TNFSF13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.11228929
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.62178349
3regulation of spindle organization (GO:0090224)5.39952650
4metaphase plate congression (GO:0051310)5.31573864
5negative regulation of cell killing (GO:0031342)5.14834766
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.14834766
7purine nucleobase biosynthetic process (GO:0009113)4.99793306
8DNA replication checkpoint (GO:0000076)4.88445898
9neutrophil activation involved in immune response (GO:0002283)4.77748527
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72196372
11regulation of exit from mitosis (GO:0007096)4.61293810
12monoubiquitinated protein deubiquitination (GO:0035520)4.55524040
13establishment of chromosome localization (GO:0051303)4.52577407
14attachment of spindle microtubules to kinetochore (GO:0008608)4.46717607
15protein localization to kinetochore (GO:0034501)4.46384796
16vitamin transmembrane transport (GO:0035461)4.33049045
17regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.18076742
18protein K6-linked ubiquitination (GO:0085020)4.15849668
19positive regulation of gamma-delta T cell activation (GO:0046645)4.13112749
20positive regulation of chromosome segregation (GO:0051984)4.11862572
21nucleobase biosynthetic process (GO:0046112)4.10715186
22protein localization to chromosome, centromeric region (GO:0071459)4.10581643
23rRNA modification (GO:0000154)4.08236141
24immunoglobulin mediated immune response (GO:0016064)4.02533047
25positive regulation of mast cell activation (GO:0033005)4.01252039
26oocyte maturation (GO:0001556)3.92254626
27folic acid transport (GO:0015884)3.90398202
28termination of RNA polymerase III transcription (GO:0006386)3.87050847
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.87050847
30positive regulation of defense response to virus by host (GO:0002230)3.83848168
31regulation of memory T cell differentiation (GO:0043380)3.83032333
32ribosome assembly (GO:0042255)3.82284979
33regulation of B cell receptor signaling pathway (GO:0050855)3.80326724
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79321316
35regulation of mitotic spindle organization (GO:0060236)3.78883100
36antigen processing and presentation of endogenous antigen (GO:0019883)3.77239430
37positive regulation of mast cell activation involved in immune response (GO:0033008)3.76033598
38positive regulation of mast cell degranulation (GO:0043306)3.76033598
39spindle checkpoint (GO:0031577)3.73887011
40interferon-gamma secretion (GO:0072643)3.68727815
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.67989573
427-methylguanosine mRNA capping (GO:0006370)3.67730536
43meiosis I (GO:0007127)3.66543346
44regulation of G0 to G1 transition (GO:0070316)3.65288419
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.64661843
46neutrophil activation (GO:0042119)3.64156225
47microglial cell activation (GO:0001774)3.62258795
48negative regulation of interleukin-12 production (GO:0032695)3.61712737
49RNA capping (GO:0036260)3.61388529
507-methylguanosine RNA capping (GO:0009452)3.61388529
51regulation of chromosome segregation (GO:0051983)3.61110583
52cellular response to exogenous dsRNA (GO:0071360)3.59441850
53maturation of 5.8S rRNA (GO:0000460)3.57052967
54termination of RNA polymerase I transcription (GO:0006363)3.56123797
55histone-serine phosphorylation (GO:0035404)3.55700908
56regulation of meiosis I (GO:0060631)3.53132219
57positive regulation by symbiont of host defense response (GO:0052509)3.52604436
58modulation by symbiont of host defense response (GO:0052031)3.52604436
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.52604436
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.52604436
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.52604436
62modulation by symbiont of host immune response (GO:0052553)3.52604436
63protein localization to chromosome (GO:0034502)3.52180358
64negative regulation of T cell mediated immunity (GO:0002710)3.50625578
65CENP-A containing nucleosome assembly (GO:0034080)3.50526632
66mitotic sister chromatid segregation (GO:0000070)3.49971760
67interferon-gamma-mediated signaling pathway (GO:0060333)3.47840410
68regulation of gamma-delta T cell activation (GO:0046643)3.46003753
69regulation of T cell mediated cytotoxicity (GO:0001914)3.44760716
70regulation of mast cell activation (GO:0033003)3.44715486
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.43149835
72histone H2A monoubiquitination (GO:0035518)3.40858053
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40562073
74regulation of interferon-alpha production (GO:0032647)3.40398968
75regulation of transcription from RNA polymerase I promoter (GO:0006356)3.39430750
76macrophage activation involved in immune response (GO:0002281)3.39426472
77positive regulation of interferon-alpha production (GO:0032727)3.37827021
78rRNA methylation (GO:0031167)3.37664902
79transcription from RNA polymerase I promoter (GO:0006360)3.35527513
80microtubule depolymerization (GO:0007019)3.35224061
81cellular response to interleukin-15 (GO:0071350)3.33889443
82meiotic chromosome segregation (GO:0045132)3.33674356
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33378005
84mitotic chromosome condensation (GO:0007076)3.32460480
85DNA damage response, signal transduction resulting in transcription (GO:0042772)3.30214608
86granulocyte activation (GO:0036230)3.29740120
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29675601
88positive regulation of antigen processing and presentation (GO:0002579)3.28603706
89positive regulation of interleukin-17 production (GO:0032740)3.28117824
90transcription elongation from RNA polymerase II promoter (GO:0006368)3.25898260
91response to type I interferon (GO:0034340)3.24638698
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24580742
93cellular response to type I interferon (GO:0071357)3.24478091
94type I interferon signaling pathway (GO:0060337)3.24478091
95interferon-gamma production (GO:0032609)3.24389927
96chromatin remodeling at centromere (GO:0031055)3.24188983
97antigen processing and presentation via MHC class Ib (GO:0002475)3.24182603
98positive regulation of T-helper 1 type immune response (GO:0002827)3.23384911
99positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22947727
100sphingosine metabolic process (GO:0006670)3.22375051
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22117622
102regulation of mitotic spindle checkpoint (GO:1903504)3.22117622
103cellular extravasation (GO:0045123)3.22084712
104inner cell mass cell proliferation (GO:0001833)3.21712168
105male meiosis I (GO:0007141)3.21626848
106folic acid metabolic process (GO:0046655)3.21583496
107histone exchange (GO:0043486)3.21450291
108regulation of mast cell degranulation (GO:0043304)3.21291108
109negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21121760
110transcription initiation from RNA polymerase I promoter (GO:0006361)3.20296510
111myeloid cell activation involved in immune response (GO:0002275)3.20067696
112ribosome biogenesis (GO:0042254)3.19904936
113mast cell activation (GO:0045576)3.18972028
114B cell mediated immunity (GO:0019724)3.18224187
115regulation of regulatory T cell differentiation (GO:0045589)3.18220327
116DNA-templated transcription, elongation (GO:0006354)3.17829414
117response to interferon-beta (GO:0035456)3.16784902
118neutrophil mediated immunity (GO:0002446)3.15701233
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14785873
120negative regulation of T-helper cell differentiation (GO:0045623)3.14785873
121mitotic spindle checkpoint (GO:0071174)3.14274221
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.12999315
123regulation of DNA methylation (GO:0044030)3.12639795
124chromosome segregation (GO:0007059)3.12288766
125negative regulation of lymphocyte mediated immunity (GO:0002707)3.11937330
126intestinal epithelial cell development (GO:0060576)3.11771026
127detection of molecule of bacterial origin (GO:0032490)3.10048866
128DNA replication-independent nucleosome assembly (GO:0006336)3.09665682
129DNA replication-independent nucleosome organization (GO:0034724)3.09665682
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09263127
131histone H2A ubiquitination (GO:0033522)3.08864367
132DNA-dependent DNA replication (GO:0006261)3.08679888
133regulation of translation in response to stress (GO:0043555)3.07535867
134regulation of spindle checkpoint (GO:0090231)3.06338549
135regulation of antigen processing and presentation (GO:0002577)3.06000753
136regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05923920
137regulation of T-helper 1 type immune response (GO:0002825)3.04429659
138regulation of RIG-I signaling pathway (GO:0039535)3.04269177
139regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03973026
140negative regulation of meiosis (GO:0045835)3.03082390
141response to interleukin-15 (GO:0070672)3.01946112
142mitotic nuclear envelope disassembly (GO:0007077)3.01366616
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.00920780
144DNA damage induced protein phosphorylation (GO:0006975)3.00734473
145regulation of gamma-delta T cell differentiation (GO:0045586)3.00479868
146regulation of mast cell activation involved in immune response (GO:0033006)2.99952756
147regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.99598543
148regulation of T-helper 1 cell differentiation (GO:0045625)2.99066938
149activated T cell proliferation (GO:0050798)2.97699678
150tolerance induction (GO:0002507)2.97576941
151regulation of sister chromatid cohesion (GO:0007063)2.96127544
152DNA deamination (GO:0045006)2.95967782
153detection of other organism (GO:0098543)2.95078661
154negative regulation of chromosome segregation (GO:0051985)2.95014560
155positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94673767
156positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94673767
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.94673767
158regulation of alpha-beta T cell proliferation (GO:0046640)2.93878354
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.93608144
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93608144
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93608144
162negative regulation of sister chromatid segregation (GO:0033046)2.93608144
163response to peptidoglycan (GO:0032494)2.92746069
164leukocyte degranulation (GO:0043299)2.92291493
165kinetochore assembly (GO:0051382)2.92185459
166regulation of leukocyte mediated cytotoxicity (GO:0001910)2.92136200
167negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91445686
168regulation of hypersensitivity (GO:0002883)2.90832282
169anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89438565
170regulation of establishment of cell polarity (GO:2000114)2.89420917
171negative regulation of DNA-templated transcription, elongation (GO:0032785)2.88710916
172negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88710916
173positive regulation of interferon-beta production (GO:0032728)2.88396401
174mitotic G2/M transition checkpoint (GO:0044818)2.88273185
175regulation of activation of Janus kinase activity (GO:0010533)2.88169443
176positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87900759
177regulation of T-helper cell differentiation (GO:0045622)2.87429861
178meiotic cell cycle process (GO:1903046)2.86679362
179positive regulation of Cdc42 GTPase activity (GO:0043089)2.86500181
180production of molecular mediator involved in inflammatory response (GO:0002532)2.84685505
181positive regulation of interleukin-12 production (GO:0032735)2.84508419
182diol metabolic process (GO:0034311)2.84483299
183regulation of meiosis (GO:0040020)2.84336598
184response to xenobiotic stimulus (GO:0009410)2.81783830
185regulation of interleukin-17 production (GO:0032660)2.81445577
186regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.80983852
187regulation of interleukin-12 production (GO:0032655)2.80696958
188macrophage activation (GO:0042116)2.80296084
189positive regulation of T-helper cell differentiation (GO:0045624)2.79438060
190detection of external biotic stimulus (GO:0098581)2.76211467
191regulation of interferon-beta biosynthetic process (GO:0045357)2.75273244
192detection of bacterium (GO:0016045)2.74851673
193regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.71859246
194regulation of interleukin-12 biosynthetic process (GO:0045075)2.71132976
195positive regulation of type 2 immune response (GO:0002830)2.71062223
196positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71045569
197myeloid leukocyte mediated immunity (GO:0002444)2.69808994
198response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69554520
199response to host immune response (GO:0052572)2.69554520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46985707
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.23010992
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.85251938
4FOXM1_23109430_ChIP-Seq_U2OS_Human5.79393973
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.95111854
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90927774
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74367707
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61545851
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41356532
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27464980
11AR_21909140_ChIP-Seq_LNCAP_Human3.25740616
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21269013
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.82940808
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.82644913
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79449492
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67954454
17RUNX_20019798_ChIP-Seq_JUKART_Human2.50714564
18* IRF8_21731497_ChIP-ChIP_J774_Mouse2.48646731
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.46196021
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39967221
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29313681
22SCL_19346495_ChIP-Seq_HPC-7_Human2.23382832
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.16610091
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15810808
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08229550
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03614962
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00095663
28VDR_23849224_ChIP-Seq_CD4+_Human1.98653466
29GATA1_22025678_ChIP-Seq_K562_Human1.97102981
30MYB_26560356_Chip-Seq_TH2_Human1.90978664
31VDR_24787735_ChIP-Seq_THP-1_Human1.88712809
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85352385
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84354544
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.81645130
35EZH2_22144423_ChIP-Seq_EOC_Human1.78972365
36GATA3_27048872_Chip-Seq_THYMUS_Human1.76167735
37GATA3_26560356_Chip-Seq_TH2_Human1.75242430
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.75059857
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.73336379
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.69052009
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67474193
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63705701
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.63062977
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61768715
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61305126
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59845613
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58883645
48GABP_19822575_ChIP-Seq_HepG2_Human1.58366393
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54652884
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52645428
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50434285
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50248676
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49610423
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.47843128
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47544162
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46980035
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46804550
58FOXP3_21729870_ChIP-Seq_TREG_Human1.45907698
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45583309
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45070940
61* SPI1_23547873_ChIP-Seq_NB4_Human1.44031787
62DCP1A_22483619_ChIP-Seq_HELA_Human1.42846284
63KDM5A_27292631_Chip-Seq_BREAST_Human1.41043393
64SPI1_23127762_ChIP-Seq_K562_Human1.40005901
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38471173
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37735358
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37684612
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37088804
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.36568749
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34793206
71VDR_24763502_ChIP-Seq_THP-1_Human1.34579442
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32404438
73IRF1_19129219_ChIP-ChIP_H3396_Human1.31723968
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29171445
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27993171
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25069111
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24981794
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24557640
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24191457
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.24188132
81SMRT_27268052_Chip-Seq_Bcells_Human1.23285522
82* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21919930
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21337071
84MYB_26560356_Chip-Seq_TH1_Human1.20785413
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19728275
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19495334
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19359161
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19095639
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15499595
90XRN2_22483619_ChIP-Seq_HELA_Human1.14339398
91* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14024220
92TAF15_26573619_Chip-Seq_HEK293_Human1.13639169
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13544574
94* SMAD_19615063_ChIP-ChIP_OVARY_Human1.11353838
95VDR_22108803_ChIP-Seq_LS180_Human1.11034617
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10431788
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09528180
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08270657
99GBX2_23144817_ChIP-Seq_PC3_Human1.07898720
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06055064
101ELK1_19687146_ChIP-ChIP_HELA_Human1.05639123
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04962738
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04654483
104* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02889120
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.02732433
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.02671222
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.98519055
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97658035
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96922507
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96917330
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96872856
112* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96861394
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96805508
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96725426
115* STAT1_20625510_ChIP-Seq_HELA_Human0.96380747
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.96371091
117UTX_26944678_Chip-Seq_JUKART_Human0.95717151
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95137864
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93417497
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93263752
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93061581
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92936344
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92387453
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91964013
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91764036
126MAF_26560356_Chip-Seq_TH1_Human0.91480782
127ER_23166858_ChIP-Seq_MCF-7_Human0.91195818
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.91166116
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90918016
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.90216569
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89180295
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88653600
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88509882
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.88509882
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87853236
136* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86716711
137ELK1_22589737_ChIP-Seq_MCF10A_Human0.85714398
138PU_27001747_Chip-Seq_BMDM_Mouse0.85568822
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84996818
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84885532
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84553970
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84383477
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83485179
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83176195
145TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82549698
146* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81637365
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81618690
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81273033
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.81190515
150GATA3_26560356_Chip-Seq_TH1_Human0.80898226
151BP1_19119308_ChIP-ChIP_Hs578T_Human0.80659694
152YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80571334
153NANOG_19829295_ChIP-Seq_ESCs_Human0.80559131
154SOX2_19829295_ChIP-Seq_ESCs_Human0.80559131
155SPI1_20517297_ChIP-Seq_HL60_Human0.80043661
156SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80027407
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79866740
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79300166
159TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78684216
160TTF2_22483619_ChIP-Seq_HELA_Human0.78310715
161* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78158085
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77846971
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77652339
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77249532
165POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77192892
166HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76227278
167LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75580100
168MYC_18940864_ChIP-ChIP_HL60_Human0.75348148
169* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75300977
170Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75047040
171POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74252831
172VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72374407
173BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71716175
174PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71152131
175SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71036292
176NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70986543
177PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70131982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.88735231
2MP0003718_maternal_effect4.13521694
3MP0003111_abnormal_nucleus_morphology3.95616477
4MP0008260_abnormal_autophagy3.47382273
5MP0005451_abnormal_body_composition3.28975031
6MP0010094_abnormal_chromosome_stability3.17384707
7MP0003077_abnormal_cell_cycle3.14976906
8MP0000685_abnormal_immune_system2.95154992
9MP0004957_abnormal_blastocyst_morpholog2.89275243
10MP0008057_abnormal_DNA_replication2.56118642
11MP0009333_abnormal_splenocyte_physiolog2.49150069
12MP0003123_paternal_imprinting2.21838928
13MP0009764_decreased_sensitivity_to2.12403243
14MP0002396_abnormal_hematopoietic_system2.09243506
15MP0003303_peritoneal_inflammation2.05862516
16MP0008058_abnormal_DNA_repair2.00359605
17MP0010307_abnormal_tumor_latency1.99687346
18MP0009840_abnormal_foam_cell1.94276329
19MP0002102_abnormal_ear_morphology1.93248982
20MP0008007_abnormal_cellular_replicative1.91858092
21MP0003436_decreased_susceptibility_to1.80733195
22MP0003763_abnormal_thymus_physiology1.79993144
23MP0002653_abnormal_ependyma_morphology1.77899326
24MP0002132_abnormal_respiratory_system1.77515208
25MP0002419_abnormal_innate_immunity1.75876601
26MP0000569_abnormal_digit_pigmentation1.72909363
27MP0005397_hematopoietic_system_phenotyp1.72826783
28MP0001545_abnormal_hematopoietic_system1.72826783
29MP0010155_abnormal_intestine_physiology1.67819961
30MP0005395_other_phenotype1.66856230
31MP0001730_embryonic_growth_arrest1.58875637
32MP0008932_abnormal_embryonic_tissue1.56782189
33MP0001835_abnormal_antigen_presentation1.55414365
34MP0005310_abnormal_salivary_gland1.54083930
35MP0008877_abnormal_DNA_methylation1.54079761
36MP0003724_increased_susceptibility_to1.53882331
37MP0005058_abnormal_lysosome_morphology1.51650062
38MP0003786_premature_aging1.49341807
39MP0002277_abnormal_respiratory_mucosa1.48901344
40MP0009785_altered_susceptibility_to1.44947757
41MP0000350_abnormal_cell_proliferation1.43624935
42MP0006292_abnormal_olfactory_placode1.43396408
43MP0002163_abnormal_gland_morphology1.40541761
44MP0008469_abnormal_protein_level1.39593227
45MP0003195_calcinosis1.35223843
46MP0001533_abnormal_skeleton_physiology1.32652118
47MP0004947_skin_inflammation1.32091532
48MP0000490_abnormal_crypts_of1.27618406
49MP0001119_abnormal_female_reproductive1.27359014
50MP0003656_abnormal_erythrocyte_physiolo1.26653202
51MP0003866_abnormal_defecation1.24718469
52MP0005025_abnormal_response_to1.23029180
53MP0001542_abnormal_bone_strength1.22504756
54MP0003646_muscle_fatigue1.22366375
55MP0005380_embryogenesis_phenotype1.20495701
56MP0001672_abnormal_embryogenesis/_devel1.20495701
57MP0002166_altered_tumor_susceptibility1.19036707
58MP0005075_abnormal_melanosome_morpholog1.18615288
59MP0005000_abnormal_immune_tolerance1.18387795
60MP0004782_abnormal_surfactant_physiolog1.18261925
61MP0003011_delayed_dark_adaptation1.17678502
62MP0003828_pulmonary_edema1.16419364
63* MP0002452_abnormal_antigen_presenting1.16383302
64MP0009278_abnormal_bone_marrow1.15870383
65MP0003191_abnormal_cellular_cholesterol1.15346317
66MP0005408_hypopigmentation1.14678089
67MP0001661_extended_life_span1.13696479
68MP0003448_altered_tumor_morphology1.13539169
69MP0001929_abnormal_gametogenesis1.12716237
70MP0002210_abnormal_sex_determination1.12342067
71MP0004885_abnormal_endolymph1.12051605
72MP0005167_abnormal_blood-brain_barrier1.11281061
73MP0002998_abnormal_bone_remodeling1.10920182
74MP0002405_respiratory_system_inflammati1.09910720
75MP0009765_abnormal_xenobiotic_induced1.07807471
76MP0005174_abnormal_tail_pigmentation1.07444114
77MP0002148_abnormal_hypersensitivity_rea1.06053646
78* MP0001819_abnormal_immune_cell1.05002794
79MP0003699_abnormal_female_reproductive1.04997684
80MP0000653_abnormal_sex_gland1.04810830
81* MP0002420_abnormal_adaptive_immunity1.03002278
82MP0003806_abnormal_nucleotide_metabolis1.02610442
83* MP0002723_abnormal_immune_serum1.00285845
84MP0001853_heart_inflammation1.00122689
85MP0008872_abnormal_physiological_respon0.99739215
86MP0001697_abnormal_embryo_size0.99169120
87MP0005646_abnormal_pituitary_gland0.98512191
88MP0003938_abnormal_ear_development0.97827960
89MP0000858_altered_metastatic_potential0.96462255
90MP0001986_abnormal_taste_sensitivity0.95676684
91MP0001845_abnormal_inflammatory_respons0.94854592
92MP0003984_embryonic_growth_retardation0.94781554
93MP0001145_abnormal_male_reproductive0.94587531
94MP0009763_increased_sensitivity_to0.94277351
95* MP0001800_abnormal_humoral_immune0.94022693
96MP0008004_abnormal_stomach_pH0.93613786
97MP0001851_eye_inflammation0.93338302
98MP0001765_abnormal_ion_homeostasis0.92978634
99MP0003638_abnormal_response/metabolism_0.92859746
100MP0005390_skeleton_phenotype0.92432111
101MP0000703_abnormal_thymus_morphology0.91328241
102MP0004142_abnormal_muscle_tone0.90972435
103MP0000627_abnormal_mammary_gland0.90923109
104* MP0000689_abnormal_spleen_morphology0.90417558
105MP0002138_abnormal_hepatobiliary_system0.90417334
106* MP0002398_abnormal_bone_marrow0.90170540
107MP0002019_abnormal_tumor_incidence0.89827129
108MP0002088_abnormal_embryonic_growth/wei0.89487917
109MP0002837_dystrophic_cardiac_calcinosis0.89271118
110* MP0000716_abnormal_immune_system0.89179771
111MP0003252_abnormal_bile_duct0.88309738
112MP0001663_abnormal_digestive_system0.87552809
113MP0001440_abnormal_grooming_behavior0.87024171
114MP0003879_abnormal_hair_cell0.87003951
115MP0002006_tumorigenesis0.86035861
116MP0005464_abnormal_platelet_physiology0.85331961
117MP0003075_altered_response_to0.85055597
118MP0004808_abnormal_hematopoietic_stem0.84514296
119MP0006082_CNS_inflammation0.84375162
120MP0000465_gastrointestinal_hemorrhage0.84230911
121MP0005389_reproductive_system_phenotype0.82950445
122MP0001919_abnormal_reproductive_system0.82286324
123* MP0002722_abnormal_immune_system0.81557009
124MP0002876_abnormal_thyroid_physiology0.81229735
125MP0000750_abnormal_muscle_regeneration0.80965286
126MP0005621_abnormal_cell_physiology0.80796369
127MP0004130_abnormal_muscle_cell0.80411125
128MP0002080_prenatal_lethality0.80181889
129MP0005076_abnormal_cell_differentiation0.80125831
130MP0003136_yellow_coat_color0.80078665
131* MP0002429_abnormal_blood_cell0.80058235
132MP0000313_abnormal_cell_death0.80014364
133MP0001764_abnormal_homeostasis0.78862527
134MP0000343_altered_response_to0.78237688
135MP0003221_abnormal_cardiomyocyte_apopto0.77880771
136MP0003300_gastrointestinal_ulcer0.77878284
137* MP0005671_abnormal_response_to0.77814340
138MP0001501_abnormal_sleep_pattern0.77012191
139MP0003172_abnormal_lysosome_physiology0.76979890
140MP0005387_immune_system_phenotype0.76706842
141MP0001790_abnormal_immune_system0.76706842
142MP0004883_abnormal_blood_vessel0.75205036
143MP0005166_decreased_susceptibility_to0.74926664
144MP0005084_abnormal_gallbladder_morpholo0.74191689
145MP0005164_abnormal_response_to0.73148662
146MP0004510_myositis0.71398943
147MP0000230_abnormal_systemic_arterial0.71303796
148MP0002693_abnormal_pancreas_physiology0.69002648
149MP0003183_abnormal_peptide_metabolism0.68512302
150MP0001485_abnormal_pinna_reflex0.67423979
151MP0001873_stomach_inflammation0.67207171
152MP0001968_abnormal_touch/_nociception0.63209574
153MP0002332_abnormal_exercise_endurance0.61550743
154MP0004145_abnormal_muscle_electrophysio0.61207396
155MP0006072_abnormal_retinal_apoptosis0.60880689
156MP0000249_abnormal_blood_vessel0.60552220

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.22569324
2Retrobulbar optic neuritis (HP:0100654)5.17381707
3Optic neuritis (HP:0100653)5.17381707
4Recurrent abscess formation (HP:0002722)4.97190137
5Myositis (HP:0100614)4.87397564
6Orchitis (HP:0100796)4.81531606
7Breast hypoplasia (HP:0003187)4.51894160
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.51137748
9Elevated erythrocyte sedimentation rate (HP:0003565)4.41724775
10Stomatitis (HP:0010280)4.39366014
11Impulsivity (HP:0100710)4.39022567
12Recurrent bacterial skin infections (HP:0005406)4.37324740
13Hyperglycinemia (HP:0002154)4.23301948
14Chromsome breakage (HP:0040012)4.19195582
15Eczematoid dermatitis (HP:0000976)4.04601704
16Pustule (HP:0200039)3.94397235
17Male infertility (HP:0003251)3.71339506
18Recurrent gram-negative bacterial infections (HP:0005420)3.69559281
19Keratoconjunctivitis (HP:0001096)3.68152489
20Keratoconjunctivitis sicca (HP:0001097)3.64479492
21Patellar aplasia (HP:0006443)3.54488211
22Hyperglycinuria (HP:0003108)3.53501130
23Aplasia/Hypoplasia of the patella (HP:0006498)3.45380351
24Encephalitis (HP:0002383)3.38883896
25Prostate neoplasm (HP:0100787)3.38289984
26Pulmonary infiltrates (HP:0002113)3.31570778
27IgG deficiency (HP:0004315)3.30291508
28Recurrent cutaneous fungal infections (HP:0011370)3.28135953
29Chronic mucocutaneous candidiasis (HP:0002728)3.28135953
30T lymphocytopenia (HP:0005403)3.27014496
31Ureteral duplication (HP:0000073)3.26783226
32Capillary hemangiomas (HP:0005306)3.26254049
33Abnormality of T cell number (HP:0011839)3.20083003
34Hemoptysis (HP:0002105)3.17925928
35Facial hemangioma (HP:0000329)3.16666986
36Rough bone trabeculation (HP:0100670)3.16203985
37Meckel diverticulum (HP:0002245)3.14156684
38Abnormality of the preputium (HP:0100587)3.12275928
39Gastrointestinal infarctions (HP:0005244)3.09688200
40Abolished electroretinogram (ERG) (HP:0000550)3.07220962
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.06587970
42Vasculitis (HP:0002633)3.06233789
43Chronic obstructive pulmonary disease (HP:0006510)3.02025615
44Obstructive lung disease (HP:0006536)3.02025615
45Meningitis (HP:0001287)3.01284687
46Carpal bone hypoplasia (HP:0001498)2.99888435
47Entropion (HP:0000621)2.90453006
48Abnormality of chromosome stability (HP:0003220)2.87312247
49Abnormality of T cells (HP:0002843)2.83185578
50Leukocytosis (HP:0001974)2.83181230
51Abnormality of the ileum (HP:0001549)2.79652940
52Oligodactyly (hands) (HP:0001180)2.78583247
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.71908486
54Abnormality of macrophages (HP:0004311)2.71651634
55Arterial thrombosis (HP:0004420)2.71412437
56Abnormality of eosinophils (HP:0001879)2.62089487
57Cerebral hypomyelination (HP:0006808)2.61699554
58Abnormality of liposaccharide metabolism (HP:0010968)2.61612662
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.61612662
60Abnormality of glycolipid metabolism (HP:0010969)2.61612662
61Abnormal spermatogenesis (HP:0008669)2.60467526
62Gangrene (HP:0100758)2.57137535
63Gingivitis (HP:0000230)2.57044206
64Systemic lupus erythematosus (HP:0002725)2.56781321
65Abnormality of the labia minora (HP:0012880)2.54814555
66Anorexia (HP:0002039)2.54273646
67Flat capital femoral epiphysis (HP:0003370)2.52888340
68Abnormality of glycine metabolism (HP:0010895)2.52010407
69Abnormality of serine family amino acid metabolism (HP:0010894)2.52010407
70Panhypogammaglobulinemia (HP:0003139)2.51549615
71Abnormality of T cell physiology (HP:0011840)2.51504863
72Prolonged bleeding time (HP:0003010)2.51192128
73Abnormality of lateral ventricle (HP:0030047)2.50892085
74Oligodactyly (HP:0012165)2.49991763
75Abnormal trabecular bone morphology (HP:0100671)2.49446324
76Bone marrow hypocellularity (HP:0005528)2.48791255
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46954963
78Azoospermia (HP:0000027)2.46738964
79Abnormality of the pleura (HP:0002103)2.44232171
80Eosinophilia (HP:0001880)2.44218321
81Vertigo (HP:0002321)2.43075920
82Severe combined immunodeficiency (HP:0004430)2.40553114
83Congenital stationary night blindness (HP:0007642)2.39287481
84Pulmonary embolism (HP:0002204)2.38365449
85Absent radius (HP:0003974)2.35446990
86Petechiae (HP:0000967)2.33917682
87Mutism (HP:0002300)2.32625059
88Osteolytic defects of the hand bones (HP:0009699)2.32559617
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.32559617
90Granulocytopenia (HP:0001913)2.30316887
91Breast aplasia (HP:0100783)2.29671469
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29375548
93Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27762309
94Abnormality of the anterior horn cell (HP:0006802)2.26275773
95Degeneration of anterior horn cells (HP:0002398)2.26275773
96Chest pain (HP:0100749)2.25711262
97Atrioventricular block (HP:0001678)2.25673481
98Ectopic kidney (HP:0000086)2.25610844
99Abnormality of B cell number (HP:0010975)2.25096779
100Abnormality of the umbilical cord (HP:0010881)2.23838544
101Polyneuropathy (HP:0001271)2.21345603
102Adrenal hypoplasia (HP:0000835)2.21216756
103Stomach cancer (HP:0012126)2.21071072
104Ventricular fibrillation (HP:0001663)2.19541218
105Clubbing of toes (HP:0100760)2.19499649
106Aplasia/Hypoplasia of the breasts (HP:0010311)2.18927187
107Myelodysplasia (HP:0002863)2.18914675
108Chronic otitis media (HP:0000389)2.18825242
109Spinal muscular atrophy (HP:0007269)2.18585806
110Small intestinal stenosis (HP:0012848)2.17993168
111Duodenal stenosis (HP:0100867)2.17993168
112Porencephaly (HP:0002132)2.17476546
1133-Methylglutaconic aciduria (HP:0003535)2.17211043
114Pancreatic fibrosis (HP:0100732)2.17061655
115Absent forearm bone (HP:0003953)2.16463329
116Aplasia involving forearm bones (HP:0009822)2.16463329
117Asplenia (HP:0001746)2.15344029
118Epistaxis (HP:0000421)2.14887504
119Abnormal rod and cone electroretinograms (HP:0008323)2.13559565
120Keratitis (HP:0000491)2.11311023
121Conjunctival hamartoma (HP:0100780)2.11147043
122Wrist flexion contracture (HP:0001239)2.10274546
123Recurrent skin infections (HP:0001581)2.09615671
124Gingival bleeding (HP:0000225)2.09055444
125Clumsiness (HP:0002312)2.08465213
126Hyperglycemia (HP:0003074)2.08396990
127Recurrent viral infections (HP:0004429)2.07165219
128Tracheoesophageal fistula (HP:0002575)2.06590579
129Stillbirth (HP:0003826)2.06047508
130Increased IgM level (HP:0003496)2.05567884
131Thyroiditis (HP:0100646)2.04406688
132Abnormality of serum amino acid levels (HP:0003112)2.04119833
133Secondary amenorrhea (HP:0000869)2.04044658
134Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03865691
135Urticaria (HP:0001025)2.03596183
136Recurrent bronchitis (HP:0002837)2.02218533
137Acute myeloid leukemia (HP:0004808)2.00707097
138Insulin-resistant diabetes mellitus (HP:0000831)2.00683179
139Recurrent fungal infections (HP:0002841)2.00666172
140Alveolar cell carcinoma (HP:0006519)2.00560813
141B lymphocytopenia (HP:0010976)1.99012642
142Episodic fever (HP:0001954)1.98567476
143Polycythemia (HP:0001901)1.98525050
144Spontaneous hematomas (HP:0007420)1.98488560
145Irregular epiphyses (HP:0010582)1.95570324
146Neoplasm of the tracheobronchial system (HP:0100552)1.95561291
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.95281628
148Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95058391
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94869333
150Hematochezia (HP:0002573)1.93950459
151Gout (HP:0001997)1.93866677
152Abnormality of the pericardium (HP:0001697)1.93326227
153Premature ovarian failure (HP:0008209)1.93303163
154Oral leukoplakia (HP:0002745)1.92464216
155Abnormality of the prostate (HP:0008775)1.92017339
156Microretrognathia (HP:0000308)1.90243012
157Glomerulonephritis (HP:0000099)1.90138167
158Paralysis (HP:0003470)1.90053603
159Horseshoe kidney (HP:0000085)1.89959461
160Death in infancy (HP:0001522)1.89539185
161Joint swelling (HP:0001386)1.89461812
162Agitation (HP:0000713)1.88921195
163Bundle branch block (HP:0011710)1.88506635
164Shawl scrotum (HP:0000049)1.87083775
165Conjunctival telangiectasia (HP:0000524)1.87029361
166Mediastinal lymphadenopathy (HP:0100721)1.86797551
167Congenital, generalized hypertrichosis (HP:0004540)1.86596239
168Enlarged penis (HP:0000040)1.86452686
169Adactyly (HP:0009776)1.85298182
170Pulmonary fibrosis (HP:0002206)1.85088638
171Abnormality of the phalanges of the 5th finger (HP:0004213)1.81796460
172Short thumb (HP:0009778)1.81308198
173Metabolic alkalosis (HP:0200114)1.81196858
174CNS hypomyelination (HP:0003429)1.80722207
175Autoimmune thrombocytopenia (HP:0001973)1.80343395
176Hemiplegia (HP:0002301)1.79524198
177Microglossia (HP:0000171)1.78607616
178Bone cyst (HP:0012062)1.77939541
179Glomerulopathy (HP:0100820)1.77409094
180Combined immunodeficiency (HP:0005387)1.75323058
181Decreased circulating renin level (HP:0003351)1.74875689
182Autoimmune hemolytic anemia (HP:0001890)1.74160472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.52817255
2WEE14.17379106
3PLK43.48783094
4BRSK23.24198420
5LATS22.89793070
6LATS12.83107703
7STK38L2.64525707
8NEK22.64178763
9KIT2.38016156
10STK32.30531454
11IKBKE2.27270688
12TLK12.25010040
13AKT32.24731188
14FES2.20508706
15GRK62.16326566
16IKBKB2.11410871
17MAP3K142.09721399
18BMPR22.09328265
19ADRBK22.05186780
20ARAF2.05050034
21PLK32.01451068
22PLK12.00147864
23ACVR1B1.95985706
24CSF1R1.95803134
25SYK1.95425583
26GRK71.85150199
27BRSK11.82118273
28CDC71.82046790
29EIF2AK11.80960998
30STK241.79971847
31SRPK11.79937521
32TTK1.74887812
33MATK1.74853966
34MKNK21.73537490
35NUAK11.72745578
36BTK1.70552628
37CCNB11.69046552
38JAK11.66240192
39LYN1.63547270
40BRAF1.62990763
41TBK11.60901332
42MAP4K21.51212827
43TNK21.45952670
44HCK1.43610579
45ITK1.34784568
46DYRK31.26852919
47CHEK21.26664236
48RAF11.26442673
49NME21.25185745
50AURKB1.24650759
51LCK1.23463060
52DYRK21.22321907
53BCKDK1.22140913
54MAP3K91.19150669
55PINK11.17498874
56TAOK31.15642189
57RPS6KA41.10954734
58KSR21.08603826
59IRAK41.08483997
60TXK1.07190339
61BLK1.03725866
62VRK11.03068927
63TAOK11.02488115
64TSSK60.97917530
65TYK20.95423897
66MELK0.92820478
67MKNK10.91803249
68RIPK40.91445444
69MAP3K60.91161967
70MAP3K80.91051268
71NEK10.90664334
72TRPM70.90019696
73IRAK30.89777763
74DAPK20.89423300
75EIF2AK20.88451811
76FRK0.88420238
77NEK90.88180283
78STK160.86947168
79GRK50.84510735
80STK100.82974610
81ABL20.82625640
82MAP2K20.82068214
83CDK70.79900578
84IRAK10.79738425
85PIK3CG0.79562736
86ALK0.78941747
87AURKA0.78537849
88CDK190.78218320
89CDK30.76008370
90CDK40.75335424
91PIM10.74760799
92PTK2B0.74343545
93PRKCQ0.73053957
94ZAK0.71553141
95MAP3K50.71529523
96OXSR10.69039653
97MAPK70.68988227
98PDK20.68081881
99STK40.67969769
100EIF2AK30.67732203
101MAP2K60.66248671
102MAP3K110.64953772
103RPS6KA60.64690911
104CHUK0.64334347
105ADRBK10.64193276
106CDK80.63936403
107EPHA30.63379006
108PDK30.63096295
109PDK40.63096295
110CHEK10.61887974
111MUSK0.59512792
112GRK10.58149060
113PIM20.56251790
114PRKAA10.55838847
115SGK20.55499039
116FYN0.55361236
117IGF1R0.55305677
118ABL10.55201588
119TEC0.55069340
120TIE10.54915888
121JAK30.54830891
122MAP4K10.53869679
123RPS6KA50.53716155
124TGFBR20.53712539
125RPS6KL10.51201131
126RPS6KC10.51201131
127MOS0.49165920
128MARK30.49022084
129STK380.48724346
130PDK10.48025683
131MAP3K30.47755835
132ZAP700.47315975
133PAK10.46199152
134KDR0.44776022
135FGR0.44081239
136CSK0.43860719
137HIPK20.42221475
138ATR0.41529313
139INSRR0.40770289
140PRKCD0.39373966
141CSNK1G10.39084271
142MAPK40.38981977
143MAP3K120.38858089
144MAP2K30.37380471
145PRKD20.36072431
146ATM0.34697748
147SGK30.34532703
148CDK20.34178148
149PRKAA20.34022190
150STK110.33845068
151MAP3K130.32573698
152ERBB40.32034022
153MAPK120.31998175
154CSNK1G30.31617440
155JAK20.31574786
156TESK20.31392443
157MST40.30913589
158CLK10.30881250
159MAPK30.30792047
160PKN10.30780756
161MAPK110.30440423
162NEK60.30341478
163PRKACG0.29758991
164EGFR0.29746132
165SIK20.28974010
166INSR0.28627733
167RPS6KA20.27868121
168BMPR1B0.27590683
169ERN10.27586116

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.83799484
2RNA polymerase_Homo sapiens_hsa030204.69880032
3Asthma_Homo sapiens_hsa053103.63898448
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46265312
5Cell cycle_Homo sapiens_hsa041103.22970322
6Type I diabetes mellitus_Homo sapiens_hsa049402.73672432
7Basal transcription factors_Homo sapiens_hsa030222.73411774
8RNA transport_Homo sapiens_hsa030132.57653945
9Primary immunodeficiency_Homo sapiens_hsa053402.44169595
10Pyrimidine metabolism_Homo sapiens_hsa002402.20341480
11Homologous recombination_Homo sapiens_hsa034402.15744150
12Regulation of autophagy_Homo sapiens_hsa041402.15346069
13p53 signaling pathway_Homo sapiens_hsa041151.98881150
14Fanconi anemia pathway_Homo sapiens_hsa034601.94230927
15Pentose phosphate pathway_Homo sapiens_hsa000301.92653598
16DNA replication_Homo sapiens_hsa030301.79091901
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77625066
18Proteasome_Homo sapiens_hsa030501.69539355
19Staphylococcus aureus infection_Homo sapiens_hsa051501.69501915
20Purine metabolism_Homo sapiens_hsa002301.64718677
21Base excision repair_Homo sapiens_hsa034101.58024273
22* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56195264
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53438735
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.50610458
25Folate biosynthesis_Homo sapiens_hsa007901.45072879
26Vitamin digestion and absorption_Homo sapiens_hsa049771.44653672
27Viral myocarditis_Homo sapiens_hsa054161.42809517
28Nucleotide excision repair_Homo sapiens_hsa034201.39598795
29Circadian rhythm_Homo sapiens_hsa047101.36485896
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31827302
31RNA degradation_Homo sapiens_hsa030181.31488263
32Oocyte meiosis_Homo sapiens_hsa041141.30102083
33B cell receptor signaling pathway_Homo sapiens_hsa046621.29083001
34Epstein-Barr virus infection_Homo sapiens_hsa051691.26330643
35Spliceosome_Homo sapiens_hsa030401.25899643
36African trypanosomiasis_Homo sapiens_hsa051431.25272284
37Other glycan degradation_Homo sapiens_hsa005111.24208246
38Herpes simplex infection_Homo sapiens_hsa051681.20915075
39Sphingolipid metabolism_Homo sapiens_hsa006001.13493743
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10286917
41Systemic lupus erythematosus_Homo sapiens_hsa053221.09176371
42Mismatch repair_Homo sapiens_hsa034301.07878723
43T cell receptor signaling pathway_Homo sapiens_hsa046601.05327408
44Leishmaniasis_Homo sapiens_hsa051401.02480932
45Lysosome_Homo sapiens_hsa041421.00153733
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97727684
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95503144
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90587025
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88793642
50Arachidonic acid metabolism_Homo sapiens_hsa005900.86310079
51mRNA surveillance pathway_Homo sapiens_hsa030150.83679806
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.82678333
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81291409
54Tuberculosis_Homo sapiens_hsa051520.80317757
55Platelet activation_Homo sapiens_hsa046110.79705763
56Collecting duct acid secretion_Homo sapiens_hsa049660.78479084
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77952459
58Antigen processing and presentation_Homo sapiens_hsa046120.75880194
59Phototransduction_Homo sapiens_hsa047440.75249432
60Nitrogen metabolism_Homo sapiens_hsa009100.75047540
61Oxidative phosphorylation_Homo sapiens_hsa001900.74123271
62Pancreatic cancer_Homo sapiens_hsa052120.72010691
63FoxO signaling pathway_Homo sapiens_hsa040680.71422472
64Sulfur metabolism_Homo sapiens_hsa009200.71334182
65Influenza A_Homo sapiens_hsa051640.70906951
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70745185
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68675975
68Morphine addiction_Homo sapiens_hsa050320.68667484
69Hepatitis B_Homo sapiens_hsa051610.68473138
70Measles_Homo sapiens_hsa051620.65926889
71Hepatitis C_Homo sapiens_hsa051600.65231195
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65210068
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64232918
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63248857
75Tryptophan metabolism_Homo sapiens_hsa003800.63166715
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62933049
77Olfactory transduction_Homo sapiens_hsa047400.60999377
78Apoptosis_Homo sapiens_hsa042100.59812209
79Non-homologous end-joining_Homo sapiens_hsa034500.59756441
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58307210
81* NF-kappa B signaling pathway_Homo sapiens_hsa040640.55198003
82Osteoclast differentiation_Homo sapiens_hsa043800.53868788
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.53430086
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52745249
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52272124
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51715797
87Mineral absorption_Homo sapiens_hsa049780.50428175
88Ether lipid metabolism_Homo sapiens_hsa005650.50241045
89Pertussis_Homo sapiens_hsa051330.50235639
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49551958
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.47648835
92Legionellosis_Homo sapiens_hsa051340.46121928
93Linoleic acid metabolism_Homo sapiens_hsa005910.45783843
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44156428
95Prolactin signaling pathway_Homo sapiens_hsa049170.44150521
96Salmonella infection_Homo sapiens_hsa051320.43432231
97Inositol phosphate metabolism_Homo sapiens_hsa005620.43250503
98Serotonergic synapse_Homo sapiens_hsa047260.42771356
99Allograft rejection_Homo sapiens_hsa053300.41429189
100* Intestinal immune network for IgA production_Homo sapiens_hsa046720.41173733
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41169661
102Renal cell carcinoma_Homo sapiens_hsa052110.40878433
103TGF-beta signaling pathway_Homo sapiens_hsa043500.40511540
104Graft-versus-host disease_Homo sapiens_hsa053320.40366852
105Shigellosis_Homo sapiens_hsa051310.39703056
106Parkinsons disease_Homo sapiens_hsa050120.38900933
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38802768
108Chemokine signaling pathway_Homo sapiens_hsa040620.38645888
109Chemical carcinogenesis_Homo sapiens_hsa052040.36973183
110Renin secretion_Homo sapiens_hsa049240.36759296
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36573894
112Hematopoietic cell lineage_Homo sapiens_hsa046400.36317049
113Small cell lung cancer_Homo sapiens_hsa052220.35371981
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.35314186
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.35289983
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35209944
117Ovarian steroidogenesis_Homo sapiens_hsa049130.35123456
118* Rheumatoid arthritis_Homo sapiens_hsa053230.35063559
119MicroRNAs in cancer_Homo sapiens_hsa052060.35018356
120Phagosome_Homo sapiens_hsa041450.34984662
121Viral carcinogenesis_Homo sapiens_hsa052030.34933104
122Autoimmune thyroid disease_Homo sapiens_hsa053200.34730172
123mTOR signaling pathway_Homo sapiens_hsa041500.34692149
124Malaria_Homo sapiens_hsa051440.34584466
125Caffeine metabolism_Homo sapiens_hsa002320.33983301
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.33507694
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32467815
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.32392140
129Dorso-ventral axis formation_Homo sapiens_hsa043200.32296673
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30496134
131Arginine and proline metabolism_Homo sapiens_hsa003300.30430377
132Toxoplasmosis_Homo sapiens_hsa051450.29947494
133TNF signaling pathway_Homo sapiens_hsa046680.29793067
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29726241
135Choline metabolism in cancer_Homo sapiens_hsa052310.29563636
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29345488
137Type II diabetes mellitus_Homo sapiens_hsa049300.28737358
138Cholinergic synapse_Homo sapiens_hsa047250.28668567
139Alzheimers disease_Homo sapiens_hsa050100.28629015
140Fructose and mannose metabolism_Homo sapiens_hsa000510.28014462
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27590162
142Prostate cancer_Homo sapiens_hsa052150.27191027
143MAPK signaling pathway_Homo sapiens_hsa040100.26985399
144HTLV-I infection_Homo sapiens_hsa051660.26936328
145Retinol metabolism_Homo sapiens_hsa008300.26899878
146Gastric acid secretion_Homo sapiens_hsa049710.24695466
147Salivary secretion_Homo sapiens_hsa049700.22665284
148Acute myeloid leukemia_Homo sapiens_hsa052210.22077912
149Renin-angiotensin system_Homo sapiens_hsa046140.21661319
150Glycerolipid metabolism_Homo sapiens_hsa005610.19285587
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18224979
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18120762
153Circadian entrainment_Homo sapiens_hsa047130.17237437

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