TNR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.61930077
2* locomotory exploration behavior (GO:0035641)5.53454451
3central nervous system myelination (GO:0022010)5.38588746
4axon ensheathment in central nervous system (GO:0032291)5.38588746
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23796612
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18560335
7vocalization behavior (GO:0071625)5.14250205
8* neuron cell-cell adhesion (GO:0007158)5.11867841
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.75730027
10synaptic vesicle maturation (GO:0016188)4.73082551
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72519775
12L-amino acid import (GO:0043092)4.72066464
13regulation of glutamate receptor signaling pathway (GO:1900449)4.60937855
14protein localization to synapse (GO:0035418)4.59856823
15regulation of synaptic vesicle exocytosis (GO:2000300)4.54679926
16neurotransmitter-gated ion channel clustering (GO:0072578)4.50584375
17presynaptic membrane assembly (GO:0097105)4.46573342
18amino acid import (GO:0043090)4.45663662
19synaptic vesicle exocytosis (GO:0016079)4.36826685
20postsynaptic membrane organization (GO:0001941)4.36374691
21potassium ion import (GO:0010107)4.35287431
22* exploration behavior (GO:0035640)4.25600311
23glutamate receptor signaling pathway (GO:0007215)4.21625804
24glutamate secretion (GO:0014047)4.19821846
25potassium ion homeostasis (GO:0055075)4.19751740
26transmission of nerve impulse (GO:0019226)4.18141346
27dendritic spine morphogenesis (GO:0060997)4.17229250
28synaptic transmission, glutamatergic (GO:0035249)4.13330834
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05847186
30regulation of synaptic vesicle transport (GO:1902803)4.02770483
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.96044016
32regulation of synapse maturation (GO:0090128)3.96023522
33neurotransmitter uptake (GO:0001504)3.92849774
34regulation of neuronal synaptic plasticity (GO:0048168)3.91288398
35presynaptic membrane organization (GO:0097090)3.88741878
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87872851
37positive regulation of membrane potential (GO:0045838)3.86515864
38neuron-neuron synaptic transmission (GO:0007270)3.77826738
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77524354
40neuronal action potential propagation (GO:0019227)3.77113056
41neuron recognition (GO:0008038)3.75017947
42long-term memory (GO:0007616)3.71421637
43dermatan sulfate metabolic process (GO:0030205)3.68933715
44neurotransmitter secretion (GO:0007269)3.68353231
45* long-term synaptic potentiation (GO:0060291)3.62362322
46startle response (GO:0001964)3.58949397
47dendrite morphogenesis (GO:0048813)3.57754139
48* positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.56574033
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55478935
50cellular potassium ion homeostasis (GO:0030007)3.48010966
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.47912204
52innervation (GO:0060384)3.46180638
53astrocyte differentiation (GO:0048708)3.44894274
54regulation of synapse structural plasticity (GO:0051823)3.41728206
55layer formation in cerebral cortex (GO:0021819)3.41167294
56membrane assembly (GO:0071709)3.40141118
57* regulation of synaptic transmission, glutamatergic (GO:0051966)3.39855681
58gamma-aminobutyric acid transport (GO:0015812)3.39594824
59photoreceptor cell differentiation (GO:0046530)3.39519431
60eye photoreceptor cell differentiation (GO:0001754)3.39519431
61membrane depolarization during action potential (GO:0086010)3.38409014
62regulation of postsynaptic membrane potential (GO:0060078)3.38403674
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36497353
64axonal fasciculation (GO:0007413)3.36019343
65neuronal ion channel clustering (GO:0045161)3.34326016
66cellular sodium ion homeostasis (GO:0006883)3.33867607
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30465571
68auditory behavior (GO:0031223)3.30246143
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28328827
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.27657308
71regulation of dendritic spine morphogenesis (GO:0061001)3.26379989
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26118258
73* regulation of synaptic plasticity (GO:0048167)3.25731335
74response to auditory stimulus (GO:0010996)3.25392960
75synapse assembly (GO:0007416)3.23867094
76cerebellar granule cell differentiation (GO:0021707)3.20874197
77neurotransmitter transport (GO:0006836)3.14318784
78oligodendrocyte differentiation (GO:0048709)3.13856599
79righting reflex (GO:0060013)3.12032407
80membrane hyperpolarization (GO:0060081)3.10223712
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09646465
82proline transport (GO:0015824)3.07452070
83regulation of neurotransmitter secretion (GO:0046928)3.07124698
84positive regulation of synapse maturation (GO:0090129)2.99436239
85synaptic vesicle endocytosis (GO:0048488)2.98688461
86dendritic spine organization (GO:0097061)2.98355537
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96365210
88regulation of neurotransmitter uptake (GO:0051580)2.95004226
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94578494
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.93575405
91cell communication by electrical coupling (GO:0010644)2.93083454
92regulation of respiratory system process (GO:0044065)2.92394210
93membrane depolarization (GO:0051899)2.91032240
94regulation of female receptivity (GO:0045924)2.91020411
95* synapse organization (GO:0050808)2.90933796
96regulation of voltage-gated calcium channel activity (GO:1901385)2.90178394
97* learning (GO:0007612)2.89612309
98C4-dicarboxylate transport (GO:0015740)2.88502212
99myelination (GO:0042552)2.88450929
100peripheral nervous system development (GO:0007422)2.88313726
101positive regulation of dendritic spine development (GO:0060999)2.88241561
102* neuromuscular process controlling balance (GO:0050885)2.88191958
103* positive regulation of synaptic transmission (GO:0050806)2.87340637
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86527370
105regulation of neurotransmitter transport (GO:0051588)2.86161162
106chondroitin sulfate catabolic process (GO:0030207)2.85520147
107prepulse inhibition (GO:0060134)2.83766963
108positive regulation of synapse assembly (GO:0051965)2.83465780
109cerebellar Purkinje cell differentiation (GO:0021702)2.82411185
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81077894
111mechanosensory behavior (GO:0007638)2.79965992
112regulation of neurotransmitter levels (GO:0001505)2.79592900
113dermatan sulfate biosynthetic process (GO:0030208)2.79484024
114* regulation of synaptic transmission (GO:0050804)2.78579987
115acidic amino acid transport (GO:0015800)2.78496725
116regulation of vesicle fusion (GO:0031338)2.78474647
117adult walking behavior (GO:0007628)2.77621792
118sodium ion export (GO:0071436)2.77482596
119detection of calcium ion (GO:0005513)2.76189120
120activation of protein kinase A activity (GO:0034199)2.75235782
121chemosensory behavior (GO:0007635)2.74893951
122L-glutamate transport (GO:0015813)2.74404376
123glycine transport (GO:0015816)2.73138734
124synaptic transmission (GO:0007268)2.71408700
125vesicle transport along microtubule (GO:0047496)2.68252103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20014293
2GBX2_23144817_ChIP-Seq_PC3_Human3.81350657
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02768958
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96403550
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92673343
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56520550
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56520550
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52379873
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49718611
10AR_21572438_ChIP-Seq_LNCaP_Human2.49035666
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47717744
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.47688623
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.43225837
14DROSHA_22980978_ChIP-Seq_HELA_Human2.40698328
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39258702
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38697169
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36486617
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.30451526
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17273560
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.16130604
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.12498571
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10626718
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07510085
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94759428
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88666911
26* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88360900
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83898798
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82234332
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79618374
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.75903966
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75270354
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66656327
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59513723
34* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59086269
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57687408
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56761602
37TAF15_26573619_Chip-Seq_HEK293_Human1.51882218
38P300_19829295_ChIP-Seq_ESCs_Human1.49539212
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.49054967
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46916881
41* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44760843
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42817697
43ZNF274_21170338_ChIP-Seq_K562_Hela1.42410749
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41583562
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.40746262
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.40694010
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40415442
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39622914
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39079121
50STAT3_23295773_ChIP-Seq_U87_Human1.38937910
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34798554
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33591471
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30172893
54AR_25329375_ChIP-Seq_VCAP_Human1.27162849
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.26950414
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26375640
57* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25342005
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22796853
59TCF4_23295773_ChIP-Seq_U87_Human1.22339825
60AR_19668381_ChIP-Seq_PC3_Human1.22220448
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20336134
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17517713
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16840753
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14746006
65FUS_26573619_Chip-Seq_HEK293_Human1.14550844
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14413585
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.14237320
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13938352
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13577187
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.13525812
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13346776
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11058521
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11058521
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.10921204
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10297696
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.09645317
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08576801
78TP53_16413492_ChIP-PET_HCT116_Human1.08569195
79RUNX2_22187159_ChIP-Seq_PCA_Human1.08432988
80ER_23166858_ChIP-Seq_MCF-7_Human1.07449627
81* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07316851
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07273342
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06450561
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.06388210
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06310594
86AHR_22903824_ChIP-Seq_MCF-7_Human1.06251006
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04406740
88IGF1R_20145208_ChIP-Seq_DFB_Human1.03426766
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.02956602
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01596799
91RNF2_27304074_Chip-Seq_NSC_Mouse1.01401285
92* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00832304
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99315851
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98854533
95* SMAD3_21741376_ChIP-Seq_HESCs_Human0.98708907
96* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98281552
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96593241
98* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96415578
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96176036
100* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95373076
101BCAT_22108803_ChIP-Seq_LS180_Human0.95023278
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93822059
103* KDM2B_26808549_Chip-Seq_REH_Human0.93300177
104BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92487665
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92245669
106SOX9_26525672_Chip-Seq_HEART_Mouse0.90529878
107JUN_21703547_ChIP-Seq_K562_Human0.90353390
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89985438
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88960038
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88621915
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87557868
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.87525710
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87502006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61565505
2MP0003880_abnormal_central_pattern4.88004049
3MP0003635_abnormal_synaptic_transmissio3.82681423
4MP0004270_analgesia3.38176120
5MP0009745_abnormal_behavioral_response3.18908749
6MP0005423_abnormal_somatic_nervous3.11744748
7MP0002064_seizures3.05498028
8MP0002063_abnormal_learning/memory/cond3.01828011
9MP0001968_abnormal_touch/_nociception2.75062294
10MP0001486_abnormal_startle_reflex2.75021480
11MP0002572_abnormal_emotion/affect_behav2.70979120
12MP0009046_muscle_twitch2.69485286
13* MP0002272_abnormal_nervous_system2.52931369
14MP0002734_abnormal_mechanical_nocicepti2.49482574
15MP0002736_abnormal_nociception_after2.19204412
16MP0001984_abnormal_olfaction2.08359830
17MP0009780_abnormal_chondrocyte_physiolo2.04683518
18MP0002822_catalepsy2.04603468
19MP0001440_abnormal_grooming_behavior2.01592870
20MP0002067_abnormal_sensory_capabilities2.01488176
21MP0001501_abnormal_sleep_pattern1.99266079
22MP0005646_abnormal_pituitary_gland1.99074037
23MP0004858_abnormal_nervous_system1.97470960
24MP0000778_abnormal_nervous_system1.95914685
25MP0002735_abnormal_chemical_nociception1.93731102
26MP0005645_abnormal_hypothalamus_physiol1.91043929
27MP0003172_abnormal_lysosome_physiology1.89184910
28MP0008569_lethality_at_weaning1.83586043
29MP0002733_abnormal_thermal_nociception1.83222110
30MP0004742_abnormal_vestibular_system1.80674235
31MP0001970_abnormal_pain_threshold1.80572821
32MP0002184_abnormal_innervation1.76086948
33MP0002557_abnormal_social/conspecific_i1.75967767
34MP0002909_abnormal_adrenal_gland1.65285043
35MP0004885_abnormal_endolymph1.65008012
36MP0001986_abnormal_taste_sensitivity1.63336188
37MP0003329_amyloid_beta_deposits1.58963803
38MP0000955_abnormal_spinal_cord1.57303438
39MP0000920_abnormal_myelination1.54867022
40MP0001529_abnormal_vocalization1.52020539
41MP0003690_abnormal_glial_cell1.51518292
42MP0005551_abnormal_eye_electrophysiolog1.50637144
43* MP0002882_abnormal_neuron_morphology1.47427202
44MP0005386_behavior/neurological_phenoty1.47340640
45MP0004924_abnormal_behavior1.47340640
46MP0004811_abnormal_neuron_physiology1.44437253
47MP0001502_abnormal_circadian_rhythm1.39298419
48MP0003787_abnormal_imprinting1.38315652
49MP0002066_abnormal_motor_capabilities/c1.38266069
50MP0004142_abnormal_muscle_tone1.37202334
51MP0003879_abnormal_hair_cell1.36779148
52MP0003183_abnormal_peptide_metabolism1.35017656
53MP0005171_absent_coat_pigmentation1.32290222
54MP0003633_abnormal_nervous_system1.31367254
55MP0006276_abnormal_autonomic_nervous1.26567587
56MP0004145_abnormal_muscle_electrophysio1.26329806
57MP0003634_abnormal_glial_cell1.26252715
58MP0010386_abnormal_urinary_bladder1.20270323
59MP0001905_abnormal_dopamine_level1.16008515
60MP0002229_neurodegeneration1.12761444
61MP0000631_abnormal_neuroendocrine_gland1.09984324
62MP0001485_abnormal_pinna_reflex1.09174878
63MP0002090_abnormal_vision1.06246255
64MP0005409_darkened_coat_color1.06171747
65* MP0002152_abnormal_brain_morphology1.05735919
66MP0001188_hyperpigmentation1.05434656
67MP0001963_abnormal_hearing_physiology1.04591438
68MP0000013_abnormal_adipose_tissue1.02922787
69* MP0003631_nervous_system_phenotype1.02701107
70MP0004782_abnormal_surfactant_physiolog1.00294543
71MP0003122_maternal_imprinting0.99016076
72MP0006072_abnormal_retinal_apoptosis0.96740370
73MP0001177_atelectasis0.96239477
74MP0003283_abnormal_digestive_organ0.94184179
75MP0002653_abnormal_ependyma_morphology0.93336701
76MP0002069_abnormal_eating/drinking_beha0.92459085
77MP0002752_abnormal_somatic_nervous0.92314966
78MP0002638_abnormal_pupillary_reflex0.91216467
79MP0001299_abnormal_eye_distance/0.88032129
80MP0005253_abnormal_eye_physiology0.85757025
81MP0003136_yellow_coat_color0.77895661
82MP0004130_abnormal_muscle_cell0.75796937
83MP0005379_endocrine/exocrine_gland_phen0.74636401
84MP0004147_increased_porphyrin_level0.74370516
85* MP0003632_abnormal_nervous_system0.73016468
86MP0005535_abnormal_body_temperature0.71411987
87MP0004043_abnormal_pH_regulation0.71118342
88MP0005167_abnormal_blood-brain_barrier0.70918220
89MP0000569_abnormal_digit_pigmentation0.70041656
90MP0005394_taste/olfaction_phenotype0.69843646
91MP0005499_abnormal_olfactory_system0.69843646
92MP0004085_abnormal_heartbeat0.69637639
93MP0008961_abnormal_basal_metabolism0.67372572
94MP0000579_abnormal_nail_morphology0.67308938
95MP0008874_decreased_physiological_sensi0.64182052
96MP0002876_abnormal_thyroid_physiology0.63899697
97MP0000604_amyloidosis0.63135949
98MP0000026_abnormal_inner_ear0.62399718
99MP0008872_abnormal_physiological_respon0.62098287
100MP0005623_abnormal_meninges_morphology0.61807072
101MP0003868_abnormal_feces_composition0.61757901
102MP0001943_abnormal_respiration0.60316415
103MP0010769_abnormal_survival0.60254356
104MP0010770_preweaning_lethality0.59651117
105MP0002082_postnatal_lethality0.59651117
106MP0004215_abnormal_myocardial_fiber0.59125574
107MP0003861_abnormal_nervous_system0.58534041
108MP0005195_abnormal_posterior_eye0.58102261
109MP0010768_mortality/aging0.56823279
110MP0003075_altered_response_to0.56245402
111MP0000462_abnormal_digestive_system0.54178504
112MP0003137_abnormal_impulse_conducting0.53171034
113MP0005670_abnormal_white_adipose0.50941751
114MP0003956_abnormal_body_size0.49896792
115MP0000639_abnormal_adrenal_gland0.48455608
116MP0002751_abnormal_autonomic_nervous0.41831627

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.77177061
2Myokymia (HP:0002411)5.47638987
3Focal seizures (HP:0007359)5.07328276
4Epileptic encephalopathy (HP:0200134)4.43234133
5Atonic seizures (HP:0010819)4.43048760
6Visual hallucinations (HP:0002367)4.33673854
7Progressive cerebellar ataxia (HP:0002073)4.29763313
8Febrile seizures (HP:0002373)4.24732049
9Action tremor (HP:0002345)3.72557309
10Absence seizures (HP:0002121)3.66374187
11Septo-optic dysplasia (HP:0100842)3.63163538
12Hyperventilation (HP:0002883)3.59356103
13Generalized tonic-clonic seizures (HP:0002069)3.47956698
14Dysdiadochokinesis (HP:0002075)3.47831022
15Broad-based gait (HP:0002136)3.46514375
16Supranuclear gaze palsy (HP:0000605)3.45256232
17Dialeptic seizures (HP:0011146)3.45160938
18Gaze-evoked nystagmus (HP:0000640)3.31575334
19Absent speech (HP:0001344)3.11553244
20Ankle clonus (HP:0011448)3.06926133
21Dysmetria (HP:0001310)3.05610809
22Neurofibrillary tangles (HP:0002185)3.02214870
23Obstructive sleep apnea (HP:0002870)2.98398811
24Postural instability (HP:0002172)2.97650137
25Truncal ataxia (HP:0002078)2.91862767
26Depression (HP:0000716)2.91840409
27Intention tremor (HP:0002080)2.90511951
28Limb dystonia (HP:0002451)2.90200180
29Blue irides (HP:0000635)2.84876103
30Impaired vibration sensation in the lower limbs (HP:0002166)2.84307280
31Hemiparesis (HP:0001269)2.83754957
32Scanning speech (HP:0002168)2.80652291
33Excessive salivation (HP:0003781)2.78871694
34Drooling (HP:0002307)2.78871694
35Morphological abnormality of the inner ear (HP:0011390)2.78505052
36Anxiety (HP:0000739)2.74701485
37Urinary bladder sphincter dysfunction (HP:0002839)2.73931163
38Abnormal eating behavior (HP:0100738)2.73000866
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.70535902
40Papilledema (HP:0001085)2.69522435
41Fetal akinesia sequence (HP:0001989)2.68996975
42Poor eye contact (HP:0000817)2.66054954
43Epileptiform EEG discharges (HP:0011182)2.65301492
44Mutism (HP:0002300)2.59662460
45Abnormality of the corticospinal tract (HP:0002492)2.59249740
46Optic nerve hypoplasia (HP:0000609)2.57263409
47EEG with generalized epileptiform discharges (HP:0011198)2.54754804
48Spastic gait (HP:0002064)2.54293257
49Impaired smooth pursuit (HP:0007772)2.50655379
50Abnormal social behavior (HP:0012433)2.49550521
51Impaired social interactions (HP:0000735)2.49550521
52Cerebral inclusion bodies (HP:0100314)2.43156140
53Peripheral hypomyelination (HP:0007182)2.42965252
54Split foot (HP:0001839)2.41714322
55Status epilepticus (HP:0002133)2.39593312
56Oligodactyly (hands) (HP:0001180)2.39069755
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38557089
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.38557089
59Genetic anticipation (HP:0003743)2.35928454
60Alacrima (HP:0000522)2.33926196
61Amblyopia (HP:0000646)2.32771541
62Hypsarrhythmia (HP:0002521)2.31930082
63Metabolic alkalosis (HP:0200114)2.31103686
64Abnormality of ocular smooth pursuit (HP:0000617)2.26000061
65Stereotypic behavior (HP:0000733)2.23176302
66Diplopia (HP:0000651)2.22206285
67Abnormality of binocular vision (HP:0011514)2.22206285
68Cerebral hypomyelination (HP:0006808)2.19789851
69Increased circulating renin level (HP:0000848)2.19662105
70Hemiplegia (HP:0002301)2.18969744
71Lower limb muscle weakness (HP:0007340)2.18275516
72Abnormality of cochlea (HP:0000375)2.17922304
73Bundle branch block (HP:0011710)2.17381191
74Megalencephaly (HP:0001355)2.17367587
75Sleep apnea (HP:0010535)2.16440615
76Abnormality of the sella turcica (HP:0002679)2.14914290
77Generalized myoclonic seizures (HP:0002123)2.13882216
78Torticollis (HP:0000473)2.13598881
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13015567
80Retinal dysplasia (HP:0007973)2.12671091
81Akinesia (HP:0002304)2.10857089
82Pheochromocytoma (HP:0002666)2.08439858
83Bradykinesia (HP:0002067)2.06373501
84Tetraplegia (HP:0002445)2.06002503
85Polyphagia (HP:0002591)2.04836438
86Widely spaced teeth (HP:0000687)2.03550583
87Hypokalemic alkalosis (HP:0001949)2.02996154
88Agitation (HP:0000713)2.02335393
89Urinary urgency (HP:0000012)1.95765866
90Gait imbalance (HP:0002141)1.94585390
91Progressive inability to walk (HP:0002505)1.93541492
92Spastic tetraparesis (HP:0001285)1.93257433
93Abnormality of the septum pellucidum (HP:0007375)1.93078787
94Focal dystonia (HP:0004373)1.93016640
95Impaired vibratory sensation (HP:0002495)1.91243954
96Type II lissencephaly (HP:0007260)1.90863500
97Hypomagnesemia (HP:0002917)1.89072485
98Absent septum pellucidum (HP:0001331)1.87977819
99Central scotoma (HP:0000603)1.87340792
100Abnormality of salivation (HP:0100755)1.85974544
101Rigidity (HP:0002063)1.85710434
102Gait ataxia (HP:0002066)1.84942520
103Morphological abnormality of the pyramidal tract (HP:0002062)1.83450820
104Clonus (HP:0002169)1.82483946
105Clumsiness (HP:0002312)1.81057468
106Abnormal drinking behavior (HP:0030082)1.79112834
107Polydipsia (HP:0001959)1.79112834
108Neuroendocrine neoplasm (HP:0100634)1.78891938
109Decreased lacrimation (HP:0000633)1.78553622
110Neoplasm of the peripheral nervous system (HP:0100007)1.77707854
111Anomalous pulmonary venous return (HP:0010772)1.77320677
112Abnormality of macular pigmentation (HP:0008002)1.77105251
113Thickened helices (HP:0000391)1.75926393
114Anosmia (HP:0000458)1.74637107
115Deep palmar crease (HP:0006191)1.74176888
116Abnormality of calcium-phosphate metabolism (HP:0100530)1.73721079
117Ventricular fibrillation (HP:0001663)1.73679912
118Aqueductal stenosis (HP:0002410)1.73456163
119Congenital stationary night blindness (HP:0007642)1.73455428
120Open mouth (HP:0000194)1.73001422
121Specific learning disability (HP:0001328)1.72332797
122Termporal pattern (HP:0011008)1.70638538
123Insidious onset (HP:0003587)1.70638538
124Hyperaldosteronism (HP:0000859)1.70490278
125Neuronal loss in central nervous system (HP:0002529)1.69446127
126Congenital sensorineural hearing impairment (HP:0008527)1.69377609
127Postural tremor (HP:0002174)1.69192621
128Spastic tetraplegia (HP:0002510)1.68220904
129Protruding tongue (HP:0010808)1.68103600
130Epiphyseal dysplasia (HP:0002656)1.66818272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.47146838
2CASK4.12609305
3EPHA43.95056644
4TNIK3.56371469
5MARK12.90452078
6FES2.73702070
7MAP3K42.69164504
8TYRO32.69034869
9MAP3K92.33831410
10MAP2K72.20372619
11MINK12.16709556
12NTRK22.16195870
13MAPK132.00561388
14PRPF4B1.95543497
15NTRK11.93283127
16PRKD31.80332680
17PAK61.75660848
18FRK1.74282797
19DAPK21.62892481
20MAP3K21.49991330
21RIPK41.49797885
22UHMK11.37488172
23CDK51.37366526
24KSR21.37064041
25CAMKK11.36784656
26MAP2K41.34920644
27IRAK21.22890367
28PHKG21.18950524
29PHKG11.18950524
30ERBB41.12482535
31PRKCG1.11562553
32NEK61.10539780
33PNCK1.10518816
34CAMK2G1.09354339
35KSR11.07877103
36MAP3K121.05661066
37WNK31.05185856
38STK381.03801990
39PLK21.01653078
40SGK4941.01332475
41SGK2231.01332475
42CAMK2A0.99363091
43DAPK10.96452663
44SIK20.95759109
45STK38L0.94220898
46OXSR10.92702165
47BMPR20.92364555
48PDGFRA0.91396010
49INSRR0.91319632
50FGFR20.90897619
51RET0.88186832
52PAK30.87267786
53GRK50.86825056
54PRKCH0.85632295
55PKN10.85288351
56SGK20.81411600
57CAMKK20.80935264
58CAMK2B0.80151242
59PDGFRB0.79008020
60CAMK40.74534553
61CAMK10.74171854
62MARK20.73823033
63MAPK120.73650007
64SGK10.73067409
65STK390.71357683
66IRAK10.70926334
67CAMK1G0.66895911
68PIK3CA0.66423922
69STK110.64077641
70PRKCE0.63936209
71CAMK2D0.63667785
72CDC42BPA0.62943856
73MAP3K130.61392645
74PINK10.60928793
75TAOK10.60172632
76DDR20.58378297
77DYRK1A0.58033868
78ERBB20.58009306
79AKT30.57794758
80CDK140.57576987
81MAPKAPK50.57518547
82RIPK10.56668900
83SGK30.55678543
84MAP3K10.55650942
85RPS6KA30.54873466
86CDK180.54803438
87CDK190.54668200
88FYN0.54439415
89CDK150.54073941
90GRK70.52143507
91ICK0.51166249
92TNK20.50834961
93PDK10.49861416
94WNK10.49708274
95CSNK1D0.49692579
96DMPK0.49350732
97LMTK20.47327942
98PDPK10.47190286
99ERBB30.46254007
100ROCK10.46251461
101BMX0.46117017
102ALK0.46109156
103PRKCZ0.45755926
104CSNK1G20.45664594
105CAMK1D0.45432839
106CDK11A0.45356002
107ROCK20.43717034
108MAPK100.42901489
109FGR0.42632762
110CSNK1A10.41525537
111CSNK1A1L0.41244408
112PRKCA0.40281794
113WNK40.38876102
114DYRK20.38570279
115PRKG10.37564209
116CDK30.37013186
117CSNK1G30.36735170
118PRKACA0.36685308
119PRKD20.36399233
120ARAF0.36306488
121FER0.36286574
122GSK3B0.32870944
123PRKCB0.32380113
124MAPK40.31773295

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63442024
2Glutamatergic synapse_Homo sapiens_hsa047242.82373683
3Synaptic vesicle cycle_Homo sapiens_hsa047212.79779276
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71238199
5GABAergic synapse_Homo sapiens_hsa047272.70255456
6Circadian entrainment_Homo sapiens_hsa047132.61643812
7Morphine addiction_Homo sapiens_hsa050322.49825728
8Long-term potentiation_Homo sapiens_hsa047202.41940740
9Olfactory transduction_Homo sapiens_hsa047402.38269673
10Amphetamine addiction_Homo sapiens_hsa050312.30108968
11Insulin secretion_Homo sapiens_hsa049112.22606646
12Cholinergic synapse_Homo sapiens_hsa047252.10559743
13Dopaminergic synapse_Homo sapiens_hsa047282.08270252
14Salivary secretion_Homo sapiens_hsa049702.07108008
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91128962
16Serotonergic synapse_Homo sapiens_hsa047261.81986249
17Gastric acid secretion_Homo sapiens_hsa049711.78222942
18Taste transduction_Homo sapiens_hsa047421.76844020
19Long-term depression_Homo sapiens_hsa047301.76266180
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73100338
21Renin secretion_Homo sapiens_hsa049241.66869577
22Cocaine addiction_Homo sapiens_hsa050301.58439185
23Oxytocin signaling pathway_Homo sapiens_hsa049211.57169469
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51329779
25Type II diabetes mellitus_Homo sapiens_hsa049301.50321959
26Calcium signaling pathway_Homo sapiens_hsa040201.49628498
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42862907
28GnRH signaling pathway_Homo sapiens_hsa049121.38296931
29Axon guidance_Homo sapiens_hsa043601.37823343
30Collecting duct acid secretion_Homo sapiens_hsa049661.33800062
31Gap junction_Homo sapiens_hsa045401.32502712
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31958644
33Bile secretion_Homo sapiens_hsa049761.31820388
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30706445
35cAMP signaling pathway_Homo sapiens_hsa040241.23507286
36Glioma_Homo sapiens_hsa052141.18348226
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15302205
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13146099
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09621767
40Estrogen signaling pathway_Homo sapiens_hsa049151.08534276
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05984023
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04275576
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.04077605
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02583319
45Vibrio cholerae infection_Homo sapiens_hsa051101.02285411
46Phototransduction_Homo sapiens_hsa047441.01638731
47Choline metabolism in cancer_Homo sapiens_hsa052311.00372373
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.00011385
49Pancreatic secretion_Homo sapiens_hsa049720.99596101
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99000394
51ErbB signaling pathway_Homo sapiens_hsa040120.98243539
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95835670
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87364012
54Thyroid hormone synthesis_Homo sapiens_hsa049180.87344771
55Histidine metabolism_Homo sapiens_hsa003400.86877110
56Melanogenesis_Homo sapiens_hsa049160.84453524
57Dorso-ventral axis formation_Homo sapiens_hsa043200.84313566
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79598296
59Prion diseases_Homo sapiens_hsa050200.79545085
60Butanoate metabolism_Homo sapiens_hsa006500.78326875
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77942647
62beta-Alanine metabolism_Homo sapiens_hsa004100.77908088
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74062761
64Cardiac muscle contraction_Homo sapiens_hsa042600.73716489
65Fatty acid biosynthesis_Homo sapiens_hsa000610.70507405
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.69306284
67Type I diabetes mellitus_Homo sapiens_hsa049400.68804553
68MAPK signaling pathway_Homo sapiens_hsa040100.68191363
69Vitamin B6 metabolism_Homo sapiens_hsa007500.67552890
70Dilated cardiomyopathy_Homo sapiens_hsa054140.65554552
71Circadian rhythm_Homo sapiens_hsa047100.63620171
72Ras signaling pathway_Homo sapiens_hsa040140.63154187
73Ether lipid metabolism_Homo sapiens_hsa005650.61559785
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60505952
75Nitrogen metabolism_Homo sapiens_hsa009100.60295430
76Sphingolipid metabolism_Homo sapiens_hsa006000.58509626
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56859487
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54511642
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54214256
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52067039
81Renal cell carcinoma_Homo sapiens_hsa052110.51483369
82ABC transporters_Homo sapiens_hsa020100.50446924
83Oocyte meiosis_Homo sapiens_hsa041140.49486014
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.49430483
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.49387529
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48466312
87Glucagon signaling pathway_Homo sapiens_hsa049220.48313453
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48175997
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46636023
90Rap1 signaling pathway_Homo sapiens_hsa040150.46019732
91Alcoholism_Homo sapiens_hsa050340.45381459
92Fatty acid metabolism_Homo sapiens_hsa012120.44890557
93Ovarian steroidogenesis_Homo sapiens_hsa049130.44713537
94Mineral absorption_Homo sapiens_hsa049780.44669552
95VEGF signaling pathway_Homo sapiens_hsa043700.42556947
96Endometrial cancer_Homo sapiens_hsa052130.42410348
97mTOR signaling pathway_Homo sapiens_hsa041500.41175766
98Endocytosis_Homo sapiens_hsa041440.41085334
99Inositol phosphate metabolism_Homo sapiens_hsa005620.40250085
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37444786
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36452503
102Wnt signaling pathway_Homo sapiens_hsa043100.36317308
103Chemokine signaling pathway_Homo sapiens_hsa040620.35581482
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35373598
105Glycerolipid metabolism_Homo sapiens_hsa005610.34439475
106PPAR signaling pathway_Homo sapiens_hsa033200.34057830
107Arginine and proline metabolism_Homo sapiens_hsa003300.33291363
108Non-small cell lung cancer_Homo sapiens_hsa052230.32736217
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32339767
110Arginine biosynthesis_Homo sapiens_hsa002200.32261247
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30654151
112AMPK signaling pathway_Homo sapiens_hsa041520.30545733
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30038415
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29912673
115Platelet activation_Homo sapiens_hsa046110.29883096
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.29338816
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28169087
118Insulin signaling pathway_Homo sapiens_hsa049100.27958984

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