TNK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.30213166
2hemidesmosome assembly (GO:0031581)9.27885587
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.13932310
4regulation of water loss via skin (GO:0033561)6.06977280
5intestinal epithelial cell development (GO:0060576)6.03726102
6interferon-gamma secretion (GO:0072643)5.87787713
7establishment of skin barrier (GO:0061436)5.60790804
8membrane budding (GO:0006900)5.46788780
9establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.43997935
10mitochondrion transport along microtubule (GO:0047497)5.43997935
11zinc ion transmembrane transport (GO:0071577)5.34159401
12peptidyl-arginine omega-N-methylation (GO:0035247)5.30068225
13tRNA methylation (GO:0030488)5.17252954
14negative regulation of keratinocyte proliferation (GO:0010839)5.17086431
15mannose metabolic process (GO:0006013)5.15658437
16succinate metabolic process (GO:0006105)5.06192683
17keratinocyte development (GO:0003334)4.87432021
18multicellular organismal water homeostasis (GO:0050891)4.49033565
19regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.41892347
20establishment of mitochondrion localization (GO:0051654)4.40642433
21regulation of chemokine secretion (GO:0090196)4.29552216
22peptidyl-arginine N-methylation (GO:0035246)4.26124715
23peptidyl-arginine methylation (GO:0018216)4.26124715
24glandular epithelial cell differentiation (GO:0002067)4.24415261
25intestinal cholesterol absorption (GO:0030299)4.08995353
26atrioventricular valve morphogenesis (GO:0003181)4.01575165
27calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.00552842
28intestinal absorption (GO:0050892)4.00534007
29negative regulation of cell fate specification (GO:0009996)3.98667006
30auditory receptor cell stereocilium organization (GO:0060088)3.98068642
31histone arginine methylation (GO:0034969)3.88179702
32positive regulation of lamellipodium assembly (GO:0010592)3.76800714
33epithelial cell differentiation involved in prostate gland development (GO:0060742)3.70331871
34positive regulation of lamellipodium organization (GO:1902745)3.67710998
35keratinocyte proliferation (GO:0043616)3.67326257
36columnar/cuboidal epithelial cell development (GO:0002066)3.64751235
37regulation of apoptotic process involved in morphogenesis (GO:1902337)3.59297770
38regulation of cell fate specification (GO:0042659)3.56392683
39water homeostasis (GO:0030104)3.56215275
40keratinocyte differentiation (GO:0030216)3.54982172
41positive regulation of epidermal cell differentiation (GO:0045606)3.52017537
42cardiac right ventricle morphogenesis (GO:0003215)3.50999760
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50679831
44tight junction assembly (GO:0070830)3.47969732
45regulation of keratinocyte proliferation (GO:0010837)3.47698533
46ectoderm development (GO:0007398)3.47497379
47negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.46318147
48peptidyl-histidine modification (GO:0018202)3.46037910
49regulation of hippo signaling (GO:0035330)3.35455565
50embryonic process involved in female pregnancy (GO:0060136)3.33730999
51regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.33578284
52long term synaptic depression (GO:0060292)3.33508219
53Golgi transport vesicle coating (GO:0048200)3.32770467
54COPI coating of Golgi vesicle (GO:0048205)3.32770467
55positive regulation of keratinocyte differentiation (GO:0045618)3.32192841
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30750068
57activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.30656465
58endocrine pancreas development (GO:0031018)3.25642582
59negative regulation of cell fate commitment (GO:0010454)3.25052393
60viral transcription (GO:0019083)3.23073054
61positive regulation of CREB transcription factor activity (GO:0032793)3.22180851
62protein targeting to ER (GO:0045047)3.21248380
63protein retention in ER lumen (GO:0006621)3.20470445
64protein complex localization (GO:0031503)3.19900991
65protein kinase C signaling (GO:0070528)3.19310443
66tRNA modification (GO:0006400)3.18849104
67regulation of gene silencing by RNA (GO:0060966)3.16405917
68regulation of posttranscriptional gene silencing (GO:0060147)3.16405917
69regulation of gene silencing by miRNA (GO:0060964)3.16405917
70cotranslational protein targeting to membrane (GO:0006613)3.15050901
71epidermal cell differentiation (GO:0009913)3.13376587
72zinc ion homeostasis (GO:0055069)3.12716322
73ribosomal small subunit biogenesis (GO:0042274)3.12656825
74apoptotic DNA fragmentation (GO:0006309)3.11710006
75translational termination (GO:0006415)3.10771198
76zinc ion transport (GO:0006829)3.09736506
77signal transduction involved in regulation of gene expression (GO:0023019)3.08501644
78cellular protein complex localization (GO:0034629)3.06666161
79ribosomal large subunit biogenesis (GO:0042273)3.04119546
80GDP-mannose metabolic process (GO:0019673)2.99520876
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98965303
82sphingoid metabolic process (GO:0046519)2.98497830
83primary alcohol catabolic process (GO:0034310)2.98100363
84regulation of cardioblast proliferation (GO:0003264)2.95365524
85regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95365524
86peptidyl-arginine modification (GO:0018195)2.94374636
87phenol-containing compound catabolic process (GO:0019336)2.94362029
88regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.94021129
89positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.94021129
90protein localization to endoplasmic reticulum (GO:0070972)2.93005394
91positive regulation of interleukin-8 secretion (GO:2000484)2.92831082
92peptide catabolic process (GO:0043171)2.91664748
93trophectodermal cell differentiation (GO:0001829)2.91209680
94regulation of cardioblast differentiation (GO:0051890)2.90585736
95epithelial cell-cell adhesion (GO:0090136)2.90005191
96positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.89880995
97keratinization (GO:0031424)2.88967904
98maturation of SSU-rRNA (GO:0030490)2.88300992
99maintenance of gastrointestinal epithelium (GO:0030277)2.86270223
100nucleotide-sugar biosynthetic process (GO:0009226)2.85782199
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.85025083
102positive regulation of epidermis development (GO:0045684)2.84658893
103tricarboxylic acid cycle (GO:0006099)2.84658765
104execution phase of apoptosis (GO:0097194)2.81757438
105regulation of keratinocyte differentiation (GO:0045616)2.81475388
106morphogenesis of embryonic epithelium (GO:0016331)2.81471668
107regulation of cholesterol homeostasis (GO:2000188)2.80703997
108mitochondrion localization (GO:0051646)2.80697039
109mammary gland alveolus development (GO:0060749)2.80650771
110positive regulation of protein homooligomerization (GO:0032464)2.79489925
111planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79488425
112pharyngeal system development (GO:0060037)2.78970720
113establishment of apical/basal cell polarity (GO:0035089)2.78292458
114diol metabolic process (GO:0034311)2.78049935
115epidermis development (GO:0008544)2.77566458
116regulation of lamellipodium assembly (GO:0010591)2.74077814
117regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.72427678
118activation of Rac GTPase activity (GO:0032863)2.72185710
119gland morphogenesis (GO:0022612)2.72021494
120phospholipid scrambling (GO:0017121)2.70731977
121negative regulation of protein oligomerization (GO:0032460)2.70114762
122positive regulation of mRNA catabolic process (GO:0061014)2.70061543
123ribosomal small subunit assembly (GO:0000028)2.69661144
124pentose metabolic process (GO:0019321)2.68836656
125antibacterial humoral response (GO:0019731)2.68690060
1263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.68106941
127purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.68106941
128sphingosine metabolic process (GO:0006670)2.66145718
129viral mRNA export from host cell nucleus (GO:0046784)2.65075160
130cell-substrate junction assembly (GO:0007044)2.64506797
131transcription from mitochondrial promoter (GO:0006390)2.64477103
132translational elongation (GO:0006414)2.62441963
133viral life cycle (GO:0019058)2.61657306
134pyrimidine-containing compound transmembrane transport (GO:0072531)2.61579643
135antimicrobial humoral response (GO:0019730)2.61513200
136cell differentiation involved in embryonic placenta development (GO:0060706)2.59101067
137regulation of interleukin-8 secretion (GO:2000482)2.58626801
138wound healing, spreading of epidermal cells (GO:0035313)2.57682655
139NADH metabolic process (GO:0006734)2.57351827
140cell-cell junction maintenance (GO:0045217)2.57041200
141innate immune response in mucosa (GO:0002227)2.56468010
142ear development (GO:0043583)2.56209748
143cellular response to vitamin D (GO:0071305)2.55409110
144positive regulation of icosanoid secretion (GO:0032305)2.55268254
145hormone catabolic process (GO:0042447)2.54736041
146regulation of lamellipodium organization (GO:1902743)2.54117102
147epithelial cell fate commitment (GO:0072148)2.53904491
148thymic T cell selection (GO:0045061)2.53853334
149negative regulation of cell aging (GO:0090344)2.53733333
150regulation of mRNA catabolic process (GO:0061013)2.51956405
151phosphatidylserine acyl-chain remodeling (GO:0036150)2.51525359
152positive regulation of mitochondrial fission (GO:0090141)2.50719622
153response to progesterone (GO:0032570)2.50284657
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49243259
155nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.48541303
156regulation of podosome assembly (GO:0071801)2.48158140
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.47887662
158regulation of cell proliferation involved in kidney development (GO:1901722)2.47834768
159hepatocyte apoptotic process (GO:0097284)2.47493690
160digestion (GO:0007586)2.47252767
161proline biosynthetic process (GO:0006561)2.47029216
162positive regulation of prostaglandin secretion (GO:0032308)2.46645546
163renal absorption (GO:0070293)2.46177494
164retrograde transport, endosome to Golgi (GO:0042147)2.44642819
165TOR signaling (GO:0031929)2.44351932
166glutathione biosynthetic process (GO:0006750)2.43567797
167branching involved in labyrinthine layer morphogenesis (GO:0060670)2.43561452
168homocysteine metabolic process (GO:0050667)2.42955723
169peptidyl-lysine dimethylation (GO:0018027)2.41886527
170positive regulation of cellular amine metabolic process (GO:0033240)2.41771074
171cellular response to prostaglandin stimulus (GO:0071379)2.40992662
172negative regulation of myotube differentiation (GO:0010832)2.40285634
173nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.40052372
174positive regulation of triglyceride lipase activity (GO:0061365)2.39760423
175positive regulation of lipoprotein lipase activity (GO:0051006)2.39760423
176positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.38383596
177regulation of bile acid biosynthetic process (GO:0070857)2.37509996
178cytoskeletal anchoring at plasma membrane (GO:0007016)2.36434328
179histone H4 deacetylation (GO:0070933)2.36432629
180negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.35509096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.64388608
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.45201335
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.30336765
4ESR1_15608294_ChIP-ChIP_MCF-7_Human2.83449188
5SRY_22984422_ChIP-ChIP_TESTIS_Rat2.74157879
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46116281
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31073103
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31073103
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31073103
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.29511482
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.24660403
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.17861268
13LXR_22292898_ChIP-Seq_THP-1_Human2.13154411
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.09478035
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09337636
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09102403
17P63_26484246_Chip-Seq_KERATINOCYTES_Human2.08452584
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07961392
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07961392
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07533377
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01025929
22* P68_20966046_ChIP-Seq_HELA_Human2.00625771
23TP63_17297297_ChIP-ChIP_HaCaT_Human14.6636581
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98130376
25GATA6_25053715_ChIP-Seq_YYC3_Human1.88699673
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88159848
27GATA4_25053715_ChIP-Seq_YYC3_Human1.87727908
28SOX2_20726797_ChIP-Seq_SW620_Human1.86573649
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85430145
30* TET1_21451524_ChIP-Seq_MESCs_Mouse1.83997782
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.83466752
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77750476
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.77409415
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.75423282
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.73510874
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72643819
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71902929
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68208125
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67903448
40* BCOR_27268052_Chip-Seq_Bcells_Human1.66479450
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.65943252
42VDR_21846776_ChIP-Seq_THP-1_Human1.63832326
43TCF7_22412390_ChIP-Seq_EML_Mouse1.62881898
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61953287
45E2F1_20622854_ChIP-Seq_HELA_Human1.60925527
46* ELF1_20517297_ChIP-Seq_JURKAT_Human1.60129240
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59490697
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59483810
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57585638
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55591729
51MYC_22102868_ChIP-Seq_BL_Human1.55359627
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53547315
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.53345529
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.49729389
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.48961137
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48377540
57* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46688109
58KLF5_25053715_ChIP-Seq_YYC3_Human1.46332158
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44274141
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43756875
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.42199605
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41459347
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38852099
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38732336
65ZNF263_19887448_ChIP-Seq_K562_Human1.38495117
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38364631
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36815059
68E2F7_22180533_ChIP-Seq_HELA_Human1.35616288
69RACK7_27058665_Chip-Seq_MCF-7_Human1.35442913
70* SMC4_20622854_ChIP-Seq_HELA_Human1.34954286
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34166745
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.32890931
73ATF3_27146783_Chip-Seq_COLON_Human1.32674993
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32060606
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31951944
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30859070
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30844069
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30321628
79* PHF8_20622854_ChIP-Seq_HELA_Human1.29748173
80GATA1_22025678_ChIP-Seq_K562_Human1.26840997
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26509660
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25956633
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25953057
84* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25228573
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24441550
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23944750
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23816529
88* KDM2B_26808549_Chip-Seq_DND41_Human1.22794444
89* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22735466
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21325837
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21250539
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.20606766
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20092110
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.19158253
95* BCL6_27268052_Chip-Seq_Bcells_Human1.18612315
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.18512796
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17922589
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17637096
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16807776
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.16507809
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16401512
102NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16385735
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16300603
104KDM2B_26808549_Chip-Seq_K562_Human1.14965373
105MAF_26560356_Chip-Seq_TH2_Human1.14948215
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14717763
107TP53_22127205_ChIP-Seq_IMR90_Human1.14706383
108* RARA_24833708_ChIP-Seq_LIVER_Mouse1.13332571
109CREB1_26743006_Chip-Seq_LNCaP_Human1.13298272
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12837392
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12556436
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11199034
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11027589
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10059645
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09819320
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.09148008
117CTCF_20526341_ChIP-Seq_ESCs_Human1.08302297
118GATA3_24758297_ChIP-Seq_MCF-7_Human1.08118388
119AR_21909140_ChIP-Seq_LNCAP_Human1.08078920
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08000857
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06960461
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06824285
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.04935037
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03251576
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02723309
126OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02594545
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02572488
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02520472
129CTCF_21964334_Chip-Seq_Bcells_Human1.01912892
130ETS1_21867929_ChIP-Seq_TH2_Mouse1.01542638
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01300782
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01210859
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00798735
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99950830
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98846235
136CTCF_27219007_Chip-Seq_Bcells_Human0.98718339
137* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98332277
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.98247010
139NCOR1_26117541_ChIP-Seq_K562_Human0.98163633
140KDM5A_27292631_Chip-Seq_BREAST_Human0.97917897
141* MAF_26560356_Chip-Seq_TH1_Human0.97436846
142* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97363671
143* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96570638
144STAT1_20625510_ChIP-Seq_HELA_Human0.96516452
145NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96188345
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94254667
147* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93928824
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91962387
149HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91408866
150PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90671435
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.90449353
152SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90274726
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88696243
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.88050210
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.85273015
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84732465
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83821265
158CHD1_26751641_Chip-Seq_LNCaP_Human0.83293829
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.83243212
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82953537
161KAP1_27257070_Chip-Seq_ESCs_Mouse0.82608820
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82200092
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80446060
164* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79795834
165* TP63_22573176_ChIP-Seq_HFKS_Human0.76183982
166JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75422029
167TP53_20018659_ChIP-ChIP_R1E_Mouse0.74684339
168NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74540536
169AHR_22903824_ChIP-Seq_MCF-7_Human0.73454415
170CLOCK_20551151_ChIP-Seq_293T_Human0.73217012
171* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73040118
172CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72923000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.20552422
2MP0003941_abnormal_skin_development3.74471587
3MP0009278_abnormal_bone_marrow3.68346102
4MP0002254_reproductive_system_inflammat3.60990325
5MP0002796_impaired_skin_barrier3.58690680
6MP0000566_synostosis3.12289227
7MP0008875_abnormal_xenobiotic_pharmacok3.07192502
8MP0000383_abnormal_hair_follicle2.94989115
9MP0004264_abnormal_extraembryonic_tissu2.94009034
10MP0010678_abnormal_skin_adnexa2.82776969
11MP0008260_abnormal_autophagy2.78617935
12MP0002098_abnormal_vibrissa_morphology2.73932494
13MP0003806_abnormal_nucleotide_metabolis2.63142959
14MP0010352_gastrointestinal_tract_polyps2.46523431
15MP0002060_abnormal_skin_morphology2.45609271
16MP0000678_abnormal_parathyroid_gland2.41396748
17MP0005360_urolithiasis2.39347057
18MP0003283_abnormal_digestive_organ2.35620848
19MP0003453_abnormal_keratinocyte_physiol2.33774194
20MP0005501_abnormal_skin_physiology2.29767243
21MP0000467_abnormal_esophagus_morphology2.22024487
22MP0005083_abnormal_biliary_tract2.19811241
23MP0001216_abnormal_epidermal_layer2.18485669
24MP0004233_abnormal_muscle_weight2.08875011
25MP0003191_abnormal_cellular_cholesterol2.08043946
26MP0002234_abnormal_pharynx_morphology2.01200128
27MP0000579_abnormal_nail_morphology1.98273461
28MP0000762_abnormal_tongue_morphology1.97365320
29MP0001849_ear_inflammation1.96679833
30MP0000462_abnormal_digestive_system1.93179318
31MP0004381_abnormal_hair_follicle1.90737032
32MP0005377_hearing/vestibular/ear_phenot1.88312866
33MP0003878_abnormal_ear_physiology1.88312866
34MP0005365_abnormal_bile_salt1.87745509
35MP0002877_abnormal_melanocyte_morpholog1.84396756
36MP0000613_abnormal_salivary_gland1.78034245
37MP0001346_abnormal_lacrimal_gland1.75124238
38MP0001666_abnormal_nutrient_absorption1.74083279
39MP0003693_abnormal_embryo_hatching1.71472227
40MP0003136_yellow_coat_color1.71356230
41MP0005058_abnormal_lysosome_morphology1.70553675
42MP0001545_abnormal_hematopoietic_system1.69640114
43MP0005397_hematopoietic_system_phenotyp1.69640114
44MP0008789_abnormal_olfactory_epithelium1.64010883
45MP0005275_abnormal_skin_tensile1.60850050
46MP0010771_integument_phenotype1.60020673
47MP0005409_darkened_coat_color1.57961672
48MP0003566_abnormal_cell_adhesion1.57809373
49MP0000377_abnormal_hair_follicle1.51703913
50MP0000427_abnormal_hair_cycle1.50788174
51MP0000537_abnormal_urethra_morphology1.46216425
52MP0009379_abnormal_foot_pigmentation1.44676013
53MP0000647_abnormal_sebaceous_gland1.43729385
54MP0005076_abnormal_cell_differentiation1.43728282
55MP0008004_abnormal_stomach_pH1.40532859
56MP0009333_abnormal_splenocyte_physiolog1.38626954
57MP0003718_maternal_effect1.35886382
58MP0005085_abnormal_gallbladder_physiolo1.34470966
59MP0003724_increased_susceptibility_to1.31923544
60MP0002277_abnormal_respiratory_mucosa1.31426012
61MP0000470_abnormal_stomach_morphology1.28575610
62MP0003303_peritoneal_inflammation1.26742720
63MP0001348_abnormal_lacrimal_gland1.25643968
64MP0003866_abnormal_defecation1.22758039
65MP0004043_abnormal_pH_regulation1.20449446
66MP0005499_abnormal_olfactory_system1.19069796
67MP0005394_taste/olfaction_phenotype1.19069796
68MP0001765_abnormal_ion_homeostasis1.17685160
69MP0000490_abnormal_crypts_of1.17462804
70MP0003763_abnormal_thymus_physiology1.17185255
71MP0000516_abnormal_urinary_system1.16999471
72MP0005367_renal/urinary_system_phenotyp1.16999471
73MP0003705_abnormal_hypodermis_morpholog1.16765730
74MP0004782_abnormal_surfactant_physiolog1.15771147
75MP0000627_abnormal_mammary_gland1.15680642
76MP0009643_abnormal_urine_homeostasis1.15642459
77MP0003119_abnormal_digestive_system1.12938375
78MP0001764_abnormal_homeostasis1.11957325
79MP0002138_abnormal_hepatobiliary_system1.11870731
80MP0002653_abnormal_ependyma_morphology1.11105929
81MP0010030_abnormal_orbit_morphology1.10605177
82MP0004947_skin_inflammation1.10199088
83MP0005220_abnormal_exocrine_pancreas1.10192374
84* MP0001191_abnormal_skin_condition1.06549302
85MP0006054_spinal_hemorrhage1.01170418
86MP0000477_abnormal_intestine_morphology1.00015558
87MP0009840_abnormal_foam_cell0.99960079
88MP0009931_abnormal_skin_appearance0.99874320
89MP0000538_abnormal_urinary_bladder0.98863525
90MP0003656_abnormal_erythrocyte_physiolo0.97240193
91MP0004957_abnormal_blastocyst_morpholog0.96914067
92MP0002693_abnormal_pancreas_physiology0.94580920
93MP0003436_decreased_susceptibility_to0.94295632
94MP0002009_preneoplasia0.93835161
95MP0009053_abnormal_anal_canal0.93079319
96MP0005636_abnormal_mineral_homeostasis0.92517596
97MP0003890_abnormal_embryonic-extraembry0.91717093
98MP0002111_abnormal_tail_morphology0.91596577
99MP0003183_abnormal_peptide_metabolism0.91071902
100* MP0001944_abnormal_pancreas_morphology0.87681364
101MP0009780_abnormal_chondrocyte_physiolo0.87592838
102MP0000751_myopathy0.85486202
103MP0004742_abnormal_vestibular_system0.85462942
104MP0000465_gastrointestinal_hemorrhage0.84745135
105MP0010155_abnormal_intestine_physiology0.84161583
106MP0005257_abnormal_intraocular_pressure0.83731712
107MP0002132_abnormal_respiratory_system0.83375584
108MP0008057_abnormal_DNA_replication0.80421257
109MP0004019_abnormal_vitamin_homeostasis0.79404904
110MP0000367_abnormal_coat/_hair0.79106987
111MP0001664_abnormal_digestion0.78804649
112MP0009384_cardiac_valve_regurgitation0.76737587
113MP0003936_abnormal_reproductive_system0.74645494
114MP0005621_abnormal_cell_physiology0.73821189
115MP0002233_abnormal_nose_morphology0.72350838
116MP0006072_abnormal_retinal_apoptosis0.72325785
117MP0001873_stomach_inflammation0.72323488
118MP0008007_abnormal_cellular_replicative0.72276912
119MP0004130_abnormal_muscle_cell0.71530236
120MP0000003_abnormal_adipose_tissue0.70948146
121MP0001919_abnormal_reproductive_system0.70709996
122MP0002249_abnormal_larynx_morphology0.70150289
123MP0002751_abnormal_autonomic_nervous0.69141356
124MP0005023_abnormal_wound_healing0.67890172
125MP0001851_eye_inflammation0.67691033
126MP0002136_abnormal_kidney_physiology0.66363210
127MP0000681_abnormal_thyroid_gland0.65782417
128MP0005408_hypopigmentation0.65165328
129MP0000049_abnormal_middle_ear0.65110162
130MP0000858_altered_metastatic_potential0.64743038
131MP0004133_heterotaxia0.64441429
132MP0001881_abnormal_mammary_gland0.63401023
133MP0000432_abnormal_head_morphology0.63351122
134MP0002177_abnormal_outer_ear0.63240720
135MP0003300_gastrointestinal_ulcer0.62507069
136MP0005381_digestive/alimentary_phenotyp0.62336307
137MP0002896_abnormal_bone_mineralization0.61520745
138MP0003755_abnormal_palate_morphology0.61433427
139MP0000747_muscle_weakness0.60434985
140MP0002089_abnormal_postnatal_growth/wei0.59645686
141MP0002332_abnormal_exercise_endurance0.59176317
142MP0010329_abnormal_lipoprotein_level0.59006737
143MP0005332_abnormal_amino_acid0.58625283
144MP0000609_abnormal_liver_physiology0.56777004
145MP0004197_abnormal_fetal_growth/weight/0.56474606
146MP0000733_abnormal_muscle_development0.54896901

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)7.28959533
2Milia (HP:0001056)6.54346122
3Onycholysis (HP:0001806)5.79521519
4Fragile nails (HP:0001808)5.40664397
5Right ventricular cardiomyopathy (HP:0011663)5.05504514
6Pili torti (HP:0003777)4.98282244
7Atrophic scars (HP:0001075)4.86860389
8Seborrheic dermatitis (HP:0001051)4.63840122
9Plantar hyperkeratosis (HP:0007556)4.60388690
10Abnormality of nail color (HP:0100643)4.59959070
11Lip pit (HP:0100267)4.34675968
12Dicarboxylic aciduria (HP:0003215)4.24202284
13Abnormality of dicarboxylic acid metabolism (HP:0010995)4.24202284
14Absent rod-and cone-mediated responses on ERG (HP:0007688)4.16143520
15Decreased central vision (HP:0007663)4.02632307
16Methylmalonic aciduria (HP:0012120)3.90359232
17Hyperthyroidism (HP:0000836)3.49671124
18Hypotrichosis (HP:0001006)3.45074357
19Hypoplasia of dental enamel (HP:0006297)3.41987468
20Hyperventilation (HP:0002883)3.41507623
21Hypochromic anemia (HP:0001931)3.41219048
22Progressive muscle weakness (HP:0003323)3.40762203
23Woolly hair (HP:0002224)3.37998639
24Esophageal atresia (HP:0002032)3.32470881
25Hypertensive crisis (HP:0100735)3.26461338
26Aplasia cutis congenita (HP:0001057)3.13246652
27Nail dystrophy (HP:0008404)3.12766559
28Abnormal blistering of the skin (HP:0008066)3.05956674
29Popliteal pterygium (HP:0009756)3.04708580
30Curly hair (HP:0002212)3.01747671
31Unilateral renal agenesis (HP:0000122)3.00880746
32Pustule (HP:0200039)2.92818881
33Abnormal hemoglobin (HP:0011902)2.91871547
34Fatigable weakness (HP:0003473)2.86032795
35Abnormality of the neuromuscular junction (HP:0003398)2.86032795
36Hypoplastic labia majora (HP:0000059)2.79586859
37Palmoplantar hyperkeratosis (HP:0000972)2.77563217
38Palmar hyperkeratosis (HP:0010765)2.72825517
39Symptomatic seizures (HP:0011145)2.71880543
40Aplasia/hypoplasia of the uterus (HP:0008684)2.70736576
41Hypoparathyroidism (HP:0000829)2.66519282
42Abnormal hair laboratory examination (HP:0003328)2.59721694
43Fragile skin (HP:0001030)2.58540425
44Sparse eyelashes (HP:0000653)2.58494503
45Absent eyebrow (HP:0002223)2.57159741
46Biliary tract neoplasm (HP:0100574)2.56869849
47Stroke (HP:0001297)2.56368449
48Hypoplasia of the uterus (HP:0000013)2.56112949
49Pterygium (HP:0001059)2.50714193
50Poikiloderma (HP:0001029)2.50041215
51Ridged nail (HP:0001807)2.48884160
52Congenital sensorineural hearing impairment (HP:0008527)2.47677423
53Abnormality of the labia majora (HP:0012881)2.45987053
54Septate vagina (HP:0001153)2.45563183
55Atelectasis (HP:0100750)2.45445224
56Parakeratosis (HP:0001036)2.44938730
57Hyperactive renin-angiotensin system (HP:0000841)2.44303979
58Blepharitis (HP:0000498)2.43965028
59Easy fatigability (HP:0003388)2.42672152
60Trismus (HP:0000211)2.42036183
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41815258
62Hemorrhage of the eye (HP:0011885)2.41009234
63Hypophosphatemia (HP:0002148)2.39092939
64Truncus arteriosus (HP:0001660)2.38903764
65Abnormality of the gastric mucosa (HP:0004295)2.37046068
66Abnormal rod and cone electroretinograms (HP:0008323)2.36180645
67Abnormal biliary tract morphology (HP:0012440)2.34136646
68Abnormality of cells of the erythroid lineage (HP:0012130)2.33981514
69Malnutrition (HP:0004395)2.33380804
70Distal upper limb amyotrophy (HP:0007149)2.30924536
71Upper limb amyotrophy (HP:0009129)2.30924536
72Stomach cancer (HP:0012126)2.30856140
73Gastrointestinal atresia (HP:0002589)2.29676903
74Hand muscle atrophy (HP:0009130)2.29138777
7511 pairs of ribs (HP:0000878)2.29081630
76Abnormality of the salivary glands (HP:0010286)2.26881234
77Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.26281932
78Increased serum ferritin (HP:0003281)2.22901433
79Upper limb muscle weakness (HP:0003484)2.22358024
80Reticulocytopenia (HP:0001896)2.21149349
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19072572
82Selective tooth agenesis (HP:0001592)2.18922529
83Abnormal pancreas size (HP:0012094)2.18739878
84Villous atrophy (HP:0011473)2.16159328
85Abnormality of small intestinal villus morphology (HP:0011472)2.16159328
86Broad face (HP:0000283)2.14744009
87Alopecia of scalp (HP:0002293)2.12865425
88Flat acetabular roof (HP:0003180)2.12522012
89Dehydration (HP:0001944)2.08384422
90Attenuation of retinal blood vessels (HP:0007843)2.07678144
91Hyponatremia (HP:0002902)2.06966691
92Renal salt wasting (HP:0000127)2.05913091
93Hyperparathyroidism (HP:0000843)2.05263098
94Acanthosis nigricans (HP:0000956)2.04738159
95Ketoacidosis (HP:0001993)2.04718554
96Abdominal distention (HP:0003270)2.03542599
97Hypohidrosis (HP:0000966)2.02373770
98Hypocalcemia (HP:0002901)2.02028178
99Hyperphosphatemia (HP:0002905)2.01404808
100Abnormal number of erythroid precursors (HP:0012131)2.00045815
101Foot dorsiflexor weakness (HP:0009027)2.00023433
102Thin bony cortex (HP:0002753)1.99383329
103Hyperinsulinemic hypoglycemia (HP:0000825)1.98565784
104Abnormality of the distal phalanges of the toes (HP:0010182)1.97670321
105Flat capital femoral epiphysis (HP:0003370)1.97476969
106Fasciculations (HP:0002380)1.97413947
107Rectal prolapse (HP:0002035)1.96780612
108Ankyloglossia (HP:0010296)1.96683647
109Distal lower limb muscle weakness (HP:0009053)1.96591269
110Shawl scrotum (HP:0000049)1.96326358
111Generalized amyotrophy (HP:0003700)1.96233012
112Abnormal sex determination (HP:0012244)1.96001815
113Sex reversal (HP:0012245)1.96001815
114Skin pits (HP:0100276)1.95971222
115Stenosis of the external auditory canal (HP:0000402)1.95860796
116Amelogenesis imperfecta (HP:0000705)1.95182501
117Congenital ichthyosiform erythroderma (HP:0007431)1.94911218
118Anonychia (HP:0001798)1.94575408
119Bony spicule pigmentary retinopathy (HP:0007737)1.93956988
120Nasal polyposis (HP:0100582)1.93437510
121Cheilitis (HP:0100825)1.93196678
122Colon cancer (HP:0003003)1.92658399
123Ulnar bowing (HP:0003031)1.92216355
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90451132
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90168732
126Premature loss of primary teeth (HP:0006323)1.87901352
127Sparse lateral eyebrow (HP:0005338)1.87552443
128Ectropion (HP:0000656)1.87383896
129Corneal erosion (HP:0200020)1.86820241
130Hypoglycemic seizures (HP:0002173)1.86617633
131Patellar dislocation (HP:0002999)1.86533299
132Ureteral stenosis (HP:0000071)1.85886573
133Carious teeth (HP:0000670)1.83336411
134Hyperaldosteronism (HP:0000859)1.83252428
135Down-sloping shoulders (HP:0200021)1.83227181
136Entropion (HP:0000621)1.82998324
137Insulin-resistant diabetes mellitus (HP:0000831)1.82024112
138Anal stenosis (HP:0002025)1.81622667
139Severe visual impairment (HP:0001141)1.81271456
140Hypodontia (HP:0000668)1.81029225
141Ureteral obstruction (HP:0006000)1.80026156
142Squamous cell carcinoma (HP:0002860)1.79221133
143Aplasia involving bones of the extremities (HP:0009825)1.78359527
144Aplasia involving bones of the upper limbs (HP:0009823)1.78359527
145Aplasia of the phalanges of the hand (HP:0009802)1.78359527
146Hydroxyprolinuria (HP:0003080)1.78220520
147Abnormality of proline metabolism (HP:0010907)1.78220520
148Thick nail (HP:0001805)1.77355672
149Absent eyelashes (HP:0000561)1.77354890
150Micronodular cirrhosis (HP:0001413)1.77140084
151Abnormality of iron homeostasis (HP:0011031)1.76572038
152Abnormality of chloride homeostasis (HP:0011422)1.76026518
153Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75931871
154Natal tooth (HP:0000695)1.75916629
155Breast carcinoma (HP:0003002)1.75279797
156Double outlet right ventricle (HP:0001719)1.74303620
157Congenital malformation of the right heart (HP:0011723)1.74303620
158Slender long bone (HP:0003100)1.74123999
159Oligodontia (HP:0000677)1.72939493
160Sparse scalp hair (HP:0002209)1.72870680
161Abnormality of the nasal mucosa (HP:0000433)1.72340236
162Labial hypoplasia (HP:0000066)1.71979427
163Malignant gastrointestinal tract tumors (HP:0006749)1.70419263
164Gastrointestinal carcinoma (HP:0002672)1.70419263
165Uterine neoplasm (HP:0010784)1.70129823
166Exocrine pancreatic insufficiency (HP:0001738)1.69227575
167Missing ribs (HP:0000921)1.68049904
168Widely patent fontanelles and sutures (HP:0004492)1.67968648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.51254381
2EPHA26.03214740
3MST44.48870518
4MST1R4.44927856
5MAPK153.51039623
6TRIB33.27075389
7SMG13.16247085
8SIK12.94626503
9MAP3K32.93750136
10MAP2K22.69356104
11MAPKAPK32.66993555
12PASK2.61835696
13RPS6KB22.50037173
14AKT32.47447456
15MAP3K22.46408323
16FRK2.45284950
17MET2.25710810
18EPHA32.04289165
19STK382.03876042
20FER1.88175658
21PRKD21.86584669
22PTK2B1.83676004
23MUSK1.63913174
24GRK61.60238220
25NME11.54687479
26NEK11.52969109
27RPS6KC11.52289341
28RPS6KL11.52289341
29RPS6KA61.50176451
30JAK31.49742190
31MAP3K11.47800083
32PRKCI1.45250118
33ZAK1.44551548
34INSRR1.41960845
35IRAK31.41704236
36ERBB31.35296309
37STK101.34890984
38MAPK111.32745112
39RET1.29463186
40NME21.27120961
41EPHB21.24777946
42TTK1.21395810
43LATS11.21363327
44ERN11.20675507
45NLK1.19812737
46WNK41.16742474
47CDK121.12309138
48RPS6KA21.09171904
49BMX1.08611850
50PKN21.07172996
51CHUK1.06170277
52TESK21.01629535
53TNK21.01342988
54RIPK10.96400861
55BMPR1B0.94325423
56IRAK10.93044215
57MAP3K140.91761201
58PIK3CA0.90864792
59DYRK1B0.90676665
60SIK30.90114338
61PBK0.89315327
62TBK10.88831562
63PTK60.88099262
64HIPK20.88059530
65NEK60.87086884
66GRK10.85793096
67MTOR0.84362251
68TESK10.82299962
69AURKB0.81058977
70STK38L0.81038728
71PIM20.79396610
72MAP3K70.76437423
73TGFBR10.75587149
74ERBB40.75041717
75MAP2K60.73871099
76CDK90.72957359
77PTK20.72843944
78PLK40.72376473
79BRAF0.70029364
80EPHB10.69529133
81KDR0.68964322
82VRK10.65936828
83TRPM70.65108725
84TAOK30.64929219
85NTRK10.64593904
86CDK30.64460277
87NEK20.64057870
88MAP3K80.62868663
89MAPKAPK20.62771128
90LRRK20.62115759
91VRK20.61001118
92EIF2AK30.59990902
93CDK70.57090450
94MAP2K10.56783209
95EEF2K0.56444608
96ZAP700.56388158
97YES10.56162961
98BMPR20.54780756
99SRPK10.54431078
100WNK30.53757304
101PRKG20.53105376
102MARK20.51974878
103MAP4K10.51866932
104MATK0.49726604
105CDC42BPA0.47320754
106PIK3CG0.46914496
107CDK80.46600566
108PRKD30.45939817
109MELK0.44565758
110EIF2AK20.42482488
111ERBB20.41534399
112FGFR40.41476952
113PRPF4B0.41182667
114PDPK10.39702317
115TAOK20.39483800
116BTK0.38313458
117CDK60.38071469
118LMTK20.37928052
119ILK0.37710766
120STK240.37087961
121AURKA0.37055084
122IKBKB0.36014099
123DYRK30.35506212
124RPS6KA50.34991576
125DDR20.32740076
126PRKCE0.32737584
127IRAK40.31883586
128MAPK80.30748559
129BRD40.30566270
130RPS6KA10.29918299
131PRKAA10.29639564
132STK160.29408000
133MAP3K110.28967671
134TSSK60.28217249
135PLK30.26917819
136IKBKE0.26877227
137RPS6KA40.25999227
138PAK40.25756919
139TGFBR20.25668873
140PLK10.25517396
141FLT30.24901393
142MAPK30.24674057
143BRSK20.24669738
144CDK40.24214559
145GSK3A0.23417835
146FGFR30.23143099
147FYN0.23052039
148PDGFRA0.22444125
149MAPK70.21372552
150MAPKAPK50.21302508
151SRC0.20347501
152PDK10.19745808
153RPS6KB10.17411005
154MAPK10.16042711
155PRKD10.15024207

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.29261071
2Sulfur metabolism_Homo sapiens_hsa009204.13109023
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.69939000
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61791154
5Ribosome_Homo sapiens_hsa030102.64420609
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.64159734
7Protein export_Homo sapiens_hsa030602.29996409
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25698083
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.21836231
10Pentose phosphate pathway_Homo sapiens_hsa000302.21303188
11Fat digestion and absorption_Homo sapiens_hsa049752.13355837
12Mineral absorption_Homo sapiens_hsa049782.11048434
13Biosynthesis of amino acids_Homo sapiens_hsa012301.93355935
14Protein digestion and absorption_Homo sapiens_hsa049741.90245680
15Linoleic acid metabolism_Homo sapiens_hsa005911.89334638
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88143319
17Basal cell carcinoma_Homo sapiens_hsa052171.87679492
18Arachidonic acid metabolism_Homo sapiens_hsa005901.86061265
19Tyrosine metabolism_Homo sapiens_hsa003501.85947146
20Vitamin digestion and absorption_Homo sapiens_hsa049771.62961296
21Bladder cancer_Homo sapiens_hsa052191.52460105
22Sulfur relay system_Homo sapiens_hsa041221.51723407
23Folate biosynthesis_Homo sapiens_hsa007901.48565752
24Adherens junction_Homo sapiens_hsa045201.47405053
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.46949874
26Carbon metabolism_Homo sapiens_hsa012001.43624725
27Tight junction_Homo sapiens_hsa045301.42182010
28Galactose metabolism_Homo sapiens_hsa000521.41838438
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41671987
30mTOR signaling pathway_Homo sapiens_hsa041501.37766135
31Hippo signaling pathway_Homo sapiens_hsa043901.36775362
32Pancreatic secretion_Homo sapiens_hsa049721.36488684
33Glutathione metabolism_Homo sapiens_hsa004801.36081363
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33108777
35Thyroid cancer_Homo sapiens_hsa052161.28125502
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.25932416
37Fructose and mannose metabolism_Homo sapiens_hsa000511.25646286
38Arginine biosynthesis_Homo sapiens_hsa002201.22994540
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22966179
40Caffeine metabolism_Homo sapiens_hsa002321.22413181
41Notch signaling pathway_Homo sapiens_hsa043301.18036576
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17931944
43Hedgehog signaling pathway_Homo sapiens_hsa043401.17376470
44p53 signaling pathway_Homo sapiens_hsa041151.17010851
45AMPK signaling pathway_Homo sapiens_hsa041521.12691045
46Sphingolipid metabolism_Homo sapiens_hsa006001.11840355
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11018478
48ECM-receptor interaction_Homo sapiens_hsa045121.09780482
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09647371
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09019933
51Vibrio cholerae infection_Homo sapiens_hsa051101.08763134
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06674466
53Histidine metabolism_Homo sapiens_hsa003401.04153522
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.03246731
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02565212
56Acute myeloid leukemia_Homo sapiens_hsa052211.00445037
57Lysine degradation_Homo sapiens_hsa003101.00064863
58Small cell lung cancer_Homo sapiens_hsa052220.98777201
59Non-small cell lung cancer_Homo sapiens_hsa052230.94827397
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94486734
61Phenylalanine metabolism_Homo sapiens_hsa003600.93297624
62Legionellosis_Homo sapiens_hsa051340.92047024
63N-Glycan biosynthesis_Homo sapiens_hsa005100.87539771
64Inositol phosphate metabolism_Homo sapiens_hsa005620.84711573
65Insulin signaling pathway_Homo sapiens_hsa049100.83337358
66TGF-beta signaling pathway_Homo sapiens_hsa043500.82701311
67Propanoate metabolism_Homo sapiens_hsa006400.82603104
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80306696
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78833891
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78049583
71Base excision repair_Homo sapiens_hsa034100.77764111
72Hepatitis C_Homo sapiens_hsa051600.77500428
73One carbon pool by folate_Homo sapiens_hsa006700.77010855
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74514595
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74122854
76ABC transporters_Homo sapiens_hsa020100.74043914
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73440530
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73393340
79Renin-angiotensin system_Homo sapiens_hsa046140.73294552
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72803728
81RNA polymerase_Homo sapiens_hsa030200.72433506
82Spliceosome_Homo sapiens_hsa030400.72385128
83Amoebiasis_Homo sapiens_hsa051460.72234284
84Circadian rhythm_Homo sapiens_hsa047100.68674850
85Choline metabolism in cancer_Homo sapiens_hsa052310.68228424
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68207377
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68150688
88Chronic myeloid leukemia_Homo sapiens_hsa052200.67687797
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66093986
90Insulin resistance_Homo sapiens_hsa049310.65401912
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.65320642
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64049586
93Chemical carcinogenesis_Homo sapiens_hsa052040.63237783
94Fatty acid elongation_Homo sapiens_hsa000620.62519114
95Nitrogen metabolism_Homo sapiens_hsa009100.62349151
96Fanconi anemia pathway_Homo sapiens_hsa034600.61741052
97Nucleotide excision repair_Homo sapiens_hsa034200.60866076
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60621264
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59616184
100Glycerolipid metabolism_Homo sapiens_hsa005610.59448471
101Toxoplasmosis_Homo sapiens_hsa051450.58845894
102RNA transport_Homo sapiens_hsa030130.58531043
103Other glycan degradation_Homo sapiens_hsa005110.58364180
104Wnt signaling pathway_Homo sapiens_hsa043100.58285307
105VEGF signaling pathway_Homo sapiens_hsa043700.57579025
106Thyroid hormone synthesis_Homo sapiens_hsa049180.57339525
107Pyrimidine metabolism_Homo sapiens_hsa002400.56738383
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54454375
109Endometrial cancer_Homo sapiens_hsa052130.53688535
110beta-Alanine metabolism_Homo sapiens_hsa004100.52949496
111TNF signaling pathway_Homo sapiens_hsa046680.52725992
112Insulin secretion_Homo sapiens_hsa049110.52473784
113Homologous recombination_Homo sapiens_hsa034400.52371510
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.51824867
115Pathways in cancer_Homo sapiens_hsa052000.51421697
116Influenza A_Homo sapiens_hsa051640.50968394
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.50224045
118Bile secretion_Homo sapiens_hsa049760.48625773
119Selenocompound metabolism_Homo sapiens_hsa004500.48552477
120Apoptosis_Homo sapiens_hsa042100.48465271
121HTLV-I infection_Homo sapiens_hsa051660.47264305
122Ovarian steroidogenesis_Homo sapiens_hsa049130.45968828
123Starch and sucrose metabolism_Homo sapiens_hsa005000.44446822
124Arginine and proline metabolism_Homo sapiens_hsa003300.44244811
125Ether lipid metabolism_Homo sapiens_hsa005650.44189549
126MicroRNAs in cancer_Homo sapiens_hsa052060.43789087
127Collecting duct acid secretion_Homo sapiens_hsa049660.42759606
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39974358
129Melanoma_Homo sapiens_hsa052180.38968058
130Prostate cancer_Homo sapiens_hsa052150.38053463
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37829115
132Peroxisome_Homo sapiens_hsa041460.36866278
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36854981
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.36633278
135Prolactin signaling pathway_Homo sapiens_hsa049170.35510302
136Proteoglycans in cancer_Homo sapiens_hsa052050.35313624
137Fatty acid degradation_Homo sapiens_hsa000710.35269495
138ErbB signaling pathway_Homo sapiens_hsa040120.34022477
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33923440
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32801863
141Hematopoietic cell lineage_Homo sapiens_hsa046400.32722048
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32412995
143Mismatch repair_Homo sapiens_hsa034300.32262052
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32125696
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32014871
146PPAR signaling pathway_Homo sapiens_hsa033200.30340511
147Retinol metabolism_Homo sapiens_hsa008300.29805136
148Pertussis_Homo sapiens_hsa051330.28852744
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27415518
150Metabolic pathways_Homo sapiens_hsa011000.27316769
151Measles_Homo sapiens_hsa051620.25891965

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