ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of cellular amide metabolic process (GO:0034250)	4.54829681
2	regulation of cell proliferation involved in kidney development (GO:1901722)	4.38215757
3	histone H3-K36 demethylation (GO:0070544)	4.20610344
4	keratinization (GO:0031424)	4.10159759
5	regulation of histone H3-K27 methylation (GO:0061085)	3.43831162
6	cellular response to ethanol (GO:0071361)	3.32334287
7	regulation of Cdc42 GTPase activity (GO:0043088)	3.17156971
8	regulation of establishment of cell polarity (GO:2000114)	3.16880805
9	positive regulation of keratinocyte differentiation (GO:0045618)	3.13786389
10	interferon-gamma secretion (GO:0072643)	3.11914773
11	ear development (GO:0043583)	3.10846882
12	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	3.02767684
13	histone H3-K4 trimethylation (GO:0080182)	3.02638926
14	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.99634579
15	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.98271210
16	regulation of MHC class I biosynthetic process (GO:0045343)	2.96285892
17	positive regulation of humoral immune response (GO:0002922)	2.92488415
18	establishment of skin barrier (GO:0061436)	2.88709474
19	histone lysine demethylation (GO:0070076)	2.87059673
20	activation of Rac GTPase activity (GO:0032863)	2.83922794
21	regulation of water loss via skin (GO:0033561)	2.79858739
22	regulation of T-helper 2 cell differentiation (GO:0045628)	2.79671350
23	negative regulation of osteoblast proliferation (GO:0033689)	2.79391817
24	striated muscle atrophy (GO:0014891)	2.77655353
25	semaphorin-plexin signaling pathway (GO:0071526)	2.77444149
26	histone demethylation (GO:0016577)	2.75687016
27	protein K11-linked deubiquitination (GO:0035871)	2.68416096
28	positive regulation of histone deacetylation (GO:0031065)	2.67973368
29	mannose metabolic process (GO:0006013)	2.66717271
30	macrophage activation involved in immune response (GO:0002281)	2.61904222
31	negative regulation of interleukin-8 production (GO:0032717)	2.61628138
32	macroautophagy (GO:0016236)	2.60890915
33	histone H3-K4 methylation (GO:0051568)	2.58492837
34	positive regulation of Rac GTPase activity (GO:0032855)	2.57859543
35	endothelial cell chemotaxis (GO:0035767)	2.55822859
36	negative regulation of granulocyte differentiation (GO:0030853)	2.54331593
37	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.51608981
38	positive regulation of cholesterol efflux (GO:0010875)	2.50963532
39	positive regulation of protein kinase C signaling (GO:0090037)	2.50382326
40	skeletal muscle adaptation (GO:0043501)	2.48766906
41	histone H3-K9 demethylation (GO:0033169)	2.48492652
42	regulation of ruffle assembly (GO:1900027)	2.47823349
43	filopodium assembly (GO:0046847)	2.47558002
44	adherens junction assembly (GO:0034333)	2.43746736
45	snRNA transcription (GO:0009301)	2.43525332
46	cell-cell junction maintenance (GO:0045217)	2.43503922
47	intracellular estrogen receptor signaling pathway (GO:0030520)	2.43197004
48	positive regulation of epidermis development (GO:0045684)	2.43029126
49	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.38944516
50	detection of molecule of bacterial origin (GO:0032490)	2.38789442
51	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.36193169
52	positive regulation of glomerulus development (GO:0090193)	2.36070055
53	protein K48-linked deubiquitination (GO:0071108)	2.35887435
54	positive regulation of Rho GTPase activity (GO:0032321)	2.35784775
55	ovulation (GO:0030728)	2.34347667
56	regulation of ARF GTPase activity (GO:0032312)	2.34292008
57	positive regulation of p38MAPK cascade (GO:1900745)	2.33876719
58	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.33527143
59	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.32272015
60	protein dealkylation (GO:0008214)	2.30803433
61	protein demethylation (GO:0006482)	2.30803433
62	response to peptidoglycan (GO:0032494)	2.29464388
63	regulation of cellular amide metabolic process (GO:0034248)	2.28683231
64	negative regulation of cell size (GO:0045792)	2.27811414
65	regulation of fatty acid beta-oxidation (GO:0031998)	2.27712819
66	negative regulation of fatty acid transport (GO:2000192)	2.26397408
67	embryonic camera-type eye morphogenesis (GO:0048596)	2.25944757
68	receptor catabolic process (GO:0032801)	2.25362249
69	white fat cell differentiation (GO:0050872)	2.25283106
70	positive regulation of type 2 immune response (GO:0002830)	2.25241356
71	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.25055017
72	regulation of ARF protein signal transduction (GO:0032012)	2.24467564
73	cell-substrate adherens junction assembly (GO:0007045)	2.23874910
74	focal adhesion assembly (GO:0048041)	2.23874910
75	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.23732157
76	regulation of p38MAPK cascade (GO:1900744)	2.23552371
77	corticosteroid receptor signaling pathway (GO:0031958)	2.22877057
78	positive regulation of epidermal cell differentiation (GO:0045606)	2.22327961
79	positive regulation of protein deacetylation (GO:0090312)	2.22243386
80	positive regulation of receptor recycling (GO:0001921)	2.20398153
81	regulation of histone deacetylation (GO:0031063)	2.19424851
82	response to muramyl dipeptide (GO:0032495)	2.17484173
83	peptidyl-lysine trimethylation (GO:0018023)	2.17443633
84	TOR signaling (GO:0031929)	2.17191352
85	establishment of protein localization to Golgi (GO:0072600)	2.15642814
86	histone lysine methylation (GO:0034968)	2.15332095
87	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.15123175
88	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.13582977
89	fibroblast migration (GO:0010761)	2.13238656
90	positive regulation of macroautophagy (GO:0016239)	2.13137605
91	positive regulation of osteoblast proliferation (GO:0033690)	2.12691853
92	germinal center formation (GO:0002467)	2.12120612
93	regulation of transforming growth factor beta1 production (GO:0032908)	2.11032156
94	T-helper cell differentiation (GO:0042093)	2.10896143
95	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.10896143
96	phosphatidylinositol 3-kinase signaling (GO:0014065)	2.10494662
97	regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	2.10084726
98	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.09774744
99	angiogenesis involved in wound healing (GO:0060055)	2.09602587
100	macrophage activation (GO:0042116)	2.08758061

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.29074778
2	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.71611478
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.00116414
4	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.83568201
5	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.66033551
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.53587449
7	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.51887482
8	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.45055463
9	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.41987434
10	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.39076118
11	AHR_22903824_ChIP-Seq_MCF-7_Human	2.37744214
12	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.31378724
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.26856421
14	DROSHA_22980978_ChIP-Seq_HELA_Human	2.24569222
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.19042371
16	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.16170227
17	TCF7_22412390_ChIP-Seq_EML_Mouse	2.06137457
18	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.95767426
19	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.86832997
20	RACK7_27058665_Chip-Seq_MCF-7_Human	1.81481588
21	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.80907248
22	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.80432897
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.75137632
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.74217835
25	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.73751420
26	KDM2B_26808549_Chip-Seq_DND41_Human	1.73748733
27	VDR_21846776_ChIP-Seq_THP-1_Human	1.72348322
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.70191751
29	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.69866338
30	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.66752893
31	MYC_22102868_ChIP-Seq_BL_Human	1.64441521
32	KDM2B_26808549_Chip-Seq_K562_Human	1.63738852
33	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.63305773
34	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.62684271
35	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.58908998
36	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.56044903
37	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.56023271
38	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.52732467
39	SPI1_23127762_ChIP-Seq_K562_Human	1.52551643
40	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.51052879
41	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.48180030
42	VDR_24763502_ChIP-Seq_THP-1_Human	1.46584257
43	LXR_22292898_ChIP-Seq_THP-1_Human	1.45426122
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.42175726
45	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.41793848
46	SCL_19346495_ChIP-Seq_HPC-7_Human	1.36407642
47	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.36235222
48	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.35106347
49	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.32279819
50	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.30712483
51	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.29815982
52	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.29775858
53	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.26151156
54	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.26035953
55	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.24654994
56	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.24083137
57	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.23391235
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.21913986
59	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.21084433
60	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.21084433
61	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.19772545
62	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.19771106
63	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.18026755
64	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.17914441
65	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16266425
66	TP53_22127205_ChIP-Seq_IMR90_Human	1.12778374
67	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.11708943
68	TP53_16413492_ChIP-PET_HCT116_Human	1.11057013
69	MAF_26560356_Chip-Seq_TH1_Human	1.09049659
70	CREB1_26743006_Chip-Seq_LNCaP_Human	1.08648038
71	VDR_24787735_ChIP-Seq_THP-1_Human	1.08340507
72	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07182163
73	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.07005645
74	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.06441991
75	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.04899083
76	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.04393847
77	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.04287748
78	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02775982
79	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.02227870
80	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01786010
81	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00915394
82	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.98778463
83	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98739758
84	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98429139
85	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.97696009
86	KLF5_25053715_ChIP-Seq_YYC3_Human	0.96955112
87	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96717828
88	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96473892
89	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.95413940
90	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.95065298
91	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91321068
92	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.90779102
93	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.89988911
94	TP63_22573176_ChIP-Seq_HFKS_Human	0.89160006
95	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.88405558
96	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.87875161
97	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.87239041
98	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.86919377
99	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.86386366
100	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.85245448

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004381_abnormal_hair_follicle	3.81140094
2	MP0005076_abnormal_cell_differentiation	3.55901124
3	MP0002796_impaired_skin_barrier	3.02044100
4	MP0003705_abnormal_hypodermis_morpholog	2.90872989
5	MP0000383_abnormal_hair_follicle	2.76484755
6	MP0005409_darkened_coat_color	2.66027464
7	MP0003183_abnormal_peptide_metabolism	2.50944913
8	MP0005058_abnormal_lysosome_morphology	2.48439649
9	MP0003172_abnormal_lysosome_physiology	2.42312487
10	MP0005451_abnormal_body_composition	2.40765721
11	MP0010678_abnormal_skin_adnexa	2.36375313
12	MP0003303_peritoneal_inflammation	2.32327543
13	MP0002009_preneoplasia	2.29543735
14	MP0005167_abnormal_blood-brain_barrier	2.12974813
15	MP0005310_abnormal_salivary_gland	2.08120235
16	MP0003453_abnormal_keratinocyte_physiol	2.01564122
17	MP0009278_abnormal_bone_marrow	2.00116239
18	MP0010234_abnormal_vibrissa_follicle	1.96972720
19	MP0000371_diluted_coat_color	1.93365643
20	MP0000569_abnormal_digit_pigmentation	1.91108091
21	MP0004510_myositis	1.90393460
22	MP0003191_abnormal_cellular_cholesterol	1.89802432
23	MP0003091_abnormal_cell_migration	1.79951449
24	MP0000767_abnormal_smooth_muscle	1.74195343
25	MP0008961_abnormal_basal_metabolism	1.72967370
26	MP0004947_skin_inflammation	1.69423685
27	MP0001873_stomach_inflammation	1.65849119
28	MP0002254_reproductive_system_inflammat	1.63961611
29	MP0008260_abnormal_autophagy	1.61102509
30	MP0002998_abnormal_bone_remodeling	1.55175807
31	MP0005670_abnormal_white_adipose	1.53837557
32	MP0001849_ear_inflammation	1.47588237
33	MP0005501_abnormal_skin_physiology	1.42042559
34	MP0009115_abnormal_fat_cell	1.40648638
35	MP0002098_abnormal_vibrissa_morphology	1.38729942
36	MP0003436_decreased_susceptibility_to	1.36011416
37	MP0002332_abnormal_exercise_endurance	1.34011750
38	MP0005377_hearing/vestibular/ear_phenot	1.29081860
39	MP0003878_abnormal_ear_physiology	1.29081860
40	MP0001790_abnormal_immune_system	1.28116634
41	MP0005387_immune_system_phenotype	1.28116634
42	MP0001800_abnormal_humoral_immune	1.24640287
43	MP0005375_adipose_tissue_phenotype	1.22544986
44	MP0003656_abnormal_erythrocyte_physiolo	1.21330200
45	MP0002419_abnormal_innate_immunity	1.20831677
46	MP0001835_abnormal_antigen_presentation	1.20727317
47	MP0002970_abnormal_white_adipose	1.17923044
48	MP0004264_abnormal_extraembryonic_tissu	1.17048157
49	MP0001545_abnormal_hematopoietic_system	1.16857317
50	MP0005397_hematopoietic_system_phenotyp	1.16857317
51	MP0002452_abnormal_antigen_presenting	1.14975860
52	MP0004233_abnormal_muscle_weight	1.12287836
53	MP0005647_abnormal_sex_gland	1.11272347
54	MP0006082_CNS_inflammation	1.10189032
55	MP0003279_aneurysm	1.07771903
56	MP0000003_abnormal_adipose_tissue	1.07192054
57	MP0000249_abnormal_blood_vessel	1.07106192
58	MP0005666_abnormal_adipose_tissue	1.06764938
59	MP0003045_fibrosis	1.02058791
60	MP0004808_abnormal_hematopoietic_stem	1.01574484
61	MP0004883_abnormal_blood_vessel	1.00200548
62	MP0005000_abnormal_immune_tolerance	0.99853123
63	MP0005025_abnormal_response_to	0.98315720
64	MP0000015_abnormal_ear_pigmentation	0.96069424
65	MP0003828_pulmonary_edema	0.95888242
66	MP0002723_abnormal_immune_serum	0.94948169
67	MP0003300_gastrointestinal_ulcer	0.94128487
68	MP0009384_cardiac_valve_regurgitation	0.94014561
69	MP0003724_increased_susceptibility_to	0.93818946
70	MP0009840_abnormal_foam_cell	0.91298732
71	MP0005083_abnormal_biliary_tract	0.90715705
72	MP0002060_abnormal_skin_morphology	0.89540096
73	MP0002933_joint_inflammation	0.89406717
74	MP0008057_abnormal_DNA_replication	0.89112422
75	MP0005275_abnormal_skin_tensile	0.88973193
76	MP0000377_abnormal_hair_follicle	0.88316842
77	MP0002896_abnormal_bone_mineralization	0.87936339
78	MP0005075_abnormal_melanosome_morpholog	0.87418693
79	MP0001533_abnormal_skeleton_physiology	0.87170632
80	MP0000733_abnormal_muscle_development	0.86669936
81	MP0002075_abnormal_coat/hair_pigmentati	0.85661495
82	MP0009931_abnormal_skin_appearance	0.84373497
83	MP0000427_abnormal_hair_cycle	0.83902537
84	MP0005248_abnormal_Harderian_gland	0.82123473
85	MP0003566_abnormal_cell_adhesion	0.79876390
86	MP0000678_abnormal_parathyroid_gland	0.79475241
87	MP0005621_abnormal_cell_physiology	0.77380185
88	MP0010771_integument_phenotype	0.75607021
89	MP0001819_abnormal_immune_cell	0.74942902
90	MP0001851_eye_inflammation	0.74715505
91	MP0004043_abnormal_pH_regulation	0.73884069
92	MP0002420_abnormal_adaptive_immunity	0.73695203
93	MP0001216_abnormal_epidermal_layer	0.73302939
94	MP0002971_abnormal_brown_adipose	0.72448392
95	MP0005334_abnormal_fat_pad	0.72079316
96	MP0005595_abnormal_vascular_smooth	0.71707142
97	MP0005023_abnormal_wound_healing	0.71335367
98	MP0003948_abnormal_gas_homeostasis	0.68974768
99	MP0005464_abnormal_platelet_physiology	0.67754600
100	MP0005448_abnormal_energy_balance	0.67712977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	J-shaped sella turcica (HP:0002680)	4.32491599
2	Deformed sella turcica (HP:0002681)	3.73796431
3	Broad face (HP:0000283)	3.60904692
4	Abnormality of nail color (HP:0100643)	3.51913651
5	Sparse lateral eyebrow (HP:0005338)	3.45115517
6	Abnormality of the sella turcica (HP:0002679)	3.22939003
7	Cerebral aneurysm (HP:0004944)	3.22256807
8	Genetic anticipation (HP:0003743)	3.16899633
9	Abnormality of the fingertips (HP:0001211)	3.15916587
10	Hyperacusis (HP:0010780)	3.00669840
11	Increased cerebral lipofuscin (HP:0011813)	2.99000769
12	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.83131697
13	Lip pit (HP:0100267)	2.78889758
14	Urinary glycosaminoglycan excretion (HP:0003541)	2.72185973
15	Mucopolysacchariduria (HP:0008155)	2.72185973
16	Colitis (HP:0002583)	2.70766899
17	Obstructive sleep apnea (HP:0002870)	2.68647659
18	Cervical subluxation (HP:0003308)	2.68220049
19	Absent frontal sinuses (HP:0002688)	2.66362887
20	Abnormality of polysaccharide metabolism (HP:0011012)	2.65517592
21	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.65517592
22	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.65517592
23	Parakeratosis (HP:0001036)	2.53426828
24	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.46853424
25	Narrow palate (HP:0000189)	2.44104647
26	Loss of speech (HP:0002371)	2.43467500
27	Dysostosis multiplex (HP:0000943)	2.40632456
28	Thin bony cortex (HP:0002753)	2.39183955
29	Increased IgE level (HP:0003212)	2.38111384
30	Glomerulonephritis (HP:0000099)	2.28349623
31	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.27214999
32	Flat acetabular roof (HP:0003180)	2.26887478
33	Long eyelashes (HP:0000527)	2.26769211
34	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.26491467
35	Germ cell neoplasia (HP:0100728)	2.18824896
36	Abnormality of the epiphyses of the hand (HP:0005924)	2.13036297
37	Thick nail (HP:0001805)	2.09086314
38	Syringomyelia (HP:0003396)	2.08690953
39	Spinal cord lesions (HP:0100561)	2.08690953
40	Lymphangioma (HP:0100764)	2.08549864
41	Dysmetric saccades (HP:0000641)	2.07643138
42	Optic neuritis (HP:0100653)	2.06268737
43	Retrobulbar optic neuritis (HP:0100654)	2.06268737
44	Esophageal varix (HP:0002040)	2.05602352
45	Laryngomalacia (HP:0001601)	2.05490781
46	Abnormality of the thoracic spine (HP:0100711)	2.00751901
47	Urethral obstruction (HP:0000796)	2.00012332
48	Septate vagina (HP:0001153)	1.97365913
49	Nuclear cataract (HP:0100018)	1.96399775
50	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.94669117
51	Orchitis (HP:0100796)	1.92793085
52	Persistence of primary teeth (HP:0006335)	1.91625347
53	Distal lower limb amyotrophy (HP:0008944)	1.88861203
54	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.88002400
55	Concave nail (HP:0001598)	1.87376387
56	Macroorchidism (HP:0000053)	1.85768578
57	Distal lower limb muscle weakness (HP:0009053)	1.85264590
58	Autoimmune thrombocytopenia (HP:0001973)	1.85196112
59	Hemorrhage of the eye (HP:0011885)	1.85002798
60	Recurrent cutaneous fungal infections (HP:0011370)	1.82588356
61	Chronic mucocutaneous candidiasis (HP:0002728)	1.82588356
62	Deep philtrum (HP:0002002)	1.82397590
63	Neuronal loss in central nervous system (HP:0002529)	1.81392726
64	Abnormality of the radial head (HP:0003995)	1.81122739
65	Hypopigmentation of the fundus (HP:0007894)	1.80930097
66	Cone-rod dystrophy (HP:0000548)	1.80251909
67	Spondylolisthesis (HP:0003302)	1.78841749
68	Bilateral sensorineural hearing impairment (HP:0008619)	1.77369070
69	Ocular albinism (HP:0001107)	1.73717259
70	Recurrent bacterial skin infections (HP:0005406)	1.72690864
71	Long toe (HP:0010511)	1.72489018
72	Thick eyebrow (HP:0000574)	1.71922755
73	Hyperkalemia (HP:0002153)	1.71482896
74	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.70466147
75	Distal upper limb amyotrophy (HP:0007149)	1.70213569
76	Upper limb amyotrophy (HP:0009129)	1.70213569
77	Renovascular hypertension (HP:0100817)	1.69403406
78	Neonatal hypoglycemia (HP:0001998)	1.68123673
79	Dislocated radial head (HP:0003083)	1.68099518
80	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.67491191
81	Ectropion (HP:0000656)	1.67256868
82	Asymmetry of the thorax (HP:0001555)	1.65795542
83	Thoracic kyphosis (HP:0002942)	1.65382794
84	Mediastinal lymphadenopathy (HP:0100721)	1.64466336
85	Abnormality of the columella (HP:0009929)	1.63085584
86	Smooth philtrum (HP:0000319)	1.62503724
87	Prominent nose (HP:0000448)	1.61770289
88	Natal tooth (HP:0000695)	1.61348040
89	Precocious puberty (HP:0000826)	1.60434251
90	Vitreoretinal degeneration (HP:0000655)	1.59487762
91	Abnormality of glycolipid metabolism (HP:0010969)	1.59202552
92	Abnormality of liposaccharide metabolism (HP:0010968)	1.59202552
93	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.59202552
94	Hematochezia (HP:0002573)	1.58247655
95	Systemic lupus erythematosus (HP:0002725)	1.57949209
96	Advanced eruption of teeth (HP:0006288)	1.56314508
97	Neoplasm of the heart (HP:0100544)	1.56011063
98	Curly hair (HP:0002212)	1.55677106
99	Morphological abnormality of the middle ear (HP:0008609)	1.55055034
100	Slow saccadic eye movements (HP:0000514)	1.54391423

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.90368573
2	SIK1	3.75185717
3	PKN2	3.31368567
4	EPHA2	3.07670240
5	BLK	2.80919215
6	CDK12	2.79068056
7	AKT3	2.57040100
8	CHUK	2.00634131
9	ICK	1.85484502
10	RIPK1	1.80939727
11	CDC42BPA	1.70935913
12	CSF1R	1.69747833
13	ERN1	1.67880155
14	TNK2	1.53641177
15	MARK2	1.51370828
16	MTOR	1.48491219
17	MAPK15	1.44224547
18	IRAK3	1.44082298
19	IKBKE	1.39563594
20	MUSK	1.38326258
21	MAPKAPK3	1.32184860
22	RIPK4	1.30809637
23	FRK	1.28941163
24	TGFBR2	1.28019205
25	SGK2	1.27914171
26	EEF2K	1.27908013
27	NEK6	1.23911584
28	MAP4K1	1.20232462
29	CAMK1D	1.20078743
30	SGK3	1.19491153
31	CAMK1G	1.16030840
32	TBK1	1.07519040
33	MAP3K7	1.07044458
34	FGFR4	1.01870960
35	RPS6KA2	1.01499143
36	BMX	0.97535707
37	IKBKB	0.95808618
38	SIK2	0.92821238
39	PDPK1	0.92336718
40	JAK1	0.91114380
41	PDGFRB	0.87527459
42	PIK3CA	0.87262368
43	MAP3K6	0.86514492
44	ERBB2	0.86420823
45	RET	0.86370664
46	PDK1	0.86203101
47	MAP3K3	0.85830292
48	PRKD2	0.83758582
49	PIM2	0.81298815
50	MAPK7	0.81241156
51	RPS6KL1	0.79994491
52	RPS6KC1	0.79994491
53	PTK6	0.79461108
54	MAP3K13	0.79025041
55	BTK	0.79024094
56	FGR	0.77779950
57	PRPF4B	0.74374471
58	SGK223	0.73032381
59	SGK494	0.73032381
60	RPS6KA6	0.72821911
61	HIPK2	0.72201704
62	TYK2	0.70238476
63	BMPR2	0.70237637
64	BRD4	0.68641317
65	MAP2K3	0.68183609
66	MAP3K14	0.67812743
67	SMG1	0.66994063
68	PDGFRA	0.66756332
69	GRK6	0.66104076
70	CSK	0.64499090
71	CDK6	0.64199001
72	IRAK4	0.60088408
73	HCK	0.58043865
74	TYRO3	0.57803741
75	FER	0.57748792
76	TAOK1	0.56798568
77	MAPK8	0.56701760
78	PTK2	0.56101377
79	TTN	0.56039185
80	TRPM7	0.55900919
81	MAP3K10	0.53339022
82	TXK	0.53238621
83	MATK	0.52002577
84	PRKAA2	0.50690566
85	MELK	0.49714962
86	MAP3K1	0.48719276
87	MAPK11	0.48543189
88	JAK3	0.48064976
89	DYRK1B	0.47265188
90	RPS6KB2	0.46347906
91	MAPK10	0.45130777
92	MAP2K4	0.44417403
93	PRKAA1	0.43430174
94	CAMK4	0.43068884
95	IRAK2	0.43015535
96	RPS6KA1	0.41842710
97	MAPK1	0.41732571
98	PRKD1	0.41462436
99	IRAK1	0.41419047
100	ITK	0.41126239

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.82315494
2	Other glycan degradation_Homo sapiens_hsa00511	2.23284688
3	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.80391777
4	Notch signaling pathway_Homo sapiens_hsa04330	1.70239689
5	Acute myeloid leukemia_Homo sapiens_hsa05221	1.69475026
6	Osteoclast differentiation_Homo sapiens_hsa04380	1.59998177
7	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.59331624
8	Lysine degradation_Homo sapiens_hsa00310	1.55288424
9	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.54627439
10	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.46184169
11	mTOR signaling pathway_Homo sapiens_hsa04150	1.42954458
12	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.38466219
13	VEGF signaling pathway_Homo sapiens_hsa04370	1.37668718
14	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.37628287
15	TNF signaling pathway_Homo sapiens_hsa04668	1.36045598
16	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.35530325
17	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.35221238
18	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.32969867
19	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.28057849
20	Choline metabolism in cancer_Homo sapiens_hsa05231	1.27669778
21	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.25459713
22	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.24639429
23	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.22919604
24	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.22809978
25	Non-small cell lung cancer_Homo sapiens_hsa05223	1.22669072
26	ErbB signaling pathway_Homo sapiens_hsa04012	1.21806918
27	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.20224867
28	Toxoplasmosis_Homo sapiens_hsa05145	1.18990437
29	Estrogen signaling pathway_Homo sapiens_hsa04915	1.16539659
30	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.15848207
31	Hepatitis C_Homo sapiens_hsa05160	1.14284767
32	Insulin resistance_Homo sapiens_hsa04931	1.13474356
33	Prolactin signaling pathway_Homo sapiens_hsa04917	1.12717489
34	Leishmaniasis_Homo sapiens_hsa05140	1.12548972
35	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.10677462
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10590554
37	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.09934486
38	Lysosome_Homo sapiens_hsa04142	1.09711408
39	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.08652375
40	Endometrial cancer_Homo sapiens_hsa05213	1.07926459
41	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.07480326
42	GnRH signaling pathway_Homo sapiens_hsa04912	1.06933989
43	Influenza A_Homo sapiens_hsa05164	1.06857587
44	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06647891
45	Renal cell carcinoma_Homo sapiens_hsa05211	1.03329533
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02204423
47	Platelet activation_Homo sapiens_hsa04611	1.01659331
48	FoxO signaling pathway_Homo sapiens_hsa04068	0.99875103
49	Tuberculosis_Homo sapiens_hsa05152	0.98518603
50	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.98331698
51	Pancreatic cancer_Homo sapiens_hsa05212	0.94965979
52	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.94779406
53	Bladder cancer_Homo sapiens_hsa05219	0.91739416
54	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.91188706
55	Insulin signaling pathway_Homo sapiens_hsa04910	0.89602611
56	ABC transporters_Homo sapiens_hsa02010	0.89594448
57	Hepatitis B_Homo sapiens_hsa05161	0.87755443
58	Legionellosis_Homo sapiens_hsa05134	0.86263184
59	Pertussis_Homo sapiens_hsa05133	0.85174775
60	AMPK signaling pathway_Homo sapiens_hsa04152	0.84757910
61	Glioma_Homo sapiens_hsa05214	0.83481973
62	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.82673885
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.82426460
64	Malaria_Homo sapiens_hsa05144	0.82286627
65	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82016543
66	Prostate cancer_Homo sapiens_hsa05215	0.81060735
67	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.80456014
68	Proteoglycans in cancer_Homo sapiens_hsa05205	0.80052504
69	Chemokine signaling pathway_Homo sapiens_hsa04062	0.77755113
70	Focal adhesion_Homo sapiens_hsa04510	0.75796309
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.75012246
72	Amoebiasis_Homo sapiens_hsa05146	0.73705079
73	Small cell lung cancer_Homo sapiens_hsa05222	0.73511255
74	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.71936407
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71453578
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.70583289
77	Colorectal cancer_Homo sapiens_hsa05210	0.69972937
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68139594
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.67961189
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66727411
81	Rap1 signaling pathway_Homo sapiens_hsa04015	0.64682195
82	Apoptosis_Homo sapiens_hsa04210	0.63658651
83	Endocytosis_Homo sapiens_hsa04144	0.62966161
84	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.62743437
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60361493
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.59548147
87	Measles_Homo sapiens_hsa05162	0.59527418
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55804701
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54870886
90	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54602703
91	Thyroid cancer_Homo sapiens_hsa05216	0.54592718
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50463856
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50402297
94	Axon guidance_Homo sapiens_hsa04360	0.50399660
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49850368
96	Circadian rhythm_Homo sapiens_hsa04710	0.48335246
97	HTLV-I infection_Homo sapiens_hsa05166	0.48308727
98	Cholinergic synapse_Homo sapiens_hsa04725	0.47798096
99	African trypanosomiasis_Homo sapiens_hsa05143	0.46595320
100	Herpes simplex infection_Homo sapiens_hsa05168	0.45595483

TNRC18P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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