TNPO1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)4.61162238
2establishment of protein localization to Golgi (GO:0072600)4.45392970
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.41414181
4DNA double-strand break processing (GO:0000729)4.29850703
5protein targeting to Golgi (GO:0000042)4.20859070
6regulation of mitotic spindle organization (GO:0060236)4.14325611
7negative regulation of translation, ncRNA-mediated (GO:0040033)4.11381058
8regulation of translation, ncRNA-mediated (GO:0045974)4.11381058
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.11381058
10positive regulation of T cell cytokine production (GO:0002726)4.04587952
11S-adenosylmethionine metabolic process (GO:0046500)3.93320047
12neural tube formation (GO:0001841)3.91992730
13hindbrain development (GO:0030902)3.90753607
14alkaloid metabolic process (GO:0009820)3.89576236
15response to pheromone (GO:0019236)3.83824507
16protein localization to Golgi apparatus (GO:0034067)3.79136231
17keratinocyte development (GO:0003334)3.77302163
18indolalkylamine metabolic process (GO:0006586)3.73269511
19centriole replication (GO:0007099)3.65623579
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64634367
21regulation of mitotic spindle checkpoint (GO:1903504)3.58617087
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58617087
23RNA destabilization (GO:0050779)3.54936876
24fucose catabolic process (GO:0019317)3.48102436
25L-fucose metabolic process (GO:0042354)3.48102436
26L-fucose catabolic process (GO:0042355)3.48102436
27somite development (GO:0061053)3.48093846
28epithelial cilium movement (GO:0003351)3.42867994
29acrosome reaction (GO:0007340)3.42807157
30axoneme assembly (GO:0035082)3.42521817
31sperm motility (GO:0030317)3.41452454
32regulation of hexokinase activity (GO:1903299)3.39930729
33regulation of glucokinase activity (GO:0033131)3.39930729
34DNA packaging (GO:0006323)3.39649847
35protein polyglutamylation (GO:0018095)3.37775758
36neuron remodeling (GO:0016322)3.36308361
37regulation of DNA endoreduplication (GO:0032875)3.36174715
38regulation of meiosis I (GO:0060631)3.35223452
39central nervous system projection neuron axonogenesis (GO:0021952)3.33205349
40left/right axis specification (GO:0070986)3.31807570
41regulation of T cell chemotaxis (GO:0010819)3.31691213
42positive regulation of T cell chemotaxis (GO:0010820)3.31691213
43negative regulation of translational initiation (GO:0045947)3.31090430
44tryptophan catabolic process (GO:0006569)3.23550850
45indole-containing compound catabolic process (GO:0042436)3.23550850
46indolalkylamine catabolic process (GO:0046218)3.23550850
47microtubule depolymerization (GO:0007019)3.19475868
48limb bud formation (GO:0060174)3.13507774
49piRNA metabolic process (GO:0034587)3.11869863
50cilium morphogenesis (GO:0060271)3.11243850
51DNA damage response, detection of DNA damage (GO:0042769)3.08941180
52protein K6-linked ubiquitination (GO:0085020)3.08562383
53head development (GO:0060322)3.08019235
54single strand break repair (GO:0000012)3.07161192
55inositol phosphate dephosphorylation (GO:0046855)2.95078683
56phosphorylated carbohydrate dephosphorylation (GO:0046838)2.95078683
57intra-Golgi vesicle-mediated transport (GO:0006891)2.94785925
58seminiferous tubule development (GO:0072520)2.92257427
59regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.90045407
60positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.90045407
61inositol phosphate catabolic process (GO:0071545)2.89279405
62regulation of cilium movement (GO:0003352)2.86150715
63protein K63-linked deubiquitination (GO:0070536)2.85163146
64central nervous system neuron axonogenesis (GO:0021955)2.84996261
65synapsis (GO:0007129)2.84696137
66microtubule polymerization or depolymerization (GO:0031109)2.83646729
67detection of light stimulus involved in visual perception (GO:0050908)2.82902484
68detection of light stimulus involved in sensory perception (GO:0050962)2.82902484
69pituitary gland development (GO:0021983)2.82392970
70intestinal epithelial cell development (GO:0060576)2.80738961
71cilium or flagellum-dependent cell motility (GO:0001539)2.80540712
72chromatin remodeling at centromere (GO:0031055)2.79651629
73regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79230501
74nucleotide transmembrane transport (GO:1901679)2.78150406
75regulation of centriole replication (GO:0046599)2.76077177
76inositol metabolic process (GO:0006020)2.74392397
77synaptic transmission, cholinergic (GO:0007271)2.73894601
78recombinational repair (GO:0000725)2.73658424
79retina layer formation (GO:0010842)2.72982093
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72618416
81regulation of spindle organization (GO:0090224)2.71099733
82cornea development in camera-type eye (GO:0061303)2.71014059
83respiratory chain complex IV assembly (GO:0008535)2.70279211
84regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.69095699
85positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.69095699
86double-strand break repair via homologous recombination (GO:0000724)2.66025160
87polyol catabolic process (GO:0046174)2.65546668
88protein K11-linked deubiquitination (GO:0035871)2.65136452
89pancreas development (GO:0031016)2.64599431
90cilium movement (GO:0003341)2.63457533
91DNA replication checkpoint (GO:0000076)2.63230666
92positive regulation of mRNA catabolic process (GO:0061014)2.62733581
93protein K48-linked deubiquitination (GO:0071108)2.62675697
94DNA methylation involved in gamete generation (GO:0043046)2.62431399
95somite rostral/caudal axis specification (GO:0032525)2.61840414
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.60936184
97positive regulation of mRNA processing (GO:0050685)2.57621429
98positive regulation of transforming growth factor beta production (GO:0071636)2.56158584
99neuron maturation (GO:0042551)2.53287659
100cilium organization (GO:0044782)2.50712106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.87511029
2GBX2_23144817_ChIP-Seq_PC3_Human2.95700255
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.85608979
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82668003
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74724792
6TAF15_26573619_Chip-Seq_HEK293_Human2.67396499
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67274164
8VDR_22108803_ChIP-Seq_LS180_Human2.57398209
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53839426
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.53142221
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51416822
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45813882
13FUS_26573619_Chip-Seq_HEK293_Human2.39059354
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37766512
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27107465
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26039447
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23459169
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19702396
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18574828
20P300_19829295_ChIP-Seq_ESCs_Human2.18317965
21IGF1R_20145208_ChIP-Seq_DFB_Human2.15001865
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95465678
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.95354665
24CBP_20019798_ChIP-Seq_JUKART_Human1.95354665
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93396591
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86013655
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.84349859
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77502946
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75032501
30EWS_26573619_Chip-Seq_HEK293_Human1.72467941
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.72432964
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70105757
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69323134
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.69122356
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68342345
36SMAD4_21799915_ChIP-Seq_A2780_Human1.64562759
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63729712
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57512380
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.57214936
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.50873971
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49400703
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49020454
43STAT3_23295773_ChIP-Seq_U87_Human1.47965564
44TCF4_22108803_ChIP-Seq_LS180_Human1.47563744
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46981792
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43469397
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43259709
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.43237362
49ER_23166858_ChIP-Seq_MCF-7_Human1.42963416
50BCAT_22108803_ChIP-Seq_LS180_Human1.42659476
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41710211
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.41304298
53P53_22387025_ChIP-Seq_ESCs_Mouse1.40880835
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39533530
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39533530
56AR_25329375_ChIP-Seq_VCAP_Human1.36294292
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34313369
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34048840
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32777820
60VDR_23849224_ChIP-Seq_CD4+_Human1.32502630
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.31891141
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29394614
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28984622
64P300_18555785_Chip-Seq_ESCs_Mouse1.28891889
65TCF4_23295773_ChIP-Seq_U87_Human1.27785628
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26637383
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26200958
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26043686
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.22643812
70SOX2_19829295_ChIP-Seq_ESCs_Human1.21810699
71NANOG_19829295_ChIP-Seq_ESCs_Human1.21810699
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21695748
73RUNX2_22187159_ChIP-Seq_PCA_Human1.21593571
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.19367055
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18763731
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.18534504
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18416634
78ELK1_19687146_ChIP-ChIP_HELA_Human1.17716155
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.17544621
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17523532
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.16918671
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13720965
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.13183164
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12521213
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.11443006
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10882845
87CTCF_18555785_Chip-Seq_ESCs_Mouse1.09954200
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07500691
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06708236
90RNF2_27304074_Chip-Seq_NSC_Mouse1.06388066
91NCOR_22424771_ChIP-Seq_293T_Human1.06262590
92TP53_22573176_ChIP-Seq_HFKS_Human1.04836445
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04607818
94FOXH1_21741376_ChIP-Seq_EPCs_Human1.02767090
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.02730916
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02540714
97IRF1_19129219_ChIP-ChIP_H3396_Human0.99813829
98KLF4_18555785_Chip-Seq_ESCs_Mouse0.97253985
99PU1_27457419_Chip-Seq_LIVER_Mouse0.96267713
100ETV1_20927104_ChIP-Seq_GIST48_Human0.96260128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.34733340
2MP0000569_abnormal_digit_pigmentation3.15545788
3MP0003890_abnormal_embryonic-extraembry3.04519504
4MP0001919_abnormal_reproductive_system2.98662570
5MP0002160_abnormal_reproductive_system2.95347059
6MP0003787_abnormal_imprinting2.86970406
7MP0006292_abnormal_olfactory_placode2.78585601
8MP0002102_abnormal_ear_morphology2.58385226
9MP0003136_yellow_coat_color2.32020402
10MP0003880_abnormal_central_pattern2.23330662
11MP0003646_muscle_fatigue2.15399244
12MP0001727_abnormal_embryo_implantation2.12024248
13MP0005389_reproductive_system_phenotype2.11539088
14MP0003121_genomic_imprinting2.07965357
15MP0005551_abnormal_eye_electrophysiolog2.07615116
16MP0002736_abnormal_nociception_after2.07529257
17MP0001188_hyperpigmentation1.99967048
18MP0001968_abnormal_touch/_nociception1.93528040
19MP0009697_abnormal_copulation1.93424263
20MP0005410_abnormal_fertilization1.84004542
21MP0003693_abnormal_embryo_hatching1.83651383
22MP0001486_abnormal_startle_reflex1.82510865
23MP0005253_abnormal_eye_physiology1.78588171
24MP0000647_abnormal_sebaceous_gland1.78265195
25MP0006072_abnormal_retinal_apoptosis1.77569577
26MP0000015_abnormal_ear_pigmentation1.74896971
27MP0004133_heterotaxia1.68650957
28MP0001529_abnormal_vocalization1.64358385
29MP0000778_abnormal_nervous_system1.62682444
30MP0004147_increased_porphyrin_level1.62007622
31MP0003698_abnormal_male_reproductive1.60165623
32MP0004142_abnormal_muscle_tone1.60152520
33MP0004924_abnormal_behavior1.53233581
34MP0005386_behavior/neurological_phenoty1.53233581
35MP0000372_irregular_coat_pigmentation1.48563253
36MP0005248_abnormal_Harderian_gland1.47753261
37MP0001929_abnormal_gametogenesis1.46378182
38MP0003195_calcinosis1.44016306
39MP0000427_abnormal_hair_cycle1.39683382
40MP0005075_abnormal_melanosome_morpholog1.38440787
41MP0003718_maternal_effect1.37191702
42MP0004134_abnormal_chest_morphology1.37091000
43MP0000631_abnormal_neuroendocrine_gland1.30624723
44MP0009745_abnormal_behavioral_response1.29577142
45MP0008058_abnormal_DNA_repair1.26352925
46MP0008057_abnormal_DNA_replication1.25057171
47MP0002184_abnormal_innervation1.24548579
48MP0000049_abnormal_middle_ear1.19010088
49MP0003122_maternal_imprinting1.18394321
50MP0002272_abnormal_nervous_system1.12959046
51MP0005645_abnormal_hypothalamus_physiol1.12063136
52MP0002210_abnormal_sex_determination1.11656761
53MP0002735_abnormal_chemical_nociception1.10315238
54MP0004381_abnormal_hair_follicle1.10045137
55MP0003119_abnormal_digestive_system1.07255433
56MP0003878_abnormal_ear_physiology1.06198616
57MP0005377_hearing/vestibular/ear_phenot1.06198616
58MP0002277_abnormal_respiratory_mucosa1.05491826
59MP0000383_abnormal_hair_follicle1.04394835
60MP0005367_renal/urinary_system_phenotyp1.03776954
61MP0000516_abnormal_urinary_system1.03776954
62MP0000955_abnormal_spinal_cord1.02603642
63MP0008789_abnormal_olfactory_epithelium1.02489341
64MP0001984_abnormal_olfaction0.98315931
65MP0001485_abnormal_pinna_reflex0.97547902
66MP0009046_muscle_twitch0.97535462
67MP0000653_abnormal_sex_gland0.96821458
68MP0006276_abnormal_autonomic_nervous0.96727610
69MP0001286_abnormal_eye_development0.96643676
70MP0008872_abnormal_physiological_respon0.96312443
71MP0002837_dystrophic_cardiac_calcinosis0.95641411
72MP0000613_abnormal_salivary_gland0.93467428
73MP0003045_fibrosis0.93308713
74MP0001145_abnormal_male_reproductive0.93249101
75MP0003755_abnormal_palate_morphology0.91645567
76MP0002752_abnormal_somatic_nervous0.91186095
77MP0002067_abnormal_sensory_capabilities0.90273421
78MP0002095_abnormal_skin_pigmentation0.90092113
79MP0001873_stomach_inflammation0.88070120
80MP0001293_anophthalmia0.87774836
81MP0002557_abnormal_social/conspecific_i0.87631151
82MP0005395_other_phenotype0.86653653
83MP0002938_white_spotting0.86356621
84MP0005670_abnormal_white_adipose0.84274700
85MP0005167_abnormal_blood-brain_barrier0.82904300
86MP0001324_abnormal_eye_pigmentation0.81507981
87MP0005195_abnormal_posterior_eye0.79678307
88MP0004215_abnormal_myocardial_fiber0.76737315
89MP0002733_abnormal_thermal_nociception0.75698022
90MP0002572_abnormal_emotion/affect_behav0.75537022
91MP0002638_abnormal_pupillary_reflex0.75326163
92MP0010094_abnormal_chromosome_stability0.74561172
93MP0005310_abnormal_salivary_gland0.73173314
94MP0003635_abnormal_synaptic_transmissio0.71310580
95MP0005174_abnormal_tail_pigmentation0.70065070
96MP0002161_abnormal_fertility/fecundity0.69744146
97MP0003861_abnormal_nervous_system0.68866392
98MP0003936_abnormal_reproductive_system0.68022650
99MP0006035_abnormal_mitochondrial_morpho0.67745507
100MP0002168_other_aberrant_phenotype0.67745388

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.37894909
2Hyperinsulinemic hypoglycemia (HP:0000825)3.87742859
3Abnormality of midbrain morphology (HP:0002418)3.79003022
4Molar tooth sign on MRI (HP:0002419)3.79003022
5Chronic hepatic failure (HP:0100626)3.19206326
6Nephronophthisis (HP:0000090)3.18442448
7Abnormality of the renal cortex (HP:0011035)3.05280968
8Hypoplastic ischia (HP:0003175)3.04355588
9Renal cortical cysts (HP:0000803)3.04275631
10Absent/shortened dynein arms (HP:0200106)3.03374990
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.03374990
12Menstrual irregularities (HP:0000858)2.95102409
13Pancreatic cysts (HP:0001737)2.92726233
14Lissencephaly (HP:0001339)2.87928664
15Congenital stationary night blindness (HP:0007642)2.78684121
16Exertional dyspnea (HP:0002875)2.78160633
17Cerebral hypomyelination (HP:0006808)2.76134204
18Supernumerary spleens (HP:0009799)2.75200845
19Abnormality of the ischium (HP:0003174)2.74318841
20Abnormality of the renal medulla (HP:0100957)2.73649736
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.69477701
22Tubulointerstitial nephritis (HP:0001970)2.62083627
23Abnormality of macular pigmentation (HP:0008002)2.62018229
24Heterotopia (HP:0002282)2.49972752
25Intestinal atresia (HP:0011100)2.49810653
26Hypothermia (HP:0002045)2.46084284
27True hermaphroditism (HP:0010459)2.41384636
28Pancreatic fibrosis (HP:0100732)2.34834810
29Pachygyria (HP:0001302)2.33024641
30Volvulus (HP:0002580)2.31099494
31Retrobulbar optic neuritis (HP:0100654)2.28107615
32Optic neuritis (HP:0100653)2.28107615
33Limb dystonia (HP:0002451)2.26712277
34Medial flaring of the eyebrow (HP:0010747)2.25571567
35Methylmalonic acidemia (HP:0002912)2.19837808
36Abnormality of placental membranes (HP:0011409)2.19006321
37Amniotic constriction ring (HP:0009775)2.19006321
38Attenuation of retinal blood vessels (HP:0007843)2.18579003
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.15181846
40Growth hormone deficiency (HP:0000824)2.13805973
41Colon cancer (HP:0003003)2.13801358
42Type 2 muscle fiber atrophy (HP:0003554)2.12136199
43Horizontal nystagmus (HP:0000666)2.11163721
44Patellar aplasia (HP:0006443)2.09667908
45Hyperlipoproteinemia (HP:0010980)2.09255140
46Abnormal respiratory epithelium morphology (HP:0012253)2.07623773
47Abnormal respiratory motile cilium morphology (HP:0005938)2.07623773
48Abnormal ciliary motility (HP:0012262)2.06341218
49Hepatic necrosis (HP:0002605)2.03414743
50Anophthalmia (HP:0000528)2.02126649
51Optic nerve hypoplasia (HP:0000609)2.01770087
52Wide nose (HP:0000445)2.01550291
53Truncal obesity (HP:0001956)1.99957909
54Type II lissencephaly (HP:0007260)1.98967835
55Fetal akinesia sequence (HP:0001989)1.94651742
56Cystic hygroma (HP:0000476)1.94391819
57Aplasia/Hypoplasia of the patella (HP:0006498)1.94291823
58Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92589358
59Nephrogenic diabetes insipidus (HP:0009806)1.92466752
60Sloping forehead (HP:0000340)1.90948620
61Gonadotropin excess (HP:0000837)1.90397798
62Ectopic kidney (HP:0000086)1.89795413
63Hepatocellular necrosis (HP:0001404)1.89603340
64Hyperventilation (HP:0002883)1.88951160
65Intention tremor (HP:0002080)1.88476076
66Fair hair (HP:0002286)1.88269956
67Narrow forehead (HP:0000341)1.87462237
68Abnormality of chromosome stability (HP:0003220)1.86305708
69Curly hair (HP:0002212)1.85833931
70Short tibia (HP:0005736)1.85581395
71Gait imbalance (HP:0002141)1.81000479
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78411008
73Postaxial hand polydactyly (HP:0001162)1.76026578
74Neoplasm of the oral cavity (HP:0100649)1.74833247
75Congenital primary aphakia (HP:0007707)1.74581824
76Albinism (HP:0001022)1.74295302
77Prominent nasal bridge (HP:0000426)1.73223477
78Abnormal hair whorl (HP:0010721)1.72939734
79Oculomotor apraxia (HP:0000657)1.72633856
80Thickened helices (HP:0000391)1.72060237
81Focal motor seizures (HP:0011153)1.71700229
82Delayed puberty (HP:0000823)1.71337211
83Action tremor (HP:0002345)1.71012926
84Gaze-evoked nystagmus (HP:0000640)1.69512914
85Hypogonadotrophic hypogonadism (HP:0000044)1.69508413
86Epidermoid cyst (HP:0200040)1.69292904
87Hip contracture (HP:0003273)1.68736437
88Broad-based gait (HP:0002136)1.68619396
89Inappropriate behavior (HP:0000719)1.68558605
90Median cleft lip (HP:0000161)1.67813290
91Postaxial foot polydactyly (HP:0001830)1.67682816
92Central scotoma (HP:0000603)1.66515427
93Methylmalonic aciduria (HP:0012120)1.66200600
94Partial agenesis of the corpus callosum (HP:0001338)1.65884774
95Small hand (HP:0200055)1.65814102
96Cerebellar dysplasia (HP:0007033)1.64930298
97Increased CSF lactate (HP:0002490)1.64247769
98Polydipsia (HP:0001959)1.63925193
99Abnormal drinking behavior (HP:0030082)1.63925193
100CNS hypomyelination (HP:0003429)1.63720979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.01300886
2PNCK4.84044609
3NLK3.73811972
4AKT33.62835072
5TRIM283.37243430
6PLK43.30943600
7FRK3.07221324
8GRK12.89454662
9EPHA42.72641096
10CDK92.55217240
11ACVR1B2.51018650
12BMPR1B2.22748477
13EPHA32.01264811
14MAP4K21.80271933
15MKNK21.68089109
16WNK31.56592768
17WEE11.54677093
18TXK1.53171537
19TTK1.49167038
20EIF2AK31.46092349
21PLK21.44918244
22BRAF1.34108199
23DYRK21.32966138
24INSRR1.28258444
25BUB11.25651781
26EIF2AK11.21734841
27MARK11.20721938
28PINK11.18944874
29PIK3CG1.17161058
30STK38L1.11867354
31CAMK1G1.11637005
32BCR1.09478123
33DYRK31.08645403
34VRK11.05682934
35MAPK131.03105309
36PRKCE1.00229782
37PRKCG0.97647728
38BRD40.95324354
39NEK90.92971811
40BRSK20.90437582
41CDC70.88599324
42MAP3K40.85441194
43NUAK10.83398868
44TGFBR10.82591907
45PLK10.80404380
46MAP2K70.79345280
47ERBB30.74812327
48MKNK10.74312993
49CDK190.73306361
50PLK30.72909260
51CDK80.71572004
52SRPK10.70210834
53MAP3K120.70057768
54STK390.69597174
55ZAK0.68044740
56ADRBK20.61662558
57PTK2B0.61052517
58SGK20.60200942
59MST40.59158762
60TLK10.56875694
61DYRK1A0.55136971
62CAMKK20.53756868
63OXSR10.53665422
64NTRK20.52881935
65EPHB20.50909881
66CSNK1G10.50600638
67OBSCN0.47824269
68ATR0.47736652
69CSNK1G20.46130178
70CASK0.45786328
71TEC0.44481682
72FGFR20.42903006
73ATM0.42187079
74CSNK1G30.40690431
75MELK0.39991894
76ADRBK10.38508175
77CSNK1E0.35165846
78PRKG10.34673219
79PIK3CA0.32997455
80MINK10.32579956
81ZAP700.31807274
82PASK0.31456870
83MAPK150.31300996
84WNK40.31183234
85CSNK1A1L0.31004264
86CAMK2A0.29806726
87GRK70.28660520
88NTRK30.28383420
89CHUK0.27912599
90MARK30.25128809
91CSNK2A10.24931125
92SGK2230.23888579
93SGK4940.23888579
94PRKCZ0.23080675
95PKN10.21821878
96PAK30.21200662
97CAMK40.20910042
98FER0.20762982
99NEK60.20678841
100IGF1R0.18666377

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.53272208
2RNA polymerase_Homo sapiens_hsa030202.98481554
3Basal transcription factors_Homo sapiens_hsa030222.82259759
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78905297
5Oxidative phosphorylation_Homo sapiens_hsa001902.42997565
6Selenocompound metabolism_Homo sapiens_hsa004502.31718778
7Protein export_Homo sapiens_hsa030602.26103115
8RNA degradation_Homo sapiens_hsa030182.19763121
9Fanconi anemia pathway_Homo sapiens_hsa034602.07945319
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03591680
11Tryptophan metabolism_Homo sapiens_hsa003802.01942065
12RNA transport_Homo sapiens_hsa030131.96153289
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92155667
14Homologous recombination_Homo sapiens_hsa034401.81544882
15Propanoate metabolism_Homo sapiens_hsa006401.81069848
16Basal cell carcinoma_Homo sapiens_hsa052171.80920494
17Collecting duct acid secretion_Homo sapiens_hsa049661.74561885
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72816116
19Butanoate metabolism_Homo sapiens_hsa006501.70426910
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69854589
21Steroid biosynthesis_Homo sapiens_hsa001001.68985342
22Phototransduction_Homo sapiens_hsa047441.66455291
23Nitrogen metabolism_Homo sapiens_hsa009101.62470565
24Parkinsons disease_Homo sapiens_hsa050121.59343309
25Huntingtons disease_Homo sapiens_hsa050161.56737359
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48334176
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40878265
28Nicotine addiction_Homo sapiens_hsa050331.35772564
29Taste transduction_Homo sapiens_hsa047421.31254472
30Regulation of autophagy_Homo sapiens_hsa041401.29664000
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26873200
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22710219
33Olfactory transduction_Homo sapiens_hsa047401.21656251
34Nucleotide excision repair_Homo sapiens_hsa034201.14798545
35Hedgehog signaling pathway_Homo sapiens_hsa043401.11684149
36Lysine degradation_Homo sapiens_hsa003101.10931937
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05757343
38Synaptic vesicle cycle_Homo sapiens_hsa047211.05648076
39Cardiac muscle contraction_Homo sapiens_hsa042601.05512230
40Alzheimers disease_Homo sapiens_hsa050101.05212829
41Hippo signaling pathway_Homo sapiens_hsa043901.03536103
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97526574
43ABC transporters_Homo sapiens_hsa020100.95537892
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.95253389
45Linoleic acid metabolism_Homo sapiens_hsa005910.92527034
46Caffeine metabolism_Homo sapiens_hsa002320.91510019
47Amphetamine addiction_Homo sapiens_hsa050310.88985347
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87760712
49Circadian rhythm_Homo sapiens_hsa047100.86697549
50Insulin secretion_Homo sapiens_hsa049110.86657796
51Mismatch repair_Homo sapiens_hsa034300.81892609
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80840530
53Chemical carcinogenesis_Homo sapiens_hsa052040.80184027
54Tight junction_Homo sapiens_hsa045300.79136943
55beta-Alanine metabolism_Homo sapiens_hsa004100.78662274
56Sulfur metabolism_Homo sapiens_hsa009200.76884690
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75858769
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74746111
59Spliceosome_Homo sapiens_hsa030400.71560456
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71421186
61Peroxisome_Homo sapiens_hsa041460.70754861
62Wnt signaling pathway_Homo sapiens_hsa043100.68950289
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68828871
64Histidine metabolism_Homo sapiens_hsa003400.67845578
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.66287240
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65829846
67Cocaine addiction_Homo sapiens_hsa050300.64781359
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64628478
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62354953
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61457856
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58952703
72Fatty acid degradation_Homo sapiens_hsa000710.58189515
73Pyruvate metabolism_Homo sapiens_hsa006200.58121069
74Retinol metabolism_Homo sapiens_hsa008300.57945916
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.57893398
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56499068
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56286056
78Fatty acid biosynthesis_Homo sapiens_hsa000610.54565317
79Ether lipid metabolism_Homo sapiens_hsa005650.54343752
80Proteasome_Homo sapiens_hsa030500.53284009
81Purine metabolism_Homo sapiens_hsa002300.51755142
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.49387582
83Arginine and proline metabolism_Homo sapiens_hsa003300.48506127
84Serotonergic synapse_Homo sapiens_hsa047260.48134207
85Dopaminergic synapse_Homo sapiens_hsa047280.48095544
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.46935507
87Vibrio cholerae infection_Homo sapiens_hsa051100.46576970
88Glycerolipid metabolism_Homo sapiens_hsa005610.46009951
89Fatty acid metabolism_Homo sapiens_hsa012120.45864084
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44964590
91Metabolic pathways_Homo sapiens_hsa011000.44851797
92Glutamatergic synapse_Homo sapiens_hsa047240.44032132
93TGF-beta signaling pathway_Homo sapiens_hsa043500.43853136
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43666257
95Vitamin B6 metabolism_Homo sapiens_hsa007500.39790591
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38376470
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38120734
98Melanogenesis_Homo sapiens_hsa049160.37354933
99Colorectal cancer_Homo sapiens_hsa052100.34181170
100Salivary secretion_Homo sapiens_hsa049700.33969316

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