052120.45875102
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41916422
78Prolactin signaling pathway_Homo sapiens_hsa049170.41213016
79Dorso-ventral axis formation_Homo sapiens_hsa043200.38821046
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.38482802
81Non-small cell lung cancer_Homo sapiens_hsa052230.37368021
82Viral carcinogenesis_Homo sapiens_hsa052030.35553081
83HIF-1 signaling pathway_Homo sapiens_hsa040660.34011063
84Chronic myeloid leukemia_Homo sapiens_hsa052200.33701415
85Notch signaling pathway_Homo sapiens_hsa043300.33461353
86Renal cell carcinoma_Homo sapiens_hsa052110.32348324
87Galactose metabolism_Homo sapiens_hsa000520.32292794
88Synaptic vesicle cycle_Homo sapiens_hsa047210.31685266
89Mineral absorption_Homo sapiens_hsa049780.31394157
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31056889
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30828035
92Regulation of autophagy_Homo sapiens_hsa041400.27479777
93FoxO signaling pathway_Homo sapiens_hsa040680.27392638
94Ovarian steroidogenesis_Homo sapiens_hsa049130.25805072
95MAPK signaling pathway_Homo sapiens_hsa040100.24626152
96mTOR signaling pathway_Homo sapiens_hsa041500.21703564
97GnRH signaling pathway_Homo sapiens_hsa049120.21557111
98Type II diabetes mellitus_Homo sapiens_hsa049300.17652277
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16345020
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.13286637

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »