TNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.62461161
2* spermatid development (GO:0007286)9.54375085
3axonemal dynein complex assembly (GO:0070286)9.44473291
4motile cilium assembly (GO:0044458)9.43142231
5* reproduction (GO:0000003)8.70601919
6cilium movement (GO:0003341)8.16216892
7regulation of cilium movement (GO:0003352)7.93407973
8negative regulation of inclusion body assembly (GO:0090084)7.61659924
9sperm capacitation (GO:0048240)7.51779418
10cilium or flagellum-dependent cell motility (GO:0001539)7.46587767
11rRNA methylation (GO:0031167)7.44723625
12single fertilization (GO:0007338)7.42531659
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.23509555
14synaptonemal complex assembly (GO:0007130)7.11693144
15synaptonemal complex organization (GO:0070193)7.09746766
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.98205988
17spermatogenesis (GO:0007283)6.94371573
18male gamete generation (GO:0048232)6.91756263
19organic cation transport (GO:0015695)6.88424231
20protein targeting to Golgi (GO:0000042)6.66303039
21male meiosis (GO:0007140)6.60226678
22microtubule depolymerization (GO:0007019)6.55338517
23phosphatidylethanolamine metabolic process (GO:0046337)6.44426835
24regulation of inclusion body assembly (GO:0090083)6.40313413
25establishment of protein localization to Golgi (GO:0072600)6.38425338
26gamete generation (GO:0007276)6.35783018
27rRNA modification (GO:0000154)6.27600010
28fertilization (GO:0009566)6.24140541
29retrograde transport, vesicle recycling within Golgi (GO:0000301)6.20580912
30cellular ketone body metabolic process (GO:0046950)6.14790569
31calcium ion-dependent exocytosis (GO:0017156)6.06252208
32chromosome condensation (GO:0030261)5.96432005
33glycerol ether metabolic process (GO:0006662)5.73798991
34piRNA metabolic process (GO:0034587)5.69808527
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61173006
36DNA packaging (GO:0006323)5.55943431
37ketone body metabolic process (GO:1902224)5.42846474
38ether metabolic process (GO:0018904)5.30475008
39centriole replication (GO:0007099)5.29427648
40regulation of Rab GTPase activity (GO:0032313)5.28922222
41positive regulation of Rab GTPase activity (GO:0032851)5.28922222
42* cellular process involved in reproduction in multicellular organism (GO:0022412)5.23255767
43* germ cell development (GO:0007281)5.22153383
44cell recognition (GO:0008037)5.21824015
45multicellular organismal reproductive process (GO:0048609)4.99497478
46ventricular system development (GO:0021591)4.88101046
47protein localization to Golgi apparatus (GO:0034067)4.76500955
48microtubule severing (GO:0051013)4.74684271
49chromosome organization involved in meiosis (GO:0070192)4.72484101
50regulation of microtubule-based movement (GO:0060632)4.66363916
51regulation of transcription involved in cell fate commitment (GO:0060850)4.62428934
52protein K11-linked deubiquitination (GO:0035871)4.51575285
53seminiferous tubule development (GO:0072520)4.37895093
54regulation of centriole replication (GO:0046599)4.32955332
55sequestering of actin monomers (GO:0042989)4.28025852
56chaperone-mediated protein complex assembly (GO:0051131)4.11213551
57male meiosis I (GO:0007141)4.08455087
58coenzyme catabolic process (GO:0009109)4.04772729
59meiotic nuclear division (GO:0007126)3.96949826
60* multicellular organismal development (GO:0007275)3.90919195
61left/right pattern formation (GO:0060972)3.90177177
62negative regulation of Rho protein signal transduction (GO:0035024)3.85042565
63DNA methylation involved in gamete generation (GO:0043046)3.76477550
64multicellular organismal movement (GO:0050879)3.66888023
65musculoskeletal movement (GO:0050881)3.66888023
66response to acidic pH (GO:0010447)3.63166878
67genitalia morphogenesis (GO:0035112)3.60539028
68peptidyl-threonine dephosphorylation (GO:0035970)3.59376869
69cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.57031455
70regulation of interleukin-13 production (GO:0032656)3.51721028
71positive regulation of macrophage activation (GO:0043032)3.49201664
72glycolytic process (GO:0006096)3.49136591
73protein refolding (GO:0042026)3.48762658
74cerebral cortex neuron differentiation (GO:0021895)3.46688034
75regulation of T-helper 2 cell differentiation (GO:0045628)3.43070601
76microtubule polymerization or depolymerization (GO:0031109)3.42180918
77homeostasis of number of cells within a tissue (GO:0048873)3.40802687
78monoubiquitinated protein deubiquitination (GO:0035520)3.39674536
79cellular response to pH (GO:0071467)3.36757121
80histone H3-K9 demethylation (GO:0033169)3.35890411
81DNA conformation change (GO:0071103)3.30928296
82polyamine biosynthetic process (GO:0006596)3.30369254
83cranial nerve morphogenesis (GO:0021602)3.23190177
84glomerular visceral epithelial cell development (GO:0072015)3.23147741
85meiosis I (GO:0007127)3.21371707
86glomerular epithelial cell development (GO:0072310)3.15972665
87protein polyglutamylation (GO:0018095)3.15577077
88mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12417107
89mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12417107
90regulation of spindle checkpoint (GO:0090231)3.05284747
91interferon-gamma secretion (GO:0072643)3.03914171
92microtubule nucleation (GO:0007020)3.02704828
93cell differentiation involved in metanephros development (GO:0072202)3.01581232
94negative regulation of histone methylation (GO:0031061)3.00323364
95amino-acid betaine transport (GO:0015838)2.99365107
96carnitine transport (GO:0015879)2.99365107
97nucleoside diphosphate phosphorylation (GO:0006165)2.98252016
98receptor recycling (GO:0001881)2.92173502
99polyol catabolic process (GO:0046174)2.91960536
100meiotic cell cycle (GO:0051321)2.91445436
101alditol metabolic process (GO:0019400)2.89739745
102regulation of phosphoprotein phosphatase activity (GO:0043666)2.88367029
103positive regulation of skeletal muscle tissue development (GO:0048643)2.87326652
104regulation of somitogenesis (GO:0014807)2.86777925
105mitotic sister chromatid cohesion (GO:0007064)2.85169754
106mitochondrial fission (GO:0000266)2.85130965
107positive regulation of endothelial cell differentiation (GO:0045603)2.83164142
108NAD biosynthetic process (GO:0009435)2.82850852
109regulation of ARF GTPase activity (GO:0032312)2.82082131
110peptidyl-proline hydroxylation (GO:0019511)2.80789664
111negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.80483250
112carnitine transmembrane transport (GO:1902603)2.79482922
113mitotic G1 DNA damage checkpoint (GO:0031571)2.79481112
114GTP biosynthetic process (GO:0006183)2.78336151
115tooth mineralization (GO:0034505)2.75473327
116cilium organization (GO:0044782)2.71455923
117RNA localization (GO:0006403)2.68573588
118cilium assembly (GO:0042384)2.61161857
119cellular component assembly involved in morphogenesis (GO:0010927)2.60309738
120centriole assembly (GO:0098534)2.60128618
121regulation of cilium assembly (GO:1902017)2.59756049
122cellular response to arsenic-containing substance (GO:0071243)2.58841543
123RNA destabilization (GO:0050779)2.58833569
124meiotic cell cycle process (GO:1903046)2.58509282
125microtubule-based movement (GO:0007018)2.55217826
126lactate metabolic process (GO:0006089)2.49096230
127UTP biosynthetic process (GO:0006228)2.48816869
128synapsis (GO:0007129)2.47052049
129positive regulation of glycolytic process (GO:0045821)2.45955618
130glycerol metabolic process (GO:0006071)2.45407818
131cell redox homeostasis (GO:0045454)2.44666940
132macroautophagy (GO:0016236)2.44222785
133* nucleus organization (GO:0006997)2.43219249
134membrane protein intracellular domain proteolysis (GO:0031293)2.41783575
135protein localization to cilium (GO:0061512)2.41241380
136mitochondrion degradation (GO:0000422)2.39244253
137cilium morphogenesis (GO:0060271)2.34345474
138UTP metabolic process (GO:0046051)2.27687585
139protein depolymerization (GO:0051261)2.24109974
140cell wall macromolecule metabolic process (GO:0044036)16.1915279
141cell wall macromolecule catabolic process (GO:0016998)16.1915279
142* sperm motility (GO:0030317)14.2447999
143fusion of sperm to egg plasma membrane (GO:0007342)13.2448136
144acrosome reaction (GO:0007340)12.7364758
145sperm-egg recognition (GO:0035036)11.9400050
146acrosome assembly (GO:0001675)11.8765338
147binding of sperm to zona pellucida (GO:0007339)11.0040726
148multicellular organism reproduction (GO:0032504)10.8913025
149cell-cell recognition (GO:0009988)10.7187390
150epithelial cilium movement (GO:0003351)10.4440491
151plasma membrane fusion (GO:0045026)10.1138894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.82295361
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.92873614
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88743683
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.73589134
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.68892542
6EZH2_22144423_ChIP-Seq_EOC_Human3.61203059
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.51141430
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82216514
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79771382
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73526956
11VDR_22108803_ChIP-Seq_LS180_Human2.49111804
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36159238
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.25679850
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.23564259
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18934829
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.16442831
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09880142
18ERA_21632823_ChIP-Seq_H3396_Human2.05585699
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.00714609
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99083435
21RAC3_21632823_ChIP-Seq_H3396_Human1.92721817
22DROSHA_22980978_ChIP-Seq_HELA_Human1.90721367
23RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90448007
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89660619
25ZNF274_21170338_ChIP-Seq_K562_Hela1.89264636
26NANOG_20526341_ChIP-Seq_ESCs_Human1.87818357
27CTCF_27219007_Chip-Seq_Bcells_Human1.87268441
28* FLI1_27457419_Chip-Seq_LIVER_Mouse1.83688992
29BCL6_27268052_Chip-Seq_Bcells_Human1.79610763
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.78690831
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78226031
32STAT1_17558387_ChIP-Seq_HELA_Human1.76413051
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75254106
34FUS_26573619_Chip-Seq_HEK293_Human1.73603859
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.73433068
36KDM2B_26808549_Chip-Seq_REH_Human1.69936299
37SMC4_20622854_ChIP-Seq_HELA_Human1.69729769
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.69448740
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.69170839
40BCOR_27268052_Chip-Seq_Bcells_Human1.69141927
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68439668
42E2F1_20622854_ChIP-Seq_HELA_Human1.68407562
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68179786
44P68_20966046_ChIP-Seq_HELA_Human1.65594878
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.63948296
46GATA3_21867929_ChIP-Seq_CD8_Mouse1.63861338
47TAF2_19829295_ChIP-Seq_ESCs_Human1.63277550
48PHF8_20622854_ChIP-Seq_HELA_Human1.62664235
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62034503
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61498867
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61097395
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.59614250
53CTCF_20526341_ChIP-Seq_ESCs_Human1.57451021
54TP63_22573176_ChIP-Seq_HFKS_Human1.56368679
55ER_23166858_ChIP-Seq_MCF-7_Human1.56082674
56* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54624896
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54417278
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53785821
59LXR_22292898_ChIP-Seq_THP-1_Human1.53602816
60MYC_19829295_ChIP-Seq_ESCs_Human1.53295018
61OCT4_20526341_ChIP-Seq_ESCs_Human1.51929645
62* YY1_22570637_ChIP-Seq_MALME-3M_Human1.49512091
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.48077681
64P300_27268052_Chip-Seq_Bcells_Human1.44810015
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43086413
66CBP_20019798_ChIP-Seq_JUKART_Human1.43086413
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42994818
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42547866
69REST_21632747_ChIP-Seq_MESCs_Mouse1.41307186
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40457884
71P53_21459846_ChIP-Seq_SAOS-2_Human1.38695151
72FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38467134
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38068619
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.37331476
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.36868669
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36319676
77RBPJ_21746931_ChIP-Seq_IB4_Human1.36149648
78* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35778059
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34755995
80* SMAD4_21741376_ChIP-Seq_EPCs_Human1.33369606
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32451102
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31853118
83* AR_25329375_ChIP-Seq_VCAP_Human1.30892423
84TP53_18474530_ChIP-ChIP_U2OS_Human1.30695426
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.30688482
86* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29391921
87* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29156464
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.28294182
89CEBPB_22108803_ChIP-Seq_LS180_Human1.28208649
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27014864
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26788661
92* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26327602
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25386507
94* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.25355944
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25287404
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24893222
97CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24381080
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24108281
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24108281
100RUNX_20019798_ChIP-Seq_JUKART_Human1.23595397
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23296068
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23083410
103GF1_26923725_Chip-Seq_HPCs_Mouse1.22587761
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21604514
105SA1_27219007_Chip-Seq_Bcells_Human1.20447472
106CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20262102
107KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17927809
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.17670478
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17503709
110* ETV1_20927104_ChIP-Seq_GIST48_Human1.17053588
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.16714328
112* GATA3_21878914_ChIP-Seq_MCF-7_Human1.16290221
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15339644
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15070704
115* NFE2_27457419_Chip-Seq_LIVER_Mouse1.14915156
116ESET_19884257_ChIP-Seq_ESCs_Mouse1.14560800
117TBL1_22424771_ChIP-Seq_293T_Human1.14280809
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13401892
119* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12678559
120TAF15_26573619_Chip-Seq_HEK293_Human1.12050575
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12005877
122GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11797488
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.11658281
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09677357
125PHF8_20622853_ChIP-Seq_HELA_Human1.09668061
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.09607501
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.09431116
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08339837
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08100297
130* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07809458
131* SMRT_27268052_Chip-Seq_Bcells_Human1.07414460
132ERG_20517297_ChIP-Seq_VCAP_Human1.06845386
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06490899
134* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06438857
135* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05717602
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05699331
137SA1_27219007_Chip-Seq_ERYTHROID_Human1.05415400
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05186778
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04727862
140* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04714090
141* P300_19829295_ChIP-Seq_ESCs_Human1.04027199
142CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03515879
143* P53_22387025_ChIP-Seq_ESCs_Mouse1.03002596
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02994350
145* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02918507
146RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02691117
147SOX9_26525672_Chip-Seq_HEART_Mouse1.02606129
148TET1_21451524_ChIP-Seq_MESCs_Mouse1.02329169
149* OCT4_18555785_Chip-Seq_ESCs_Mouse1.02221543
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01726317
151* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01402103
152RARA_24833708_ChIP-Seq_LIVER_Mouse1.00749937
153MYC_27129775_Chip-Seq_CORNEA_Mouse1.00677456
154BP1_19119308_ChIP-ChIP_Hs578T_Human1.00548578
155OCT4_19829295_ChIP-Seq_ESCs_Human1.00216328
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00065172
157NFYA_21822215_ChIP-Seq_K562_Human0.99543919
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98839907
159NANOG_19829295_ChIP-Seq_ESCs_Human0.98835130
160SOX2_19829295_ChIP-Seq_ESCs_Human0.98835130
161* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98713780
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.98389856
163ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97757999
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95988307
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.95364068
166* P300_18555785_Chip-Seq_ESCs_Mouse0.95177346
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95119329
168NFYB_21822215_ChIP-Seq_K562_Human0.94860900
169* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94374226
170GF1B_26923725_Chip-Seq_HPCs_Mouse0.91480360
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89430509
172* KLF4_18555785_Chip-Seq_ESCs_Mouse0.89053892
173SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88702392
174NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87461115
175OCT1_27270436_Chip-Seq_PROSTATE_Human0.87323858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.06628339
2* MP0001929_abnormal_gametogenesis5.49478050
3MP0008877_abnormal_DNA_methylation3.54373862
4* MP0002161_abnormal_fertility/fecundity3.29994847
5MP0002210_abnormal_sex_determination3.29256134
6MP0005670_abnormal_white_adipose3.07812072
7MP0001145_abnormal_male_reproductive2.80838643
8MP0000678_abnormal_parathyroid_gland2.66581165
9MP0000653_abnormal_sex_gland2.42324526
10MP0003718_maternal_effect2.13616145
11MP0005410_abnormal_fertilization16.9417717
12MP0005379_endocrine/exocrine_gland_phen1.89263076
13MP0002249_abnormal_larynx_morphology1.70091014
14MP0002653_abnormal_ependyma_morphology1.68571453
15MP0004233_abnormal_muscle_weight1.59074252
16MP0005423_abnormal_somatic_nervous1.58882652
17MP0009053_abnormal_anal_canal1.52130612
18MP0001485_abnormal_pinna_reflex1.38018797
19MP0002160_abnormal_reproductive_system1.36186389
20MP0001486_abnormal_startle_reflex1.34245089
21MP0003646_muscle_fatigue1.28189910
22MP0001765_abnormal_ion_homeostasis1.26330144
23MP0005310_abnormal_salivary_gland1.25658824
24MP0002735_abnormal_chemical_nociception1.22782953
25MP0004510_myositis1.21158014
26MP0002138_abnormal_hepatobiliary_system1.20927484
27MP0002822_catalepsy1.18742265
28MP0004859_abnormal_synaptic_plasticity1.15167936
29MP0002127_abnormal_cardiovascular_syste1.13961728
30MP0005248_abnormal_Harderian_gland1.13908095
31MP0005623_abnormal_meninges_morphology1.08388475
32MP0002282_abnormal_trachea_morphology1.04138755
33MP0001963_abnormal_hearing_physiology1.00863648
34MP0002234_abnormal_pharynx_morphology0.99354713
35MP0005395_other_phenotype0.98478131
36MP0005451_abnormal_body_composition0.98102508
37MP0001984_abnormal_olfaction0.94528155
38MP0000681_abnormal_thyroid_gland0.91272955
39MP0000026_abnormal_inner_ear0.89755170
40MP0008058_abnormal_DNA_repair0.86527254
41MP0005647_abnormal_sex_gland0.81669206
42MP0000955_abnormal_spinal_cord0.78497419
43MP0000049_abnormal_middle_ear0.77973735
44MP0005636_abnormal_mineral_homeostasis0.74675570
45MP0000516_abnormal_urinary_system0.72032930
46MP0005367_renal/urinary_system_phenotyp0.72032930
47MP0001879_abnormal_lymphatic_vessel0.69558773
48MP0002067_abnormal_sensory_capabilities0.68267638
49MP0004085_abnormal_heartbeat0.66387941
50MP0002733_abnormal_thermal_nociception0.65916013
51MP0009046_muscle_twitch0.65880035
52MP0005083_abnormal_biliary_tract0.65192465
53MP0002736_abnormal_nociception_after0.65085027
54MP0002557_abnormal_social/conspecific_i0.65009442
55MP0005389_reproductive_system_phenotype0.64194412
56MP0003115_abnormal_respiratory_system0.63647038
57MP0003329_amyloid_beta_deposits0.59321477
58MP0005666_abnormal_adipose_tissue0.58822199
59MP0004036_abnormal_muscle_relaxation0.58121021
60MP0001905_abnormal_dopamine_level0.56405507
61MP0006036_abnormal_mitochondrial_physio0.54323063
62MP0001764_abnormal_homeostasis0.53933179
63MP0001666_abnormal_nutrient_absorption0.53218083
64MP0001324_abnormal_eye_pigmentation0.52572497
65MP0003011_delayed_dark_adaptation0.52145072
66MP0002139_abnormal_hepatobiliary_system0.51933866
67MP0002269_muscular_atrophy0.51750165
68MP0000003_abnormal_adipose_tissue0.51189734
69MP0005535_abnormal_body_temperature0.50896464
70MP0003077_abnormal_cell_cycle0.50629918
71MP0004484_altered_response_of0.49591818
72MP0002572_abnormal_emotion/affect_behav0.48813106
73MP0005167_abnormal_blood-brain_barrier0.48164745
74MP0009697_abnormal_copulation0.45066090
75MP0008961_abnormal_basal_metabolism0.45000626
76MP0000358_abnormal_cell_content/0.44819921
77MP0003119_abnormal_digestive_system0.43979523
78MP0009745_abnormal_behavioral_response0.43704869
79MP0001970_abnormal_pain_threshold0.43073614
80MP0003699_abnormal_female_reproductive0.42188730
81MP0000613_abnormal_salivary_gland0.42029936
82MP0001293_anophthalmia0.41562044
83MP0008995_early_reproductive_senescence0.41347505
84MP0002272_abnormal_nervous_system0.41295098
85MP0005551_abnormal_eye_electrophysiolog0.41272564
86MP0005377_hearing/vestibular/ear_phenot0.41262481
87MP0003878_abnormal_ear_physiology0.41262481
88MP0001968_abnormal_touch/_nociception0.40897566
89MP0002734_abnormal_mechanical_nocicepti0.40439803
90MP0003137_abnormal_impulse_conducting0.40179739
91MP0009115_abnormal_fat_cell0.39633485
92MP0006292_abnormal_olfactory_placode0.39622984
93MP0000249_abnormal_blood_vessel0.39419905
94MP0000470_abnormal_stomach_morphology0.38597886
95MP0005084_abnormal_gallbladder_morpholo0.38444790
96MP0001440_abnormal_grooming_behavior0.38379014
97MP0002928_abnormal_bile_duct0.38134600
98MP0002102_abnormal_ear_morphology0.37815658
99MP0003091_abnormal_cell_migration0.37298091
100MP0003880_abnormal_central_pattern0.37109266
101MP0003633_abnormal_nervous_system0.36915137
102MP0001501_abnormal_sleep_pattern0.36506551
103MP0000534_abnormal_ureter_morphology0.36361989
104MP0005253_abnormal_eye_physiology0.36319981
105MP0004133_heterotaxia0.36243008
106MP0004019_abnormal_vitamin_homeostasis0.35778625
107MP0002971_abnormal_brown_adipose0.35722474
108MP0000604_amyloidosis0.35223502
109MP0003936_abnormal_reproductive_system0.35211552
110MP0004145_abnormal_muscle_electrophysio0.34527457
111MP0000467_abnormal_esophagus_morphology0.34523770
112MP0006035_abnormal_mitochondrial_morpho0.34461913
113MP0001270_distended_abdomen0.34435615
114MP0005408_hypopigmentation0.33745200
115MP0004811_abnormal_neuron_physiology0.32169302
116MP0000566_synostosis0.31743953
117MP0001849_ear_inflammation0.30032284
118MP0003950_abnormal_plasma_membrane0.28723540
119MP0003631_nervous_system_phenotype0.26969513
120MP0008875_abnormal_xenobiotic_pharmacok0.26585790
121MP0005319_abnormal_enzyme/_coenzyme0.26236229
122MP0001545_abnormal_hematopoietic_system0.26116635
123MP0005397_hematopoietic_system_phenotyp0.26116635
124MP0005391_vision/eye_phenotype0.25915237
125MP0008569_lethality_at_weaning0.25683864
126MP0010094_abnormal_chromosome_stability0.25600249
127MP0002169_no_abnormal_phenotype0.25539819
128MP0002873_normal_phenotype0.25324518
129MP0005365_abnormal_bile_salt0.25267615
130MP0002693_abnormal_pancreas_physiology0.24692433
131MP0002132_abnormal_respiratory_system0.24043130
132MP0001119_abnormal_female_reproductive0.23907950
133MP0003942_abnormal_urinary_system0.22730765
134MP0004270_analgesia0.22174985
135MP0000569_abnormal_digit_pigmentation0.21224965
136MP0003948_abnormal_gas_homeostasis0.20727148
137MP0002152_abnormal_brain_morphology0.20368290
138MP0009278_abnormal_bone_marrow0.20294587
139MP0004742_abnormal_vestibular_system0.20180761
140MP0003861_abnormal_nervous_system0.19433589
141MP0001348_abnormal_lacrimal_gland0.19345344
142MP0004043_abnormal_pH_regulation0.18849269
143MP0002118_abnormal_lipid_homeostasis0.18822177
144MP0004084_abnormal_cardiac_muscle0.18152583
145MP0002909_abnormal_adrenal_gland0.17399476
146MP0002229_neurodegeneration0.17100034
147MP0003879_abnormal_hair_cell0.16572444
148MP0001730_embryonic_growth_arrest0.15747808
149MP0005360_urolithiasis0.15646784
150MP0000920_abnormal_myelination0.15007922
151MP0003959_abnormal_lean_body0.14975412
152MP0000462_abnormal_digestive_system0.14752673
153MP0003111_abnormal_nucleus_morphology0.14712189
154MP0000001_mammalian_phenotype0.14212478
155MP0000751_myopathy0.14199477
156MP0002295_abnormal_pulmonary_circulatio0.14097660
157MP0005375_adipose_tissue_phenotype0.14080885
158MP0010329_abnormal_lipoprotein_level0.13491499
159MP0005195_abnormal_posterior_eye0.12035281
160MP0003279_aneurysm0.11852073
161MP0002092_abnormal_eye_morphology0.11598750

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.50749431
2Abnormal respiratory motile cilium morphology (HP:0005938)9.50749431
3Abnormal respiratory motile cilium physiology (HP:0012261)9.30179745
4Severe visual impairment (HP:0001141)8.62999171
5Chronic bronchitis (HP:0004469)7.54212143
6Abnormal ciliary motility (HP:0012262)7.43156999
7Rhinitis (HP:0012384)7.23827122
8Infertility (HP:0000789)6.84467755
9Nasal polyposis (HP:0100582)6.37357531
10Abnormality of the nasal mucosa (HP:0000433)5.25026323
11Bony spicule pigmentary retinopathy (HP:0007737)5.21892562
12Attenuation of retinal blood vessels (HP:0007843)5.20399946
13Male infertility (HP:0003251)4.86531122
14Resting tremor (HP:0002322)4.64956595
15Hyperkalemia (HP:0002153)4.59774434
16Bronchitis (HP:0012387)4.45431019
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.40146690
18Chronic hepatic failure (HP:0100626)4.39318966
19Bronchiectasis (HP:0002110)4.28376896
20Abnormal rod and cone electroretinograms (HP:0008323)4.13930901
21Abnormality of macular pigmentation (HP:0008002)4.09669027
22Potter facies (HP:0002009)4.09325730
23Facial shape deformation (HP:0011334)4.09325730
24Nephronophthisis (HP:0000090)3.89108621
25Cone-rod dystrophy (HP:0000548)3.66694493
26Hypoplastic ischia (HP:0003175)3.64872099
27Abnormal spermatogenesis (HP:0008669)3.53446286
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.49435565
29Recurrent sinusitis (HP:0011108)3.35995586
30Enlarged epiphyses (HP:0010580)3.35622808
31Abnormality of the ischium (HP:0003174)3.25257808
32Hypoplasia of the thymus (HP:0000778)3.21096007
33Recurrent otitis media (HP:0000403)3.19442802
34Unilateral renal agenesis (HP:0000122)3.17603993
35Progressive sensorineural hearing impairment (HP:0000408)3.04997381
36Postural instability (HP:0002172)3.01150713
37Hypoalphalipoproteinemia (HP:0003233)2.94544628
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92741577
39Abnormality of the renal medulla (HP:0100957)2.91969270
40Tubulointerstitial nephritis (HP:0001970)2.90174999
41Abnormality of the aortic arch (HP:0012303)2.82661997
42Abnormality of potassium homeostasis (HP:0011042)2.61886037
43Generalized aminoaciduria (HP:0002909)2.61372347
44Medial flaring of the eyebrow (HP:0010747)2.56946549
45Progressive cerebellar ataxia (HP:0002073)2.56406178
46Tubular atrophy (HP:0000092)2.56123461
47Molar tooth sign on MRI (HP:0002419)2.55281760
48Abnormality of midbrain morphology (HP:0002418)2.55281760
49Amelogenesis imperfecta (HP:0000705)2.50829295
50Cholecystitis (HP:0001082)2.47995319
51Abnormal gallbladder physiology (HP:0012438)2.47995319
52Recurrent bronchitis (HP:0002837)2.39576936
53Abnormality of dental color (HP:0011073)2.39056649
54Menstrual irregularities (HP:0000858)2.38874254
55Renovascular hypertension (HP:0100817)2.38714513
56Abnormality of the costochondral junction (HP:0000919)2.37048160
57Insulin-resistant diabetes mellitus (HP:0000831)2.35696591
58Tubulointerstitial abnormality (HP:0001969)2.32719455
59Abnormality of the parathyroid morphology (HP:0011766)2.32193584
60Portal hypertension (HP:0001409)2.30735079
61Azoospermia (HP:0000027)2.18323105
62Ventricular tachycardia (HP:0004756)2.18204419
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17494719
64Polyuria (HP:0000103)2.17091965
65Impulsivity (HP:0100710)2.16782985
66Flattened epiphyses (HP:0003071)2.16628458
67Asymmetric septal hypertrophy (HP:0001670)2.15409419
68Dyschromatopsia (HP:0007641)2.12228596
69Abnormality of the hepatic vasculature (HP:0006707)2.10118577
70Osteomalacia (HP:0002749)2.08848421
71Epiphyseal dysplasia (HP:0002656)2.05561963
72Hyponatremia (HP:0002902)2.05555987
73Widely patent fontanelles and sutures (HP:0004492)2.05215161
74Tetany (HP:0001281)2.01004247
75Double outlet right ventricle (HP:0001719)2.00447067
76Congenital malformation of the right heart (HP:0011723)2.00447067
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.7981231
78Absent/shortened dynein arms (HP:0200106)13.7981231
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7724787
80Myokymia (HP:0002411)1.96366291
81Progressive hearing impairment (HP:0001730)1.94523109
82Decreased central vision (HP:0007663)1.93920629
83Abnormal ventriculo-arterial connection (HP:0011563)1.93356913
84Transposition of the great arteries (HP:0001669)1.93356913
85Abnormal connection of the cardiac segments (HP:0011545)1.93356913
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.93085724
87Increased purine levels (HP:0004368)1.91978711
88Hyperuricemia (HP:0002149)1.91978711
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90233138
90Absent epiphyses (HP:0010577)1.90233138
91Spastic paraparesis (HP:0002313)1.88419874
92Abnormality of the pubic bones (HP:0003172)1.88132398
93Hyperthyroidism (HP:0000836)1.87568159
94Choroideremia (HP:0001139)1.86049506
95Hypoparathyroidism (HP:0000829)1.84021683
96Focal segmental glomerulosclerosis (HP:0000097)1.83954463
97Flat capital femoral epiphysis (HP:0003370)1.83535215
98Neoplasm of the heart (HP:0100544)1.81015332
99Abnormality of femoral epiphyses (HP:0006499)1.79842606
100Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.79842606
101Recurrent pneumonia (HP:0006532)1.79753983
102Hypophosphatemic rickets (HP:0004912)1.79306582
103Bundle branch block (HP:0011710)1.77909469
104Gonadotropin excess (HP:0000837)1.77809083
105Tubulointerstitial fibrosis (HP:0005576)1.75939222
106Stage 5 chronic kidney disease (HP:0003774)1.68826228
107Abnormality of renal excretion (HP:0011036)1.68032194
108Hemorrhage of the eye (HP:0011885)1.68020245
109Spastic tetraparesis (HP:0001285)1.67683659
110Constricted visual fields (HP:0001133)1.63867202
111Abnormal drinking behavior (HP:0030082)1.63148281
112Polydipsia (HP:0001959)1.63148281
113Abnormal biliary tract physiology (HP:0012439)1.62095381
114Bile duct proliferation (HP:0001408)1.62095381
115Postaxial foot polydactyly (HP:0001830)1.61345123
116Aplasia/Hypoplasia of the lens (HP:0008063)1.57620556
117Heterotopia (HP:0002282)1.56262448
118Abnormality of the renal cortex (HP:0011035)1.55011549
119Neurofibrillary tangles (HP:0002185)1.52619811
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52086041
121Congenital hepatic fibrosis (HP:0002612)1.51821969
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.51764892
123Optic nerve hypoplasia (HP:0000609)1.50225909
124Sensory axonal neuropathy (HP:0003390)1.49391132
125Abnormality of permanent molar morphology (HP:0011071)1.48695672
126Abnormality of the dental root (HP:0006486)1.48695672
127Taurodontia (HP:0000679)1.48695672
128Gait imbalance (HP:0002141)1.45907889
129Abnormality of the neuromuscular junction (HP:0003398)1.45741066
130Fatigable weakness (HP:0003473)1.45741066
131Chronic sinusitis (HP:0011109)1.45183540
132Congenital primary aphakia (HP:0007707)1.44914856
133Oculomotor apraxia (HP:0000657)1.43663048
134Exercise-induced myalgia (HP:0003738)1.43370626
135Bell-shaped thorax (HP:0001591)1.42143389
136Easy fatigability (HP:0003388)1.40503968
137Abnormality of the dental pulp (HP:0006479)1.39323853
138Abnormality of molar morphology (HP:0011070)1.36657331
139Abnormality of molar (HP:0011077)1.36657331
140Myoglobinuria (HP:0002913)1.36114483
141Abnormality of saccadic eye movements (HP:0000570)1.36010809
142Postaxial hand polydactyly (HP:0001162)1.35318423
143Abnormal urine output (HP:0012590)1.31705232
144Cystic liver disease (HP:0006706)1.31399395
145Short ribs (HP:0000773)1.29793830
146Vascular calcification (HP:0004934)1.29112641
147Hypercholesterolemia (HP:0003124)1.28799493
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.27132633
149Cerebral inclusion bodies (HP:0100314)1.26319378
150Type 2 muscle fiber atrophy (HP:0003554)1.24639028
151Impaired smooth pursuit (HP:0007772)1.23321167
152Rhabdomyolysis (HP:0003201)1.22972811
153Cerebellar dysplasia (HP:0007033)1.21381140
154Abnormality of ocular smooth pursuit (HP:0000617)1.21252949
155Nephrogenic diabetes insipidus (HP:0009806)1.21132049
156Pancreatic fibrosis (HP:0100732)1.21046245
157Loss of speech (HP:0002371)1.20077743
158Abnormality of dentin (HP:0010299)1.19650969
159Exercise-induced muscle cramps (HP:0003710)1.19488904
160Hypoplasia of the capital femoral epiphysis (HP:0003090)1.18043948
161Vaginal atresia (HP:0000148)1.17406069
162Cardiovascular calcification (HP:0011915)1.16033807
163Renal dysplasia (HP:0000110)1.14770616
164Truncal obesity (HP:0001956)1.14188172
165Genital tract atresia (HP:0001827)1.13573821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.26172714
2PDK39.26172714
3PDK26.02667311
4TESK15.35435835
5DDR24.66077938
6PRKD33.86906589
7ICK3.84603053
8MAP4K23.68747340
9INSRR3.16809394
10BRD43.02584905
11PLK23.00152216
12MST1R1.86852745
13PTK2B1.80860708
14WNK41.64721893
15STK391.61166159
16PIK3CG1.55610801
17STK381.54522720
18DYRK1B1.38498794
19CDK121.33639476
20CDK71.30523702
21PDK11.30407429
22MAP3K91.24633255
23NEK21.21081624
24PNCK1.18352818
25KSR21.12489618
26LATS21.03990874
27IRAK11.01447055
28AKT30.89095174
29SIK20.86163494
30CAMK1D0.85403105
31UHMK10.83411346
32LMTK20.80011091
33RIPK40.78444292
34MAP3K110.77425201
35PDPK10.76695658
36DYRK30.75644589
37RPS6KA20.69260014
38PRKAA20.66507760
39MAP2K20.65673822
40TYRO30.63785813
41MAP3K80.63125787
42MAP3K20.62620106
43IRAK20.60637487
44MAP2K60.60358988
45MAPK150.58543265
46EEF2K0.57569340
47WNK10.54989056
48ROCK10.54461612
49CAMK10.53090768
50PASK0.52740084
51CCNB10.52666368
52CDK30.47641495
53CHEK20.47572132
54MUSK0.47522670
55LATS10.47171867
56SGK4940.45537900
57SGK2230.45537900
58PINK10.44604894
59BMPR1B0.44476812
60CDK40.42363923
61TTK0.41452841
62MAPK10.40941762
63MAP3K10.40406535
64STK30.39972444
65RPS6KL10.36915210
66RPS6KC10.36915210
67NTRK20.36767939
68ARAF0.35870982
69STK38L0.35105555
70PRKCG0.34726887
71RPS6KA60.34155359
72MAP3K100.33841423
73CAMK40.33248189
74PAK10.32199383
75TESK20.32093573
76SGK10.31914844
77CAMK1G0.28398828
78CHEK10.28383863
79PLK40.27047613
80MET0.26312347
81TIE10.25072538
82MAPK140.24825021
83NTRK30.24325053
84PAK20.22606364
85PRKCZ0.22386884
86MAPKAPK50.22145931
87CAMKK10.19917546
88MARK20.19617495
89MAPK110.19154112
90PRKG20.18375725
91AKT10.17913487
92ATM0.16964237
93FER0.16557309
94MAP3K40.16547797
95OXSR10.16129072
96CDK150.15897883
97MTOR0.14669843
98PRKCQ0.14656048
99BRSK20.13452123
100CDK180.13412007
101PAK40.12689304
102BLK0.12612385
103PRKAA10.12575238
104CDK11A0.11777959
105MINK10.10207850
106CDK140.09641343
107IKBKB0.09371195
108RPS6KB10.09050841
109NEK60.09034729
110PKN10.08764550
111TNIK0.08595201
112ATR0.07842392
113MARK30.07481497
114YES10.06875715
115BRSK10.06427329
116MAPK90.06198056
117SGK20.05897685
118CHUK0.05344739
119CSNK2A10.05286983
120RPS6KA10.05184628
121PLK10.05017065
122PRKCD0.04900486
123PRKACG0.04826260
124GSK3B0.04787252
125CAMK2A0.04671296
126JAK30.04492378
127PRKG10.04261985
128BRAF0.03487878
129MAP3K50.03338965
130WEE10.03106862
131CDK60.02832074
132CSF1R0.02426145
133PIM10.02336705
134STK100.02319540
135PRKCB0.02292253
136PRKCA0.01698124
137GSK3A0.01502516
138CSNK2A20.01495538
139MAPK80.01196293
140CDC70.00471462
141TRIB30.00324699
142PAK6-0.0403983
143MAPK10-0.0403948
144PDGFRB-0.0336347
145MARK1-0.0310391
146PRKACA-0.0254305
147CSNK1D-0.0225575
148CLK1-0.0213438
149WNK3-0.0169475
150EGFR-0.0164394
151PRKACB-0.0117387
152CDK1-0.0114914
153RPS6KA3-0.0069540
154STK11-0.0027590
155CDK2-0.0016165

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.37195531
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.65216258
3Fatty acid biosynthesis_Homo sapiens_hsa000614.45353621
4Olfactory transduction_Homo sapiens_hsa047403.50425844
5Pyruvate metabolism_Homo sapiens_hsa006203.38326861
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.27929597
7Vitamin B6 metabolism_Homo sapiens_hsa007503.11578095
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06397339
9Linoleic acid metabolism_Homo sapiens_hsa005912.98969176
10Butanoate metabolism_Homo sapiens_hsa006502.73860277
11Glucagon signaling pathway_Homo sapiens_hsa049222.49485577
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.47305289
13Propanoate metabolism_Homo sapiens_hsa006402.42469528
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04416330
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03458369
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.98654570
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97506720
18Type I diabetes mellitus_Homo sapiens_hsa049401.92861603
19Allograft rejection_Homo sapiens_hsa053301.91215129
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88545296
21Glycerolipid metabolism_Homo sapiens_hsa005611.87254414
22Basal transcription factors_Homo sapiens_hsa030221.87253658
23Autoimmune thyroid disease_Homo sapiens_hsa053201.85174147
24Selenocompound metabolism_Homo sapiens_hsa004501.80493149
25PPAR signaling pathway_Homo sapiens_hsa033201.76146969
26Graft-versus-host disease_Homo sapiens_hsa053321.75268492
27Mineral absorption_Homo sapiens_hsa049781.71924013
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.70227516
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69257214
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66930359
31Oocyte meiosis_Homo sapiens_hsa041141.65019035
32Type II diabetes mellitus_Homo sapiens_hsa049301.55905139
33Fat digestion and absorption_Homo sapiens_hsa049751.54923319
34Carbon metabolism_Homo sapiens_hsa012001.47929755
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46514740
36Fructose and mannose metabolism_Homo sapiens_hsa000511.45553579
37Ether lipid metabolism_Homo sapiens_hsa005651.43708014
38Phenylalanine metabolism_Homo sapiens_hsa003601.42437766
39Cardiac muscle contraction_Homo sapiens_hsa042601.41266587
40Fatty acid degradation_Homo sapiens_hsa000711.39530846
41Amphetamine addiction_Homo sapiens_hsa050311.37014671
42Viral myocarditis_Homo sapiens_hsa054161.35188502
43Fatty acid metabolism_Homo sapiens_hsa012121.34110790
44Pentose phosphate pathway_Homo sapiens_hsa000301.29499000
45Arginine and proline metabolism_Homo sapiens_hsa003301.23866876
46Glutathione metabolism_Homo sapiens_hsa004801.18672037
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16932706
48Collecting duct acid secretion_Homo sapiens_hsa049661.16058026
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08317765
50Antigen processing and presentation_Homo sapiens_hsa046121.06494995
51Bile secretion_Homo sapiens_hsa049761.01907719
52Dorso-ventral axis formation_Homo sapiens_hsa043201.01533397
53Renin secretion_Homo sapiens_hsa049240.99802726
54Phototransduction_Homo sapiens_hsa047440.98315697
55Purine metabolism_Homo sapiens_hsa002300.96969601
56Insulin secretion_Homo sapiens_hsa049110.95189325
57Chemical carcinogenesis_Homo sapiens_hsa052040.93308928
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.92336050
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91333122
60Biosynthesis of amino acids_Homo sapiens_hsa012300.88645351
61Thyroid hormone synthesis_Homo sapiens_hsa049180.88037905
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86884989
63Hedgehog signaling pathway_Homo sapiens_hsa043400.86121450
64Arginine biosynthesis_Homo sapiens_hsa002200.85030074
65Influenza A_Homo sapiens_hsa051640.79216615
66Morphine addiction_Homo sapiens_hsa050320.79203095
67Arachidonic acid metabolism_Homo sapiens_hsa005900.76494927
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.75733562
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74494714
70Huntingtons disease_Homo sapiens_hsa050160.74260096
71Systemic lupus erythematosus_Homo sapiens_hsa053220.72729558
72Estrogen signaling pathway_Homo sapiens_hsa049150.72369722
73Salivary secretion_Homo sapiens_hsa049700.70332801
74Sulfur metabolism_Homo sapiens_hsa009200.69999488
75Pancreatic secretion_Homo sapiens_hsa049720.69714619
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.69471548
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66835331
78Fanconi anemia pathway_Homo sapiens_hsa034600.66686194
79Long-term potentiation_Homo sapiens_hsa047200.66106064
80mRNA surveillance pathway_Homo sapiens_hsa030150.65930236
81Inositol phosphate metabolism_Homo sapiens_hsa005620.65726963
82Synaptic vesicle cycle_Homo sapiens_hsa047210.63696799
83Legionellosis_Homo sapiens_hsa051340.62800909
84Gastric acid secretion_Homo sapiens_hsa049710.62450102
85Tyrosine metabolism_Homo sapiens_hsa003500.61277398
86Protein digestion and absorption_Homo sapiens_hsa049740.60829747
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58817279
88Nicotine addiction_Homo sapiens_hsa050330.56422647
89Calcium signaling pathway_Homo sapiens_hsa040200.55400529
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54209413
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54098523
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53543334
93Renin-angiotensin system_Homo sapiens_hsa046140.51046063
94Retinol metabolism_Homo sapiens_hsa008300.50993893
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.49376141
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.48200414
97Acute myeloid leukemia_Homo sapiens_hsa052210.48178975
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47384433
99Tight junction_Homo sapiens_hsa045300.46300312
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46241530
101MAPK signaling pathway_Homo sapiens_hsa040100.45988174
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.44109329
103ABC transporters_Homo sapiens_hsa020100.43959999
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42847940
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41922198
106Endocytosis_Homo sapiens_hsa041440.41665710
107Metabolic pathways_Homo sapiens_hsa011000.41107309
108RNA transport_Homo sapiens_hsa030130.40098935
109Circadian entrainment_Homo sapiens_hsa047130.39001781
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37960963
111AMPK signaling pathway_Homo sapiens_hsa041520.37105679
112cAMP signaling pathway_Homo sapiens_hsa040240.36637342
113Alcoholism_Homo sapiens_hsa050340.34243561
114Viral carcinogenesis_Homo sapiens_hsa052030.30256487
115Taste transduction_Homo sapiens_hsa047420.29943568
116Cholinergic synapse_Homo sapiens_hsa047250.29493581
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27919125
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27368399
119Serotonergic synapse_Homo sapiens_hsa047260.26781374
120VEGF signaling pathway_Homo sapiens_hsa043700.25761219
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.25230471
122Oxytocin signaling pathway_Homo sapiens_hsa049210.23086529
123GABAergic synapse_Homo sapiens_hsa047270.21474668
124Nitrogen metabolism_Homo sapiens_hsa009100.20456547
125Herpes simplex infection_Homo sapiens_hsa051680.20185548
126Pyrimidine metabolism_Homo sapiens_hsa002400.19625875
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18398039
128Prolactin signaling pathway_Homo sapiens_hsa049170.18242735
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17164828
130HIF-1 signaling pathway_Homo sapiens_hsa040660.16223932
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15808653
132Cocaine addiction_Homo sapiens_hsa050300.15264699
133ECM-receptor interaction_Homo sapiens_hsa045120.13735065
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13412793
135Toxoplasmosis_Homo sapiens_hsa051450.12911032
136Adherens junction_Homo sapiens_hsa045200.12767826
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12698333
138Salmonella infection_Homo sapiens_hsa051320.11042001
139Wnt signaling pathway_Homo sapiens_hsa043100.06329358
140Glutamatergic synapse_Homo sapiens_hsa047240.05577696
141B cell receptor signaling pathway_Homo sapiens_hsa046620.03992309
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.02341592
143Vibrio cholerae infection_Homo sapiens_hsa051100.01771275
144Insulin resistance_Homo sapiens_hsa049310.01140321

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