TNNC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.67750963
2sarcomere organization (GO:0045214)9.59665654
3myofibril assembly (GO:0030239)8.44404019
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.22538784
5* muscle filament sliding (GO:0030049)8.01482853
6* actin-myosin filament sliding (GO:0033275)8.01482853
7negative regulation of potassium ion transmembrane transport (GO:1901380)7.42264023
8* skeletal muscle contraction (GO:0003009)7.31876235
9* cardiac muscle contraction (GO:0060048)7.04978792
10cardiac muscle cell development (GO:0055013)6.94188685
11* actin-mediated cell contraction (GO:0070252)6.66949688
12cardiac cell development (GO:0055006)6.53193326
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.46389446
14* cardiac muscle tissue morphogenesis (GO:0055008)6.37548625
15tricarboxylic acid cycle (GO:0006099)6.35037448
16cardiac muscle hypertrophy (GO:0003300)6.30925336
17regulation of relaxation of muscle (GO:1901077)6.30350560
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.29209120
19actomyosin structure organization (GO:0031032)6.27413711
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.20878164
21adult heart development (GO:0007512)6.18277562
22heart contraction (GO:0060047)6.10346009
23heart process (GO:0003015)6.10346009
24regulation of sarcomere organization (GO:0060297)6.03463388
25* ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.98227361
26striated muscle hypertrophy (GO:0014897)5.96357944
27creatine metabolic process (GO:0006600)5.93210654
28plasma membrane repair (GO:0001778)5.91129109
29response to muscle activity (GO:0014850)5.73590159
30ventricular cardiac muscle cell action potential (GO:0086005)5.69821922
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.68625052
32* muscle tissue morphogenesis (GO:0060415)5.67994855
33regulation of skeletal muscle contraction (GO:0014819)5.62801210
34* striated muscle contraction (GO:0006941)5.56279218
35bundle of His cell to Purkinje myocyte communication (GO:0086069)5.54217650
36heart trabecula formation (GO:0060347)5.49213755
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.41357882
38muscle hypertrophy (GO:0014896)5.30238242
39regulation of the force of heart contraction (GO:0002026)5.28355330
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.20995837
41regulation of striated muscle contraction (GO:0006942)5.19784893
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.04105922
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.98370196
44* actin filament-based movement (GO:0030048)4.93915908
45regulation of cell communication by electrical coupling (GO:0010649)4.86814828
46* regulation of actin filament-based movement (GO:1903115)4.86731737
47energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85449667
48ATP synthesis coupled proton transport (GO:0015986)4.85449667
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.79536687
50sarcoplasmic reticulum calcium ion transport (GO:0070296)4.73275153
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.73091780
52skeletal muscle adaptation (GO:0043501)4.70318154
53regulation of membrane repolarization (GO:0060306)4.66908672
54skeletal muscle fiber development (GO:0048741)4.64552038
55negative regulation of striated muscle cell apoptotic process (GO:0010664)4.62359682
56carnitine shuttle (GO:0006853)4.56623420
57regulation of acyl-CoA biosynthetic process (GO:0050812)4.54846111
58regulation of cardioblast differentiation (GO:0051890)4.54741990
59cell communication involved in cardiac conduction (GO:0086065)4.53768076
60cardiac muscle adaptation (GO:0014887)4.46224747
61cardiac muscle hypertrophy in response to stress (GO:0014898)4.46224747
62muscle hypertrophy in response to stress (GO:0003299)4.46224747
63oxidative phosphorylation (GO:0006119)4.41259702
64negative regulation of protein localization to cell surface (GO:2000009)4.33649426
65muscle fiber development (GO:0048747)4.33194187
66respiratory electron transport chain (GO:0022904)4.32022489
67myotube cell development (GO:0014904)4.30638397
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.28421660
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.28338332
70ventricular cardiac muscle cell development (GO:0055015)4.23379869
71regulation of cofactor metabolic process (GO:0051193)4.20302282
72regulation of coenzyme metabolic process (GO:0051196)4.20302282
73electron transport chain (GO:0022900)4.19751434
74regulation of cardiac muscle contraction (GO:0055117)4.14532522
75cell communication by electrical coupling (GO:0010644)4.11896259
76regulation of heart rate (GO:0002027)4.08807188
77cardiac muscle cell action potential involved in contraction (GO:0086002)4.03417453
78skeletal muscle tissue development (GO:0007519)4.02639371
79cardiac muscle cell action potential (GO:0086001)3.97991089
80negative regulation of potassium ion transport (GO:0043267)3.97256108
81striated muscle cell development (GO:0055002)3.96630037
82muscle cell fate commitment (GO:0042693)3.96089745
83regulation of cardiac muscle cell contraction (GO:0086004)3.95049139
84fatty acid transmembrane transport (GO:1902001)3.91852767
85glycogen catabolic process (GO:0005980)3.91044266
86muscle cell cellular homeostasis (GO:0046716)3.88216684
87regulation of calcium ion transmembrane transport (GO:1903169)3.85445942
88muscle adaptation (GO:0043500)3.85337321
89glucan biosynthetic process (GO:0009250)3.84424963
90glycogen biosynthetic process (GO:0005978)3.84424963
91relaxation of cardiac muscle (GO:0055119)3.80236525
92regulation of heart contraction (GO:0008016)3.79852599
93* regulation of ATP catabolic process (GO:1903289)3.75490359
94* regulation of ATPase activity (GO:0043462)3.75490359
95glucan catabolic process (GO:0009251)3.66337419
96striated muscle atrophy (GO:0014891)3.62446507
97regulation of striated muscle cell apoptotic process (GO:0010662)3.61992104
98positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.60067103
99NADH metabolic process (GO:0006734)3.58436165
100cardiac conduction (GO:0061337)3.57426826
101response to inactivity (GO:0014854)3.57223361
102trabecula formation (GO:0060343)3.55972425
103* muscle contraction (GO:0006936)3.55298898
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53582565
105negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.50493920
106negative regulation of calcium ion transmembrane transport (GO:1903170)3.50493920
107positive regulation of myotube differentiation (GO:0010831)3.49773401
108cardiac chamber formation (GO:0003207)3.48669278
109regulation of heart rate by cardiac conduction (GO:0086091)3.46240029
110muscle organ development (GO:0007517)3.46233840
111regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46140619
112* regulation of muscle system process (GO:0090257)3.46070306
113regulation of myoblast differentiation (GO:0045661)3.45701039
114muscle structure development (GO:0061061)3.45034073
115cellular polysaccharide catabolic process (GO:0044247)3.43757399
116* regulation of muscle contraction (GO:0006937)3.42089936
117striated muscle adaptation (GO:0014888)3.40941478
118muscle cell development (GO:0055001)3.40845878
119* muscle system process (GO:0003012)3.36172626
120regulation of sulfur metabolic process (GO:0042762)3.34969993
121positive regulation of cation channel activity (GO:2001259)3.34340625
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.32712483
123carnitine transmembrane transport (GO:1902603)3.30857614
124positive regulation of heart rate (GO:0010460)3.30491141
125relaxation of muscle (GO:0090075)3.29459051
126negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29117547
127cardiac ventricle formation (GO:0003211)3.28649454
1282-oxoglutarate metabolic process (GO:0006103)3.26524502
129positive regulation of heart contraction (GO:0045823)3.26238593
130muscle atrophy (GO:0014889)3.22224572
131ATP biosynthetic process (GO:0006754)3.19749864
132regulation of calcium ion transmembrane transporter activity (GO:1901019)3.17118735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.87558659
2EP300_21415370_ChIP-Seq_HL-1_Mouse6.08138406
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.18161685
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.70588130
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.51073578
6TBX20_22328084_ChIP-Seq_HEART_Mouse4.51073578
7MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.94914360
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.82564777
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.59145415
10GATA4_21415370_ChIP-Seq_HL-1_Mouse3.08612020
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96510064
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.85465563
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70314105
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.65984310
15ZNF263_19887448_ChIP-Seq_K562_Human2.61990481
16* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45289484
17NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.16898616
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10914472
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.10801573
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96183560
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94237362
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.89213407
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74161300
24EZH2_22144423_ChIP-Seq_EOC_Human1.66987391
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65016245
26ISL1_27105846_Chip-Seq_CPCs_Mouse1.64254816
27GATA1_22025678_ChIP-Seq_K562_Human1.59916250
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59675968
29CLOCK_20551151_ChIP-Seq_293T_Human1.58240987
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.55574832
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54534973
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52208939
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50804960
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48629898
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.32715998
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32258312
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31904492
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20491900
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.20440698
40CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17492203
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17163454
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14311605
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14054843
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.13680397
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12308281
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12064538
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11501483
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09415837
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.09176051
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08180494
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06788839
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.06106162
53CTCF_27219007_Chip-Seq_Bcells_Human1.06073995
54ZNF274_21170338_ChIP-Seq_K562_Hela1.01995914
55GATA1_19941826_ChIP-Seq_K562_Human1.00940141
56STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00503382
57KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98552540
58RARB_27405468_Chip-Seq_BRAIN_Mouse0.98349646
59* TP63_22573176_ChIP-Seq_HFKS_Human0.97069170
60SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94569610
61LXR_22158963_ChIP-Seq_LIVER_Mouse0.94505175
62SPI1_20517297_ChIP-Seq_HL60_Human0.93632455
63RXR_22158963_ChIP-Seq_LIVER_Mouse0.93614940
64MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92866383
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91549295
66PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91231069
67CJUN_26792858_Chip-Seq_BT549_Human0.90545421
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90276621
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89487146
70TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88781514
71SMAD3_21741376_ChIP-Seq_HESCs_Human0.88489168
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88186144
73* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87623787
74* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86721322
75RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86577868
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85967483
77NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85967483
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84900898
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84619221
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.84172119
81OCT4_20526341_ChIP-Seq_ESCs_Human0.84161638
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.84107408
83ATF3_27146783_Chip-Seq_COLON_Human0.83697516
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.83431872
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.83179659
86PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83084506
87KDM2B_26808549_Chip-Seq_DND41_Human0.82969987
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82582891
89CBX2_27304074_Chip-Seq_ESCs_Mouse0.82552710
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82227887
91* MYC_27129775_Chip-Seq_CORNEA_Mouse0.81614359
92GF1_26923725_Chip-Seq_HPCs_Mouse0.80179056
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80127756
94* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79857862
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79141842
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.79121152
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79049493
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78294023
99BCAT_22108803_ChIP-Seq_LS180_Human0.78291256
100RACK7_27058665_Chip-Seq_MCF-7_Human0.77933052
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77824021
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77808597
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77424683
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77061296
105VDR_22108803_ChIP-Seq_LS180_Human0.76449950
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76274037
107GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76037592
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75669141
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75668702
110HTT_18923047_ChIP-ChIP_STHdh_Human0.75471700
111TP53_23651856_ChIP-Seq_MEFs_Mouse0.73656085
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73648641
113JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73156083
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73146348
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.72995959
116GATA2_19941826_ChIP-Seq_K562_Human0.72659204
117DROSHA_22980978_ChIP-Seq_HELA_Human0.72442510
118FOXH1_21741376_ChIP-Seq_ESCs_Human0.72348305
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.72150113
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71985581
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71911119
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.71646658
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.71581259
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71529982
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70813128
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69825378
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69335659
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.69044035
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68713888
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67817981
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.67745341
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.67182829
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.67084509
134LXR_22292898_ChIP-Seq_THP-1_Human0.64765188
135EZH2_18974828_ChIP-Seq_MESCs_Mouse0.62721678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.58606043
2MP0004084_abnormal_cardiac_muscle6.34011634
3MP0003646_muscle_fatigue4.94623914
4MP0000751_myopathy4.92247224
5MP0004215_abnormal_myocardial_fiber4.81472819
6MP0004036_abnormal_muscle_relaxation4.50826348
7MP0000749_muscle_degeneration4.34145407
8MP0005330_cardiomyopathy4.09077349
9MP0002972_abnormal_cardiac_muscle3.44736378
10MP0004087_abnormal_muscle_fiber3.18808659
11MP0008775_abnormal_heart_ventricle3.17170591
12MP0003137_abnormal_impulse_conducting3.00039220
13MP0005620_abnormal_muscle_contractility2.81195814
14MP0010630_abnormal_cardiac_muscle2.79493998
15MP0005385_cardiovascular_system_phenoty2.74855063
16MP0001544_abnormal_cardiovascular_syste2.74855063
17MP0006138_congestive_heart_failure2.61738243
18MP0000750_abnormal_muscle_regeneration2.60520482
19MP0002106_abnormal_muscle_physiology2.54393405
20MP0003828_pulmonary_edema2.50467403
21MP0004484_altered_response_of2.46304351
22MP0004085_abnormal_heartbeat2.30855926
23MP0004145_abnormal_muscle_electrophysio2.30389433
24MP0002269_muscular_atrophy2.28769677
25MP0004510_myositis2.20164752
26MP0003221_abnormal_cardiomyocyte_apopto2.17645162
27MP0004130_abnormal_muscle_cell2.07329373
28MP0005369_muscle_phenotype2.04584924
29MP0002127_abnormal_cardiovascular_syste1.92665876
30MP0000759_abnormal_skeletal_muscle1.90992185
31MP0000747_muscle_weakness1.90669278
32MP0003950_abnormal_plasma_membrane1.87828182
33MP0006036_abnormal_mitochondrial_physio1.71488579
34MP0004233_abnormal_muscle_weight1.66861532
35MP0003567_abnormal_fetal_cardiomyocyte1.59975954
36MP0002332_abnormal_exercise_endurance1.30742182
37MP0000266_abnormal_heart_morphology1.22924343
38MP0003279_aneurysm1.19190115
39MP0010368_abnormal_lymphatic_system1.12154052
40MP0001661_extended_life_span1.12045365
41MP0005451_abnormal_body_composition1.11173407
42MP0000343_altered_response_to1.08534105
43MP0005666_abnormal_adipose_tissue1.07204283
44MP0002234_abnormal_pharynx_morphology1.05787097
45MP0004270_analgesia1.02166868
46MP0006035_abnormal_mitochondrial_morpho1.00658587
47MP0005670_abnormal_white_adipose0.99317536
48MP0005165_increased_susceptibility_to0.98506856
49MP0002128_abnormal_blood_circulation0.84328971
50MP0003566_abnormal_cell_adhesion0.84053590
51MP0000230_abnormal_systemic_arterial0.81918949
52MP0005266_abnormal_metabolism0.75765735
53MP0005623_abnormal_meninges_morphology0.74307269
54MP0004272_abnormal_basement_membrane0.74267802
55MP0002108_abnormal_muscle_morphology0.74208806
56MP0000767_abnormal_smooth_muscle0.73899041
57MP0003806_abnormal_nucleotide_metabolis0.67231698
58MP0005375_adipose_tissue_phenotype0.67171299
59MP0001879_abnormal_lymphatic_vessel0.63978461
60MP0000733_abnormal_muscle_development0.62535884
61MP0004185_abnormal_adipocyte_glucose0.59830075
62MP0003045_fibrosis0.59577748
63MP0009780_abnormal_chondrocyte_physiolo0.58742514
64MP0009384_cardiac_valve_regurgitation0.56305832
65MP0002925_abnormal_cardiovascular_devel0.55942097
66MP0003984_embryonic_growth_retardation0.55594171
67MP0002088_abnormal_embryonic_growth/wei0.55087065
68MP0001299_abnormal_eye_distance/0.53589158
69MP0003705_abnormal_hypodermis_morpholog0.52556824
70MP0002822_catalepsy0.51855930
71MP0008438_abnormal_cutaneous_collagen0.48800007
72MP0003122_maternal_imprinting0.45601083
73MP0001784_abnormal_fluid_regulation0.44645034
74MP0001614_abnormal_blood_vessel0.42898627
75MP0002909_abnormal_adrenal_gland0.42521492
76MP0008569_lethality_at_weaning0.40821218
77MP0004043_abnormal_pH_regulation0.40019944
78MP0005187_abnormal_penis_morphology0.39876713
79MP0005319_abnormal_enzyme/_coenzyme0.39048366
80MP0002971_abnormal_brown_adipose0.38725548
81MP0003941_abnormal_skin_development0.37758427
82MP0003948_abnormal_gas_homeostasis0.35790756
83MP0000003_abnormal_adipose_tissue0.34505361
84MP0004147_increased_porphyrin_level0.34117052
85MP0000013_abnormal_adipose_tissue0.33560693
86MP0000372_irregular_coat_pigmentation0.33471391
87MP0005584_abnormal_enzyme/coenzyme_acti0.33154670
88MP0010030_abnormal_orbit_morphology0.33141007
89MP0005595_abnormal_vascular_smooth0.33044206
90MP0001672_abnormal_embryogenesis/_devel0.32899427
91MP0005380_embryogenesis_phenotype0.32899427
92MP0002078_abnormal_glucose_homeostasis0.31519406
93MP0003879_abnormal_hair_cell0.29801603
94MP0004134_abnormal_chest_morphology0.28701494
95MP0002638_abnormal_pupillary_reflex0.28515906
96MP0005275_abnormal_skin_tensile0.28000667
97MP0002133_abnormal_respiratory_system0.26496281
98MP0005388_respiratory_system_phenotype0.26496281
99MP0005167_abnormal_blood-brain_barrier0.25995098
100MP0003656_abnormal_erythrocyte_physiolo0.25625055
101MP0001727_abnormal_embryo_implantation0.25205457
102MP0005377_hearing/vestibular/ear_phenot0.23915376
103MP0003878_abnormal_ear_physiology0.23915376
104MP0009250_abnormal_appendicular_skeleto0.23093372
105MP0005334_abnormal_fat_pad0.21405184
106MP0002114_abnormal_axial_skeleton0.20689769
107MP0005503_abnormal_tendon_morphology0.20440375
108MP0002896_abnormal_bone_mineralization0.20401055
109MP0005452_abnormal_adipose_tissue0.20165333
110MP0005386_behavior/neurological_phenoty0.19902747
111MP0004924_abnormal_behavior0.19902747
112MP0009672_abnormal_birth_weight0.19122760
113MP0000249_abnormal_blood_vessel0.18672550
114MP0005535_abnormal_body_temperature0.18634362
115MP0003385_abnormal_body_wall0.18610338
116MP0005332_abnormal_amino_acid0.18609065
117MP0004142_abnormal_muscle_tone0.18162276
118MP0005166_decreased_susceptibility_to0.17839276
119MP0008961_abnormal_basal_metabolism0.16652322
120MP0005376_homeostasis/metabolism_phenot0.15990984
121MP0001175_abnormal_lung_morphology0.14921030
122MP0002295_abnormal_pulmonary_circulatio0.14891312
123MP0003935_abnormal_craniofacial_develop0.13147615
124MP0000762_abnormal_tongue_morphology0.12338238

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.41700587
2Ventricular tachycardia (HP:0004756)7.07106407
3Calf muscle hypertrophy (HP:0008981)6.64399365
4Atrial fibrillation (HP:0005110)6.37965852
5Exercise-induced muscle cramps (HP:0003710)6.11227541
6Muscle hypertrophy of the lower extremities (HP:0008968)5.98812274
7Primary atrial arrhythmia (HP:0001692)5.95336244
8Supraventricular tachycardia (HP:0004755)5.76410479
9Exercise-induced myalgia (HP:0003738)5.70620983
10Supraventricular arrhythmia (HP:0005115)5.64554302
11Abnormality of the left ventricular outflow tract (HP:0011103)5.53695479
12Subaortic stenosis (HP:0001682)5.53695479
13Abnormality of the calf musculature (HP:0001430)5.52609287
14* Lipoatrophy (HP:0100578)5.43176112
15Muscle fiber splitting (HP:0003555)5.25988891
16Right ventricular cardiomyopathy (HP:0011663)4.96995295
17Hyporeflexia of lower limbs (HP:0002600)4.90365192
18Syncope (HP:0001279)4.88854021
19Distal arthrogryposis (HP:0005684)4.81270760
20Myopathic facies (HP:0002058)4.65388260
21Myoglobinuria (HP:0002913)4.57203073
22Prolonged QT interval (HP:0001657)4.47941975
23* Dilated cardiomyopathy (HP:0001644)4.44555009
24Palpitations (HP:0001962)4.43171345
25EMG: myopathic abnormalities (HP:0003458)4.35747346
26Bundle branch block (HP:0011710)4.24930517
27Ventricular arrhythmia (HP:0004308)4.24370910
28Round ear (HP:0100830)4.13750043
29Asymmetric septal hypertrophy (HP:0001670)4.06058016
30Ulnar deviation of the wrist (HP:0003049)3.76428732
31Heart block (HP:0012722)3.68753945
32Ventricular fibrillation (HP:0001663)3.62975575
33Rhabdomyolysis (HP:0003201)3.59704019
34Atrioventricular block (HP:0001678)3.56527263
35Abnormal atrioventricular conduction (HP:0005150)3.47914641
36Increased connective tissue (HP:0009025)3.46468995
37Acute necrotizing encephalopathy (HP:0006965)3.23566498
38Calcaneovalgus deformity (HP:0001848)3.23419649
39Abnormal EKG (HP:0003115)3.22297015
40Abnormal mitochondria in muscle tissue (HP:0008316)3.21598714
41Type 1 muscle fiber predominance (HP:0003803)3.16362490
42Left ventricular hypertrophy (HP:0001712)3.13280069
43Myotonia (HP:0002486)3.08355425
44Frequent falls (HP:0002359)3.07116299
45Hepatic necrosis (HP:0002605)3.04750628
46Difficulty running (HP:0009046)2.98234851
47Absent phalangeal crease (HP:0006109)2.96522795
48Deformed tarsal bones (HP:0008119)2.85254209
49Distal lower limb muscle weakness (HP:0009053)2.76072694
50Malignant hyperthermia (HP:0002047)2.74594405
51Ragged-red muscle fibers (HP:0003200)2.73224762
52Neck muscle weakness (HP:0000467)2.72322677
53Acute encephalopathy (HP:0006846)2.70009435
54Bulbar palsy (HP:0001283)2.67512655
55Progressive macrocephaly (HP:0004481)2.66582968
56Hepatocellular necrosis (HP:0001404)2.66359126
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.66017078
58* Palmoplantar keratoderma (HP:0000982)2.64854410
59Mitochondrial inheritance (HP:0001427)2.63552187
60Muscle fiber inclusion bodies (HP:0100299)2.62011550
61Difficulty climbing stairs (HP:0003551)2.60933785
62Weak cry (HP:0001612)2.54739774
63Conjunctival hamartoma (HP:0100780)2.52973305
64Increased CSF lactate (HP:0002490)2.51148575
65Hypoglycemic coma (HP:0001325)2.46310678
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.44440591
67Abnormal finger flexion creases (HP:0006143)2.43332710
68Double outlet right ventricle (HP:0001719)2.40928184
69Congenital malformation of the right heart (HP:0011723)2.40928184
70Ketoacidosis (HP:0001993)2.39682809
71Exercise intolerance (HP:0003546)2.38699424
72Fetal akinesia sequence (HP:0001989)2.38457276
73Cerebral edema (HP:0002181)2.37787948
74Abnormality of the neuromuscular junction (HP:0003398)2.36691911
75Fatigable weakness (HP:0003473)2.36691911
76Areflexia of lower limbs (HP:0002522)2.35240323
77Progressive muscle weakness (HP:0003323)2.34246138
78Lower limb amyotrophy (HP:0007210)2.27205590
79Increased variability in muscle fiber diameter (HP:0003557)2.26849775
80Generalized muscle weakness (HP:0003324)2.26284593
81Increased muscle lipid content (HP:0009058)2.25713379
82Pheochromocytoma (HP:0002666)2.25126533
83Hip contracture (HP:0003273)2.22815737
84Muscle stiffness (HP:0003552)2.22778484
85Abnormality of the foot musculature (HP:0001436)2.21883709
86Mildly elevated creatine phosphokinase (HP:0008180)2.20925942
87Abnormality of skeletal muscle fiber size (HP:0012084)2.20560960
88Limb-girdle muscle atrophy (HP:0003797)2.16530641
89Neoplasm of the adrenal gland (HP:0100631)2.16328116
90Nemaline bodies (HP:0003798)2.16246418
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15226920
92Dicarboxylic aciduria (HP:0003215)2.15226920
93Abnormality of fatty-acid metabolism (HP:0004359)2.13003704
94EMG: neuropathic changes (HP:0003445)2.12796615
95Proximal amyotrophy (HP:0007126)2.11525456
96Rimmed vacuoles (HP:0003805)2.11442972
97Lactic acidosis (HP:0003128)2.10551427
98Respiratory failure (HP:0002878)2.09682600
99Sudden cardiac death (HP:0001645)2.09525143
100Congestive heart failure (HP:0001635)2.05922633
101Increased intramyocellular lipid droplets (HP:0012240)2.05186526
102Waddling gait (HP:0002515)2.05155833
103Neuroendocrine neoplasm (HP:0100634)2.04021170
104Abnormality of the shoulder girdle musculature (HP:0001435)2.02370543
105Gowers sign (HP:0003391)2.02048163
106Slender build (HP:0001533)2.01803573
107Popliteal pterygium (HP:0009756)2.01678518
108Hypoplastic left heart (HP:0004383)2.01247100
109Increased serum pyruvate (HP:0003542)2.00585095
110Abnormality of glycolysis (HP:0004366)2.00585095
111Testicular atrophy (HP:0000029)2.00190231
112Spinal rigidity (HP:0003306)1.99747408
113Hypoplastic heart (HP:0001961)1.99156295
114Foot dorsiflexor weakness (HP:0009027)1.97353335
115Respiratory insufficiency due to muscle weakness (HP:0002747)1.97219789
116Hamartoma of the eye (HP:0010568)1.92056450
117Type 2 muscle fiber atrophy (HP:0003554)1.85555859
118Scapular winging (HP:0003691)1.82220139
119Abnormality of the calcaneus (HP:0008364)1.80884927
120Muscular dystrophy (HP:0003560)1.79476996
121Hyperkalemia (HP:0002153)1.79306409
122Distal lower limb amyotrophy (HP:0008944)1.77328094
123Diaphragmatic weakness (HP:0009113)1.77081619
124Lipid accumulation in hepatocytes (HP:0006561)1.75341262
125Esophageal neoplasm (HP:0100751)1.74351276
126Neoplasm of head and neck (HP:0012288)1.74351276
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73549679
128Hyperalaninemia (HP:0003348)1.73549679
129Muscle fiber atrophy (HP:0100295)1.70862081
130Steppage gait (HP:0003376)1.69150985
131Aplasia of the musculature (HP:0100854)1.63051178
132Limb-girdle muscle weakness (HP:0003325)1.62749252
133Facial diplegia (HP:0001349)1.59910403
134Limited hip movement (HP:0008800)1.53077444
135Nonprogressive disorder (HP:0003680)1.51732974
136Abnormality of the musculature of the pelvis (HP:0001469)1.48281241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.30969558
2TTN5.15991006
3MYLK4.79685197
4LMTK23.50044752
5PKN23.37975807
6PHKG13.31805193
7PHKG23.31805193
8PDK43.07611637
9PDK33.07611637
10STK242.95734624
11DMPK2.95598424
12PIK3CA2.66232766
13MUSK2.53419617
14TRIB32.34017190
15NEK12.22533603
16BCKDK2.20631178
17TIE12.04661623
18ZAK1.91865133
19PDK21.80692230
20STK38L1.60221722
21PINK11.56322805
22ILK1.53045553
23CDC42BPA1.49259135
24PAK31.42658419
25GRK71.29555011
26CAMK2D1.24296687
27PRKD11.20871859
28MARK11.17920437
29ROCK11.14799898
30DAPK31.14215588
31STK41.13186770
32TRPM71.09557667
33FLT31.05247401
34WNK40.99390300
35MAP3K50.95744721
36MAPK120.94090269
37MOS0.91219560
38MAP3K70.86676682
39MAP2K40.81152621
40INSRR0.78759440
41PKN10.77112243
42EEF2K0.76269710
43PRKAA10.75289922
44CCNB10.72532093
45MAP2K30.71286277
46MAPKAPK30.71002753
47PRKAA20.69619055
48RIPK10.69348346
49PTK2B0.68657828
50CAMK40.66128181
51ROCK20.65154301
52MAP3K30.62880380
53CAMK2A0.62426576
54CAMK10.62176322
55MAPK40.58236118
56KDR0.57933088
57RPS6KL10.57429950
58RPS6KC10.57429950
59LIMK10.56298159
60PDGFRA0.56199407
61WNK10.55578077
62STK380.55253893
63DYRK1B0.55105847
64CAMK2B0.54446304
65MAP2K10.53859786
66MAP2K60.52628627
67PRKACB0.51529553
68RPS6KA60.48184442
69ERBB30.47362032
70KSR20.46194476
71MAP3K60.46160463
72TGFBR20.45254990
73STK390.44441136
74PRKCE0.43371637
75PRKD30.42622035
76PRKACA0.39917667
77AKT20.39176498
78MAP3K130.37404570
79EPHB20.35961907
80PIK3CG0.35729746
81NEK90.34434316
82EPHA30.33054268
83PRKACG0.32796404
84CAMK2G0.31727967
85PRKG20.29133132
86MAP3K100.28339577
87PRKG10.27113018
88ICK0.24250335
89PRKCH0.23283318
90SGK20.23083786
91MAPK100.22593852
92PDPK10.22133373
93NME20.22076081
94LATS20.21999515
95PDK10.19613144
96RPS6KB20.19546206
97PTK60.18962875
98RPS6KA10.18645480
99MARK20.18447324
100MARK30.18088328
101TBK10.18047608
102PRPF4B0.16959383
103EPHB10.16427480
104ARAF0.15693558
105ZAP700.15675337
106MAP3K10.14616721
107LATS10.13778392
108FER0.12645020
109TAOK20.12612619
110NME10.12114616
111MAPK70.11670917
112STK110.11316857
113PAK20.11133311
114RPS6KA30.10590546
115SGK30.10485622
116MAPKAPK20.10443120
117PRKCQ0.10338203
118RPS6KB10.09868855
119MTOR0.09310066
120FGFR10.09011886
121SGK10.08905565
122NLK0.08902196
123RAF10.08235435
124RPS6KA20.08091691
125LRRK20.06512301
126RET0.05704964
127UHMK10.04382049
128MAPK110.03976595
129STK30.03043984

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.02742926
2* Cardiac muscle contraction_Homo sapiens_hsa042604.87591566
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.16726043
4* Dilated cardiomyopathy_Homo sapiens_hsa054143.93765758
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.89646491
6Parkinsons disease_Homo sapiens_hsa050123.73300296
7Oxidative phosphorylation_Homo sapiens_hsa001903.63481585
8Propanoate metabolism_Homo sapiens_hsa006402.97312631
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90355588
10Alzheimers disease_Homo sapiens_hsa050102.69665873
11Fatty acid degradation_Homo sapiens_hsa000712.57536320
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54994267
13Carbon metabolism_Homo sapiens_hsa012002.54379896
14Huntingtons disease_Homo sapiens_hsa050162.41207130
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.40329712
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98025142
17Fatty acid metabolism_Homo sapiens_hsa012121.93894465
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83865355
19Pyruvate metabolism_Homo sapiens_hsa006201.75366409
20Viral myocarditis_Homo sapiens_hsa054161.69232123
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51524473
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43401093
23Biosynthesis of amino acids_Homo sapiens_hsa012301.27334659
24Fatty acid elongation_Homo sapiens_hsa000621.22604281
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15886128
26Butanoate metabolism_Homo sapiens_hsa006501.11701522
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09036302
28Glucagon signaling pathway_Homo sapiens_hsa049220.99639124
29Starch and sucrose metabolism_Homo sapiens_hsa005000.95736710
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92517162
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89910764
32Insulin resistance_Homo sapiens_hsa049310.89490060
33HIF-1 signaling pathway_Homo sapiens_hsa040660.85953745
34PPAR signaling pathway_Homo sapiens_hsa033200.83232806
35Focal adhesion_Homo sapiens_hsa045100.77754022
36Insulin signaling pathway_Homo sapiens_hsa049100.75805261
37Tight junction_Homo sapiens_hsa045300.75638071
38Adipocytokine signaling pathway_Homo sapiens_hsa049200.74581942
39Galactose metabolism_Homo sapiens_hsa000520.72905225
40Lysine degradation_Homo sapiens_hsa003100.65306768
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64628141
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.64197626
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63666413
44Tryptophan metabolism_Homo sapiens_hsa003800.63588549
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.63175398
46Oxytocin signaling pathway_Homo sapiens_hsa049210.62006562
47Phenylalanine metabolism_Homo sapiens_hsa003600.58020895
48beta-Alanine metabolism_Homo sapiens_hsa004100.57835742
49Fructose and mannose metabolism_Homo sapiens_hsa000510.57542619
50* Calcium signaling pathway_Homo sapiens_hsa040200.57520726
51AMPK signaling pathway_Homo sapiens_hsa041520.52412613
52Type II diabetes mellitus_Homo sapiens_hsa049300.48966397
53Arginine and proline metabolism_Homo sapiens_hsa003300.48733906
54Long-term potentiation_Homo sapiens_hsa047200.48536639
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47962198
56ECM-receptor interaction_Homo sapiens_hsa045120.46014469
57Nitrogen metabolism_Homo sapiens_hsa009100.45407152
58Arginine biosynthesis_Homo sapiens_hsa002200.45048696
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43193684
60Adherens junction_Homo sapiens_hsa045200.41644820
61Peroxisome_Homo sapiens_hsa041460.37375863
62Salivary secretion_Homo sapiens_hsa049700.37206094
63cAMP signaling pathway_Homo sapiens_hsa040240.36075935
64Renin secretion_Homo sapiens_hsa049240.33112242
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32237506
66Metabolic pathways_Homo sapiens_hsa011000.29548470
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28872885
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28837033
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.28228814
70Insulin secretion_Homo sapiens_hsa049110.27735475
71Bile secretion_Homo sapiens_hsa049760.26413820
72Amoebiasis_Homo sapiens_hsa051460.26040933
73Fatty acid biosynthesis_Homo sapiens_hsa000610.25752635
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24020347
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23684060
76Circadian entrainment_Homo sapiens_hsa047130.23161008
77Tyrosine metabolism_Homo sapiens_hsa003500.22604194
78Proteoglycans in cancer_Homo sapiens_hsa052050.21804715
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21353980
80Regulation of autophagy_Homo sapiens_hsa041400.21333754
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.20813296
82Amphetamine addiction_Homo sapiens_hsa050310.20606179
83Gastric acid secretion_Homo sapiens_hsa049710.20070906
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19468721
85Sulfur relay system_Homo sapiens_hsa041220.16222994
86Circadian rhythm_Homo sapiens_hsa047100.16000263
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14254196
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09389077
89Ovarian steroidogenesis_Homo sapiens_hsa049130.08804660
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07203396
91Platelet activation_Homo sapiens_hsa046110.07107655
92Histidine metabolism_Homo sapiens_hsa003400.06547373
93Long-term depression_Homo sapiens_hsa047300.05849149
94Renal cell carcinoma_Homo sapiens_hsa052110.05583013
95Endometrial cancer_Homo sapiens_hsa052130.04513806
96Gap junction_Homo sapiens_hsa045400.03467354
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01857955
98Cholinergic synapse_Homo sapiens_hsa047250.01073212
99mTOR signaling pathway_Homo sapiens_hsa041500.01028127
100GnRH signaling pathway_Homo sapiens_hsa049120.00540622
101Pentose phosphate pathway_Homo sapiens_hsa000300.00188195
102Small cell lung cancer_Homo sapiens_hsa052220.00053266
103MAPK signaling pathway_Homo sapiens_hsa04010-0.0685914
104Toxoplasmosis_Homo sapiens_hsa05145-0.0422983
105VEGF signaling pathway_Homo sapiens_hsa04370-0.0413344
106Pancreatic secretion_Homo sapiens_hsa04972-0.0408163
107Notch signaling pathway_Homo sapiens_hsa04330-0.0372576
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0366640
109Olfactory transduction_Homo sapiens_hsa04740-0.0175552
110Taste transduction_Homo sapiens_hsa04742-0.0173929
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0092907
112PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0069192
113Melanogenesis_Homo sapiens_hsa04916-0.0034562
114Fat digestion and absorption_Homo sapiens_hsa04975-0.0026127
115FoxO signaling pathway_Homo sapiens_hsa04068-0.0002122

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