TNFSF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of monocyte differentiation (GO:0045655)6.03744334
2regulation of T-helper 1 cell differentiation (GO:0045625)5.97320500
3osteoclast differentiation (GO:0030316)5.82383019
4regulation of vitamin D biosynthetic process (GO:0060556)5.55435590
5oligosaccharide catabolic process (GO:0009313)5.35452562
6neutrophil activation involved in immune response (GO:0002283)5.26098333
7regulation of activation of Janus kinase activity (GO:0010533)5.23154680
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21011421
9response to peptidoglycan (GO:0032494)5.11759110
10positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.97589826
11positive regulation of interferon-alpha production (GO:0032727)4.92562060
12positive regulation of type 2 immune response (GO:0002830)4.88389233
13glycosphingolipid catabolic process (GO:0046479)4.76737925
14positive regulation of osteoclast differentiation (GO:0045672)4.65277103
15lipopolysaccharide-mediated signaling pathway (GO:0031663)4.62612248
16regulation of interferon-alpha production (GO:0032647)4.62316586
17regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.47895153
18regulation of vitamin metabolic process (GO:0030656)4.46188227
19hydrogen peroxide biosynthetic process (GO:0050665)4.43520569
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.39955745
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.39955745
22modulation by symbiont of host immune response (GO:0052553)4.39955745
23positive regulation by symbiont of host defense response (GO:0052509)4.39955745
24modulation by symbiont of host defense response (GO:0052031)4.39955745
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.39955745
26positive regulation of macrophage differentiation (GO:0045651)4.37546996
27cellular response to exogenous dsRNA (GO:0071360)4.36953294
28positive regulation of T-helper cell differentiation (GO:0045624)4.32017598
29glycolipid catabolic process (GO:0019377)4.29716928
30negative regulation of interleukin-17 production (GO:0032700)4.26346030
31granulocyte activation (GO:0036230)4.24064554
32positive regulation of bone resorption (GO:0045780)4.23985647
33positive regulation of bone remodeling (GO:0046852)4.23985647
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.22423898
35eosinophil chemotaxis (GO:0048245)4.22395650
36positive regulation of chemokine biosynthetic process (GO:0045080)4.17038934
37type I interferon signaling pathway (GO:0060337)4.16307114
38cellular response to type I interferon (GO:0071357)4.16307114
39negative regulation of viral genome replication (GO:0045071)4.12136209
40response to type I interferon (GO:0034340)4.11098354
41cellular response to interferon-beta (GO:0035458)4.09089146
42positive regulation of natural killer cell differentiation (GO:0032825)4.05482424
43superoxide anion generation (GO:0042554)4.03505165
44T-helper 1 type immune response (GO:0042088)4.03353491
45positive regulation of interleukin-12 production (GO:0032735)4.02155721
46respiratory burst (GO:0045730)3.99193502
47positive regulation of NF-kappaB import into nucleus (GO:0042346)3.99123932
48positive regulation of T cell chemotaxis (GO:0010820)3.98073020
49regulation of T cell chemotaxis (GO:0010819)3.98073020
50cellular response to interferon-alpha (GO:0035457)3.96552445
51natural killer cell mediated cytotoxicity (GO:0042267)3.95104949
52natural killer cell mediated immunity (GO:0002228)3.95104949
53regulation of immunoglobulin secretion (GO:0051023)3.93094167
54positive regulation of T cell cytokine production (GO:0002726)3.92046281
55reactive oxygen species biosynthetic process (GO:1903409)3.91411968
56ceramide catabolic process (GO:0046514)3.89515699
57neutrophil activation (GO:0042119)3.87206517
58regulation of T-helper cell differentiation (GO:0045622)3.86155395
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.85637529
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85062421
61regulation of chemokine biosynthetic process (GO:0045073)3.84271854
62negative regulation of lipid storage (GO:0010888)3.83538724
63production of molecular mediator involved in inflammatory response (GO:0002532)3.82647963
64eosinophil migration (GO:0072677)3.77606312
65regulation of mononuclear cell migration (GO:0071675)3.77180214
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.77004796
67regulation of T-helper 2 cell differentiation (GO:0045628)3.76403179
68positive regulation of odontogenesis (GO:0042482)3.72895635
69positive regulation of monocyte chemotaxis (GO:0090026)3.72464746
70positive regulation of interleukin-17 production (GO:0032740)3.72432538
71monocyte chemotaxis (GO:0002548)3.70853511
72regulation of interleukin-17 production (GO:0032660)3.68248351
73regulation of memory T cell differentiation (GO:0043380)3.66682946
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.63957257
75response to interferon-alpha (GO:0035455)3.63349480
76myeloid dendritic cell activation (GO:0001773)3.62208293
77positive regulation of heat generation (GO:0031652)3.60602705
78regulation of interferon-gamma biosynthetic process (GO:0045072)3.59682188
79regulation of fever generation (GO:0031620)3.58832986
80regulation of RIG-I signaling pathway (GO:0039535)3.58578506
81positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.57458006
82cellular response to zinc ion (GO:0071294)3.57308948
83positive regulation of cellular amide metabolic process (GO:0034250)3.56837075
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.56007784
85immunoglobulin mediated immune response (GO:0016064)3.55443416
86regulation of T-helper 1 type immune response (GO:0002825)3.54867303
87defense response to protozoan (GO:0042832)3.51053206
88cellular response to virus (GO:0098586)3.48486560
89positive regulation of tissue remodeling (GO:0034105)3.48326285
90positive regulation of interferon-beta production (GO:0032728)3.48037706
91regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.47606414
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.46334325
93response to muramyl dipeptide (GO:0032495)3.43232312
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.43058029
95regulation of alpha-beta T cell proliferation (GO:0046640)3.42212453
96regulation of macrophage differentiation (GO:0045649)3.41014778
97regulation of cholesterol storage (GO:0010885)3.39093012
98positive regulation of myeloid leukocyte differentiation (GO:0002763)3.37164101
99macrophage activation involved in immune response (GO:0002281)3.35550223
100decidualization (GO:0046697)3.34780575
101negative regulation of interleukin-12 production (GO:0032695)3.33903007
102response to host immune response (GO:0052572)3.27195577
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27195577
104regulation of heat generation (GO:0031650)3.26529433
105regulation of chronic inflammatory response (GO:0002676)3.26265582
106positive regulation of interleukin-10 production (GO:0032733)3.25213353
107positive regulation of lymphocyte migration (GO:2000403)3.24105332
108response to interferon-beta (GO:0035456)3.23773576
109regulation of membrane protein ectodomain proteolysis (GO:0051043)3.23502709
110positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.22072837
111positive regulation of interleukin-6 production (GO:0032755)3.21142863
112detection of molecule of bacterial origin (GO:0032490)3.19627446
113positive regulation of extracellular matrix organization (GO:1903055)3.19189710
114regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.17960510
115negative regulation of nitric oxide biosynthetic process (GO:0045019)3.16941939
116positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.16388001
117regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.16388001
118regulation of lymphocyte chemotaxis (GO:1901623)3.15485113
119regulation of T cell cytokine production (GO:0002724)3.15192854
120regulation of interleukin-12 production (GO:0032655)3.14573395
121pyrimidine-containing compound transmembrane transport (GO:0072531)3.14501897
122positive regulation of interleukin-2 production (GO:0032743)3.14423699
123regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.14079521
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13167777
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12554355
126cell adhesion mediated by integrin (GO:0033627)3.12199945
127interferon-gamma-mediated signaling pathway (GO:0060333)3.11902365
128regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11697645
129myeloid dendritic cell differentiation (GO:0043011)3.10992483
130response to lipoprotein particle (GO:0055094)3.09579583
131myeloid cell activation involved in immune response (GO:0002275)3.05940093
132positive regulation of mast cell activation involved in immune response (GO:0033008)3.02339845
133positive regulation of mast cell degranulation (GO:0043306)3.02339845
134positive regulation of T-helper 1 type immune response (GO:0002827)3.02199598
135regulation of podosome assembly (GO:0071801)3.01837403
136regulation of growth of symbiont in host (GO:0044126)3.01318298
137negative regulation of growth of symbiont in host (GO:0044130)3.01318298
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.01318298
139amino sugar catabolic process (GO:0046348)2.98113309
140regulation of NF-kappaB import into nucleus (GO:0042345)2.93332422
141dendritic cell differentiation (GO:0097028)2.92857617
142positive regulation of astrocyte differentiation (GO:0048711)2.91816585
143negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.91068096
144regulation of macrophage derived foam cell differentiation (GO:0010743)2.90839567
145positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.90641508
146cellular response to thyroid hormone stimulus (GO:0097067)2.89034125
147sphingolipid catabolic process (GO:0030149)2.86718006
148positive regulation of leukocyte degranulation (GO:0043302)2.85790039
149regulation of nitric oxide biosynthetic process (GO:0045428)2.84937865
150regulation of prostaglandin secretion (GO:0032306)2.84896661
151membrane lipid catabolic process (GO:0046466)2.84796165
152positive regulation of mast cell activation (GO:0033005)2.84656429
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81222995
154positive regulation of nitric oxide biosynthetic process (GO:0045429)2.77313119
155wound healing, spreading of epidermal cells (GO:0035313)2.72017532
156positive regulation of transcription factor import into nucleus (GO:0042993)2.70251229
157germinal center formation (GO:0002467)2.68353532
158regulation of lymphocyte migration (GO:2000401)2.68176647
159positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66686820
160positive regulation of prostaglandin secretion (GO:0032308)2.64181217
161positive regulation of leukocyte chemotaxis (GO:0002690)2.63922587
162tryptophan catabolic process (GO:0006569)2.58787801
163indole-containing compound catabolic process (GO:0042436)2.58787801
164indolalkylamine catabolic process (GO:0046218)2.58787801
165negative regulation of mast cell activation (GO:0033004)2.58439329
166regulation of interleukin-6 production (GO:0032675)2.57978327
167neutrophil chemotaxis (GO:0030593)2.56146528
168negative regulation of monooxygenase activity (GO:0032769)2.55496766
169positive regulation of calcium ion import (GO:0090280)2.54783180
170response to protozoan (GO:0001562)2.53864337
171myeloid leukocyte activation (GO:0002274)2.52532337
172peptide catabolic process (GO:0043171)2.52409674
173cellular response to lipopolysaccharide (GO:0071222)2.52085555
174granulocyte chemotaxis (GO:0071621)2.51961306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.29597553
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.73590012
3IRF8_21731497_ChIP-ChIP_J774_Mouse7.51513606
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.23044657
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.89417664
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.15534339
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81869212
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.57909571
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.52291040
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.48979388
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22683804
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.93216550
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70429953
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61185944
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51286838
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44627287
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37992319
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20229272
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03810385
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.88579881
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86468471
22VDR_24787735_ChIP-Seq_THP-1_Human1.70767658
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61765944
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59704933
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57724375
26CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48937687
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48238330
28SPI1_23547873_ChIP-Seq_NB4_Human1.45659963
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.44506163
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.42678081
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41567233
32* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41128839
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39803567
34PU_27001747_Chip-Seq_BMDM_Mouse1.38155104
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.34909649
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34791033
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34791033
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33163171
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.30990151
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30094256
41PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28767106
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28588764
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26104118
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25237888
45CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21830018
46RUNX_20019798_ChIP-Seq_JUKART_Human1.21781102
47MYB_26560356_Chip-Seq_TH2_Human1.20629969
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19170997
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19170997
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19170997
51TP53_16413492_ChIP-PET_HCT116_Human1.17704790
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14483419
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13821088
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13413613
55GATA3_26560356_Chip-Seq_TH2_Human1.12462122
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12079071
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05846116
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05668057
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04790877
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04621687
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.04386988
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04232678
63VDR_24763502_ChIP-Seq_THP-1_Human1.01612862
64* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00856209
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99851856
66SOX2_20726797_ChIP-Seq_SW620_Human0.97750949
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96984210
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95232461
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93920504
70GATA1_19941826_ChIP-Seq_K562_Human0.93730677
71* TP63_23658742_ChIP-Seq_EP156T_Human0.93614239
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.93203505
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.93182012
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92842679
75GATA1_22025678_ChIP-Seq_K562_Human0.92563413
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89711700
77EGR1_19032775_ChIP-ChIP_M12_Human0.89521728
78TRIM28_21343339_ChIP-Seq_HEK293_Human0.89411795
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88433239
80MYB_26560356_Chip-Seq_TH1_Human0.88088732
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88057474
82SPI1_23127762_ChIP-Seq_K562_Human0.86627966
83RUNX1_22412390_ChIP-Seq_EML_Mouse0.86275708
84* GATA3_27048872_Chip-Seq_THYMUS_Human0.83658377
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83634088
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83144690
87SCL_19346495_ChIP-Seq_HPC-7_Human0.81892434
88TP53_18474530_ChIP-ChIP_U2OS_Human0.81884788
89STAT1_20625510_ChIP-Seq_HELA_Human0.81701529
90* UBF1/2_26484160_Chip-Seq_HMECs_Human0.81625630
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81614740
92ZNF274_21170338_ChIP-Seq_K562_Hela0.81571840
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79895774
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.79894518
95* CJUN_26792858_Chip-Seq_BT549_Human0.77949639
96* RXR_22158963_ChIP-Seq_LIVER_Mouse0.76951122
97MAF_26560356_Chip-Seq_TH1_Human0.76816152
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75692151
99* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75420667
100GATA2_19941826_ChIP-Seq_K562_Human0.75321389
101PU1_27457419_Chip-Seq_LIVER_Mouse0.74845868
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74633706
103CMYC_18555785_Chip-Seq_ESCs_Mouse0.74276049
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74194167
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74138142
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73487145
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.72746346
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.72603394
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72419210
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.72389286
111BRD4_25478319_ChIP-Seq_HGPS_Human0.72042554
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.70370442
113NMYC_18555785_Chip-Seq_ESCs_Mouse0.69563448
114SMRT_27268052_Chip-Seq_Bcells_Human0.68705523
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68566974
116SUZ12_18555785_Chip-Seq_ESCs_Mouse0.67864241
117SMAD1_18555785_Chip-Seq_ESCs_Mouse0.67550674
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66380752
119P53_22387025_ChIP-Seq_ESCs_Mouse0.65140864
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.64784884
121RUNX1_27457419_Chip-Seq_LIVER_Mouse0.64508631
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64416085
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.64055806
124KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62699716
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.62313086
126* E2F1_18555785_Chip-Seq_ESCs_Mouse0.61961335
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.61734754
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.60495854
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.60264931
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.59128690
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.58626182
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58599120
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57658920
134* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57225256
135* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57225256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.13975077
2MP0009785_altered_susceptibility_to4.92771546
3MP0002148_abnormal_hypersensitivity_rea4.71792662
4MP0003436_decreased_susceptibility_to4.17339290
5MP0006082_CNS_inflammation4.14535461
6MP0002139_abnormal_hepatobiliary_system3.72905893
7MP0003724_increased_susceptibility_to3.62761438
8* MP0005000_abnormal_immune_tolerance3.57075914
9MP0005025_abnormal_response_to3.42410095
10MP0002419_abnormal_innate_immunity3.35789244
11MP0005671_abnormal_response_to3.09622255
12MP0000685_abnormal_immune_system3.05852369
13MP0001790_abnormal_immune_system2.94059972
14MP0005387_immune_system_phenotype2.94059972
15MP0003303_peritoneal_inflammation2.82322035
16MP0003950_abnormal_plasma_membrane2.72735512
17MP0002452_abnormal_antigen_presenting2.72146255
18MP0009764_decreased_sensitivity_to2.66614372
19MP0002723_abnormal_immune_serum2.64892469
20MP0001727_abnormal_embryo_implantation2.45672705
21MP0004510_myositis2.37178923
22MP0001800_abnormal_humoral_immune2.37079211
23MP0001819_abnormal_immune_cell2.24766509
24MP0002420_abnormal_adaptive_immunity2.16787592
25MP0003329_amyloid_beta_deposits2.15157206
26MP0001533_abnormal_skeleton_physiology2.13091633
27MP0001853_heart_inflammation2.10773508
28MP0004947_skin_inflammation2.05546684
29MP0002006_tumorigenesis1.99362647
30MP0001845_abnormal_inflammatory_respons1.89420551
31MP0003300_gastrointestinal_ulcer1.85050820
32MP0002877_abnormal_melanocyte_morpholog1.83277171
33MP0008469_abnormal_protein_level1.82275226
34MP0003448_altered_tumor_morphology1.79453287
35MP0003075_altered_response_to1.78825078
36MP0005464_abnormal_platelet_physiology1.75983047
37MP0005058_abnormal_lysosome_morphology1.75873039
38MP0002405_respiratory_system_inflammati1.74996886
39MP0005167_abnormal_blood-brain_barrier1.64622783
40MP0005310_abnormal_salivary_gland1.62050511
41MP0010155_abnormal_intestine_physiology1.57075181
42MP0003806_abnormal_nucleotide_metabolis1.53861751
43MP0005647_abnormal_sex_gland1.53777400
44MP0002998_abnormal_bone_remodeling1.53183006
45MP0004782_abnormal_surfactant_physiolog1.48361487
46* MP0000716_abnormal_immune_system1.48352211
47MP0002653_abnormal_ependyma_morphology1.40687838
48MP0003186_abnormal_redox_activity1.38111454
49MP0000858_altered_metastatic_potential1.36589351
50MP0005166_decreased_susceptibility_to1.34397508
51MP0000343_altered_response_to1.32699396
52MP0002398_abnormal_bone_marrow1.29496893
53MP0006054_spinal_hemorrhage1.27477834
54MP0003195_calcinosis1.26284164
55MP0004742_abnormal_vestibular_system1.22385990
56MP0010386_abnormal_urinary_bladder1.22115249
57MP0005164_abnormal_response_to1.20844233
58MP0003690_abnormal_glial_cell1.16706825
59MP0009763_increased_sensitivity_to1.13273420
60MP0002277_abnormal_respiratory_mucosa1.12709851
61MP0005257_abnormal_intraocular_pressure1.11847919
62MP0005410_abnormal_fertilization1.11467143
63MP0005397_hematopoietic_system_phenotyp1.10541261
64MP0001545_abnormal_hematopoietic_system1.10541261
65MP0009278_abnormal_bone_marrow1.10518634
66* MP0002429_abnormal_blood_cell1.09395684
67MP0003656_abnormal_erythrocyte_physiolo1.05690346
68MP0005390_skeleton_phenotype1.05684425
69MP0003191_abnormal_cellular_cholesterol1.05149142
70MP0009333_abnormal_splenocyte_physiolog1.04156513
71MP0008260_abnormal_autophagy1.03466636
72MP0002332_abnormal_exercise_endurance1.03242813
73MP0003136_yellow_coat_color1.03010490
74MP0005365_abnormal_bile_salt1.02394397
75MP0003172_abnormal_lysosome_physiology0.89432214
76MP0005171_absent_coat_pigmentation0.89327180
77MP0000689_abnormal_spleen_morphology0.88640645
78MP0004808_abnormal_hematopoietic_stem0.87600987
79MP0002722_abnormal_immune_system0.84321532
80MP0002163_abnormal_gland_morphology0.83834661
81MP0009840_abnormal_foam_cell0.83341202
82MP0003646_muscle_fatigue0.81631918
83MP0001542_abnormal_bone_strength0.80384218
84MP0002933_joint_inflammation0.78716615
85MP0000569_abnormal_digit_pigmentation0.78286181
86MP0003453_abnormal_keratinocyte_physiol0.77323846
87MP0004484_altered_response_of0.76546803
88MP0003828_pulmonary_edema0.76170906
89MP0002138_abnormal_hepatobiliary_system0.72814179
90MP0001851_eye_inflammation0.71331412
91MP0004883_abnormal_blood_vessel0.70679871
92MP0000604_amyloidosis0.70677318
93MP0008874_decreased_physiological_sensi0.70502184
94MP0000920_abnormal_myelination0.70090994
95MP0001348_abnormal_lacrimal_gland0.69478904
96MP0003091_abnormal_cell_migration0.68806801
97MP0008875_abnormal_xenobiotic_pharmacok0.68102006
98MP0010678_abnormal_skin_adnexa0.67476638
99MP0002166_altered_tumor_susceptibility0.66847624
100MP0010352_gastrointestinal_tract_polyps0.66580549
101MP0000249_abnormal_blood_vessel0.66530049
102MP0005535_abnormal_body_temperature0.65908106
103MP0004043_abnormal_pH_regulation0.65308744
104MP0005319_abnormal_enzyme/_coenzyme0.62397160
105MP0001663_abnormal_digestive_system0.62303063
106MP0000371_diluted_coat_color0.61719737
107MP0005595_abnormal_vascular_smooth0.61053285
108MP0002090_abnormal_vision0.60410560
109MP0009765_abnormal_xenobiotic_induced0.59808538
110MP0005646_abnormal_pituitary_gland0.59628721
111MP0003633_abnormal_nervous_system0.59049806
112MP0002136_abnormal_kidney_physiology0.58307563
113MP0000372_irregular_coat_pigmentation0.58199981
114MP0004019_abnormal_vitamin_homeostasis0.57816199
115MP0002693_abnormal_pancreas_physiology0.56957120
116MP0005076_abnormal_cell_differentiation0.55434510
117MP0001346_abnormal_lacrimal_gland0.54825801
118MP0010307_abnormal_tumor_latency0.54267882
119MP0002254_reproductive_system_inflammat0.54207699
120MP0001501_abnormal_sleep_pattern0.52951018
121MP0003795_abnormal_bone_structure0.51060734
122MP0003045_fibrosis0.50573667
123MP0002295_abnormal_pulmonary_circulatio0.50384611
124MP0005379_endocrine/exocrine_gland_phen0.49609715
125MP0001881_abnormal_mammary_gland0.48679532
126MP0003763_abnormal_thymus_physiology0.47922498
127MP0005451_abnormal_body_composition0.46786392
128MP0008004_abnormal_stomach_pH0.44348394
129MP0005165_increased_susceptibility_to0.42435186

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.53691468
2Recurrent abscess formation (HP:0002722)7.31564713
3Recurrent gram-negative bacterial infections (HP:0005420)6.96797736
4Recurrent bacterial skin infections (HP:0005406)6.94398352
5Mediastinal lymphadenopathy (HP:0100721)5.58550060
6Autoimmune thrombocytopenia (HP:0001973)5.37394984
7Increased IgM level (HP:0003496)5.36534932
8Abnormality of macrophages (HP:0004311)5.29283466
9Elevated erythrocyte sedimentation rate (HP:0003565)5.01538339
10Basal ganglia calcification (HP:0002135)4.57692114
11Stomatitis (HP:0010280)4.53598427
12Loss of speech (HP:0002371)4.48382494
13Vasculitis (HP:0002633)4.43001039
14Dysostosis multiplex (HP:0000943)4.32337909
15Gingivitis (HP:0000230)4.29409279
16Optic neuritis (HP:0100653)4.24113531
17Retrobulbar optic neuritis (HP:0100654)4.24113531
18Recurrent skin infections (HP:0001581)4.23498481
19Orchitis (HP:0100796)4.16193939
20Systemic lupus erythematosus (HP:0002725)4.13870856
21Abnormality of polysaccharide metabolism (HP:0011012)3.90199684
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.90199684
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.90199684
24Recurrent fungal infections (HP:0002841)3.86096120
25Myositis (HP:0100614)3.83906792
26Chronic obstructive pulmonary disease (HP:0006510)3.67013694
27Obstructive lung disease (HP:0006536)3.67013694
28Interstitial pulmonary disease (HP:0006530)3.60028424
29Gastrointestinal infarctions (HP:0005244)3.58315516
30Hypergammaglobulinemia (HP:0010702)3.57845166
31Vacuolated lymphocytes (HP:0001922)3.51467986
32Porencephaly (HP:0002132)3.49925260
33Neurofibrillary tangles (HP:0002185)3.47890504
34Mucopolysacchariduria (HP:0008155)3.44278160
35Urinary glycosaminoglycan excretion (HP:0003541)3.44278160
36Asymmetric septal hypertrophy (HP:0001670)3.44026330
37Recurrent viral infections (HP:0004429)3.30370340
38Periodontitis (HP:0000704)3.17104002
39Mutism (HP:0002300)3.13809299
40Thick nail (HP:0001805)3.08776642
41Poor head control (HP:0002421)3.07481999
42Hyperventilation (HP:0002883)3.04063743
43Apathy (HP:0000741)3.00818653
44Metaphyseal irregularity (HP:0003025)2.99569137
45Axonal loss (HP:0003447)2.98711382
46Diminished motivation (HP:0000745)2.98623769
47Chronic mucocutaneous candidiasis (HP:0002728)2.97040147
48Recurrent cutaneous fungal infections (HP:0011370)2.97040147
49Pulmonary infiltrates (HP:0002113)2.94667010
50Recurrent pneumonia (HP:0006532)2.92725981
51Prostate neoplasm (HP:0100787)2.91991986
52Hematochezia (HP:0002573)2.91792649
53Cellulitis (HP:0100658)2.91298050
54Autoimmune hemolytic anemia (HP:0001890)2.88501496
55Urticaria (HP:0001025)2.81934164
56Purpura (HP:0000979)2.76307570
57Petechiae (HP:0000967)2.74058077
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73069238
59Cleft eyelid (HP:0000625)2.69669366
60Tetraparesis (HP:0002273)2.69583623
61Gingival bleeding (HP:0000225)2.61255753
62Increased serum ferritin (HP:0003281)2.60563100
63J-shaped sella turcica (HP:0002680)2.59981970
64Recurrent lower respiratory tract infections (HP:0002783)2.59581205
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.57649057
66Hemoptysis (HP:0002105)2.55388507
67Increased cerebral lipofuscin (HP:0011813)2.54908449
68Premature loss of primary teeth (HP:0006323)2.52651094
69Joint hemorrhage (HP:0005261)2.52514579
70Prolonged neonatal jaundice (HP:0006579)2.52180291
71Meningitis (HP:0001287)2.51387703
72Pustule (HP:0200039)2.50214680
73Abnormality of the pericardium (HP:0001697)2.49252885
74Chronic otitis media (HP:0000389)2.46398553
75Nuclear cataract (HP:0100018)2.44081675
76Abnormality of liposaccharide metabolism (HP:0010968)2.43490784
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.43490784
78Abnormality of glycolipid metabolism (HP:0010969)2.43490784
79Leukocytosis (HP:0001974)2.41255447
80Joint swelling (HP:0001386)2.40495551
81Abnormality of T cell number (HP:0011839)2.39378391
82Increased CSF protein (HP:0002922)2.36529673
83Inappropriate behavior (HP:0000719)2.36264716
84Arterial thrombosis (HP:0004420)2.35272185
85Progressive neurologic deterioration (HP:0002344)2.31900778
86Osteomyelitis (HP:0002754)2.30150651
87Keratoconjunctivitis sicca (HP:0001097)2.29356039
88Myocardial infarction (HP:0001658)2.29257741
89Skin nodule (HP:0200036)2.26159034
90Gangrene (HP:0100758)2.24842879
91Abnormality of the periventricular white matter (HP:0002518)2.24669513
92Cerebral inclusion bodies (HP:0100314)2.23948761
93Hemorrhage of the eye (HP:0011885)2.22557512
94Hepatosplenomegaly (HP:0001433)2.21208476
95Nephritis (HP:0000123)2.19684715
96Parakeratosis (HP:0001036)2.19607721
97Anorexia (HP:0002039)2.19520961
98Abnormality of iron homeostasis (HP:0011031)2.18669918
99Hypophosphatemic rickets (HP:0004912)2.16615775
100Abnormality of the pleura (HP:0002103)2.13765219
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11766342
102Keratoconjunctivitis (HP:0001096)2.10958061
103Spastic tetraparesis (HP:0001285)2.09601960
104Lower limb hyperreflexia (HP:0002395)2.09324577
105Arthralgia (HP:0002829)2.08644817
106Disinhibition (HP:0000734)2.07200052
107Plagiocephaly (HP:0001357)2.06605262
108Bone pain (HP:0002653)2.05383000
109Nausea (HP:0002018)2.05072063
110Abnormality of the basal ganglia (HP:0002134)2.04004424
111Segmental peripheral demyelination/remyelination (HP:0003481)2.03392347
112Cardiomegaly (HP:0001640)2.03193206
113Progressive visual loss (HP:0000529)2.01208329
114Abnormality of transition element cation homeostasis (HP:0011030)2.00546221
115Glomerulonephritis (HP:0000099)1.98486827
116Peritonitis (HP:0002586)1.97726402
117Irregular vertebral endplates (HP:0003301)1.95656123
118Vertebral compression fractures (HP:0002953)1.94570989
119Neuronal loss in central nervous system (HP:0002529)1.94296522
120Protuberant abdomen (HP:0001538)1.94009420
121Pigmentary retinal degeneration (HP:0001146)1.93865843
122Retinal atrophy (HP:0001105)1.92683722
123Adactyly (HP:0009776)1.92633092
124T lymphocytopenia (HP:0005403)1.91175638
125Micronodular cirrhosis (HP:0001413)1.91149441
126Curly hair (HP:0002212)1.90976225
127IgA deficiency (HP:0002720)1.89940237
128Sepsis (HP:0100806)1.87776614
129Eosinophilia (HP:0001880)1.85259262
130Xanthomatosis (HP:0000991)1.84812224
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.84531981
132Osteolytic defects of the hand bones (HP:0009699)1.84531981
133Skin ulcer (HP:0200042)1.83850952
134Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83366756
135Gastrointestinal stroma tumor (HP:0100723)1.82548626
136Agnosia (HP:0010524)1.82201996
137Global brain atrophy (HP:0002283)1.80753828
138Cerebral hemorrhage (HP:0001342)1.77932901
139Abnormality of the vertebral endplates (HP:0005106)1.77418014
140Fused cervical vertebrae (HP:0002949)1.76140230
141Recurrent bronchitis (HP:0002837)1.75937128
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.74912245
143Peripheral demyelination (HP:0011096)1.74803164
144Abnormality of the costochondral junction (HP:0000919)1.74720674
145Concave nail (HP:0001598)1.74400088
146Hypophosphatemia (HP:0002148)1.74388098
147Upper limb muscle weakness (HP:0003484)1.72481083
148Pathologic fracture (HP:0002756)1.72074184
149Ovoid vertebral bodies (HP:0003300)1.71874233
150Spondylolisthesis (HP:0003302)1.71504248
151Dementia (HP:0000726)1.70955683
152Tubulointerstitial fibrosis (HP:0005576)1.70693329
153Generalized aminoaciduria (HP:0002909)1.70541195
154Supranuclear gaze palsy (HP:0000605)1.69725018
155Deformed sella turcica (HP:0002681)1.68041967
156Enlarged epiphyses (HP:0010580)1.67451704
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65160552
158Rickets (HP:0002748)1.65060614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.74047275
2MAP3K145.41090108
3RIPK44.51396495
4BLK3.86265397
5IRAK43.39599445
6TBK13.37363525
7TYK22.73254658
8JAK32.64859623
9IKBKE2.63922087
10IKBKB2.61396995
11IRAK32.58494714
12TAOK22.36753636
13MAP3K132.30252141
14MST1R2.16542701
15TXK2.15709417
16STK242.15505894
17DDR22.14171572
18PIM22.13356905
19BMPR22.12774685
20JAK11.82913347
21MST41.72727495
22CHUK1.63150889
23BMX1.61559254
24MAP3K111.54989200
25TGFBR21.51130537
26TAOK11.50455638
27ARAF1.41615741
28NEK91.40340468
29MAP3K31.40283072
30ABL21.39044188
31TIE11.38403135
32IRAK21.33823497
33NME21.30381317
34IRAK11.28518858
35ERN11.28186147
36SYK1.28095447
37ERBB31.26235486
38EIF2AK21.25998002
39GRK11.25021250
40CSK1.24783578
41LIMK11.17664022
42MAP4K11.14566259
43STK38L1.11681166
44STK41.08233778
45MARK31.06955833
46CDC42BPA1.05529251
47KIT1.05346629
48MAP3K91.00349160
49TESK20.99872859
50EIF2AK30.98851642
51SIK30.98845657
52HCK0.97401668
53LYN0.97123376
54ZAP700.96207175
55PIM10.95748562
56TRPM70.95408010
57YES10.92224078
58MAP2K60.90625810
59MAP3K120.87855488
60JAK20.86032778
61MAP2K30.85233620
62LCK0.83750143
63MAP3K50.83488291
64MATK0.82312258
65FGR0.80851793
66ERBB40.78085153
67BMPR1B0.76201952
68PRKCD0.73179641
69CAMKK20.71368508
70BTK0.70843439
71PRKCQ0.69973880
72BCR0.69810249
73FLT30.67565082
74RPS6KA40.64795434
75CAMK1D0.62379756
76EPHB10.60963772
77PAK40.57508819
78ABL10.57105750
79PDGFRB0.56036073
80EPHA30.55782401
81EPHA20.53887529
82FGFR30.53613386
83MAPK150.53283462
84RPS6KA20.52845261
85GRK70.51537151
86ADRBK20.51048805
87RPS6KC10.50375855
88RPS6KL10.50375855
89TESK10.50222485
90MAPK40.49540239
91GRK50.49518020
92PLK20.49437612
93DAPK30.49176532
94FRK0.48747941
95PRKG20.48175591
96PDK20.47785083
97FGFR40.47504550
98EGFR0.46305158
99GRK60.43558433
100MAP3K100.43465973
101GSK3A0.42911716
102TEC0.41280922
103MUSK0.41206716
104MOS0.37742284
105PIK3CG0.36971125
106PDGFRA0.36517428
107MET0.36105466
108PRKCE0.36091767
109PKN10.35494266
110PTK2B0.34797212
111MAPKAPK50.34033643
112CAMK40.33655138
113CLK10.32751808
114CSF1R0.31165592
115TAOK30.30801153
116FER0.29187680
117STK30.29133864
118DAPK20.28817523
119FES0.28338855
120CAMK1G0.25455341
121ADRBK10.25398085
122MELK0.25342309
123PRPF4B0.24895273
124BRAF0.21608943
125IGF1R0.21351715
126RIPK10.21292168
127NLK0.20726877
128INSR0.19982082
129MAP3K10.19121443
130FYN0.18686992
131RPS6KA10.18653727
132TTN0.18134845
133MAPKAPK20.16718224
134SIK20.15931499
135RPS6KA50.15714476
136KSR20.15345690
137EPHB20.14351671
138PDPK10.13313558
139PDK10.11587365
140STK100.11045402
141RPS6KA60.10844231
142ACVR1B0.10474123
143SRC0.09849538
144LRRK20.08803084

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.75731705
2Allograft rejection_Homo sapiens_hsa053303.95193389
3Type I diabetes mellitus_Homo sapiens_hsa049403.39458827
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.22607798
5Leishmaniasis_Homo sapiens_hsa051403.20164321
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.96984473
7Rheumatoid arthritis_Homo sapiens_hsa053232.79588500
8Legionellosis_Homo sapiens_hsa051342.76349595
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.72326857
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.54995688
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.49827594
12Malaria_Homo sapiens_hsa051442.38757957
13Asthma_Homo sapiens_hsa053102.35970827
14Pertussis_Homo sapiens_hsa051332.35896008
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.25544120
16African trypanosomiasis_Homo sapiens_hsa051432.18969003
17Staphylococcus aureus infection_Homo sapiens_hsa051502.14850229
18Measles_Homo sapiens_hsa051622.14506096
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12555173
20Tuberculosis_Homo sapiens_hsa051522.09531443
21Autoimmune thyroid disease_Homo sapiens_hsa053201.99235681
22Influenza A_Homo sapiens_hsa051641.98153226
23TNF signaling pathway_Homo sapiens_hsa046681.96631397
24Osteoclast differentiation_Homo sapiens_hsa043801.85643704
25Salmonella infection_Homo sapiens_hsa051321.82908127
26Bladder cancer_Homo sapiens_hsa052191.67712321
27* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63367138
28Herpes simplex infection_Homo sapiens_hsa051681.53163743
29Phagosome_Homo sapiens_hsa041451.47299171
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39863668
31Hematopoietic cell lineage_Homo sapiens_hsa046401.34896996
32Toxoplasmosis_Homo sapiens_hsa051451.34696228
33Chemokine signaling pathway_Homo sapiens_hsa040621.29386652
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24543600
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.17014538
36Viral myocarditis_Homo sapiens_hsa054161.15694427
37Prion diseases_Homo sapiens_hsa050201.14488384
38Lysosome_Homo sapiens_hsa041421.07707290
39Sulfur metabolism_Homo sapiens_hsa009201.04375551
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01933788
41Apoptosis_Homo sapiens_hsa042100.98590361
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97216092
43Shigellosis_Homo sapiens_hsa051310.96214253
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95966766
45PPAR signaling pathway_Homo sapiens_hsa033200.93408963
46Collecting duct acid secretion_Homo sapiens_hsa049660.91756881
47Amoebiasis_Homo sapiens_hsa051460.89673145
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88825822
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.86285809
50Hepatitis B_Homo sapiens_hsa051610.85682236
51Hepatitis C_Homo sapiens_hsa051600.85663055
52Antigen processing and presentation_Homo sapiens_hsa046120.85539894
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85346465
54B cell receptor signaling pathway_Homo sapiens_hsa046620.84667873
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79082539
56Primary immunodeficiency_Homo sapiens_hsa053400.78549511
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75150257
58Notch signaling pathway_Homo sapiens_hsa043300.71643024
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66437602
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61612851
61Fructose and mannose metabolism_Homo sapiens_hsa000510.54889637
62Tryptophan metabolism_Homo sapiens_hsa003800.54240090
63Complement and coagulation cascades_Homo sapiens_hsa046100.53880810
64Galactose metabolism_Homo sapiens_hsa000520.50513926
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.50000910
66Prolactin signaling pathway_Homo sapiens_hsa049170.49984135
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49096047
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49002994
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.48290145
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47830629
71VEGF signaling pathway_Homo sapiens_hsa043700.46836882
72T cell receptor signaling pathway_Homo sapiens_hsa046600.46674191
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43773106
74Other glycan degradation_Homo sapiens_hsa005110.41376032
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41164004
76Type II diabetes mellitus_Homo sapiens_hsa049300.40273438
77Vibrio cholerae infection_Homo sapiens_hsa051100.33903778
78Platelet activation_Homo sapiens_hsa046110.32653081
79Acute myeloid leukemia_Homo sapiens_hsa052210.32483647
80Selenocompound metabolism_Homo sapiens_hsa004500.32470649
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32182323
82Proteasome_Homo sapiens_hsa030500.32054067
83Renal cell carcinoma_Homo sapiens_hsa052110.31418299
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30687517
85Ether lipid metabolism_Homo sapiens_hsa005650.29997574
86Mineral absorption_Homo sapiens_hsa049780.29024499
87Epstein-Barr virus infection_Homo sapiens_hsa051690.28289579
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27523360
89Fatty acid biosynthesis_Homo sapiens_hsa000610.27161015
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26767291
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25499342
92Steroid biosynthesis_Homo sapiens_hsa001000.24319077
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.23957565
94Dorso-ventral axis formation_Homo sapiens_hsa043200.23839145
95Systemic lupus erythematosus_Homo sapiens_hsa053220.21236035
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20701320
97HIF-1 signaling pathway_Homo sapiens_hsa040660.20610760
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.19160229
99GnRH signaling pathway_Homo sapiens_hsa049120.17563687
100Renin-angiotensin system_Homo sapiens_hsa046140.16610754
101Endocytosis_Homo sapiens_hsa041440.16292185
102Glycerolipid metabolism_Homo sapiens_hsa005610.15660976
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.14634782
104Rap1 signaling pathway_Homo sapiens_hsa040150.14385091
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13436042
106Viral carcinogenesis_Homo sapiens_hsa052030.11886315
107Chronic myeloid leukemia_Homo sapiens_hsa052200.11122226
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09402500
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09322785
110Proteoglycans in cancer_Homo sapiens_hsa052050.08199848
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07939519
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07208849
113Synaptic vesicle cycle_Homo sapiens_hsa047210.06558973
114Pancreatic cancer_Homo sapiens_hsa052120.05748382
115HTLV-I infection_Homo sapiens_hsa051660.05004667
116FoxO signaling pathway_Homo sapiens_hsa040680.04051415
117Insulin resistance_Homo sapiens_hsa049310.03108058
118MAPK signaling pathway_Homo sapiens_hsa040100.02754819
119Small cell lung cancer_Homo sapiens_hsa052220.01259818
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01131007
121Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0458453
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0415360
123Sphingolipid metabolism_Homo sapiens_hsa00600-0.0054434

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