TNMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)9.43508712
2protein heterotrimerization (GO:0070208)9.27449030
3keratan sulfate catabolic process (GO:0042340)9.00910685
4triglyceride catabolic process (GO:0019433)8.40642511
5collagen fibril organization (GO:0030199)8.39856921
6acylglycerol catabolic process (GO:0046464)7.39948599
7neutral lipid catabolic process (GO:0046461)7.39948599
8bone trabecula formation (GO:0060346)7.24983210
9sequestering of extracellular ligand from receptor (GO:0035581)6.35420798
10response to dietary excess (GO:0002021)6.29852279
11skin morphogenesis (GO:0043589)6.19163317
12regulation of sequestering of triglyceride (GO:0010889)6.17737125
13chondrocyte proliferation (GO:0035988)5.89942703
14extracellular matrix assembly (GO:0085029)5.82782868
15transcytosis (GO:0045056)5.54904207
16glycerolipid catabolic process (GO:0046503)5.36235406
17collagen metabolic process (GO:0032963)5.30080809
18glomerular filtration (GO:0003094)5.29511684
19collagen catabolic process (GO:0030574)5.22089900
20endodermal cell differentiation (GO:0035987)5.21602276
21fatty acid homeostasis (GO:0055089)5.12369703
22positive regulation of glomerulus development (GO:0090193)4.99459848
23multicellular organismal macromolecule metabolic process (GO:0044259)4.96025414
24extracellular fibril organization (GO:0043206)4.95338857
25chondrocyte development (GO:0002063)4.93215094
26multicellular organismal catabolic process (GO:0044243)4.79421830
27ovulation from ovarian follicle (GO:0001542)4.69256398
28multicellular organismal metabolic process (GO:0044236)4.67277354
29planar cell polarity pathway involved in neural tube closure (GO:0090179)4.67242380
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.66473986
31regulation of gonadotropin secretion (GO:0032276)4.60161359
32renal filtration (GO:0097205)4.58734070
33negative regulation of macrophage differentiation (GO:0045650)4.54267346
34negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.52310467
35fibril organization (GO:0097435)4.50500270
36myoblast migration (GO:0051451)4.50447410
37lipid particle organization (GO:0034389)4.48814517
38regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.40814055
39white fat cell differentiation (GO:0050872)4.38294099
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.37952828
41diacylglycerol metabolic process (GO:0046339)4.37804689
42NADH metabolic process (GO:0006734)4.36862505
43epithelial cell-cell adhesion (GO:0090136)4.35975003
44brown fat cell differentiation (GO:0050873)4.33144027
45negative regulation of amino acid transport (GO:0051956)4.30048971
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.29166077
47extracellular matrix disassembly (GO:0022617)4.26289085
48regulation of cAMP-dependent protein kinase activity (GO:2000479)4.25427147
49positive regulation of cellular response to insulin stimulus (GO:1900078)4.23182199
50negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.18889939
51positive regulation of insulin receptor signaling pathway (GO:0046628)4.15511619
52lipid storage (GO:0019915)4.10611646
53peptidyl-proline hydroxylation (GO:0019511)4.07884338
54polyol transport (GO:0015791)4.06804521
55craniofacial suture morphogenesis (GO:0097094)4.00952088
56negative regulation of chondrocyte differentiation (GO:0032331)3.99429716
57regulation of glycogen (starch) synthase activity (GO:2000465)3.97659974
58tyrosine phosphorylation of STAT protein (GO:0007260)3.97632512
59cGMP-mediated signaling (GO:0019934)3.96813966
60negative regulation of granulocyte differentiation (GO:0030853)3.96035470
61cell adhesion mediated by integrin (GO:0033627)3.95962925
62plasma lipoprotein particle clearance (GO:0034381)3.93083089
63negative regulation of response to food (GO:0032096)3.91772705
64negative regulation of appetite (GO:0032099)3.91772705
65dermatan sulfate biosynthetic process (GO:0030208)3.91732390
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.90879493
67axon extension involved in axon guidance (GO:0048846)3.90879493
68cellular response to epinephrine stimulus (GO:0071872)3.90480354
69keratan sulfate biosynthetic process (GO:0018146)3.83253631
70positive regulation of catenin import into nucleus (GO:0035413)3.80253934
71negative regulation of smooth muscle cell migration (GO:0014912)3.78408292
72protein localization to cell surface (GO:0034394)3.78266091
73paraxial mesoderm development (GO:0048339)3.77386803
74adhesion of symbiont to host cell (GO:0044650)3.76360085
75virion attachment to host cell (GO:0019062)3.76360085
76negative regulation of cell fate specification (GO:0009996)3.73429638
77endocrine hormone secretion (GO:0060986)3.73077605
78embryonic cranial skeleton morphogenesis (GO:0048701)3.73022340
79negative regulation of JUN kinase activity (GO:0043508)3.67490490
80non-canonical Wnt signaling pathway (GO:0035567)3.63958945
81negative regulation of embryonic development (GO:0045992)3.62193719
82extracellular matrix organization (GO:0030198)3.61717864
83regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.60902364
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.60837642
85cellular response to leptin stimulus (GO:0044320)3.60679403
86extracellular structure organization (GO:0043062)3.60297821
87positive regulation of endothelial cell apoptotic process (GO:2000353)3.59999249
88regulation of lipoprotein metabolic process (GO:0050746)3.58710402
89regulation of cholesterol storage (GO:0010885)3.58441571
90adult feeding behavior (GO:0008343)3.57042525
91dermatan sulfate metabolic process (GO:0030205)3.56668010
92extracellular negative regulation of signal transduction (GO:1900116)3.53983701
93extracellular regulation of signal transduction (GO:1900115)3.53983701
94skeletal muscle adaptation (GO:0043501)3.52887753
95negative regulation of DNA biosynthetic process (GO:2000279)3.52783266
96protein trimerization (GO:0070206)3.52630825
97peripheral nervous system axon ensheathment (GO:0032292)3.52061350
98myelination in peripheral nervous system (GO:0022011)3.52061350
99muscle cell migration (GO:0014812)3.49187896
100cellular response to vitamin (GO:0071295)3.48160275
101CDP-diacylglycerol biosynthetic process (GO:0016024)3.46425044
102camera-type eye morphogenesis (GO:0048593)3.46052157
103cellular response to vitamin D (GO:0071305)3.45620645
104triglyceride biosynthetic process (GO:0019432)3.44970920
105response to vitamin E (GO:0033197)3.44503110
106regulation of cardiac muscle cell apoptotic process (GO:0010665)3.43402824
107peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.38879016
108glycerol metabolic process (GO:0006071)3.38447395
109keratan sulfate metabolic process (GO:0042339)3.38363884
110cranial suture morphogenesis (GO:0060363)3.38116340
111cornea development in camera-type eye (GO:0061303)3.36124867
112triglyceride metabolic process (GO:0006641)3.36115463
113convergent extension (GO:0060026)3.35923873
114bone morphogenesis (GO:0060349)3.35458967
115regulation of non-canonical Wnt signaling pathway (GO:2000050)3.34940894
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31391365
117positive regulation of glucose import (GO:0046326)3.31273874
118kidney mesenchyme development (GO:0072074)3.30328818
119phagocytosis, recognition (GO:0006910)3.29367332
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.29304647
121protein hydroxylation (GO:0018126)3.28577153
122middle ear morphogenesis (GO:0042474)3.26909680
123retinol metabolic process (GO:0042572)3.26351521
124neutral lipid biosynthetic process (GO:0046460)3.24864610
125acylglycerol biosynthetic process (GO:0046463)3.24864610
126response to epinephrine (GO:0071871)3.24395319
127regulation of glomerulus development (GO:0090192)3.23497741
128negative regulation of cartilage development (GO:0061037)3.23347958
129glycosaminoglycan catabolic process (GO:0006027)3.22628684
130regulation of plasminogen activation (GO:0010755)3.21875508
131CDP-diacylglycerol metabolic process (GO:0046341)3.20986721
132regulation of extracellular matrix disassembly (GO:0010715)3.20433689
133cellular response to amino acid stimulus (GO:0071230)3.20307196
134primary alcohol metabolic process (GO:0034308)3.20241045
135regulation of establishment of planar polarity (GO:0090175)3.19469509
136wound healing, spreading of epidermal cells (GO:0035313)3.18802946
137metanephric mesenchyme development (GO:0072075)3.18480288
138prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.17524742
139retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17064978
140regulation of catenin import into nucleus (GO:0035412)3.14926805
141negative regulation of gluconeogenesis (GO:0045721)3.13516662
142substrate-dependent cell migration (GO:0006929)3.13068539
143response to leptin (GO:0044321)3.12210960
144blood vessel maturation (GO:0001955)3.10671634
145mesenchymal-epithelial cell signaling (GO:0060638)3.09346208
146response to phenylpropanoid (GO:0080184)3.08078990
147negative regulation of fatty acid transport (GO:2000192)3.07986426
148epoxygenase P450 pathway (GO:0019373)3.07648760
149negative regulation of BMP signaling pathway (GO:0030514)3.06797041
150negative regulation of phagocytosis (GO:0050765)3.05774112
151regulation of striated muscle cell apoptotic process (GO:0010662)3.05472121
152negative regulation of norepinephrine secretion (GO:0010700)3.04775233
153positive regulation of metanephros development (GO:0072216)3.04752946
154acylglycerol metabolic process (GO:0006639)3.04726441
155response to nitrosative stress (GO:0051409)3.04651869
156negative regulation of metanephros development (GO:0072217)3.04235526
157negative regulation of striated muscle cell apoptotic process (GO:0010664)3.03549088
158sulfur compound catabolic process (GO:0044273)3.03126723
159positive regulation of extracellular matrix organization (GO:1903055)3.02624364
160outer ear morphogenesis (GO:0042473)3.02466741
161glomerular basement membrane development (GO:0032836)3.02003803
162biotin metabolic process (GO:0006768)3.00206300
163neutral lipid metabolic process (GO:0006638)3.00175397
164positive regulation of cholesterol efflux (GO:0010875)3.00155889
165ossification (GO:0001503)2.99960314
166positive regulation of lipid storage (GO:0010884)2.99101376
167negative regulation of smooth muscle cell proliferation (GO:0048662)2.97384523
168aminoglycan catabolic process (GO:0006026)2.97374198
169basement membrane organization (GO:0071711)2.96034628
170positive regulation of epithelial to mesenchymal transition (GO:0010718)2.95842945
171negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.95819106
172negative regulation of organic acid transport (GO:0032891)2.94837344
173cellular response to lithium ion (GO:0071285)2.94331996
174ethanol oxidation (GO:0006069)2.92749998
175alditol metabolic process (GO:0019400)2.92744190
176fatty acid transmembrane transport (GO:1902001)2.92524253
177regulation of macrophage derived foam cell differentiation (GO:0010743)2.91565463
178tooth mineralization (GO:0034505)2.91368767
179adhesion of symbiont to host (GO:0044406)2.91197913
180negative regulation of catenin import into nucleus (GO:0035414)2.91045682
181negative regulation of protein autophosphorylation (GO:0031953)2.90429115
182cell migration involved in heart development (GO:0060973)2.89538080
183oxaloacetate metabolic process (GO:0006107)2.88372953
184negative regulation of stress fiber assembly (GO:0051497)2.86701384
185positive regulation of glycolytic process (GO:0045821)2.82048881
186regulation of gastrulation (GO:0010470)2.78950550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.78694207
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.65059941
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.16342591
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.75410651
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.06754716
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01720520
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.01056191
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.97360825
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.80043950
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70761315
11CJUN_26792858_Chip-Seq_BT549_Human2.64489071
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.63703771
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.62643236
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56061137
15CLOCK_20551151_ChIP-Seq_293T_Human2.39496874
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29822966
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29822966
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23400626
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.21262463
20NRF2_20460467_ChIP-Seq_MEFs_Mouse2.21262463
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.18836481
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.18289446
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16484299
24PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.15153734
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12620188
26BRD4_25478319_ChIP-Seq_HGPS_Human2.10306496
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06028011
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05457010
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04780502
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04344641
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04306280
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.1582742
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97494086
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97494086
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97494086
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96634640
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92906585
38PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.91336022
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.87281631
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76831692
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76306222
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.75964191
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.70471051
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69314814
45TP53_18474530_ChIP-ChIP_U2OS_Human1.66259254
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63674487
47EZH2_22144423_ChIP-Seq_EOC_Human1.63657150
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62863502
49AR_21572438_ChIP-Seq_LNCaP_Human1.61186371
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.60254321
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.57817091
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57403720
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.53131016
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53012861
55SMC1_22415368_ChIP-Seq_MEFs_Mouse1.51588913
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51381995
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.50035461
58TP53_16413492_ChIP-PET_HCT116_Human1.49439446
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46830780
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46171830
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45343741
62IGF1R_20145208_ChIP-Seq_DFB_Human1.45039327
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.38716336
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37819575
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35543911
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.34803005
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32430891
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30569037
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26345267
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26308033
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25098463
72DROSHA_22980978_ChIP-Seq_HELA_Human1.23857879
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.22752927
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21232977
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18057088
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17938923
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17392827
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17317481
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.17233754
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16277025
81SA1_22415368_ChIP-Seq_MEFs_Mouse1.16258425
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15634696
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15473728
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14846095
85CBP_21632823_ChIP-Seq_H3396_Human1.14735269
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14632766
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.14328633
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14207109
89GBX2_23144817_ChIP-Seq_PC3_Human1.13491598
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11698371
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10196702
92SOX2_20726797_ChIP-Seq_SW620_Human1.09977498
93FUS_26573619_Chip-Seq_HEK293_Human1.07281826
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05110171
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02047119
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.00292478
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.00203606
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99838923
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99768950
100ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99215788
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98688620
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.97254931
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.96941884
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.96941884
105SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96540072
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96198501
107P300_19829295_ChIP-Seq_ESCs_Human0.94786178
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94096133
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94096133
110EOMES_21245162_ChIP-Seq_HESCs_Human0.92964752
111TP53_23651856_ChIP-Seq_MEFs_Mouse0.92955864
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.92264325
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91817223
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91673209
115EGR1_19032775_ChIP-ChIP_M12_Human0.90772156
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90636737
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90592539
118ZNF263_19887448_ChIP-Seq_K562_Human0.90547581
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89592316
120BCAT_22108803_ChIP-Seq_LS180_Human0.89458038
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89080740
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88706263
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.88100136
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86759280
125KDM2B_26808549_Chip-Seq_REH_Human0.86286705
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.85681306
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85231619
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.83875650
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83698164
130NFI_21473784_ChIP-Seq_ESCs_Mouse0.83183711
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82244610
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82208789
133KLF5_25053715_ChIP-Seq_YYC3_Human0.81226740
134TP63_23658742_ChIP-Seq_EP156T_Human0.81107844
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80530398
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79948718
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79773580
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79312950
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77557193
140* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76948161
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76519812
142NANOG_16518401_ChIP-PET_MESCs_Mouse0.74599463
143TCF4_22108803_ChIP-Seq_LS180_Human0.73950758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.08081830
2* MP0005503_abnormal_tendon_morphology7.66195461
3MP0005275_abnormal_skin_tensile7.16500385
4MP0005670_abnormal_white_adipose6.77812874
5MP0005666_abnormal_adipose_tissue4.64114150
6MP0005257_abnormal_intraocular_pressure4.53929388
7MP0004130_abnormal_muscle_cell3.70880523
8MP0005375_adipose_tissue_phenotype3.62617183
9MP0003279_aneurysm3.56704418
10MP0003705_abnormal_hypodermis_morpholog3.37161732
11MP0004185_abnormal_adipocyte_glucose3.21302513
12MP0001958_emphysema3.19210582
13MP0002971_abnormal_brown_adipose3.09656364
14MP0006054_spinal_hemorrhage2.91960769
15* MP0005508_abnormal_skeleton_morphology2.63932796
16MP0009115_abnormal_fat_cell2.58097547
17MP0009384_cardiac_valve_regurgitation2.51447742
18* MP0002108_abnormal_muscle_morphology2.49111639
19MP0002876_abnormal_thyroid_physiology2.33439290
20MP0004272_abnormal_basement_membrane2.32214938
21MP0001542_abnormal_bone_strength2.14779301
22MP0002060_abnormal_skin_morphology2.08911512
23MP0003011_delayed_dark_adaptation2.02062411
24MP0003959_abnormal_lean_body2.01676345
25MP0006138_congestive_heart_failure1.99406221
26MP0005379_endocrine/exocrine_gland_phen1.93461092
27MP0002295_abnormal_pulmonary_circulatio1.92632779
28MP0010329_abnormal_lipoprotein_level1.87118602
29MP0003186_abnormal_redox_activity1.83089205
30MP0002970_abnormal_white_adipose1.82197512
31MP0009250_abnormal_appendicular_skeleto1.80599936
32MP0002896_abnormal_bone_mineralization1.73455170
33MP0005334_abnormal_fat_pad1.67664124
34MP0003385_abnormal_body_wall1.60388865
35MP0004215_abnormal_myocardial_fiber1.56263155
36MP0005623_abnormal_meninges_morphology1.56211691
37MP0002933_joint_inflammation1.55353858
38* MP0005390_skeleton_phenotype1.53303343
39MP0003950_abnormal_plasma_membrane1.51674208
40MP0005023_abnormal_wound_healing1.51615458
41MP0004134_abnormal_chest_morphology1.50297582
42MP0003828_pulmonary_edema1.44558081
43MP0000751_myopathy1.43009063
44MP0001243_abnormal_dermal_layer1.42480438
45MP0003566_abnormal_cell_adhesion1.40506527
46MP0005385_cardiovascular_system_phenoty1.37275482
47MP0001544_abnormal_cardiovascular_syste1.37275482
48MP0005535_abnormal_body_temperature1.36544023
49MP0000163_abnormal_cartilage_morphology1.35967994
50MP0001299_abnormal_eye_distance/1.32985999
51MP0002115_abnormal_skeleton_extremities1.27920199
52MP0010030_abnormal_orbit_morphology1.27266417
53MP0005448_abnormal_energy_balance1.25407824
54MP0000013_abnormal_adipose_tissue1.20978044
55MP0002282_abnormal_trachea_morphology1.17688523
56MP0003690_abnormal_glial_cell1.16153914
57MP0001661_extended_life_span1.13827626
58MP0005620_abnormal_muscle_contractility1.12711240
59MP0002998_abnormal_bone_remodeling1.12285221
60MP0004084_abnormal_cardiac_muscle1.12269822
61MP0002932_abnormal_joint_morphology1.12107381
62MP0002837_dystrophic_cardiac_calcinosis1.12017890
63MP0000733_abnormal_muscle_development1.10615439
64MP0003091_abnormal_cell_migration1.08962148
65MP0005452_abnormal_adipose_tissue1.08497869
66MP0001533_abnormal_skeleton_physiology1.06940705
67MP0010352_gastrointestinal_tract_polyps1.06761359
68MP0002118_abnormal_lipid_homeostasis1.05896593
69MP0002113_abnormal_skeleton_development1.04389402
70MP0001348_abnormal_lacrimal_gland1.04093973
71MP0006276_abnormal_autonomic_nervous1.02516169
72MP0000428_abnormal_craniofacial_morphol1.02244777
73MP0003941_abnormal_skin_development1.01624513
74MP0002638_abnormal_pupillary_reflex0.98539706
75MP0000767_abnormal_smooth_muscle0.97216520
76MP0001879_abnormal_lymphatic_vessel0.95348569
77MP0003868_abnormal_feces_composition0.95093385
78MP0002909_abnormal_adrenal_gland0.92053534
79MP0002089_abnormal_postnatal_growth/wei0.91508389
80MP0003283_abnormal_digestive_organ0.91279678
81MP0002109_abnormal_limb_morphology0.90880544
82MP0010630_abnormal_cardiac_muscle0.90211225
83MP0000049_abnormal_middle_ear0.89628598
84MP0003115_abnormal_respiratory_system0.87907710
85MP0009053_abnormal_anal_canal0.87426671
86MP0003755_abnormal_palate_morphology0.86450730
87* MP0005369_muscle_phenotype0.85893689
88MP0005076_abnormal_cell_differentiation0.85745061
89MP0002168_other_aberrant_phenotype0.84529841
90MP0002972_abnormal_cardiac_muscle0.83949709
91MP0003795_abnormal_bone_structure0.83827195
92MP0005171_absent_coat_pigmentation0.83697741
93MP0006036_abnormal_mitochondrial_physio0.83356320
94MP0005197_abnormal_uvea_morphology0.82010451
95MP0002249_abnormal_larynx_morphology0.78002274
96MP0002106_abnormal_muscle_physiology0.78001562
97MP0002233_abnormal_nose_morphology0.76956304
98MP0000534_abnormal_ureter_morphology0.76490986
99MP0005388_respiratory_system_phenotype0.76332192
100MP0002133_abnormal_respiratory_system0.76332192
101MP0003948_abnormal_gas_homeostasis0.76119680
102MP0003724_increased_susceptibility_to0.74448676
103MP0003567_abnormal_fetal_cardiomyocyte0.73544887
104MP0001177_atelectasis0.73347854
105MP0005167_abnormal_blood-brain_barrier0.71954093
106MP0001346_abnormal_lacrimal_gland0.70675583
107MP0002116_abnormal_craniofacial_bone0.70252767
108MP0001727_abnormal_embryo_implantation0.69816629
109MP0003937_abnormal_limbs/digits/tail_de0.69713874
110MP0003942_abnormal_urinary_system0.69246712
111MP0000759_abnormal_skeletal_muscle0.68713117
112MP0005595_abnormal_vascular_smooth0.68683248
113MP0008775_abnormal_heart_ventricle0.68424893
114MP0000003_abnormal_adipose_tissue0.68319622
115MP0005330_cardiomyopathy0.68254870
116MP0004036_abnormal_muscle_relaxation0.67278960
117MP0002111_abnormal_tail_morphology0.67063158
118MP0002078_abnormal_glucose_homeostasis0.66593098
119MP0000747_muscle_weakness0.65877945
120MP0002114_abnormal_axial_skeleton0.65722002
121MP0000432_abnormal_head_morphology0.64416614
122MP0003045_fibrosis0.63608379
123MP0003137_abnormal_impulse_conducting0.62898578
124MP0000749_muscle_degeneration0.61928133
125MP0002128_abnormal_blood_circulation0.61882271
126MP0005193_abnormal_anterior_eye0.61722569
127MP0004484_altered_response_of0.61236903
128MP0002796_impaired_skin_barrier0.60102866
129MP0009672_abnormal_birth_weight0.59729759
130MP0003935_abnormal_craniofacial_develop0.59576172
131MP0005164_abnormal_response_to0.58695113
132MP0004883_abnormal_blood_vessel0.58101650
133MP0009780_abnormal_chondrocyte_physiolo0.58071124
134MP0005220_abnormal_exocrine_pancreas0.57439720
135MP0004145_abnormal_muscle_electrophysio0.56792546
136MP0005409_darkened_coat_color0.55761396
137MP0002177_abnormal_outer_ear0.55359310
138MP0003448_altered_tumor_morphology0.54999166
139MP0000462_abnormal_digestive_system0.52416544
140MP0010771_integument_phenotype0.52029464
141MP0004087_abnormal_muscle_fiber0.51584369
142MP0001614_abnormal_blood_vessel0.51399980
143MP0000762_abnormal_tongue_morphology0.50819919
144MP0003122_maternal_imprinting0.49974544
145MP0001175_abnormal_lung_morphology0.49728137
146MP0003300_gastrointestinal_ulcer0.48907071
147MP0000343_altered_response_to0.46736636
148MP0005367_renal/urinary_system_phenotyp0.46676064
149MP0000516_abnormal_urinary_system0.46676064
150MP0000750_abnormal_muscle_regeneration0.46149843
151MP0010368_abnormal_lymphatic_system0.45907375
152MP0002697_abnormal_eye_size0.45819982

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.31097287
2Oligomenorrhea (HP:0000876)6.07874849
3Ankle contracture (HP:0006466)5.44037210
4Soft skin (HP:0000977)5.41267372
5Aortic dissection (HP:0002647)5.14099159
6Type 1 muscle fiber predominance (HP:0003803)4.95575792
7Peritonitis (HP:0002586)4.90307261
8Abnormality of dentin (HP:0010299)4.88004970
9Shallow orbits (HP:0000586)4.86503766
10Biconcave vertebral bodies (HP:0004586)4.76411423
11Atrophic scars (HP:0001075)4.73036572
12Broad metatarsal (HP:0001783)4.71491991
13Follicular hyperkeratosis (HP:0007502)4.60382545
14Neonatal short-limb short stature (HP:0008921)4.43986035
15Bladder diverticulum (HP:0000015)4.33457476
16Acanthosis nigricans (HP:0000956)4.26160137
17Genu recurvatum (HP:0002816)4.16002316
18Wormian bones (HP:0002645)4.14973534
19Vertebral compression fractures (HP:0002953)4.08155608
20Aortic aneurysm (HP:0004942)3.98760463
21Slender build (HP:0001533)3.94400611
22Hypertriglyceridemia (HP:0002155)3.94347891
23Fragile skin (HP:0001030)3.88973487
24Dilatation of the ascending aorta (HP:0005111)3.88902359
25Cervical subluxation (HP:0003308)3.85994179
26Mitral valve prolapse (HP:0001634)3.72506074
27Blue sclerae (HP:0000592)3.67627880
28Spinal rigidity (HP:0003306)3.64290036
29Ulnar deviation of the wrist (HP:0003049)3.61011311
30Cerebral aneurysm (HP:0004944)3.48823619
31Wrist flexion contracture (HP:0001239)3.41184481
32Hyperextensible skin (HP:0000974)3.39088171
33Increased connective tissue (HP:0009025)3.32697855
34Abnormal delivery (HP:0001787)3.22087666
35Breech presentation (HP:0001623)3.19720217
36Flat cornea (HP:0007720)3.13072268
37Nausea (HP:0002018)3.09312296
38Trismus (HP:0000211)3.06768966
39Round ear (HP:0100830)3.05908685
40Spondylolisthesis (HP:0003302)3.05547964
41Chin dimple (HP:0010751)2.96632292
42Increased variability in muscle fiber diameter (HP:0003557)2.95181431
43Absent phalangeal crease (HP:0006109)2.93774240
44Hip contracture (HP:0003273)2.91636062
45Bowel diverticulosis (HP:0005222)2.83205281
46Metatarsus adductus (HP:0001840)2.80752613
47Abnormality of the acetabulum (HP:0003170)2.77892526
48Joint laxity (HP:0001388)2.75833836
49Wide anterior fontanel (HP:0000260)2.74863608
50Hyperlipoproteinemia (HP:0010980)2.73204469
51Infantile muscular hypotonia (HP:0008947)2.72505988
52Mildly elevated creatine phosphokinase (HP:0008180)2.72013069
53Nonimmune hydrops fetalis (HP:0001790)2.68480666
54Difficulty running (HP:0009046)2.66131706
55Broad ribs (HP:0000885)2.65163164
56Abnormality of skeletal muscle fiber size (HP:0012084)2.64919464
57Mild short stature (HP:0003502)2.64880654
58Bell-shaped thorax (HP:0001591)2.63572932
59Vascular tortuosity (HP:0004948)2.62707267
60Ectopia lentis (HP:0001083)2.62474808
61Lipoatrophy (HP:0100578)2.59789474
62Insulin resistance (HP:0000855)2.57375709
63Morphological abnormality of the middle ear (HP:0008609)2.56446757
64Elbow flexion contracture (HP:0002987)2.55393793
65Osteoarthritis (HP:0002758)2.55127706
66Prominent supraorbital ridges (HP:0000336)2.52144666
67Abnormality of the ischium (HP:0003174)2.48985831
68Overgrowth (HP:0001548)2.46707459
69Limited hip movement (HP:0008800)2.46682092
70Tibial bowing (HP:0002982)2.40749549
71Striae distensae (HP:0001065)2.39604968
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.39336761
73Osteolytic defects of the hand bones (HP:0009699)2.39336761
74Calcaneovalgus deformity (HP:0001848)2.37873055
75Decreased skull ossification (HP:0004331)2.35131714
76Femoral bowing (HP:0002980)2.34660349
77Abnormal eating behavior (HP:0100738)2.32780518
78Abnormal finger flexion creases (HP:0006143)2.30427284
79Lymphangioma (HP:0100764)2.30071958
80Skin nodule (HP:0200036)2.29832970
81Microglossia (HP:0000171)2.23866153
82Aortic regurgitation (HP:0001659)2.22991884
83Mitral regurgitation (HP:0001653)2.22638323
84Nemaline bodies (HP:0003798)2.21948037
85Fused cervical vertebrae (HP:0002949)2.21856990
86Deviation of the hallux (HP:0010051)2.19518972
87Hallux valgus (HP:0001822)2.18287720
88Myotonia (HP:0002486)2.16467127
89Coronal craniosynostosis (HP:0004440)2.15714161
90Insulin-resistant diabetes mellitus (HP:0000831)2.14910043
91Thin bony cortex (HP:0002753)2.13985165
92Deformed tarsal bones (HP:0008119)2.13141176
93Malignant hyperthermia (HP:0002047)2.12817244
94Abnormality of skull ossification (HP:0002703)2.12499308
95Delayed closure of the anterior fontanelle (HP:0001476)2.12239231
96Neck muscle weakness (HP:0000467)2.10369206
97Back pain (HP:0003418)2.08743794
98Camptodactyly of toe (HP:0001836)2.08028410
99Arterial tortuosity (HP:0005116)2.07870581
100Aneurysm (HP:0002617)2.07618192
101Asymmetry of the thorax (HP:0001555)2.04641987
102Venous insufficiency (HP:0005293)2.04221642
103Venous abnormality (HP:0002624)2.03304105
104Coxa vara (HP:0002812)2.02673372
105Osteopenia (HP:0000938)2.02241362
106Reduced subcutaneous adipose tissue (HP:0003758)2.02125131
107Myocardial infarction (HP:0001658)2.01755810
108Muscle fiber splitting (HP:0003555)2.01024125
109Gowers sign (HP:0003391)2.00796117
110Abnormality of the peritoneum (HP:0002585)2.00588619
111Protrusio acetabuli (HP:0003179)10.4587545
112Spinal cord compression (HP:0002176)1.97844862
113Delayed cranial suture closure (HP:0000270)1.96852170
114Protruding ear (HP:0000411)1.93658251
115Buphthalmos (HP:0000557)1.93507514
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93269343
117Turricephaly (HP:0000262)1.91766819
118Subcapsular cataract (HP:0000523)1.91713834
119Bone cyst (HP:0012062)1.89468352
120Platyspondyly (HP:0000926)1.88305355
121Enlarged penis (HP:0000040)1.88120071
122Delayed epiphyseal ossification (HP:0002663)1.87860029
123Hypoplastic ischia (HP:0003175)1.87674926
124Generalized amyotrophy (HP:0003700)1.87590941
125Absent frontal sinuses (HP:0002688)1.87177745
126Disproportionate tall stature (HP:0001519)1.86627208
127Increased muscle lipid content (HP:0009058)1.86287030
128Hypoventilation (HP:0002791)1.85879149
129Beaking of vertebral bodies (HP:0004568)1.84903766
130Inguinal hernia (HP:0000023)1.84431136
131Thin skin (HP:0000963)1.84343140
132Mesomelia (HP:0003027)1.83738617
133Popliteal pterygium (HP:0009756)1.82995808
134Syringomyelia (HP:0003396)1.82029828
135Spinal cord lesions (HP:0100561)1.82029828
136Broad long bones (HP:0005622)1.81311702
137Choanal stenosis (HP:0000452)1.79473049
138Limb-girdle muscle weakness (HP:0003325)1.78679812
139Distal arthrogryposis (HP:0005684)1.78225854
140Abnormality of the calcaneus (HP:0008364)1.76225358
141Knee flexion contracture (HP:0006380)1.75937669
142Sprengel anomaly (HP:0000912)1.75421462
143Epidermoid cyst (HP:0200040)1.73683766
144Hypophosphatemic rickets (HP:0004912)1.72043151
145Pigmentary retinal degeneration (HP:0001146)1.71518399
146Aplasia of the musculature (HP:0100854)1.69611155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.65976120
2SIK14.08802575
3PDGFRA3.65118884
4TIE13.64495841
5LATS23.58034687
6EPHA33.55550079
7TRIB33.51246008
8TTN3.17828554
9LATS12.95651088
10ERN12.78391761
11CAMK12.31629415
12EPHB22.29171219
13STK38L2.11017505
14NLK2.05203521
15RIPK12.05131462
16PRKAA21.98558288
17PAK21.87702369
18PAK31.69486957
19PKN21.66038270
20PIK3CA1.65618740
21PTK2B1.62173814
22FER1.61441487
23MKNK21.57748453
24TGFBR21.53321248
25OBSCN1.52545782
26PLK21.50949391
27PIK3CG1.45631418
28DMPK1.41178253
29PTK21.36878577
30MKNK11.34968194
31NTRK11.32504163
32GRK51.30715638
33TNIK1.28668975
34FGFR21.28260400
35NEK91.28214858
36STK161.27077510
37EPHB11.27017782
38ROCK11.17730364
39MET1.17120191
40LRRK21.15098999
41MYLK1.14300871
42FRK1.13024425
43PDPK11.12862605
44YES11.12123722
45JAK11.11910298
46FGFR11.11710670
47EPHA41.10710699
48PDGFRB1.10302411
49GRK11.08615060
50CDK91.08413289
51TGFBR11.07977792
52MAPK41.07541193
53ARAF1.06861464
54TRPM71.05623789
55LIMK11.03910605
56STK31.02686385
57EEF2K1.02403759
58ROCK21.02122071
59BMX0.97313792
60PTK60.95386109
61KSR20.91864279
62SCYL20.91767940
63CAMK1D0.90499236
64MAPKAPK30.89598230
65TESK10.87068010
66PRKG10.86371757
67PINK10.86102926
68ADRBK10.85783649
69STK240.85728060
70ERBB30.82589591
71PAK40.80810613
72MTOR0.74991398
73ILK0.74516860
74PRKCH0.71000844
75PIM20.70130556
76INSR0.69499603
77TTK0.69424392
78MOS0.68785121
79MAPKAPK50.68401310
80ERBB40.67016484
81NME10.66474304
82CDC42BPA0.65903676
83KIT0.65625837
84MAPK70.65429076
85PRKD10.64400735
86FGFR40.63592272
87DYRK1B0.63025648
88FLT30.62728476
89MST1R0.62646423
90PDK10.61694009
91RET0.61366063
92CLK10.59586870
93PRKD30.57716400
94PRKAA10.57437393
95CSF1R0.57104716
96PRKACG0.56143513
97PRKD20.55035260
98CDK40.54612155
99MAP2K10.54225073
100DYRK20.53616618
101BRAF0.53071782
102PRKACB0.51981935
103MAP3K130.51629581
104CAMK1G0.50568158
105FGFR30.50208813
106MAP3K30.49105895
107SRC0.48332495
108RPS6KA40.47947689
109ABL20.47801201
110PRKCE0.45924161
111PBK0.44649481
112CDK30.44210249
113PHKG10.43286764
114PHKG20.43286764
115GSK3A0.42676385
116BMPR1B0.42513656
117DAPK30.40490243
118KDR0.40238135
119PAK60.39401766
120EIF2AK30.39377021
121CDC70.38271512
122PRKACA0.37450427
123VRK20.36657070
124LMTK20.34023506
125ABL10.33019111
126CSK0.31832547
127EIF2AK20.31315052
128AKT20.31155477
129RPS6KA30.30990847
130CDK80.30914502
131MARK20.29405282
132FYN0.28620251
133MAP3K70.28617159
134CDK60.28185040
135ERBB20.27397558
136MAP2K30.26856324
137CAMKK10.25532523
138PRKCG0.25427599
139MAPK10.24890590
140MAPK120.24752266
141PAK10.22393427
142PRKG20.22365069
143CDK140.22122528
144CHUK0.22055682
145IGF1R0.21404404
146PKN10.20373399
147MAP3K60.20314936
148JAK20.19861076
149TAOK20.19379104
150CAMKK20.17856519
151TAOK10.17200308

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.61931919
2PPAR signaling pathway_Homo sapiens_hsa033204.23986880
3Protein digestion and absorption_Homo sapiens_hsa049743.67470915
4Focal adhesion_Homo sapiens_hsa045103.49746389
5Malaria_Homo sapiens_hsa051443.32822899
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04255558
7Phenylalanine metabolism_Homo sapiens_hsa003602.92886601
8Glycerolipid metabolism_Homo sapiens_hsa005612.73485005
9Fatty acid elongation_Homo sapiens_hsa000622.70191153
10Pyruvate metabolism_Homo sapiens_hsa006202.68897587
11Fatty acid degradation_Homo sapiens_hsa000712.53141675
12Propanoate metabolism_Homo sapiens_hsa006402.51172590
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47950066
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.35003074
15Amoebiasis_Homo sapiens_hsa051462.33076694
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31490532
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.30603818
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27895330
19Dilated cardiomyopathy_Homo sapiens_hsa054142.26448810
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15924988
21Fatty acid biosynthesis_Homo sapiens_hsa000612.12778977
22Proteoglycans in cancer_Homo sapiens_hsa052052.11737972
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11267252
24Fatty acid metabolism_Homo sapiens_hsa012121.97006346
25beta-Alanine metabolism_Homo sapiens_hsa004101.96138023
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91729207
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.88556712
28TGF-beta signaling pathway_Homo sapiens_hsa043501.82000236
29Adherens junction_Homo sapiens_hsa045201.79000388
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72662798
31Tyrosine metabolism_Homo sapiens_hsa003501.68696115
32Histidine metabolism_Homo sapiens_hsa003401.67033185
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65752314
34AMPK signaling pathway_Homo sapiens_hsa041521.63720738
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62029277
36MicroRNAs in cancer_Homo sapiens_hsa052061.52834614
37Bladder cancer_Homo sapiens_hsa052191.52803467
38Fat digestion and absorption_Homo sapiens_hsa049751.47739963
39Hippo signaling pathway_Homo sapiens_hsa043901.46969517
40Basal cell carcinoma_Homo sapiens_hsa052171.46420417
41Wnt signaling pathway_Homo sapiens_hsa043101.42202992
42Tryptophan metabolism_Homo sapiens_hsa003801.40740160
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32437721
44Melanoma_Homo sapiens_hsa052181.31901725
45Phagosome_Homo sapiens_hsa041451.28373798
46Renin secretion_Homo sapiens_hsa049241.27580549
47Prion diseases_Homo sapiens_hsa050201.25181025
48Hedgehog signaling pathway_Homo sapiens_hsa043401.21574897
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18915565
50Platelet activation_Homo sapiens_hsa046111.15501421
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13285822
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10154819
53Small cell lung cancer_Homo sapiens_hsa052221.09482951
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07558365
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.03487771
56Axon guidance_Homo sapiens_hsa043601.00177753
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00016535
58Rap1 signaling pathway_Homo sapiens_hsa040150.97849974
59Thyroid hormone synthesis_Homo sapiens_hsa049180.95215023
60Estrogen signaling pathway_Homo sapiens_hsa049150.93637656
61Glioma_Homo sapiens_hsa052140.93397767
62Melanogenesis_Homo sapiens_hsa049160.92298371
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90867819
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90211791
65Glutathione metabolism_Homo sapiens_hsa004800.89933692
66Chronic myeloid leukemia_Homo sapiens_hsa052200.89337861
67Pathways in cancer_Homo sapiens_hsa052000.88093858
68TNF signaling pathway_Homo sapiens_hsa046680.86282584
69Prostate cancer_Homo sapiens_hsa052150.85090377
70Steroid biosynthesis_Homo sapiens_hsa001000.83685377
71Toxoplasmosis_Homo sapiens_hsa051450.83630792
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83021570
73Retinol metabolism_Homo sapiens_hsa008300.81922145
74Parkinsons disease_Homo sapiens_hsa050120.81524937
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81109618
76Carbon metabolism_Homo sapiens_hsa012000.79517517
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79156478
78GnRH signaling pathway_Homo sapiens_hsa049120.78514622
79Proteasome_Homo sapiens_hsa030500.78040526
80Pancreatic cancer_Homo sapiens_hsa052120.77624146
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77284929
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77247346
83Viral myocarditis_Homo sapiens_hsa054160.76362430
84Gap junction_Homo sapiens_hsa045400.73867180
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.73543419
86Osteoclast differentiation_Homo sapiens_hsa043800.73091522
87Cardiac muscle contraction_Homo sapiens_hsa042600.72145727
88Shigellosis_Homo sapiens_hsa051310.72055934
89Vitamin digestion and absorption_Homo sapiens_hsa049770.71977933
90Insulin resistance_Homo sapiens_hsa049310.71132332
91Complement and coagulation cascades_Homo sapiens_hsa046100.70783545
92Rheumatoid arthritis_Homo sapiens_hsa053230.70551321
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68543590
94p53 signaling pathway_Homo sapiens_hsa041150.68244678
95Oxidative phosphorylation_Homo sapiens_hsa001900.67038455
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66966985
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63617795
98Tight junction_Homo sapiens_hsa045300.63152129
99Alzheimers disease_Homo sapiens_hsa050100.62920590
100Renin-angiotensin system_Homo sapiens_hsa046140.62871392
101RNA polymerase_Homo sapiens_hsa030200.62828879
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.62505093
103HTLV-I infection_Homo sapiens_hsa051660.61295372
104Renal cell carcinoma_Homo sapiens_hsa052110.59893050
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.59671813
106Ras signaling pathway_Homo sapiens_hsa040140.59253576
107MAPK signaling pathway_Homo sapiens_hsa040100.58741919
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.58539326
109FoxO signaling pathway_Homo sapiens_hsa040680.58295809
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.58209384
111Glucagon signaling pathway_Homo sapiens_hsa049220.56856013
112Colorectal cancer_Homo sapiens_hsa052100.56340252
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55393803
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55227858
115Vibrio cholerae infection_Homo sapiens_hsa051100.54918378
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53488862
117Oxytocin signaling pathway_Homo sapiens_hsa049210.52741943
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50873814
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49353501
120cAMP signaling pathway_Homo sapiens_hsa040240.48976184
121Lysine degradation_Homo sapiens_hsa003100.48640718
122Cocaine addiction_Homo sapiens_hsa050300.48509198
123Leishmaniasis_Homo sapiens_hsa051400.48142047
124mTOR signaling pathway_Homo sapiens_hsa041500.48114034
125HIF-1 signaling pathway_Homo sapiens_hsa040660.47398049
126Hepatitis B_Homo sapiens_hsa051610.47123018
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.46378416
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.45971202
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45809583
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45567897
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44719583
132Endocytosis_Homo sapiens_hsa041440.42659362
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42568610
134Thyroid cancer_Homo sapiens_hsa052160.41780579
135Huntingtons disease_Homo sapiens_hsa050160.41765022
136Amphetamine addiction_Homo sapiens_hsa050310.41753969
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.41406389
138Peroxisome_Homo sapiens_hsa041460.41172461
139Ovarian steroidogenesis_Homo sapiens_hsa049130.40878801
140Lysosome_Homo sapiens_hsa041420.40582973
141Arginine and proline metabolism_Homo sapiens_hsa003300.40200574
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39624176
143Nitrogen metabolism_Homo sapiens_hsa009100.39577961
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39418718
145Vitamin B6 metabolism_Homo sapiens_hsa007500.39046830
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38668432
147Type II diabetes mellitus_Homo sapiens_hsa049300.38383008
148Insulin signaling pathway_Homo sapiens_hsa049100.38196285
149Gastric acid secretion_Homo sapiens_hsa049710.37648646
150Pertussis_Homo sapiens_hsa051330.37350242
151Chemical carcinogenesis_Homo sapiens_hsa052040.37049808
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.36879652
153Salmonella infection_Homo sapiens_hsa051320.36823882
154Endometrial cancer_Homo sapiens_hsa052130.35633979
155Bile secretion_Homo sapiens_hsa049760.33726561
156Butanoate metabolism_Homo sapiens_hsa006500.31745958
157Ribosome_Homo sapiens_hsa030100.28468643
158Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25978240
159Folate biosynthesis_Homo sapiens_hsa007900.20814930
160Biosynthesis of amino acids_Homo sapiens_hsa012300.18947445

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