TNN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diol metabolic process (GO:0034311)9.55156521
2cellular response to vitamin D (GO:0071305)9.23309488
3sphingoid metabolic process (GO:0046519)8.75398641
4biomineral tissue development (GO:0031214)8.69768795
5cellular response to vitamin (GO:0071295)8.10740201
6protein heterotrimerization (GO:0070208)7.99690936
7bone trabecula formation (GO:0060346)7.34078649
8collagen fibril organization (GO:0030199)7.28800960
9collagen catabolic process (GO:0030574)5.92908183
10odontogenesis of dentin-containing tooth (GO:0042475)5.90663341
11endodermal cell differentiation (GO:0035987)5.86511890
12response to gravity (GO:0009629)5.85441457
13notochord development (GO:0030903)5.84070704
14collagen metabolic process (GO:0032963)5.82706225
15odontogenesis (GO:0042476)5.60407736
16glomerular basement membrane development (GO:0032836)5.48276228
17hemidesmosome assembly (GO:0031581)5.47505241
18multicellular organismal macromolecule metabolic process (GO:0044259)5.46544449
19positive regulation of odontogenesis (GO:0042482)5.46348821
20multicellular organismal catabolic process (GO:0044243)5.45991195
21mesenchymal-epithelial cell signaling (GO:0060638)5.44250175
22cornea development in camera-type eye (GO:0061303)5.42487099
23skin morphogenesis (GO:0043589)5.41369873
24replacement ossification (GO:0036075)5.30254301
25endochondral ossification (GO:0001958)5.30254301
26response to vitamin D (GO:0033280)5.25601042
27extracellular matrix disassembly (GO:0022617)5.24087194
28multicellular organismal metabolic process (GO:0044236)5.16610141
29negative regulation of glycoprotein biosynthetic process (GO:0010561)5.13523155
30chondrocyte development (GO:0002063)5.07700945
31protein-chromophore linkage (GO:0018298)4.91036260
32regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.87993169
33paraxial mesoderm development (GO:0048339)4.87937244
34peptidyl-proline hydroxylation (GO:0019511)4.84870674
35regulation of odontogenesis (GO:0042481)4.83766521
36regulation of biomineral tissue development (GO:0070167)4.65715124
37negative regulation of cytosolic calcium ion concentration (GO:0051481)4.64189710
38chondrocyte proliferation (GO:0035988)4.49587318
39regulation of protein glycosylation (GO:0060049)4.38274475
40adhesion of symbiont to host cell (GO:0044650)4.36662342
41virion attachment to host cell (GO:0019062)4.36662342
42negative regulation of glycoprotein metabolic process (GO:1903019)4.29970180
43DNA methylation involved in gamete generation (GO:0043046)4.27340409
44glomerular filtration (GO:0003094)4.26700258
45piRNA metabolic process (GO:0034587)4.25480729
46cellular response to nutrient (GO:0031670)4.22803857
47cell migration involved in heart development (GO:0060973)4.13696047
48keratan sulfate catabolic process (GO:0042340)4.11752997
49osteoblast differentiation (GO:0001649)4.08779729
50negative regulation of biomineral tissue development (GO:0070168)4.03651920
51cell adhesion mediated by integrin (GO:0033627)4.02853545
52protein hydroxylation (GO:0018126)3.99192501
53osteoblast development (GO:0002076)3.91892209
54sequestering of extracellular ligand from receptor (GO:0035581)3.90601603
55low-density lipoprotein particle clearance (GO:0034383)3.87753229
56planar cell polarity pathway involved in neural tube closure (GO:0090179)3.82086057
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.81731772
58axon extension involved in axon guidance (GO:0048846)3.81731772
59renal filtration (GO:0097205)3.74509526
60response to phenylpropanoid (GO:0080184)3.72356053
61regulation of pigment cell differentiation (GO:0050932)3.69589682
62craniofacial suture morphogenesis (GO:0097094)3.69510340
63bone morphogenesis (GO:0060349)3.69385625
64keratan sulfate biosynthetic process (GO:0018146)3.67949640
65bone mineralization (GO:0030282)3.67118018
66ossification (GO:0001503)3.66403647
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.65348183
68regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.64740839
69regulation of sequestering of triglyceride (GO:0010889)3.64298438
70lipopolysaccharide biosynthetic process (GO:0009103)3.59836930
71substrate-dependent cell migration (GO:0006929)3.58520927
72regulation of extracellular matrix disassembly (GO:0010715)3.57097314
73extracellular matrix organization (GO:0030198)3.56927004
74adhesion of symbiont to host (GO:0044406)3.56687645
75regulation of bone remodeling (GO:0046850)3.56289488
76extracellular structure organization (GO:0043062)3.55535310
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.55096966
78positive regulation of collagen biosynthetic process (GO:0032967)3.53505006
79sulfate transmembrane transport (GO:1902358)3.49407397
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.45015369
81cranial suture morphogenesis (GO:0060363)3.44330252
82extracellular matrix assembly (GO:0085029)3.43330119
83regulation of collagen metabolic process (GO:0010712)3.39773628
84regulation of bone mineralization (GO:0030500)3.39225653
85mesenchyme morphogenesis (GO:0072132)3.36434190
86positive regulation of collagen metabolic process (GO:0010714)3.34030998
87cellular response to amino acid stimulus (GO:0071230)3.33644952
88negative regulation of embryonic development (GO:0045992)3.30838173
89positive regulation of developmental pigmentation (GO:0048087)3.29105559
90COPI coating of Golgi vesicle (GO:0048205)3.27326069
91Golgi transport vesicle coating (GO:0048200)3.27326069
92epithelial to mesenchymal transition (GO:0001837)3.26948414
93adult feeding behavior (GO:0008343)3.26516888
94regulation of meiosis I (GO:0060631)3.25076512
95negative regulation of cell-matrix adhesion (GO:0001953)3.19530825
96embryonic cranial skeleton morphogenesis (GO:0048701)3.19500676
97triglyceride catabolic process (GO:0019433)3.16841466
98wound healing, spreading of epidermal cells (GO:0035313)3.14710698
99positive regulation of fatty acid oxidation (GO:0046321)3.13686411
100transcytosis (GO:0045056)3.12844693
101regulation of collagen biosynthetic process (GO:0032965)3.12507372
102keratan sulfate metabolic process (GO:0042339)3.08160995
103regulation of tight junction assembly (GO:2000810)3.08079523
104negative regulation of nitric oxide biosynthetic process (GO:0045019)3.07420666
105positive regulation of catenin import into nucleus (GO:0035413)3.06526740
106heart valve formation (GO:0003188)3.06259963
107regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.06202749
108negative regulation of bone mineralization (GO:0030502)3.05290470
109negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.01405708
110positive regulation of mesenchymal cell proliferation (GO:0002053)2.99117944
111extracellular fibril organization (GO:0043206)2.98281298
112regulation of metanephros development (GO:0072215)2.97822106
113opioid receptor signaling pathway (GO:0038003)2.97185465
114molting cycle (GO:0042303)2.94222591
115hair cycle (GO:0042633)2.94222591
116lipopolysaccharide metabolic process (GO:0008653)2.93983414
117dermatan sulfate biosynthetic process (GO:0030208)2.89842285
118anterior/posterior axis specification, embryo (GO:0008595)2.88802067
119regulation of translational termination (GO:0006449)2.88147591
120response to epinephrine (GO:0071871)2.87118766
121nodal signaling pathway (GO:0038092)2.86947512
122apoptotic cell clearance (GO:0043277)2.85782506
123outer ear morphogenesis (GO:0042473)2.85636471
124skeletal system development (GO:0001501)2.85151284
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.82950094
126positive regulation of glomerulus development (GO:0090193)2.82518473
127sulfate transport (GO:0008272)2.82439638
128negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.80148300
129response to mercury ion (GO:0046689)2.79139146
130maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78402388
131toxin metabolic process (GO:0009404)2.78153062
132acylglycerol catabolic process (GO:0046464)2.77335946
133neutral lipid catabolic process (GO:0046461)2.77335946
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.75941402
135positive regulation of biomineral tissue development (GO:0070169)2.75228150
136fibril organization (GO:0097435)2.73404277
137regulation of mesenchymal cell proliferation (GO:0010464)2.73316833
138vascular endothelial growth factor signaling pathway (GO:0038084)2.73276207
139convergent extension (GO:0060026)2.73201969
140regulation of transforming growth factor beta2 production (GO:0032909)2.73017614
141tyrosine metabolic process (GO:0006570)2.72562299
142axis elongation (GO:0003401)2.71803323
143regulation of multicellular organismal metabolic process (GO:0044246)2.70855367
144positive regulation of metanephros development (GO:0072216)2.70446997
145positive regulation of lipoprotein lipase activity (GO:0051006)2.69165670
146positive regulation of triglyceride lipase activity (GO:0061365)2.69165670
147negative regulation of chondrocyte differentiation (GO:0032331)2.68657559
148regulation of glomerular filtration (GO:0003093)2.67978142
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66641909
150insulin-like growth factor receptor signaling pathway (GO:0048009)2.66121668
151behavioral response to ethanol (GO:0048149)2.66080837
152cartilage development (GO:0051216)2.65861229
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.65646902
154hair follicle morphogenesis (GO:0031069)2.65188634
155cellular response to interferon-alpha (GO:0035457)2.65184375
156regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.65074383
157chondrocyte differentiation (GO:0002062)2.62422287
158trabecula formation (GO:0060343)2.62028839
159lymph vessel development (GO:0001945)2.61525751
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61151818
161germinal center formation (GO:0002467)2.59743891
162glycerol metabolic process (GO:0006071)2.57812294
163cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57715944
164cAMP biosynthetic process (GO:0006171)2.56064177
165negative regulation of cAMP-mediated signaling (GO:0043951)2.55768876
166SMAD protein complex assembly (GO:0007183)2.54481971
167negative regulation of platelet activation (GO:0010544)2.54304730
168negative regulation of cell cycle G2/M phase transition (GO:1902750)2.54162203
169phagocytosis, recognition (GO:0006910)2.54067377
170camera-type eye morphogenesis (GO:0048593)2.52395656
171negative regulation of stem cell proliferation (GO:2000647)2.50129426
172peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49557994
173endothelium development (GO:0003158)2.49550488
174erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44765571
175L-phenylalanine catabolic process (GO:0006559)2.44765571
176regulation of keratinocyte proliferation (GO:0010837)2.39826251
177positive regulation of fatty acid beta-oxidation (GO:0032000)2.38177873
178response to folic acid (GO:0051593)2.37839415
179positive regulation of cAMP-mediated signaling (GO:0043950)2.36863339
180Notch signaling involved in heart development (GO:0061314)2.34702413
181endocardial cushion morphogenesis (GO:0003203)2.33716442
182cell proliferation involved in metanephros development (GO:0072203)2.33646324
183tachykinin receptor signaling pathway (GO:0007217)2.32880116
184tooth mineralization (GO:0034505)13.0302183
185sphingosine metabolic process (GO:0006670)10.3572376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.95946304
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.95588713
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.64323901
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.60009108
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.44530640
6CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.64698959
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.56527699
8CJUN_26792858_Chip-Seq_BT549_Human2.49101657
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.46533507
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44508744
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.38468795
12CLOCK_20551151_ChIP-Seq_293T_Human2.37381135
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.16689496
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12961225
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11194654
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06457892
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05713224
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.02940746
19* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.01602400
20NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01533721
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01533721
22EZH2_22144423_ChIP-Seq_EOC_Human2.00307565
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90192968
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89998200
25BRD4_25478319_ChIP-Seq_HGPS_Human1.83814625
26IGF1R_20145208_ChIP-Seq_DFB_Human1.83636733
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.81257142
28TP53_18474530_ChIP-ChIP_U2OS_Human1.80462589
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77666385
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77666385
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74528726
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73842339
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73094816
34VDR_22108803_ChIP-Seq_LS180_Human1.71365109
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65031114
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.61697205
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.61630872
38STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.57708612
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57227795
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55828878
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55828878
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.55609316
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52388308
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51949043
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51516940
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50806132
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49101866
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48947747
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47109439
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45717208
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45706854
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45036759
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45036759
54DROSHA_22980978_ChIP-Seq_HELA_Human1.44873109
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44314368
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.44196603
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44072250
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38604715
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.37178149
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36879134
61GBX2_23144817_ChIP-Seq_PC3_Human1.35853076
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34905818
63EGR1_19032775_ChIP-ChIP_M12_Human1.34590554
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31678889
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29835401
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29280694
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.26916967
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.26620106
69RXR_22108803_ChIP-Seq_LS180_Human1.24229255
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22863201
71SOX2_20726797_ChIP-Seq_SW620_Human1.22551737
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20887016
73SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20719485
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.19406539
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.19004838
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18245330
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18141975
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16271973
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.14956960
80TP53_16413492_ChIP-PET_HCT116_Human1.14734948
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11635631
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11060902
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10813643
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08266473
85TP63_23658742_ChIP-Seq_EP156T_Human1.07964145
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07255707
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05349834
88AR_19668381_ChIP-Seq_PC3_Human1.05017409
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04562140
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04494033
91* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03829518
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03045543
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02152290
94SOX2_19829295_ChIP-Seq_ESCs_Human1.00398832
95NANOG_19829295_ChIP-Seq_ESCs_Human1.00398832
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.00089097
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.00034462
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.99707420
99* FOXH1_21741376_ChIP-Seq_ESCs_Human0.99668356
100STAT1_20625510_ChIP-Seq_HELA_Human0.99289480
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98814672
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98740037
103ISL1_27105846_Chip-Seq_CPCs_Mouse0.98698378
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.98062730
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98058128
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.95998622
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.95998622
108SA1_22415368_ChIP-Seq_MEFs_Mouse0.95163560
109SMAD3_21741376_ChIP-Seq_EPCs_Human0.94804709
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94800998
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94672838
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.94578217
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.94118247
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93784976
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93598242
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93165563
117BCAT_22108803_ChIP-Seq_LS180_Human0.92051716
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91375202
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.90988286
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90879705
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90809325
122GATA3_21878914_ChIP-Seq_MCF-7_Human0.90752559
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90564571
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90451408
125ATF3_27146783_Chip-Seq_COLON_Human0.90384374
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90247743
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89910963
128HTT_18923047_ChIP-ChIP_STHdh_Human0.89646504
129* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89516322
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88938560
131AR_25329375_ChIP-Seq_VCAP_Human0.88717332
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88612110
133* CTCF_27219007_Chip-Seq_Bcells_Human0.88584681
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.88534639
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.88420482
136P300_19829295_ChIP-Seq_ESCs_Human0.88303473
137VDR_24787735_ChIP-Seq_THP-1_Human0.88091552
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.87837553
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87642530
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86623387
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.86511983
142AR_21572438_ChIP-Seq_LNCaP_Human0.86223216
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85416318
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.84149854
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83325014
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82625771
147* NFE2_27457419_Chip-Seq_LIVER_Mouse0.82368789
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.82083620
149STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81421685
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.81131025
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.79341926
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79138547
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78919443
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78083228
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77728582
156KDM2B_26808549_Chip-Seq_K562_Human0.77669470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.23010523
2MP0001542_abnormal_bone_strength6.18177728
3MP0005275_abnormal_skin_tensile6.09337428
4MP0005503_abnormal_tendon_morphology5.39752853
5MP0002837_dystrophic_cardiac_calcinosis5.19368384
6MP0003136_yellow_coat_color5.12110203
7MP0005171_absent_coat_pigmentation5.11006448
8MP0004185_abnormal_adipocyte_glucose4.32508442
9MP0005670_abnormal_white_adipose4.00136723
10MP0002653_abnormal_ependyma_morphology3.36102115
11MP0002896_abnormal_bone_mineralization3.04652309
12MP0004381_abnormal_hair_follicle3.03935528
13MP0003705_abnormal_hypodermis_morpholog2.95014714
14MP0003279_aneurysm2.94739564
15MP0006054_spinal_hemorrhage2.84003778
16MP0002998_abnormal_bone_remodeling2.77361530
17MP0009384_cardiac_valve_regurgitation2.49275933
18MP0004272_abnormal_basement_membrane2.47817696
19MP0005257_abnormal_intraocular_pressure2.33860740
20MP0003646_muscle_fatigue2.30233408
21MP0002060_abnormal_skin_morphology2.29514079
22MP0001958_emphysema2.27347868
23MP0003879_abnormal_hair_cell2.24872004
24MP0009250_abnormal_appendicular_skeleto2.14277655
25MP0000566_synostosis2.11992884
26MP0005508_abnormal_skeleton_morphology1.99185952
27MP0004130_abnormal_muscle_cell1.95169594
28MP0002295_abnormal_pulmonary_circulatio1.94397320
29MP0002115_abnormal_skeleton_extremities1.93496893
30MP0002108_abnormal_muscle_morphology1.85349978
31MP0000749_muscle_degeneration1.76898271
32MP0000432_abnormal_head_morphology1.75768455
33MP0003935_abnormal_craniofacial_develop1.75048950
34MP0005023_abnormal_wound_healing1.73435280
35MP0002876_abnormal_thyroid_physiology1.68168404
36MP0005666_abnormal_adipose_tissue1.64870233
37MP0003795_abnormal_bone_structure1.64535092
38MP0003890_abnormal_embryonic-extraembry1.63795001
39MP0000163_abnormal_cartilage_morphology1.60345423
40MP0003566_abnormal_cell_adhesion1.58544543
41MP0001299_abnormal_eye_distance/1.55971634
42MP0009278_abnormal_bone_marrow1.54690315
43MP0005390_skeleton_phenotype1.54281901
44MP0002113_abnormal_skeleton_development1.50299999
45MP0002971_abnormal_brown_adipose1.48365490
46MP0001243_abnormal_dermal_layer1.47293920
47MP0010030_abnormal_orbit_morphology1.47066630
48MP0001533_abnormal_skeleton_physiology1.43482582
49MP0005623_abnormal_meninges_morphology1.42780741
50MP0003959_abnormal_lean_body1.36230688
51MP0000762_abnormal_tongue_morphology1.30542665
52MP0001849_ear_inflammation1.30261594
53MP0003385_abnormal_body_wall1.28770413
54MP0002109_abnormal_limb_morphology1.27248139
55MP0002138_abnormal_hepatobiliary_system1.27187284
56MP0000569_abnormal_digit_pigmentation1.25900165
57MP0005167_abnormal_blood-brain_barrier1.24928501
58MP0001501_abnormal_sleep_pattern1.24234191
59MP0010352_gastrointestinal_tract_polyps1.20326417
60MP0002282_abnormal_trachea_morphology1.17587842
61MP0002877_abnormal_melanocyte_morpholog1.17335577
62MP0005375_adipose_tissue_phenotype1.12718897
63MP0002116_abnormal_craniofacial_bone1.10578429
64MP0004134_abnormal_chest_morphology1.06996855
65MP0003300_gastrointestinal_ulcer1.04581719
66MP0005075_abnormal_melanosome_morpholog1.04357557
67MP0000013_abnormal_adipose_tissue1.01195581
68MP0000733_abnormal_muscle_development1.00051710
69MP0002233_abnormal_nose_morphology0.99995426
70MP0000428_abnormal_craniofacial_morphol0.98677469
71MP0000462_abnormal_digestive_system0.98612911
72MP0003755_abnormal_palate_morphology0.95799852
73MP0003195_calcinosis0.95720210
74MP0005377_hearing/vestibular/ear_phenot0.95580558
75MP0003878_abnormal_ear_physiology0.95580558
76MP0002932_abnormal_joint_morphology0.95214614
77MP0003724_increased_susceptibility_to0.94483126
78MP0009053_abnormal_anal_canal0.94059355
79MP0003941_abnormal_skin_development0.92612248
80MP0002234_abnormal_pharynx_morphology0.92213386
81MP0003283_abnormal_digestive_organ0.90155894
82MP0003937_abnormal_limbs/digits/tail_de0.89676687
83MP0002095_abnormal_skin_pigmentation0.85499004
84MP0003091_abnormal_cell_migration0.84997942
85MP0002938_white_spotting0.83210157
86MP0003950_abnormal_plasma_membrane0.82701111
87MP0001915_intracranial_hemorrhage0.81575927
88MP0000049_abnormal_middle_ear0.80543356
89MP0002098_abnormal_vibrissa_morphology0.80352439
90MP0010234_abnormal_vibrissa_follicle0.79886363
91MP0001879_abnormal_lymphatic_vessel0.77807894
92MP0000230_abnormal_systemic_arterial0.77770463
93MP0000751_myopathy0.76351577
94MP0003137_abnormal_impulse_conducting0.76160475
95MP0010771_integument_phenotype0.75412898
96MP0005535_abnormal_body_temperature0.75143855
97MP0003453_abnormal_keratinocyte_physiol0.72462766
98MP0005620_abnormal_muscle_contractility0.70803476
99MP0004885_abnormal_endolymph0.69584762
100MP0003115_abnormal_respiratory_system0.69552009
101MP0000579_abnormal_nail_morphology0.69503921
102MP0002168_other_aberrant_phenotype0.69436746
103MP0002933_joint_inflammation0.69381426
104MP0004147_increased_porphyrin_level0.69307399
105MP0003942_abnormal_urinary_system0.68661957
106MP0005076_abnormal_cell_differentiation0.68304106
107MP0003638_abnormal_response/metabolism_0.67622749
108MP0005330_cardiomyopathy0.67431931
109MP0000613_abnormal_salivary_gland0.67036362
110MP0000537_abnormal_urethra_morphology0.66700940
111MP0009780_abnormal_chondrocyte_physiolo0.66164156
112MP0002089_abnormal_postnatal_growth/wei0.65646635
113MP0000534_abnormal_ureter_morphology0.65613679
114MP0004858_abnormal_nervous_system0.63303394
115MP0000767_abnormal_smooth_muscle0.63167009
116MP0005197_abnormal_uvea_morphology0.62181930
117MP0002254_reproductive_system_inflammat0.61905886
118MP0006138_congestive_heart_failure0.61614176
119MP0010329_abnormal_lipoprotein_level0.61418735
120MP0002111_abnormal_tail_morphology0.60252726
121MP0005501_abnormal_skin_physiology0.59346785
122MP0001177_atelectasis0.59259435
123MP0001661_extended_life_span0.58476850
124MP0005369_muscle_phenotype0.58463326
125MP0005164_abnormal_response_to0.58444419
126MP0000026_abnormal_inner_ear0.58078289
127MP0005448_abnormal_energy_balance0.57910069
128MP0000538_abnormal_urinary_bladder0.56397184
129MP0002177_abnormal_outer_ear0.55872542
130MP0003183_abnormal_peptide_metabolism0.54801127
131MP0001324_abnormal_eye_pigmentation0.54668785
132MP0009115_abnormal_fat_cell0.54211413
133MP0000377_abnormal_hair_follicle0.54151860
134MP0002909_abnormal_adrenal_gland0.53681890
135MP0002114_abnormal_axial_skeleton0.53561992
136MP0009379_abnormal_foot_pigmentation0.53451054
137MP0001346_abnormal_lacrimal_gland0.53055118
138MP0009764_decreased_sensitivity_to0.52896417
139MP0001270_distended_abdomen0.52001365
140MP0000759_abnormal_skeletal_muscle0.51657706
141MP0000343_altered_response_to0.51239557
142MP0003045_fibrosis0.50998880
143MP0002249_abnormal_larynx_morphology0.49380914
144MP0005365_abnormal_bile_salt0.49069972
145MP0000516_abnormal_urinary_system0.48284030
146MP0005367_renal/urinary_system_phenotyp0.48284030
147MP0002133_abnormal_respiratory_system0.47561814
148MP0005388_respiratory_system_phenotype0.47561814
149MP0002796_impaired_skin_barrier0.47153680
150MP0005334_abnormal_fat_pad0.46929167
151MP0000249_abnormal_blood_vessel0.46742053
152MP0002128_abnormal_blood_circulation0.46641883
153MP0003011_delayed_dark_adaptation0.45931062
154MP0002970_abnormal_white_adipose0.45214699
155MP0002075_abnormal_coat/hair_pigmentati0.45106528
156MP0003252_abnormal_bile_duct0.42892193
157MP0003448_altered_tumor_morphology0.41936657
158MP0005595_abnormal_vascular_smooth0.41598573
159MP0005187_abnormal_penis_morphology0.41268767
160MP0001348_abnormal_lacrimal_gland0.40870411
161MP0001614_abnormal_blood_vessel0.40854969
162MP0005193_abnormal_anterior_eye0.40493218
163MP0001175_abnormal_lung_morphology0.39831703

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)9.97201563
2Protrusio acetabuli (HP:0003179)8.00992386
3Premature rupture of membranes (HP:0001788)7.56652958
4Atrophic scars (HP:0001075)7.15969925
5Metaphyseal cupping (HP:0003021)5.81154750
6Focal motor seizures (HP:0011153)5.28396201
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.01416684
8Peritonitis (HP:0002586)4.86416774
9Abnormality of dentin (HP:0010299)4.74950566
10Parakeratosis (HP:0001036)4.65759256
11Soft skin (HP:0000977)4.51842993
12Aortic dissection (HP:0002647)4.50494272
13Congenital ichthyosiform erythroderma (HP:0007431)4.35770257
14Ulnar bowing (HP:0003031)4.27998454
15Flat cornea (HP:0007720)4.10683011
16Small epiphyses (HP:0010585)4.05053063
17Wormian bones (HP:0002645)4.00000511
18Broad metatarsal (HP:0001783)3.96707300
19Shallow orbits (HP:0000586)3.95224228
20Neonatal short-limb short stature (HP:0008921)3.93823125
21Biconcave vertebral bodies (HP:0004586)3.90965603
22Ankle contracture (HP:0006466)3.79295595
23Onycholysis (HP:0001806)3.79290512
24Genu recurvatum (HP:0002816)3.77377227
25Fragile skin (HP:0001030)3.76796717
26Blue sclerae (HP:0000592)3.65761758
27Bladder diverticulum (HP:0000015)3.62740966
28Femoral bowing (HP:0002980)3.59180651
29Follicular hyperkeratosis (HP:0007502)3.55588970
30Ulnar claw (HP:0001178)3.50826870
31Tibial bowing (HP:0002982)3.41735335
32Cupped ribs (HP:0000887)3.41271208
33Mesangial abnormality (HP:0001966)3.40098909
34Thyroid-stimulating hormone excess (HP:0002925)3.33319124
35Increased IgE level (HP:0003212)3.31482342
36Glomerulonephritis (HP:0000099)3.17209425
37Mitral valve prolapse (HP:0001634)3.14057743
38Radial bowing (HP:0002986)3.13611856
39Acanthocytosis (HP:0001927)3.05157654
40Distal arthrogryposis (HP:0005684)3.05067121
41Difficulty walking (HP:0002355)3.03022923
42Osteoarthritis (HP:0002758)3.01249644
43Hypophosphatemic rickets (HP:0004912)3.00417798
44Hypoplasia of the iris (HP:0007676)2.96843960
45Erythroderma (HP:0001019)2.93315101
46Spontaneous hematomas (HP:0007420)2.93028458
47Dilatation of the ascending aorta (HP:0005111)2.91686671
48Vertebral compression fractures (HP:0002953)2.90509699
49Cervical subluxation (HP:0003308)2.90349626
50Anterior segment dysgenesis (HP:0007700)2.89299018
51Bowing of the arm (HP:0006488)2.83858985
52Bowed forearm bones (HP:0003956)2.83858985
53Infantile muscular hypotonia (HP:0008947)2.81256978
54Nephritis (HP:0000123)2.80103920
55Hyperextensible skin (HP:0000974)2.78551002
56Decreased skull ossification (HP:0004331)2.77217473
57Fragile nails (HP:0001808)2.74549395
58Woolly hair (HP:0002224)2.74397332
59Proximal amyotrophy (HP:0007126)2.71581346
60Large for gestational age (HP:0001520)2.63856212
61Hypotrichosis (HP:0001006)2.62395035
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.60303787
63Osteolytic defects of the hand bones (HP:0009699)2.60303787
64Flared iliac wings (HP:0002869)2.59734049
65Abnormal delivery (HP:0001787)2.56731469
66Broad ribs (HP:0000885)2.55380590
67Milia (HP:0001056)2.54344665
68Vertebral arch anomaly (HP:0008438)2.52829224
69Type 1 muscle fiber predominance (HP:0003803)2.52805297
70Wide anterior fontanel (HP:0000260)2.51891092
71Platyspondyly (HP:0000926)2.50967888
72Mild short stature (HP:0003502)2.50185765
73Osteomalacia (HP:0002749)2.46260353
74Dialeptic seizures (HP:0011146)2.46245550
75Slender build (HP:0001533)2.46028338
76Pili torti (HP:0003777)2.45948714
77Breech presentation (HP:0001623)2.45216250
78Flattened epiphyses (HP:0003071)2.44954247
79Cerebral aneurysm (HP:0004944)2.44645719
80Aortic aneurysm (HP:0004942)2.44310327
81Coxa vara (HP:0002812)2.43776672
82Abnormality of skull ossification (HP:0002703)2.43140113
83Hematochezia (HP:0002573)2.42453470
84Bowel diverticulosis (HP:0005222)2.42200229
85Nonimmune hydrops fetalis (HP:0001790)2.42002140
86Scapular winging (HP:0003691)2.41770757
87Aplastic anemia (HP:0001915)2.39795878
88Deviation of the hallux (HP:0010051)2.38227121
89Round ear (HP:0100830)2.37958318
90Irregular vertebral endplates (HP:0003301)2.37756090
91Striae distensae (HP:0001065)2.34503995
92Spondylolisthesis (HP:0003302)2.34132603
93Neoplasm of the heart (HP:0100544)2.32694924
94Focal seizures (HP:0007359)2.31720239
95Abnormality of the costochondral junction (HP:0000919)2.30702708
96Congenital, generalized hypertrichosis (HP:0004540)2.30076532
97Absent frontal sinuses (HP:0002688)2.29829054
98Morphological abnormality of the middle ear (HP:0008609)2.29746276
99Abnormality of the anterior chamber (HP:0000593)2.29092571
100Hallux valgus (HP:0001822)2.29052814
101Nonprogressive disorder (HP:0003680)2.28110356
102Wide cranial sutures (HP:0010537)2.27873410
103Bell-shaped thorax (HP:0001591)2.25464076
104Flared metaphyses (HP:0003015)2.24546926
105Lack of skin elasticity (HP:0100679)2.24276985
106Rectal prolapse (HP:0002035)2.20636684
107Coronal craniosynostosis (HP:0004440)2.19387744
108Keratoconus (HP:0000563)2.16823310
109Increased corneal curvature (HP:0100692)2.16823310
110Abnormality of the vertebral endplates (HP:0005106)2.15761274
111Abnormality of the peritoneum (HP:0002585)2.15620130
112Premature loss of primary teeth (HP:0006323)2.15530700
113Abnormality of the acetabulum (HP:0003170)2.15399413
114Gangrene (HP:0100758)2.14372717
115Persistence of primary teeth (HP:0006335)2.13705745
116Papilledema (HP:0001085)2.13055199
117Joint laxity (HP:0001388)2.10175730
118Abnormality of the ischium (HP:0003174)2.09557858
119Overgrowth (HP:0001548)2.07639079
120Prominent supraorbital ridges (HP:0000336)2.06587102
121Widely patent fontanelles and sutures (HP:0004492)2.06156958
122Esophageal varix (HP:0002040)2.04963039
123Potter facies (HP:0002009)2.04431441
124Facial shape deformation (HP:0011334)2.04431441
125Elbow flexion contracture (HP:0002987)2.04203318
126Ectopia lentis (HP:0001083)2.04201550
127Hypercortisolism (HP:0001578)2.03174630
128Rickets (HP:0002748)2.02376714
129Rhizomelia (HP:0008905)2.01944511
130Increased density of long bones (HP:0006392)2.01833529
131Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00863591
132Corneal erosion (HP:0200020)2.00431886
133Muscle fiber splitting (HP:0003555)1.99687200
134Spinal rigidity (HP:0003306)1.98262265
135Tubular atrophy (HP:0000092)1.98003622
136Conjunctival hamartoma (HP:0100780)1.97981344
137Severe Myopia (HP:0011003)1.96527637
138Broad long bones (HP:0005622)1.96322401
139Colitis (HP:0002583)1.96276561
140Bone cyst (HP:0012062)1.95349024
141Aortic valve stenosis (HP:0001650)1.95314324
142Corneal dystrophy (HP:0001131)1.94751637
143Duplicated collecting system (HP:0000081)1.94416582
144Visceral angiomatosis (HP:0100761)1.93721448
145Oligomenorrhea (HP:0000876)1.92453742
146Venous insufficiency (HP:0005293)1.91733768
147Right ventricular cardiomyopathy (HP:0011663)1.89159059
148Abnormality of the frontal sinuses (HP:0002687)1.89079901
149Short middle phalanx of the 5th finger (HP:0004220)1.88833079
150Wrist flexion contracture (HP:0001239)1.87127628
151Bilateral sensorineural hearing impairment (HP:0008619)1.86111439
152Narrow nasal bridge (HP:0000446)1.85344988
153Spinal cord lesions (HP:0100561)1.84285607
154Syringomyelia (HP:0003396)1.84285607
155Osteopenia (HP:0000938)1.83867428
156Turricephaly (HP:0000262)1.83714095
157Venous abnormality (HP:0002624)1.83278903
158Craniofacial hyperostosis (HP:0004493)1.82678140
159Alopecia of scalp (HP:0002293)1.82118147
160Polar cataract (HP:0010696)1.81515705
161Limited elbow extension (HP:0001377)1.80241147
162Hypoplastic ischia (HP:0003175)1.79669884
163Palmoplantar keratoderma (HP:0000982)1.79595025
164Increased connective tissue (HP:0009025)1.79055656
165Decreased circulating renin level (HP:0003351)1.76843795
166Ulnar deviation of the wrist (HP:0003049)1.76040823
167Hemangiomatosis (HP:0007461)1.75082079
168Peripheral hypomyelination (HP:0007182)1.72506565
169Abnormality of the vocal cords (HP:0008777)1.72466738
170Retinal detachment (HP:0000541)1.71978684
171Stroke (HP:0001297)1.71755543
172Tarsal synostosis (HP:0008368)1.70692827
173Acanthosis nigricans (HP:0000956)1.70005200
174Conjunctival telangiectasia (HP:0000524)1.68606228
175Steppage gait (HP:0003376)1.68255460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.57560436
2EPHA34.87468072
3PDGFRA3.67502409
4FGFR23.50379239
5SIK13.45000257
6ADRBK23.00364708
7LATS12.89753577
8PKN22.82760960
9TTN2.53949387
10FRK2.48495582
11TRIB32.46013657
12PRKD32.25738651
13NLK2.17487360
14TRPM72.16955899
15STK382.06161951
16FGFR12.03228211
17LATS21.99164423
18RIPK11.97068757
19FLT31.88597607
20MAPK151.84524846
21MAP3K31.75234167
22MAP2K21.73793620
23TGFBR11.72917525
24ACVR1B1.68443919
25EPHB21.64885762
26TIE11.63715228
27TGFBR21.53280503
28FER1.52200394
29PLK21.50773391
30PDGFRB1.46765638
31BMX1.45805880
32PIK3CA1.44977016
33ZAK1.44715508
34STK31.36709998
35NTRK11.32388153
36IRAK31.26320191
37BMPR1B1.25832086
38PRKAA21.24817271
39GRK71.22783277
40CDK61.22436805
41PAK31.21952957
42EEF2K1.21349710
43KIT1.18731519
44PAK21.16512572
45PIK3CG1.16350238
46MELK1.15690776
47FGFR31.14980967
48LRRK21.14072055
49MET1.10223575
50ERN11.07984252
51PTK21.07331502
52JAK11.06167871
53ROCK10.96930658
54PTK60.91732634
55GRK50.89636762
56PAK40.88975261
57PINK10.86543830
58MAPK70.84357099
59KSR20.82528871
60NEK90.81924597
61RET0.79225552
62OBSCN0.78829652
63PDPK10.78561053
64MAPKAPK50.77018017
65IRAK10.75296498
66NEK20.72512159
67CSF1R0.70840212
68MAPK120.69936834
69DYRK1B0.69215960
70PRKCH0.66933443
71PRKCE0.66560760
72WNK30.65205029
73FGFR40.62722797
74EIF2AK20.60773787
75SCYL20.60605855
76INSR0.58858599
77PDK20.57308943
78PIM20.56409579
79PRKD10.56218669
80STK38L0.55789021
81IGF1R0.53046350
82ROCK20.52583063
83JAK30.52421536
84GSK3A0.52365771
85MAPK40.51445177
86PRKG20.51408835
87MTOR0.50812957
88TESK10.50242696
89CSNK1A10.48636131
90PTK2B0.47967148
91EPHA20.46222440
92ERBB30.45902197
93NUAK10.45248302
94CAMKK20.41930425
95EPHB10.41835315
96MAPKAPK30.41638892
97ADRBK10.39864035
98TAF10.39551285
99PRKD20.38722058
100KSR10.38142483
101NME10.38050511
102MARK20.37255068
103SRC0.37171833
104OXSR10.36930774
105MAPK30.36755960
106TYK20.36213716
107CAMK40.34805368
108PDK40.34696339
109PDK30.34696339
110MYLK0.34024293
111CAMKK10.33967843
112LMTK20.33302701
113WNK40.32391495
114MAP3K10.31263331
115NTRK30.30844241
116MAP3K20.29767964
117MAP2K10.29764086
118ABL20.29448553
119PAK60.28276421
120NTRK20.27964616
121LIMK10.27810248
122MOS0.27237150
123CAMK1D0.26923765
124MAPK10.26686748
125PRKCG0.26388091
126MAP3K120.25499382
127CSNK1G10.25152209
128TYRO30.24428070
129CDC42BPA0.23585454
130MAP3K110.23441049
131NME20.22682923
132FYN0.22444401
133TNK20.22041282
134RIPK40.21843980
135CASK0.21154185
136RPS6KA40.20383477
137PKN10.20297220
138ABL10.20006877
139CDK30.18650950
140MAP3K70.18602188
141AKT20.18480914
142STK100.18127308
143PLK30.18121458
144TBK10.18070161
145ILK0.16558461
146GRK10.15557734
147STK110.15367630
148CAMK2A0.14009515
149IKBKB0.13227771
150STK390.12070581
151PRKACA0.10929823
152CHUK0.10589150
153IRAK40.10229912
154CAMK10.08957791
155CSNK1A1L0.08956169
156MAPK80.08746176
157TLK10.08596694

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045126.07048334
2Protein digestion and absorption_Homo sapiens_hsa049743.92179868
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58148032
4* Focal adhesion_Homo sapiens_hsa045103.38526135
5Dorso-ventral axis formation_Homo sapiens_hsa043203.31698563
6Phototransduction_Homo sapiens_hsa047443.30164953
7Sphingolipid metabolism_Homo sapiens_hsa006002.71863908
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.64671131
9Amoebiasis_Homo sapiens_hsa051462.44186146
10Folate biosynthesis_Homo sapiens_hsa007902.24089513
11Malaria_Homo sapiens_hsa051442.22505430
12Proteoglycans in cancer_Homo sapiens_hsa052052.18638944
13Phenylalanine metabolism_Homo sapiens_hsa003602.08391454
14Histidine metabolism_Homo sapiens_hsa003401.98550014
15* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.96678609
16Basal cell carcinoma_Homo sapiens_hsa052171.90144011
17Bladder cancer_Homo sapiens_hsa052191.90115738
18TGF-beta signaling pathway_Homo sapiens_hsa043501.89109812
19Small cell lung cancer_Homo sapiens_hsa052221.83290973
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80089069
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79570472
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75580044
23Adherens junction_Homo sapiens_hsa045201.70803499
24Hippo signaling pathway_Homo sapiens_hsa043901.66741956
25Morphine addiction_Homo sapiens_hsa050321.63690265
26Ovarian steroidogenesis_Homo sapiens_hsa049131.62699042
27Glycerolipid metabolism_Homo sapiens_hsa005611.62515508
28Nicotine addiction_Homo sapiens_hsa050331.55812617
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53055456
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53037856
31Melanoma_Homo sapiens_hsa052181.50418698
32Wnt signaling pathway_Homo sapiens_hsa043101.48326843
33Dilated cardiomyopathy_Homo sapiens_hsa054141.48266072
34Tryptophan metabolism_Homo sapiens_hsa003801.43935528
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41937948
36Hedgehog signaling pathway_Homo sapiens_hsa043401.38314943
37PPAR signaling pathway_Homo sapiens_hsa033201.36866097
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36406812
39Prostate cancer_Homo sapiens_hsa052151.31929955
40Taste transduction_Homo sapiens_hsa047421.30823709
41* MicroRNAs in cancer_Homo sapiens_hsa052061.26769925
42Platelet activation_Homo sapiens_hsa046111.26126914
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24524165
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.23544491
45Glioma_Homo sapiens_hsa052141.23355600
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23327975
47Thyroid hormone synthesis_Homo sapiens_hsa049181.22129640
48Chronic myeloid leukemia_Homo sapiens_hsa052201.21854356
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19076524
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18264750
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17613693
52ABC transporters_Homo sapiens_hsa020101.16510611
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15166148
54Toxoplasmosis_Homo sapiens_hsa051451.12969563
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11230556
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09060141
57Phagosome_Homo sapiens_hsa041451.08325969
58Pathways in cancer_Homo sapiens_hsa052001.05653326
59Melanogenesis_Homo sapiens_hsa049161.03581561
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.03376497
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02869469
62Nitrogen metabolism_Homo sapiens_hsa009100.98882860
63Pancreatic cancer_Homo sapiens_hsa052120.98460483
64Calcium signaling pathway_Homo sapiens_hsa040200.98414021
65Axon guidance_Homo sapiens_hsa043600.98060774
66Tyrosine metabolism_Homo sapiens_hsa003500.97415679
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.97039856
68Linoleic acid metabolism_Homo sapiens_hsa005910.93845443
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93300827
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92829645
71Rap1 signaling pathway_Homo sapiens_hsa040150.92723300
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91290178
73Vitamin digestion and absorption_Homo sapiens_hsa049770.90780604
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.89631765
75Staphylococcus aureus infection_Homo sapiens_hsa051500.84215511
76Estrogen signaling pathway_Homo sapiens_hsa049150.83195423
77Gap junction_Homo sapiens_hsa045400.83100962
78Notch signaling pathway_Homo sapiens_hsa043300.82166519
79Salivary secretion_Homo sapiens_hsa049700.80280393
80Fatty acid degradation_Homo sapiens_hsa000710.80089794
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78783796
82cAMP signaling pathway_Homo sapiens_hsa040240.78045159
83Serotonergic synapse_Homo sapiens_hsa047260.77999651
84Tight junction_Homo sapiens_hsa045300.77648771
85GABAergic synapse_Homo sapiens_hsa047270.77377989
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76026378
87Olfactory transduction_Homo sapiens_hsa047400.76001610
88Prion diseases_Homo sapiens_hsa050200.75908508
89African trypanosomiasis_Homo sapiens_hsa051430.75315990
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75291498
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.72992230
92Glutamatergic synapse_Homo sapiens_hsa047240.72223871
93Arachidonic acid metabolism_Homo sapiens_hsa005900.71354918
94Renal cell carcinoma_Homo sapiens_hsa052110.69612472
95GnRH signaling pathway_Homo sapiens_hsa049120.69388091
96p53 signaling pathway_Homo sapiens_hsa041150.67922217
97HTLV-I infection_Homo sapiens_hsa051660.66207448
98Circadian entrainment_Homo sapiens_hsa047130.65618290
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.64899792
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64316543
101TNF signaling pathway_Homo sapiens_hsa046680.64138263
102Rheumatoid arthritis_Homo sapiens_hsa053230.61640501
103mTOR signaling pathway_Homo sapiens_hsa041500.61551780
104Vibrio cholerae infection_Homo sapiens_hsa051100.61522042
105HIF-1 signaling pathway_Homo sapiens_hsa040660.61395562
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61114989
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60508139
108beta-Alanine metabolism_Homo sapiens_hsa004100.60397557
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59429967
110Gastric acid secretion_Homo sapiens_hsa049710.58061010
111Ether lipid metabolism_Homo sapiens_hsa005650.57013794
112Insulin resistance_Homo sapiens_hsa049310.56941264
113Hepatitis B_Homo sapiens_hsa051610.56640822
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.56257862
115Asthma_Homo sapiens_hsa053100.54989429
116Fatty acid biosynthesis_Homo sapiens_hsa000610.54619170
117Ras signaling pathway_Homo sapiens_hsa040140.54253642
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.53977574
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52496717
120Renin-angiotensin system_Homo sapiens_hsa046140.52189823
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51426412
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50658581
123FoxO signaling pathway_Homo sapiens_hsa040680.49313497
124Lysine degradation_Homo sapiens_hsa003100.48830135
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47526445
126Sulfur relay system_Homo sapiens_hsa041220.47210900
127Sulfur metabolism_Homo sapiens_hsa009200.46845364
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46709352
129Endometrial cancer_Homo sapiens_hsa052130.46584061
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45527020
131Butanoate metabolism_Homo sapiens_hsa006500.45350872
132Mineral absorption_Homo sapiens_hsa049780.44149934
133Lysosome_Homo sapiens_hsa041420.43948948
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43725718
135Viral myocarditis_Homo sapiens_hsa054160.42999844
136Non-small cell lung cancer_Homo sapiens_hsa052230.42321809
137VEGF signaling pathway_Homo sapiens_hsa043700.41846348
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40478020
139Osteoclast differentiation_Homo sapiens_hsa043800.39910885
140Arginine and proline metabolism_Homo sapiens_hsa003300.39879160
141Colorectal cancer_Homo sapiens_hsa052100.38568877
142Acute myeloid leukemia_Homo sapiens_hsa052210.38447261
143Retinol metabolism_Homo sapiens_hsa008300.38081704
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37846535
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.37793106
146Shigellosis_Homo sapiens_hsa051310.35998574
147Complement and coagulation cascades_Homo sapiens_hsa046100.35959355
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35001402
149AMPK signaling pathway_Homo sapiens_hsa041520.34619144
150Endocytosis_Homo sapiens_hsa041440.33462543
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.32726856
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31530838
153Viral carcinogenesis_Homo sapiens_hsa052030.30216506
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28339147
155Bile secretion_Homo sapiens_hsa049760.28274084
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.27922328
157Oxytocin signaling pathway_Homo sapiens_hsa049210.26792147
158Long-term depression_Homo sapiens_hsa047300.24354389
159Renin secretion_Homo sapiens_hsa049240.22840923

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