TNPO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.91030076
2nuclear pore organization (GO:0006999)5.72762780
3mitotic sister chromatid cohesion (GO:0007064)4.85302507
4pre-miRNA processing (GO:0031054)4.71841368
5pore complex assembly (GO:0046931)4.43963093
6DNA unwinding involved in DNA replication (GO:0006268)4.24828174
7protein localization to kinetochore (GO:0034501)4.21145431
8negative regulation of histone methylation (GO:0031061)4.14547277
9regulation of RNA export from nucleus (GO:0046831)4.02243217
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98144680
11mitotic chromosome condensation (GO:0007076)3.88083777
12mitotic nuclear envelope disassembly (GO:0007077)3.86109231
13regulation of sister chromatid cohesion (GO:0007063)3.78909003
14cytoplasmic mRNA processing body assembly (GO:0033962)3.77963339
15folic acid-containing compound biosynthetic process (GO:0009396)3.72369602
16membrane disassembly (GO:0030397)3.69319485
17nuclear envelope disassembly (GO:0051081)3.69319485
18heterochromatin organization (GO:0070828)3.67899691
19sister chromatid segregation (GO:0000819)3.66440682
20regulation of histone H3-K9 methylation (GO:0051570)3.65041463
21dosage compensation (GO:0007549)3.61889668
22histone H2A monoubiquitination (GO:0035518)3.60424030
23DNA replication-dependent nucleosome organization (GO:0034723)3.47209368
24DNA replication-dependent nucleosome assembly (GO:0006335)3.47209368
25peptidyl-lysine dimethylation (GO:0018027)3.47192543
26chromatin assembly (GO:0031497)3.46314497
27DNA duplex unwinding (GO:0032508)3.45770777
28DNA geometric change (GO:0032392)3.43689346
29protein localization to chromosome, centromeric region (GO:0071459)3.42743197
30RNA stabilization (GO:0043489)3.42176333
31mRNA stabilization (GO:0048255)3.42176333
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.39794493
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.39794493
34positive regulation of mitotic sister chromatid separation (GO:1901970)3.39794493
35mitotic cytokinesis (GO:0000281)3.35835526
36paraxial mesoderm development (GO:0048339)3.35373588
37regulation of translational fidelity (GO:0006450)3.34526259
38glucocorticoid receptor signaling pathway (GO:0042921)3.27459300
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24566129
40translesion synthesis (GO:0019985)3.22460751
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.19062374
42regulation of nucleobase-containing compound transport (GO:0032239)3.19020096
43negative regulation of DNA repair (GO:0045738)3.16454860
44positive regulation of chromosome segregation (GO:0051984)3.13190711
45NLS-bearing protein import into nucleus (GO:0006607)3.12912522
46notochord development (GO:0030903)3.12142048
47regulation of spindle organization (GO:0090224)3.11924727
48cytoskeleton-dependent cytokinesis (GO:0061640)3.10363207
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08375399
50cellular protein complex localization (GO:0034629)3.08278274
51histone H3-K9 demethylation (GO:0033169)3.08134324
52cell adhesion mediated by integrin (GO:0033627)3.05374635
53regulation of gene silencing by RNA (GO:0060966)3.05185925
54regulation of posttranscriptional gene silencing (GO:0060147)3.05185925
55regulation of gene silencing by miRNA (GO:0060964)3.05185925
56gene silencing by RNA (GO:0031047)3.04258423
57regulation of mitotic spindle organization (GO:0060236)3.03876192
58alternative mRNA splicing, via spliceosome (GO:0000380)3.01805988
59embryonic foregut morphogenesis (GO:0048617)3.01387420
60positive regulation of SMAD protein import into nucleus (GO:0060391)3.01299638
61monoubiquitinated protein deubiquitination (GO:0035520)3.00925355
62retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00770128
63COPI coating of Golgi vesicle (GO:0048205)2.97003903
64Golgi transport vesicle coating (GO:0048200)2.97003903
65double-strand break repair via nonhomologous end joining (GO:0006303)2.97000225
66non-recombinational repair (GO:0000726)2.97000225
67mitotic sister chromatid segregation (GO:0000070)2.96575064
68nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.95689991
69stress granule assembly (GO:0034063)2.95596659
70protein localization to chromosome (GO:0034502)2.93010473
71nuclear envelope organization (GO:0006998)2.91462713
72protein complex localization (GO:0031503)2.90881119
73hippo signaling (GO:0035329)2.88273132
74DNA topological change (GO:0006265)2.85875865
75chromatin assembly or disassembly (GO:0006333)2.84560861
76negative regulation of RNA splicing (GO:0033119)2.83297697
77IMP biosynthetic process (GO:0006188)2.82958711
78mitotic metaphase plate congression (GO:0007080)2.81603636
79regulation of NFAT protein import into nucleus (GO:0051532)2.79952793
80establishment of integrated proviral latency (GO:0075713)2.79476334
81gap junction assembly (GO:0016264)2.78658922
82negative regulation of histone modification (GO:0031057)2.77747685
83morphogenesis of an epithelial sheet (GO:0002011)2.77532882
84protein export from nucleus (GO:0006611)2.77264319
85dorsal/ventral axis specification (GO:0009950)2.76911587
86regulation of centriole replication (GO:0046599)2.76138032
87histone-serine phosphorylation (GO:0035404)2.76128225
88regulation of chromosome segregation (GO:0051983)2.75855478
89regulation of mRNA stability (GO:0043488)2.75597845
90corticosteroid receptor signaling pathway (GO:0031958)2.75043912
91negative regulation of mRNA metabolic process (GO:1903312)2.73445491
92DNA conformation change (GO:0071103)2.72469848
93negative regulation of mRNA processing (GO:0050686)2.71319941
94regulation of DNA endoreduplication (GO:0032875)2.71141268
95regulation of translational termination (GO:0006449)2.71085717
96spindle assembly checkpoint (GO:0071173)2.70045009
97spindle checkpoint (GO:0031577)2.69270754
98gene silencing (GO:0016458)2.68653269
99mRNA transport (GO:0051028)2.65970584
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65223900
101metaphase plate congression (GO:0051310)2.64327923
102negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.63950109
103histone H3-K9 methylation (GO:0051567)2.63627807
104histone lysine demethylation (GO:0070076)2.63567280
105chromosome condensation (GO:0030261)2.62867866
106regulation of centrosome duplication (GO:0010824)2.62435129
107negative regulation of chromatin modification (GO:1903309)2.62133561
108establishment of chromosome localization (GO:0051303)2.62046820
109regulation of telomere maintenance via telomerase (GO:0032210)2.61722576
110regulation of centrosome cycle (GO:0046605)2.60663610
111cell migration involved in sprouting angiogenesis (GO:0002042)2.60443694
112DNA strand elongation involved in DNA replication (GO:0006271)2.59330521
113regulation of SMAD protein import into nucleus (GO:0060390)2.59192030
114DNA replication initiation (GO:0006270)2.58203067
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58161783
116mitotic spindle checkpoint (GO:0071174)2.58040676
117midgut development (GO:0007494)2.57678111
118protein localization to microtubule (GO:0035372)2.57605231
119regulation of transforming growth factor beta2 production (GO:0032909)2.56976487
120mitotic spindle assembly checkpoint (GO:0007094)2.56761403
121attachment of spindle microtubules to kinetochore (GO:0008608)2.56677055
122kinetochore organization (GO:0051383)2.56076919
123histone demethylation (GO:0016577)2.55340635
124regulation of RNA stability (GO:0043487)2.55333728
125DNA strand elongation (GO:0022616)2.54145775
126mitotic spindle organization (GO:0007052)2.51603187
127negative regulation of chondrocyte differentiation (GO:0032331)2.45323028
128SMAD protein complex assembly (GO:0007183)2.45081422
129positive regulation of cell cycle checkpoint (GO:1901978)2.40131986
130negative regulation of fibroblast apoptotic process (GO:2000270)2.39236612
131establishment of apical/basal cell polarity (GO:0035089)2.38015556
132hemidesmosome assembly (GO:0031581)2.36876510
133DNA synthesis involved in DNA repair (GO:0000731)2.32547587
134ATP-dependent chromatin remodeling (GO:0043044)2.31894295
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.31044658
136chondrocyte proliferation (GO:0035988)2.30684941
137COPII vesicle coating (GO:0048208)2.30376905
138regulation of DNA damage checkpoint (GO:2000001)2.29734660
139negative regulation of chromosome segregation (GO:0051985)2.25973387
140regulation of sister chromatid segregation (GO:0033045)2.25525337
141regulation of mitotic sister chromatid separation (GO:0010965)2.25525337
142regulation of mitotic sister chromatid segregation (GO:0033047)2.25525337
143adherens junction assembly (GO:0034333)2.24467792
144microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.23845529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.55581761
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.92994882
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.18773446
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.14360105
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79121297
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.76062169
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40711901
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15976436
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96293540
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.63432222
11MYC_22102868_ChIP-Seq_BL_Human2.58529625
12AR_21909140_ChIP-Seq_LNCAP_Human2.57181542
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51811266
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.51142058
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.42156958
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21250511
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.90849471
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88984885
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86097158
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84114330
21CLOCK_20551151_ChIP-Seq_293T_Human1.79805097
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78978365
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74360505
24* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71778822
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70102067
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69105637
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67892951
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63904803
29GATA1_22025678_ChIP-Seq_K562_Human1.60878325
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56800800
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56797939
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54606054
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54226985
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53875032
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52725982
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51491543
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51233029
38* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50380102
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47610842
40* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46821740
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43733621
42CHD1_26751641_Chip-Seq_LNCaP_Human1.42162780
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41849405
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41728140
45KDM5A_27292631_Chip-Seq_BREAST_Human1.40498393
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40400604
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38472077
48* NANOG_21062744_ChIP-ChIP_HESCs_Human1.38016009
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36534944
50SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36333904
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33641094
52CIITA_25753668_ChIP-Seq_RAJI_Human1.33386913
53FUS_26573619_Chip-Seq_HEK293_Human1.29690549
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29247661
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28952096
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27154494
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26986471
58XRN2_22483619_ChIP-Seq_HELA_Human1.26077971
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.25535238
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24613710
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24034030
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23956821
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23039405
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22564510
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22317112
66* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21762263
67TCF7_22412390_ChIP-Seq_EML_Mouse1.21759665
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20385841
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20227409
70* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20227409
71TFEB_21752829_ChIP-Seq_HELA_Human1.18867194
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17787777
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15691582
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15487046
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15356521
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14800411
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14784355
78ELK1_19687146_ChIP-ChIP_HELA_Human1.13152799
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12041076
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11014520
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08981879
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08981879
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.08426617
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07595366
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07150561
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06986445
87SOX9_26525672_Chip-Seq_HEART_Mouse1.06729251
88EWS_26573619_Chip-Seq_HEK293_Human1.06384370
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05102031
90BRD4_25478319_ChIP-Seq_HGPS_Human1.04825657
91* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02625726
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00942351
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00865364
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00668069
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98524538
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98262697
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98242000
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98242000
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98242000
100* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97872329
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96608383
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96521179
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95406989
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95245883
105* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94235149
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93654786
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93172003
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93065813
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92916733
110ISL1_27105846_Chip-Seq_CPCs_Mouse0.92633382
111TP63_17297297_ChIP-ChIP_HaCaT_Human0.92443106
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92169294
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91958932
114* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91854212
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91658779
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91084831
117* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90250513
118KDM2B_26808549_Chip-Seq_DND41_Human0.90171340
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90090957
120* NANOG_16153702_ChIP-ChIP_HESCs_Human0.89887699
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89544149
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88846733
123GATA6_25053715_ChIP-Seq_YYC3_Human0.88788614
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88566652
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.87389812
126ATF3_27146783_Chip-Seq_COLON_Human0.87116885
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86966987
128TTF2_22483619_ChIP-Seq_HELA_Human0.86768901
129ZNF263_19887448_ChIP-Seq_K562_Human0.86154177
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84971902
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84428964
132* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83951994
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.83581595
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82668102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.13330241
2MP0010352_gastrointestinal_tract_polyps3.09243366
3MP0005076_abnormal_cell_differentiation2.90116648
4MP0010307_abnormal_tumor_latency2.51652131
5MP0010094_abnormal_chromosome_stability2.50856556
6MP0003111_abnormal_nucleus_morphology2.43677917
7MP0003941_abnormal_skin_development2.38527376
8MP0003077_abnormal_cell_cycle2.28745839
9MP0000537_abnormal_urethra_morphology2.28036639
10MP0002877_abnormal_melanocyte_morpholog2.18325652
11MP0003693_abnormal_embryo_hatching2.16601900
12MP0004957_abnormal_blastocyst_morpholog2.16412512
13MP0010030_abnormal_orbit_morphology2.14849320
14MP0003123_paternal_imprinting2.13278336
15MP0010234_abnormal_vibrissa_follicle2.12838257
16MP0003890_abnormal_embryonic-extraembry2.12617015
17MP0009697_abnormal_copulation2.05240994
18MP0008057_abnormal_DNA_replication2.02347291
19MP0001730_embryonic_growth_arrest1.96307317
20MP0009053_abnormal_anal_canal1.96236197
21MP0004197_abnormal_fetal_growth/weight/1.95609638
22MP0000569_abnormal_digit_pigmentation1.91517650
23MP0002084_abnormal_developmental_patter1.91163126
24MP0003121_genomic_imprinting1.90748622
25MP0000350_abnormal_cell_proliferation1.87808376
26MP0006054_spinal_hemorrhage1.79061564
27MP0001672_abnormal_embryogenesis/_devel1.77705078
28MP0005380_embryogenesis_phenotype1.77705078
29MP0008007_abnormal_cellular_replicative1.77482832
30MP0003300_gastrointestinal_ulcer1.68837756
31MP0002085_abnormal_embryonic_tissue1.68007737
32MP0001697_abnormal_embryo_size1.66990959
33MP0003984_embryonic_growth_retardation1.66459167
34MP0002088_abnormal_embryonic_growth/wei1.66014623
35MP0002086_abnormal_extraembryonic_tissu1.64530298
36MP0000428_abnormal_craniofacial_morphol1.59980078
37MP0000733_abnormal_muscle_development1.59972781
38MP0001293_anophthalmia1.55896202
39MP0003283_abnormal_digestive_organ1.53319675
40MP0003950_abnormal_plasma_membrane1.49024515
41MP0003937_abnormal_limbs/digits/tail_de1.48145627
42MP0001915_intracranial_hemorrhage1.44821997
43MP0005187_abnormal_penis_morphology1.44667612
44MP0009703_decreased_birth_body1.43835624
45MP0010368_abnormal_lymphatic_system1.40183512
46MP0002697_abnormal_eye_size1.39458294
47MP0004808_abnormal_hematopoietic_stem1.39118393
48MP0003935_abnormal_craniofacial_develop1.37090111
49MP0002092_abnormal_eye_morphology1.36666547
50MP0001849_ear_inflammation1.35288694
51MP0003567_abnormal_fetal_cardiomyocyte1.34400164
52MP0002080_prenatal_lethality1.34369799
53MP0006072_abnormal_retinal_apoptosis1.33996555
54MP0003119_abnormal_digestive_system1.31594984
55MP0009672_abnormal_birth_weight1.30766022
56MP0003566_abnormal_cell_adhesion1.28859927
57MP0008438_abnormal_cutaneous_collagen1.26969233
58MP0008058_abnormal_DNA_repair1.26928141
59MP0008932_abnormal_embryonic_tissue1.22998541
60MP0003115_abnormal_respiratory_system1.21816390
61MP0001879_abnormal_lymphatic_vessel1.19449696
62MP0001348_abnormal_lacrimal_gland1.18062803
63MP0005248_abnormal_Harderian_gland1.16392790
64MP0005409_darkened_coat_color1.14628471
65MP0000432_abnormal_head_morphology1.10824290
66MP0005197_abnormal_uvea_morphology1.10511749
67MP0003221_abnormal_cardiomyocyte_apopto1.10268266
68MP0005391_vision/eye_phenotype1.09949650
69MP0004264_abnormal_extraembryonic_tissu1.05481788
70MP0002111_abnormal_tail_morphology1.04477377
71MP0001286_abnormal_eye_development1.02959057
72MP0002925_abnormal_cardiovascular_devel1.02786205
73MP0005623_abnormal_meninges_morphology1.02480796
74MP0002396_abnormal_hematopoietic_system1.02164481
75MP0009250_abnormal_appendicular_skeleto1.01573774
76MP0004233_abnormal_muscle_weight1.00187859
77MP0003755_abnormal_palate_morphology0.99034378
78MP0000762_abnormal_tongue_morphology0.98714160
79MP0005023_abnormal_wound_healing0.96682777
80MP0008877_abnormal_DNA_methylation0.95686588
81MP0003942_abnormal_urinary_system0.94792045
82MP0005257_abnormal_intraocular_pressure0.94017384
83MP0000767_abnormal_smooth_muscle0.92695114
84MP0005220_abnormal_exocrine_pancreas0.91837447
85MP0000778_abnormal_nervous_system0.91552481
86MP0003385_abnormal_body_wall0.89128496
87MP0003011_delayed_dark_adaptation0.87613977
88MP0005253_abnormal_eye_physiology0.86820812
89MP0002932_abnormal_joint_morphology0.86520848
90MP0004185_abnormal_adipocyte_glucose0.85951825
91MP0003091_abnormal_cell_migration0.85897263
92MP0005621_abnormal_cell_physiology0.85610732
93MP0001661_extended_life_span0.84156777
94MP0009278_abnormal_bone_marrow0.84052032
95MP0001177_atelectasis0.84030760
96MP0000490_abnormal_crypts_of0.82393610
97MP0002653_abnormal_ependyma_morphology0.82166932
98MP0002114_abnormal_axial_skeleton0.81844565
99MP0001299_abnormal_eye_distance/0.81841510
100MP0010678_abnormal_skin_adnexa0.81771961
101MP0000534_abnormal_ureter_morphology0.81221219
102MP0003122_maternal_imprinting0.80892971
103MP0002081_perinatal_lethality0.80852667
104MP0005367_renal/urinary_system_phenotyp0.80754612
105MP0000516_abnormal_urinary_system0.80754612
106MP0002896_abnormal_bone_mineralization0.79748567
107MP0002116_abnormal_craniofacial_bone0.78760280
108MP0000579_abnormal_nail_morphology0.78206730
109MP0003861_abnormal_nervous_system0.78182011
110MP0004272_abnormal_basement_membrane0.78169003
111MP0002009_preneoplasia0.78154278
112MP0000462_abnormal_digestive_system0.78010650
113MP0002233_abnormal_nose_morphology0.77796736
114MP0004858_abnormal_nervous_system0.77752203
115MP0000383_abnormal_hair_follicle0.77463697
116MP0002234_abnormal_pharynx_morphology0.77331993
117MP0000313_abnormal_cell_death0.75217471
118MP0003315_abnormal_perineum_morphology0.74856946
119MP0002060_abnormal_skin_morphology0.73924940
120MP0000371_diluted_coat_color0.73868757
121MP0000266_abnormal_heart_morphology0.73159748
122MP0002177_abnormal_outer_ear0.72963151
123MP0001340_abnormal_eyelid_morphology0.72352131
124MP0005275_abnormal_skin_tensile0.70075734
125MP0002019_abnormal_tumor_incidence0.69064144

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.46406370
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46406370
3Volvulus (HP:0002580)3.44977235
4Premature rupture of membranes (HP:0001788)3.37416586
5Birth length less than 3rd percentile (HP:0003561)3.09654634
6Ependymoma (HP:0002888)2.89074474
7Increased nuchal translucency (HP:0010880)2.76222618
8Abnormality of the 4th metacarpal (HP:0010012)2.71042824
9Macroorchidism (HP:0000053)2.69496455
10Subacute progressive viral hepatitis (HP:0006572)2.69356657
11Abnormality of the astrocytes (HP:0100707)2.68487926
12Astrocytoma (HP:0009592)2.68487926
13Deviation of the thumb (HP:0009603)2.63388393
14Termporal pattern (HP:0011008)2.51650560
15Insidious onset (HP:0003587)2.51650560
16Breast hypoplasia (HP:0003187)2.51236415
17Asymmetry of the thorax (HP:0001555)2.48272719
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47463438
19Proximal placement of thumb (HP:0009623)2.46927299
20Heterotopia (HP:0002282)2.45760056
21Renal duplication (HP:0000075)2.44939996
22Colon cancer (HP:0003003)2.41345264
23Gastrointestinal carcinoma (HP:0002672)2.39140549
24Malignant gastrointestinal tract tumors (HP:0006749)2.39140549
25Hyperacusis (HP:0010780)2.35044435
26Shallow orbits (HP:0000586)2.33701352
27Cerebral aneurysm (HP:0004944)2.32355149
28Glioma (HP:0009733)2.29637937
29Chorioretinal atrophy (HP:0000533)2.29254133
30Medulloblastoma (HP:0002885)2.27856203
31Broad thumb (HP:0011304)2.21191839
32Neoplasm of the oral cavity (HP:0100649)2.20290605
33Arterial tortuosity (HP:0005116)2.19849789
34Biliary tract neoplasm (HP:0100574)2.19191827
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.19027550
36Renovascular hypertension (HP:0100817)2.18039472
37Missing ribs (HP:0000921)2.15417146
38Relative macrocephaly (HP:0004482)2.13303550
39Bowel diverticulosis (HP:0005222)2.12790410
40Coronal craniosynostosis (HP:0004440)2.12749769
41Long eyelashes (HP:0000527)2.12072725
42Truncal obesity (HP:0001956)2.11381428
43Abnormality of the fingertips (HP:0001211)2.09803066
44Vascular tortuosity (HP:0004948)2.08694544
45Deep philtrum (HP:0002002)2.07526556
46Posterior subcapsular cataract (HP:0007787)2.07472805
47Ankle contracture (HP:0006466)2.07408213
48Rhabdomyosarcoma (HP:0002859)2.06835586
49Pseudobulbar signs (HP:0002200)2.05993100
50Vertebral arch anomaly (HP:0008438)2.04802845
51Hypoplastic labia majora (HP:0000059)2.03823878
52Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.03662226
53Overgrowth (HP:0001548)2.03134832
54Selective tooth agenesis (HP:0001592)2.02340148
55Obsessive-compulsive behavior (HP:0000722)2.01298749
56Enlarged penis (HP:0000040)1.98541640
57Bladder diverticulum (HP:0000015)1.98294365
58Skull defect (HP:0001362)1.97360412
59High anterior hairline (HP:0009890)1.97111644
60Sandal gap (HP:0001852)1.97010730
61Osteolytic defects of the phalanges of the hand (HP:0009771)1.95725208
62Osteolytic defects of the hand bones (HP:0009699)1.95725208
63Elfin facies (HP:0004428)1.93774120
64Pendular nystagmus (HP:0012043)1.93619829
65Arnold-Chiari malformation (HP:0002308)1.92236291
66Aortic aneurysm (HP:0004942)1.92000927
67Increased density of long bones (HP:0006392)1.91840592
68Facial hemangioma (HP:0000329)1.90704236
69Transitional cell carcinoma of the bladder (HP:0006740)1.90505661
70Disproportionate tall stature (HP:0001519)1.87074457
71Bony spicule pigmentary retinopathy (HP:0007737)1.86967476
72Exostoses (HP:0100777)1.85695785
73Nephroblastoma (Wilms tumor) (HP:0002667)1.84654101
74Broad phalanges of the hand (HP:0009768)1.84429004
75Aortic dissection (HP:0002647)1.83973996
76Atrophic scars (HP:0001075)1.83471179
77Trigonocephaly (HP:0000243)1.83465845
78Ulnar bowing (HP:0003031)1.83306171
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.82844501
80Mitral valve prolapse (HP:0001634)1.82610323
81Rectal prolapse (HP:0002035)1.82167095
82Protrusio acetabuli (HP:0003179)1.82148128
83Ectopic kidney (HP:0000086)1.81837322
84Absent frontal sinuses (HP:0002688)1.81573062
85Abnormality of the labia majora (HP:0012881)1.81570116
86Neoplasm of striated muscle (HP:0009728)1.81158346
87Uterine leiomyosarcoma (HP:0002891)1.80789436
88Leiomyosarcoma (HP:0100243)1.80789436
89Uterine neoplasm (HP:0010784)1.80423002
90Prominent nose (HP:0000448)1.80328589
91Overriding aorta (HP:0002623)1.79961761
92Cutaneous melanoma (HP:0012056)1.78796343
93Overlapping toe (HP:0001845)1.78431230
94Embryonal renal neoplasm (HP:0011794)1.77829209
95Papillary thyroid carcinoma (HP:0002895)1.77729653
96Abnormality of the labia minora (HP:0012880)1.76766320
97Large earlobe (HP:0009748)1.75736764
98Cutis marmorata (HP:0000965)1.75136422
99Bladder neoplasm (HP:0009725)1.74924774
100Bladder carcinoma (HP:0002862)1.74924774
101Soft skin (HP:0000977)1.73621240
102Low anterior hairline (HP:0000294)1.72619145
103Wormian bones (HP:0002645)1.72191086
104Scotoma (HP:0000575)1.71543863
105Cortical dysplasia (HP:0002539)1.70630610
106Atresia of the external auditory canal (HP:0000413)1.70486318
107Anal stenosis (HP:0002025)1.70433293
108Abnormality of chromosome stability (HP:0003220)1.69930981
109High pitched voice (HP:0001620)1.69614608
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69364175
111Short humerus (HP:0005792)1.69125092
112Spastic diplegia (HP:0001264)1.69066102
113Pulmonic stenosis (HP:0001642)1.68796905
114Broad finger (HP:0001500)1.67937665
115Narrow palate (HP:0000189)1.67741466
116Ankyloglossia (HP:0010296)1.66843435
117Short nail (HP:0001799)1.66557524
118Hypopigmentation of the fundus (HP:0007894)1.65255460
119Chromsome breakage (HP:0040012)1.65226161
120Capillary hemangiomas (HP:0005306)1.65093350
121Impulsivity (HP:0100710)1.65002284
122Insomnia (HP:0100785)1.64043020
123Pelvic girdle muscle weakness (HP:0003749)1.63582189
124Hallux valgus (HP:0001822)1.63308750
125Smooth philtrum (HP:0000319)1.63006340
126Natal tooth (HP:0000695)1.62446604
127Deviation of the hallux (HP:0010051)1.62099848
128Hypoplasia of the maxilla (HP:0000327)1.61613363
129Cafe-au-lait spot (HP:0000957)1.61166139
130Wide anterior fontanel (HP:0000260)1.60190202
131Broad palm (HP:0001169)1.60099493
132Sparse lateral eyebrow (HP:0005338)1.58945314
133Broad phalanx (HP:0006009)1.58842930
134Abnormality of the calcaneus (HP:0008364)1.58832943
135Shoulder girdle muscle weakness (HP:0003547)1.58676368
136Spinal cord lesions (HP:0100561)1.58564988
137Syringomyelia (HP:0003396)1.58564988
138Persistence of primary teeth (HP:0006335)1.58377302
139Abnormality of oral frenula (HP:0000190)1.57999619
140Mesomelia (HP:0003027)1.57912488
141Aneurysm (HP:0002617)1.57603483
142Limb-girdle muscle weakness (HP:0003325)1.57391015
143Cubitus valgus (HP:0002967)1.57151041
144Neonatal short-limb short stature (HP:0008921)1.56932827
145Abnormality of the phalanges of the hallux (HP:0010057)1.56260509
146Acute myeloid leukemia (HP:0004808)1.55660652
147Flat cornea (HP:0007720)1.55521850
148Cystic hygroma (HP:0000476)1.54566544
149Broad ribs (HP:0000885)1.54371954
150Cutaneous syndactyly (HP:0012725)1.51346868
151Long foot (HP:0001833)1.51204879
152Thyroid carcinoma (HP:0002890)1.50772802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.89684995
2CDC73.49974387
3LATS12.99345309
4PKN22.99294142
5EEF2K2.95701413
6TRIB32.48691745
7NEK22.37921308
8PASK2.36344423
9SCYL22.24624126
10MAP3K102.23468169
11PDGFRA1.90086566
12PBK1.87540111
13BRD41.85393308
14CDK61.74333729
15TTK1.64835755
16TTN1.62203735
17PTK61.61593253
18NEK11.59168385
19STK31.58987927
20WEE11.58630915
21SRPK11.57382622
22NTRK11.54229113
23CAMK1D1.52718502
24RPS6KB21.52221249
25MKNK11.48704643
26CASK1.42815866
27MTOR1.40442553
28ATR1.40339606
29FLT31.38306514
30CDK41.31153859
31RIPK11.27243977
32MST1R1.25152564
33FRK1.24635808
34SIK11.24553916
35STK101.23333045
36CHEK11.23026387
37ALK1.22655340
38BCR1.20595298
39AKT31.19865375
40FGFR11.19400824
41AURKB1.18926407
42MAP3K81.17344236
43TGFBR11.17235337
44EPHA21.16436206
45PAK41.14503106
46MKNK21.14134927
47MAP3K61.12550376
48TSSK61.11344597
49BRSK21.11156479
50PLK31.10276817
51CAMK1G1.09288349
52MELK1.08854950
53RPS6KA41.08521559
54ATM1.08273521
55MAP3K41.05464564
56ACVR1B1.05423378
57PLK11.04359966
58CHEK21.03418096
59TAF11.02666955
60CDK70.97902413
61KSR10.95435866
62STK40.89422532
63PAK20.89305079
64TIE10.89246294
65FGFR30.89235863
66LRRK20.86555179
67PDGFRB0.85322006
68CDK20.84689270
69DDR20.82819557
70FGFR20.80479814
71ICK0.77511458
72ERBB30.77287489
73DYRK30.75553821
74BMPR1B0.74112506
75DYRK1B0.71384374
76CDK90.71150605
77CDK10.70448496
78KSR20.69816566
79CLK10.69018860
80MAP2K70.65912223
81CHUK0.65897510
82BUB10.65577448
83CDK80.65404249
84YES10.64885629
85ERBB20.63924700
86SMG10.62820445
87EIF2AK10.62432321
88PLK40.61288212
89STK240.61092312
90EPHB20.60298628
91CSNK1D0.59852450
92MET0.59828836
93PRKDC0.59137310
94STK38L0.57149429
95PTK20.56229505
96RET0.56153758
97MAP3K90.55831464
98HIPK20.54631466
99PIM10.54548338
100DMPK0.53898765
101NEK90.53710597
102MAPK140.52474690
103BMX0.52448150
104EIF2AK30.52154565
105LATS20.52052347
106RAF10.49081444
107WNK10.47870010
108CSNK1E0.47155642
109AKT10.47109809
110AKT20.46246604
111EIF2AK20.45611976
112BRSK10.45569539
113PLK20.43514948
114MAP3K20.42440733
115TLK10.40396219
116PRKD30.39532209
117CDK180.38610609
118BRAF0.38472976
119ZAK0.38315740
120SGK30.37977293
121ERBB40.37692880
122MAPK10.37680269
123RPS6KB10.37668574
124MOS0.37331342
125FGFR40.37211553
126TNIK0.37001475
127CDK150.36890953
128FER0.36557797
129GSK3B0.35075658
130PNCK0.34278123
131WNK30.32541502
132CSNK1A1L0.31571363

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.51743832
2RNA transport_Homo sapiens_hsa030132.41232551
3One carbon pool by folate_Homo sapiens_hsa006702.40367770
4DNA replication_Homo sapiens_hsa030302.12778277
5mRNA surveillance pathway_Homo sapiens_hsa030152.11449285
6Mismatch repair_Homo sapiens_hsa034302.00745467
7Spliceosome_Homo sapiens_hsa030402.00040699
8Systemic lupus erythematosus_Homo sapiens_hsa053221.95555627
9MicroRNAs in cancer_Homo sapiens_hsa052061.94483659
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88940331
11Lysine degradation_Homo sapiens_hsa003101.78393452
12Chronic myeloid leukemia_Homo sapiens_hsa052201.74059151
13Adherens junction_Homo sapiens_hsa045201.73030949
14Small cell lung cancer_Homo sapiens_hsa052221.71137227
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67446392
16mTOR signaling pathway_Homo sapiens_hsa041501.63715075
17Viral carcinogenesis_Homo sapiens_hsa052031.61795855
18p53 signaling pathway_Homo sapiens_hsa041151.60689414
19Non-homologous end-joining_Homo sapiens_hsa034501.58016744
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57720609
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53523939
22Hippo signaling pathway_Homo sapiens_hsa043901.44996711
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44542710
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40935744
25Selenocompound metabolism_Homo sapiens_hsa004501.40760787
26Basal cell carcinoma_Homo sapiens_hsa052171.38703798
27Colorectal cancer_Homo sapiens_hsa052101.36136912
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33639764
29Proteoglycans in cancer_Homo sapiens_hsa052051.32392744
30Phototransduction_Homo sapiens_hsa047441.29664341
31RNA degradation_Homo sapiens_hsa030181.29522201
32TGF-beta signaling pathway_Homo sapiens_hsa043501.28114342
33HTLV-I infection_Homo sapiens_hsa051661.27340408
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.27156291
35Endometrial cancer_Homo sapiens_hsa052131.24702781
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.24200357
37Notch signaling pathway_Homo sapiens_hsa043301.23696878
38Fanconi anemia pathway_Homo sapiens_hsa034601.19589933
39Nucleotide excision repair_Homo sapiens_hsa034201.19549588
40Bladder cancer_Homo sapiens_hsa052191.14494060
41Prostate cancer_Homo sapiens_hsa052151.13827378
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13677931
43Base excision repair_Homo sapiens_hsa034101.13542714
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11258945
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10873071
46Focal adhesion_Homo sapiens_hsa045101.08782908
47Pancreatic cancer_Homo sapiens_hsa052121.08148603
48Antigen processing and presentation_Homo sapiens_hsa046121.08020140
49Viral myocarditis_Homo sapiens_hsa054161.07578378
50ErbB signaling pathway_Homo sapiens_hsa040121.06098375
51Axon guidance_Homo sapiens_hsa043601.05450688
52Thyroid cancer_Homo sapiens_hsa052161.05291290
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02377053
54Alcoholism_Homo sapiens_hsa050340.98885452
55Non-small cell lung cancer_Homo sapiens_hsa052230.97561022
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95504733
57Oocyte meiosis_Homo sapiens_hsa041140.95161272
58Hedgehog signaling pathway_Homo sapiens_hsa043400.91389598
59Homologous recombination_Homo sapiens_hsa034400.89891200
60N-Glycan biosynthesis_Homo sapiens_hsa005100.88643164
61Herpes simplex infection_Homo sapiens_hsa051680.86400392
62Steroid biosynthesis_Homo sapiens_hsa001000.85855871
63Insulin resistance_Homo sapiens_hsa049310.85477704
64Pathways in cancer_Homo sapiens_hsa052000.83436560
65Gap junction_Homo sapiens_hsa045400.82823455
66ECM-receptor interaction_Homo sapiens_hsa045120.82582538
67FoxO signaling pathway_Homo sapiens_hsa040680.81445673
68Hepatitis B_Homo sapiens_hsa051610.79448820
69AMPK signaling pathway_Homo sapiens_hsa041520.77286346
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74421102
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74315471
72Inositol phosphate metabolism_Homo sapiens_hsa005620.74078821
73Renal cell carcinoma_Homo sapiens_hsa052110.73353728
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72991180
75Tight junction_Homo sapiens_hsa045300.72811071
76Epstein-Barr virus infection_Homo sapiens_hsa051690.72095377
77Wnt signaling pathway_Homo sapiens_hsa043100.71602746
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.71284248
79Glioma_Homo sapiens_hsa052140.70701178
80Prolactin signaling pathway_Homo sapiens_hsa049170.69351520
81Melanoma_Homo sapiens_hsa052180.67854938
82Dorso-ventral axis formation_Homo sapiens_hsa043200.67106914
83Dilated cardiomyopathy_Homo sapiens_hsa054140.66499301
84Type II diabetes mellitus_Homo sapiens_hsa049300.66444725
85Glucagon signaling pathway_Homo sapiens_hsa049220.66430655
86Melanogenesis_Homo sapiens_hsa049160.66382958
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65865090
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64302521
89Vitamin B6 metabolism_Homo sapiens_hsa007500.63592664
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61342975
91Insulin signaling pathway_Homo sapiens_hsa049100.61079442
92Nitrogen metabolism_Homo sapiens_hsa009100.60994120
93Choline metabolism in cancer_Homo sapiens_hsa052310.60637652
94Rap1 signaling pathway_Homo sapiens_hsa040150.60391296
95Apoptosis_Homo sapiens_hsa042100.60138296
96HIF-1 signaling pathway_Homo sapiens_hsa040660.59163261
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58225654
98Acute myeloid leukemia_Homo sapiens_hsa052210.57087322
99Toxoplasmosis_Homo sapiens_hsa051450.56549370
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56338321
101Legionellosis_Homo sapiens_hsa051340.55948566
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.54835697
103VEGF signaling pathway_Homo sapiens_hsa043700.54414486
104Protein digestion and absorption_Homo sapiens_hsa049740.53647588
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.52459595
106Biosynthesis of amino acids_Homo sapiens_hsa012300.50148327
107Shigellosis_Homo sapiens_hsa051310.49418498
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49275201
109Estrogen signaling pathway_Homo sapiens_hsa049150.46447915
110Thyroid hormone synthesis_Homo sapiens_hsa049180.46221120
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.45835124
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45180136
113Fatty acid biosynthesis_Homo sapiens_hsa000610.44329208
114Basal transcription factors_Homo sapiens_hsa030220.44278847
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44274024
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44043895
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43299343
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42345352
119Amoebiasis_Homo sapiens_hsa051460.41920586
120TNF signaling pathway_Homo sapiens_hsa046680.39405256
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38396883
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36042296
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35907924
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.35876308
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.33962952

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