TNIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)8.22114772
2DNA strand elongation involved in DNA replication (GO:0006271)7.37488377
3DNA strand elongation (GO:0022616)7.08773642
4regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)7.05157124
5ribosomal small subunit biogenesis (GO:0042274)7.02093699
6ribosomal small subunit assembly (GO:0000028)6.79766579
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.63286905
8regulation of DNA damage checkpoint (GO:2000001)6.20336930
9spliceosomal tri-snRNP complex assembly (GO:0000244)5.52497564
10G1 DNA damage checkpoint (GO:0044783)5.34110073
11nuclear pore complex assembly (GO:0051292)5.17921928
12mitotic G1 DNA damage checkpoint (GO:0031571)5.13530724
13regulation of mitotic spindle organization (GO:0060236)5.08359426
14ribosomal large subunit biogenesis (GO:0042273)5.06454234
15neutrophil activation involved in immune response (GO:0002283)4.95399916
16mitotic chromosome condensation (GO:0007076)4.92003590
17positive regulation of gamma-delta T cell activation (GO:0046645)4.86660991
18positive regulation of natural killer cell differentiation (GO:0032825)4.83636955
19mitotic G1/S transition checkpoint (GO:0044819)4.82254369
20viral transcription (GO:0019083)4.80737588
21antigen processing and presentation of endogenous antigen (GO:0019883)4.80567166
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62135092
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62135092
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58711386
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.58711386
26modulation by symbiont of host immune response (GO:0052553)4.58711386
27positive regulation by symbiont of host defense response (GO:0052509)4.58711386
28modulation by symbiont of host defense response (GO:0052031)4.58711386
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58711386
30DNA replication checkpoint (GO:0000076)4.53032742
31translational termination (GO:0006415)4.51070779
32DNA topological change (GO:0006265)4.40551384
33nuclear pore organization (GO:0006999)4.37110146
34NIK/NF-kappaB signaling (GO:0038061)4.31287157
35embryonic skeletal joint morphogenesis (GO:0060272)4.31283581
36macrophage activation involved in immune response (GO:0002281)4.26647074
37regulation of spindle organization (GO:0090224)4.26442615
38cellular response to exogenous dsRNA (GO:0071360)4.25005645
39translesion synthesis (GO:0019985)4.24253203
40telomere maintenance via semi-conservative replication (GO:0032201)4.21534296
41antigen processing and presentation via MHC class Ib (GO:0002475)4.21431914
42immunoglobulin mediated immune response (GO:0016064)4.21402953
43positive regulation of antigen processing and presentation (GO:0002579)4.17816098
44pore complex assembly (GO:0046931)4.09978295
45regulation of interferon-beta biosynthetic process (GO:0045357)4.07022654
46rRNA transcription (GO:0009303)4.03708644
47regulation of cell cycle checkpoint (GO:1901976)4.02103563
48DNA duplex unwinding (GO:0032508)4.00910640
49protein localization to chromosome, centromeric region (GO:0071459)3.99787639
50response to type I interferon (GO:0034340)3.96722214
51microtubule polymerization or depolymerization (GO:0031109)3.95163469
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.93847941
53type I interferon signaling pathway (GO:0060337)3.92735428
54cellular response to type I interferon (GO:0071357)3.92735428
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.91571338
56positive regulation of T cell apoptotic process (GO:0070234)3.89612818
57interferon-gamma-mediated signaling pathway (GO:0060333)3.82819574
58negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.82713594
59negative regulation of meiosis (GO:0045835)3.82679353
60regulation of interleukin-12 biosynthetic process (GO:0045075)3.80940211
61viral life cycle (GO:0019058)3.80626261
62myeloid dendritic cell differentiation (GO:0043011)3.79942568
63DNA geometric change (GO:0032392)3.78720723
64negative regulation of DNA-templated transcription, elongation (GO:0032785)3.74834314
65formation of translation preinitiation complex (GO:0001731)3.70011969
66myeloid dendritic cell activation (GO:0001773)3.69730112
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.68647907
68mitotic metaphase plate congression (GO:0007080)3.68577106
69response to muramyl dipeptide (GO:0032495)3.68462492
70neutrophil activation (GO:0042119)3.67130650
71defense response to protozoan (GO:0042832)3.66555845
72telomere maintenance via recombination (GO:0000722)3.64503367
73cellular protein complex disassembly (GO:0043624)3.64183438
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.63847908
75myeloid cell homeostasis (GO:0002262)3.63167828
76granulocyte activation (GO:0036230)3.62943681
77response to interferon-beta (GO:0035456)3.60471185
78regulation of antigen processing and presentation (GO:0002577)3.56778413
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56610375
80positive regulation of interferon-alpha production (GO:0032727)3.56424718
81translational elongation (GO:0006414)3.52069981
82response to interferon-alpha (GO:0035455)3.50348247
83oocyte maturation (GO:0001556)3.50206339
84response to peptidoglycan (GO:0032494)3.48958816
85ventricular cardiac muscle cell development (GO:0055015)3.47573854
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46881120
87translational initiation (GO:0006413)3.45979094
88regulation of B cell receptor signaling pathway (GO:0050855)3.43876840
89myeloid cell activation involved in immune response (GO:0002275)3.42082139
90cellular response to interferon-beta (GO:0035458)3.41577359
91regulation of gamma-delta T cell activation (GO:0046643)3.40186211
92ribonucleoprotein complex biogenesis (GO:0022613)3.39646249
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37613371
94response to protozoan (GO:0001562)3.37217503
95regulation of natural killer cell differentiation (GO:0032823)3.37063020
96negative regulation of histone methylation (GO:0031061)3.35586155
97positive regulation of lymphocyte apoptotic process (GO:0070230)3.35547519
98regulation of interferon-alpha production (GO:0032647)3.35526940
99cell cycle G1/S phase transition (GO:0044843)3.34141159
100G1/S transition of mitotic cell cycle (GO:0000082)3.34141159
101dendritic cell differentiation (GO:0097028)3.32663533
102T-helper 1 type immune response (GO:0042088)3.31803239
103negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.31500094
104positive regulation of B cell differentiation (GO:0045579)3.30705511
105mitotic cytokinesis (GO:0000281)3.30499783
106protein targeting to ER (GO:0045047)3.30445207
107positive regulation of natural killer cell activation (GO:0032816)3.29015685
108histone H2B ubiquitination (GO:0033523)3.27002468
109cotranslational protein targeting to membrane (GO:0006613)3.26889989
110histone H3-K9 demethylation (GO:0033169)3.26001327
111protein complex disassembly (GO:0043241)3.24336097
112regulation of gamma-delta T cell differentiation (GO:0045586)3.22923696
113mature B cell differentiation (GO:0002335)3.21136441
114establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19382679
115B cell mediated immunity (GO:0019724)3.19369221
116mature B cell differentiation involved in immune response (GO:0002313)3.18891365
117post-embryonic morphogenesis (GO:0009886)3.18034238
118DNA conformation change (GO:0071103)3.15997279
119respiratory burst (GO:0045730)3.15193852
120positive regulation of interleukin-17 production (GO:0032740)3.14844361
121positive regulation of interferon-beta production (GO:0032728)3.14283672
122regulation of RIG-I signaling pathway (GO:0039535)3.14249359
123cellular response to interleukin-4 (GO:0071353)3.13175748
124lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08218646
125macromolecular complex disassembly (GO:0032984)3.07486675
126protein localization to endoplasmic reticulum (GO:0070972)3.03761227
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03522884
128regulation of T-helper 1 cell differentiation (GO:0045625)3.02303494
129microglial cell activation (GO:0001774)3.01611199
130macrophage activation (GO:0042116)3.01008032
131regulation of B cell differentiation (GO:0045577)2.98636187
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97159095
133T cell migration (GO:0072678)2.97123040
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95253339
135response to host immune response (GO:0052572)2.95253339
136positive regulation of interleukin-12 production (GO:0032735)2.95069833
137mitotic recombination (GO:0006312)2.93711356
138negative regulation of interleukin-12 production (GO:0032695)2.93584232
139T cell apoptotic process (GO:0070231)2.92987835
140negative regulation of mRNA processing (GO:0050686)2.91628632
141response to host (GO:0075136)2.91088267
142response to host defenses (GO:0052200)2.91088267
143response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91088267
144natural killer cell differentiation (GO:0001779)2.88599997
145myeloid leukocyte activation (GO:0002274)2.87916291
146ectodermal placode formation (GO:0060788)2.86882535
147production of molecular mediator involved in inflammatory response (GO:0002532)2.86529789
148cellular protein complex localization (GO:0034629)2.84328434
149regulation of natural killer cell activation (GO:0032814)2.83977974
150mitotic sister chromatid cohesion (GO:0007064)2.83777933
151natural killer cell mediated immunity (GO:0002228)2.82737507
152natural killer cell mediated cytotoxicity (GO:0042267)2.82737507
153histone phosphorylation (GO:0016572)2.82653102
154DNA replication (GO:0006260)2.82184731
155regulation of mast cell degranulation (GO:0043304)2.81572444
156positive regulation of chemokine biosynthetic process (GO:0045080)2.80558375
157SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.80301733
158cellular response to interferon-gamma (GO:0071346)2.79851991
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78367595
160dendritic cell chemotaxis (GO:0002407)2.78127843
161negative regulation of viral genome replication (GO:0045071)2.75514585
162response to interleukin-4 (GO:0070670)2.73547998
163negative regulation of erythrocyte differentiation (GO:0045647)2.73121310
164pinocytosis (GO:0006907)2.72894840
165regulation of alpha-beta T cell proliferation (GO:0046640)2.72674956
166regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72298861
167regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.71977951
168dosage compensation (GO:0007549)2.71636567
169response to interferon-gamma (GO:0034341)2.71537611
170RNA localization (GO:0006403)2.71169949
171regulation of interleukin-17 production (GO:0032660)2.70338681
172germinal center formation (GO:0002467)2.69944990
173regulation of interleukin-12 production (GO:0032655)2.69917292
174regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.69124882
175rRNA processing (GO:0006364)2.68731777
176negative regulation of RNA splicing (GO:0033119)2.68155728
177ribosome assembly (GO:0042255)2.67604845
178metaphase plate congression (GO:0051310)2.66633953
179cellular response to zinc ion (GO:0071294)2.66545791
180regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65523674
181response to interleukin-15 (GO:0070672)2.63395366
182regulation of MHC class II biosynthetic process (GO:0045346)2.63153936
183regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60531803
184adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.59480416
185dendritic cell migration (GO:0036336)2.59434783
186negative regulation of mRNA metabolic process (GO:1903312)2.58819267
187telomere maintenance via telomere lengthening (GO:0010833)2.57499609
188nuclear-transcribed mRNA catabolic process (GO:0000956)2.56779648
189histone demethylation (GO:0016577)2.54638585
190rRNA catabolic process (GO:0016075)2.53561957
191mismatch repair (GO:0006298)2.51478038
192rRNA metabolic process (GO:0016072)2.50815104
193mRNA catabolic process (GO:0006402)2.50208619
194lymphocyte apoptotic process (GO:0070227)2.46984280
195DNA synthesis involved in DNA repair (GO:0000731)2.46390598
196negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.45847528
197negative regulation of chromosome segregation (GO:0051985)2.43739201
198maturation of SSU-rRNA (GO:0030490)14.5760824
199DNA unwinding involved in DNA replication (GO:0006268)12.1451042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.97186921
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.88871567
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.88700156
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.37043582
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25722209
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.14408166
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.11382456
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.66555523
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.58437521
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57704653
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53058780
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34951422
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29055971
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98222127
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.90818503
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.83887021
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77649260
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73892961
19SCL_19346495_ChIP-Seq_HPC-7_Human2.72592304
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.67438525
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65323420
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64509577
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60505234
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52521827
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48768156
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42944081
27XRN2_22483619_ChIP-Seq_HELA_Human2.41569372
28AR_21909140_ChIP-Seq_LNCAP_Human2.33519642
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30157264
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28032775
31SPI1_23547873_ChIP-Seq_NB4_Human2.23266822
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22971026
33* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22182564
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20238348
35RUNX_20019798_ChIP-Seq_JUKART_Human2.18028175
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10436331
37GATA1_22025678_ChIP-Seq_K562_Human2.05423376
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04986330
39E2F1_21310950_ChIP-Seq_MCF-7_Human2.03220033
40BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02895040
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02079329
42MYB_26560356_Chip-Seq_TH2_Human2.01086962
43E2F7_22180533_ChIP-Seq_HELA_Human10.9986944
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97945587
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96994534
46VDR_21846776_ChIP-Seq_THP-1_Human1.96225962
47VDR_24763502_ChIP-Seq_THP-1_Human1.92215302
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90460919
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90437523
50DCP1A_22483619_ChIP-Seq_HELA_Human1.83066914
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82927295
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.82532658
53MAF_26560356_Chip-Seq_TH1_Human1.82193630
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82046155
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80309549
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79168996
57ZNF263_19887448_ChIP-Seq_K562_Human1.78795275
58TTF2_22483619_ChIP-Seq_HELA_Human1.77630367
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.76051715
60* TCF7_22412390_ChIP-Seq_EML_Mouse1.70894657
61PU_27001747_Chip-Seq_BMDM_Mouse1.70857535
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66791181
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66745480
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.66695187
65SPI1_23127762_ChIP-Seq_K562_Human1.66237467
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.65320132
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64000984
68MYB_26560356_Chip-Seq_TH1_Human1.62855720
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61154405
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60669877
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.60069642
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59905983
73KDM5A_27292631_Chip-Seq_BREAST_Human1.59270183
74GABP_19822575_ChIP-Seq_HepG2_Human1.58151065
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56722839
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56376196
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55489105
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.55418426
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51630944
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.51538932
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50445323
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44844200
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.44723149
84* MYC_22102868_ChIP-Seq_BL_Human1.44432696
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42497821
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39466450
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.38885292
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35995693
89UTX_26944678_Chip-Seq_JUKART_Human1.34480946
90* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33823453
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33572887
92CIITA_25753668_ChIP-Seq_RAJI_Human1.31909223
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31830829
94* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31734184
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.29933541
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29584781
97* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29378344
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27027568
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25770282
100GATA3_27048872_Chip-Seq_THYMUS_Human1.23996340
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23856297
102* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23357798
103VDR_24787735_ChIP-Seq_THP-1_Human1.22496824
104FOXP3_21729870_ChIP-Seq_TREG_Human1.22417708
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22335690
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22278992
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20501917
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20319895
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19569270
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18132986
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17942235
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17623035
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15756801
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14786292
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13270516
116* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13227932
117* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12754741
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12394011
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12099282
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09439188
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09148293
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07665189
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07067657
124MAF_26560356_Chip-Seq_TH2_Human1.06245760
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04714609
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.03778279
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03667221
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02512530
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01418823
130SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00630222
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00601677
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99413702
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98252081
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.98152909
135EST1_17652178_ChIP-ChIP_JURKAT_Human0.97865262
136GATA3_26560356_Chip-Seq_TH2_Human0.97314630
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96940130
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96446702
139KDM2B_26808549_Chip-Seq_DND41_Human0.94206620
140RACK7_27058665_Chip-Seq_MCF-7_Human0.93568447
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93377471
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92680157
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92087147
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91303833
145* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90924969
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88982648
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88640378
148* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87670151
149* VDR_23849224_ChIP-Seq_CD4+_Human0.87611784
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.85773462
151ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84735633
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84701415
153TRIM28_21343339_ChIP-Seq_HEK293_Human0.83809016
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82988712
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82665673
156ATF3_27146783_Chip-Seq_COLON_Human0.81142705
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80667884
158TP53_22127205_ChIP-Seq_IMR90_Human0.80045468
159FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78685201
160* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78380600
161* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76208213
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76052632
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76052632
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74348319
165NCOR1_26117541_ChIP-Seq_K562_Human0.74127219
166TFEB_21752829_ChIP-Seq_HELA_Human0.73246235
167LXR_22292898_ChIP-Seq_THP-1_Human0.72824114
168* BCL6_27268052_Chip-Seq_Bcells_Human0.70587111
169GATA1_19941826_ChIP-Seq_K562_Human0.70142190
170RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70080167
171SOX2_20726797_ChIP-Seq_SW620_Human0.68088146
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66560988
173GATA2_19941826_ChIP-Seq_K562_Human0.64025056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps6.41357118
2MP0001835_abnormal_antigen_presentation4.85930321
3MP0010094_abnormal_chromosome_stability4.83813468
4MP0003693_abnormal_embryo_hatching4.66216598
5MP0003111_abnormal_nucleus_morphology4.56070311
6MP0003123_paternal_imprinting4.12209018
7MP0003077_abnormal_cell_cycle3.80614853
8MP0003436_decreased_susceptibility_to3.47731220
9MP0000685_abnormal_immune_system3.29760104
10MP0008057_abnormal_DNA_replication3.24404529
11MP0009785_altered_susceptibility_to3.21918502
12MP0002148_abnormal_hypersensitivity_rea3.09266163
13MP0001790_abnormal_immune_system3.02588339
14MP0005387_immune_system_phenotype3.02588339
15MP0003724_increased_susceptibility_to3.01761600
16MP0004957_abnormal_blastocyst_morpholog2.99868080
17MP0005000_abnormal_immune_tolerance2.90891445
18MP0004510_myositis2.84688459
19MP0000747_muscle_weakness2.82759154
20MP0005025_abnormal_response_to2.75084649
21* MP0002419_abnormal_innate_immunity2.74711407
22MP0008995_early_reproductive_senescence2.72250273
23MP0001800_abnormal_humoral_immune2.66409560
24MP0005671_abnormal_response_to2.62814973
25* MP0002452_abnormal_antigen_presenting2.58441861
26MP0002723_abnormal_immune_serum2.53895207
27MP0008058_abnormal_DNA_repair2.47866437
28MP0009278_abnormal_bone_marrow2.47108477
29MP0003303_peritoneal_inflammation2.44106245
30MP0002254_reproductive_system_inflammat2.40356460
31MP0010234_abnormal_vibrissa_follicle2.30642095
32* MP0001819_abnormal_immune_cell2.29442579
33* MP0002420_abnormal_adaptive_immunity2.26940833
34MP0006082_CNS_inflammation2.24916883
35MP0008007_abnormal_cellular_replicative2.19771456
36MP0000537_abnormal_urethra_morphology2.14383807
37MP0001853_heart_inflammation2.10675907
38MP0002166_altered_tumor_susceptibility2.10383555
39MP0005397_hematopoietic_system_phenotyp2.07647472
40MP0001545_abnormal_hematopoietic_system2.07647472
41MP0008932_abnormal_embryonic_tissue2.05571158
42MP0005076_abnormal_cell_differentiation2.00641248
43MP0002006_tumorigenesis1.92122500
44MP0005464_abnormal_platelet_physiology1.91211949
45MP0001873_stomach_inflammation1.88137608
46MP0005310_abnormal_salivary_gland1.85564103
47MP0001533_abnormal_skeleton_physiology1.82418314
48MP0003172_abnormal_lysosome_physiology1.78722211
49MP0001845_abnormal_inflammatory_respons1.77929720
50MP0002398_abnormal_bone_marrow1.76132195
51MP0003786_premature_aging1.75961049
52MP0010155_abnormal_intestine_physiology1.75754528
53MP0000716_abnormal_immune_system1.75239358
54MP0002405_respiratory_system_inflammati1.74436173
55MP0005058_abnormal_lysosome_morphology1.74354445
56MP0000350_abnormal_cell_proliferation1.73690073
57MP0004233_abnormal_muscle_weight1.73158530
58MP0009333_abnormal_splenocyte_physiolog1.72202444
59MP0009764_decreased_sensitivity_to1.64853770
60MP0003121_genomic_imprinting1.59968540
61MP0001727_abnormal_embryo_implantation1.55332566
62MP0001730_embryonic_growth_arrest1.55192453
63MP0003763_abnormal_thymus_physiology1.54587673
64MP0003300_gastrointestinal_ulcer1.54556134
65MP0004947_skin_inflammation1.54072971
66MP0009672_abnormal_birth_weight1.53419925
67MP0008469_abnormal_protein_level1.51074992
68MP0000689_abnormal_spleen_morphology1.47758629
69MP0005174_abnormal_tail_pigmentation1.46057717
70MP0003191_abnormal_cellular_cholesterol1.45906522
71MP0003828_pulmonary_edema1.45615485
72MP0003448_altered_tumor_morphology1.45392224
73MP0002429_abnormal_blood_cell1.42587368
74MP0002877_abnormal_melanocyte_morpholog1.41845960
75MP0003787_abnormal_imprinting1.41840568
76MP0005623_abnormal_meninges_morphology1.39441223
77MP0002722_abnormal_immune_system1.39372853
78MP0002933_joint_inflammation1.37048219
79MP0002396_abnormal_hematopoietic_system1.34171922
80MP0002084_abnormal_developmental_patter1.27360622
81MP0002138_abnormal_hepatobiliary_system1.27040577
82MP0004808_abnormal_hematopoietic_stem1.26811394
83MP0001849_ear_inflammation1.26618922
84MP0000313_abnormal_cell_death1.26586512
85MP0000465_gastrointestinal_hemorrhage1.21874930
86MP0000858_altered_metastatic_potential1.21065262
87MP0001697_abnormal_embryo_size1.20949762
88MP0002249_abnormal_larynx_morphology1.20709293
89MP0003866_abnormal_defecation1.20514330
90MP0002080_prenatal_lethality1.20109651
91MP0002998_abnormal_bone_remodeling1.17185735
92MP0002085_abnormal_embryonic_tissue1.16828344
93MP0005451_abnormal_body_composition1.14112435
94MP0001672_abnormal_embryogenesis/_devel1.13144688
95MP0005380_embryogenesis_phenotype1.13144688
96MP0000003_abnormal_adipose_tissue1.09285490
97MP0002086_abnormal_extraembryonic_tissu1.08698293
98MP0003705_abnormal_hypodermis_morpholog1.06406343
99MP0005166_decreased_susceptibility_to1.04127163
100MP0003075_altered_response_to1.03316890
101MP0000343_altered_response_to1.02493239
102MP0000371_diluted_coat_color1.01786246
103MP0001346_abnormal_lacrimal_gland1.01781912
104MP0009840_abnormal_foam_cell1.00883685
105MP0003566_abnormal_cell_adhesion0.97283192
106MP0003984_embryonic_growth_retardation0.96703464
107MP0001851_eye_inflammation0.96086080
108MP0005390_skeleton_phenotype0.95272200
109MP0002075_abnormal_coat/hair_pigmentati0.93513796
110MP0002088_abnormal_embryonic_growth/wei0.93484947
111MP0003091_abnormal_cell_migration0.91592280
112MP0000703_abnormal_thymus_morphology0.90399255
113MP0003453_abnormal_keratinocyte_physiol0.89407543
114MP0004858_abnormal_nervous_system0.88582795
115MP0000477_abnormal_intestine_morphology0.88039720
116MP0000767_abnormal_smooth_muscle0.87621144
117MP0003942_abnormal_urinary_system0.86769484
118MP0000015_abnormal_ear_pigmentation0.85138181
119MP0000516_abnormal_urinary_system0.85001794
120MP0005367_renal/urinary_system_phenotyp0.85001794
121MP0001879_abnormal_lymphatic_vessel0.80798726
122MP0009763_increased_sensitivity_to0.78701577
123MP0005075_abnormal_melanosome_morpholog0.76318408
124MP0002269_muscular_atrophy0.75837041
125MP0001348_abnormal_lacrimal_gland0.75608851
126MP0008260_abnormal_autophagy0.75495943
127MP0005023_abnormal_wound_healing0.74769948
128MP0010307_abnormal_tumor_latency0.73499949
129MP0009703_decreased_birth_body0.73018615
130MP0003122_maternal_imprinting0.72981849
131MP0003183_abnormal_peptide_metabolism0.72591932
132MP0004782_abnormal_surfactant_physiolog0.71693452
133MP0000428_abnormal_craniofacial_morphol0.71256235
134MP0002697_abnormal_eye_size0.70765649
135MP0001186_pigmentation_phenotype0.70448529
136MP0005621_abnormal_cell_physiology0.70308686
137MP0005384_cellular_phenotype0.70231885
138MP0005164_abnormal_response_to0.69994255
139MP0003806_abnormal_nucleotide_metabolis0.69471270
140MP0002092_abnormal_eye_morphology0.67657856
141MP0002177_abnormal_outer_ear0.66763953
142MP0002160_abnormal_reproductive_system0.66078690
143MP0010368_abnormal_lymphatic_system0.65486717
144MP0000249_abnormal_blood_vessel0.64985724
145MP0003795_abnormal_bone_structure0.64972340
146MP0003045_fibrosis0.63358868
147MP0000383_abnormal_hair_follicle0.63083697
148MP0002277_abnormal_respiratory_mucosa0.62670305
149MP0005501_abnormal_skin_physiology0.62251155
150MP0005375_adipose_tissue_phenotype0.61978434
151MP0002693_abnormal_pancreas_physiology0.61274198
152MP0002098_abnormal_vibrissa_morphology0.61171520
153MP0001881_abnormal_mammary_gland0.60313870
154MP0002060_abnormal_skin_morphology0.59891605
155MP0002163_abnormal_gland_morphology0.58777764
156MP0000750_abnormal_muscle_regeneration0.57931921
157MP0001663_abnormal_digestive_system0.57765524
158MP0000604_amyloidosis0.57490613
159MP0001191_abnormal_skin_condition0.57322959
160MP0002932_abnormal_joint_morphology0.57298044
161MP0000733_abnormal_muscle_development0.56203572
162MP0002019_abnormal_tumor_incidence0.54145731
163MP0002136_abnormal_kidney_physiology0.53899511
164MP0001216_abnormal_epidermal_layer0.53670813
165MP0003221_abnormal_cardiomyocyte_apopto0.53594465
166MP0000358_abnormal_cell_content/0.52547738
167MP0002095_abnormal_skin_pigmentation0.51672648
168MP0000490_abnormal_crypts_of0.50155133
169MP0004185_abnormal_adipocyte_glucose0.49920521
170MP0000569_abnormal_digit_pigmentation0.47843174

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.83497061
2Septate vagina (HP:0001153)5.83627609
3Eczematoid dermatitis (HP:0000976)5.64196913
4Recurrent abscess formation (HP:0002722)5.38543877
5Recurrent bacterial skin infections (HP:0005406)5.19745458
6Birth length less than 3rd percentile (HP:0003561)4.73557703
7Recurrent fungal infections (HP:0002841)4.65586782
8Chronic mucocutaneous candidiasis (HP:0002728)4.57634775
9Recurrent cutaneous fungal infections (HP:0011370)4.57634775
10Elevated erythrocyte sedimentation rate (HP:0003565)4.43438136
11Myositis (HP:0100614)4.35016568
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.33818689
13Aplasia/Hypoplasia of the sacrum (HP:0008517)4.22806194
14Abnormal hemoglobin (HP:0011902)4.19857939
15Recurrent skin infections (HP:0001581)4.14406682
16Recurrent viral infections (HP:0004429)4.13115055
17Vacuolated lymphocytes (HP:0001922)4.12960528
18Colitis (HP:0002583)4.10747753
19Recurrent gram-negative bacterial infections (HP:0005420)4.09785044
20Abnormality of the anterior horn cell (HP:0006802)4.06937646
21Degeneration of anterior horn cells (HP:0002398)4.06937646
22Abnormality of macrophages (HP:0004311)3.95294666
23Abnormal number of incisors (HP:0011064)3.89381993
24Hyperthyroidism (HP:0000836)3.83053532
25Panhypogammaglobulinemia (HP:0003139)3.79607724
26Inflammation of the large intestine (HP:0002037)3.64294077
27Squamous cell carcinoma (HP:0002860)3.58615858
28Thrombocytosis (HP:0001894)3.56264102
29Interstitial pulmonary disease (HP:0006530)3.55094987
30Diastasis recti (HP:0001540)3.47818880
31Pustule (HP:0200039)3.47032437
32Orchitis (HP:0100796)3.44558681
33Aplastic anemia (HP:0001915)3.44112446
34Chronic otitis media (HP:0000389)3.41138052
35Gastrointestinal inflammation (HP:0004386)3.40759669
36Mediastinal lymphadenopathy (HP:0100721)3.39217414
37Agammaglobulinemia (HP:0004432)3.38220521
38Apathy (HP:0000741)3.33421528
39Optic neuritis (HP:0100653)3.24246667
40Retrobulbar optic neuritis (HP:0100654)3.24246667
41Gingivitis (HP:0000230)3.22084284
42Ulnar bowing (HP:0003031)3.17673469
43Abnormality of T cell physiology (HP:0011840)3.07794169
44Vasculitis (HP:0002633)3.07709370
45Cutaneous melanoma (HP:0012056)3.06942132
46Cellulitis (HP:0100658)3.06808072
47Truncus arteriosus (HP:0001660)3.00849989
48Diminished motivation (HP:0000745)2.95220439
49Increased cerebral lipofuscin (HP:0011813)2.93910827
50Increased IgE level (HP:0003212)2.93095802
51Macrocytic anemia (HP:0001972)2.92400781
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.89852448
53Meningitis (HP:0001287)2.81848826
54Periodontitis (HP:0000704)2.75478683
55Hyperacusis (HP:0010780)2.75185329
56IgM deficiency (HP:0002850)2.74975026
57Pulmonary infiltrates (HP:0002113)2.71392420
58Hypergammaglobulinemia (HP:0010702)2.71254671
59Gingival bleeding (HP:0000225)2.71028210
60Petechiae (HP:0000967)2.70149887
61Facial cleft (HP:0002006)2.70091560
62Persistence of primary teeth (HP:0006335)2.69703394
63Increased IgM level (HP:0003496)2.67767910
64Recurrent bronchitis (HP:0002837)2.67687061
65Vaginal fistula (HP:0004320)2.66721861
66Large hands (HP:0001176)2.66576379
67Axonal loss (HP:0003447)2.62911565
68Myocardial infarction (HP:0001658)2.62196002
69Loss of speech (HP:0002371)2.61490146
70Autoimmune thrombocytopenia (HP:0001973)2.55161290
71Germ cell neoplasia (HP:0100728)2.54026137
72Recurrent lower respiratory tract infections (HP:0002783)2.53602527
73Enlarged penis (HP:0000040)2.52410819
74Systemic lupus erythematosus (HP:0002725)2.51806099
75Rectal fistula (HP:0100590)2.50954700
76Rectovaginal fistula (HP:0000143)2.50954700
77Arterial thrombosis (HP:0004420)2.49782713
78Selective tooth agenesis (HP:0001592)2.48611625
79Gastrointestinal stroma tumor (HP:0100723)2.47180248
80Mutism (HP:0002300)2.47097771
81Restlessness (HP:0000711)2.47053390
82Conjunctival telangiectasia (HP:0000524)2.46330701
83Stomatitis (HP:0010280)2.45388267
84Slender long bone (HP:0003100)2.43277893
85Basal ganglia calcification (HP:0002135)2.42832776
86Abnormality of the fingertips (HP:0001211)2.41798033
87Type 2 muscle fiber atrophy (HP:0003554)2.41457919
88Neonatal hypoglycemia (HP:0001998)2.40450517
89Distal lower limb amyotrophy (HP:0008944)2.40377984
90Hematochezia (HP:0002573)2.39454009
91Dysostosis multiplex (HP:0000943)2.38181782
92Abnormality of the nasal mucosa (HP:0000433)2.37317925
93Muscle fiber atrophy (HP:0100295)2.37011777
94Pallor (HP:0000980)2.35662607
95Disinhibition (HP:0000734)2.35102324
96Keratoconjunctivitis (HP:0001096)2.34589915
97Obstructive lung disease (HP:0006536)2.34217399
98Chronic obstructive pulmonary disease (HP:0006510)2.34217399
99Broad distal phalanx of finger (HP:0009836)2.28141176
100Subacute progressive viral hepatitis (HP:0006572)2.28045530
101Abnormality of T cells (HP:0002843)2.27566709
102Leukocytosis (HP:0001974)2.26997292
103Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26703534
104Recurrent pneumonia (HP:0006532)2.26223728
105Emphysema (HP:0002097)2.26095883
106Prolonged bleeding time (HP:0003010)2.25277517
107Epistaxis (HP:0000421)2.24496643
108Overlapping toe (HP:0001845)2.23811937
109Osteomyelitis (HP:0002754)2.23326119
110Conjunctival hamartoma (HP:0100780)2.22661772
111Hemoptysis (HP:0002105)2.20769274
112Intestinal fistula (HP:0100819)2.20235524
113Keratoconjunctivitis sicca (HP:0001097)2.19670628
114Deep palmar crease (HP:0006191)2.18042800
115Encephalitis (HP:0002383)2.16971679
116Impaired platelet aggregation (HP:0003540)2.16498538
117Abnormal platelet function (HP:0011869)2.16498538
118Urticaria (HP:0001025)2.16074573
119Microvesicular hepatic steatosis (HP:0001414)2.14749954
120Sandal gap (HP:0001852)2.13824897
121Chronic diarrhea (HP:0002028)2.13502469
122Personality changes (HP:0000751)2.13303188
123Vertebral compression fractures (HP:0002953)2.11998670
124Mucosal telangiectasiae (HP:0100579)2.10502550
125Patellar dislocation (HP:0002999)2.09705986
126Nasal polyposis (HP:0100582)2.08419705
127Restrictive lung disease (HP:0002091)2.08246215
128Abnormal umbilical cord blood vessels (HP:0011403)2.06426637
129Single umbilical artery (HP:0001195)2.06426637
130Abnormality of the fetal cardiovascular system (HP:0010948)2.06426637
131Abnormality of lateral ventricle (HP:0030047)2.06370922
132Limb hypertonia (HP:0002509)2.06160660
133Aplasia cutis congenita (HP:0001057)2.05970702
134Neoplasm of head and neck (HP:0012288)2.04651986
135Esophageal neoplasm (HP:0100751)2.04651986
136Mucopolysacchariduria (HP:0008155)2.04535379
137Urinary glycosaminoglycan excretion (HP:0003541)2.04535379
138Entropion (HP:0000621)2.03151221
139Abnormality of liposaccharide metabolism (HP:0010968)2.03039605
140Abnormality of glycosphingolipid metabolism (HP:0004343)2.03039605
141Abnormality of glycolipid metabolism (HP:0010969)2.03039605
142Tetraparesis (HP:0002273)2.02838711
143Seborrheic dermatitis (HP:0001051)2.01021525
144High anterior hairline (HP:0009890)2.00537059
145Breast hypoplasia (HP:0003187)2.00060778
146Abnormality of the distal phalanges of the toes (HP:0010182)1.99670656
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98338614
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98338614
149Abnormality of polysaccharide metabolism (HP:0011012)1.98338614
150Premature loss of primary teeth (HP:0006323)1.96747354
151Hamartoma of the eye (HP:0010568)1.96322196
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.95789279
153Osteolytic defects of the hand bones (HP:0009699)1.95789279
154Cheilitis (HP:0100825)1.95780169
155Hyperphosphatemia (HP:0002905)1.95383668
156Abnormality of dentin (HP:0010299)1.95162783
157IgA deficiency (HP:0002720)1.94351886
158Thin ribs (HP:0000883)1.94173354
159Poor head control (HP:0002421)1.94071944
160Spondylolisthesis (HP:0003302)1.92778457
161Progressive visual loss (HP:0000529)1.92558207
162Lymphopenia (HP:0001888)1.92323595
163Long clavicles (HP:0000890)1.92256415
164Skin ulcer (HP:0200042)1.92243813
165Deep philtrum (HP:0002002)1.90594634
166Hypoparathyroidism (HP:0000829)1.90060262
167Cafe-au-lait spot (HP:0000957)1.90001734
168Macroorchidism (HP:0000053)1.88425463
169Eosinophilia (HP:0001880)1.87838725
170Fasciculations (HP:0002380)1.87199975
171Chronic sinusitis (HP:0011109)1.86761281
172Abnormal large intestine physiology (HP:0012700)1.86749774
173Abnormality of cells of the erythroid lineage (HP:0012130)1.86462378
174Spontaneous hematomas (HP:0007420)1.86412585
175Abnormality of cells of the lymphoid lineage (HP:0012140)1.86147599
176Abnormality of reticulocytes (HP:0004312)1.86047306
177Horseshoe kidney (HP:0000085)1.84945031
178Azoospermia (HP:0000027)1.84309370
179Bowel incontinence (HP:0002607)1.83786704
180Micronodular cirrhosis (HP:0001413)1.83163660
181Pelvic girdle muscle weakness (HP:0003749)1.82778532
182Tongue fasciculations (HP:0001308)1.79580225
183Calcaneovalgus deformity (HP:0001848)1.79152045
184Hypertensive crisis (HP:0100735)1.78265114
185Abnormal number of erythroid precursors (HP:0012131)1.74011999
186Pathologic fracture (HP:0002756)1.73583703
187Microretrognathia (HP:0000308)1.72068984
188Bowing of the arm (HP:0006488)1.71973234
189Bowed forearm bones (HP:0003956)1.71973234
190Overriding aorta (HP:0002623)1.71551888
191Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71271586
192Spinal muscular atrophy (HP:0007269)1.70999312
193Neurodegeneration (HP:0002180)1.69712152
194Progressive external ophthalmoplegia (HP:0000590)1.66726791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC79.09608562
2SCYL24.80215380
3MAP3K144.32914896
4BUB14.25910256
5SMG13.35457601
6TYK23.12895102
7TBK12.99895617
8MAP4K12.91733536
9KIT2.69813944
10TAOK32.60422171
11JAK32.52823570
12BLK2.48499926
13IKBKB2.40188007
14IRAK42.30081980
15IKBKE2.25227971
16MAP3K132.12849239
17IRAK32.11556063
18MKNK22.01358870
19ERN12.00162438
20TGFBR21.99197467
21RIPK41.98112169
22ZAP701.91455036
23ILK1.90729759
24JAK11.86923987
25TXK1.86758100
26CDK71.83977233
27SRPK11.83726569
28SIK31.80088450
29NME21.79009602
30KSR21.75622817
31FGFR41.69026223
32SIK21.68574937
33TRIB31.66073529
34CHEK21.64837484
35RPS6KB21.62752943
36RPS6KA41.61609043
37AURKA1.56206538
38SYK1.52259590
39CHUK1.51517112
40BTK1.49654601
41TGFBR11.49242227
42CSF1R1.46936531
43MAP2K31.46845618
44KSR11.46267143
45RAF11.45439902
46CSK1.45406997
47ATR1.43835190
48PIM21.41925790
49TTK1.41516824
50HCK1.37674849
51EPHA31.37589003
52TEC1.37391101
53MUSK1.35622101
54MATK1.35185533
55EPHB11.32448391
56CAMK1D1.24347804
57PAK21.24241322
58CDK31.21953078
59MAP3K31.16705724
60ARAF1.16347622
61PLK41.15169893
62LCK1.14103989
63SIK11.12516558
64PLK31.12293019
65MAPK151.11751211
66BRSK21.04360651
67TAOK11.03503797
68PLK11.03011908
69RIPK11.02346976
70CHEK10.99220362
71MAP3K100.99135730
72PAK60.98307686
73FES0.97326290
74FLT30.97043127
75TRPM70.96700669
76MAP2K70.95815373
77PKN20.94027440
78LYN0.94001317
79FGFR30.93454496
80NEK90.93179661
81BMPR1B0.91628071
82ABL20.90799459
83BRSK10.89548660
84MST40.88648135
85JAK20.87859369
86CDK80.85648073
87CDC42BPA0.84152426
88CSNK1G30.81964626
89ADRBK20.81925750
90PIM10.81585430
91MTOR0.78649428
92ITK0.75068621
93CSNK1A1L0.74059606
94MKNK10.73593762
95ATM0.72513598
96FGR0.72346456
97RPS6KL10.71647091
98RPS6KC10.71647091
99MAP3K70.69196496
100STK100.66161734
101PRPF4B0.64626138
102BRD40.64517789
103EPHA20.64500171
104TTN0.64285821
105MAP3K10.64254549
106MAP3K80.64116111
107ALK0.63587797
108MAP3K110.61721717
109MARK30.58578232
110CAMK1G0.58394353
111MAP3K90.57596184
112MAP3K20.56496816
113PTK60.55519459
114PRKG20.54000526
115RPS6KA60.53466121
116CAMKK20.53108162
117CSNK1G10.52573592
118CDK20.52412211
119HIPK20.51865999
120GRK70.51002923
121RET0.50783505
122BRAF0.50660566
123RPS6KA10.50497099
124MOS0.50254054
125PRKD20.50104955
126EIF2AK20.48924284
127MAPK110.48447016
128IRAK10.48359665
129NEK20.48043218
130IRAK20.46927887
131MYLK0.45848790
132ICK0.45513546
133GRK10.43921469
134ABL10.43399885
135MAPKAPK20.42722355
136CDK40.42464178
137PBK0.42015701
138NLK0.40477666
139CDK90.39398591
140PDK10.39180696
141AKT30.38897736
142CSNK1G20.38803301
143DAPK10.38589746
144TAOK20.37988313
145STK40.37229415
146CLK10.36652058
147KDR0.36621684
148MAP2K60.36449525
149MAP3K50.36324798
150MELK0.36246513
151EEF2K0.36196325
152EIF2AK30.35932830
153PRKCD0.35671373
154CSNK2A10.34940534
155CDK60.33337350
156PRKAA20.32490182
157ZAK0.32452471
158PAK10.32052682
159BMX0.31168484
160EGFR0.30319732
161CDK120.29314801
162LRRK20.28017060
163RPS6KA50.27742532
164YES10.27560256
165CSNK2A20.27378986
166MAP3K40.26850017
167MST1R0.26697038
168STK110.26140244
169MAP3K120.24107278
170AURKB0.23585523
171DMPK0.21888688
172PRKDC0.21239243
173CDK10.20662857

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.82247639
2Mismatch repair_Homo sapiens_hsa034304.58442043
3Cell cycle_Homo sapiens_hsa041103.43761501
4Ribosome_Homo sapiens_hsa030103.24729148
5NF-kappa B signaling pathway_Homo sapiens_hsa040643.02722831
6Leishmaniasis_Homo sapiens_hsa051402.95615646
7Spliceosome_Homo sapiens_hsa030402.70917255
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.70657711
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.64926578
10Osteoclast differentiation_Homo sapiens_hsa043802.55182207
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55155892
12Primary immunodeficiency_Homo sapiens_hsa053402.53827919
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.48587119
14Nucleotide excision repair_Homo sapiens_hsa034202.43359991
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.32987298
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25405861
17Measles_Homo sapiens_hsa051622.24460491
18Pertussis_Homo sapiens_hsa051332.10023833
19Antigen processing and presentation_Homo sapiens_hsa046122.08042125
20TNF signaling pathway_Homo sapiens_hsa046682.04417324
21Staphylococcus aureus infection_Homo sapiens_hsa051502.01594891
22B cell receptor signaling pathway_Homo sapiens_hsa046621.99242017
23Tuberculosis_Homo sapiens_hsa051521.98828694
24Allograft rejection_Homo sapiens_hsa053301.98800296
25Legionellosis_Homo sapiens_hsa051341.98570198
26Herpes simplex infection_Homo sapiens_hsa051681.98016470
27Malaria_Homo sapiens_hsa051441.96451293
28Base excision repair_Homo sapiens_hsa034101.96067663
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95842810
30Bladder cancer_Homo sapiens_hsa052191.94279276
31Influenza A_Homo sapiens_hsa051641.90748910
32Homologous recombination_Homo sapiens_hsa034401.90657137
33Toxoplasmosis_Homo sapiens_hsa051451.86004124
34Graft-versus-host disease_Homo sapiens_hsa053321.84861244
35Other glycan degradation_Homo sapiens_hsa005111.83872340
36Basal transcription factors_Homo sapiens_hsa030221.83620197
37Rheumatoid arthritis_Homo sapiens_hsa053231.82246629
38Sulfur relay system_Homo sapiens_hsa041221.77952806
39Fanconi anemia pathway_Homo sapiens_hsa034601.74821170
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70799453
41Circadian rhythm_Homo sapiens_hsa047101.63911658
42Hematopoietic cell lineage_Homo sapiens_hsa046401.63679025
43Lysosome_Homo sapiens_hsa041421.61095096
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.58690000
45Salmonella infection_Homo sapiens_hsa051321.54920252
46Shigellosis_Homo sapiens_hsa051311.54626306
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52299452
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52012125
49RNA transport_Homo sapiens_hsa030131.49751750
50Asthma_Homo sapiens_hsa053101.46283893
51Apoptosis_Homo sapiens_hsa042101.44026116
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38891355
53Chemokine signaling pathway_Homo sapiens_hsa040621.38356734
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.34565749
55T cell receptor signaling pathway_Homo sapiens_hsa046601.32912963
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31348733
57Hepatitis B_Homo sapiens_hsa051611.27536838
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24646363
59Acute myeloid leukemia_Homo sapiens_hsa052211.21937954
60African trypanosomiasis_Homo sapiens_hsa051431.21778137
61Phagosome_Homo sapiens_hsa041451.21269288
62Type I diabetes mellitus_Homo sapiens_hsa049401.16510194
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11979054
64Hepatitis C_Homo sapiens_hsa051601.11751384
65Prion diseases_Homo sapiens_hsa050201.07521814
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04924286
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97611379
68Caffeine metabolism_Homo sapiens_hsa002320.97349911
69Non-small cell lung cancer_Homo sapiens_hsa052230.95710174
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94390838
71Colorectal cancer_Homo sapiens_hsa052100.94061346
72Autoimmune thyroid disease_Homo sapiens_hsa053200.93600162
73Viral myocarditis_Homo sapiens_hsa054160.92764602
74Prostate cancer_Homo sapiens_hsa052150.90174471
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.89097843
76MicroRNAs in cancer_Homo sapiens_hsa052060.88025471
77Epstein-Barr virus infection_Homo sapiens_hsa051690.87768594
78Oocyte meiosis_Homo sapiens_hsa041140.86884109
79Platelet activation_Homo sapiens_hsa046110.85080369
80Prolactin signaling pathway_Homo sapiens_hsa049170.84626104
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.74217587
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71537237
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68761564
84mRNA surveillance pathway_Homo sapiens_hsa030150.67751726
85TGF-beta signaling pathway_Homo sapiens_hsa043500.67328444
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67070480
87Chronic myeloid leukemia_Homo sapiens_hsa052200.65201253
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64858745
89Pancreatic cancer_Homo sapiens_hsa052120.64705911
90Hedgehog signaling pathway_Homo sapiens_hsa043400.63763678
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62533351
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61006345
93Amoebiasis_Homo sapiens_hsa051460.59548456
94mTOR signaling pathway_Homo sapiens_hsa041500.58982201
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58489279
96HTLV-I infection_Homo sapiens_hsa051660.58399529
97Viral carcinogenesis_Homo sapiens_hsa052030.55302342
98Glioma_Homo sapiens_hsa052140.54082291
99Small cell lung cancer_Homo sapiens_hsa052220.53654017
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.52529684
101Renal cell carcinoma_Homo sapiens_hsa052110.47517954
102Pyrimidine metabolism_Homo sapiens_hsa002400.46586442
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45771524
104RNA polymerase_Homo sapiens_hsa030200.45394290
105Insulin resistance_Homo sapiens_hsa049310.44109667
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43946904
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42904421
108Wnt signaling pathway_Homo sapiens_hsa043100.42043706
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42020852
110MAPK signaling pathway_Homo sapiens_hsa040100.40845644
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40212381
112Endometrial cancer_Homo sapiens_hsa052130.40016550
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39445856
114Notch signaling pathway_Homo sapiens_hsa043300.39137824
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.38697683
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37764898
117Phototransduction_Homo sapiens_hsa047440.37638668
118Lysine degradation_Homo sapiens_hsa003100.37374498
119FoxO signaling pathway_Homo sapiens_hsa040680.37359994
120p53 signaling pathway_Homo sapiens_hsa041150.36172204
121Melanoma_Homo sapiens_hsa052180.33017475
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32615582
123Thyroid cancer_Homo sapiens_hsa052160.31191164
124Complement and coagulation cascades_Homo sapiens_hsa046100.30603514
125Sphingolipid metabolism_Homo sapiens_hsa006000.29986536
126HIF-1 signaling pathway_Homo sapiens_hsa040660.29684096
127Type II diabetes mellitus_Homo sapiens_hsa049300.29509833
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29439287
129Regulation of autophagy_Homo sapiens_hsa041400.29260444
130Insulin signaling pathway_Homo sapiens_hsa049100.27778657
131GnRH signaling pathway_Homo sapiens_hsa049120.27718091
132Estrogen signaling pathway_Homo sapiens_hsa049150.27145531
133Collecting duct acid secretion_Homo sapiens_hsa049660.25526635
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25338125
135ABC transporters_Homo sapiens_hsa020100.24301587
136Proteoglycans in cancer_Homo sapiens_hsa052050.20794075
137Folate biosynthesis_Homo sapiens_hsa007900.19867275
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19829890
139Pathways in cancer_Homo sapiens_hsa052000.18929236
140Endocytosis_Homo sapiens_hsa041440.18662331
141Focal adhesion_Homo sapiens_hsa045100.15981762
142Inositol phosphate metabolism_Homo sapiens_hsa005620.15582064
143Renin-angiotensin system_Homo sapiens_hsa046140.15577308
144Protein export_Homo sapiens_hsa030600.15023708
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13578328
146Vibrio cholerae infection_Homo sapiens_hsa051100.13047004
147VEGF signaling pathway_Homo sapiens_hsa043700.13004164

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