TNNI3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)8.68565157
2sarcomere organization (GO:0045214)8.25905411
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.15733167
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.65548969
5tricarboxylic acid cycle (GO:0006099)7.36617793
6negative regulation of potassium ion transmembrane transport (GO:1901380)7.26052869
7myofibril assembly (GO:0030239)7.18634605
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.93862047
9regulation of relaxation of muscle (GO:1901077)6.77769806
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.76467028
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.75297265
12cardiac muscle contraction (GO:0060048)6.66294011
13cardiac muscle cell development (GO:0055013)6.28892233
14regulation of sarcomere organization (GO:0060297)6.26603787
15regulation of actin filament-based movement (GO:1903115)6.21232549
16bundle of His cell to Purkinje myocyte communication (GO:0086069)6.08753515
17regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.93119965
18cardiac cell development (GO:0055006)5.89529779
19cardiac muscle hypertrophy (GO:0003300)5.84062855
20ventricular cardiac muscle cell action potential (GO:0086005)5.83551312
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60658387
22cardiac muscle tissue morphogenesis (GO:0055008)5.52901266
23striated muscle hypertrophy (GO:0014897)5.50622056
24heart trabecula formation (GO:0060347)5.46484134
25muscle filament sliding (GO:0030049)5.45330434
26actin-myosin filament sliding (GO:0033275)5.45330434
27regulation of acyl-CoA biosynthetic process (GO:0050812)5.42393105
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42240098
29regulation of cell communication by electrical coupling (GO:0010649)5.38104169
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.33933942
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.33404912
32energy coupled proton transport, down electrochemical gradient (GO:0015985)5.32195526
33ATP synthesis coupled proton transport (GO:0015986)5.32195526
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.31370766
35cardiac chamber formation (GO:0003207)5.26677659
36actomyosin structure organization (GO:0031032)5.21012895
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.20675782
38respiratory electron transport chain (GO:0022904)5.16723643
39cell communication involved in cardiac conduction (GO:0086065)5.15108433
40carnitine shuttle (GO:0006853)5.12433856
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.07235259
42electron transport chain (GO:0022900)5.01371746
43adult heart development (GO:0007512)4.99775514
44regulation of cofactor metabolic process (GO:0051193)4.97679735
45regulation of coenzyme metabolic process (GO:0051196)4.97679735
46regulation of striated muscle contraction (GO:0006942)4.96272363
47regulation of the force of heart contraction (GO:0002026)4.93266170
48muscle tissue morphogenesis (GO:0060415)4.89813963
49heart contraction (GO:0060047)4.88397764
50heart process (GO:0003015)4.88397764
51muscle hypertrophy (GO:0014896)4.88148044
52sarcoplasmic reticulum calcium ion transport (GO:0070296)4.85884272
53relaxation of cardiac muscle (GO:0055119)4.80123861
54regulation of cardiac muscle cell contraction (GO:0086004)4.78007458
55oxidative phosphorylation (GO:0006119)4.76942676
56regulation of membrane repolarization (GO:0060306)4.75993369
57adrenergic receptor signaling pathway (GO:0071875)4.72816898
58cardiac ventricle formation (GO:0003211)4.71043425
59striated muscle contraction (GO:0006941)4.69550678
60cell communication by electrical coupling (GO:0010644)4.59149572
61fatty acid transmembrane transport (GO:1902001)4.59125107
62plasma membrane repair (GO:0001778)4.58592455
63actin-mediated cell contraction (GO:0070252)4.56167798
64regulation of skeletal muscle contraction (GO:0014819)4.52395955
65regulation of cardiac muscle contraction (GO:0055117)4.52376045
66response to caffeine (GO:0031000)4.39066234
67cellular response to epinephrine stimulus (GO:0071872)4.27772502
68ventricular cardiac muscle cell development (GO:0055015)4.23632349
69neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.15200345
70cardiac muscle cell action potential (GO:0086001)4.12993445
71response to epinephrine (GO:0071871)4.12265992
72regulation of heart rate (GO:0002027)4.11155772
73cardiac muscle cell action potential involved in contraction (GO:0086002)4.10882485
742-oxoglutarate metabolic process (GO:0006103)4.07717890
75cardiac muscle adaptation (GO:0014887)4.07597860
76cardiac muscle hypertrophy in response to stress (GO:0014898)4.07597860
77muscle hypertrophy in response to stress (GO:0003299)4.07597860
78regulation of sulfur metabolic process (GO:0042762)4.04016348
79cardiac conduction (GO:0061337)3.97721096
80relaxation of muscle (GO:0090075)3.95875393
81NADH metabolic process (GO:0006734)3.95443950
82positive regulation of action potential (GO:0045760)3.95319719
83negative regulation of potassium ion transport (GO:0043267)3.94405915
84positive regulation of ATP catabolic process (GO:1903291)3.91082940
85positive regulation of ATPase activity (GO:0032781)3.91082940
86carnitine transmembrane transport (GO:1902603)3.80074312
87creatine metabolic process (GO:0006600)3.79731626
88detection of calcium ion (GO:0005513)3.76491714
89negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.75379803
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74581276
91succinate metabolic process (GO:0006105)3.73553879
92cardiac muscle tissue development (GO:0048738)3.71417773
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.69927359
94response to inactivity (GO:0014854)3.69328433
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.67790500
96regulation of heart contraction (GO:0008016)3.67530940
97regulation of ATPase activity (GO:0043462)3.67321237
98regulation of ATP catabolic process (GO:1903289)3.67321237
99regulation of muscle contraction (GO:0006937)3.66765115
100atrial septum morphogenesis (GO:0060413)3.66683768
101negative regulation of heart rate (GO:0010459)3.64015630
102regulation of sequestering of triglyceride (GO:0010889)3.62539681
103fatty acid beta-oxidation (GO:0006635)3.61916780
104regulation of heart rate by cardiac conduction (GO:0086091)3.60824008
105negative regulation of calcium ion transmembrane transport (GO:1903170)3.52321413
106negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.52321413
107positive regulation of heart contraction (GO:0045823)3.51988853
108ATP biosynthetic process (GO:0006754)3.49786985
109positive regulation of heart rate (GO:0010460)3.49523318
110regulation of cardioblast differentiation (GO:0051890)3.46329076
111negative regulation of striated muscle cell apoptotic process (GO:0010664)3.45972695
112amino-acid betaine transport (GO:0015838)3.45314681
113carnitine transport (GO:0015879)3.45314681
114trabecula formation (GO:0060343)3.43351632
115actin filament-based movement (GO:0030048)3.40016990
116regulation of calcium ion transmembrane transporter activity (GO:1901019)3.38129601
117regulation of calcium ion transmembrane transport (GO:1903169)3.38129601
118negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.35918730
119aspartate family amino acid catabolic process (GO:0009068)3.35605739
120positive regulation of sodium ion transport (GO:0010765)3.35269193
121calcium-mediated signaling using intracellular calcium source (GO:0035584)3.34627051
122muscle contraction (GO:0006936)3.34376041
123regulation of muscle system process (GO:0090257)3.31685619
124striated muscle cell development (GO:0055002)3.31291354
125regulation of cation channel activity (GO:2001257)3.29725452
126relaxation of smooth muscle (GO:0044557)3.27952473
127striated muscle adaptation (GO:0014888)3.24691552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.72577621
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.70837471
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.38265152
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.50033382
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.22628454
6TBX20_22328084_ChIP-Seq_HEART_Mouse4.22628454
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90854153
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.39278450
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.21898974
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.97494232
11ZNF263_19887448_ChIP-Seq_K562_Human2.83400339
12GATA4_21415370_ChIP-Seq_HL-1_Mouse2.69884124
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63692197
14GBX2_23144817_ChIP-Seq_PC3_Human2.44053107
15GATA1_22025678_ChIP-Seq_K562_Human2.29654229
16EZH2_22144423_ChIP-Seq_EOC_Human2.22751248
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09011347
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.04233138
19NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.01436856
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00655599
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94371332
22CLOCK_20551151_ChIP-Seq_293T_Human1.92882811
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.91947479
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90021644
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82132620
26TAF15_26573619_Chip-Seq_HEK293_Human1.79352597
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.75992679
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74919372
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74325957
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.72330511
31* VDR_22108803_ChIP-Seq_LS180_Human1.69241535
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64864652
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64787287
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63989945
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57409958
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56358791
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54061277
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51844448
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50295821
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45538818
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44536518
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.43865810
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42494614
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40385976
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.40140821
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38651233
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37037687
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33885682
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33885682
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.33557898
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31360427
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.29795029
53ZNF274_21170338_ChIP-Seq_K562_Hela1.29733508
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29459202
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29031549
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28544099
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26792709
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.25044132
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.24790632
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23447977
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.22337055
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22330567
63BCAT_22108803_ChIP-Seq_LS180_Human1.21970231
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21937203
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21450815
66* TCF4_23295773_ChIP-Seq_U87_Human1.20468978
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.19395406
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18527120
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17892738
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16985514
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15958878
72IGF1R_20145208_ChIP-Seq_DFB_Human1.14798733
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.13443660
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.11972504
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11782888
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11322188
77* STAT3_23295773_ChIP-Seq_U87_Human1.10955982
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07936609
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.07462985
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07256444
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06812371
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06654254
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06440697
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06259513
85CJUN_26792858_Chip-Seq_BT549_Human1.06247505
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05851441
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05062324
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.05026028
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03542222
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02469092
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02451113
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.01705950
93HTT_18923047_ChIP-ChIP_STHdh_Human1.01435763
94* TBL1_22424771_ChIP-Seq_293T_Human1.00435104
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.00335801
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99189630
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98960208
98* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98800341
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98673282
100P300_19829295_ChIP-Seq_ESCs_Human0.98553772
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97705618
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97095574
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.96636775
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96164906
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96164906
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95309902
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94695771
108STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94634003
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94010715
110RXR_22158963_ChIP-Seq_LIVER_Mouse0.93961963
111* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93546277
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93151932
113GATA1_19941826_ChIP-Seq_K562_Human0.92665508
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91396564
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.88424639
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88313592
117DROSHA_22980978_ChIP-Seq_HELA_Human0.86853737
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86364480
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86274002
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.82784890
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82473723
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82355345
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.82213147
124TP63_22573176_ChIP-Seq_HFKS_Human0.78385772
125RUNX1_27514584_Chip-Seq_MCF-7_Human0.78004522
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77951749
127SPI1_20517297_ChIP-Seq_HL60_Human0.77315717
128ATF3_27146783_Chip-Seq_COLON_Human0.76978307
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75724065
130CTCF_27219007_Chip-Seq_Bcells_Human0.75352714
131GATA2_19941826_ChIP-Seq_K562_Human0.75197387
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75159671
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.74929664
134EGR1_19032775_ChIP-ChIP_M12_Human0.74731341
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.73767120
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72191822
137FOXH1_21741376_ChIP-Seq_ESCs_Human0.72160891
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70650321
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70525499
140GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69381516
141TP53_16413492_ChIP-PET_HCT116_Human0.69248751
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69054953
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68982862
144SMC3_22415368_ChIP-Seq_MEFs_Mouse0.68760588
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67767482
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67714779
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67407950
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.65984246
149TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65929595
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.64808427
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64686555
152* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.64237541
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64106788
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.63510542
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63476172
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.63359954
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.63041914
158OCT4_20526341_ChIP-Seq_ESCs_Human0.62420107
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.60225052
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.60031542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.25686297
2MP0002837_dystrophic_cardiac_calcinosis6.19830722
3MP0004215_abnormal_myocardial_fiber5.27757327
4MP0003646_muscle_fatigue5.15561021
5MP0000751_myopathy4.82509191
6MP0005330_cardiomyopathy4.28441269
7MP0004036_abnormal_muscle_relaxation4.22890094
8MP0000749_muscle_degeneration3.54318221
9MP0008775_abnormal_heart_ventricle3.46890897
10MP0002972_abnormal_cardiac_muscle3.40604670
11MP0004484_altered_response_of3.10452790
12MP0003137_abnormal_impulse_conducting3.08536067
13MP0004087_abnormal_muscle_fiber3.01074887
14MP0001544_abnormal_cardiovascular_syste2.84466722
15MP0005385_cardiovascular_system_phenoty2.84466722
16MP0010630_abnormal_cardiac_muscle2.79375536
17MP0004130_abnormal_muscle_cell2.77411163
18MP0005620_abnormal_muscle_contractility2.67250210
19MP0000750_abnormal_muscle_regeneration2.54979692
20MP0006138_congestive_heart_failure2.48626917
21MP0003828_pulmonary_edema2.47257361
22MP0004085_abnormal_heartbeat2.34756936
23MP0004510_myositis2.32380269
24MP0002106_abnormal_muscle_physiology2.29770390
25MP0003221_abnormal_cardiomyocyte_apopto2.20884883
26MP0002269_muscular_atrophy2.05808692
27MP0006036_abnormal_mitochondrial_physio2.00356096
28MP0002127_abnormal_cardiovascular_syste1.87534318
29MP0005369_muscle_phenotype1.81964300
30MP0004145_abnormal_muscle_electrophysio1.71859492
31MP0003950_abnormal_plasma_membrane1.68326713
32MP0000759_abnormal_skeletal_muscle1.66470191
33MP0000747_muscle_weakness1.64616866
34MP0004233_abnormal_muscle_weight1.52387857
35MP0002332_abnormal_exercise_endurance1.50207031
36MP0003567_abnormal_fetal_cardiomyocyte1.47234803
37MP0005165_increased_susceptibility_to1.39537433
38MP0000343_altered_response_to1.30111956
39MP0005666_abnormal_adipose_tissue1.27570107
40MP0006035_abnormal_mitochondrial_morpho1.23381575
41MP0000266_abnormal_heart_morphology1.22505990
42MP0010368_abnormal_lymphatic_system1.13111554
43MP0003279_aneurysm1.01803923
44MP0005670_abnormal_white_adipose1.00292694
45MP0000230_abnormal_systemic_arterial0.90989877
46MP0002234_abnormal_pharynx_morphology0.89456033
47MP0008004_abnormal_stomach_pH0.88057791
48MP0001984_abnormal_olfaction0.87053955
49MP0004043_abnormal_pH_regulation0.84982441
50MP0005266_abnormal_metabolism0.84655167
51MP0005375_adipose_tissue_phenotype0.83250016
52MP0003566_abnormal_cell_adhesion0.82351215
53MP0002128_abnormal_blood_circulation0.81693972
54MP0005623_abnormal_meninges_morphology0.79826441
55MP0004185_abnormal_adipocyte_glucose0.79295894
56MP0001661_extended_life_span0.72815203
57MP0009745_abnormal_behavioral_response0.67412070
58MP0002108_abnormal_muscle_morphology0.66517095
59MP0001879_abnormal_lymphatic_vessel0.65727929
60MP0008569_lethality_at_weaning0.64765447
61MP0005451_abnormal_body_composition0.61120932
62MP0004147_increased_porphyrin_level0.60864095
63MP0002735_abnormal_chemical_nociception0.60438040
64MP0003880_abnormal_central_pattern0.58994098
65MP0003806_abnormal_nucleotide_metabolis0.58136664
66MP0004272_abnormal_basement_membrane0.57880587
67MP0009384_cardiac_valve_regurgitation0.54992158
68MP0002272_abnormal_nervous_system0.54981198
69MP0000003_abnormal_adipose_tissue0.54800645
70MP0000767_abnormal_smooth_muscle0.54338628
71MP0000013_abnormal_adipose_tissue0.53951241
72MP0002909_abnormal_adrenal_gland0.53592251
73MP0002078_abnormal_glucose_homeostasis0.49373493
74MP0005503_abnormal_tendon_morphology0.48846409
75MP0005319_abnormal_enzyme/_coenzyme0.48715273
76MP0005187_abnormal_penis_morphology0.48051782
77MP0003787_abnormal_imprinting0.45985750
78MP0002971_abnormal_brown_adipose0.45310110
79MP0006072_abnormal_retinal_apoptosis0.45178291
80MP0001486_abnormal_startle_reflex0.44781716
81MP0008438_abnormal_cutaneous_collagen0.43868101
82MP0002925_abnormal_cardiovascular_devel0.43721207
83MP0003705_abnormal_hypodermis_morpholog0.42217522
84MP0003984_embryonic_growth_retardation0.41872465
85MP0005535_abnormal_body_temperature0.41595125
86MP0002088_abnormal_embryonic_growth/wei0.41121937
87MP0002064_seizures0.41071764
88MP0003195_calcinosis0.41000627
89MP0002638_abnormal_pupillary_reflex0.40455147
90MP0005085_abnormal_gallbladder_physiolo0.39376482
91MP0005386_behavior/neurological_phenoty0.38634354
92MP0004924_abnormal_behavior0.38634354
93MP0004859_abnormal_synaptic_plasticity0.38005108
94MP0001614_abnormal_blood_vessel0.36890227
95MP0002822_catalepsy0.36454699
96MP0003635_abnormal_synaptic_transmissio0.35961414
97MP0003136_yellow_coat_color0.35681566
98MP0005275_abnormal_skin_tensile0.35323691
99MP0002063_abnormal_learning/memory/cond0.35302646
100MP0000733_abnormal_muscle_development0.35103259
101MP0006276_abnormal_autonomic_nervous0.34403323
102MP0002877_abnormal_melanocyte_morpholog0.34000163
103MP0001784_abnormal_fluid_regulation0.33884229
104MP0005248_abnormal_Harderian_gland0.33522839
105MP0005595_abnormal_vascular_smooth0.32168819
106MP0005332_abnormal_amino_acid0.32165936
107MP0005423_abnormal_somatic_nervous0.32113338
108MP0001440_abnormal_grooming_behavior0.31935850
109MP0002572_abnormal_emotion/affect_behav0.31739890
110MP0001727_abnormal_embryo_implantation0.30841248
111MP0001970_abnormal_pain_threshold0.30265902
112MP0008961_abnormal_basal_metabolism0.29622124
113MP0002295_abnormal_pulmonary_circulatio0.29005071
114MP0002090_abnormal_vision0.28274059
115MP0005584_abnormal_enzyme/coenzyme_acti0.27705067
116MP0001986_abnormal_taste_sensitivity0.26996390
117MP0003948_abnormal_gas_homeostasis0.26411311
118MP0002118_abnormal_lipid_homeostasis0.26319512
119MP0009046_muscle_twitch0.25671798
120MP0005167_abnormal_blood-brain_barrier0.25597226
121MP0005388_respiratory_system_phenotype0.25113592
122MP0002133_abnormal_respiratory_system0.25113592
123MP0005253_abnormal_eye_physiology0.24638734
124MP0002102_abnormal_ear_morphology0.24173029
125MP0001299_abnormal_eye_distance/0.23979057
126MP0000249_abnormal_blood_vessel0.23076485
127MP0001529_abnormal_vocalization0.22173208
128MP0009780_abnormal_chondrocyte_physiolo0.21752796
129MP0003045_fibrosis0.21652802
130MP0005334_abnormal_fat_pad0.19381398

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.11714032
2Ventricular tachycardia (HP:0004756)7.14149848
3Atrial fibrillation (HP:0005110)6.50777874
4Primary atrial arrhythmia (HP:0001692)6.08086128
5Supraventricular tachycardia (HP:0004755)5.87898473
6Supraventricular arrhythmia (HP:0005115)5.74769283
7Calf muscle hypertrophy (HP:0008981)5.53500454
8Syncope (HP:0001279)5.47455852
9Right ventricular cardiomyopathy (HP:0011663)5.37099707
10Lipoatrophy (HP:0100578)5.32578495
11Abnormality of the calf musculature (HP:0001430)4.94754000
12Muscle hypertrophy of the lower extremities (HP:0008968)4.94126310
13Exercise-induced muscle cramps (HP:0003710)4.93919439
14Bundle branch block (HP:0011710)4.92963039
15Palpitations (HP:0001962)4.84807995
16Myoglobinuria (HP:0002913)4.77889222
17Exercise-induced myalgia (HP:0003738)4.77024538
18Muscle fiber splitting (HP:0003555)4.43647408
19Dilated cardiomyopathy (HP:0001644)4.43443478
20Prolonged QT interval (HP:0001657)4.39907911
21Ventricular arrhythmia (HP:0004308)4.33067425
22Abnormality of the left ventricular outflow tract (HP:0011103)4.20544950
23Subaortic stenosis (HP:0001682)4.20544950
24Abnormal mitochondria in muscle tissue (HP:0008316)4.19665979
25Acute necrotizing encephalopathy (HP:0006965)4.17878139
26Hyporeflexia of lower limbs (HP:0002600)4.16180343
27Heart block (HP:0012722)3.99465719
28EMG: neuropathic changes (HP:0003445)3.89091854
29Asymmetric septal hypertrophy (HP:0001670)3.88446608
30Hepatic necrosis (HP:0002605)3.78027129
31Abnormal atrioventricular conduction (HP:0005150)3.77533693
32Ventricular fibrillation (HP:0001663)3.67162956
33Atrioventricular block (HP:0001678)3.66036890
34Acute encephalopathy (HP:0006846)3.59318774
35Progressive macrocephaly (HP:0004481)3.53197962
36Rhabdomyolysis (HP:0003201)3.49712553
37EMG: myopathic abnormalities (HP:0003458)3.45042170
38Hypoglycemic coma (HP:0001325)3.44859799
39Hepatocellular necrosis (HP:0001404)3.21865131
40Ketoacidosis (HP:0001993)3.21740394
41Bradycardia (HP:0001662)3.21173827
42Cerebral edema (HP:0002181)3.20717224
43Mitochondrial inheritance (HP:0001427)3.17574961
44Abnormal EKG (HP:0003115)3.13328665
45Centrally nucleated skeletal muscle fibers (HP:0003687)3.09803413
46Left ventricular hypertrophy (HP:0001712)3.04937819
47Increased CSF lactate (HP:0002490)3.03644091
48Congenital malformation of the right heart (HP:0011723)3.00881998
49Double outlet right ventricle (HP:0001719)3.00881998
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.98123877
51Dicarboxylic aciduria (HP:0003215)2.98123877
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93799732
53Abnormality of alanine metabolism (HP:0010916)2.93799732
54Hyperalaninemia (HP:0003348)2.93799732
55Conjunctival hamartoma (HP:0100780)2.91007232
56Rimmed vacuoles (HP:0003805)2.84928060
57Increased connective tissue (HP:0009025)2.82953628
58Ragged-red muscle fibers (HP:0003200)2.82229025
59Hypoplastic left heart (HP:0004383)2.82184837
60Abnormality of fatty-acid metabolism (HP:0004359)2.80663401
61Palmoplantar keratoderma (HP:0000982)2.69656608
62Pheochromocytoma (HP:0002666)2.68321029
63Type 1 muscle fiber predominance (HP:0003803)2.67989063
64Lactic acidosis (HP:0003128)2.65897646
65Myotonia (HP:0002486)2.61548005
66Respiratory failure (HP:0002878)2.61046541
67Exercise intolerance (HP:0003546)2.56266543
68Difficulty running (HP:0009046)2.55727326
69Increased muscle lipid content (HP:0009058)2.54191703
70Neoplasm of the adrenal gland (HP:0100631)2.51924779
71Neuroendocrine neoplasm (HP:0100634)2.41942549
72Distal lower limb muscle weakness (HP:0009053)2.41405972
73Myokymia (HP:0002411)2.40247093
74Abnormality of glycolysis (HP:0004366)2.37064171
75Increased serum pyruvate (HP:0003542)2.37064171
76Sudden cardiac death (HP:0001645)2.35267830
77Increased intramyocellular lipid droplets (HP:0012240)2.31967573
78Generalized muscle weakness (HP:0003324)2.26638035
79Ketosis (HP:0001946)2.26167642
80Generalized aminoaciduria (HP:0002909)2.25467879
81Difficulty climbing stairs (HP:0003551)2.21568364
82Neoplasm of head and neck (HP:0012288)2.21131718
83Esophageal neoplasm (HP:0100751)2.21131718
84Hypoplastic heart (HP:0001961)2.21051649
85Hamartoma of the eye (HP:0010568)2.15600885
86Abnormality of the tricuspid valve (HP:0001702)2.12637563
87Hyperinsulinemic hypoglycemia (HP:0000825)2.12611549
88Steppage gait (HP:0003376)2.11606379
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10385461
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10385461
91Foot dorsiflexor weakness (HP:0009027)2.07975286
92Lipid accumulation in hepatocytes (HP:0006561)2.06999118
93Areflexia of lower limbs (HP:0002522)2.06124832
94Congestive heart failure (HP:0001635)2.03858467
95Limb hypertonia (HP:0002509)1.99642891
96Muscle stiffness (HP:0003552)1.99088484
97Nausea (HP:0002018)1.96637806
98Hyperammonemia (HP:0001987)1.93131918
99Resting tremor (HP:0002322)1.92992663
100Limb-girdle muscle atrophy (HP:0003797)1.92684061
101Athetosis (HP:0002305)1.90767154
102Hypoplastic ischia (HP:0003175)1.89250688
103Hyperglycemia (HP:0003074)1.87324780
104Optic disc pallor (HP:0000543)1.86130860
105Mildly elevated creatine phosphokinase (HP:0008180)1.84719510
106Central scotoma (HP:0000603)1.84079517
107Increased variability in muscle fiber diameter (HP:0003557)1.81749453
108Multiple enchondromatosis (HP:0005701)1.80777791
109Lymphangioma (HP:0100764)1.79652702
110Large for gestational age (HP:0001520)1.78749563
111Toxemia of pregnancy (HP:0100603)1.78367156
112Increased serum lactate (HP:0002151)1.78264999
113Neck muscle weakness (HP:0000467)1.76982272
114Testicular atrophy (HP:0000029)1.76320306
115Tinnitus (HP:0000360)1.75861596
116Lethargy (HP:0001254)1.75177792
117Abnormality of the foot musculature (HP:0001436)1.73389423
118Muscular dystrophy (HP:0003560)1.66538793
119Abnormality of the endocardium (HP:0004306)1.65646677
120Skin nodule (HP:0200036)1.64829982
121Scapular winging (HP:0003691)1.61870186
122Late onset (HP:0003584)1.58285956
123Dysmetric saccades (HP:0000641)1.56936058
124Prenatal maternal abnormality (HP:0002686)1.52614751
125Frequent falls (HP:0002359)1.50244908
126Patent foramen ovale (HP:0001655)1.49467746
127Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.48016882
128Childhood onset (HP:0011463)1.47724016
129Abnormality of the shoulder girdle musculature (HP:0001435)1.44338526
130Abnormality of skeletal muscle fiber size (HP:0012084)1.39796353
131Periauricular skin pits (HP:0100277)1.35167973
132Preauricular pit (HP:0004467)1.35167973
133Muscle fiber inclusion bodies (HP:0100299)1.33737626
134Pulmonary artery stenosis (HP:0004415)1.32292047
135Anomalous pulmonary venous return (HP:0010772)1.32112742
136Transposition of the great arteries (HP:0001669)1.31509531
137Abnormal connection of the cardiac segments (HP:0011545)1.31509531
138Abnormal ventriculo-arterial connection (HP:0011563)1.31509531
139Maternal diabetes (HP:0009800)1.31251625
140Skin pits (HP:0100276)1.30372233
141Proximal amyotrophy (HP:0007126)1.30095932
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.27327323
143Distal lower limb amyotrophy (HP:0008944)1.26959472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.34071225
2LMTK24.14517038
3PDK44.13623097
4PDK34.13623097
5MYLK3.93398069
6OBSCN3.75382864
7PKN23.73111412
8PHKG23.51111102
9PHKG13.51111102
10DMPK2.86072257
11STK242.67835168
12TRIB32.54997868
13PDK22.54802809
14BCKDK2.39208740
15GRK72.24008037
16NEK12.15226958
17TIE12.11137863
18PIK3CA2.10853646
19MUSK2.09012742
20PINK12.02878529
21MARK12.02603106
22CAMK2D1.53494803
23PAK31.49449011
24NME21.38230690
25ILK1.34605740
26PRKD11.33176070
27WNK41.25435716
28INSRR1.22951560
29STK38L1.22557403
30FLT31.20722782
31TRPM71.09352922
32ZAK1.09239715
33CDC42BPA1.09173301
34STK41.06210329
35CAMK41.03229618
36ROCK10.95502417
37MAP3K60.92251563
38MAP3K70.90824410
39EPHA40.86674767
40PRKAA20.85073907
41PRKAA10.85043194
42MAPK120.84816422
43DAPK30.82143166
44CAMK2A0.78171372
45STK380.76647016
46STK390.76480171
47MAP3K50.75867340
48EPHA30.75473053
49CAMK10.71255481
50WNK10.70581502
51NEK90.70062304
52MAP4K20.67017071
53PDGFRA0.65748827
54AKT30.65489049
55KDR0.65437612
56RIPK10.63846573
57PKN10.63714894
58MAPKAPK30.63586417
59ROCK20.53185223
60NTRK20.51378172
61WNK30.51038510
62MAP3K30.50638673
63PTK2B0.49886366
64MAP3K120.49853896
65NTRK30.49567158
66FRK0.49205503
67PLK20.48901457
68PRKCE0.48674094
69ITK0.48235556
70CAMK2G0.47109926
71PRKACB0.45940884
72MAPK130.44429837
73PRKACG0.44221428
74TGFBR20.43067034
75PRKACA0.42873109
76MAP2K30.42862560
77RPS6KC10.42446276
78RPS6KL10.42446276
79MAPK40.41596244
80LIMK10.41481853
81PDK10.40923394
82CDK50.40700594
83PDPK10.39490592
84TNIK0.38385821
85RPS6KA60.33987927
86STK110.33290697
87MAP2K10.32772278
88RET0.32032036
89LATS20.32010054
90SGK20.30701658
91PAK60.30135015
92AKT20.29972742
93LATS10.28358232
94SGK4940.27948184
95SGK2230.27948184
96RPS6KA10.25532674
97CASK0.24073748
98PRKG20.23727839
99PTK60.23413481
100PRKCH0.22349019
101PRKCQ0.21657470
102JAK10.21000510
103LRRK20.18991779
104UHMK10.17719374
105ADRBK10.17241666
106MARK30.16992009
107PRKCA0.16636285
108BMPR1B0.16252509
109PRKD30.15960333
110DAPK20.15139144
111PRKG10.15054508
112FER0.14697419
113SGK10.14372272
114PRKCB0.12923567
115CAMK2B0.12321561
116MAP3K40.10872824
117EPHB10.09919471
118MAPK70.09747089
119PDGFRB0.09607807
120RPS6KA30.09509176
121ICK0.08497182
122SGK30.08035329
123MAP2K40.07673383
124MAPK110.07252650
125MTOR0.06821503
126SIK10.05100571
127JAK20.04995491
128EPHB20.04126268

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.29050385
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.12858466
3Cardiac muscle contraction_Homo sapiens_hsa042604.08039081
4Parkinsons disease_Homo sapiens_hsa050123.74736306
5Oxidative phosphorylation_Homo sapiens_hsa001903.72052105
6Propanoate metabolism_Homo sapiens_hsa006403.58355829
7Dilated cardiomyopathy_Homo sapiens_hsa054143.36532428
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.20494817
9Fatty acid degradation_Homo sapiens_hsa000713.14686059
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98722560
11Alzheimers disease_Homo sapiens_hsa050102.76566757
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67327715
13Carbon metabolism_Homo sapiens_hsa012002.52790240
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49689965
15Huntingtons disease_Homo sapiens_hsa050162.40428697
16Fatty acid metabolism_Homo sapiens_hsa012122.37095421
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24934154
18Pyruvate metabolism_Homo sapiens_hsa006201.92430527
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67828725
20Butanoate metabolism_Homo sapiens_hsa006501.60726936
21Fatty acid elongation_Homo sapiens_hsa000621.54696572
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52038767
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47058613
24Viral myocarditis_Homo sapiens_hsa054161.45246306
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22460028
26Morphine addiction_Homo sapiens_hsa050321.08834479
27Amphetamine addiction_Homo sapiens_hsa050311.02047116
28GABAergic synapse_Homo sapiens_hsa047271.00517706
29Biosynthesis of amino acids_Homo sapiens_hsa012300.98074732
30PPAR signaling pathway_Homo sapiens_hsa033200.97229541
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95093277
32cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93028967
33Insulin resistance_Homo sapiens_hsa049310.90033394
34Cocaine addiction_Homo sapiens_hsa050300.88560214
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88109247
36Adipocytokine signaling pathway_Homo sapiens_hsa049200.83833562
37Tryptophan metabolism_Homo sapiens_hsa003800.82860346
38Glucagon signaling pathway_Homo sapiens_hsa049220.82740747
39beta-Alanine metabolism_Homo sapiens_hsa004100.79164167
40Starch and sucrose metabolism_Homo sapiens_hsa005000.79062819
41Regulation of autophagy_Homo sapiens_hsa041400.75917208
42Salivary secretion_Homo sapiens_hsa049700.72179820
43Peroxisome_Homo sapiens_hsa041460.71438266
44Calcium signaling pathway_Homo sapiens_hsa040200.68668683
45Insulin signaling pathway_Homo sapiens_hsa049100.68654638
46HIF-1 signaling pathway_Homo sapiens_hsa040660.66958894
47Glutamatergic synapse_Homo sapiens_hsa047240.66466877
48Dopaminergic synapse_Homo sapiens_hsa047280.65883300
49Lysine degradation_Homo sapiens_hsa003100.65253405
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65214084
51Arginine and proline metabolism_Homo sapiens_hsa003300.61494656
52Arginine biosynthesis_Homo sapiens_hsa002200.60883426
53Focal adhesion_Homo sapiens_hsa045100.55433449
54Serotonergic synapse_Homo sapiens_hsa047260.54927278
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54350122
56AMPK signaling pathway_Homo sapiens_hsa041520.52272782
57Oxytocin signaling pathway_Homo sapiens_hsa049210.51272451
58Type II diabetes mellitus_Homo sapiens_hsa049300.48655049
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.48518255
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46706342
61Long-term potentiation_Homo sapiens_hsa047200.45098240
62Fatty acid biosynthesis_Homo sapiens_hsa000610.41526795
63Galactose metabolism_Homo sapiens_hsa000520.40651371
64cAMP signaling pathway_Homo sapiens_hsa040240.40647897
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.40513514
66Nicotine addiction_Homo sapiens_hsa050330.39644278
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39500740
68Phenylalanine metabolism_Homo sapiens_hsa003600.38657007
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37292518
70Mineral absorption_Homo sapiens_hsa049780.37153131
71Melanogenesis_Homo sapiens_hsa049160.36935574
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36619951
73Renin secretion_Homo sapiens_hsa049240.35828392
74Linoleic acid metabolism_Homo sapiens_hsa005910.35424259
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34747659
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34402698
77ECM-receptor interaction_Homo sapiens_hsa045120.33827897
78Metabolic pathways_Homo sapiens_hsa011000.33309256
79Thyroid hormone synthesis_Homo sapiens_hsa049180.32612037
80Gastric acid secretion_Homo sapiens_hsa049710.32362963
81Sulfur relay system_Homo sapiens_hsa041220.29929441
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28407685
83Tight junction_Homo sapiens_hsa045300.28206867
84Insulin secretion_Homo sapiens_hsa049110.27975658
85Circadian entrainment_Homo sapiens_hsa047130.23393143
86Fructose and mannose metabolism_Homo sapiens_hsa000510.23256553
87Adherens junction_Homo sapiens_hsa045200.21134148
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20721328
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.18629583
90ABC transporters_Homo sapiens_hsa020100.17802316
91Phototransduction_Homo sapiens_hsa047440.17573866
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17182464
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.16997298
94Fat digestion and absorption_Homo sapiens_hsa049750.15929774
95Oocyte meiosis_Homo sapiens_hsa041140.15910453
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14883310
97Sulfur metabolism_Homo sapiens_hsa009200.13774193
98Amoebiasis_Homo sapiens_hsa051460.13320492
99Circadian rhythm_Homo sapiens_hsa047100.12305701
100Pancreatic secretion_Homo sapiens_hsa049720.11333149
101Renal cell carcinoma_Homo sapiens_hsa052110.10616224
102Tyrosine metabolism_Homo sapiens_hsa003500.10487341
103Ovarian steroidogenesis_Homo sapiens_hsa049130.09727560
104Platelet activation_Homo sapiens_hsa046110.09286258
105Olfactory transduction_Homo sapiens_hsa047400.08659184
106Cholinergic synapse_Homo sapiens_hsa047250.08489283
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08237279
108Proteoglycans in cancer_Homo sapiens_hsa052050.08225656
109Gap junction_Homo sapiens_hsa045400.07592103
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.07234767
111Taste transduction_Homo sapiens_hsa047420.05462325
112Dorso-ventral axis formation_Homo sapiens_hsa043200.04917445
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03569209
114mTOR signaling pathway_Homo sapiens_hsa041500.02724737
115Bile secretion_Homo sapiens_hsa049760.00488502
116GnRH signaling pathway_Homo sapiens_hsa049120.00206238
117Toxoplasmosis_Homo sapiens_hsa05145-1.1193865
118Glycerolipid metabolism_Homo sapiens_hsa00561-0.0333282
119FoxO signaling pathway_Homo sapiens_hsa04068-0.0324942
120PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0321313
121alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0290128
122VEGF signaling pathway_Homo sapiens_hsa04370-0.0090798
123Small cell lung cancer_Homo sapiens_hsa05222-0.0030579
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0026689

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