TNIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03437514
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.03437514
3antigen processing and presentation of endogenous antigen (GO:0019883)5.02602851
4positive regulation of gamma-delta T cell activation (GO:0046645)5.01483587
5NIK/NF-kappaB signaling (GO:0038061)4.80551475
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.71197260
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.71197260
8modulation by symbiont of host immune response (GO:0052553)4.71197260
9positive regulation by symbiont of host defense response (GO:0052509)4.71197260
10modulation by symbiont of host defense response (GO:0052031)4.71197260
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.71197260
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64958931
13regulation of vitamin D biosynthetic process (GO:0060556)4.34798488
14regulation of interleukin-12 biosynthetic process (GO:0045075)4.18536475
15response to muramyl dipeptide (GO:0032495)4.18010910
16response to peptidoglycan (GO:0032494)4.12226567
17immunoglobulin mediated immune response (GO:0016064)3.94521319
18regulation of gamma-delta T cell activation (GO:0046643)3.82091206
19neutrophil activation involved in immune response (GO:0002283)3.79601604
20macrophage activation involved in immune response (GO:0002281)3.67905116
21regulation of gamma-delta T cell differentiation (GO:0045586)3.67867287
22regulation of vitamin metabolic process (GO:0030656)3.63433321
23negative regulation of interleukin-12 production (GO:0032695)3.62088568
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55824454
25positive regulation of chemokine biosynthetic process (GO:0045080)3.54319418
26leukocyte aggregation (GO:0070486)3.48816272
27positive regulation of interferon-alpha production (GO:0032727)3.47547019
28response to type I interferon (GO:0034340)3.47083320
29interferon-gamma-mediated signaling pathway (GO:0060333)3.45292349
30type I interferon signaling pathway (GO:0060337)3.45002611
31cellular response to type I interferon (GO:0071357)3.45002611
32positive regulation of antigen processing and presentation (GO:0002579)3.42033849
33positive regulation of heat generation (GO:0031652)3.41338083
34regulation of interferon-alpha production (GO:0032647)3.38194818
35JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.36461905
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35337114
37regulation of cytokine secretion involved in immune response (GO:0002739)3.31346649
38myeloid dendritic cell differentiation (GO:0043011)3.30996566
39regulation of interferon-beta biosynthetic process (GO:0045357)3.26562292
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26512920
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25330362
42negative regulation of cytokine production involved in immune response (GO:0002719)3.25316022
43positive thymic T cell selection (GO:0045059)3.23969631
44detection of other organism (GO:0098543)3.23393135
45regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16129775
46respiratory burst (GO:0045730)3.15874465
47detection of bacterium (GO:0016045)3.13858249
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11421422
49response to host immune response (GO:0052572)3.11421422
50B cell mediated immunity (GO:0019724)3.11225195
51regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06304984
52positive regulation of type 2 immune response (GO:0002830)3.05800659
53granulocyte activation (GO:0036230)3.05694643
54positive regulation of interferon-beta production (GO:0032728)3.05384155
55myeloid dendritic cell activation (GO:0001773)3.04294513
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02682179
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.01904493
58regulation of fever generation (GO:0031620)2.96780095
59regulation of response to interferon-gamma (GO:0060330)2.96517569
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95769939
61response to host (GO:0075136)2.95769939
62response to host defenses (GO:0052200)2.95769939
63cellular response to zinc ion (GO:0071294)2.94970202
64* leukocyte cell-cell adhesion (GO:0007159)2.94614606
65antigen processing and presentation via MHC class Ib (GO:0002475)2.94538700
66regulation of chemokine biosynthetic process (GO:0045073)2.93539388
67detection of molecule of bacterial origin (GO:0032490)2.93429511
68negative regulation of erythrocyte differentiation (GO:0045647)2.92901360
69neutrophil activation (GO:0042119)2.92647652
70regulation of membrane protein ectodomain proteolysis (GO:0051043)2.92394202
71regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.92340687
72natural killer cell mediated cytotoxicity (GO:0042267)2.90134515
73natural killer cell mediated immunity (GO:0002228)2.90134515
74regulation of T-helper 2 cell differentiation (GO:0045628)2.89430125
75regulation of antigen processing and presentation (GO:0002577)2.89049366
76positive regulation of B cell differentiation (GO:0045579)2.85535299
77negative regulation of myeloid cell apoptotic process (GO:0033033)2.85100568
78detection of external biotic stimulus (GO:0098581)2.84813356
79regulation of podosome assembly (GO:0071801)2.84793604
80low-density lipoprotein particle clearance (GO:0034383)2.84336565
81regulation of interleukin-12 production (GO:0032655)2.84249459
82negative regulation of cell killing (GO:0031342)2.84047211
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84047211
84negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83744513
85positive regulation of interleukin-12 production (GO:0032735)2.83220426
86positive regulation of natural killer cell differentiation (GO:0032825)2.81813765
87T cell migration (GO:0072678)2.81776852
88positive regulation of NF-kappaB import into nucleus (GO:0042346)2.81069577
89regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.80373002
90tolerance induction (GO:0002507)2.79999178
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79949956
92positive regulation of humoral immune response (GO:0002922)2.79150645
93defense response to protozoan (GO:0042832)2.79142321
94germinal center formation (GO:0002467)2.78371204
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77173820
96activation of MAPKKK activity (GO:0000185)2.76494356
97myeloid cell activation involved in immune response (GO:0002275)2.75487807
98regulation of T-helper 1 cell differentiation (GO:0045625)2.75323399
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74829331
100regulation of chronic inflammatory response (GO:0002676)2.74516124
101cellular response to interferon-gamma (GO:0071346)2.73937495
102negative thymic T cell selection (GO:0045060)2.73711279
103regulation of cholesterol storage (GO:0010885)2.73400939
104hydrogen peroxide biosynthetic process (GO:0050665)2.73248177
105positive regulation of cytokine biosynthetic process (GO:0042108)2.73231703
106regulation of B cell receptor signaling pathway (GO:0050855)2.72343725
107cellular response to lipopolysaccharide (GO:0071222)2.71549987
108regulation of T cell tolerance induction (GO:0002664)2.71303843
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70463921
110cellular response to virus (GO:0098586)2.69934345
111regulation of mononuclear cell migration (GO:0071675)2.68690115
112regulation of type 2 immune response (GO:0002828)2.67749175
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.67347880
114cellular response to molecule of bacterial origin (GO:0071219)2.66893160
115dendritic cell differentiation (GO:0097028)2.66779348
116T-helper 1 type immune response (GO:0042088)2.65534338
117positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.64280944
118regulation of integrin activation (GO:0033623)2.64055321
119response to protozoan (GO:0001562)2.63052467
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.62749187
121negative T cell selection (GO:0043383)2.62593057
122regulation of interleukin-2 biosynthetic process (GO:0045076)2.62529584
123cytokine secretion (GO:0050663)2.62327012
124positive regulation of interleukin-2 production (GO:0032743)2.62215769
125cellular response to interferon-beta (GO:0035458)2.61013891
126response to interferon-gamma (GO:0034341)2.60518041
127regulation of alpha-beta T cell proliferation (GO:0046640)2.59960216
128protein localization to endosome (GO:0036010)2.59779473
129negative regulation of lipid storage (GO:0010888)2.58592875
130negative regulation of T cell mediated immunity (GO:0002710)2.58136347
131regulation of interferon-gamma biosynthetic process (GO:0045072)2.57804786
132positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.57481327
133negative regulation of production of molecular mediator of immune response (GO:0002701)2.57133583
134mature B cell differentiation involved in immune response (GO:0002313)2.56344433
135macrophage activation (GO:0042116)2.56299189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89996107
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.33012407
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.91737499
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.60479612
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51533806
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22743973
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22020314
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04208342
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01772107
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92396549
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.88004122
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76853148
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75724084
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.75415278
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.70933342
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58958850
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39728266
18MYC_22102868_ChIP-Seq_BL_Human2.35330782
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30951827
20VDR_21846776_ChIP-Seq_THP-1_Human2.29701867
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28645951
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27179859
23* MAF_26560356_Chip-Seq_TH1_Human2.09558595
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09480497
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08679601
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03842585
27VDR_24763502_ChIP-Seq_THP-1_Human1.89252394
28MYB_26560356_Chip-Seq_TH2_Human1.87988131
29* SPI1_23547873_ChIP-Seq_NB4_Human1.81405729
30TCF7_22412390_ChIP-Seq_EML_Mouse1.80709447
31* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78375373
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.77371279
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73601971
34UTX_26944678_Chip-Seq_JUKART_Human1.72763722
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.72482157
36RUNX_20019798_ChIP-Seq_JUKART_Human1.71488151
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68221938
38* MYB_26560356_Chip-Seq_TH1_Human1.67004143
39SPI1_23127762_ChIP-Seq_K562_Human1.65689819
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64793383
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57591598
42SCL_19346495_ChIP-Seq_HPC-7_Human1.57561826
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56825291
44* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51585027
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50066934
46KDM2B_26808549_Chip-Seq_DND41_Human1.46936244
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43995857
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41743066
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41470919
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.32668816
51MAF_26560356_Chip-Seq_TH2_Human1.32298306
52GATA1_22025678_ChIP-Seq_K562_Human1.32221811
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31871684
54* PU_27001747_Chip-Seq_BMDM_Mouse1.29773346
55* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29512048
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27236167
57* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23964756
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20465032
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19314772
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16130239
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16108812
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15813263
63E2F7_22180533_ChIP-Seq_HELA_Human1.15426671
64* GATA1_19941826_ChIP-Seq_K562_Human1.15386019
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14402195
66* GATA3_27048872_Chip-Seq_THYMUS_Human1.14116624
67LXR_22292898_ChIP-Seq_THP-1_Human1.11551297
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.10238340
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09927431
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08990354
71KDM2B_26808549_Chip-Seq_K562_Human1.07862570
72TFEB_21752829_ChIP-Seq_HELA_Human1.07309624
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.07199164
74RACK7_27058665_Chip-Seq_MCF-7_Human1.06296273
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05791404
76* NCOR1_26117541_ChIP-Seq_K562_Human1.04563785
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04353394
78* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04101845
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03884087
80VDR_24787735_ChIP-Seq_THP-1_Human1.02918734
81ATF3_27146783_Chip-Seq_COLON_Human1.02185111
82* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01178990
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01072919
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00957150
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99832589
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.99210750
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98934431
88* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98858254
89* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98319246
90* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98021260
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97913096
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97752374
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97333216
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96969464
95* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96829694
96BCOR_27268052_Chip-Seq_Bcells_Human0.96349424
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96235725
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95423780
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95341281
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95046367
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.93632090
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93072512
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92556670
104* BCL6_27268052_Chip-Seq_Bcells_Human0.90759736
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89785553
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89432098
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.88545949
108CLOCK_20551151_ChIP-Seq_293T_Human0.87881548
109* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85884191
110FOXM1_23109430_ChIP-Seq_U2OS_Human0.85730557
111GATA3_26560356_Chip-Seq_TH2_Human0.85359170
112* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84244407
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84180825
114* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83451295
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82594143
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82594143
117* ESR2_21235772_ChIP-Seq_MCF-7_Human0.81932626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.62809193
2MP0003303_peritoneal_inflammation3.33579672
3MP0000685_abnormal_immune_system3.30376025
4MP0003436_decreased_susceptibility_to3.14830802
5MP0009785_altered_susceptibility_to3.12350972
6MP0004510_myositis2.86222781
7MP0005387_immune_system_phenotype2.76340363
8MP0001790_abnormal_immune_system2.76340363
9MP0005000_abnormal_immune_tolerance2.70575667
10MP0006082_CNS_inflammation2.69704075
11MP0002254_reproductive_system_inflammat2.68019542
12MP0005025_abnormal_response_to2.50251500
13MP0002148_abnormal_hypersensitivity_rea2.49655165
14MP0005451_abnormal_body_composition2.49084989
15MP0001800_abnormal_humoral_immune2.48387270
16MP0002419_abnormal_innate_immunity2.45464897
17MP0005671_abnormal_response_to2.45374920
18MP0009278_abnormal_bone_marrow2.42720950
19MP0002452_abnormal_antigen_presenting2.39172778
20MP0004947_skin_inflammation2.32281609
21MP0002723_abnormal_immune_serum2.28944431
22MP0003724_increased_susceptibility_to2.22634929
23MP0001819_abnormal_immune_cell2.11020237
24MP0002420_abnormal_adaptive_immunity2.09088327
25MP0010155_abnormal_intestine_physiology1.99608481
26MP0002405_respiratory_system_inflammati1.96331382
27MP0003300_gastrointestinal_ulcer1.90888461
28MP0002139_abnormal_hepatobiliary_system1.87956660
29MP0003763_abnormal_thymus_physiology1.84744746
30MP0005058_abnormal_lysosome_morphology1.83583880
31MP0009333_abnormal_splenocyte_physiolog1.81358366
32MP0010352_gastrointestinal_tract_polyps1.78676219
33MP0005464_abnormal_platelet_physiology1.76770946
34MP0005397_hematopoietic_system_phenotyp1.75786350
35MP0001545_abnormal_hematopoietic_system1.75786350
36MP0003448_altered_tumor_morphology1.73965216
37MP0001845_abnormal_inflammatory_respons1.73557907
38MP0002398_abnormal_bone_marrow1.70921006
39MP0001873_stomach_inflammation1.70224816
40MP0005076_abnormal_cell_differentiation1.69875659
41MP0001533_abnormal_skeleton_physiology1.68729938
42MP0001853_heart_inflammation1.67559326
43MP0000716_abnormal_immune_system1.65747463
44MP0002006_tumorigenesis1.61576339
45MP0000343_altered_response_to1.57599961
46MP0002166_altered_tumor_susceptibility1.54987763
47MP0005310_abnormal_salivary_gland1.52702975
48MP0009840_abnormal_foam_cell1.51256174
49MP0003566_abnormal_cell_adhesion1.45505318
50MP0003172_abnormal_lysosome_physiology1.41298176
51MP0000689_abnormal_spleen_morphology1.40268610
52MP0002722_abnormal_immune_system1.39454770
53MP0000858_altered_metastatic_potential1.38126017
54MP0010307_abnormal_tumor_latency1.37835228
55MP0003453_abnormal_keratinocyte_physiol1.36859150
56* MP0002429_abnormal_blood_cell1.36215254
57MP0008004_abnormal_stomach_pH1.34517898
58MP0008469_abnormal_protein_level1.33403143
59MP0003828_pulmonary_edema1.30854115
60MP0003705_abnormal_hypodermis_morpholog1.27382497
61MP0008260_abnormal_autophagy1.27204177
62MP0009764_decreased_sensitivity_to1.25226463
63MP0005023_abnormal_wound_healing1.21576006
64MP0003656_abnormal_erythrocyte_physiolo1.19532842
65MP0003866_abnormal_defecation1.16224643
66MP0002998_abnormal_bone_remodeling1.11727986
67MP0003075_altered_response_to1.11537609
68MP0003806_abnormal_nucleotide_metabolis1.11321482
69MP0000703_abnormal_thymus_morphology1.08479170
70MP0004808_abnormal_hematopoietic_stem1.07185390
71MP0002933_joint_inflammation1.05813434
72MP0003191_abnormal_cellular_cholesterol1.05379216
73MP0005167_abnormal_blood-brain_barrier1.03748230
74MP0000490_abnormal_crypts_of1.02832316
75MP0002138_abnormal_hepatobiliary_system1.02608633
76MP0001348_abnormal_lacrimal_gland0.99464511
77MP0003091_abnormal_cell_migration0.98598235
78MP0001851_eye_inflammation0.97827828
79MP0000604_amyloidosis0.97404488
80MP0003690_abnormal_glial_cell0.96657103
81MP0002396_abnormal_hematopoietic_system0.93644036
82MP0006054_spinal_hemorrhage0.91818717
83MP0002877_abnormal_melanocyte_morpholog0.88287630
84MP0005666_abnormal_adipose_tissue0.85467308
85MP0002277_abnormal_respiratory_mucosa0.84948163
86MP0004858_abnormal_nervous_system0.84669949
87MP0005166_decreased_susceptibility_to0.83710826
88MP0003045_fibrosis0.83572776
89MP0003183_abnormal_peptide_metabolism0.82175036
90MP0008874_decreased_physiological_sensi0.79415516
91MP0005165_increased_susceptibility_to0.78615644
92MP0004883_abnormal_blood_vessel0.78514785
93MP0005390_skeleton_phenotype0.78504108
94MP0009763_increased_sensitivity_to0.78046049
95MP0000733_abnormal_muscle_development0.77047845
96MP0000249_abnormal_blood_vessel0.74356476
97MP0009765_abnormal_xenobiotic_induced0.73919078
98MP0000465_gastrointestinal_hemorrhage0.70558989
99MP0002019_abnormal_tumor_incidence0.69607088
100MP0003329_amyloid_beta_deposits0.69134714
101MP0000750_abnormal_muscle_regeneration0.68552889
102MP0004185_abnormal_adipocyte_glucose0.68425239
103MP0000569_abnormal_digit_pigmentation0.68134374
104MP0003221_abnormal_cardiomyocyte_apopto0.68004840
105MP0001542_abnormal_bone_strength0.67721537
106MP0000371_diluted_coat_color0.67459803
107MP0003646_muscle_fatigue0.66675932
108MP0003279_aneurysm0.64342899
109MP0001849_ear_inflammation0.62917721
110MP0002332_abnormal_exercise_endurance0.62612486
111MP0005164_abnormal_response_to0.62378577
112MP0001663_abnormal_digestive_system0.61907597
113MP0002136_abnormal_kidney_physiology0.61582307
114MP0003795_abnormal_bone_structure0.60857129
115MP0004782_abnormal_surfactant_physiolog0.58963009
116MP0005621_abnormal_cell_physiology0.56072010

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.19262504
2Recurrent abscess formation (HP:0002722)5.68024809
3Elevated erythrocyte sedimentation rate (HP:0003565)5.22465188
4Recurrent bacterial skin infections (HP:0005406)5.01548075
5Stomatitis (HP:0010280)4.65060805
6Myositis (HP:0100614)4.46581304
7Recurrent fungal infections (HP:0002841)4.36466689
8Mediastinal lymphadenopathy (HP:0100721)4.28643034
9Abnormality of macrophages (HP:0004311)4.22916624
10Orchitis (HP:0100796)4.12653246
11Recurrent gram-negative bacterial infections (HP:0005420)3.99721690
12Autoimmune thrombocytopenia (HP:0001973)3.98655868
13Pustule (HP:0200039)3.89666095
14Retrobulbar optic neuritis (HP:0100654)3.83313625
15Optic neuritis (HP:0100653)3.83313625
16Recurrent skin infections (HP:0001581)3.60258262
17Chronic mucocutaneous candidiasis (HP:0002728)3.58334317
18Recurrent cutaneous fungal infections (HP:0011370)3.58334317
19Recurrent viral infections (HP:0004429)3.54024887
20Gingivitis (HP:0000230)3.48733648
21Interstitial pulmonary disease (HP:0006530)3.25353317
22Vasculitis (HP:0002633)3.24248566
23Chronic otitis media (HP:0000389)3.20376104
24Increased cerebral lipofuscin (HP:0011813)3.18590659
25Loss of speech (HP:0002371)3.11618671
26Nasal polyposis (HP:0100582)3.09201569
27Obstructive lung disease (HP:0006536)3.02226031
28Chronic obstructive pulmonary disease (HP:0006510)3.02226031
29Abnormality of the nasal mucosa (HP:0000433)2.89865365
30Cellulitis (HP:0100658)2.87969064
31Keratoconjunctivitis (HP:0001096)2.84699763
32Pulmonary infiltrates (HP:0002113)2.82450688
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.71221192
34Arterial thrombosis (HP:0004420)2.68783704
35Increased IgE level (HP:0003212)2.65673767
36Leukocytosis (HP:0001974)2.64516606
37Urticaria (HP:0001025)2.63950369
38Vacuolated lymphocytes (HP:0001922)2.61367934
39Periodontitis (HP:0000704)2.60445359
40Amyloidosis (HP:0011034)2.59389872
41Colitis (HP:0002583)2.59248076
42Disinhibition (HP:0000734)2.58100823
43Increased IgM level (HP:0003496)2.53486513
44Recurrent bronchitis (HP:0002837)2.50594032
45Hematochezia (HP:0002573)2.49838042
46Inflammation of the large intestine (HP:0002037)2.47727920
47Meningitis (HP:0001287)2.47218124
48Emphysema (HP:0002097)2.44104621
49Gastrointestinal inflammation (HP:0004386)2.43120654
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.42942492
51Axonal loss (HP:0003447)2.42476714
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40031766
53Abnormality of polysaccharide metabolism (HP:0011012)2.40031766
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40031766
55Nuclear cataract (HP:0100018)2.39648150
56Hemoptysis (HP:0002105)2.38608111
57Tetraparesis (HP:0002273)2.38155000
58Keratoconjunctivitis sicca (HP:0001097)2.37992742
59Glomerulonephritis (HP:0000099)2.37974917
60Gangrene (HP:0100758)2.36527566
61Abnormality of T cell number (HP:0011839)2.35848342
62Neurofibrillary tangles (HP:0002185)2.35399419
63Malnutrition (HP:0004395)2.33133573
64Hypergammaglobulinemia (HP:0010702)2.30520385
65Myocardial infarction (HP:0001658)2.26823638
66Premature loss of primary teeth (HP:0006323)2.26528087
67Purpura (HP:0000979)2.26493974
68Basal ganglia calcification (HP:0002135)2.25388730
69Abnormality of T cells (HP:0002843)2.24486870
70T lymphocytopenia (HP:0005403)2.24208809
71Encephalitis (HP:0002383)2.23879386
72Gastrointestinal stroma tumor (HP:0100723)2.23570498
73Osteomyelitis (HP:0002754)2.22444029
74Frequent falls (HP:0002359)2.17171056
75Vertebral compression fractures (HP:0002953)2.15998599
76Thick nail (HP:0001805)2.15881045
77Thin bony cortex (HP:0002753)2.13865769
78Gastrointestinal infarctions (HP:0005244)2.13349639
79Abnormality of T cell physiology (HP:0011840)2.13270855
80Thrombocytosis (HP:0001894)2.09472998
81Asymmetric septal hypertrophy (HP:0001670)2.07954786
82Eosinophilia (HP:0001880)2.06624546
83Cerebral inclusion bodies (HP:0100314)2.06223696
84Skin ulcer (HP:0200042)2.04523821
85Dysostosis multiplex (HP:0000943)2.03218061
86IgM deficiency (HP:0002850)2.02651868
87Cheilitis (HP:0100825)2.02578978
88Chest pain (HP:0100749)2.01843775
89IgA deficiency (HP:0002720)2.01583328
90Restrictive lung disease (HP:0002091)2.01329736
91Spontaneous hematomas (HP:0007420)2.00483014
92Segmental peripheral demyelination/remyelination (HP:0003481)1.99605048
93Abnormality of iron homeostasis (HP:0011031)1.98161668
94Hypertensive crisis (HP:0100735)1.94156680
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.93944790
96Abnormality of liposaccharide metabolism (HP:0010968)1.93349856
97Abnormality of glycosphingolipid metabolism (HP:0004343)1.93349856
98Abnormality of glycolipid metabolism (HP:0010969)1.93349856
99Hepatosplenomegaly (HP:0001433)1.93256171
100Abnormality of complement system (HP:0005339)1.92960589
101Gingival bleeding (HP:0000225)1.92785502
102Prostate neoplasm (HP:0100787)1.92622056
103Abnormality of the pleura (HP:0002103)1.91500682
104Pulmonary embolism (HP:0002204)1.91216333
105Lymphopenia (HP:0001888)1.91077545
106Glomerulopathy (HP:0100820)1.90665035
107Abnormality of the fingertips (HP:0001211)1.90480334
108Petechiae (HP:0000967)1.90271812
109Esophageal varix (HP:0002040)1.87844479
110Urinary glycosaminoglycan excretion (HP:0003541)1.87642819
111Mucopolysacchariduria (HP:0008155)1.87642819
112Anorexia (HP:0002039)1.87571916
113Panhypogammaglobulinemia (HP:0003139)1.86482061
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.85516374
115Osteolytic defects of the hand bones (HP:0009699)1.85516374
116Mutism (HP:0002300)1.85327998
117Complement deficiency (HP:0004431)1.85011012
118Neuronal loss in central nervous system (HP:0002529)1.85001628
119Persistence of primary teeth (HP:0006335)1.84367303
120Polyneuropathy (HP:0001271)1.83393156
121Increased serum ferritin (HP:0003281)1.82445275
122Polygenic inheritance (HP:0010982)1.82380425
123Joint swelling (HP:0001386)1.81855223
124Abnormality of the pericardium (HP:0001697)1.81776650
125Arthralgia (HP:0002829)1.81708268
126Systemic lupus erythematosus (HP:0002725)1.81591457
127Autoimmune hemolytic anemia (HP:0001890)1.80031476
128Abnormality of eosinophils (HP:0001879)1.79362951
129Recurrent lower respiratory tract infections (HP:0002783)1.79077954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.00011990
2MAP4K13.57644433
3TBK13.42330072
4PRPF4B3.12350844
5TYK22.85833889
6JAK32.79889029
7IRAK32.72572937
8IKBKE2.64953887
9TAOK22.38736129
10ERN12.35169657
11TXK2.30608173
12IKBKB2.28210895
13RIPK42.21397274
14MAP3K101.96990558
15TRIB31.93571936
16STK101.92424626
17DDR21.91700821
18JAK11.88659607
19IRAK41.86581216
20FGFR41.82865009
21ZAP701.82494667
22EPHB11.81729321
23BLK1.81043351
24CHUK1.80665245
25NME21.68671649
26KIT1.66889086
27GRK71.60618855
28MAP3K131.60446519
29TTN1.57330041
30CDK121.56038997
31CDC42BPA1.54366639
32MOS1.52576232
33CSK1.49676895
34PKN21.47535186
35RPS6KA41.43071064
36PIM21.32585866
37PIM11.29085176
38PTK61.24486114
39LRRK21.21580743
40BTK1.20221498
41HCK1.19222382
42MAP2K31.17993132
43TGFBR21.17396568
44LCK1.16351983
45BMX1.14720508
46SIK31.14400935
47SYK1.14258077
48JAK21.11731649
49SMG11.10338637
50RIPK11.09705338
51MARK31.09607122
52BMPR21.09011785
53ITK1.06832823
54FGFR31.06371390
55MAP3K111.03793926
56GRK61.02296400
57MST41.01933542
58EPHA31.01276242
59ICK0.98559504
60TAOK30.97278662
61EEF2K0.96674594
62CSF1R0.96122819
63IRAK20.93708692
64ARAF0.92432361
65MAP3K30.85818062
66MATK0.82738805
67FLT30.82563560
68PDGFRA0.77739634
69TEC0.76596016
70TESK20.75611618
71KDR0.75177955
72MST1R0.74061900
73LYN0.71735944
74ALK0.69390791
75PRKG20.68720020
76NLK0.68531570
77HIPK20.67824630
78TAOK10.66023612
79PDPK10.64715287
80PAK40.64351894
81SIK20.58462184
82PDK10.58201515
83FGR0.57441258
84TRPM70.56449499
85EGFR0.55647554
86MARK20.54934998
87MAP3K80.54603204
88MAP3K10.54036698
89NEK20.53788884
90TESK10.53381433
91CDK40.52262186
92MAPK70.49993225
93ABL20.49850339
94MAP3K70.49733264
95TNK20.49443309
96STK40.49234163
97MAP3K50.49126906
98TYRO30.48813758
99ABL10.48118529
100MAPKAPK20.47852234
101FES0.47814585
102MAPK40.47391069
103CDK60.46661824
104PRKD20.46322547
105DMPK0.45027726
106RPS6KA60.44021864
107PDGFRB0.43273567
108PRKCD0.42799874
109MAPK110.42685977
110EPHA20.41584558
111RPS6KA10.39028177
112NEK90.37825005
113DAPK30.37449381
114CLK10.37438007
115MAP2K60.37293257
116MAPK120.36540479
117RPS6KA20.36072045
118MAP2K20.34516667
119LATS20.34137357
120TGFBR10.34085255
121RPS6KB20.33979760
122SIK10.32996270
123PTK20.32950074
124STK240.31281906
125MTOR0.30848839
126STK30.29182966
127RPS6KC10.28123035
128RPS6KL10.28123035
129KSR20.28115746
130DYRK1B0.27972601
131IRAK10.26781162

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.35176792
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.95788027
3Osteoclast differentiation_Homo sapiens_hsa043802.60186571
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38949922
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38620140
6Legionellosis_Homo sapiens_hsa051342.32460284
7Graft-versus-host disease_Homo sapiens_hsa053322.28478513
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24164264
9Measles_Homo sapiens_hsa051622.21702408
10TNF signaling pathway_Homo sapiens_hsa046682.13218058
11Primary immunodeficiency_Homo sapiens_hsa053402.07874168
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07237818
13Allograft rejection_Homo sapiens_hsa053302.04825449
14B cell receptor signaling pathway_Homo sapiens_hsa046621.94145074
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92305449
16Malaria_Homo sapiens_hsa051441.91854450
17Toxoplasmosis_Homo sapiens_hsa051451.88199978
18Pertussis_Homo sapiens_hsa051331.85516342
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.85432617
20Tuberculosis_Homo sapiens_hsa051521.83918697
21Antigen processing and presentation_Homo sapiens_hsa046121.83392812
22Influenza A_Homo sapiens_hsa051641.80009932
23Staphylococcus aureus infection_Homo sapiens_hsa051501.70375043
24Asthma_Homo sapiens_hsa053101.66869001
25Herpes simplex infection_Homo sapiens_hsa051681.64957109
26Apoptosis_Homo sapiens_hsa042101.63080280
27Hematopoietic cell lineage_Homo sapiens_hsa046401.54150167
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51867381
29T cell receptor signaling pathway_Homo sapiens_hsa046601.51642274
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.48748058
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48093879
32Shigellosis_Homo sapiens_hsa051311.47407471
33Salmonella infection_Homo sapiens_hsa051321.44646485
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40243588
35Rheumatoid arthritis_Homo sapiens_hsa053231.38328894
36Viral myocarditis_Homo sapiens_hsa054161.35018570
37Acute myeloid leukemia_Homo sapiens_hsa052211.32865670
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28794540
39Hepatitis B_Homo sapiens_hsa051611.27573200
40African trypanosomiasis_Homo sapiens_hsa051431.27480654
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.26412514
42Lysosome_Homo sapiens_hsa041421.20325944
43Chemokine signaling pathway_Homo sapiens_hsa040621.18864413
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18234586
45Chronic myeloid leukemia_Homo sapiens_hsa052201.17859512
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14495340
47Prion diseases_Homo sapiens_hsa050201.14304576
48Hepatitis C_Homo sapiens_hsa051601.12993661
49Bladder cancer_Homo sapiens_hsa052191.09189837
50Type I diabetes mellitus_Homo sapiens_hsa049401.08182217
51Small cell lung cancer_Homo sapiens_hsa052221.04549271
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04216470
53Amoebiasis_Homo sapiens_hsa051461.00131071
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.98723036
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97122374
56Epstein-Barr virus infection_Homo sapiens_hsa051690.96971863
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.96518106
58Prolactin signaling pathway_Homo sapiens_hsa049170.94565275
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.85822257
60Phagosome_Homo sapiens_hsa041450.85320875
61Pancreatic cancer_Homo sapiens_hsa052120.84958854
62HIF-1 signaling pathway_Homo sapiens_hsa040660.84257440
63Autoimmune thyroid disease_Homo sapiens_hsa053200.79613090
64VEGF signaling pathway_Homo sapiens_hsa043700.79386856
65Other glycan degradation_Homo sapiens_hsa005110.75816514
66Viral carcinogenesis_Homo sapiens_hsa052030.75645162
67HTLV-I infection_Homo sapiens_hsa051660.70634724
68Insulin resistance_Homo sapiens_hsa049310.70374094
69Platelet activation_Homo sapiens_hsa046110.67298299
70Notch signaling pathway_Homo sapiens_hsa043300.66060700
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62970894
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61059427
73mTOR signaling pathway_Homo sapiens_hsa041500.60854691
74Proteoglycans in cancer_Homo sapiens_hsa052050.59899994
75Complement and coagulation cascades_Homo sapiens_hsa046100.58738531
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58336756
77Type II diabetes mellitus_Homo sapiens_hsa049300.58205505
78p53 signaling pathway_Homo sapiens_hsa041150.56803710
79Caffeine metabolism_Homo sapiens_hsa002320.56095754
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52596208
81MicroRNAs in cancer_Homo sapiens_hsa052060.51161500
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50227812
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45596520
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.42852619
85Adherens junction_Homo sapiens_hsa045200.41643016
86FoxO signaling pathway_Homo sapiens_hsa040680.40507267
87Focal adhesion_Homo sapiens_hsa045100.40464035
88Systemic lupus erythematosus_Homo sapiens_hsa053220.39521913
89Endocytosis_Homo sapiens_hsa041440.38145976
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37772045
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37310054
92GnRH signaling pathway_Homo sapiens_hsa049120.35483485
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.34743869
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.34285773
95Renal cell carcinoma_Homo sapiens_hsa052110.34037665
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33069606
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31560278
98Insulin signaling pathway_Homo sapiens_hsa049100.31117962
99PPAR signaling pathway_Homo sapiens_hsa033200.31058644
100Dorso-ventral axis formation_Homo sapiens_hsa043200.30675632
101Colorectal cancer_Homo sapiens_hsa052100.29810841
102Sphingolipid metabolism_Homo sapiens_hsa006000.29426003
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29414299
104Pentose phosphate pathway_Homo sapiens_hsa000300.28297791
105Non-small cell lung cancer_Homo sapiens_hsa052230.27688391
106Mineral absorption_Homo sapiens_hsa049780.27572828
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27471234
108MAPK signaling pathway_Homo sapiens_hsa040100.27326313
109Galactose metabolism_Homo sapiens_hsa000520.27092935
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26728118
111Prostate cancer_Homo sapiens_hsa052150.26119550
112Pathways in cancer_Homo sapiens_hsa052000.24913746
113Fructose and mannose metabolism_Homo sapiens_hsa000510.24882728
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24342480

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