TNPO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.93584075
2multicellular organism reproduction (GO:0032504)9.29169309
3plasma membrane fusion (GO:0045026)8.41847809
4cilium or flagellum-dependent cell motility (GO:0001539)8.31992726
5reproduction (GO:0000003)7.99153766
6sperm-egg recognition (GO:0035036)7.98052153
7cell-cell recognition (GO:0009988)7.22929369
8binding of sperm to zona pellucida (GO:0007339)6.00204666
9spermatid nucleus differentiation (GO:0007289)5.76664611
10sperm motility (GO:0030317)5.71566480
11acrosome reaction (GO:0007340)5.03375033
12motile cilium assembly (GO:0044458)5.02065760
13male meiosis (GO:0007140)4.88693417
14axonemal dynein complex assembly (GO:0070286)4.74153330
15epithelial cilium movement (GO:0003351)4.72874658
16single fertilization (GO:0007338)4.62567346
17synaptonemal complex assembly (GO:0007130)4.61554275
18spermatid development (GO:0007286)4.57003872
19peptidyl-lysine dimethylation (GO:0018027)4.54902225
20sperm capacitation (GO:0048240)4.53548797
21cilium movement (GO:0003341)4.32373869
22synaptonemal complex organization (GO:0070193)4.25949607
23cell recognition (GO:0008037)4.20057741
24cerebellar granule cell differentiation (GO:0021707)4.19488618
25cellular potassium ion homeostasis (GO:0030007)4.16228467
26calcium ion-dependent exocytosis (GO:0017156)4.02156339
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89088861
28pre-miRNA processing (GO:0031054)3.85968364
29regulation of synaptic vesicle exocytosis (GO:2000300)3.76507493
30layer formation in cerebral cortex (GO:0021819)3.73303306
31synaptic vesicle exocytosis (GO:0016079)3.71980967
32monoubiquitinated protein deubiquitination (GO:0035520)3.68975593
33ventricular system development (GO:0021591)3.56635028
34regulation of neuronal synaptic plasticity (GO:0048168)3.52291664
35fertilization (GO:0009566)3.51876286
36sexual reproduction (GO:0019953)3.44099367
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.36463477
38regulation of NFAT protein import into nucleus (GO:0051532)3.34456844
39macroautophagy (GO:0016236)3.33450102
40microtubule severing (GO:0051013)3.31913153
41postsynaptic membrane organization (GO:0001941)3.31343781
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28671154
43synaptic vesicle maturation (GO:0016188)3.28065417
44neurotransmitter secretion (GO:0007269)3.20382211
45nuclear pore complex assembly (GO:0051292)3.14797602
46cell communication by electrical coupling (GO:0010644)3.10118965
47cellular process involved in reproduction in multicellular organism (GO:0022412)3.08550558
48amino acid import (GO:0043090)3.08193365
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05713076
50mitochondrion transport along microtubule (GO:0047497)3.05713076
51peptidyl-threonine dephosphorylation (GO:0035970)3.05684753
52NLS-bearing protein import into nucleus (GO:0006607)3.05571185
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03700741
54neuronal ion channel clustering (GO:0045161)3.02748165
55adherens junction assembly (GO:0034333)3.02366201
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01175413
57microtubule depolymerization (GO:0007019)3.01093823
58piRNA metabolic process (GO:0034587)3.00475338
59establishment of mitochondrion localization (GO:0051654)2.99891795
60regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99637857
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98567017
62ionotropic glutamate receptor signaling pathway (GO:0035235)2.98411298
63locomotory exploration behavior (GO:0035641)2.98195174
64negative regulation of organelle assembly (GO:1902116)2.96422334
65regulation of synaptic vesicle transport (GO:1902803)2.94002327
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93514180
67semaphorin-plexin signaling pathway (GO:0071526)2.89537291
68chromosome organization involved in meiosis (GO:0070192)2.87499189
69cytoplasmic mRNA processing body assembly (GO:0033962)2.87008043
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.85711213
71potassium ion homeostasis (GO:0055075)2.84421491
72synaptic vesicle endocytosis (GO:0048488)2.84230257
73negative regulation of dendrite morphogenesis (GO:0050774)2.79425434
74cell-substrate adherens junction assembly (GO:0007045)2.78599457
75focal adhesion assembly (GO:0048041)2.78599457
76regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76178283
77regulation of synaptic plasticity (GO:0048167)2.75562174
78regulation of synapse maturation (GO:0090128)2.75225535
79regulation of translational termination (GO:0006449)2.72993720
80protein K11-linked deubiquitination (GO:0035871)2.71304892
81L-amino acid import (GO:0043092)2.70642450
82membrane depolarization during action potential (GO:0086010)2.70245022
83mating behavior (GO:0007617)2.70117572
84regulation of centriole replication (GO:0046599)2.69806754
85protein localization to synapse (GO:0035418)2.68678698
86activation of Rac GTPase activity (GO:0032863)2.67390402
87germ cell development (GO:0007281)2.65211359
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64657680
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.63791073
90dendritic spine organization (GO:0097061)2.62700023
91regulation of cilium movement (GO:0003352)2.62112736
92dopamine receptor signaling pathway (GO:0007212)2.61847494
93spermatogenesis (GO:0007283)2.59480188
94male gamete generation (GO:0048232)2.57974159
95glucocorticoid receptor signaling pathway (GO:0042921)2.57035781
96cell migration in hindbrain (GO:0021535)2.56783723
97negative regulation of microtubule polymerization (GO:0031115)2.56733709
98protein retention in ER lumen (GO:0006621)2.56296916
99regulation of early endosome to late endosome transport (GO:2000641)2.55786077
100nuclear pore organization (GO:0006999)2.55743561
101axonal fasciculation (GO:0007413)2.54802154
102plasma membrane repair (GO:0001778)2.53870466
103neuron recognition (GO:0008038)2.53103490
104axon extension (GO:0048675)2.52060596
105histone H3-K9 methylation (GO:0051567)2.51501772
106positive regulation of macrophage activation (GO:0043032)2.51437055
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.50731933
108neuron cell-cell adhesion (GO:0007158)2.50455022
109positive regulation of synapse maturation (GO:0090129)2.49939049
110proline transport (GO:0015824)2.49374110
111cell-cell junction maintenance (GO:0045217)2.49253630
112gene silencing by RNA (GO:0031047)2.48883022
113regulation of translational fidelity (GO:0006450)2.48801750
114synaptic vesicle docking involved in exocytosis (GO:0016081)2.48342429
115DNA unwinding involved in DNA replication (GO:0006268)2.48340154
116apical protein localization (GO:0045176)2.47941934
117microtubule-based movement (GO:0007018)2.46674933
118positive regulation of dendritic spine development (GO:0060999)2.46496186
119negative regulation of catenin import into nucleus (GO:0035414)2.45546122
120protein localization to endosome (GO:0036010)2.45516378
121regulation of vesicle fusion (GO:0031338)2.45281582
122meiotic nuclear division (GO:0007126)2.45066321
123sodium ion export (GO:0071436)2.44900863
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43730265
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42915056
126regulation of synapse structural plasticity (GO:0051823)2.42795782
127vesicle transport along microtubule (GO:0047496)2.42436103
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42420673
129camera-type eye morphogenesis (GO:0048593)2.41999248
130chaperone-mediated protein complex assembly (GO:0051131)2.41496146
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41262961
132convergent extension (GO:0060026)2.40279249
133stress granule assembly (GO:0034063)2.39236619
134exploration behavior (GO:0035640)2.39069568
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38212935
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37885507
137gamete generation (GO:0007276)2.36840854
138protein targeting to plasma membrane (GO:0072661)2.36781221
139positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.36343302
140long-term memory (GO:0007616)2.35876676
141glutamate secretion (GO:0014047)2.35752543
142neurotransmitter transport (GO:0006836)2.35530123
143dendritic spine morphogenesis (GO:0060997)2.35484203
144neurotransmitter-gated ion channel clustering (GO:0072578)2.35048888
145neural tube development (GO:0021915)2.34055214
146establishment of nucleus localization (GO:0040023)2.33787472
147cellular sodium ion homeostasis (GO:0006883)2.32293072
148negative regulation of inclusion body assembly (GO:0090084)2.32087023
149myelination in peripheral nervous system (GO:0022011)2.31615966
150peripheral nervous system axon ensheathment (GO:0032292)2.31615966
151neuron projection extension (GO:1990138)2.31235339
152positive regulation of dendrite development (GO:1900006)2.29319683
153vocalization behavior (GO:0071625)2.29085381
154histone H3-K9 modification (GO:0061647)2.29014242
155positive regulation of fibroblast migration (GO:0010763)2.28956011
156activation of protein kinase A activity (GO:0034199)2.28889447
157cell-substrate junction assembly (GO:0007044)2.28446460
158cellular protein complex localization (GO:0034629)2.28145208
159neuromuscular process controlling balance (GO:0050885)2.27068913
160regulation of clathrin-mediated endocytosis (GO:2000369)2.25004992
161calcium ion import (GO:0070509)2.23847896
162regulation of microtubule-based movement (GO:0060632)2.23825780
163cerebellar Purkinje cell layer development (GO:0021680)2.23271648
164gene silencing (GO:0016458)2.18678233
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.18586823
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.17417983
167genitalia morphogenesis (GO:0035112)2.13446313
168regulation of glutamate receptor signaling pathway (GO:1900449)2.12313967
169negative regulation of DNA repair (GO:0045738)2.11176311
170carnitine transmembrane transport (GO:1902603)2.07156156
171protein polyglutamylation (GO:0018095)2.06553209
172regulation of ARF protein signal transduction (GO:0032012)2.06521402
173protein kinase C signaling (GO:0070528)2.06469072
174DNA replication-dependent nucleosome assembly (GO:0006335)2.05737995
175cell wall macromolecule catabolic process (GO:0016998)15.1074755
176cell wall macromolecule metabolic process (GO:0044036)15.1074755
177fusion of sperm to egg plasma membrane (GO:0007342)10.8336602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.48924052
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.04291516
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.48544342
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.78246799
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.67232055
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66911108
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.64231309
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48011319
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.36650027
10LXR_22292898_ChIP-Seq_THP-1_Human2.35336098
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.28766542
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.26615268
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24825753
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20521157
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19739433
16* MYC_22102868_ChIP-Seq_BL_Human2.02353903
17ZNF274_21170338_ChIP-Seq_K562_Hela1.98924992
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98639382
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91522141
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91522141
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91104020
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89861639
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86970857
24* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82354934
25RACK7_27058665_Chip-Seq_MCF-7_Human1.81660552
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78115564
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77955452
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73122199
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.72672539
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72045471
31REST_21632747_ChIP-Seq_MESCs_Mouse1.71735827
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70776171
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.70506815
34EZH2_22144423_ChIP-Seq_EOC_Human1.67506864
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66810309
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.66741134
37* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65835410
38DROSHA_22980978_ChIP-Seq_HELA_Human1.65021972
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59854593
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.59706100
41TCF7_22412390_ChIP-Seq_EML_Mouse1.59524949
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.59219013
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59134256
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58054907
45ZNF263_19887448_ChIP-Seq_K562_Human1.56543416
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55982653
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55472350
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55316767
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54915966
50* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54909658
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53975427
52E2F7_22180533_ChIP-Seq_HELA_Human1.52685702
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51313153
54* CREB1_26743006_Chip-Seq_LNCaP_Human1.50956895
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47213685
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.46654480
57VDR_21846776_ChIP-Seq_THP-1_Human1.46122691
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45271767
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44450588
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43382376
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43381023
62CLOCK_20551151_ChIP-Seq_293T_Human1.41597293
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40831628
64KDM2B_26808549_Chip-Seq_REH_Human1.40309037
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40195801
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39419490
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39022059
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38952529
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38598530
70* SMC4_20622854_ChIP-Seq_HELA_Human1.38152996
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.36000144
72CTCF_27219007_Chip-Seq_Bcells_Human1.35993837
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.35822626
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35425644
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.35196127
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32623295
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32450865
78* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30921872
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.30841471
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29994291
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.29852186
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29315827
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28848744
84* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28764534
85P68_20966046_ChIP-Seq_HELA_Human1.28585234
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.27705492
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.27639809
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25019555
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24398430
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23182546
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22886361
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22714941
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21238479
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20315374
95AR_21572438_ChIP-Seq_LNCaP_Human1.20012317
96* SA1_27219007_Chip-Seq_ERYTHROID_Human1.19393265
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.19219135
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18256157
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15822605
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15532158
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.14676459
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.14510538
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14242962
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13747081
105KDM2B_26808549_Chip-Seq_K562_Human1.13313655
106* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13308301
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13105517
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12213083
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11927276
110LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11216918
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09545524
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09399679
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.09096012
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.06986586
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06317573
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06075896
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05787453
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05558410
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04751493
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04708951
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.04462529
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04041888
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.03574335
124TP53_22127205_ChIP-Seq_IMR90_Human1.03100184
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01649148
126FOXM1_23109430_ChIP-Seq_U2OS_Human1.01099883
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00466744
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98975777
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.98025222
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97840478
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97423191
132RNF2_27304074_Chip-Seq_NSC_Mouse0.97295716
133CBP_20019798_ChIP-Seq_JUKART_Human0.97029496
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97029496
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96644380
136* KDM2B_26808549_Chip-Seq_DND41_Human0.96316955
137AHR_22903824_ChIP-Seq_MCF-7_Human0.93732022
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93480774
139SOX9_26525672_Chip-Seq_HEART_Mouse0.92987187
140PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92985605
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.91805923
142NANOG_16518401_ChIP-PET_MESCs_Mouse0.90569273
143NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90360209
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.89790821
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89774362
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88654025
147* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88343445
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.88334576
149KDM2B_26808549_Chip-Seq_JURKAT_Human0.87764781
150* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87703354
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87086658
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85880124
153* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85763036
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.85151404
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.84945567
156ARNT_22903824_ChIP-Seq_MCF-7_Human0.84611486
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84597620
158* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84410671
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84237324
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83768566
161NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83443306
162NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83326476
163* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82664711
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.82381245
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82031110
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81619389
167SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81503067
168* STAT3_23295773_ChIP-Seq_U87_Human0.81369515
169CTCF_18555785_Chip-Seq_ESCs_Mouse0.80439710
170SMAD4_21799915_ChIP-Seq_A2780_Human0.80271546
171ESRRB_18555785_Chip-Seq_ESCs_Mouse0.79864477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.50208175
2MP0005623_abnormal_meninges_morphology4.38094742
3MP0002653_abnormal_ependyma_morphology3.99443711
4MP0004859_abnormal_synaptic_plasticity3.90293849
5MP0003705_abnormal_hypodermis_morpholog3.80758626
6MP0009046_muscle_twitch3.23864262
7MP0003698_abnormal_male_reproductive3.02921198
8MP0004233_abnormal_muscle_weight2.73853331
9MP0001929_abnormal_gametogenesis2.45855188
10MP0008877_abnormal_DNA_methylation2.40233611
11MP0010234_abnormal_vibrissa_follicle2.21816042
12MP0009780_abnormal_chondrocyte_physiolo2.21729908
13MP0003635_abnormal_synaptic_transmissio2.20052912
14MP0004858_abnormal_nervous_system2.14506166
15MP0005076_abnormal_cell_differentiation2.13796751
16MP0005409_darkened_coat_color2.11005118
17MP0000566_synostosis2.08982002
18MP0005275_abnormal_skin_tensile2.07942412
19MP0004270_analgesia2.01616780
20MP0000579_abnormal_nail_morphology1.94025464
21MP0010352_gastrointestinal_tract_polyps1.78964549
22MP0002249_abnormal_larynx_morphology1.78618221
23MP0008438_abnormal_cutaneous_collagen1.68774507
24MP0002161_abnormal_fertility/fecundity1.66721553
25MP0002063_abnormal_learning/memory/cond1.60451282
26MP0002210_abnormal_sex_determination1.57597706
27MP0001346_abnormal_lacrimal_gland1.53183161
28MP0002234_abnormal_pharynx_morphology1.52354907
29MP0001145_abnormal_male_reproductive1.51403460
30MP0004811_abnormal_neuron_physiology1.47083631
31MP0003283_abnormal_digestive_organ1.43365166
32MP0003890_abnormal_embryonic-extraembry1.41998627
33MP0003634_abnormal_glial_cell1.38275873
34MP0000569_abnormal_digit_pigmentation1.37500317
35MP0002822_catalepsy1.34842478
36MP0000653_abnormal_sex_gland1.31729315
37MP0009745_abnormal_behavioral_response1.31449383
38MP0008961_abnormal_basal_metabolism1.29842099
39MP0010307_abnormal_tumor_latency1.29516586
40MP0005187_abnormal_penis_morphology1.29064035
41MP0009672_abnormal_birth_weight1.28958950
42MP0003942_abnormal_urinary_system1.28956499
43MP0001502_abnormal_circadian_rhythm1.28610050
44MP0004185_abnormal_adipocyte_glucose1.27880810
45MP0002064_seizures1.27818642
46MP0000778_abnormal_nervous_system1.27172663
47MP0001299_abnormal_eye_distance/1.26773503
48MP0005257_abnormal_intraocular_pressure1.26610333
49MP0003329_amyloid_beta_deposits1.24221254
50MP0002272_abnormal_nervous_system1.23301792
51MP0000955_abnormal_spinal_cord1.22819306
52MP0002877_abnormal_melanocyte_morpholog1.22503826
53MP0010030_abnormal_orbit_morphology1.19388994
54MP0003119_abnormal_digestive_system1.17926669
55MP0001348_abnormal_lacrimal_gland1.17644129
56MP0000003_abnormal_adipose_tissue1.16602905
57MP0002282_abnormal_trachea_morphology1.16348710
58MP0003861_abnormal_nervous_system1.14575217
59MP0000537_abnormal_urethra_morphology1.14224511
60MP0002084_abnormal_developmental_patter1.13901137
61MP0002572_abnormal_emotion/affect_behav1.13442676
62MP0000751_myopathy1.10405554
63MP0002152_abnormal_brain_morphology1.10012536
64MP0002734_abnormal_mechanical_nocicepti1.09437399
65MP0003633_abnormal_nervous_system1.07971801
66MP0001968_abnormal_touch/_nociception1.07472636
67MP0004885_abnormal_endolymph1.04817086
68MP0002909_abnormal_adrenal_gland1.03139965
69MP0004130_abnormal_muscle_cell1.01937140
70MP0002184_abnormal_innervation1.01522820
71MP0003879_abnormal_hair_cell1.00813898
72MP0003122_maternal_imprinting1.00381981
73MP0003300_gastrointestinal_ulcer0.97946638
74MP0004197_abnormal_fetal_growth/weight/0.97081709
75MP0005423_abnormal_somatic_nervous0.96966503
76MP0001177_atelectasis0.95959471
77MP0001970_abnormal_pain_threshold0.94536831
78MP0002081_perinatal_lethality0.93577260
79MP0002116_abnormal_craniofacial_bone0.93095575
80MP0003115_abnormal_respiratory_system0.92746618
81MP0003631_nervous_system_phenotype0.91457678
82MP0000762_abnormal_tongue_morphology0.91132147
83MP0003787_abnormal_imprinting0.90249126
84MP0000678_abnormal_parathyroid_gland0.89673056
85MP0000462_abnormal_digestive_system0.87581010
86MP0001849_ear_inflammation0.87094607
87MP0002557_abnormal_social/conspecific_i0.83371447
88MP0002882_abnormal_neuron_morphology0.82943336
89MP0002269_muscular_atrophy0.82732917
90MP0003566_abnormal_cell_adhesion0.82488861
91MP0005666_abnormal_adipose_tissue0.82460448
92MP0003091_abnormal_cell_migration0.82225606
93MP0001188_hyperpigmentation0.81988005
94MP0003111_abnormal_nucleus_morphology0.81696234
95MP0002928_abnormal_bile_duct0.81194221
96MP0005375_adipose_tissue_phenotype0.81088377
97MP0001943_abnormal_respiration0.80981090
98MP0001440_abnormal_grooming_behavior0.80409094
99MP0002085_abnormal_embryonic_tissue0.80367922
100MP0003935_abnormal_craniofacial_develop0.79287901
101MP0002067_abnormal_sensory_capabilities0.79199256
102MP0005499_abnormal_olfactory_system0.79136247
103MP0005394_taste/olfaction_phenotype0.79136247
104MP0010769_abnormal_survival0.79090238
105MP0002102_abnormal_ear_morphology0.78273706
106MP0000747_muscle_weakness0.77848142
107MP0002733_abnormal_thermal_nociception0.77710771
108MP0003938_abnormal_ear_development0.76833406
109MP0005503_abnormal_tendon_morphology0.76763252
110MP0002082_postnatal_lethality0.76575522
111MP0010770_preweaning_lethality0.76575522
112MP0002735_abnormal_chemical_nociception0.75775474
113MP0008569_lethality_at_weaning0.75738552
114MP0002796_impaired_skin_barrier0.75700616
115MP0000467_abnormal_esophagus_morphology0.75658849
116MP0002697_abnormal_eye_size0.75586794
117MP0002114_abnormal_axial_skeleton0.75489739
118MP0004272_abnormal_basement_membrane0.75318048
119MP0003045_fibrosis0.74600928
120MP0010768_mortality/aging0.74381212
121MP0003690_abnormal_glial_cell0.74149581
122MP0003385_abnormal_body_wall0.73421269
123MP0000733_abnormal_muscle_development0.73306722
124MP0003123_paternal_imprinting0.72987282
125MP0000350_abnormal_cell_proliferation0.72131585
126MP0002089_abnormal_postnatal_growth/wei0.71776283
127MP0000920_abnormal_myelination0.71761927
128MP0001730_embryonic_growth_arrest0.71425900
129MP0009703_decreased_birth_body0.70887173
130MP0000534_abnormal_ureter_morphology0.70782971
131MP0003453_abnormal_keratinocyte_physiol0.70096007
132MP0009053_abnormal_anal_canal0.69148549
133MP0003632_abnormal_nervous_system0.68341809
134MP0002086_abnormal_extraembryonic_tissu0.67776634
135MP0000432_abnormal_head_morphology0.67679435
136MP0003880_abnormal_central_pattern0.67126309
137MP0002066_abnormal_motor_capabilities/c0.66725460
138MP0002233_abnormal_nose_morphology0.66504970
139MP0005380_embryogenesis_phenotype0.65179344
140MP0001672_abnormal_embryogenesis/_devel0.65179344
141MP0003984_embryonic_growth_retardation0.64378539
142MP0002088_abnormal_embryonic_growth/wei0.64258575
143MP0002108_abnormal_muscle_morphology0.64056953
144MP0001486_abnormal_startle_reflex0.63201523
145MP0008770_decreased_survivor_rate0.62958057
146MP0000428_abnormal_craniofacial_morphol0.62303881

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.90109689
2Absent/shortened dynein arms (HP:0200106)5.73253961
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.73253961
4Abnormal respiratory motile cilium physiology (HP:0012261)4.88360327
5Tongue fasciculations (HP:0001308)4.84916650
6Muscle fibrillation (HP:0010546)4.66450081
7Abnormal ciliary motility (HP:0012262)4.21261957
8Rhinitis (HP:0012384)4.15429220
9Obstructive sleep apnea (HP:0002870)4.02901282
10Impaired smooth pursuit (HP:0007772)3.97414702
11Abnormal respiratory epithelium morphology (HP:0012253)3.80083367
12Abnormal respiratory motile cilium morphology (HP:0005938)3.80083367
13Nasal polyposis (HP:0100582)3.63975465
14Chronic bronchitis (HP:0004469)3.62097887
15Slow saccadic eye movements (HP:0000514)3.45122056
16Abnormality of ocular smooth pursuit (HP:0000617)3.27109687
17Abnormality of the lower motor neuron (HP:0002366)3.20081637
18Renovascular hypertension (HP:0100817)3.19736523
19Hyperacusis (HP:0010780)3.16307270
20Abnormality of saccadic eye movements (HP:0000570)3.04540603
21Abnormality of the nasal mucosa (HP:0000433)2.89019040
22Turricephaly (HP:0000262)2.85946625
23Insomnia (HP:0100785)2.84776224
24Elfin facies (HP:0004428)2.80212624
25Supranuclear gaze palsy (HP:0000605)2.79630564
26Neurofibrillary tangles (HP:0002185)2.69303060
27Heterotopia (HP:0002282)2.64405644
28Renal duplication (HP:0000075)2.59063348
29Overriding aorta (HP:0002623)2.52303437
30Ulnar bowing (HP:0003031)2.52247394
31Broad face (HP:0000283)2.45840456
32Ankle clonus (HP:0011448)2.45232525
33Gait imbalance (HP:0002141)2.36141656
34Annular pancreas (HP:0001734)2.36129735
35Papillary thyroid carcinoma (HP:0002895)2.35144835
36Bronchomalacia (HP:0002780)2.32593071
37Bowel diverticulosis (HP:0005222)2.27086708
38Limb ataxia (HP:0002070)2.24367725
39Infertility (HP:0000789)2.24208126
40Flat cornea (HP:0007720)2.23463633
41Increased nuchal translucency (HP:0010880)2.23355003
42Polygenic inheritance (HP:0010982)2.19926867
43Premature rupture of membranes (HP:0001788)2.16508859
44Genetic anticipation (HP:0003743)2.16232909
45Bladder diverticulum (HP:0000015)2.14594803
46Termporal pattern (HP:0011008)2.14374571
47Insidious onset (HP:0003587)2.14374571
48Medial flaring of the eyebrow (HP:0010747)2.12519774
49Bronchiectasis (HP:0002110)2.11990714
50Amyotrophic lateral sclerosis (HP:0007354)2.11528496
51Focal motor seizures (HP:0011153)2.09926119
52Aplasia involving bones of the upper limbs (HP:0009823)2.09646418
53Aplasia of the phalanges of the hand (HP:0009802)2.09646418
54Aplasia involving bones of the extremities (HP:0009825)2.09646418
55Urethral obstruction (HP:0000796)2.08637548
56Dysmetric saccades (HP:0000641)2.08325054
57Hammertoe (HP:0001765)2.07418585
58Shallow orbits (HP:0000586)2.06766514
59Vertebral arch anomaly (HP:0008438)2.06712222
60Bronchitis (HP:0012387)2.06496842
61Urinary bladder sphincter dysfunction (HP:0002839)2.06365697
62Male infertility (HP:0003251)2.04180747
63Epileptic encephalopathy (HP:0200134)2.02316047
64Protrusio acetabuli (HP:0003179)2.01868765
65Long palpebral fissure (HP:0000637)2.00055259
66Congenital primary aphakia (HP:0007707)1.99652381
67Depression (HP:0000716)1.98923947
68Hyporeflexia of lower limbs (HP:0002600)1.96839448
69Absent frontal sinuses (HP:0002688)1.96306768
70Mitral regurgitation (HP:0001653)1.93439894
71Microglossia (HP:0000171)1.93020720
72Asymmetry of the thorax (HP:0001555)1.92991684
73Pointed chin (HP:0000307)1.91773279
74Buphthalmos (HP:0000557)1.91760817
75Abnormality of the corticospinal tract (HP:0002492)1.91400986
76Truncal ataxia (HP:0002078)1.91237793
77Disproportionate tall stature (HP:0001519)1.89344775
78Precocious puberty (HP:0000826)1.88787412
79Patellar dislocation (HP:0002999)1.86024222
80Sleep apnea (HP:0010535)1.83407376
81Fasciculations (HP:0002380)1.82269675
82Spastic gait (HP:0002064)1.81336844
83Urinary urgency (HP:0000012)1.80914357
84Abnormality of the astrocytes (HP:0100707)1.80288134
85Astrocytoma (HP:0009592)1.80288134
86Hypoventilation (HP:0002791)1.79948285
87Hyperparathyroidism (HP:0000843)1.79583272
88Abnormality of the diencephalon (HP:0010662)1.78555607
89Focal seizures (HP:0007359)1.78016357
90Deep palmar crease (HP:0006191)1.77703968
91Torticollis (HP:0000473)1.77206159
92Lower limb amyotrophy (HP:0007210)1.76637415
93Optic nerve hypoplasia (HP:0000609)1.76066621
94Cerebral inclusion bodies (HP:0100314)1.75375215
95Fragile skin (HP:0001030)1.75097864
96Impaired vibration sensation in the lower limbs (HP:0002166)1.74504154
97Germ cell neoplasia (HP:0100728)1.73761786
98Achilles tendon contracture (HP:0001771)1.73519303
99Cerebral aneurysm (HP:0004944)1.73248989
100Peripheral hypomyelination (HP:0007182)1.72164188
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.71002310
102Gait ataxia (HP:0002066)1.70332315
103Hypercortisolism (HP:0001578)1.69538427
104Megalocornea (HP:0000485)1.69325659
105Atrophic scars (HP:0001075)1.69127210
106Neuronal loss in central nervous system (HP:0002529)1.68433887
107Hypercalcemia (HP:0003072)1.68048226
108Visual hallucinations (HP:0002367)1.67919176
109Progressive cerebellar ataxia (HP:0002073)1.67850845
110Broad distal phalanx of finger (HP:0009836)1.67658979
111Bowel incontinence (HP:0002607)1.67207599
112Genital tract atresia (HP:0001827)1.67129830
113Thin ribs (HP:0000883)1.66250701
114Coronal craniosynostosis (HP:0004440)1.66198958
115Distal lower limb amyotrophy (HP:0008944)1.64422246
116Myokymia (HP:0002411)1.63905711
117Trigonocephaly (HP:0000243)1.63671014
118Recurrent otitis media (HP:0000403)1.63568166
119Biconcave vertebral bodies (HP:0004586)1.62946824
120Broad metatarsal (HP:0001783)1.62083864
121Disinhibition (HP:0000734)1.62038975
122Ankyloglossia (HP:0010296)1.61668813
123Neonatal short-limb short stature (HP:0008921)1.61369267
124Mitral valve prolapse (HP:0001634)1.61009477
125Dysmetria (HP:0001310)1.60978770
126Hyperextensible skin (HP:0000974)1.58790969
127Ankle contracture (HP:0006466)1.58196231
128Diplopia (HP:0000651)1.58087354
129Abnormality of binocular vision (HP:0011514)1.58087354
130Spinal cord compression (HP:0002176)1.57651190
131Spina bifida occulta (HP:0003298)1.57490515
132Overgrowth (HP:0001548)1.55212325
133High anterior hairline (HP:0009890)1.54696849
134Advanced eruption of teeth (HP:0006288)1.54292311
135Macroorchidism (HP:0000053)1.53682463
136Obsessive-compulsive behavior (HP:0000722)1.53485090
137Megalencephaly (HP:0001355)1.53427163
138Ventricular fibrillation (HP:0001663)1.53029220
139Distal upper limb amyotrophy (HP:0007149)1.52280193
140Upper limb amyotrophy (HP:0009129)1.52280193
141Vaginal atresia (HP:0000148)1.51949208
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.51584191
143Attention deficit hyperactivity disorder (HP:0007018)1.51488211
144Truncus arteriosus (HP:0001660)1.51366732
145Pseudobulbar signs (HP:0002200)1.50981428
146Akinesia (HP:0002304)1.50940591
147Genu recurvatum (HP:0002816)1.49839530
148Hypopigmentation of the fundus (HP:0007894)1.48689368
149Action tremor (HP:0002345)1.48137046
150Poor coordination (HP:0002370)1.46061510
151Nephrogenic diabetes insipidus (HP:0009806)1.45014965
152Sacral dimple (HP:0000960)1.43849094
153Arnold-Chiari malformation (HP:0002308)1.43223247
154Mutism (HP:0002300)1.43043215
155Intellectual disability, profound (HP:0002187)1.42475157
156Hallux valgus (HP:0001822)1.42401652
157Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41801676
158Morphological abnormality of the pyramidal tract (HP:0002062)1.40577652
159Abnormality of oral frenula (HP:0000190)1.39417629
160Hand muscle atrophy (HP:0009130)1.39263103
161Bundle branch block (HP:0011710)1.38684308
162Deviation of the hallux (HP:0010051)1.38118943
163Toxemia of pregnancy (HP:0100603)1.37413598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.77941518
2PDK35.77941518
3PDK23.42257964
4SMG12.91308489
5CDK122.70812788
6MAP3K92.69240744
7MARK12.41889691
8RIPK12.33841497
9PRPF4B2.24642024
10EEF2K2.06184141
11LMTK21.94984837
12TRIB31.93583893
13MAP3K41.86748487
14LATS21.84516437
15PKN21.76691923
16NTRK31.71784777
17TYRO31.66928539
18SCYL21.50290435
19ICK1.49067220
20PAK61.47795649
21PRKD31.45573745
22MINK11.44242274
23DDR21.40690683
24PDGFRA1.40111362
25KSR21.29142584
26LATS11.28434978
27FGFR41.26800152
28NEK11.26347816
29STK381.25838355
30NTRK11.25656958
31PTK2B1.25054547
32DAPK21.23332498
33MAP3K21.21811223
34MAP3K101.14186639
35ALK1.13289442
36RET1.11885455
37TTN1.10624057
38MAP2K41.10542629
39CAMKK11.08638651
40PDGFRB1.05008044
41EPHA41.02237705
42ARAF0.98304565
43NTRK20.97264781
44IRAK30.92579808
45MAP2K70.89440121
46PDK10.86810168
47CAMK1G0.82870426
48CASK0.82572509
49EPHA20.82433938
50MTOR0.81203571
51BMX0.78610237
52TAOK10.74647534
53CDK50.74019739
54STK110.73628418
55SIK20.72741327
56PTK60.72463863
57KSR10.70912320
58SGK30.70042338
59PRKCH0.69605599
60PNCK0.69484273
61BRAF0.69161197
62WNK40.68855009
63SGK2230.64874299
64SGK4940.64874299
65CAMK1D0.64042907
66BRSK10.63542309
67MAP3K130.61240324
68CHEK20.60984070
69FER0.59960313
70PAK20.58662333
71AKT30.57504410
72MARK20.57140992
73FGFR20.56851697
74MAPK120.56264165
75WNK10.55199813
76PKN10.54727506
77FGFR10.54339475
78CDK150.54168626
79PRKD20.53494622
80ROCK20.53009033
81NEK60.52790525
82CAMK2B0.52619416
83BRSK20.52573394
84PAK30.52453882
85CHEK10.52401947
86PLK20.51560396
87PTK20.50880984
88PHKG10.50459834
89PHKG20.50459834
90NEK20.50144670
91CSNK1D0.48680801
92CDK180.47818933
93MAPK100.47443043
94CDK60.46690134
95CDK140.46424448
96RAF10.46130307
97DMPK0.44237353
98HIPK20.44111458
99CAMK10.43199000
100CDC70.42414920
101PRKCG0.42202854
102CDK11A0.42129014
103STK390.42122603
104AKT20.41949715
105DAPK10.41832916
106EPHB20.41579502
107TSSK60.41167862
108DYRK1A0.40112532
109FGFR30.39812164
110SIK10.39752048
111CSNK1E0.39548960
112MET0.38693875
113PDPK10.38641846
114IRAK20.38604356
115MAPK110.38390233
116CDK70.37154188
117CDK10.36978514
118STK30.36620195
119CDC42BPA0.35612339
120PRKAA10.35353272
121MAP3K70.35328533
122EGFR0.34917301
123UHMK10.33123358
124MAPK80.33095801
125RPS6KA30.32852609
126PRKDC0.32176420
127CAMK2G0.31564030
128PRKCZ0.30952220
129MOS0.30944270
130CDK20.30772757
131RPS6KA20.30737271
132BRD40.29571393
133GSK3B0.29080084
134MAP3K60.28763138

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.61064772
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04519648
3Synaptic vesicle cycle_Homo sapiens_hsa047211.92972068
4Nitrogen metabolism_Homo sapiens_hsa009101.80719344
5Oocyte meiosis_Homo sapiens_hsa041141.71509161
6Long-term potentiation_Homo sapiens_hsa047201.71233224
7Estrogen signaling pathway_Homo sapiens_hsa049151.51757526
8Dorso-ventral axis formation_Homo sapiens_hsa043201.50637829
9Lysine degradation_Homo sapiens_hsa003101.46832285
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45742675
11Notch signaling pathway_Homo sapiens_hsa043301.45578959
12Glucagon signaling pathway_Homo sapiens_hsa049221.44399857
13Pentose phosphate pathway_Homo sapiens_hsa000301.41884809
14Circadian entrainment_Homo sapiens_hsa047131.40859017
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36751317
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36016359
17Amphetamine addiction_Homo sapiens_hsa050311.34737485
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33903691
19Vitamin B6 metabolism_Homo sapiens_hsa007501.32341021
20Olfactory transduction_Homo sapiens_hsa047401.31957725
21Systemic lupus erythematosus_Homo sapiens_hsa053221.31118876
22Dopaminergic synapse_Homo sapiens_hsa047281.30707435
23Gastric acid secretion_Homo sapiens_hsa049711.27629213
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25599461
25mTOR signaling pathway_Homo sapiens_hsa041501.25451094
26Insulin secretion_Homo sapiens_hsa049111.24232778
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23717258
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.23447461
29Type II diabetes mellitus_Homo sapiens_hsa049301.23336963
30Salivary secretion_Homo sapiens_hsa049701.22646007
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21002559
32Glutamatergic synapse_Homo sapiens_hsa047241.20454764
33Glioma_Homo sapiens_hsa052141.19528275
34Renin secretion_Homo sapiens_hsa049241.19245586
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17854092
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16410145
37Fatty acid biosynthesis_Homo sapiens_hsa000611.13056973
38Nicotine addiction_Homo sapiens_hsa050331.09970985
39Gap junction_Homo sapiens_hsa045401.07888079
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06376768
41Renin-angiotensin system_Homo sapiens_hsa046141.03923153
42MicroRNAs in cancer_Homo sapiens_hsa052061.03878838
43Adherens junction_Homo sapiens_hsa045201.02520483
44Oxytocin signaling pathway_Homo sapiens_hsa049211.01985971
45Bile secretion_Homo sapiens_hsa049761.00516418
46Cholinergic synapse_Homo sapiens_hsa047250.99684736
47GABAergic synapse_Homo sapiens_hsa047270.99311879
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.99007895
49Alcoholism_Homo sapiens_hsa050340.98480000
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98467838
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98168742
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97889364
53Biosynthesis of amino acids_Homo sapiens_hsa012300.97263404
54Endometrial cancer_Homo sapiens_hsa052130.97184808
55ErbB signaling pathway_Homo sapiens_hsa040120.96070278
56Axon guidance_Homo sapiens_hsa043600.95331771
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95184162
58Hippo signaling pathway_Homo sapiens_hsa043900.93964004
59Thyroid cancer_Homo sapiens_hsa052160.93213022
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91663475
61GnRH signaling pathway_Homo sapiens_hsa049120.90796379
62Basal cell carcinoma_Homo sapiens_hsa052170.90186645
63Inositol phosphate metabolism_Homo sapiens_hsa005620.89655412
64Morphine addiction_Homo sapiens_hsa050320.87917731
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87642024
66Tight junction_Homo sapiens_hsa045300.86495806
67Taste transduction_Homo sapiens_hsa047420.86481930
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86109468
69Melanogenesis_Homo sapiens_hsa049160.85695850
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85230588
71Long-term depression_Homo sapiens_hsa047300.84779676
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83948934
73Thyroid hormone synthesis_Homo sapiens_hsa049180.83539168
74Cocaine addiction_Homo sapiens_hsa050300.82211933
75Pancreatic cancer_Homo sapiens_hsa052120.81919585
76Focal adhesion_Homo sapiens_hsa045100.80088458
77AMPK signaling pathway_Homo sapiens_hsa041520.78751190
78Prostate cancer_Homo sapiens_hsa052150.78675835
79VEGF signaling pathway_Homo sapiens_hsa043700.78663703
80Calcium signaling pathway_Homo sapiens_hsa040200.77901873
81Vibrio cholerae infection_Homo sapiens_hsa051100.77669334
82Acute myeloid leukemia_Homo sapiens_hsa052210.76262939
83Insulin signaling pathway_Homo sapiens_hsa049100.75494468
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75422493
85Prolactin signaling pathway_Homo sapiens_hsa049170.75278189
86Proteoglycans in cancer_Homo sapiens_hsa052050.74560031
87cAMP signaling pathway_Homo sapiens_hsa040240.73974558
88Hedgehog signaling pathway_Homo sapiens_hsa043400.72730193
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.72560290
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72275599
91Non-small cell lung cancer_Homo sapiens_hsa052230.71731413
92Endocytosis_Homo sapiens_hsa041440.71067367
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70898385
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70254432
95ECM-receptor interaction_Homo sapiens_hsa045120.69870003
96Bladder cancer_Homo sapiens_hsa052190.68578808
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68481829
98Chronic myeloid leukemia_Homo sapiens_hsa052200.68019608
99Pyruvate metabolism_Homo sapiens_hsa006200.67741534
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66667353
101mRNA surveillance pathway_Homo sapiens_hsa030150.65865498
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.65772504
103Amoebiasis_Homo sapiens_hsa051460.65267865
104MAPK signaling pathway_Homo sapiens_hsa040100.65176756
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.64916171
106Colorectal cancer_Homo sapiens_hsa052100.64185126
107Rap1 signaling pathway_Homo sapiens_hsa040150.63689700
108Renal cell carcinoma_Homo sapiens_hsa052110.63617748
109Prion diseases_Homo sapiens_hsa050200.62873171
110Protein digestion and absorption_Homo sapiens_hsa049740.61735746
111Dilated cardiomyopathy_Homo sapiens_hsa054140.61539386
112Small cell lung cancer_Homo sapiens_hsa052220.61397537
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60872872
114Choline metabolism in cancer_Homo sapiens_hsa052310.60744635
115Wnt signaling pathway_Homo sapiens_hsa043100.60669269
116Insulin resistance_Homo sapiens_hsa049310.60513959
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60148320
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58259282
119Melanoma_Homo sapiens_hsa052180.57850588
120Ras signaling pathway_Homo sapiens_hsa040140.56020470

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