TNRC18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)3.97483961
2mannose metabolic process (GO:0006013)3.95434590
3atrioventricular valve morphogenesis (GO:0003181)3.68811644
4planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67836915
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.67720880
6insulin-like growth factor receptor signaling pathway (GO:0048009)3.63479430
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.57150503
8endothelial cell chemotaxis (GO:0035767)3.56808408
9protein heterotrimerization (GO:0070208)3.54961265
10cell-cell junction maintenance (GO:0045217)3.35932281
11layer formation in cerebral cortex (GO:0021819)3.32782687
12plasma membrane repair (GO:0001778)3.31973346
13activation of Rac GTPase activity (GO:0032863)3.30221948
14positive regulation of histone deacetylation (GO:0031065)3.22752929
15desmosome organization (GO:0002934)3.17401133
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14198977
17positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.12916902
18negative regulation of catenin import into nucleus (GO:0035414)3.11426516
19positive regulation of fatty acid beta-oxidation (GO:0032000)3.08754061
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.08212639
21axon extension involved in axon guidance (GO:0048846)3.08212639
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07507317
23hippo signaling (GO:0035329)3.07319220
24negative regulation of cell size (GO:0045792)3.03296959
25negative regulation of fatty acid transport (GO:2000192)3.00203042
26cytoplasmic mRNA processing body assembly (GO:0033962)2.99156024
27adherens junction assembly (GO:0034333)2.97188699
28stress fiber assembly (GO:0043149)2.94762765
29negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93977701
30semaphorin-plexin signaling pathway (GO:0071526)2.93893258
31regulation of glucose import in response to insulin stimulus (GO:2001273)2.89436626
32apoptotic cell clearance (GO:0043277)2.87965758
33negative regulation of myotube differentiation (GO:0010832)2.87625928
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86239022
35cell-substrate junction assembly (GO:0007044)2.85497342
36regulation of NFAT protein import into nucleus (GO:0051532)2.82123798
37glial cell proliferation (GO:0014009)2.79733284
38regulation of extracellular matrix disassembly (GO:0010715)2.77742365
39positive regulation of receptor recycling (GO:0001921)2.76466095
40establishment of nucleus localization (GO:0040023)2.76197040
41endodermal cell differentiation (GO:0035987)2.75587845
42positive regulation of protein deacetylation (GO:0090312)2.75489455
43regulation of endothelial cell chemotaxis (GO:2001026)2.75413981
44regulation of hippo signaling (GO:0035330)2.73640539
45glucocorticoid receptor signaling pathway (GO:0042921)2.72723086
46gastrulation with mouth forming second (GO:0001702)2.66932279
47hemidesmosome assembly (GO:0031581)2.62433062
48cell migration in hindbrain (GO:0021535)2.61299154
49polarized epithelial cell differentiation (GO:0030859)2.60268996
50embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60176994
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59841846
52positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58337599
53epithelial cell-cell adhesion (GO:0090136)2.58238090
54bone trabecula formation (GO:0060346)2.57051334
55branching involved in mammary gland duct morphogenesis (GO:0060444)2.56510119
56positive regulation of Cdc42 GTPase activity (GO:0043089)2.55504598
57response to muramyl dipeptide (GO:0032495)2.55446881
58anatomical structure regression (GO:0060033)2.55000347
59collagen fibril organization (GO:0030199)2.54141563
60embryonic eye morphogenesis (GO:0048048)2.53576616
61positive regulation of glycogen biosynthetic process (GO:0045725)2.51727565
62skin morphogenesis (GO:0043589)2.51723647
63peptidyl-tyrosine autophosphorylation (GO:0038083)2.51567170
64activation of JUN kinase activity (GO:0007257)2.51292782
65positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49223482
66intracellular estrogen receptor signaling pathway (GO:0030520)2.49199073
67cell-substrate adherens junction assembly (GO:0007045)2.49107444
68focal adhesion assembly (GO:0048041)2.49107444
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48988597
70cardiac myofibril assembly (GO:0055003)2.48713872
71osteoblast development (GO:0002076)2.48500658
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.48186018
73peptidyl-lysine dimethylation (GO:0018027)2.47995449
74protein localization to endosome (GO:0036010)2.47949575
75heart morphogenesis (GO:0003007)2.43593899
76apoptotic process involved in development (GO:1902742)2.42116860
77epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41924964
78embryonic process involved in female pregnancy (GO:0060136)2.41821753
79regulation of ARF GTPase activity (GO:0032312)2.41778709
80response to laminar fluid shear stress (GO:0034616)2.41765879
81positive regulation of CREB transcription factor activity (GO:0032793)2.41345831
82regulation of ARF protein signal transduction (GO:0032012)2.41097702
83collecting duct development (GO:0072044)2.41061535
84regulation of histone deacetylation (GO:0031063)2.40058338
85negative regulation of viral release from host cell (GO:1902187)2.39213364
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38886847
87embryonic camera-type eye morphogenesis (GO:0048596)2.38757839
88maternal placenta development (GO:0001893)2.38508084
89cell adhesion mediated by integrin (GO:0033627)2.38464125
90regulation of establishment of planar polarity (GO:0090175)2.37988599
91regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.37155835
92negative regulation of glial cell proliferation (GO:0060253)2.36335674
93regulation of integrin activation (GO:0033623)2.35980705
94regulation of cholesterol homeostasis (GO:2000188)2.35211069
95basement membrane organization (GO:0071711)2.34698704
96lateral sprouting from an epithelium (GO:0060601)2.34286400
97ear development (GO:0043583)2.34026235
98venous blood vessel morphogenesis (GO:0048845)2.33855713
99response to fluid shear stress (GO:0034405)2.32033231
100neural tube development (GO:0021915)2.31051462
101regulation of histone H3-K27 methylation (GO:0061085)2.31037591
102sodium ion export (GO:0071436)2.30439250
103embryonic foregut morphogenesis (GO:0048617)2.29176591
104negative regulation of granulocyte differentiation (GO:0030853)2.28690127
105germ cell migration (GO:0008354)2.28068478
106regulation of fatty acid beta-oxidation (GO:0031998)2.27844743
107regulation of p38MAPK cascade (GO:1900744)2.27830256
108cell migration involved in sprouting angiogenesis (GO:0002042)2.27622814
109Rho protein signal transduction (GO:0007266)2.26813390
110positive regulation of fibroblast migration (GO:0010763)2.25835318
111NLS-bearing protein import into nucleus (GO:0006607)2.25519789
112positive regulation of Rac GTPase activity (GO:0032855)2.24846852
113thymic T cell selection (GO:0045061)2.23261067
114corticosteroid receptor signaling pathway (GO:0031958)2.22787236
115camera-type eye morphogenesis (GO:0048593)2.21957611
116eye morphogenesis (GO:0048592)2.21941967
117axon extension (GO:0048675)2.21840387
118establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.21112498
119lung epithelium development (GO:0060428)2.19619850
120cortical actin cytoskeleton organization (GO:0030866)2.19600512
121barbed-end actin filament capping (GO:0051016)2.18999781
122growth hormone receptor signaling pathway (GO:0060396)2.18430868
123signal complex assembly (GO:0007172)2.18320593
124regulation of extracellular matrix organization (GO:1903053)2.18241457
125adherens junction organization (GO:0034332)2.18186260
126heart valve morphogenesis (GO:0003179)2.17537022
127positive regulation of epithelial to mesenchymal transition (GO:0010718)2.17316903
128cell volume homeostasis (GO:0006884)2.15992369
129actin filament bundle assembly (GO:0051017)2.15931656
130actin filament bundle organization (GO:0061572)2.15931656
131receptor catabolic process (GO:0032801)2.13706214
132cardiac muscle cell proliferation (GO:0060038)2.13541182
133locomotory exploration behavior (GO:0035641)2.13428125
134negative regulation of chondrocyte differentiation (GO:0032331)2.13298702
135cellular response to epidermal growth factor stimulus (GO:0071364)2.12317563
136chondrocyte proliferation (GO:0035988)2.12146808
137cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.11672137
138establishment of apical/basal cell polarity (GO:0035089)2.11593997
139regulation of tight junction assembly (GO:2000810)2.11583298
140non-canonical Wnt signaling pathway (GO:0035567)2.10482719
141cell migration involved in heart development (GO:0060973)2.09456144
142vascular endothelial growth factor signaling pathway (GO:0038084)2.09110934
143blood vessel endothelial cell migration (GO:0043534)2.08655282
144apoptotic process involved in morphogenesis (GO:0060561)2.07905161
145protein targeting to plasma membrane (GO:0072661)2.07285156
146negative regulation of cardiac muscle tissue growth (GO:0055022)2.07216332
147negative regulation of heart growth (GO:0061117)2.07216332
148cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.07031426
149renal system development (GO:0072001)2.07020339
150dendrite morphogenesis (GO:0048813)2.06794060
151negative regulation of smooth muscle cell migration (GO:0014912)2.06575643
152positive regulation of axon extension (GO:0045773)2.06531475
153stress granule assembly (GO:0034063)2.06051401
154positive regulation of glycogen metabolic process (GO:0070875)2.05420919
155pre-miRNA processing (GO:0031054)2.04972584
156cell junction maintenance (GO:0034331)2.04531605
157collagen metabolic process (GO:0032963)2.04414943
158multicellular organismal macromolecule metabolic process (GO:0044259)2.03732277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.21002090
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09144391
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88305556
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73407958
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66611211
6* KDM2B_26808549_Chip-Seq_DND41_Human2.39375677
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.35835454
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.24095526
9* KDM2B_26808549_Chip-Seq_K562_Human2.21770984
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18785622
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16942836
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.09195386
13* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06414307
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06308288
15MYC_22102868_ChIP-Seq_BL_Human2.02755847
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.02675553
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.00694129
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97495990
19LXR_22292898_ChIP-Seq_THP-1_Human1.94806957
20* KDM2B_26808549_Chip-Seq_JURKAT_Human1.93083711
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92604286
22* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.90102077
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.87427326
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84761742
25DROSHA_22980978_ChIP-Seq_HELA_Human1.80103736
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.73945250
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67688718
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65222045
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63760361
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.61791980
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60168491
32P68_20966046_ChIP-Seq_HELA_Human1.59180689
33RACK7_27058665_Chip-Seq_MCF-7_Human1.58820062
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57114071
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57078855
36* VDR_21846776_ChIP-Seq_THP-1_Human1.56970353
37* SMC4_20622854_ChIP-Seq_HELA_Human1.53167170
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51173513
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50046675
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47719437
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46841678
42CLOCK_20551151_ChIP-Seq_293T_Human1.44670038
43* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43841562
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.42195003
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41859575
46ZNF263_19887448_ChIP-Seq_K562_Human1.40975324
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38109745
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37558001
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37558001
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37346547
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36379815
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35575911
53* ISL1_27105846_Chip-Seq_CPCs_Mouse1.34062724
54* CREB1_26743006_Chip-Seq_LNCaP_Human1.33609861
55* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32389407
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31143746
57* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28083343
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28063485
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28056881
60CTCF_27219007_Chip-Seq_Bcells_Human1.26931129
61* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26763753
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24720316
63* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23979920
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.22607069
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.21596290
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.21596290
67* RNF2_27304074_Chip-Seq_ESCs_Mouse1.20681282
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20277759
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19706183
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19609051
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18140561
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17874006
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15239118
74* TP53_22127205_ChIP-Seq_IMR90_Human1.14684511
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.14569473
76TP63_22573176_ChIP-Seq_HFKS_Human1.13880125
77SCL_19346495_ChIP-Seq_HPC-7_Human1.12242781
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11909908
79MAF_26560356_Chip-Seq_TH2_Human1.10422735
80* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09272237
81* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08421054
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07719205
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07650105
84* RARB_27405468_Chip-Seq_BRAIN_Mouse1.07540519
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07381805
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.07249058
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06499964
88* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06384636
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05654591
90SPI1_23127762_ChIP-Seq_K562_Human1.05271044
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05180540
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04137892
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04136667
94* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03884755
95BCOR_27268052_Chip-Seq_Bcells_Human1.03683686
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03595698
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03478547
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03376738
99* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03146248
100* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02596709
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02531925
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02445399
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.02325147
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.01733136
105ATF3_27146783_Chip-Seq_COLON_Human1.00956534
106UTX_26944678_Chip-Seq_JUKART_Human1.00700524
107AHR_22903824_ChIP-Seq_MCF-7_Human1.00546574
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.00039339
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.99937319
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99815600
111* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99812987
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.98482327
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98451437
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98037649
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97341746
116* KLF5_25053715_ChIP-Seq_YYC3_Human0.96878823
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96825213
118* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96809736
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.96549544
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.96207979
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95956990
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95717078
123JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95607966
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.95541449
125* VDR_24763502_ChIP-Seq_THP-1_Human0.95301733
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95037427
127MAF_26560356_Chip-Seq_TH1_Human0.94953642
128GATA1_19941826_ChIP-Seq_K562_Human0.94892090
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94376561
130* UBF1/2_26484160_Chip-Seq_HMECs_Human0.94100759
131* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94001587
132EZH2_27304074_Chip-Seq_ESCs_Mouse0.93853347
133* NCOR1_26117541_ChIP-Seq_K562_Human0.93575081
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93485866
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92438439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.70376384
2MP0008438_abnormal_cutaneous_collagen3.61551512
3MP0005076_abnormal_cell_differentiation3.09766587
4MP0005409_darkened_coat_color2.94446636
5MP0000569_abnormal_digit_pigmentation2.91459667
6MP0005623_abnormal_meninges_morphology2.67083782
7MP0009278_abnormal_bone_marrow2.60347063
8MP0000566_synostosis2.40954221
9MP0005275_abnormal_skin_tensile2.28037747
10MP0001958_emphysema2.21977039
11MP0005058_abnormal_lysosome_morphology2.20765581
12MP0003172_abnormal_lysosome_physiology2.13224397
13MP0003300_gastrointestinal_ulcer2.11706354
14MP0003279_aneurysm2.09634511
15MP0010352_gastrointestinal_tract_polyps2.07328488
16MP0003566_abnormal_cell_adhesion2.07030374
17MP0003283_abnormal_digestive_organ2.05039358
18MP0004858_abnormal_nervous_system2.03509702
19MP0000537_abnormal_urethra_morphology2.02446098
20MP0000733_abnormal_muscle_development2.01579978
21MP0001849_ear_inflammation1.93213564
22MP0003453_abnormal_keratinocyte_physiol1.89359713
23MP0003091_abnormal_cell_migration1.86685434
24MP0009053_abnormal_anal_canal1.84301808
25MP0004381_abnormal_hair_follicle1.84090894
26MP0010030_abnormal_orbit_morphology1.82098144
27MP0004272_abnormal_basement_membrane1.78934392
28MP0003385_abnormal_body_wall1.76362650
29MP0009780_abnormal_chondrocyte_physiolo1.74218721
30MP0010234_abnormal_vibrissa_follicle1.72971222
31MP0003303_peritoneal_inflammation1.72879607
32MP0003045_fibrosis1.69735881
33MP0003115_abnormal_respiratory_system1.69648840
34MP0008961_abnormal_basal_metabolism1.67169697
35MP0000428_abnormal_craniofacial_morphol1.63431739
36MP0000678_abnormal_parathyroid_gland1.61474259
37MP0006054_spinal_hemorrhage1.60295309
38MP0001348_abnormal_lacrimal_gland1.59760628
39MP0000751_myopathy1.57343628
40MP0002234_abnormal_pharynx_morphology1.53949982
41MP0004264_abnormal_extraembryonic_tissu1.52635083
42MP0008260_abnormal_autophagy1.50429880
43MP0005503_abnormal_tendon_morphology1.49857513
44MP0002796_impaired_skin_barrier1.47234021
45MP0005670_abnormal_white_adipose1.45976114
46MP0000534_abnormal_ureter_morphology1.45202970
47MP0004859_abnormal_synaptic_plasticity1.44820103
48MP0005248_abnormal_Harderian_gland1.43528460
49MP0003436_decreased_susceptibility_to1.42847109
50MP0002896_abnormal_bone_mineralization1.38271273
51MP0004947_skin_inflammation1.36340607
52MP0005451_abnormal_body_composition1.34033555
53MP0005257_abnormal_intraocular_pressure1.33821268
54MP0005023_abnormal_wound_healing1.28579543
55MP0003935_abnormal_craniofacial_develop1.23661650
56MP0009384_cardiac_valve_regurgitation1.22318687
57MP0003191_abnormal_cellular_cholesterol1.22235957
58MP0002098_abnormal_vibrissa_morphology1.21976428
59MP0005508_abnormal_skeleton_morphology1.20220908
60MP0010630_abnormal_cardiac_muscle1.18968369
61MP0002089_abnormal_postnatal_growth/wei1.18132011
62MP0004233_abnormal_muscle_weight1.16857974
63MP0000767_abnormal_smooth_muscle1.14591280
64MP0003942_abnormal_urinary_system1.14582928
65MP0003329_amyloid_beta_deposits1.12881540
66MP0002060_abnormal_skin_morphology1.12250599
67MP0002933_joint_inflammation1.11363367
68MP0004087_abnormal_muscle_fiber1.09529358
69MP0002925_abnormal_cardiovascular_devel1.08803514
70MP0002653_abnormal_ependyma_morphology1.08217484
71MP0002932_abnormal_joint_morphology1.07743864
72MP0002396_abnormal_hematopoietic_system1.05419310
73MP0002282_abnormal_trachea_morphology1.05393722
74MP0004510_myositis1.05361565
75MP0000003_abnormal_adipose_tissue1.04997718
76MP0002116_abnormal_craniofacial_bone1.03878667
77MP0005501_abnormal_skin_physiology1.03324078
78MP0003755_abnormal_palate_morphology1.02725802
79MP0003119_abnormal_digestive_system1.00789954
80MP0003183_abnormal_peptide_metabolism1.00260927
81MP0004197_abnormal_fetal_growth/weight/0.98273964
82MP0002249_abnormal_larynx_morphology0.97131794
83MP0009840_abnormal_foam_cell0.97088978
84MP0005187_abnormal_penis_morphology0.96260961
85MP0006138_congestive_heart_failure0.95849109
86MP0005375_adipose_tissue_phenotype0.94872971
87MP0000858_altered_metastatic_potential0.94665041
88MP0009931_abnormal_skin_appearance0.94051245
89MP0002168_other_aberrant_phenotype0.92902702
90MP0002877_abnormal_melanocyte_morpholog0.92269181
91MP0000049_abnormal_middle_ear0.92074018
92MP0005390_skeleton_phenotype0.91558644
93MP0000516_abnormal_urinary_system0.91370110
94MP0005367_renal/urinary_system_phenotyp0.91370110
95MP0001299_abnormal_eye_distance/0.90699323
96MP0004084_abnormal_cardiac_muscle0.90418746
97MP0002108_abnormal_muscle_morphology0.89950928
98MP0010368_abnormal_lymphatic_system0.89759860
99MP0002697_abnormal_eye_size0.88273335
100MP0001873_stomach_inflammation0.86793385
101MP0002092_abnormal_eye_morphology0.86532800
102MP0004782_abnormal_surfactant_physiolog0.85615950
103MP0004185_abnormal_adipocyte_glucose0.85430302
104MP0002128_abnormal_blood_circulation0.85351241
105MP0000266_abnormal_heart_morphology0.84381378
106MP0001216_abnormal_epidermal_layer0.84000576
107MP0000579_abnormal_nail_morphology0.82896367
108MP0000432_abnormal_head_morphology0.82814528
109MP0001915_intracranial_hemorrhage0.82609253
110MP0002254_reproductive_system_inflammat0.81623019
111MP0000681_abnormal_thyroid_gland0.81035741
112MP0004808_abnormal_hematopoietic_stem0.78975533
113MP0002084_abnormal_developmental_patter0.77595797
114MP0009250_abnormal_appendicular_skeleto0.77591696
115MP0000462_abnormal_digestive_system0.77239768
116MP0005666_abnormal_adipose_tissue0.76979594
117MP0004130_abnormal_muscle_cell0.76354059
118MP0010678_abnormal_skin_adnexa0.75361543
119MP0001614_abnormal_blood_vessel0.75211348
120MP0003567_abnormal_fetal_cardiomyocyte0.75107390
121MP0000467_abnormal_esophagus_morphology0.74651282
122MP0000013_abnormal_adipose_tissue0.74225637
123MP0003828_pulmonary_edema0.74163620
124MP0001533_abnormal_skeleton_physiology0.73857595
125MP0000778_abnormal_nervous_system0.73407381
126MP0005621_abnormal_cell_physiology0.73338762
127MP0003861_abnormal_nervous_system0.73127784
128MP0001784_abnormal_fluid_regulation0.72705706
129MP0008770_decreased_survivor_rate0.71745842
130MP0000470_abnormal_stomach_morphology0.71200696
131MP0002115_abnormal_skeleton_extremities0.70973415
132MP0000762_abnormal_tongue_morphology0.70623022
133MP0002909_abnormal_adrenal_gland0.70514824
134MP0009703_decreased_birth_body0.70281789
135MP0000759_abnormal_skeletal_muscle0.70142417
136MP0002998_abnormal_bone_remodeling0.69353166
137MP0005083_abnormal_biliary_tract0.69082206
138MP0001664_abnormal_digestion0.68028178
139MP0002113_abnormal_skeleton_development0.67204823
140MP0010771_integument_phenotype0.66995569
141MP0000377_abnormal_hair_follicle0.66070604
142MP0003866_abnormal_defecation0.65937551
143MP0002970_abnormal_white_adipose0.65229620
144MP0000249_abnormal_blood_vessel0.63383114
145MP0003879_abnormal_hair_cell0.63106754

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.49192648
2Protrusio acetabuli (HP:0003179)4.14118656
3Broad face (HP:0000283)4.02446484
4Cerebral aneurysm (HP:0004944)3.86648062
5Premature rupture of membranes (HP:0001788)3.52320379
6Hyperacusis (HP:0010780)3.49139697
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.43861920
8Short 4th metacarpal (HP:0010044)3.43861920
9Ankle contracture (HP:0006466)3.32193071
10Broad metatarsal (HP:0001783)3.26644651
11Bladder diverticulum (HP:0000015)3.19122454
12Atrophic scars (HP:0001075)2.99536310
13Abnormality of the 4th metacarpal (HP:0010012)2.85485592
14Mitral valve prolapse (HP:0001634)2.77820476
15Elfin facies (HP:0004428)2.63964165
16Renal duplication (HP:0000075)2.63545437
17Renovascular hypertension (HP:0100817)2.63290523
18Abnormality of the fingertips (HP:0001211)2.60629294
19Aortic dissection (HP:0002647)2.60455767
20Bowel diverticulosis (HP:0005222)2.59105851
21Dilatation of the ascending aorta (HP:0005111)2.56811957
22Flat acetabular roof (HP:0003180)2.53288060
23Distal lower limb amyotrophy (HP:0008944)2.51926608
24Hemorrhage of the eye (HP:0011885)2.51907401
25Aortic aneurysm (HP:0004942)2.51560846
26Genu recurvatum (HP:0002816)2.50931133
27Deviation of the hallux (HP:0010051)2.38990599
28Fragile skin (HP:0001030)2.37803581
29Lymphangioma (HP:0100764)2.36845509
30Peritonitis (HP:0002586)2.33625998
31Hallux valgus (HP:0001822)2.32425868
32Increased connective tissue (HP:0009025)2.30512369
33Aneurysm (HP:0002617)2.29373347
34Distal upper limb amyotrophy (HP:0007149)2.27868654
35Upper limb amyotrophy (HP:0009129)2.27868654
36Ulnar bowing (HP:0003031)2.26251002
37Overriding aorta (HP:0002623)2.26133920
38Turricephaly (HP:0000262)2.25694732
39Flat cornea (HP:0007720)2.24299905
40Macroorchidism (HP:0000053)2.22867764
41Insomnia (HP:0100785)2.21209880
42J-shaped sella turcica (HP:0002680)2.16815633
43Enlarged penis (HP:0000040)2.15119949
44Mildly elevated creatine phosphokinase (HP:0008180)2.12846237
45Type 1 muscle fiber predominance (HP:0003803)2.09138801
46Pointed chin (HP:0000307)2.07019105
47Wrist flexion contracture (HP:0001239)2.06871731
48Hand muscle atrophy (HP:0009130)2.03241021
49Advanced eruption of teeth (HP:0006288)2.00778908
50Biconcave vertebral bodies (HP:0004586)2.00351924
51Increased density of long bones (HP:0006392)1.97950478
52Stridor (HP:0010307)1.97654438
53Aortic regurgitation (HP:0001659)1.96431019
54Dislocated radial head (HP:0003083)1.95166213
55Abnormality of the radial head (HP:0003995)1.94518049
56Premature skin wrinkling (HP:0100678)1.93920250
57Disproportionate tall stature (HP:0001519)1.92693307
58Long palpebral fissure (HP:0000637)1.92519436
59Thin bony cortex (HP:0002753)1.92398401
60Abnormality of the thoracic spine (HP:0100711)1.91504601
61Overgrowth (HP:0001548)1.90782285
62Neonatal short-limb short stature (HP:0008921)1.89711688
63Bronchomalacia (HP:0002780)1.89348971
64Cervical subluxation (HP:0003308)1.89176773
65Narrow palate (HP:0000189)1.88144812
66Buphthalmos (HP:0000557)1.87433873
67Subacute progressive viral hepatitis (HP:0006572)1.86362295
68Rectal prolapse (HP:0002035)1.86067695
69Blue sclerae (HP:0000592)1.85375458
70Milia (HP:0001056)1.83319459
71Increased variability in muscle fiber diameter (HP:0003557)1.82179500
72Arnold-Chiari malformation (HP:0002308)1.81780379
73Joint stiffness (HP:0001387)1.81245439
74Long toe (HP:0010511)1.80452453
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80428830
76Urethral obstruction (HP:0000796)1.79442671
77Broad thumb (HP:0011304)1.79270496
78Absent frontal sinuses (HP:0002688)1.78985612
79Joint laxity (HP:0001388)1.78336664
80Easy fatigability (HP:0003388)1.78207779
81Ankyloglossia (HP:0010296)1.77249667
82Natal tooth (HP:0000695)1.76480679
83Spondylolisthesis (HP:0003302)1.76025921
84Wide anterior fontanel (HP:0000260)1.75225433
85Syringomyelia (HP:0003396)1.74926346
86Spinal cord lesions (HP:0100561)1.74926346
87Lower limb amyotrophy (HP:0007210)1.74722952
88Thin ribs (HP:0000883)1.74716462
89Coronal craniosynostosis (HP:0004440)1.73956723
90Neoplasm of the heart (HP:0100544)1.72901726
91Patellar dislocation (HP:0002999)1.72739346
92Deformed sella turcica (HP:0002681)1.71963184
93Metaphyseal cupping (HP:0003021)1.71281153
94Distal lower limb muscle weakness (HP:0009053)1.70641842
95Bowed forearm bones (HP:0003956)1.69870307
96Bowing of the arm (HP:0006488)1.69870307
97Hepatoblastoma (HP:0002884)1.69868942
98Interstitial pulmonary disease (HP:0006530)1.69799473
99Camptodactyly of toe (HP:0001836)1.69750051
100Germ cell neoplasia (HP:0100728)1.69571083
101Hyperextensible skin (HP:0000974)1.69324927
102Precocious puberty (HP:0000826)1.67265444
103Abnormal vertebral ossification (HP:0100569)1.66919996
104Annular pancreas (HP:0001734)1.66836288
105Spinal rigidity (HP:0003306)1.66547922
106Striae distensae (HP:0001065)1.66447659
107Trigonocephaly (HP:0000243)1.66437474
108Abnormality of oral frenula (HP:0000190)1.65357484
109Slender build (HP:0001533)1.64867689
110Follicular hyperkeratosis (HP:0007502)1.64720815
111Short nail (HP:0001799)1.64496623
112Scapular winging (HP:0003691)1.63572510
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.63498436
114Persistence of primary teeth (HP:0006335)1.62941760
115Sparse lateral eyebrow (HP:0005338)1.62778480
116Asymmetry of the thorax (HP:0001555)1.62354080
117Tibial bowing (HP:0002982)1.62078081
118Dysostosis multiplex (HP:0000943)1.61285708
119Cellulitis (HP:0100658)1.61072626
120Difficulty climbing stairs (HP:0003551)1.60353646
121Urinary glycosaminoglycan excretion (HP:0003541)1.60282363
122Mucopolysacchariduria (HP:0008155)1.60282363
123Wormian bones (HP:0002645)1.60096183
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59291189
125Mitral regurgitation (HP:0001653)1.59288419
126Vascular tortuosity (HP:0004948)1.58915119
127Obstructive sleep apnea (HP:0002870)1.58727034
128Arterial tortuosity (HP:0005116)1.58665090
129Abnormality of the aortic arch (HP:0012303)1.58221089
130Heterotopia (HP:0002282)1.58122457
131Broad long bones (HP:0005622)1.58052712
132Difficulty running (HP:0009046)1.57915837
133Onion bulb formation (HP:0003383)1.56789004
134Radial bowing (HP:0002986)1.56680032
135Abnormality of the diencephalon (HP:0010662)1.56196125
136Ureteral stenosis (HP:0000071)1.56141848
137Long eyelashes (HP:0000527)1.55969565
138Soft skin (HP:0000977)1.55934087
139Thoracic kyphosis (HP:0002942)1.55324298
140Abnormal ossification of hand bones (HP:0005921)1.52625627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.48333437
2MAP3K103.19411408
3PKN23.13241824
4EPHA23.02952634
5EEF2K2.92994110
6RIPK12.90532112
7TTN2.63618412
8MST1R2.58188808
9ICK2.50707420
10DDR22.40986562
11PDGFRA2.40523368
12SMG12.35750857
13SIK12.29049580
14PRPF4B2.23214402
15CDK122.21659756
16PTK62.20973488
17SIK22.16552279
18EPHB21.98919537
19ERN11.91145605
20LATS11.87406155
21CAMK1G1.77583020
22LATS21.71691268
23PRKD31.63873043
24BMX1.58124665
25DMPK1.57304381
26CAMK1D1.51674013
27IRAK31.51428868
28MARK11.41494303
29TYRO31.39693048
30MTOR1.39261253
31TAOK11.39033265
32TNK21.31664923
33PTK21.23275370
34PAK21.22899902
35ALK1.22439902
36MAP3K61.22035470
37EPHB11.20660746
38MET1.19047673
39MAP2K31.17628657
40MAPK151.16032330
41PAK41.11455808
42PAK61.11356779
43PDGFRB1.06646560
44MAP3K71.02878720
45LMTK21.01055594
46CAMKK10.98747301
47MAP3K90.97861937
48MAP4K10.97856989
49PRKCH0.95886939
50MARK20.95424385
51CDC42BPA0.93989629
52RET0.93946362
53PRKD20.92188124
54PDPK10.88832504
55MAP3K130.85630711
56CDK60.84952494
57FGFR20.83961432
58ZAP700.82849262
59DAPK20.80841708
60MAP3K30.79817656
61FGFR40.79235430
62LRRK20.78959364
63FGFR30.78649530
64RPS6KA20.77811288
65FGFR10.77800325
66NTRK20.75713656
67NTRK10.75442750
68ERBB20.73593823
69DYRK1B0.73356874
70STK380.71439006
71TGFBR20.70188009
72FER0.68202104
73PAK30.66682603
74MAPKAPK30.65199303
75MAP3K10.64673939
76STK30.63283310
77MAP2K20.63097034
78IRAK20.62453585
79IRAK40.62361100
80PRKD10.61719852
81STK110.59862830
82BLK0.59438420
83MAP3K110.59337848
84MAPK110.58343866
85MAPK70.58290516
86PHKG10.58191285
87PHKG20.58191285
88JAK10.58083175
89TBK10.54691325
90ROCK10.54393972
91SGK30.53750322
92PTK2B0.52336346
93EPHA30.52254643
94KSR20.52066042
95TESK10.52006387
96HCK0.50967818
97RPS6KA10.50561169
98ILK0.50477433
99KIT0.50111606
100NEK20.49894139
101MAPK120.48772896
102BTK0.48715889
103RIPK40.48022543
104CHUK0.47184852
105CAMK40.45253818
106KSR10.44259428
107SRC0.44249790
108BRD40.41706077
109SIK30.41249039
110TYK20.41240508
111CSK0.40289637
112PDK10.39751296
113HIPK20.39662862
114MAPK80.39457203
115MAPKAPK20.39216010
116CDK40.38789063
117MAP2K60.38657177
118FYN0.37803323
119STK100.37087928
120CSF1R0.36340986
121MAP3K140.35616986
122SCYL20.35423846
123RPS6KL10.35277031
124RPS6KC10.35277031
125FES0.34876307
126PRKAA10.34658809
127WNK10.34262063
128GSK3A0.34140091
129TRPM70.34067229
130PRKCZ0.33123099
131PRKAA20.33037645
132CLK10.30460488
133RPS6KA60.30446435
134MAP3K20.30387534
135GRK60.30372621
136RPS6KB20.30332878
137MAPK10.30103229
138MATK0.29855312
139EGFR0.29789587

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.13129065
2Chronic myeloid leukemia_Homo sapiens_hsa052201.71242976
3Focal adhesion_Homo sapiens_hsa045101.69531701
4ECM-receptor interaction_Homo sapiens_hsa045121.63986845
5Proteoglycans in cancer_Homo sapiens_hsa052051.54485144
6Basal cell carcinoma_Homo sapiens_hsa052171.50115826
7Notch signaling pathway_Homo sapiens_hsa043301.47024500
8Adherens junction_Homo sapiens_hsa045201.46871901
9mTOR signaling pathway_Homo sapiens_hsa041501.45598009
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.44369932
11Endometrial cancer_Homo sapiens_hsa052131.43440312
12Glioma_Homo sapiens_hsa052141.42317068
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40068431
14Lysine degradation_Homo sapiens_hsa003101.40052400
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38124795
16Amoebiasis_Homo sapiens_hsa051461.36430859
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35593767
18Dilated cardiomyopathy_Homo sapiens_hsa054141.34730772
19Type II diabetes mellitus_Homo sapiens_hsa049301.32889092
20Hippo signaling pathway_Homo sapiens_hsa043901.27878118
21Small cell lung cancer_Homo sapiens_hsa052221.27693889
22Axon guidance_Homo sapiens_hsa043601.27681961
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27626564
24Dorso-ventral axis formation_Homo sapiens_hsa043201.27557534
25Estrogen signaling pathway_Homo sapiens_hsa049151.25646721
26MicroRNAs in cancer_Homo sapiens_hsa052061.23799812
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.22322003
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19989092
29Viral myocarditis_Homo sapiens_hsa054161.19207050
30Colorectal cancer_Homo sapiens_hsa052101.17580155
31Non-small cell lung cancer_Homo sapiens_hsa052231.16375928
32Hedgehog signaling pathway_Homo sapiens_hsa043401.14328162
33Protein digestion and absorption_Homo sapiens_hsa049741.13242385
34Pancreatic cancer_Homo sapiens_hsa052121.12710202
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12390626
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11264912
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10967777
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10580929
39VEGF signaling pathway_Homo sapiens_hsa043701.09887792
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09564865
41Insulin resistance_Homo sapiens_hsa049311.09279843
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08780440
43Bladder cancer_Homo sapiens_hsa052191.07262570
44Renal cell carcinoma_Homo sapiens_hsa052111.06680590
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06464507
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06322131
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05877033
48Inositol phosphate metabolism_Homo sapiens_hsa005621.05608393
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04019341
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03516705
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03265399
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.01454370
53ErbB signaling pathway_Homo sapiens_hsa040121.01355915
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00463174
55GnRH signaling pathway_Homo sapiens_hsa049120.97723200
56Acute myeloid leukemia_Homo sapiens_hsa052210.96888566
57Platelet activation_Homo sapiens_hsa046110.95556653
58Rap1 signaling pathway_Homo sapiens_hsa040150.95094433
59Melanogenesis_Homo sapiens_hsa049160.94508820
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94398193
61Toxoplasmosis_Homo sapiens_hsa051450.94336254
62Hepatitis C_Homo sapiens_hsa051600.94292827
63Insulin signaling pathway_Homo sapiens_hsa049100.93215494
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92795227
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.92616703
66B cell receptor signaling pathway_Homo sapiens_hsa046620.92525155
67Gap junction_Homo sapiens_hsa045400.92133973
68Wnt signaling pathway_Homo sapiens_hsa043100.89731785
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.88040566
70Gastric acid secretion_Homo sapiens_hsa049710.87671145
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86997671
72Osteoclast differentiation_Homo sapiens_hsa043800.86300309
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.85966423
74Prolactin signaling pathway_Homo sapiens_hsa049170.85053763
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84491131
76Oxytocin signaling pathway_Homo sapiens_hsa049210.84094769
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84086954
78Pathways in cancer_Homo sapiens_hsa052000.84062092
79AMPK signaling pathway_Homo sapiens_hsa041520.82644858
80Renin secretion_Homo sapiens_hsa049240.80707020
81Tight junction_Homo sapiens_hsa045300.80408651
82Prion diseases_Homo sapiens_hsa050200.79465072
83Thyroid cancer_Homo sapiens_hsa052160.77332502
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76684039
85Prostate cancer_Homo sapiens_hsa052150.76627280
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75921687
87T cell receptor signaling pathway_Homo sapiens_hsa046600.75510888
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74995918
89MAPK signaling pathway_Homo sapiens_hsa040100.74304089
90Choline metabolism in cancer_Homo sapiens_hsa052310.72854483
91FoxO signaling pathway_Homo sapiens_hsa040680.72519450
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71543773
93HTLV-I infection_Homo sapiens_hsa051660.71129234
94Endocytosis_Homo sapiens_hsa041440.70767859
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70684468
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.70459000
97Cholinergic synapse_Homo sapiens_hsa047250.68031193
98Salivary secretion_Homo sapiens_hsa049700.67109308
99cAMP signaling pathway_Homo sapiens_hsa040240.66722206
100TGF-beta signaling pathway_Homo sapiens_hsa043500.66634858
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.65183412
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65119271
103Circadian entrainment_Homo sapiens_hsa047130.65064141
104TNF signaling pathway_Homo sapiens_hsa046680.64360969
105Melanoma_Homo sapiens_hsa052180.62737484
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.61906559
107ABC transporters_Homo sapiens_hsa020100.61809329
108Chemokine signaling pathway_Homo sapiens_hsa040620.61577862
109Influenza A_Homo sapiens_hsa051640.61170240
110Long-term potentiation_Homo sapiens_hsa047200.61078812
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59897484
112Cocaine addiction_Homo sapiens_hsa050300.59628610
113Apoptosis_Homo sapiens_hsa042100.59388656
114Leishmaniasis_Homo sapiens_hsa051400.59156240
115Glucagon signaling pathway_Homo sapiens_hsa049220.57784004
116Hepatitis B_Homo sapiens_hsa051610.57241997
117Fructose and mannose metabolism_Homo sapiens_hsa000510.56757613
118Thyroid hormone synthesis_Homo sapiens_hsa049180.56593841
119Bile secretion_Homo sapiens_hsa049760.56568043
120Lysosome_Homo sapiens_hsa041420.54767327

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