TNFSF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.31978386
2response to muramyl dipeptide (GO:0032495)5.01267211
3regulation of cytokine secretion involved in immune response (GO:0002739)5.00330183
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93385578
5regulation of vitamin metabolic process (GO:0030656)4.85554441
6positive regulation by symbiont of host defense response (GO:0052509)4.77897748
7modulation by symbiont of host defense response (GO:0052031)4.77897748
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77897748
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77897748
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.77897748
11modulation by symbiont of host immune response (GO:0052553)4.77897748
12activation of MAPKKK activity (GO:0000185)4.75087281
13response to peptidoglycan (GO:0032494)4.73205208
14T-helper 1 type immune response (GO:0042088)4.70348714
15regulation of mononuclear cell migration (GO:0071675)4.40890426
16lipopolysaccharide-mediated signaling pathway (GO:0031663)4.35989276
17positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.32608394
18CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.28916181
19positive regulation of heat generation (GO:0031652)4.25826245
20negative regulation of interleukin-12 production (GO:0032695)4.24378377
21regulation of podosome assembly (GO:0071801)3.99270503
22response to protozoan (GO:0001562)3.95922942
23positive regulation of interferon-alpha production (GO:0032727)3.89535644
24negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.88678062
25regulation of interferon-gamma biosynthetic process (GO:0045072)3.84209630
26regulation of fever generation (GO:0031620)3.81971302
27modulation by symbiont of host cellular process (GO:0044068)3.80672741
28branching involved in labyrinthine layer morphogenesis (GO:0060670)3.80040907
29positive regulation of gamma-delta T cell activation (GO:0046645)3.79064922
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.76439915
31regulation of T-helper 1 cell differentiation (GO:0045625)3.74959839
32cellular response to interferon-beta (GO:0035458)3.74108439
33regulation of interferon-alpha production (GO:0032647)3.74080760
34defense response to protozoan (GO:0042832)3.73818281
35macrophage activation involved in immune response (GO:0002281)3.73441954
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72844533
37positive regulation of chemokine biosynthetic process (GO:0045080)3.67331846
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.67073571
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64547027
40positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.63961792
41regulation of type I interferon-mediated signaling pathway (GO:0060338)3.63629583
42immunoglobulin mediated immune response (GO:0016064)3.61861401
43negative regulation of myeloid cell apoptotic process (GO:0033033)3.60805654
44regulation of chronic inflammatory response (GO:0002676)3.59563299
45granulocyte activation (GO:0036230)3.59516593
46natural killer cell mediated cytotoxicity (GO:0042267)3.55285886
47natural killer cell mediated immunity (GO:0002228)3.55285886
48NIK/NF-kappaB signaling (GO:0038061)3.55045909
49cellular response to virus (GO:0098586)3.54483885
50negative regulation of cytokine production involved in immune response (GO:0002719)3.51725780
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49301909
52negative regulation of lipid storage (GO:0010888)3.47257969
53neutrophil activation (GO:0042119)3.47254642
54monocyte chemotaxis (GO:0002548)3.46660818
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.45781193
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44411695
57B cell mediated immunity (GO:0019724)3.43977474
58cellular response to exogenous dsRNA (GO:0071360)3.39976211
59cellular response to interferon-gamma (GO:0071346)3.37954762
60* positive regulation of interleukin-12 production (GO:0032735)3.35349804
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33822748
62positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.33062138
63regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.31918576
64T cell lineage commitment (GO:0002360)3.29740784
65myeloid cell activation involved in immune response (GO:0002275)3.29541281
66regulation of inflammatory response to antigenic stimulus (GO:0002861)3.28959429
67positive regulation of antigen processing and presentation (GO:0002579)3.28855711
68regulation of activation of Janus kinase activity (GO:0010533)3.28664412
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.25456397
70T cell migration (GO:0072678)3.25249746
71regulation of T-helper cell differentiation (GO:0045622)3.24805130
72cellular response to nicotine (GO:0071316)3.22927006
73positive regulation of lymphocyte apoptotic process (GO:0070230)3.22664589
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22184627
75respiratory burst (GO:0045730)3.22078583
76positive regulation of type 2 immune response (GO:0002830)3.20387031
77positive regulation of monocyte chemotaxis (GO:0090026)3.20096116
78response to interferon-beta (GO:0035456)3.19364233
79positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18321070
80B cell proliferation (GO:0042100)3.18109262
81positive regulation of humoral immune response (GO:0002922)3.17883060
82regulation of interleukin-8 biosynthetic process (GO:0045414)3.15749334
83regulation of heat generation (GO:0031650)3.12793061
84regulation of chemokine biosynthetic process (GO:0045073)3.11548353
85negative regulation of nitric oxide biosynthetic process (GO:0045019)3.09998117
86regulation of interferon-beta biosynthetic process (GO:0045357)3.08851406
87negative regulation of viral genome replication (GO:0045071)3.08570621
88positive regulation of NF-kappaB import into nucleus (GO:0042346)3.08468841
89regulation of B cell receptor signaling pathway (GO:0050855)3.08135979
90regulation of membrane protein ectodomain proteolysis (GO:0051043)3.08014865
91regulation of alpha-beta T cell proliferation (GO:0046640)3.07910129
92interferon-gamma-mediated signaling pathway (GO:0060333)3.07048498
93eosinophil chemotaxis (GO:0048245)3.06197113
94positive regulation of B cell mediated immunity (GO:0002714)3.05950831
95positive regulation of immunoglobulin mediated immune response (GO:0002891)3.05950831
96positive regulation of cellular amide metabolic process (GO:0034250)3.05687519
97response to interferon-gamma (GO:0034341)3.05485921
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05113455
99germinal center formation (GO:0002467)3.05085276
100positive regulation of defense response to virus by host (GO:0002230)3.04716128
101cell adhesion mediated by integrin (GO:0033627)3.04463946
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03099609
103response to host immune response (GO:0052572)3.03099609
104negative regulation of interleukin-17 production (GO:0032700)3.02705398
105positive regulation of interleukin-2 production (GO:0032743)3.00370844
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00089322
107regulation of lymphocyte chemotaxis (GO:1901623)2.99743849
108regulation of immunoglobulin secretion (GO:0051023)2.99525532
109cellular response to molecule of bacterial origin (GO:0071219)2.98819601
110mature B cell differentiation involved in immune response (GO:0002313)2.97892115
111hydrogen peroxide biosynthetic process (GO:0050665)2.97467649
112superoxide anion generation (GO:0042554)2.97428305
113positive regulation of cytokine biosynthetic process (GO:0042108)2.96725931
114negative regulation of amino acid transport (GO:0051956)2.96706395
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.96448580
116regulation of interleukin-2 biosynthetic process (GO:0045076)2.96008614
117regulation of B cell apoptotic process (GO:0002902)2.96001695
118regulation of nitric oxide biosynthetic process (GO:0045428)2.95708612
119wound healing, spreading of epidermal cells (GO:0035313)2.95587298
120negative regulation of T cell mediated immunity (GO:0002710)2.93824834
121positive regulation of nitric oxide biosynthetic process (GO:0045429)2.93616896
122leukocyte mediated cytotoxicity (GO:0001909)2.93567755
123positive regulation of interferon-beta production (GO:0032728)2.93280947
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.92827755
125microglial cell activation (GO:0001774)2.92804291
126* regulation of interleukin-12 production (GO:0032655)2.92510941
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91516126
128regulation of vitamin D biosynthetic process (GO:0060556)2.91131763
129negative regulation of growth of symbiont in host (GO:0044130)2.90466358
130negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.90466358
131modulation of growth of symbiont involved in interaction with host (GO:0044144)2.90466358
132regulation of growth of symbiont in host (GO:0044126)2.90466358
133regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90342912
134positive regulation of interleukin-10 production (GO:0032733)2.89754253
135type I interferon signaling pathway (GO:0060337)2.89610136
136cellular response to type I interferon (GO:0071357)2.89610136
137positive regulation of T-helper cell differentiation (GO:0045624)2.89516135
138positive regulation of B cell proliferation (GO:0030890)2.88498369
139positive regulation of protein homooligomerization (GO:0032464)2.88261614
140detection of molecule of bacterial origin (GO:0032490)2.88138213
141positive regulation of mast cell activation (GO:0033005)2.87204494
142leukocyte aggregation (GO:0070486)2.85990040
143neutrophil mediated immunity (GO:0002446)2.85907296
144* myeloid dendritic cell differentiation (GO:0043011)2.85565513
145positive regulation of mast cell activation involved in immune response (GO:0033008)2.85321939
146positive regulation of mast cell degranulation (GO:0043306)2.85321939
147response to type I interferon (GO:0034340)2.85165239
148positive regulation of lymphocyte migration (GO:2000403)2.84791212
149lymphocyte chemotaxis (GO:0048247)2.84755414
150regulation of NF-kappaB import into nucleus (GO:0042345)2.83590162
151positive regulation of interleukin-1 beta secretion (GO:0050718)2.83458740
152cellular response to lipopolysaccharide (GO:0071222)2.83039464
153positive regulation of T-helper 1 type immune response (GO:0002827)2.82584946
154* myeloid dendritic cell activation (GO:0001773)2.80864585
155regulation of antigen processing and presentation (GO:0002577)2.79742547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.63163253
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.43570940
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.33865121
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.20879303
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.20685374
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.14088422
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.91873311
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.70214479
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.63070091
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60286087
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.54302866
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44285211
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35348665
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18961990
15MYB_21317192_ChIP-Seq_ERMYB_Mouse3.18601359
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13519715
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85143602
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67883510
19MYC_22102868_ChIP-Seq_BL_Human2.59327882
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58638562
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39759246
22SCL_19346495_ChIP-Seq_HPC-7_Human2.20826719
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.14556932
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10506901
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08436459
26VDR_24787735_ChIP-Seq_THP-1_Human2.06095983
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95840600
28* SPI1_23547873_ChIP-Seq_NB4_Human1.93974953
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.92704774
30VDR_24763502_ChIP-Seq_THP-1_Human1.89970001
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89317877
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84368014
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80169377
34ZNF263_19887448_ChIP-Seq_K562_Human1.78808053
35RUNX_20019798_ChIP-Seq_JUKART_Human1.77187148
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.75834050
37PU_27001747_Chip-Seq_BMDM_Mouse1.69948131
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69288143
39SPI1_23127762_ChIP-Seq_K562_Human1.64457668
40MYB_26560356_Chip-Seq_TH2_Human1.61018585
41LXR_22292898_ChIP-Seq_THP-1_Human1.58875732
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57372299
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56188043
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55077457
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50456582
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49174519
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.47859541
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.47376657
49HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47099861
50* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46712395
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46142155
52MAF_26560356_Chip-Seq_TH1_Human1.42969972
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40201417
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37445690
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36350513
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35102564
57MYB_26560356_Chip-Seq_TH1_Human1.34650440
58TFEB_21752829_ChIP-Seq_HELA_Human1.34027667
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30957002
60* KDM2B_26808549_Chip-Seq_DND41_Human1.25703368
61E2F7_22180533_ChIP-Seq_HELA_Human1.24737126
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23855583
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23716597
64VDR_21846776_ChIP-Seq_THP-1_Human1.23308212
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23055693
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22137675
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22117809
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17913013
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17913013
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17648161
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17629996
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15174544
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11895743
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11830853
75GATA3_26560356_Chip-Seq_TH2_Human1.10842620
76RACK7_27058665_Chip-Seq_MCF-7_Human1.10666494
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.09968382
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09917274
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09800385
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09682807
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08632865
82NCOR1_26117541_ChIP-Seq_K562_Human1.08518201
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07811170
84* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07235189
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.06931081
86GATA3_27048872_Chip-Seq_THYMUS_Human1.06857395
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04869184
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04535197
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04461458
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03286218
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02985857
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.01605656
93* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00288214
94* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99481746
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98549965
96* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97340798
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.94713007
98ATF3_27146783_Chip-Seq_COLON_Human0.94089410
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.93832953
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93734997
101* BCOR_27268052_Chip-Seq_Bcells_Human0.93458407
102SOX2_20726797_ChIP-Seq_SW620_Human0.90830719
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90593750
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90515937
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90260801
106CJUN_26792858_Chip-Seq_BT549_Human0.90209185
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89688000
108* UTX_26944678_Chip-Seq_JUKART_Human0.88899420
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88677610
110BCL6_27268052_Chip-Seq_Bcells_Human0.88622924
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88493687
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87825093
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87710132
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87274941
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86316168
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86316168
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85898189
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85126956
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85097640
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84710399
121TCF7_22412390_ChIP-Seq_EML_Mouse0.83921957
122GATA1_22025678_ChIP-Seq_K562_Human0.81608525
123* ELK3_25401928_ChIP-Seq_HUVEC_Human0.80146290
124* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79451285
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79048654
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.76794231
127* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76584298
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.74548832
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73863672
130* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73434790
131MAF_26560356_Chip-Seq_TH2_Human0.72379477
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70665753
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69112121
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64143436
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.63598437
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62810349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.84802437
2MP0003436_decreased_susceptibility_to3.91342214
3MP0002148_abnormal_hypersensitivity_rea3.78845870
4MP0009785_altered_susceptibility_to3.58580794
5MP0006082_CNS_inflammation3.47013857
6MP0005000_abnormal_immune_tolerance3.40104625
7MP0003303_peritoneal_inflammation3.38698556
8MP0002419_abnormal_innate_immunity3.16503170
9MP0005387_immune_system_phenotype2.99750175
10MP0001790_abnormal_immune_system2.99750175
11MP0000685_abnormal_immune_system2.88356384
12MP0005025_abnormal_response_to2.86460068
13MP0005671_abnormal_response_to2.83618638
14MP0002452_abnormal_antigen_presenting2.76690965
15MP0001800_abnormal_humoral_immune2.70479057
16MP0005451_abnormal_body_composition2.65767169
17MP0002723_abnormal_immune_serum2.63468443
18MP0000569_abnormal_digit_pigmentation2.54240990
19MP0004510_myositis2.45851314
20MP0004947_skin_inflammation2.38406415
21* MP0001819_abnormal_immune_cell2.25814121
22* MP0002420_abnormal_adaptive_immunity2.22167406
23MP0005058_abnormal_lysosome_morphology2.16620370
24MP0001853_heart_inflammation2.16297073
25MP0002139_abnormal_hepatobiliary_system2.11165764
26MP0009278_abnormal_bone_marrow2.08520573
27MP0003724_increased_susceptibility_to2.05290960
28MP0003448_altered_tumor_morphology1.98333572
29MP0005464_abnormal_platelet_physiology1.98214314
30MP0009764_decreased_sensitivity_to1.95696794
31MP0001845_abnormal_inflammatory_respons1.87212073
32MP0003172_abnormal_lysosome_physiology1.86337743
33MP0002405_respiratory_system_inflammati1.81131470
34MP0010155_abnormal_intestine_physiology1.80309890
35MP0001533_abnormal_skeleton_physiology1.78902982
36MP0005257_abnormal_intraocular_pressure1.73879525
37MP0002006_tumorigenesis1.72634103
38MP0005310_abnormal_salivary_gland1.62124431
39MP0001545_abnormal_hematopoietic_system1.56320543
40MP0005397_hematopoietic_system_phenotyp1.56320543
41MP0000716_abnormal_immune_system1.56188830
42MP0008004_abnormal_stomach_pH1.55418860
43MP0008469_abnormal_protein_level1.54569715
44MP0005076_abnormal_cell_differentiation1.51878280
45MP0002398_abnormal_bone_marrow1.48710324
46MP0000858_altered_metastatic_potential1.44072619
47MP0000343_altered_response_to1.43188489
48MP0005174_abnormal_tail_pigmentation1.35900457
49MP0009840_abnormal_foam_cell1.30348811
50MP0002254_reproductive_system_inflammat1.29035461
51MP0003453_abnormal_keratinocyte_physiol1.28409448
52MP0001851_eye_inflammation1.26724650
53MP0002998_abnormal_bone_remodeling1.26379907
54MP0002166_altered_tumor_susceptibility1.26375755
55MP0000689_abnormal_spleen_morphology1.25567835
56MP0003690_abnormal_glial_cell1.24320527
57MP0002429_abnormal_blood_cell1.21766328
58MP0009333_abnormal_splenocyte_physiolog1.21517552
59MP0003300_gastrointestinal_ulcer1.15105159
60MP0003806_abnormal_nucleotide_metabolis1.12512504
61MP0000604_amyloidosis1.12466595
62MP0002722_abnormal_immune_system1.11697684
63MP0004782_abnormal_surfactant_physiolog1.11109944
64MP0002877_abnormal_melanocyte_morpholog1.08904926
65MP0003656_abnormal_erythrocyte_physiolo1.06805209
66MP0003566_abnormal_cell_adhesion1.05359261
67MP0005167_abnormal_blood-brain_barrier1.04656044
68MP0003828_pulmonary_edema1.04429713
69MP0009763_increased_sensitivity_to1.03219209
70MP0003075_altered_response_to1.02867450
71MP0003091_abnormal_cell_migration1.02688127
72MP0005166_decreased_susceptibility_to1.01199961
73MP0003183_abnormal_peptide_metabolism0.97265955
74MP0005165_increased_susceptibility_to0.96921382
75MP0002933_joint_inflammation0.94849878
76MP0005164_abnormal_response_to0.94561959
77MP0004381_abnormal_hair_follicle0.91647968
78MP0010307_abnormal_tumor_latency0.91047452
79MP0005390_skeleton_phenotype0.90798381
80MP0001958_emphysema0.89983978
81MP0001348_abnormal_lacrimal_gland0.89321022
82MP0000015_abnormal_ear_pigmentation0.88068997
83MP0001542_abnormal_bone_strength0.87668655
84MP0002138_abnormal_hepatobiliary_system0.86875144
85MP0000249_abnormal_blood_vessel0.82742122
86MP0006054_spinal_hemorrhage0.82232622
87MP0005647_abnormal_sex_gland0.81485926
88MP0008874_decreased_physiological_sensi0.81052429
89MP0002277_abnormal_respiratory_mucosa0.80546640
90MP0005023_abnormal_wound_healing0.79885661
91MP0003763_abnormal_thymus_physiology0.79700780
92MP0000371_diluted_coat_color0.78970201
93MP0008260_abnormal_autophagy0.77025205
94MP0005623_abnormal_meninges_morphology0.76312179
95MP0001873_stomach_inflammation0.72520558
96MP0010352_gastrointestinal_tract_polyps0.71513826
97MP0001727_abnormal_embryo_implantation0.70540390
98MP0009765_abnormal_xenobiotic_induced0.70517856
99MP0005666_abnormal_adipose_tissue0.70014196
100MP0005266_abnormal_metabolism0.69351164
101MP0001663_abnormal_digestive_system0.69141529
102MP0000490_abnormal_crypts_of0.68589389
103MP0003191_abnormal_cellular_cholesterol0.67756756
104MP0004883_abnormal_blood_vessel0.67318125
105MP0003950_abnormal_plasma_membrane0.66346580
106MP0000703_abnormal_thymus_morphology0.64167176
107MP0004808_abnormal_hematopoietic_stem0.63697686
108MP0003795_abnormal_bone_structure0.61592972
109MP0000920_abnormal_myelination0.61578124
110MP0001216_abnormal_epidermal_layer0.59939178
111MP0002019_abnormal_tumor_incidence0.59844189
112MP0005197_abnormal_uvea_morphology0.59835613
113MP0000627_abnormal_mammary_gland0.57796758
114MP0002136_abnormal_kidney_physiology0.57214936
115MP0002693_abnormal_pancreas_physiology0.57169035
116MP0003045_fibrosis0.56720254
117MP0003221_abnormal_cardiomyocyte_apopto0.56261009
118MP0000609_abnormal_liver_physiology0.56049537
119MP0005535_abnormal_body_temperature0.55691086
120MP0001501_abnormal_sleep_pattern0.55317210
121MP0000767_abnormal_smooth_muscle0.54788301
122MP0001191_abnormal_skin_condition0.54403223
123MP0002163_abnormal_gland_morphology0.52637436
124MP0003866_abnormal_defecation0.52391422
125MP0005083_abnormal_biliary_tract0.51198134
126MP0002332_abnormal_exercise_endurance0.50703579

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.53869737
2Recurrent bacterial skin infections (HP:0005406)7.09096018
3Eczematoid dermatitis (HP:0000976)6.24033781
4Elevated erythrocyte sedimentation rate (HP:0003565)5.58372784
5Recurrent gram-negative bacterial infections (HP:0005420)5.37117645
6Stomatitis (HP:0010280)5.36647455
7Gastrointestinal stroma tumor (HP:0100723)5.15655229
8Mediastinal lymphadenopathy (HP:0100721)5.14884640
9Abnormality of macrophages (HP:0004311)4.98028789
10Vacuolated lymphocytes (HP:0001922)4.41462487
11IgA deficiency (HP:0002720)4.40890822
12Thick nail (HP:0001805)4.31924124
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.26381520
14Increased cerebral lipofuscin (HP:0011813)4.17537332
15Recurrent skin infections (HP:0001581)4.13959852
16Gingivitis (HP:0000230)4.08442852
17Optic neuritis (HP:0100653)3.90680002
18Retrobulbar optic neuritis (HP:0100654)3.90680002
19Prostate neoplasm (HP:0100787)3.90318012
20Myositis (HP:0100614)3.83401040
21Systemic lupus erythematosus (HP:0002725)3.82421676
22Orchitis (HP:0100796)3.79973618
23Recurrent fungal infections (HP:0002841)3.64049249
24Pustule (HP:0200039)3.59537345
25Loss of speech (HP:0002371)3.57631732
26Axonal loss (HP:0003447)3.53270369
27Periodontitis (HP:0000704)3.43602612
28Vasculitis (HP:0002633)3.38369984
29Autoimmune thrombocytopenia (HP:0001973)3.23963123
30Nuclear cataract (HP:0100018)3.17877627
31Increased IgM level (HP:0003496)3.17299500
32Chronic obstructive pulmonary disease (HP:0006510)3.16193692
33Obstructive lung disease (HP:0006536)3.16193692
34Lymphopenia (HP:0001888)3.15116287
35Emphysema (HP:0002097)3.11744914
36Abnormality of glycolipid metabolism (HP:0010969)3.10630187
37Abnormality of liposaccharide metabolism (HP:0010968)3.10630187
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.10630187
39Interstitial pulmonary disease (HP:0006530)3.07328485
40Basal ganglia calcification (HP:0002135)3.05037532
41Pulmonary infiltrates (HP:0002113)3.03235298
42Recurrent viral infections (HP:0004429)3.02776390
43Hematochezia (HP:0002573)3.01952167
44Abnormality of cells of the lymphoid lineage (HP:0012140)3.01282665
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.98311203
46Leukocytosis (HP:0001974)2.95946904
47Recurrent sinusitis (HP:0011108)2.88333465
48Recurrent bronchitis (HP:0002837)2.81638918
49Cellulitis (HP:0100658)2.80093834
50Parakeratosis (HP:0001036)2.79055883
51Autoimmune hemolytic anemia (HP:0001890)2.78900124
52Gangrene (HP:0100758)2.78022681
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77517744
54Osteomyelitis (HP:0002754)2.72998180
55Disinhibition (HP:0000734)2.71706511
56Urticaria (HP:0001025)2.69005081
57Amyloidosis (HP:0011034)2.68211042
58Mutism (HP:0002300)2.64062725
59Recurrent cutaneous fungal infections (HP:0011370)2.62566824
60Chronic mucocutaneous candidiasis (HP:0002728)2.62566824
61Increased serum ferritin (HP:0003281)2.59710473
62Anhidrosis (HP:0000970)2.57478246
63Dysostosis multiplex (HP:0000943)2.54212857
64Vertebral compression fractures (HP:0002953)2.53717982
65Hypertensive crisis (HP:0100735)2.53378235
66IgG deficiency (HP:0004315)2.48911775
67Osteolytic defects of the hand bones (HP:0009699)2.48419165
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.48419165
69Glomerulonephritis (HP:0000099)2.45922499
70Premature loss of primary teeth (HP:0006323)2.42363920
71Increased IgE level (HP:0003212)2.41837619
72Meningitis (HP:0001287)2.38639857
73B lymphocytopenia (HP:0010976)2.38449105
74Apathy (HP:0000741)2.37932312
75Gingival bleeding (HP:0000225)2.37873116
76IgM deficiency (HP:0002850)2.35702553
77Abnormality of the prostate (HP:0008775)2.35043929
78Abnormality of the pleura (HP:0002103)2.30291791
79Encephalitis (HP:0002383)2.29613327
80Bone pain (HP:0002653)2.25442363
81Abnormality of B cell number (HP:0010975)2.25026946
82Recurrent pneumonia (HP:0006532)2.24963324
83Progressive neurologic deterioration (HP:0002344)2.23191491
84Diminished motivation (HP:0000745)2.22001763
85Arterial thrombosis (HP:0004420)2.20472808
86Polyneuropathy (HP:0001271)2.20052589
87Pathologic fracture (HP:0002756)2.19893689
88Pulmonary artery stenosis (HP:0004415)2.19217609
89Agnosia (HP:0010524)2.17996683
90Segmental peripheral demyelination/remyelination (HP:0003481)2.17265064
91Hypergammaglobulinemia (HP:0010702)2.16701948
92Hemoptysis (HP:0002105)2.15948962
93Eosinophilia (HP:0001880)2.15275443
94Neurofibrillary tangles (HP:0002185)2.14231729
95Petechiae (HP:0000967)2.11908592
96Keratoconjunctivitis sicca (HP:0001097)2.09835103
97Keratitis (HP:0000491)2.08692597
98Abnormality of the pericardium (HP:0001697)2.05280317
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04922622
100Chronic otitis media (HP:0000389)2.04456074
101Colitis (HP:0002583)2.04052631
102Myocardial infarction (HP:0001658)2.03290550
103Purpura (HP:0000979)2.03053765
104Joint swelling (HP:0001386)2.02384026
105Neuronal loss in central nervous system (HP:0002529)2.01633602
106Cheilitis (HP:0100825)2.00988531
107Mucopolysacchariduria (HP:0008155)1.99967440
108Urinary glycosaminoglycan excretion (HP:0003541)1.99967440
109Abnormality of T cell number (HP:0011839)1.99644413
110Prolonged neonatal jaundice (HP:0006579)1.99639909
111Abnormality of the frontal sinuses (HP:0002687)1.99011946
112Leukopenia (HP:0001882)1.96683397
113Hepatosplenomegaly (HP:0001433)1.95826859
114Gastrointestinal infarctions (HP:0005244)1.95792080
115Thoracolumbar scoliosis (HP:0002944)1.95378281
116Conical tooth (HP:0000698)1.94907033
117Squamous cell carcinoma (HP:0002860)1.94202047
118Inflammation of the large intestine (HP:0002037)1.92847994
119Keratoconjunctivitis (HP:0001096)1.92622365
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92171478
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92171478
122Abnormality of polysaccharide metabolism (HP:0011012)1.92171478
123Agammaglobulinemia (HP:0004432)1.91191626
124Personality changes (HP:0000751)1.91186266
125Nausea (HP:0002018)1.90662206
126Chronic diarrhea (HP:0002028)1.89736532
127Abnormality of T cell physiology (HP:0011840)1.89351223
128Poor head control (HP:0002421)1.89210395
129Anorexia (HP:0002039)1.88845868
130Peripheral demyelination (HP:0011096)1.87661735
131Glomerulopathy (HP:0100820)1.86757183
132Absent frontal sinuses (HP:0002688)1.86562084
133Abnormality of proline metabolism (HP:0010907)1.86177510
134Hydroxyprolinuria (HP:0003080)1.86177510
135Nephritis (HP:0000123)1.85998893
136Tetraparesis (HP:0002273)1.85869580
137Xerostomia (HP:0000217)1.84813361
138Stomach cancer (HP:0012126)1.83031543
139Recurrent lower respiratory tract infections (HP:0002783)1.82895000
140T lymphocytopenia (HP:0005403)1.81829965
141Restrictive lung disease (HP:0002091)1.79962986
142Skin ulcer (HP:0200042)1.79347333
143Arthralgia (HP:0002829)1.79262586
144Abnormality of eosinophils (HP:0001879)1.77913545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.12716782
2TBK13.94976883
3IRAK33.94591881
4RIPK43.23319672
5IKBKB3.19946752
6PRPF4B3.16507185
7IKBKE3.10757802
8IRAK42.94975040
9TYK22.86179865
10JAK32.52510204
11PIM22.47663376
12MAP4K12.41509774
13BMPR22.38723987
14DDR22.36796294
15MAP3K132.34781213
16TXK2.31093306
17KIT2.30034371
18CHUK2.19535507
19JAK11.82446197
20BLK1.76745272
21RIPK11.72514112
22PIM11.62452548
23TLK11.60257001
24MST41.44481764
25MAP3K111.44370127
26NME21.38067389
27EIF2AK21.37430843
28LATS21.34018544
29SMG11.33747340
30CDK121.33013797
31MAP3K31.32930055
32BMX1.32265983
33SYK1.31094116
34PBK1.28681588
35TAOK11.27069051
36TEC1.25963337
37ZAP701.25930087
38TAOK31.20953969
39CSF1R1.18438128
40HCK1.18066933
41ERBB31.17373838
42LCK1.14794692
43CSK1.12964943
44BTK1.12725190
45CDC42BPA1.08643121
46MAP2K31.05880278
47LYN1.03617862
48ABL21.01466217
49JAK20.98269103
50NEK90.95701594
51RPS6KA40.95378972
52TESK20.93538187
53ITK0.92350657
54ICK0.89940472
55TRPM70.89353010
56ERN10.88258443
57SIK30.87514334
58STK100.87330319
59MARK30.83812503
60TGFBR20.81684875
61VRK10.80864941
62PKN10.77533920
63FGR0.76967915
64SIK20.76350875
65MAP3K90.74990840
66BRAF0.73920093
67ABL10.73180782
68MAP3K50.72058000
69CLK10.71663055
70FES0.70515648
71MOS0.70441340
72MAP3K10.69957605
73PRKCD0.69866893
74TTN0.68673798
75HIPK20.68466501
76PDK20.66284376
77ARAF0.65499451
78RPS6KA50.65224485
79IRAK20.62241688
80EGFR0.61683524
81MAP3K80.61202456
82EEF2K0.60229875
83STK40.56725815
84SIK10.56333386
85MAPKAPK20.54866559
86CDK40.53970589
87EPHB10.53177512
88IRAK10.52762155
89TYRO30.52462105
90PTK60.51520127
91DAPK30.51407667
92MAPK110.50816421
93TAOK20.50060750
94BRD40.49707698
95LRRK20.48541102
96MST1R0.47923387
97CDK60.47413879
98EIF2AK30.47171493
99MAP3K100.45200943
100YES10.43338021
101AURKA0.42852192
102PRKCQ0.41834459
103MAPK70.41793261
104FLT30.40307973
105GRK70.39883356
106DYRK30.38801185
107RPS6KA60.38151828
108FGFR30.38022816
109TESK10.37747533
110RPS6KA20.36710024
111CCNB10.35931294
112DYRK1B0.35921450
113MATK0.35509372
114TRIB30.34841535
115PLK20.34512632
116PDGFRB0.32917484
117GSK3A0.32328401
118RPS6KA10.31095974
119MELK0.30028507
120PAK40.29487183
121STK240.29473465
122RPS6KL10.26918435
123RPS6KC10.26918435
124FYN0.25128747
125ZAK0.24941495
126PAK10.24524202
127PDK10.23577911
128STK30.23210168
129MAPK40.22490986
130INSR0.21804665
131IGF1R0.21155482
132PIK3CA0.20141785
133FGFR40.20091280
134SGK10.19255440
135ADRBK20.18681215
136SCYL20.18110289

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.90629907
2Allograft rejection_Homo sapiens_hsa053303.18121122
3Leishmaniasis_Homo sapiens_hsa051403.12428314
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.92231845
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.91543200
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.88635519
7Rheumatoid arthritis_Homo sapiens_hsa053232.53755738
8Legionellosis_Homo sapiens_hsa051342.44581508
9Osteoclast differentiation_Homo sapiens_hsa043802.44166034
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36705101
11Staphylococcus aureus infection_Homo sapiens_hsa051502.36475956
12Pertussis_Homo sapiens_hsa051332.33945051
13Type I diabetes mellitus_Homo sapiens_hsa049402.32751641
14Malaria_Homo sapiens_hsa051442.29424462
15TNF signaling pathway_Homo sapiens_hsa046682.23211600
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21650053
17Asthma_Homo sapiens_hsa053102.18470963
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08661228
19Tuberculosis_Homo sapiens_hsa051522.05810415
20Measles_Homo sapiens_hsa051621.95010867
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.80833324
22African trypanosomiasis_Homo sapiens_hsa051431.75518056
23Influenza A_Homo sapiens_hsa051641.72354997
24B cell receptor signaling pathway_Homo sapiens_hsa046621.69320248
25Apoptosis_Homo sapiens_hsa042101.66709088
26Hematopoietic cell lineage_Homo sapiens_hsa046401.64383882
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63662331
28Lysosome_Homo sapiens_hsa041421.63250366
29Salmonella infection_Homo sapiens_hsa051321.52057319
30Autoimmune thyroid disease_Homo sapiens_hsa053201.51711142
31* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50912643
32Toxoplasmosis_Homo sapiens_hsa051451.50378608
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45946250
34Herpes simplex infection_Homo sapiens_hsa051681.41378486
35Phagosome_Homo sapiens_hsa041451.41329848
36Other glycan degradation_Homo sapiens_hsa005111.32365641
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.31578252
38Shigellosis_Homo sapiens_hsa051311.30865934
39Antigen processing and presentation_Homo sapiens_hsa046121.30475739
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25520838
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22556608
42Viral myocarditis_Homo sapiens_hsa054161.20312618
43Chemokine signaling pathway_Homo sapiens_hsa040621.20030906
44Hepatitis B_Homo sapiens_hsa051611.17345318
45T cell receptor signaling pathway_Homo sapiens_hsa046601.14902185
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11218390
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11036126
48Hepatitis C_Homo sapiens_hsa051600.99658302
49Amoebiasis_Homo sapiens_hsa051460.96096243
50Primary immunodeficiency_Homo sapiens_hsa053400.95417113
51Bladder cancer_Homo sapiens_hsa052190.95120502
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93940549
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.90432649
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87695350
55Alcoholism_Homo sapiens_hsa050340.77794094
56Chronic myeloid leukemia_Homo sapiens_hsa052200.72535486
57Prion diseases_Homo sapiens_hsa050200.72184108
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.71771899
59Type II diabetes mellitus_Homo sapiens_hsa049300.67064968
60Small cell lung cancer_Homo sapiens_hsa052220.65801187
61Acute myeloid leukemia_Homo sapiens_hsa052210.64904347
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.62527600
63Epstein-Barr virus infection_Homo sapiens_hsa051690.61637361
64Fructose and mannose metabolism_Homo sapiens_hsa000510.61061881
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60377708
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57732844
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56839756
68Collecting duct acid secretion_Homo sapiens_hsa049660.54515171
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53697671
70Pancreatic cancer_Homo sapiens_hsa052120.51178601
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.49346049
72Prolactin signaling pathway_Homo sapiens_hsa049170.47977079
73HTLV-I infection_Homo sapiens_hsa051660.42663114
74Platelet activation_Homo sapiens_hsa046110.42359263
75Complement and coagulation cascades_Homo sapiens_hsa046100.40760882
76Galactose metabolism_Homo sapiens_hsa000520.39793481
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39347303
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37258762
79Viral carcinogenesis_Homo sapiens_hsa052030.36773268
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.35620839
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34588462
82Proteoglycans in cancer_Homo sapiens_hsa052050.34525833
83Pentose phosphate pathway_Homo sapiens_hsa000300.33109511
84MicroRNAs in cancer_Homo sapiens_hsa052060.31780506
85Insulin resistance_Homo sapiens_hsa049310.31517735
86Sphingolipid metabolism_Homo sapiens_hsa006000.31371005
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31109828
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30663435
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30648643
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27941199
91HIF-1 signaling pathway_Homo sapiens_hsa040660.26925115
92VEGF signaling pathway_Homo sapiens_hsa043700.26127034
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25175009
94Folate biosynthesis_Homo sapiens_hsa007900.23055750
95p53 signaling pathway_Homo sapiens_hsa041150.22612485
96Sulfur metabolism_Homo sapiens_hsa009200.22577638
97FoxO signaling pathway_Homo sapiens_hsa040680.20944162
98Notch signaling pathway_Homo sapiens_hsa043300.18880489
99Prostate cancer_Homo sapiens_hsa052150.17612798
100Mineral absorption_Homo sapiens_hsa049780.14313368
101MAPK signaling pathway_Homo sapiens_hsa040100.13275128
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12857117
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11668983
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10118142
105Vibrio cholerae infection_Homo sapiens_hsa051100.09202694
106Systemic lupus erythematosus_Homo sapiens_hsa053220.08292406
107mTOR signaling pathway_Homo sapiens_hsa041500.08143127
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.08057162
109Arachidonic acid metabolism_Homo sapiens_hsa005900.06549587
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06272775
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05548178
112Sulfur relay system_Homo sapiens_hsa041220.01386238

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