TNK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.00208909
2locomotory exploration behavior (GO:0035641)5.73359135
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67446227
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95919653
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.83126650
6negative regulation of erythrocyte differentiation (GO:0045647)4.77312809
7sodium ion export (GO:0071436)4.71667329
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67074145
9layer formation in cerebral cortex (GO:0021819)4.51475780
10glutamate secretion (GO:0014047)4.38685677
11vocalization behavior (GO:0071625)4.23138629
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21975069
13negative regulation of cell killing (GO:0031342)4.21975069
14synaptic vesicle exocytosis (GO:0016079)4.19826273
15regulation of synaptic vesicle exocytosis (GO:2000300)4.17409658
16cellular potassium ion homeostasis (GO:0030007)4.07795598
17cytoskeletal anchoring at plasma membrane (GO:0007016)4.02996702
18neurotransmitter secretion (GO:0007269)3.97820195
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.97129831
20regulation of neuronal synaptic plasticity (GO:0048168)3.93682243
21regulation of synapse structural plasticity (GO:0051823)3.88049419
22exploration behavior (GO:0035640)3.84486414
23neuromuscular process controlling balance (GO:0050885)3.84154217
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83035540
25glycine transport (GO:0015816)3.82740058
26regulation of glutamate receptor signaling pathway (GO:1900449)3.81607577
27activation of protein kinase A activity (GO:0034199)3.68919630
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68592049
29dendritic spine morphogenesis (GO:0060997)3.68424380
30positive regulation of gamma-delta T cell activation (GO:0046645)3.60913852
31mannose metabolic process (GO:0006013)3.58586330
32neuromuscular process controlling posture (GO:0050884)3.57005623
33regulation of synaptic vesicle transport (GO:1902803)3.55880061
34proline transport (GO:0015824)3.53064556
35positive regulation of Rap GTPase activity (GO:0032854)3.48373356
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46975642
37peptidyl-tyrosine autophosphorylation (GO:0038083)3.46843813
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42879208
39cell communication by electrical coupling (GO:0010644)3.38621253
40neuronal action potential propagation (GO:0019227)3.37004201
41gamma-aminobutyric acid transport (GO:0015812)3.34660746
42cerebellar Purkinje cell layer development (GO:0021680)3.34255281
43prepulse inhibition (GO:0060134)3.32732603
44regulation of ARF protein signal transduction (GO:0032012)3.32339362
45antigen processing and presentation of endogenous antigen (GO:0019883)3.30460703
46positive thymic T cell selection (GO:0045059)3.29988721
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.29309665
48protein localization to synapse (GO:0035418)3.28914370
49establishment of nucleus localization (GO:0040023)3.26992501
50positive regulation of synapse maturation (GO:0090129)3.26232055
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23273303
52positive regulation of fibroblast migration (GO:0010763)3.21482901
53cerebellar Purkinje cell differentiation (GO:0021702)3.20009662
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.17885221
55thymic T cell selection (GO:0045061)3.16175989
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13868298
57long-term memory (GO:0007616)3.13707213
58response to muramyl dipeptide (GO:0032495)3.12554852
59regulation of dendritic spine morphogenesis (GO:0061001)3.09994531
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02896547
61potassium ion import (GO:0010107)3.02659072
62regulation of gamma-delta T cell activation (GO:0046643)3.02390616
63neurotransmitter transport (GO:0006836)3.01042446
64regulation of synaptic plasticity (GO:0048167)2.99840119
65potassium ion homeostasis (GO:0055075)2.99342851
66leukocyte aggregation (GO:0070486)2.96513522
67cerebellar granule cell differentiation (GO:0021707)2.96143046
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95245827
69detection of bacterium (GO:0016045)2.93538767
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93065178
71germinal center formation (GO:0002467)2.92532536
72stress fiber assembly (GO:0043149)2.90675347
73regulation of gamma-delta T cell differentiation (GO:0045586)2.90493865
74regulation of Rap GTPase activity (GO:0032317)2.89992064
75synaptic vesicle endocytosis (GO:0048488)2.88615703
76macrophage activation involved in immune response (GO:0002281)2.88514690
77synaptic transmission, glutamatergic (GO:0035249)2.88442475
78signal complex assembly (GO:0007172)2.88135203
79detection of other organism (GO:0098543)2.87964491
80regulation of ARF GTPase activity (GO:0032312)2.87273657
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86013435
82vesicle transport along microtubule (GO:0047496)2.85360974
83dendrite morphogenesis (GO:0048813)2.85301397
84plasma membrane repair (GO:0001778)2.84475370
85neuronal ion channel clustering (GO:0045161)2.82137824
86regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80980631
87cellular sodium ion homeostasis (GO:0006883)2.80784604
88amino acid import (GO:0043090)2.80545115
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80415031
90regulation of neurotransmitter levels (GO:0001505)2.78834547
91positive regulation of histone deacetylation (GO:0031065)2.77773402
92neuromuscular process (GO:0050905)2.77273294
93cell migration in hindbrain (GO:0021535)2.76226519
94positive regulation of membrane potential (GO:0045838)2.76066703
95T cell selection (GO:0045058)2.74153718
96auditory behavior (GO:0031223)2.74065365
97regulation of leukocyte degranulation (GO:0043300)2.73658170
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72543993
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71516607
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.71516607
101modulation by symbiont of host immune response (GO:0052553)2.71516607
102positive regulation by symbiont of host defense response (GO:0052509)2.71516607
103modulation by symbiont of host defense response (GO:0052031)2.71516607
104modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71516607
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71511990
106dendritic spine organization (GO:0097061)2.70637844
107regulation of regulated secretory pathway (GO:1903305)2.70097158
108neuron-neuron synaptic transmission (GO:0007270)2.69141818
109neurotransmitter-gated ion channel clustering (GO:0072578)2.69003907
110L-amino acid import (GO:0043092)2.68643592
111glutamate receptor signaling pathway (GO:0007215)2.68106641
112regulation of T-helper 2 cell differentiation (GO:0045628)2.67806889
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67429155
114regulation of postsynaptic membrane potential (GO:0060078)2.66827104
115response to peptidoglycan (GO:0032494)2.66810666
116regulation of neurotransmitter secretion (GO:0046928)2.63728860
117dopamine receptor signaling pathway (GO:0007212)2.63457402
118mating behavior (GO:0007617)2.62833309
119positive regulation of neurotransmitter transport (GO:0051590)2.61976480
120negative thymic T cell selection (GO:0045060)2.61299854
121negative regulation of leukocyte mediated immunity (GO:0002704)2.60393720
122positive regulation of CREB transcription factor activity (GO:0032793)2.59860934
123activation of JUN kinase activity (GO:0007257)2.57936890
124positive T cell selection (GO:0043368)2.57715192
125alanine transport (GO:0032328)2.56746957
126regulation of early endosome to late endosome transport (GO:2000641)2.56428935
127positive regulation of protein dephosphorylation (GO:0035307)2.55728855
128membrane depolarization during action potential (GO:0086010)2.55293288
129negative regulation of cell size (GO:0045792)2.53678266
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.53206201
131innervation (GO:0060384)2.52996004
132response to auditory stimulus (GO:0010996)2.52811570
133protein localization to endosome (GO:0036010)2.51989553
134B cell receptor signaling pathway (GO:0050853)2.51880929
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51554448
136regulation of B cell receptor signaling pathway (GO:0050855)2.51545718
137social behavior (GO:0035176)2.50772447
138intraspecies interaction between organisms (GO:0051703)2.50772447
139adherens junction assembly (GO:0034333)2.50746829
140positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50252291
141regulation of mast cell degranulation (GO:0043304)2.49330683
142regulation of neurotransmitter transport (GO:0051588)2.47972737
143activation of Rac GTPase activity (GO:0032863)2.46510518
144transmission of nerve impulse (GO:0019226)2.46288424
145membrane hyperpolarization (GO:0060081)2.45994056
146regulation of translational termination (GO:0006449)2.45648400
147organelle transport along microtubule (GO:0072384)2.45557726
148regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45495991
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45448142
150long-term synaptic potentiation (GO:0060291)2.44991536
151negative T cell selection (GO:0043383)2.44312532
152negative regulation of type 2 immune response (GO:0002829)2.43764020
153peptidyl-lysine dimethylation (GO:0018027)2.42135225
154regulation of synapse maturation (GO:0090128)2.41414317
155histone H4 deacetylation (GO:0070933)2.36672474
156regulation of amyloid precursor protein catabolic process (GO:1902991)2.36481899
157regulation of beta-amyloid formation (GO:1902003)2.33403479
158positive regulation of cellular amide metabolic process (GO:0034250)2.33274907
159semaphorin-plexin signaling pathway (GO:0071526)2.29353372
160positive regulation of protein deacetylation (GO:0090312)2.29144687
161neutrophil activation involved in immune response (GO:0002283)2.29086808
162negative regulation of myotube differentiation (GO:0010832)2.28784348
163negative regulation of toll-like receptor signaling pathway (GO:0034122)2.25585261
164detection of external biotic stimulus (GO:0098581)2.24814744
165negative regulation of T cell mediated immunity (GO:0002710)2.24716299
166response to type I interferon (GO:0034340)2.22630711
167positive regulation of Rac GTPase activity (GO:0032855)2.20853502
168negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.20096439
169regulation of mast cell activation involved in immune response (GO:0033006)2.19808748
170positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18921808
171actin filament polymerization (GO:0030041)2.18452245
172type I interferon signaling pathway (GO:0060337)2.16801033
173cellular response to type I interferon (GO:0071357)2.16801033
174positive regulation of receptor recycling (GO:0001921)2.16613683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.49989966
2EZH2_22144423_ChIP-Seq_EOC_Human3.26369972
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.90003217
4VDR_21846776_ChIP-Seq_THP-1_Human2.68354267
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.53617577
6DROSHA_22980978_ChIP-Seq_HELA_Human2.52601806
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50497647
8* KDM2B_26808549_Chip-Seq_K562_Human2.36961635
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.25921563
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25468664
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22379267
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22379267
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22035326
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17735798
15* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.17528065
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08327522
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07753211
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05793046
19* KDM2B_26808549_Chip-Seq_DND41_Human2.04205619
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03918597
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03826629
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01589512
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98424939
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.98401803
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95118506
26* LXR_22292898_ChIP-Seq_THP-1_Human1.94905349
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92102390
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.91703931
29REST_21632747_ChIP-Seq_MESCs_Mouse1.91498212
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91291129
31* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90990501
32VDR_24763502_ChIP-Seq_THP-1_Human1.86895272
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.83203378
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79653602
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79535750
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.78601321
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77762196
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.77459956
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.73131651
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72291006
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72028136
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69141292
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68852215
44* KDM2B_26808549_Chip-Seq_JURKAT_Human1.68434236
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66945786
46SCL_19346495_ChIP-Seq_HPC-7_Human1.65092089
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64843714
48MAF_26560356_Chip-Seq_TH1_Human1.63646378
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62845274
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61514728
51* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60661555
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58515990
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58423818
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57309386
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.56118861
56* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53486989
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.50954089
58* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50899607
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49791874
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.49327348
61MAF_26560356_Chip-Seq_TH2_Human1.49243719
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.48387805
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48211293
64* UTX_26944678_Chip-Seq_JUKART_Human1.45904881
65SPI1_23127762_ChIP-Seq_K562_Human1.45758051
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45695046
67ZNF263_19887448_ChIP-Seq_K562_Human1.45168725
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42896228
69TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42466330
70CREB1_26743006_Chip-Seq_LNCaP_Human1.42038967
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41534176
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40857626
73RACK7_27058665_Chip-Seq_MCF-7_Human1.39316620
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38214829
75MYC_22102868_ChIP-Seq_BL_Human1.38203924
76SMC4_20622854_ChIP-Seq_HELA_Human1.34524682
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.33727923
78TCF7_22412390_ChIP-Seq_EML_Mouse1.33535713
79BCOR_27268052_Chip-Seq_Bcells_Human1.33293672
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33004172
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32880026
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.32291119
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30375012
84CTCF_27219007_Chip-Seq_Bcells_Human1.28845303
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28789934
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.28309298
87* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26179637
88BCL6_27268052_Chip-Seq_Bcells_Human1.24080073
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.23667292
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23613491
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23252257
92* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22944335
93* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21798828
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.20896499
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19118692
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18258262
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17498700
98RUNX_20019798_ChIP-Seq_JUKART_Human1.16616676
99* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16264300
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15385244
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12850563
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11628008
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10122422
104P68_20966046_ChIP-Seq_HELA_Human1.09831310
105* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07762884
106AR_21572438_ChIP-Seq_LNCaP_Human1.07357472
107* AR_19668381_ChIP-Seq_PC3_Human1.06947547
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05471117
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03326772
110TP53_22127205_ChIP-Seq_IMR90_Human1.03320696
111KLF4_19829295_ChIP-Seq_ESCs_Human1.03056365
112SA1_27219007_Chip-Seq_Bcells_Human1.02676395
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.02355589
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.02336307
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02240993
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.01061043
117* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00772359
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00486550
119* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00249192
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.00217725
121OCT4_19829295_ChIP-Seq_ESCs_Human0.99177049
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.98970362
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98484879
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98072399
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97465353
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96733861
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96590674
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.95389200
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95073557
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94647584
131* ELF1_20517297_ChIP-Seq_JURKAT_Human0.93301852
132* TP63_22573176_ChIP-Seq_HFKS_Human0.89254266
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87603227
134ATF3_27146783_Chip-Seq_COLON_Human0.87354701
135GATA1_19941826_ChIP-Seq_K562_Human0.85485554
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85202199
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85171411
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.84631462
139SMAD4_21741376_ChIP-Seq_ESCs_Human0.84129242
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82787316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.78061152
2MP0003635_abnormal_synaptic_transmissio3.69600120
3MP0003172_abnormal_lysosome_physiology3.09470742
4MP0002822_catalepsy2.94540113
5MP0003436_decreased_susceptibility_to2.91915883
6MP0003303_peritoneal_inflammation2.90547337
7MP0004270_analgesia2.84900323
8MP0003880_abnormal_central_pattern2.83930507
9MP0002063_abnormal_learning/memory/cond2.79138041
10MP0003705_abnormal_hypodermis_morpholog2.73294501
11MP0009745_abnormal_behavioral_response2.68402810
12MP0003283_abnormal_digestive_organ2.65486720
13MP0002064_seizures2.57637315
14MP0005623_abnormal_meninges_morphology2.51754661
15MP0009046_muscle_twitch2.47323651
16MP0009780_abnormal_chondrocyte_physiolo2.38162383
17MP0004858_abnormal_nervous_system2.31171858
18MP0005423_abnormal_somatic_nervous2.28014687
19MP0008260_abnormal_autophagy2.19020126
20MP0009278_abnormal_bone_marrow2.17451838
21MP0002572_abnormal_emotion/affect_behav2.07788763
22MP0002909_abnormal_adrenal_gland2.07169850
23MP0001968_abnormal_touch/_nociception2.06085529
24MP0010234_abnormal_vibrissa_follicle2.05052365
25MP0008961_abnormal_basal_metabolism2.04432681
26MP0003724_increased_susceptibility_to2.03764604
27MP0005058_abnormal_lysosome_morphology1.96350207
28MP0001486_abnormal_startle_reflex1.91607366
29MP0008569_lethality_at_weaning1.91319664
30MP0003763_abnormal_thymus_physiology1.90064239
31MP0002272_abnormal_nervous_system1.87172271
32MP0004811_abnormal_neuron_physiology1.82039026
33MP0003329_amyloid_beta_deposits1.81840282
34MP0004510_myositis1.81555433
35MP0004381_abnormal_hair_follicle1.78462212
36MP0002734_abnormal_mechanical_nocicepti1.76178576
37MP0001835_abnormal_antigen_presentation1.75841170
38MP0003183_abnormal_peptide_metabolism1.75603135
39MP0002419_abnormal_innate_immunity1.74382005
40MP0005025_abnormal_response_to1.73239234
41MP0005000_abnormal_immune_tolerance1.72763935
42MP0004885_abnormal_endolymph1.71661493
43MP0004947_skin_inflammation1.70143885
44MP0001800_abnormal_humoral_immune1.69792213
45MP0000013_abnormal_adipose_tissue1.67392844
46MP0005387_immune_system_phenotype1.65380346
47MP0001790_abnormal_immune_system1.65380346
48MP0000751_myopathy1.63216881
49MP0000685_abnormal_immune_system1.63034531
50MP0001501_abnormal_sleep_pattern1.60119649
51MP0001440_abnormal_grooming_behavior1.54499122
52MP0003191_abnormal_cellular_cholesterol1.54288881
53MP0002733_abnormal_thermal_nociception1.53571001
54MP0004130_abnormal_muscle_cell1.53528342
55MP0000955_abnormal_spinal_cord1.50454961
56MP0002420_abnormal_adaptive_immunity1.49528840
57MP0000920_abnormal_myelination1.49154795
58MP0001819_abnormal_immune_cell1.47952309
59MP0002723_abnormal_immune_serum1.45120818
60MP0004233_abnormal_muscle_weight1.43336050
61MP0001970_abnormal_pain_threshold1.41519204
62MP0005409_darkened_coat_color1.39752613
63MP0002736_abnormal_nociception_after1.37208451
64MP0002452_abnormal_antigen_presenting1.34697369
65MP0002184_abnormal_innervation1.34416759
66MP0001533_abnormal_skeleton_physiology1.34230778
67MP0003045_fibrosis1.34076950
68MP0005671_abnormal_response_to1.29319288
69MP0006082_CNS_inflammation1.28534166
70MP0001348_abnormal_lacrimal_gland1.26668855
71MP0002067_abnormal_sensory_capabilities1.26535065
72MP0003122_maternal_imprinting1.26099527
73MP0005451_abnormal_body_composition1.25551183
74MP0002557_abnormal_social/conspecific_i1.24655313
75MP0000003_abnormal_adipose_tissue1.24564619
76MP0003866_abnormal_defecation1.21430543
77MP0002066_abnormal_motor_capabilities/c1.19057898
78MP0002882_abnormal_neuron_morphology1.18022571
79MP0002249_abnormal_larynx_morphology1.17963550
80MP0002398_abnormal_bone_marrow1.16147573
81MP0003633_abnormal_nervous_system1.15749455
82MP0003879_abnormal_hair_cell1.15172234
83MP0002998_abnormal_bone_remodeling1.14624246
84MP0002933_joint_inflammation1.14175150
85MP0005464_abnormal_platelet_physiology1.13108356
86MP0000716_abnormal_immune_system1.12527724
87MP0010155_abnormal_intestine_physiology1.10919501
88MP0003787_abnormal_imprinting1.10724692
89MP0002653_abnormal_ependyma_morphology1.10674908
90MP0005386_behavior/neurological_phenoty1.09416949
91MP0004924_abnormal_behavior1.09416949
92MP0003453_abnormal_keratinocyte_physiol1.09408887
93MP0002152_abnormal_brain_morphology1.09154827
94MP0005076_abnormal_cell_differentiation1.08552716
95MP0005166_decreased_susceptibility_to1.07973317
96MP0000604_amyloidosis1.06588211
97MP0003075_altered_response_to1.05669667
98MP0002089_abnormal_postnatal_growth/wei1.05542800
99MP0000778_abnormal_nervous_system1.05504678
100MP0005167_abnormal_blood-brain_barrier1.04075057
101MP0001299_abnormal_eye_distance/1.02472039
102MP0002396_abnormal_hematopoietic_system1.02435909
103MP0005310_abnormal_salivary_gland1.01517247
104MP0003091_abnormal_cell_migration1.01015217
105MP0000747_muscle_weakness1.00549297
106MP0002234_abnormal_pharynx_morphology1.00360907
107MP0003123_paternal_imprinting1.00178380
108MP0005666_abnormal_adipose_tissue1.00057541
109MP0008874_decreased_physiological_sensi0.98452882
110MP0001851_eye_inflammation0.97438431
111MP0002405_respiratory_system_inflammati0.97276159
112MP0010352_gastrointestinal_tract_polyps0.95687708
113MP0004145_abnormal_muscle_electrophysio0.94709312
114MP0002148_abnormal_hypersensitivity_rea0.93733428
115MP0001177_atelectasis0.93669429
116MP0003631_nervous_system_phenotype0.93336415
117MP0009333_abnormal_splenocyte_physiolog0.92708044
118MP0000703_abnormal_thymus_morphology0.91759170
119MP0001873_stomach_inflammation0.90938683
120MP0001849_ear_inflammation0.88641498
121MP0005535_abnormal_body_temperature0.88342487
122MP0001545_abnormal_hematopoietic_system0.87666693
123MP0005397_hematopoietic_system_phenotyp0.87666693
124MP0001986_abnormal_taste_sensitivity0.87461999
125MP0009785_altered_susceptibility_to0.87067796
126MP0003634_abnormal_glial_cell0.84417253
127MP0000569_abnormal_digit_pigmentation0.83848619
128MP0000534_abnormal_ureter_morphology0.81575030
129MP0008872_abnormal_physiological_respon0.81443871
130MP0002429_abnormal_blood_cell0.81110120
131MP0003566_abnormal_cell_adhesion0.80563762
132MP0008770_decreased_survivor_rate0.80149765
133MP0004185_abnormal_adipocyte_glucose0.79666241
134MP0003828_pulmonary_edema0.79375753
135MP0002877_abnormal_melanocyte_morpholog0.79331303
136MP0005670_abnormal_white_adipose0.79241910
137MP0003861_abnormal_nervous_system0.77929146
138MP0001958_emphysema0.76180867
139MP0002069_abnormal_eating/drinking_beha0.75692170
140MP0005275_abnormal_skin_tensile0.75525094
141MP0002735_abnormal_chemical_nociception0.75515124
142MP0001502_abnormal_circadian_rhythm0.74964136
143MP0002722_abnormal_immune_system0.74424524
144MP0005499_abnormal_olfactory_system0.73001792
145MP0005394_taste/olfaction_phenotype0.73001792
146MP0004142_abnormal_muscle_tone0.72924621
147MP0010030_abnormal_orbit_morphology0.72495991
148MP0000537_abnormal_urethra_morphology0.68980491
149MP0003279_aneurysm0.68527344
150MP0003632_abnormal_nervous_system0.68053054
151MP0005646_abnormal_pituitary_gland0.67881037
152MP0004087_abnormal_muscle_fiber0.66419324
153MP0000759_abnormal_skeletal_muscle0.66301422
154MP0000733_abnormal_muscle_development0.66273873
155MP0001943_abnormal_respiration0.65882719
156MP0003119_abnormal_digestive_system0.65835811
157MP0010769_abnormal_survival0.64551390
158MP0003690_abnormal_glial_cell0.64527608
159MP0005375_adipose_tissue_phenotype0.64398480
160MP0003300_gastrointestinal_ulcer0.64159814
161MP0008438_abnormal_cutaneous_collagen0.64127341
162MP0002090_abnormal_vision0.63550836

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.35176395
2Myokymia (HP:0002411)4.92081457
3Focal motor seizures (HP:0011153)3.85586634
4Abnormality of the lower motor neuron (HP:0002366)3.77805959
5Focal seizures (HP:0007359)3.76649692
6Eczematoid dermatitis (HP:0000976)3.63251212
7Visual hallucinations (HP:0002367)3.57443280
8Diplopia (HP:0000651)3.42310135
9Abnormality of binocular vision (HP:0011514)3.42310135
10Insomnia (HP:0100785)3.21911928
11Action tremor (HP:0002345)3.17967511
12Distal upper limb amyotrophy (HP:0007149)3.12619312
13Upper limb amyotrophy (HP:0009129)3.12619312
14Annular pancreas (HP:0001734)3.02553126
15Cerebral aneurysm (HP:0004944)3.01812257
16Hyperacusis (HP:0010780)2.97605408
17Broad face (HP:0000283)2.94408414
18Ankle clonus (HP:0011448)2.93210172
19Neurofibrillary tangles (HP:0002185)2.87415204
20Hemiplegia (HP:0002301)2.84265230
21Pointed chin (HP:0000307)2.76596310
22Supranuclear gaze palsy (HP:0000605)2.73111328
23Ankyloglossia (HP:0010296)2.72573699
24Depression (HP:0000716)2.71412674
25Cellulitis (HP:0100658)2.68976962
26Protrusio acetabuli (HP:0003179)2.68178163
27Increased IgE level (HP:0003212)2.65188595
28Achilles tendon contracture (HP:0001771)2.61466509
29Neuronal loss in central nervous system (HP:0002529)2.56091455
30Recurrent bacterial skin infections (HP:0005406)2.52976224
31Abnormality of the fingertips (HP:0001211)2.52814007
32Dysmetric saccades (HP:0000641)2.52735879
33Resting tremor (HP:0002322)2.52027080
34Hand muscle atrophy (HP:0009130)2.51817243
35Myositis (HP:0100614)2.50552806
36Shallow orbits (HP:0000586)2.47667205
37Atonic seizures (HP:0010819)2.46869727
38Recurrent abscess formation (HP:0002722)2.45725974
39Neoplasm of the heart (HP:0100544)2.43883314
40Slow saccadic eye movements (HP:0000514)2.43548968
41Impaired social interactions (HP:0000735)2.41205402
42Abnormal social behavior (HP:0012433)2.41205402
43Colitis (HP:0002583)2.40438654
44Peripheral hypomyelination (HP:0007182)2.38204902
45Abnormality of oral frenula (HP:0000190)2.38089311
46Bowel diverticulosis (HP:0005222)2.36753811
47Gastrointestinal inflammation (HP:0004386)2.36424590
48Lower limb amyotrophy (HP:0007210)2.35890408
49Dysdiadochokinesis (HP:0002075)2.35090348
50Absence seizures (HP:0002121)2.34602549
51Impaired vibration sensation in the lower limbs (HP:0002166)2.33938666
52Abnormality of macrophages (HP:0004311)2.33784035
53Generalized tonic-clonic seizures (HP:0002069)2.33098669
54Abnormality of the Achilles tendon (HP:0005109)2.31867446
55Urinary bladder sphincter dysfunction (HP:0002839)2.31641669
56Poor eye contact (HP:0000817)2.31072958
57Macroorchidism (HP:0000053)2.30168590
58Easy fatigability (HP:0003388)2.26767859
59Postural instability (HP:0002172)2.26148898
60Ventricular fibrillation (HP:0001663)2.23856217
61Megalencephaly (HP:0001355)2.23605498
62Gingivitis (HP:0000230)2.23206624
63Stridor (HP:0010307)2.22692812
64Bladder diverticulum (HP:0000015)2.21515141
65Inflammation of the large intestine (HP:0002037)2.20633438
66Urinary urgency (HP:0000012)2.19310074
67Bronchomalacia (HP:0002780)2.19248934
68Papilledema (HP:0001085)2.18358969
69Turricephaly (HP:0000262)2.17470741
70Epileptic encephalopathy (HP:0200134)2.17241642
71Progressive cerebellar ataxia (HP:0002073)2.16850206
72Meningitis (HP:0001287)2.16732024
73Dysostosis multiplex (HP:0000943)2.16485078
74Elfin facies (HP:0004428)2.15578862
75Genu recurvatum (HP:0002816)2.15131034
76J-shaped sella turcica (HP:0002680)2.14884679
77Pustule (HP:0200039)2.14426827
78Chronic obstructive pulmonary disease (HP:0006510)2.13941723
79Obstructive lung disease (HP:0006536)2.13941723
80Recurrent fungal infections (HP:0002841)2.13450156
81Renal duplication (HP:0000075)2.13156205
82Torticollis (HP:0000473)2.13102797
83Gastrointestinal infarctions (HP:0005244)2.11208975
84Dialeptic seizures (HP:0011146)2.11113690
85Spinal canal stenosis (HP:0003416)2.10864921
86Orchitis (HP:0100796)2.10130007
87Hypercortisolism (HP:0001578)2.10008037
88Mediastinal lymphadenopathy (HP:0100721)2.09250050
89Dilatation of the ascending aorta (HP:0005111)2.07799798
90Increased cerebral lipofuscin (HP:0011813)2.07159383
91Genetic anticipation (HP:0003743)2.06912956
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05341588
93Spontaneous hematomas (HP:0007420)2.04839074
94Prolonged bleeding time (HP:0003010)2.04804346
95Febrile seizures (HP:0002373)2.02938157
96Increased connective tissue (HP:0009025)2.02733666
97Bundle branch block (HP:0011710)2.02587806
98Premature rupture of membranes (HP:0001788)2.02358882
99Polygenic inheritance (HP:0010982)2.01651946
100Impaired smooth pursuit (HP:0007772)2.00910874
101Sleep apnea (HP:0010535)2.00400316
102Thin bony cortex (HP:0002753)2.00300434
103Overriding aorta (HP:0002623)2.00165444
104Increased variability in muscle fiber diameter (HP:0003557)1.99290548
105Metaphyseal cupping (HP:0003021)1.99110844
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.98844490
107Aplasia involving bones of the upper limbs (HP:0009823)1.98486755
108Aplasia of the phalanges of the hand (HP:0009802)1.98486755
109Aplasia involving bones of the extremities (HP:0009825)1.98486755
110Agammaglobulinemia (HP:0004432)1.97515994
111Hypoventilation (HP:0002791)1.97430670
112Dysmetria (HP:0001310)1.96339295
113Exercise-induced myalgia (HP:0003738)1.95981484
114Difficulty running (HP:0009046)1.95779594
115Renovascular hypertension (HP:0100817)1.94740455
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.94730531
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91200725
118Rapidly progressive (HP:0003678)1.90627287
119Truncal ataxia (HP:0002078)1.90610133
120Onion bulb formation (HP:0003383)1.89203903
121Mitral valve prolapse (HP:0001634)1.89156787
122Intention tremor (HP:0002080)1.88241734
123Muscle fiber splitting (HP:0003555)1.87874604
124Optic neuritis (HP:0100653)1.87795909
125Retrobulbar optic neuritis (HP:0100654)1.87795909
126Gastrointestinal stroma tumor (HP:0100723)1.86376977
127Recurrent skin infections (HP:0001581)1.85397960
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.84485674
129Insidious onset (HP:0003587)1.83712297
130Termporal pattern (HP:0011008)1.83712297
131Bowel incontinence (HP:0002607)1.83519263
132Flat cornea (HP:0007720)1.83315694
133Distal lower limb muscle weakness (HP:0009053)1.82220358
134Myopathic facies (HP:0002058)1.81884822
135Difficulty climbing stairs (HP:0003551)1.80911840
136Elevated erythrocyte sedimentation rate (HP:0003565)1.80502868
137Chronic mucocutaneous candidiasis (HP:0002728)1.80349595
138Recurrent cutaneous fungal infections (HP:0011370)1.80349595
139Stereotypic behavior (HP:0000733)1.80234564
140Chest pain (HP:0100749)1.79335153
141Bradykinesia (HP:0002067)1.78804921
142Hypochromic anemia (HP:0001931)1.78608271
143Rigidity (HP:0002063)1.78599518
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78140516
145Abnormality of polysaccharide metabolism (HP:0011012)1.78140516
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78140516
147Focal dystonia (HP:0004373)1.77810172
148Distal lower limb amyotrophy (HP:0008944)1.77595830
149Recurrent gram-negative bacterial infections (HP:0005420)1.77544206
150Enlarged penis (HP:0000040)1.77370744
151Abnormality of the astrocytes (HP:0100707)1.76731720
152Astrocytoma (HP:0009592)1.76731720
153Atrophic scars (HP:0001075)1.76722677
154Ocular albinism (HP:0001107)1.76494087
155Abnormality of ocular smooth pursuit (HP:0000617)1.76395116
156Mucopolysacchariduria (HP:0008155)1.75598450
157Urinary glycosaminoglycan excretion (HP:0003541)1.75598450
158Hemiparesis (HP:0001269)1.75343185
159Anxiety (HP:0000739)1.74996400
160Hyporeflexia of lower limbs (HP:0002600)1.74144444
161Spastic gait (HP:0002064)1.73769162
162Amblyopia (HP:0000646)1.71458694
163Axonal loss (HP:0003447)1.71219640
164Tetraplegia (HP:0002445)1.70456930
165Apathy (HP:0000741)1.70227722
166Panhypogammaglobulinemia (HP:0003139)1.69754554
167Deep palmar crease (HP:0006191)1.69074043
168Clonus (HP:0002169)1.69017986
169Emphysema (HP:0002097)1.68884148
170Hemorrhage of the eye (HP:0011885)1.68637987
171Deviation of the hallux (HP:0010051)1.68140060
172Hallux valgus (HP:0001822)1.68031122
173Status epilepticus (HP:0002133)1.67638484
174Cerebral inclusion bodies (HP:0100314)1.66872352
175Abnormal eating behavior (HP:0100738)1.66519021
176Broad metatarsal (HP:0001783)1.65769298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.50337063
2TRIB33.33838351
3PRKD33.07164735
4EPHA42.98955321
5NTRK32.95501133
6MAP4K12.54026130
7PAK62.53878592
8TYRO32.50655305
9PKN22.35310088
10KSR22.34763750
11CAMKK12.15056127
12MINK12.04104079
13RIPK11.95535918
14PDGFRA1.88359369
15LATS21.88082509
16EEF2K1.84944270
17DAPK21.84433181
18TAOK11.82068446
19DDR21.77809728
20STK381.76720281
21NTRK11.76673434
22MAP3K41.74733080
23MAP2K31.72248973
24ALK1.70790503
25ICK1.58713958
26NTRK21.56642508
27TYK21.50699306
28SIK21.45866550
29SMG11.42624867
30BLK1.31724434
31ZAP701.30158430
32PRKCH1.28419581
33MAP2K41.27617229
34MAPK121.25213250
35EPHB11.23692224
36UHMK11.22016776
37RET1.21716869
38TTN1.21633854
39IRAK41.19744384
40CDK51.19276755
41FGFR41.17788288
42KSR11.16837394
43MAP3K21.15715301
44PRPF4B1.14970279
45NEK11.11436876
46PRKD21.11340690
47MAP3K71.09917319
48GRK61.09033613
49CDK121.06787845
50CDC42BPA1.04062700
51LMTK21.02523672
52STK111.02406726
53CSK1.01360533
54BTK1.00853813
55MARK11.00433379
56JAK11.00348972
57MAP3K101.00278303
58TBK10.96262158
59SIK30.96184454
60HIPK20.92087241
61HCK0.90633856
62PAK30.90070136
63DAPK10.89926254
64MAP3K60.89563398
65MARK20.88507907
66CDK150.86817071
67SCYL20.86203930
68WNK10.85708304
69MAP3K30.85685945
70MAP2K60.85187979
71JAK30.84432197
72DMPK0.84000926
73CDK180.80775436
74CAMK1G0.80158087
75PTK60.80028672
76MAPK70.79736726
77MAP3K130.79488842
78IKBKE0.79243526
79PTK20.78170715
80SYK0.78105825
81FES0.78100782
82CDK11A0.77077426
83IRAK20.76648255
84CDK140.74551752
85IRAK30.73882399
86GRK50.73809133
87PHKG20.73108607
88PHKG10.73108607
89CAMK10.72231416
90MAP3K10.71866313
91MAP3K140.68942651
92JAK20.67705969
93SIK10.67263110
94PDGFRB0.65456582
95MTOR0.63331722
96PDPK10.63007007
97PRKCG0.62476376
98FER0.62392219
99ITK0.62283476
100ERN10.62116565
101SGK30.61602105
102RPS6KC10.60831207
103RPS6KL10.60831207
104SGK2230.60532359
105SGK4940.60532359
106PTK2B0.60340178
107NEK60.60320592
108PAK20.59229477
109CSF1R0.59099693
110PDK10.58636585
111SGK20.56721508
112BRSK10.56589226
113MAP3K110.56122099
114PRKD10.55958603
115FGR0.55542374
116FGFR30.54750432
117RAF10.54472009
118LRRK20.52365635
119RPS6KA30.52305629
120FGFR10.52253700
121MAPK100.51955525
122MAP2K10.51817837
123PINK10.51428480
124LCK0.50484599
125* FYN0.48624274
126RPS6KA60.48055241
127* TNK20.47908993
128KIT0.47633126
129DYRK1B0.47148280
130SGK10.46406646
131RIPK40.46344014
132TAOK20.44956585
133CAMK40.44588372
134ROCK10.44131384
135CDK190.40334032
136RPS6KA20.39143578
137CAMK1D0.38927294
138MAP2K70.38863930
139MOS0.38213097
140FGFR20.37919037
141ARAF0.37085511
142CSNK1E0.36514682
143MAPK80.35990609
144ROCK20.35599068
145PNCK0.34627448

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.36174084
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31338323
3Olfactory transduction_Homo sapiens_hsa047402.25513539
4Nitrogen metabolism_Homo sapiens_hsa009102.17493001
5Long-term potentiation_Homo sapiens_hsa047202.14199678
6Nicotine addiction_Homo sapiens_hsa050332.06955093
7GABAergic synapse_Homo sapiens_hsa047272.00387425
8Circadian entrainment_Homo sapiens_hsa047131.95747590
9Glutamatergic synapse_Homo sapiens_hsa047241.84152616
10Salivary secretion_Homo sapiens_hsa049701.81440810
11Gastric acid secretion_Homo sapiens_hsa049711.78990220
12Amphetamine addiction_Homo sapiens_hsa050311.77782595
13B cell receptor signaling pathway_Homo sapiens_hsa046621.73469776
14Morphine addiction_Homo sapiens_hsa050321.70647682
15Osteoclast differentiation_Homo sapiens_hsa043801.66867321
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66305620
17Dopaminergic synapse_Homo sapiens_hsa047281.65029557
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64157982
19Notch signaling pathway_Homo sapiens_hsa043301.64131210
20Other glycan degradation_Homo sapiens_hsa005111.63593749
21Insulin secretion_Homo sapiens_hsa049111.61951021
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61651295
23Glioma_Homo sapiens_hsa052141.59347495
24Acute myeloid leukemia_Homo sapiens_hsa052211.58285308
25GnRH signaling pathway_Homo sapiens_hsa049121.56943735
26Oxytocin signaling pathway_Homo sapiens_hsa049211.55730664
27Cholinergic synapse_Homo sapiens_hsa047251.54759018
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51124539
29Gap junction_Homo sapiens_hsa045401.44868549
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43882649
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40026868
32Estrogen signaling pathway_Homo sapiens_hsa049151.38683193
33Cocaine addiction_Homo sapiens_hsa050301.34017627
34Leishmaniasis_Homo sapiens_hsa051401.31153476
35mTOR signaling pathway_Homo sapiens_hsa041501.29434735
36Renin secretion_Homo sapiens_hsa049241.27169120
37Long-term depression_Homo sapiens_hsa047301.27131355
38ErbB signaling pathway_Homo sapiens_hsa040121.25337701
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24172689
40Dorso-ventral axis formation_Homo sapiens_hsa043201.23278792
41T cell receptor signaling pathway_Homo sapiens_hsa046601.22334485
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21695127
43Type II diabetes mellitus_Homo sapiens_hsa049301.16680626
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16187281
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14791251
46VEGF signaling pathway_Homo sapiens_hsa043701.14672989
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.11299668
48cAMP signaling pathway_Homo sapiens_hsa040241.10369639
49Calcium signaling pathway_Homo sapiens_hsa040201.10342205
50Tuberculosis_Homo sapiens_hsa051521.09905320
51Non-small cell lung cancer_Homo sapiens_hsa052231.08449847
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08121192
53Melanogenesis_Homo sapiens_hsa049161.07381013
54Chemokine signaling pathway_Homo sapiens_hsa040621.06132839
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05558144
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03735975
57Endometrial cancer_Homo sapiens_hsa052131.02410689
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.01068044
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99984285
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99048407
61Taste transduction_Homo sapiens_hsa047420.97989459
62Dilated cardiomyopathy_Homo sapiens_hsa054140.96454966
63Axon guidance_Homo sapiens_hsa043600.95504659
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.94390643
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94199423
66Toxoplasmosis_Homo sapiens_hsa051450.90931246
67Oocyte meiosis_Homo sapiens_hsa041140.90704519
68Bladder cancer_Homo sapiens_hsa052190.90373386
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.89252172
70Chronic myeloid leukemia_Homo sapiens_hsa052200.88788269
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88682505
72Proteoglycans in cancer_Homo sapiens_hsa052050.88547501
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.88008662
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87813985
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87730404
76Choline metabolism in cancer_Homo sapiens_hsa052310.87334385
77Rap1 signaling pathway_Homo sapiens_hsa040150.85763057
78Pancreatic cancer_Homo sapiens_hsa052120.84384045
79MAPK signaling pathway_Homo sapiens_hsa040100.84315634
80Hepatitis C_Homo sapiens_hsa051600.84026288
81Focal adhesion_Homo sapiens_hsa045100.83514416
82TNF signaling pathway_Homo sapiens_hsa046680.82682879
83Influenza A_Homo sapiens_hsa051640.82525663
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81691845
85Thyroid hormone synthesis_Homo sapiens_hsa049180.80944632
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80763901
87Insulin signaling pathway_Homo sapiens_hsa049100.80489202
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.80447577
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78113241
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77882375
91Staphylococcus aureus infection_Homo sapiens_hsa051500.77421123
92Endocytosis_Homo sapiens_hsa041440.77271918
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76943939
94Serotonergic synapse_Homo sapiens_hsa047260.76570062
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75912331
96Renal cell carcinoma_Homo sapiens_hsa052110.75086938
97Hippo signaling pathway_Homo sapiens_hsa043900.74746787
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.74301134
99Fatty acid biosynthesis_Homo sapiens_hsa000610.74192753
100Bile secretion_Homo sapiens_hsa049760.74024216
101Primary immunodeficiency_Homo sapiens_hsa053400.73636968
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.73222307
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71855840
104Glucagon signaling pathway_Homo sapiens_hsa049220.70014707
105Hepatitis B_Homo sapiens_hsa051610.68556548
106Measles_Homo sapiens_hsa051620.68259013
107Graft-versus-host disease_Homo sapiens_hsa053320.67916751
108Allograft rejection_Homo sapiens_hsa053300.67230444
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67148876
110Pancreatic secretion_Homo sapiens_hsa049720.66187606
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65802440
112Malaria_Homo sapiens_hsa051440.65651531
113Insulin resistance_Homo sapiens_hsa049310.65633593
114Tight junction_Homo sapiens_hsa045300.65610523
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65153242
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.64341616
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63738136
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.63047727
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62563217
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61673336
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61421961
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61139646
123Hedgehog signaling pathway_Homo sapiens_hsa043400.60475578
124Wnt signaling pathway_Homo sapiens_hsa043100.59739556
125Platelet activation_Homo sapiens_hsa046110.59004948
126Ras signaling pathway_Homo sapiens_hsa040140.58701472
127Colorectal cancer_Homo sapiens_hsa052100.58146625
128Inositol phosphate metabolism_Homo sapiens_hsa005620.57871324
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57000974
130Prolactin signaling pathway_Homo sapiens_hsa049170.56982926
131Amoebiasis_Homo sapiens_hsa051460.53361791
132Prion diseases_Homo sapiens_hsa050200.53176843
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52634352
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.51230591
135Adherens junction_Homo sapiens_hsa045200.51189048
136AMPK signaling pathway_Homo sapiens_hsa041520.50437958

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