TNFSF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.40601989
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12016502
3regulation of activation of Janus kinase activity (GO:0010533)5.97564997
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.70617090
5positive regulation of natural killer cell differentiation (GO:0032825)5.52405864
6T-helper 1 type immune response (GO:0042088)5.35380078
7* regulation of T-helper 1 cell differentiation (GO:0045625)5.27975470
8protein neddylation (GO:0045116)5.21606390
9regulation of platelet aggregation (GO:0090330)5.15939722
10antigen processing and presentation of endogenous antigen (GO:0019883)4.96440588
11negative regulation of thymocyte apoptotic process (GO:0070244)4.93032825
12neutrophil activation involved in immune response (GO:0002283)4.82076673
13* positive regulation of T-helper cell differentiation (GO:0045624)4.80455747
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.72243020
15angiogenesis involved in wound healing (GO:0060055)4.67717772
16regulation of platelet activation (GO:0010543)4.64247524
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60978478
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60682243
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60682243
20positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.46115035
21regulation of dendritic cell antigen processing and presentation (GO:0002604)4.42168032
22myeloid dendritic cell differentiation (GO:0043011)4.36449871
23positive regulation of antigen processing and presentation (GO:0002579)4.34634200
24platelet aggregation (GO:0070527)4.29519680
25* positive regulation of alpha-beta T cell proliferation (GO:0046641)4.28560484
26positive regulation of mast cell activation (GO:0033005)4.26184670
27* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.25298320
28type I interferon signaling pathway (GO:0060337)4.24204149
29cellular response to type I interferon (GO:0071357)4.24204149
30positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.22323395
31granulocyte activation (GO:0036230)4.19106758
32eosinophil chemotaxis (GO:0048245)4.18365048
33purinergic nucleotide receptor signaling pathway (GO:0035590)4.18121351
34response to type I interferon (GO:0034340)4.17206817
35natural killer cell mediated immunity (GO:0002228)4.15319336
36natural killer cell mediated cytotoxicity (GO:0042267)4.15319336
37* positive regulation of type 2 immune response (GO:0002830)4.11684410
38myeloid dendritic cell activation (GO:0001773)4.10023505
39NIK/NF-kappaB signaling (GO:0038061)4.05913842
40* regulation of T-helper cell differentiation (GO:0045622)4.05445128
41negative regulation of cell killing (GO:0031342)4.04862385
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04862385
43monocyte chemotaxis (GO:0002548)4.04530863
44neutrophil activation (GO:0042119)4.01700569
45regulation of hypersensitivity (GO:0002883)4.01120369
46* positive regulation of interleukin-12 production (GO:0032735)4.00767788
47regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.00752069
48positive regulation of humoral immune response (GO:0002922)4.00263159
49regulation of T cell tolerance induction (GO:0002664)3.99784136
50* regulation of alpha-beta T cell proliferation (GO:0046640)3.98779148
51negative regulation of viral genome replication (GO:0045071)3.94946871
52positive regulation of B cell differentiation (GO:0045579)3.94692800
53megakaryocyte development (GO:0035855)3.94447960
54cellular response to zinc ion (GO:0071294)3.94116872
55positive regulation of monocyte chemotaxis (GO:0090026)3.93403182
56response to peptidoglycan (GO:0032494)3.93200034
57histamine secretion (GO:0001821)3.91106924
58positive regulation of interleukin-17 production (GO:0032740)3.90589135
59positive regulation of interferon-alpha production (GO:0032727)3.90162034
60negative regulation of T cell apoptotic process (GO:0070233)3.88929291
61blood coagulation, intrinsic pathway (GO:0007597)3.87363336
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.87300945
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.86737734
64dendritic cell chemotaxis (GO:0002407)3.86370320
65regulation of RIG-I signaling pathway (GO:0039535)3.84115112
66positive regulation of endothelial cell differentiation (GO:0045603)3.82973175
67regulation of B cell receptor signaling pathway (GO:0050855)3.81360636
68regulation of mononuclear cell migration (GO:0071675)3.79123747
69* positive regulation of interleukin-2 production (GO:0032743)3.74926865
70autophagic vacuole fusion (GO:0000046)3.73766562
71positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.71504882
72positive regulation of gamma-delta T cell activation (GO:0046645)3.70933779
73regulation of chronic inflammatory response (GO:0002676)3.69541940
74eosinophil migration (GO:0072677)3.69020750
75regulation of interferon-alpha production (GO:0032647)3.65379673
76cellular response to interferon-beta (GO:0035458)3.64868942
77natural killer cell differentiation (GO:0001779)3.64441062
78regulation of antigen processing and presentation (GO:0002577)3.64425276
79* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.61414876
80negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.60055012
81response to interferon-beta (GO:0035456)3.59617863
82regulation of natural killer cell differentiation (GO:0032823)3.57935644
83regulation of interleukin-12 biosynthetic process (GO:0045075)3.57168534
84response to muramyl dipeptide (GO:0032495)3.57082422
85* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.55913121
86* regulation of T-helper 2 cell differentiation (GO:0045628)3.54408359
87* positive regulation of activated T cell proliferation (GO:0042104)3.53478045
88modulation by symbiont of host immune response (GO:0052553)3.53042948
89positive regulation by symbiont of host defense response (GO:0052509)3.53042948
90modulation by symbiont of host defense response (GO:0052031)3.53042948
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53042948
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53042948
93positive regulation by organism of defense response of other organism involved in symbiotic interact3.53042948
94negative thymic T cell selection (GO:0045060)3.51522832
95leukocyte degranulation (GO:0043299)3.51297341
96regulation of homotypic cell-cell adhesion (GO:0034110)3.50289095
97positive regulation of granulocyte differentiation (GO:0030854)3.49289992
98adenosine metabolic process (GO:0046085)3.47871063
99leukocyte migration involved in inflammatory response (GO:0002523)3.46698624
100response to interferon-alpha (GO:0035455)3.46289480
101regulation of integrin-mediated signaling pathway (GO:2001044)3.44507699
102defense response to protozoan (GO:0042832)3.44100703
103natural killer cell activation (GO:0030101)3.39492586
104dendritic cell differentiation (GO:0097028)3.37809623
105regulation of integrin activation (GO:0033623)3.32075950
106negative T cell selection (GO:0043383)3.30529638
107positive regulation of heat generation (GO:0031652)3.30503618
108endothelium development (GO:0003158)3.29883877
109interferon-gamma-mediated signaling pathway (GO:0060333)3.29581139
110triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.29528283
111positive regulation of cytokine biosynthetic process (GO:0042108)3.29092118
112adenosine receptor signaling pathway (GO:0001973)3.28649897
113B cell receptor signaling pathway (GO:0050853)3.28162549
114dendritic cell migration (GO:0036336)3.26720690
115regulation of mast cell activation (GO:0033003)3.25360704
116negative regulation of platelet activation (GO:0010544)3.25329491
117regulation of germinal center formation (GO:0002634)3.23777973
118positive regulation of hemostasis (GO:1900048)3.22407517
119positive regulation of blood coagulation (GO:0030194)3.22407517
120* regulation of immunoglobulin secretion (GO:0051023)3.22129048
121positive regulation of natural killer cell mediated immunity (GO:0002717)3.21316434
122regulation of fever generation (GO:0031620)3.21065003
123regulation of Golgi to plasma membrane protein transport (GO:0042996)3.20811379
124purinergic receptor signaling pathway (GO:0035587)3.20804248
125mast cell activation (GO:0045576)3.20803001
126regulation of interferon-gamma biosynthetic process (GO:0045072)3.20342347
127* regulation of interleukin-17 production (GO:0032660)3.20224191
128positive regulation of T-helper 1 type immune response (GO:0002827)3.19969892
129platelet degranulation (GO:0002576)3.17848854
130immunoglobulin mediated immune response (GO:0016064)3.16179779
131* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.15386461
132negative regulation of norepinephrine secretion (GO:0010700)3.15149887
133positive regulation of natural killer cell activation (GO:0032816)3.15074898
134platelet activation (GO:0030168)3.12651030
135regulation of lipoprotein metabolic process (GO:0050746)3.12222119
136regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.11728087
137positive regulation of Rho protein signal transduction (GO:0035025)3.11722064
138positive regulation of macrophage differentiation (GO:0045651)3.11663615
139organelle membrane fusion (GO:0090174)3.11188250
140natural killer cell activation involved in immune response (GO:0002323)3.10956068
141regulation of tolerance induction (GO:0002643)3.10807797
142* regulation of interleukin-12 production (GO:0032655)3.09033043
143* positive regulation of T cell proliferation (GO:0042102)3.07626766
144regulation of B cell differentiation (GO:0045577)3.06197666
145G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.05971739
146regulation of chemokine-mediated signaling pathway (GO:0070099)3.04789191
147positive regulation of T cell differentiation in thymus (GO:0033089)3.04527659
148regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01686701
149regulation of natural killer cell mediated immunity (GO:0002715)3.01686701
150negative regulation of homotypic cell-cell adhesion (GO:0034111)3.00526202
151response to protozoan (GO:0001562)3.00054158
152positive regulation of response to biotic stimulus (GO:0002833)2.99633434
153positive regulation of interferon-beta production (GO:0032728)2.96744505
154histamine transport (GO:0051608)2.95822645
155regulation of natural killer cell activation (GO:0032814)2.95723414
156* regulation of T-helper 1 type immune response (GO:0002825)2.95232380
157positive regulation of chemokine biosynthetic process (GO:0045080)2.94760104
158pyrimidine nucleoside catabolic process (GO:0046135)2.94234461
159positive regulation of coagulation (GO:0050820)2.90820913
160positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.90130908
161homotypic cell-cell adhesion (GO:0034109)2.89885990
162cytidine deamination (GO:0009972)2.88921370
163cytidine metabolic process (GO:0046087)2.88921370
164cytidine catabolic process (GO:0006216)2.88921370
165mast cell degranulation (GO:0043303)2.87526564
166mast cell activation involved in immune response (GO:0002279)2.87526564
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.86775413
168myeloid cell activation involved in immune response (GO:0002275)2.84997261
169regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81401083
170low-density lipoprotein particle remodeling (GO:0034374)2.81172286
171regulation of mast cell degranulation (GO:0043304)2.80148384
172regulation of thymocyte apoptotic process (GO:0070243)2.79754808
173positive regulation of mast cell degranulation (GO:0043306)2.79361916
174positive regulation of mast cell activation involved in immune response (GO:0033008)2.79361916
175tolerance induction (GO:0002507)2.78461551
176B cell mediated immunity (GO:0019724)2.77221511
177negative regulation of calcium ion transport into cytosol (GO:0010523)2.77115659
178Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76140542
179platelet formation (GO:0030220)2.75555124
180regulation of endothelial cell differentiation (GO:0045601)2.74295499
181regulation of mast cell activation involved in immune response (GO:0033006)2.70582995
182positive regulation of immune response to tumor cell (GO:0002839)2.69918208
183regulation of immune response to tumor cell (GO:0002837)2.69918208
184regulation of response to tumor cell (GO:0002834)2.69918208
185positive regulation of response to tumor cell (GO:0002836)2.69918208
186definitive hemopoiesis (GO:0060216)2.62820007
187positive regulation of cAMP-mediated signaling (GO:0043950)2.61674459
188phagocytosis, engulfment (GO:0006911)2.61674249
189tyrosine phosphorylation of STAT protein (GO:0007260)2.61151216
190negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.60814564
191regulation of blood coagulation (GO:0030193)2.57706888
192regulation of hemostasis (GO:1900046)2.57706888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.24516119
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.44953081
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.72002781
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.57045288
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.27878982
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.85651796
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.81963669
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.66284970
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57175958
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39342482
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.34095895
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20073405
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.19434118
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.14091547
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11638158
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00784079
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78406869
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75655605
19GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.48531241
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.17754416
21GATA1_19941826_ChIP-Seq_K562_Human2.05839526
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97655367
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94802110
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94417339
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93705874
26GATA2_19941826_ChIP-Seq_K562_Human1.90892714
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.85229557
28SPI1_23547873_ChIP-Seq_NB4_Human1.83172707
29* MYB_26560356_Chip-Seq_TH2_Human1.81490545
30RUNX_20019798_ChIP-Seq_JUKART_Human1.80808985
31VDR_24787735_ChIP-Seq_THP-1_Human1.79352574
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.72159481
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71846326
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67331764
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.59621602
36MAF_26560356_Chip-Seq_TH1_Human1.58492015
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57425980
38* MYB_26560356_Chip-Seq_TH1_Human1.54357344
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53796932
40SCL_19346495_ChIP-Seq_HPC-7_Human1.51887858
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47561339
42VDR_24763502_ChIP-Seq_THP-1_Human1.46756274
43* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45683647
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44841333
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44386676
46* PU_27001747_Chip-Seq_BMDM_Mouse1.42804230
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37106109
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37010296
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34962937
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32388873
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.31259048
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31057076
53GATA3_27048872_Chip-Seq_THYMUS_Human1.28979588
54* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28274644
55GATA3_26560356_Chip-Seq_TH2_Human1.28079789
56* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27574728
57GBX2_23144817_ChIP-Seq_PC3_Human1.26114084
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23562366
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18324802
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17857200
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17390942
62GATA1_22025678_ChIP-Seq_K562_Human1.16296241
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15200751
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14368318
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13882780
66* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11723314
67SPI1_23127762_ChIP-Seq_K562_Human1.10491316
68* SALL4_22934838_ChIP-ChIP_CD34+_Human1.08454086
69GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03545410
70* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03295880
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03222912
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02231895
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00643785
74EGR1_19032775_ChIP-ChIP_M12_Human0.99576678
75TP53_16413492_ChIP-PET_HCT116_Human0.99389371
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97331937
77VDR_21846776_ChIP-Seq_THP-1_Human0.96989652
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.96700768
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96592635
80* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96430106
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95896409
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95386202
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94504326
84VDR_22108803_ChIP-Seq_LS180_Human0.92753934
85* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92645378
86* CRX_20693478_ChIP-Seq_RETINA_Mouse0.90894343
87* NFE2_27457419_Chip-Seq_LIVER_Mouse0.90259326
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89453134
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88373597
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87750829
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86636335
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86607260
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86034373
94* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85933389
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85646338
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84433395
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84180652
98IRF1_19129219_ChIP-ChIP_H3396_Human0.84178221
99CDX2_22108803_ChIP-Seq_LS180_Human0.84099444
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.83284472
101TCF4_18268006_ChIP-ChIP_LS174T_Human0.83130974
102HTT_18923047_ChIP-ChIP_STHdh_Human0.83045928
103* P53_22387025_ChIP-Seq_ESCs_Mouse0.82984597
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82491878
105MAF_26560356_Chip-Seq_TH2_Human0.81765423
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80958467
107* UTX_26944678_Chip-Seq_JUKART_Human0.80899684
108TAF15_26573619_Chip-Seq_HEK293_Human0.80879439
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79081457
110* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79058340
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77733829
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77733829
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76818849
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76249754
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75970624
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.75562522
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.73137767
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.72694193
119* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72367407
120* SMRT_27268052_Chip-Seq_Bcells_Human0.72014180
121TCF7_22412390_ChIP-Seq_EML_Mouse0.70246136
122KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70143921
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68694743
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.68471340
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.68471340
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66633378
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.65974816
128SOX2_20726797_ChIP-Seq_SW620_Human0.65201764
129* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60885898
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.58170311
131* ELK3_25401928_ChIP-Seq_HUVEC_Human0.56822600
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56607741
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55864747
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54970323
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.54646947
136ELK1_19687146_ChIP-ChIP_HELA_Human0.54032126
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.53764579
138ELF1_17652178_ChIP-ChIP_JURKAT_Human0.51371637
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.51305450
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.51166355
141ZNF263_19887448_ChIP-Seq_K562_Human0.51111933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation5.23015943
2MP0009785_altered_susceptibility_to4.52717026
3MP0000685_abnormal_immune_system4.30814805
4* MP0002148_abnormal_hypersensitivity_rea4.24859487
5MP0003436_decreased_susceptibility_to4.00418241
6MP0005671_abnormal_response_to4.00376170
7* MP0005000_abnormal_immune_tolerance3.48640714
8MP0008004_abnormal_stomach_pH3.42446748
9MP0001790_abnormal_immune_system3.39552424
10MP0005387_immune_system_phenotype3.39552424
11MP0000465_gastrointestinal_hemorrhage3.38815041
12MP0003724_increased_susceptibility_to3.17221427
13MP0005025_abnormal_response_to3.16817108
14MP0001348_abnormal_lacrimal_gland3.10874976
15MP0006082_CNS_inflammation2.81988171
16MP0002419_abnormal_innate_immunity2.79362510
17* MP0002723_abnormal_immune_serum2.72071967
18MP0001800_abnormal_humoral_immune2.71851717
19* MP0002452_abnormal_antigen_presenting2.68178920
20MP0002163_abnormal_gland_morphology2.50876238
21* MP0001819_abnormal_immune_cell2.42230232
22MP0004510_myositis2.38325113
23* MP0002420_abnormal_adaptive_immunity2.36049172
24MP0002006_tumorigenesis2.35270867
25MP0002166_altered_tumor_susceptibility2.26050401
26MP0009764_decreased_sensitivity_to2.17586569
27MP0006054_spinal_hemorrhage2.14949860
28MP0004084_abnormal_cardiac_muscle2.13102838
29MP0005084_abnormal_gallbladder_morpholo2.10240378
30MP0005310_abnormal_salivary_gland2.07275900
31MP0001853_heart_inflammation1.96562970
32MP0001533_abnormal_skeleton_physiology1.95989139
33MP0001346_abnormal_lacrimal_gland1.93592866
34MP0002405_respiratory_system_inflammati1.88573207
35MP0003303_peritoneal_inflammation1.87020429
36MP0002138_abnormal_hepatobiliary_system1.85172737
37* MP0000716_abnormal_immune_system1.84497527
38MP0004947_skin_inflammation1.84270610
39MP0001845_abnormal_inflammatory_respons1.84009147
40* MP0002398_abnormal_bone_marrow1.78639744
41MP0005464_abnormal_platelet_physiology1.77429358
42MP0000230_abnormal_systemic_arterial1.73449606
43MP0008469_abnormal_protein_level1.68398557
44MP0010155_abnormal_intestine_physiology1.63843709
45MP0005058_abnormal_lysosome_morphology1.53550097
46MP0008775_abnormal_heart_ventricle1.51390899
47* MP0002429_abnormal_blood_cell1.43811913
48MP0005379_endocrine/exocrine_gland_phen1.39924243
49MP0002132_abnormal_respiratory_system1.38674598
50MP0008872_abnormal_physiological_respon1.38481451
51MP0003448_altered_tumor_morphology1.38009553
52MP0010368_abnormal_lymphatic_system1.34490696
53MP0003763_abnormal_thymus_physiology1.34304090
54MP0000689_abnormal_spleen_morphology1.28593131
55MP0009333_abnormal_splenocyte_physiolog1.27174421
56MP0003075_altered_response_to1.26722483
57MP0002722_abnormal_immune_system1.26621396
58MP0001879_abnormal_lymphatic_vessel1.23525916
59MP0005397_hematopoietic_system_phenotyp1.22684569
60MP0001545_abnormal_hematopoietic_system1.22684569
61MP0009697_abnormal_copulation1.21676317
62MP0005646_abnormal_pituitary_gland1.20582770
63MP0002009_preneoplasia1.19651880
64MP0004036_abnormal_muscle_relaxation1.18148291
65MP0003045_fibrosis1.12949709
66MP0005083_abnormal_biliary_tract1.07188748
67MP0005410_abnormal_fertilization1.06207143
68MP0005623_abnormal_meninges_morphology1.06030036
69MP0000343_altered_response_to1.05502629
70MP0003638_abnormal_response/metabolism_1.04756287
71MP0000858_altered_metastatic_potential1.03448487
72MP0002998_abnormal_bone_remodeling1.03293029
73MP0002877_abnormal_melanocyte_morpholog1.02947955
74MP0002277_abnormal_respiratory_mucosa1.01169197
75MP0002736_abnormal_nociception_after1.00958781
76MP0002254_reproductive_system_inflammat0.97324152
77MP0000015_abnormal_ear_pigmentation0.96932696
78MP0009763_increased_sensitivity_to0.95150330
79MP0004130_abnormal_muscle_cell0.92903591
80MP0005165_increased_susceptibility_to0.90854830
81MP0001663_abnormal_digestive_system0.90548181
82MP0002933_joint_inflammation0.87179995
83MP0005390_skeleton_phenotype0.86843762
84MP0003091_abnormal_cell_migration0.86614008
85MP0001881_abnormal_mammary_gland0.85197227
86MP0003191_abnormal_cellular_cholesterol0.83998425
87MP0004808_abnormal_hematopoietic_stem0.83915421
88MP0004484_altered_response_of0.82858290
89MP0004782_abnormal_surfactant_physiolog0.82295289
90MP0009840_abnormal_foam_cell0.82251531
91MP0003453_abnormal_keratinocyte_physiol0.81878040
92MP0003183_abnormal_peptide_metabolism0.81752049
93MP0003950_abnormal_plasma_membrane0.80842926
94MP0010307_abnormal_tumor_latency0.80609368
95MP0005166_decreased_susceptibility_to0.80220652
96MP0003828_pulmonary_edema0.78664158
97MP0003656_abnormal_erythrocyte_physiolo0.78590193
98MP0001765_abnormal_ion_homeostasis0.78309761
99MP0001968_abnormal_touch/_nociception0.77725673
100MP0004883_abnormal_blood_vessel0.77288312
101MP0000604_amyloidosis0.75693613
102MP0000703_abnormal_thymus_morphology0.75119787
103MP0009278_abnormal_bone_marrow0.74951457
104MP0003186_abnormal_redox_activity0.74523978
105MP0008874_decreased_physiological_sensi0.73595205
106MP0003795_abnormal_bone_structure0.72690339
107* MP0009642_abnormal_blood_homeostasis0.71245841
108MP0002128_abnormal_blood_circulation0.70735074
109MP0003172_abnormal_lysosome_physiology0.70359264
110MP0003866_abnormal_defecation0.69229719
111MP0002102_abnormal_ear_morphology0.67734860
112MP0004215_abnormal_myocardial_fiber0.67489002
113MP0005164_abnormal_response_to0.64913203
114MP0003279_aneurysm0.63056519
115MP0005174_abnormal_tail_pigmentation0.61900340
116MP0001851_eye_inflammation0.61900237
117MP0002693_abnormal_pancreas_physiology0.61485878
118MP0003690_abnormal_glial_cell0.60652324
119MP0005023_abnormal_wound_healing0.59959407
120MP0000627_abnormal_mammary_gland0.59553461
121MP0009765_abnormal_xenobiotic_induced0.58716667
122MP0004134_abnormal_chest_morphology0.58052188
123MP0003566_abnormal_cell_adhesion0.57528966
124* MP0000249_abnormal_blood_vessel0.57349869
125MP0009780_abnormal_chondrocyte_physiolo0.56340286
126MP0001873_stomach_inflammation0.55391100
127MP0002396_abnormal_hematopoietic_system0.55087048
128MP0000490_abnormal_crypts_of0.55049141
129MP0005076_abnormal_cell_differentiation0.54479167
130MP0003943_abnormal_hepatobiliary_system0.52337188
131MP0000569_abnormal_digit_pigmentation0.49532759
132MP0002136_abnormal_kidney_physiology0.45773699
133MP0005167_abnormal_blood-brain_barrier0.45459812
134MP0002876_abnormal_thyroid_physiology0.44385036
135MP0003300_gastrointestinal_ulcer0.44378090
136MP0001915_intracranial_hemorrhage0.43396459
137MP0000371_diluted_coat_color0.42636615
138MP0002019_abnormal_tumor_incidence0.42231502
139MP0003252_abnormal_bile_duct0.41937094
140MP0000920_abnormal_myelination0.40191582

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.25547461
2Menorrhagia (HP:0000132)8.27364199
3Increased mean platelet volume (HP:0011877)8.11927612
4Abnormal platelet volume (HP:0011876)7.78178960
5Elevated erythrocyte sedimentation rate (HP:0003565)5.78636233
6Orchitis (HP:0100796)5.76041950
7Retrobulbar optic neuritis (HP:0100654)5.74621239
8Optic neuritis (HP:0100653)5.74621239
9Eczematoid dermatitis (HP:0000976)5.68697906
10Increased IgM level (HP:0003496)5.65804805
11Recurrent abscess formation (HP:0002722)5.64870519
12Myositis (HP:0100614)5.60959114
13Recurrent bacterial skin infections (HP:0005406)5.56637732
14Autoimmune thrombocytopenia (HP:0001973)5.26689872
15Abnormal platelet function (HP:0011869)4.88504148
16Impaired platelet aggregation (HP:0003540)4.88504148
17Recurrent gram-negative bacterial infections (HP:0005420)4.80622817
18Spontaneous hematomas (HP:0007420)4.69394593
19Vasculitis (HP:0002633)4.37109815
20Mediastinal lymphadenopathy (HP:0100721)4.36522844
21Recurrent fungal infections (HP:0002841)4.23051657
22Chronic otitis media (HP:0000389)4.17433965
23Abnormality of macrophages (HP:0004311)4.14607701
24Recurrent viral infections (HP:0004429)4.00785967
25Hyperlipoproteinemia (HP:0010980)3.96054914
26Gastrointestinal infarctions (HP:0005244)3.88219000
27Basal ganglia calcification (HP:0002135)3.78659645
28Recurrent skin infections (HP:0001581)3.77985252
29Stomatitis (HP:0010280)3.69113451
30Hypergammaglobulinemia (HP:0010702)3.63594118
31Arterial thrombosis (HP:0004420)3.48545234
32Dyschromatopsia (HP:0007641)3.47216226
33Bruising susceptibility (HP:0000978)3.40980128
34Abnormality of T cell number (HP:0011839)3.37654323
35Keratoconjunctivitis sicca (HP:0001097)3.30282192
36Tetraparesis (HP:0002273)3.28595465
37Pulmonary infiltrates (HP:0002113)3.27851023
38Interstitial pulmonary disease (HP:0006530)3.23198416
39Recurrent cutaneous fungal infections (HP:0011370)3.23187453
40Chronic mucocutaneous candidiasis (HP:0002728)3.23187453
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.20593376
42Systemic lupus erythematosus (HP:0002725)3.17071470
43Joint swelling (HP:0001386)3.16239246
44Poikilocytosis (HP:0004447)3.11747598
45Nasal polyposis (HP:0100582)3.10196264
46Conjunctival telangiectasia (HP:0000524)3.05335647
47Abnormality of B cell number (HP:0010975)3.01571132
48Keratoconjunctivitis (HP:0001096)3.00764794
49B lymphocytopenia (HP:0010976)2.99266135
50Hemoptysis (HP:0002105)2.98329661
51Meningitis (HP:0001287)2.90740691
52Abnormality of the common coagulation pathway (HP:0010990)2.90536653
53Cellulitis (HP:0100658)2.89022153
54Obstructive lung disease (HP:0006536)2.86764146
55Chronic obstructive pulmonary disease (HP:0006510)2.86764146
56Abnormality of the nasal mucosa (HP:0000433)2.86310313
57Acanthocytosis (HP:0001927)2.78744835
58Leukocytosis (HP:0001974)2.77947112
59Autoimmune hemolytic anemia (HP:0001890)2.77812292
60Recurrent bronchitis (HP:0002837)2.75504338
61Gingivitis (HP:0000230)2.73262653
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.71979382
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.70125441
64Increased cerebral lipofuscin (HP:0011813)2.68603835
65Gingival bleeding (HP:0000225)2.66333413
66Encephalitis (HP:0002383)2.65612729
67Vertebral compression fractures (HP:0002953)2.64977647
68T lymphocytopenia (HP:0005403)2.62947653
69Vacuolated lymphocytes (HP:0001922)2.62614850
70Thrombocytosis (HP:0001894)2.62147443
71Abnormality of T cells (HP:0002843)2.61616604
72Periodontitis (HP:0000704)2.59567674
73Porencephaly (HP:0002132)2.58446939
74Abnormality of T cell physiology (HP:0011840)2.55705656
75Joint hemorrhage (HP:0005261)2.55312625
76Abnormal pupillary function (HP:0007686)2.54892116
77Prostate neoplasm (HP:0100787)2.54840954
78Gangrene (HP:0100758)2.54268746
79Axonal loss (HP:0003447)2.53842624
80Purpura (HP:0000979)2.53081524
81Severe combined immunodeficiency (HP:0004430)2.52365155
82Eosinophilia (HP:0001880)2.48103711
83Anorexia (HP:0002039)2.47945381
84Agammaglobulinemia (HP:0004432)2.47036768
85Abnormality of the pericardium (HP:0001697)2.44884565
86Petechiae (HP:0000967)2.42099464
87Increased density of long bones (HP:0006392)2.42087884
88Urticaria (HP:0001025)2.39204055
89Chest pain (HP:0100749)2.35702573
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35622046
91Hepatosplenomegaly (HP:0001433)2.33233523
92IgA deficiency (HP:0002720)2.31351577
93Fatigue (HP:0012378)2.26577190
94IgG deficiency (HP:0004315)2.26320147
95Metaphyseal dysplasia (HP:0100255)2.25927979
96Recurrent pneumonia (HP:0006532)2.25699243
97Prolonged neonatal jaundice (HP:0006579)2.25422322
98Peritonitis (HP:0002586)2.23963458
99Chronic sinusitis (HP:0011109)2.23918439
100Decreased central vision (HP:0007663)2.23208676
101Arthralgia (HP:0002829)2.22901440
102Thyroiditis (HP:0100646)2.20979749
103Amyloidosis (HP:0011034)2.18249242
104Abnormality of eosinophils (HP:0001879)2.17886823
105Abnormality of the pleura (HP:0002103)2.16983376
106Recurrent lower respiratory tract infections (HP:0002783)2.16511381
107Abnormality of the heme biosynthetic pathway (HP:0010472)2.16017274
108Osteolytic defects of the phalanges of the hand (HP:0009771)2.15371561
109Osteolytic defects of the hand bones (HP:0009699)2.15371561
110Osteomyelitis (HP:0002754)2.14257689
111Hydroxyprolinuria (HP:0003080)2.13545878
112Abnormality of proline metabolism (HP:0010907)2.13545878
113Abnormality of the prostate (HP:0008775)2.12234596
114Granulocytopenia (HP:0001913)2.10637095
115Panhypogammaglobulinemia (HP:0003139)2.10339246
116Colitis (HP:0002583)2.10105850
117Pulmonary embolism (HP:0002204)2.09198131
118Cleft eyelid (HP:0000625)2.08567527
119Cerebral ischemia (HP:0002637)2.05643666
120Amaurosis fugax (HP:0100576)2.05573982
121Vertigo (HP:0002321)2.05020177
122Progressive visual loss (HP:0000529)2.04783170
123Abnormality of lateral ventricle (HP:0030047)2.02527439
124Paralysis (HP:0003470)2.00258347
125Myocardial infarction (HP:0001658)1.99414035
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99102383
127Epistaxis (HP:0000421)1.97172734
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.94475996
129Pustule (HP:0200039)1.93586411
130Renal cortical cysts (HP:0000803)1.91435308
131Type 2 muscle fiber atrophy (HP:0003554)1.88466194
132Abnormality of the costochondral junction (HP:0000919)1.81480385
133Mucosal telangiectasiae (HP:0100579)1.79095247
134Thrombophlebitis (HP:0004418)1.75901862
135IgM deficiency (HP:0002850)1.73904391
136Mitral stenosis (HP:0001718)1.71936070
137Inflammation of the large intestine (HP:0002037)1.68575283
138Muscle fiber atrophy (HP:0100295)1.68376221
139Combined immunodeficiency (HP:0005387)1.67906098
140Aortic dissection (HP:0002647)1.67116342
141Spontaneous abortion (HP:0005268)1.65702980
142Tinnitus (HP:0000360)1.65540093
143Abnormality of transition element cation homeostasis (HP:0011030)1.65322180
144Abnormality of iron homeostasis (HP:0011031)1.64367095
145Dysostosis multiplex (HP:0000943)1.63591300
146Abnormality of male internal genitalia (HP:0000022)1.61838877
147Hypoproteinemia (HP:0003075)1.61303140
148Facial diplegia (HP:0001349)1.59404808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.54639834
2JAK33.84078156
3TYK23.78301092
4TBK13.60668596
5IKBKB3.16127314
6RIPK42.99456328
7IKBKE2.93594374
8BLK2.86620692
9MYLK2.79702353
10MAP3K132.69618065
11IRAK42.65654339
12MAP4K12.61329346
13JAK12.44669963
14TXK2.43316909
15EIF2AK12.33931200
16MAP4K22.29103840
17PIM22.22477813
18CHUK2.01764581
19ERN11.98400671
20GRK61.94564513
21BMPR21.90564545
22SYK1.80190621
23ARAF1.74077314
24KIT1.71176190
25PTK2B1.68621941
26NME21.60313251
27MAPKAPK31.58322036
28NUAK11.52856955
29GRK51.52734111
30PBK1.52509059
31BTK1.50756694
32IRAK31.49631296
33ZAP701.48850080
34TLK11.45033779
35TEC1.42280356
36MST41.41282261
37FES1.39520164
38MST1R1.35404188
39EIF2AK21.27548102
40TIE11.26441664
41BMX1.23709055
42STK31.22880588
43FRK1.22770324
44ABL21.21896576
45BCR1.21162371
46JAK21.20179114
47LCK1.18051736
48HCK1.17251399
49PIM11.16743740
50MUSK1.09457662
51PTK61.04772383
52LYN1.04634777
53TAOK30.99998801
54TNK20.95202515
55MAP3K110.95146695
56ILK0.93285444
57CSF1R0.90213759
58CSK0.87934074
59EPHB10.82543285
60PLK20.82384482
61TESK10.80358399
62PDK10.77915944
63TRPM70.76551706
64PRKCD0.76064838
65YES10.75232266
66PRKCQ0.73028322
67ITK0.72692631
68DAPK20.72262086
69FGFR30.71765274
70NEK90.70633159
71FGFR40.70114293
72ERBB30.68559218
73DAPK30.68355787
74MAP3K120.67551251
75MAP2K60.66952032
76MOS0.65728216
77LRRK20.65246897
78PKN10.65152935
79MAP3K50.62926057
80ABL10.62579262
81TESK20.60488387
82MAP2K30.59919280
83GRK70.58870922
84MAPKAPK20.57366524
85GRK10.57276245
86FER0.57063169
87MAP3K90.56177777
88EGFR0.55666777
89FGR0.55406390
90ADRBK10.52940312
91IRAK10.52426405
92ADRBK20.51569657
93TNIK0.51551329
94EIF2AK30.50817175
95BMPR1B0.50553869
96RPS6KA40.50190828
97MATK0.49755644
98EPHA30.47827812
99IRAK20.45831392
100MAP3K10.45421959
101PRKD10.43001625
102AKT30.42193885
103STK40.42029893
104STK240.40579175
105MAP2K10.40022623
106SIK30.38876071
107PAK10.38295017
108RPS6KA10.38059253
109NLK0.37610744
110PDPK10.37517777
111SGK20.36373057
112TGFBR20.35846382
113DAPK10.35490975
114ZAK0.34845591
115RET0.32634023
116STK100.32140552
117PIK3CG0.31954155
118MAPK110.31570891
119MAP3K80.30427851
120TGFBR10.29265073
121MAPK120.29199296
122PRKACG0.28899058
123KSR20.28318431
124PRKCH0.26982771
125HIPK20.26476936
126KDR0.26187371
127WNK10.25581229
128FLT30.25397863
129IGF1R0.23675354
130MARK30.23166676
131RPS6KA50.23151921
132CDK120.22688514
133RAF10.21716332
134INSR0.21532752
135CDK40.20997431
136FYN0.19693833
137ACVR1B0.18992511
138TTN0.18755722
139CAMKK20.17258551
140PIK3CA0.17247723
141CDK60.16430783
142SIK20.16365234

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.29689731
2Graft-versus-host disease_Homo sapiens_hsa053324.93285697
3Type I diabetes mellitus_Homo sapiens_hsa049403.65106447
4Autoimmune thyroid disease_Homo sapiens_hsa053203.31576445
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.16680721
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74142389
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.73663749
8Leishmaniasis_Homo sapiens_hsa051402.62033194
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.52403713
10Rheumatoid arthritis_Homo sapiens_hsa053232.47455795
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.44766521
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.33282754
13Measles_Homo sapiens_hsa051622.19744082
14Legionellosis_Homo sapiens_hsa051342.09825951
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00114216
16TNF signaling pathway_Homo sapiens_hsa046681.95128490
17Viral myocarditis_Homo sapiens_hsa054161.91250811
18Asthma_Homo sapiens_hsa053101.90961101
19Pertussis_Homo sapiens_hsa051331.87143376
20Influenza A_Homo sapiens_hsa051641.78786221
21Osteoclast differentiation_Homo sapiens_hsa043801.77630485
22Malaria_Homo sapiens_hsa051441.69967444
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.69937497
24ECM-receptor interaction_Homo sapiens_hsa045121.68343700
25Tuberculosis_Homo sapiens_hsa051521.60019900
26Herpes simplex infection_Homo sapiens_hsa051681.58594212
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.54407393
28Toxoplasmosis_Homo sapiens_hsa051451.53617469
29African trypanosomiasis_Homo sapiens_hsa051431.46981885
30Primary immunodeficiency_Homo sapiens_hsa053401.45860919
31Antigen processing and presentation_Homo sapiens_hsa046121.40742626
32Chemokine signaling pathway_Homo sapiens_hsa040621.40234953
33Sulfur metabolism_Homo sapiens_hsa009201.37350930
34Staphylococcus aureus infection_Homo sapiens_hsa051501.37286047
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32716602
36Apoptosis_Homo sapiens_hsa042101.31637218
37Nitrogen metabolism_Homo sapiens_hsa009101.27443157
38Arachidonic acid metabolism_Homo sapiens_hsa005901.27274236
39Salmonella infection_Homo sapiens_hsa051321.26763032
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21696832
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.17418201
42B cell receptor signaling pathway_Homo sapiens_hsa046621.16146110
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15007503
44Shigellosis_Homo sapiens_hsa051311.14013215
45Hematopoietic cell lineage_Homo sapiens_hsa046401.13357001
46Serotonergic synapse_Homo sapiens_hsa047261.11217389
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09265531
48Hepatitis B_Homo sapiens_hsa051611.00596785
49T cell receptor signaling pathway_Homo sapiens_hsa046600.97380119
50Gap junction_Homo sapiens_hsa045400.94782906
51Phagosome_Homo sapiens_hsa041450.93992796
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88621956
53Focal adhesion_Homo sapiens_hsa045100.83069775
54Hepatitis C_Homo sapiens_hsa051600.81833964
55Glycerolipid metabolism_Homo sapiens_hsa005610.81333188
56Prolactin signaling pathway_Homo sapiens_hsa049170.80543696
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.80106618
58Long-term depression_Homo sapiens_hsa047300.79584754
59Pancreatic secretion_Homo sapiens_hsa049720.75910357
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75524607
61Proteasome_Homo sapiens_hsa030500.75211826
62Alcoholism_Homo sapiens_hsa050340.75069136
63Prion diseases_Homo sapiens_hsa050200.74453949
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74192274
65Amoebiasis_Homo sapiens_hsa051460.74094318
66Endocytosis_Homo sapiens_hsa041440.73350318
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73346238
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73292706
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72237916
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.71295449
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66845607
72Lysosome_Homo sapiens_hsa041420.66818807
73Linoleic acid metabolism_Homo sapiens_hsa005910.66002496
74Acute myeloid leukemia_Homo sapiens_hsa052210.65648945
75Non-small cell lung cancer_Homo sapiens_hsa052230.62875948
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.57125944
77Olfactory transduction_Homo sapiens_hsa047400.56127335
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55989127
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54041422
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53700695
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51691388
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51263945
83Epstein-Barr virus infection_Homo sapiens_hsa051690.50968760
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.50824051
85Chronic myeloid leukemia_Homo sapiens_hsa052200.45862861
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.45621599
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44850732
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44052051
89Platelet activation_Homo sapiens_hsa046110.43351015
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42733151
91Morphine addiction_Homo sapiens_hsa050320.42586956
92Viral carcinogenesis_Homo sapiens_hsa052030.42552826
93p53 signaling pathway_Homo sapiens_hsa041150.42325259
94Rap1 signaling pathway_Homo sapiens_hsa040150.42090310
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42085341
96Renin secretion_Homo sapiens_hsa049240.42042494
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41742068
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41553147
99Renin-angiotensin system_Homo sapiens_hsa046140.39136733
100Systemic lupus erythematosus_Homo sapiens_hsa053220.38741062
101Collecting duct acid secretion_Homo sapiens_hsa049660.37138078
102Melanoma_Homo sapiens_hsa052180.36429934
103Circadian entrainment_Homo sapiens_hsa047130.35629174
104Choline metabolism in cancer_Homo sapiens_hsa052310.35218964
105Oxytocin signaling pathway_Homo sapiens_hsa049210.34312165
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.33170330
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32169922
108Dilated cardiomyopathy_Homo sapiens_hsa054140.31677768
109Cholinergic synapse_Homo sapiens_hsa047250.30126803
110HTLV-I infection_Homo sapiens_hsa051660.28942350
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27808150
112Pancreatic cancer_Homo sapiens_hsa052120.27695676
113Small cell lung cancer_Homo sapiens_hsa052220.27596394
114Type II diabetes mellitus_Homo sapiens_hsa049300.23887333
115HIF-1 signaling pathway_Homo sapiens_hsa040660.22282519
116Other glycan degradation_Homo sapiens_hsa005110.18351570
117Complement and coagulation cascades_Homo sapiens_hsa046100.17980640
118Proteoglycans in cancer_Homo sapiens_hsa052050.17630951
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.14341848
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13859287
121VEGF signaling pathway_Homo sapiens_hsa043700.11968366
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11310065
123Caffeine metabolism_Homo sapiens_hsa002320.08685583
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08288944
125Dorso-ventral axis formation_Homo sapiens_hsa043200.08131441
126Insulin resistance_Homo sapiens_hsa049310.06858939
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06586303
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05368390
129FoxO signaling pathway_Homo sapiens_hsa040680.04847765
130MAPK signaling pathway_Homo sapiens_hsa040100.04231202
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03631283
132ErbB signaling pathway_Homo sapiens_hsa040120.02504071
133Notch signaling pathway_Homo sapiens_hsa043300.01802089
134MicroRNAs in cancer_Homo sapiens_hsa052060.01468543
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.00566781
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0264307
137Ras signaling pathway_Homo sapiens_hsa04014-0.0224193
138Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0207452
139Pentose phosphate pathway_Homo sapiens_hsa00030-0.0102635

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