ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	serotonin receptor signaling pathway (GO:0007210)	6.11551106
2	rRNA methylation (GO:0031167)	5.17186822
3	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	5.03555906
4	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.91786353
5	neurofilament cytoskeleton organization (GO:0060052)	4.83945225
6	regulation of cilium movement (GO:0003352)	4.83543017
7	cellular ketone body metabolic process (GO:0046950)	4.62093968
8	acrosome reaction (GO:0007340)	4.51224460
9	rRNA modification (GO:0000154)	4.40377910
10	protein K11-linked deubiquitination (GO:0035871)	4.35326580
11	arginine metabolic process (GO:0006525)	4.21143968
12	regulation of appetite (GO:0032098)	4.14839329
13	glycerophospholipid catabolic process (GO:0046475)	4.07249593
14	ketone body metabolic process (GO:1902224)	4.04131594
15	protein polyglutamylation (GO:0018095)	3.88500464
16	organic cation transport (GO:0015695)	3.88015776
17	multicellular organism reproduction (GO:0032504)	3.78246780
18	sperm motility (GO:0030317)	3.74013809
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.70729954
20	epithelial cilium movement (GO:0003351)	3.65400790
21	activated T cell proliferation (GO:0050798)	3.59976854
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.59946581
23	growth hormone receptor signaling pathway (GO:0060396)	3.59545132
24	nonmotile primary cilium assembly (GO:0035058)	3.49271544
25	ganglion development (GO:0061548)	3.45695868
26	macroautophagy (GO:0016236)	3.40597841
27	establishment of protein localization to Golgi (GO:0072600)	3.39465938
28	negative regulation of appetite (GO:0032099)	3.38764378
29	negative regulation of response to food (GO:0032096)	3.38764378
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.33236972
31	L-alpha-amino acid transmembrane transport (GO:1902475)	3.32992830
32	reflex (GO:0060004)	3.29082351
33	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.27173014
34	detection of light stimulus involved in visual perception (GO:0050908)	3.25611957
35	detection of light stimulus involved in sensory perception (GO:0050962)	3.25611957
36	behavioral response to nicotine (GO:0035095)	3.25053070
37	arginine catabolic process (GO:0006527)	3.24583963
38	response to gravity (GO:0009629)	3.22777603
39	gamma-aminobutyric acid transport (GO:0015812)	3.22649959
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22613153
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22613153
42	NADH dehydrogenase complex assembly (GO:0010257)	3.22613153
43	brain morphogenesis (GO:0048854)	3.21555076
44	cellular response to growth hormone stimulus (GO:0071378)	3.14962641
45	axoneme assembly (GO:0035082)	3.14212261
46	protein targeting to Golgi (GO:0000042)	3.13463473
47	ovulation cycle (GO:0042698)	3.10504509
48	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.09592256
49	auditory receptor cell differentiation (GO:0042491)	3.07959095
50	protein K6-linked ubiquitination (GO:0085020)	3.07558271
51	regulation of microtubule-based movement (GO:0060632)	3.06892047
52	calcium ion-dependent exocytosis (GO:0017156)	3.06005656
53	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.03949639
54	sulfation (GO:0051923)	3.03573534
55	fusion of sperm to egg plasma membrane (GO:0007342)	3.03315146
56	regulation of hexokinase activity (GO:1903299)	2.97655106
57	regulation of glucokinase activity (GO:0033131)	2.97655106
58	startle response (GO:0001964)	2.93821931
59	positive regulation of meiosis (GO:0045836)	2.93657281
60	protein complex biogenesis (GO:0070271)	2.93590986
61	coenzyme catabolic process (GO:0009109)	2.93233016
62	reproduction (GO:0000003)	2.89564079
63	axonemal dynein complex assembly (GO:0070286)	2.87120602
64	peptidyl-glutamic acid modification (GO:0018200)	2.84326276
65	photoreceptor cell maintenance (GO:0045494)	2.83869239
66	pentose-phosphate shunt (GO:0006098)	2.83777878
67	piRNA metabolic process (GO:0034587)	2.82247820
68	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.82152795
69	cofactor catabolic process (GO:0051187)	2.76879831
70	platelet dense granule organization (GO:0060155)	2.74713091
71	DNA double-strand break processing (GO:0000729)	2.72716964
72	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.71638042
73	negative regulation of norepinephrine secretion (GO:0010700)	2.71631720
74	preassembly of GPI anchor in ER membrane (GO:0016254)	2.71137096
75	righting reflex (GO:0060013)	2.71054956
76	positive regulation of meiotic cell cycle (GO:0051446)	2.70850354
77	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66247543
78	hematopoietic stem cell proliferation (GO:0071425)	2.66163998
79	lipopolysaccharide biosynthetic process (GO:0009103)	2.63265329
80	negative regulation of interleukin-8 production (GO:0032717)	2.62200138
81	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61998910
82	synaptic transmission, glutamatergic (GO:0035249)	2.61191256
83	positive regulation of cAMP-mediated signaling (GO:0043950)	2.58807060
84	regulation of meiosis I (GO:0060631)	2.57974742
85	regulation of beta-amyloid formation (GO:1902003)	2.57792923
86	dendritic spine morphogenesis (GO:0060997)	2.57623320
87	motile cilium assembly (GO:0044458)	2.56963951
88	synaptic transmission, cholinergic (GO:0007271)	2.56723820
89	cilium movement (GO:0003341)	2.56676810
90	cellular response to ATP (GO:0071318)	2.55698805
91	C4-dicarboxylate transport (GO:0015740)	2.55211548
92	negative regulation of neurotransmitter transport (GO:0051589)	2.54702796
93	striatum development (GO:0021756)	2.54553026
94	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.54511783
95	suckling behavior (GO:0001967)	2.52186042
96	cellular response to leptin stimulus (GO:0044320)	2.51648828
97	positive regulation of action potential (GO:0045760)	2.50118412
98	response to pheromone (GO:0019236)	2.50069780
99	positive regulation of vasculogenesis (GO:2001214)	2.49952741
100	negative regulation of mast cell activation (GO:0033004)	2.48452463

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.51494464
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64854256
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.37365114
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17779027
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.12503765
6	TAF15_26573619_Chip-Seq_HEK293_Human	3.03425750
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80045807
8	VDR_22108803_ChIP-Seq_LS180_Human	2.55722502
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47726948
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.33947355
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.33410590
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31883839
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11690875
14	FUS_26573619_Chip-Seq_HEK293_Human	2.08586442
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01626306
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88237312
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81471518
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72700488
19	EWS_26573619_Chip-Seq_HEK293_Human	1.72441635
20	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.72387467
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.71771188
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71771188
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64288026
24	AR_25329375_ChIP-Seq_VCAP_Human	1.59055177
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.57761186
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.55873431
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53930833
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46865575
29	DROSHA_22980978_ChIP-Seq_HELA_Human	1.46047215
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40241124
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39186424
32	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.39059215
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37461018
34	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.33402346
35	P300_19829295_ChIP-Seq_ESCs_Human	1.32572296
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32160219
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30141436
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30141436
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29837325
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28715658
41	TCF4_23295773_ChIP-Seq_U87_Human	1.28069003
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25449736
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25244924
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24563254
45	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24163583
46	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.23711695
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.23360936
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22522717
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.20861624
50	STAT3_23295773_ChIP-Seq_U87_Human	1.20415025
51	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20071775
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.19154937
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19104828
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19063425
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19049236
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18119222
57	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17490067
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16858864
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16852466
60	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16728192
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.16619386
62	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.15490629
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15156417
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14979396
65	AR_20517297_ChIP-Seq_VCAP_Human	1.13612510
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13499718
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12316178
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12299777
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11821193
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11294525
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10165673
72	ERA_21632823_ChIP-Seq_H3396_Human	1.09645948
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08795998
74	JUN_21703547_ChIP-Seq_K562_Human	1.08309018
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08151983
76	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08100950
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07891075
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07891075
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06138821
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05478078
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05096184
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04943412
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02687906
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.00161877
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99895238
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99895238
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98175852
88	CDX2_22108803_ChIP-Seq_LS180_Human	0.98082651
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96799490
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96795605
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96353099
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96333251
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96272361
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95780027
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.94189305
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93924476
97	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.93263387
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.92981170
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92794676
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91986734

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	4.52683820
2	MP0002138_abnormal_hepatobiliary_system	3.80892494
3	MP0002653_abnormal_ependyma_morphology	3.50113545
4	MP0002735_abnormal_chemical_nociception	3.49085976
5	MP0005670_abnormal_white_adipose	3.39949122
6	MP0001984_abnormal_olfaction	3.12000837
7	MP0003183_abnormal_peptide_metabolism	3.05001725
8	MP0001968_abnormal_touch/_nociception	2.63970242
9	MP0002139_abnormal_hepatobiliary_system	2.62353190
10	MP0004133_heterotaxia	2.48272924
11	MP0008875_abnormal_xenobiotic_pharmacok	2.46561514
12	MP0000013_abnormal_adipose_tissue	2.43240721
13	MP0004742_abnormal_vestibular_system	2.41105771
14	MP0001486_abnormal_startle_reflex	2.28729193
15	MP0005410_abnormal_fertilization	2.23695182
16	MP0005645_abnormal_hypothalamus_physiol	1.97881809
17	MP0001440_abnormal_grooming_behavior	1.97562655
18	MP0009745_abnormal_behavioral_response	1.87261458
19	MP0001970_abnormal_pain_threshold	1.80317074
20	MP0004215_abnormal_myocardial_fiber	1.80272471
21	MP0005379_endocrine/exocrine_gland_phen	1.79918119
22	MP0002736_abnormal_nociception_after	1.79011084
23	MP0000537_abnormal_urethra_morphology	1.78568389
24	MP0001485_abnormal_pinna_reflex	1.78418533
25	MP0005551_abnormal_eye_electrophysiolog	1.73150447
26	MP0002734_abnormal_mechanical_nocicepti	1.64110885
27	MP0002064_seizures	1.63007831
28	MP0002572_abnormal_emotion/affect_behav	1.53364745
29	MP0005084_abnormal_gallbladder_morpholo	1.53099477
30	MP0002837_dystrophic_cardiac_calcinosis	1.49725142
31	MP0002557_abnormal_social/conspecific_i	1.44018925
32	MP0002733_abnormal_thermal_nociception	1.43934334
33	MP0003878_abnormal_ear_physiology	1.38250275
34	MP0005377_hearing/vestibular/ear_phenot	1.38250275
35	MP0000538_abnormal_urinary_bladder	1.35779940
36	MP0001905_abnormal_dopamine_level	1.35414895
37	MP0005423_abnormal_somatic_nervous	1.35051328
38	MP0008961_abnormal_basal_metabolism	1.34108246
39	MP0003195_calcinosis	1.30550552
40	MP0004885_abnormal_endolymph	1.30354155
41	MP0000230_abnormal_systemic_arterial	1.30042336
42	MP0002067_abnormal_sensory_capabilities	1.28912171
43	MP0002254_reproductive_system_inflammat	1.28729450
44	MP0002272_abnormal_nervous_system	1.28394511
45	MP0003880_abnormal_central_pattern	1.25913987
46	MP0008775_abnormal_heart_ventricle	1.20439313
47	MP0002876_abnormal_thyroid_physiology	1.18181178
48	MP0004147_increased_porphyrin_level	1.16402134
49	MP0001986_abnormal_taste_sensitivity	1.16135789
50	MP0008872_abnormal_physiological_respon	1.14893849
51	MP0003635_abnormal_synaptic_transmissio	1.12693439
52	MP0001756_abnormal_urination	1.12391950
53	MP0005167_abnormal_blood-brain_barrier	1.10443133
54	MP0006072_abnormal_retinal_apoptosis	1.10194564
55	MP0004043_abnormal_pH_regulation	1.09784227
56	MP0010329_abnormal_lipoprotein_level	1.09437327
57	MP0004145_abnormal_muscle_electrophysio	1.09333766
58	MP0004142_abnormal_muscle_tone	1.09328207
59	MP0001348_abnormal_lacrimal_gland	1.05970959
60	MP0006276_abnormal_autonomic_nervous	1.05012075
61	MP0004270_analgesia	1.04972952
62	MP0005332_abnormal_amino_acid	0.99276172
63	MP0005187_abnormal_penis_morphology	0.98932715
64	MP0005085_abnormal_gallbladder_physiolo	0.98219591
65	MP0001529_abnormal_vocalization	0.98008553
66	MP0008789_abnormal_olfactory_epithelium	0.97270343
67	MP0001919_abnormal_reproductive_system	0.93654902
68	MP0005636_abnormal_mineral_homeostasis	0.93518803
69	MP0003698_abnormal_male_reproductive	0.93096498
70	MP0002938_white_spotting	0.92851966
71	MP0001765_abnormal_ion_homeostasis	0.90120361
72	MP0005389_reproductive_system_phenotype	0.89608803
73	MP0005253_abnormal_eye_physiology	0.88983306
74	MP0002928_abnormal_bile_duct	0.88011441
75	MP0002160_abnormal_reproductive_system	0.87093412
76	MP0005365_abnormal_bile_salt	0.86681100
77	MP0002069_abnormal_eating/drinking_beha	0.86476851
78	MP0000613_abnormal_salivary_gland	0.83808274
79	MP0000955_abnormal_spinal_cord	0.83600899
80	MP0005595_abnormal_vascular_smooth	0.83574662
81	MP0002063_abnormal_learning/memory/cond	0.82871215
82	MP0009046_muscle_twitch	0.82225704
83	MP0004036_abnormal_muscle_relaxation	0.81616962
84	MP0002229_neurodegeneration	0.80645619
85	MP0002693_abnormal_pancreas_physiology	0.79860012
86	MP0004084_abnormal_cardiac_muscle	0.79790011
87	MP0002184_abnormal_innervation	0.79438554
88	MP0001929_abnormal_gametogenesis	0.76968650
89	MP0002752_abnormal_somatic_nervous	0.76495371
90	MP0002269_muscular_atrophy	0.75778537
91	MP0009643_abnormal_urine_homeostasis	0.75133413
92	MP0005448_abnormal_energy_balance	0.75015205
93	MP0000026_abnormal_inner_ear	0.74966370
94	MP0004085_abnormal_heartbeat	0.74955781
95	MP0001879_abnormal_lymphatic_vessel	0.73892105
96	MP0005195_abnormal_posterior_eye	0.73443582
97	MP0003718_maternal_effect	0.71070917
98	MP0002089_abnormal_postnatal_growth/wei	0.70916122
99	MP0003959_abnormal_lean_body	0.70561389
100	MP0005360_urolithiasis	0.69819093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar claw (HP:0001178)	5.46882625
2	Congenital sensorineural hearing impairment (HP:0008527)	4.23666846
3	Pancreatic cysts (HP:0001737)	3.70403041
4	Nephronophthisis (HP:0000090)	3.65403038
5	Medial flaring of the eyebrow (HP:0010747)	3.60684680
6	True hermaphroditism (HP:0010459)	3.53802351
7	Abnormality of midbrain morphology (HP:0002418)	3.53145759
8	Molar tooth sign on MRI (HP:0002419)	3.53145759
9	Decreased circulating renin level (HP:0003351)	3.49324674
10	Pancreatic fibrosis (HP:0100732)	3.42119329
11	Attenuation of retinal blood vessels (HP:0007843)	3.41248563
12	Abolished electroretinogram (ERG) (HP:0000550)	3.31697858
13	Large for gestational age (HP:0001520)	3.29807470
14	Constricted visual fields (HP:0001133)	3.17213245
15	Abnormality of the renal medulla (HP:0100957)	3.06867418
16	Spastic tetraparesis (HP:0001285)	3.06494486
17	Abnormal ciliary motility (HP:0012262)	3.01944270
18	Bony spicule pigmentary retinopathy (HP:0007737)	2.99469034
19	Gait imbalance (HP:0002141)	2.92294941
20	Genital tract atresia (HP:0001827)	2.91794030
21	Hyperglycinemia (HP:0002154)	2.88213777
22	Nephrogenic diabetes insipidus (HP:0009806)	2.82961119
23	Methylmalonic acidemia (HP:0002912)	2.77968589
24	Congenital primary aphakia (HP:0007707)	2.75011380
25	Abnormality of the vocal cords (HP:0008777)	2.74604756
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72143112
27	Absent/shortened dynein arms (HP:0200106)	2.72143112
28	Abnormality of macular pigmentation (HP:0008002)	2.67796751
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.67074289
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.67074289
31	Vaginal atresia (HP:0000148)	2.59701223
32	Abnormal biliary tract physiology (HP:0012439)	2.59086103
33	Bile duct proliferation (HP:0001408)	2.59086103
34	Acute encephalopathy (HP:0006846)	2.54076279
35	Late onset (HP:0003584)	2.52884897
36	Tongue fasciculations (HP:0001308)	2.49958485
37	Delayed CNS myelination (HP:0002188)	2.46063426
38	Acute necrotizing encephalopathy (HP:0006965)	2.46000661
39	Methylmalonic aciduria (HP:0012120)	2.42776875
40	Segmental peripheral demyelination/remyelination (HP:0003481)	2.34264326
41	Abnormal drinking behavior (HP:0030082)	2.33089032
42	Polydipsia (HP:0001959)	2.33089032
43	Generalized aminoaciduria (HP:0002909)	2.32664270
44	Retinal dysplasia (HP:0007973)	2.29788902
45	Congenital hepatic fibrosis (HP:0002612)	2.29787612
46	Chronic hepatic failure (HP:0100626)	2.28569381
47	Inability to walk (HP:0002540)	2.27073892
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.25203001
49	Furrowed tongue (HP:0000221)	2.20002815
50	Tubular atrophy (HP:0000092)	2.18211818
51	Hepatic necrosis (HP:0002605)	2.17414967
52	Ketoacidosis (HP:0001993)	2.16354797
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13379242
54	Abnormality of renin-angiotensin system (HP:0000847)	2.13294849
55	Mesangial abnormality (HP:0001966)	2.12983571
56	Occipital encephalocele (HP:0002085)	2.12645581
57	Anophthalmia (HP:0000528)	2.10650038
58	Amelogenesis imperfecta (HP:0000705)	2.09800546
59	Abnormality of serine family amino acid metabolism (HP:0010894)	2.08608904
60	Abnormality of glycine metabolism (HP:0010895)	2.08608904
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.08162266
62	Poikiloderma (HP:0001029)	2.07715809
63	Congenital stationary night blindness (HP:0007642)	2.06660844
64	Muscle fibrillation (HP:0010546)	2.04656060
65	Cerebral hemorrhage (HP:0001342)	2.02487874
66	Duplicated collecting system (HP:0000081)	2.00860108
67	Abnormality of the renal cortex (HP:0011035)	2.00858789
68	Pendular nystagmus (HP:0012043)	1.99972268
69	Mitochondrial inheritance (HP:0001427)	1.99756464
70	Progressive macrocephaly (HP:0004481)	1.99350179
71	Lissencephaly (HP:0001339)	1.99150581
72	Xanthomatosis (HP:0000991)	1.99081144
73	Cystic liver disease (HP:0006706)	1.98134001
74	Abnormality of the renal collecting system (HP:0004742)	1.97319820
75	Pachygyria (HP:0001302)	1.97076056
76	Progressive inability to walk (HP:0002505)	1.94930633
77	Congenital malformation of the right heart (HP:0011723)	1.94810019
78	Double outlet right ventricle (HP:0001719)	1.94810019
79	Hepatocellular necrosis (HP:0001404)	1.94779537
80	Global brain atrophy (HP:0002283)	1.94093577
81	Bilateral microphthalmos (HP:0007633)	1.93778806
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93431814
83	Hyperglycinuria (HP:0003108)	1.92555814
84	Male pseudohermaphroditism (HP:0000037)	1.89608667
85	Hyperaldosteronism (HP:0000859)	1.88283415
86	Intestinal atresia (HP:0011100)	1.87626811
87	Ketosis (HP:0001946)	1.87271605
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.85803358
89	Retinal atrophy (HP:0001105)	1.85287696
90	Chorioretinal atrophy (HP:0000533)	1.85012560
91	Oligodactyly (hands) (HP:0001180)	1.84660188
92	Poor coordination (HP:0002370)	1.84392752
93	Hypothermia (HP:0002045)	1.84297552
94	Syncope (HP:0001279)	1.82475736
95	Cerebral edema (HP:0002181)	1.81882898
96	Hyperactive renin-angiotensin system (HP:0000841)	1.81199590
97	Stomatitis (HP:0010280)	1.81082025
98	Increased CSF lactate (HP:0002490)	1.80442734
99	Hypoplasia of the brainstem (HP:0002365)	1.80003920
100	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.80003920

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.56893452
2	WNK3	3.90912809
3	FRK	3.82247060
4	CDK8	3.10903949
5	ZAK	2.91921504
6	MAP3K12	2.77680885
7	TLK1	2.73771082
8	TGFBR1	2.67796866
9	PINK1	2.65331705
10	WNK4	2.19541475
11	MST4	2.17364787
12	ADRBK2	1.77941677
13	STK38	1.76671044
14	MARK1	1.72512622
15	BLK	1.72325465
16	GRK1	1.71385952
17	MAPK13	1.68989165
18	PTK2B	1.67500582
19	MAP3K4	1.66446834
20	VRK1	1.51976090
21	BUB1	1.47275794
22	DAPK2	1.46574597
23	MAPKAPK3	1.39875876
24	INSRR	1.39193017
25	MAP2K7	1.38926684
26	OXSR1	1.37618241
27	PHKG1	1.36580221
28	PHKG2	1.36580221
29	PIK3CG	1.33023210
30	MAP2K6	1.27794192
31	DYRK2	1.27049523
32	STK38L	1.23446053
33	TAOK1	1.22105960
34	TXK	1.18491920
35	FER	1.18154761
36	CDK9	1.17768028
37	TAF1	1.15665045
38	STK16	1.14021687
39	LIMK1	1.11534692
40	PIK3CA	1.08900616
41	IRAK1	1.05571680
42	PRKCE	1.04972549
43	STK39	1.03703475
44	CSNK1G2	1.03139471
45	CSNK1G3	1.02756836
46	ADRBK1	1.01631903
47	TEC	1.00805020
48	BCR	0.98126192
49	TESK1	0.97281561
50	PLK2	0.87992832
51	MYLK	0.87047916
52	CSNK1G1	0.83805989
53	DAPK3	0.78700774
54	PRKCG	0.78381782
55	CDK3	0.76508933
56	MAP4K2	0.75966857
57	PIM2	0.75643208
58	RPS6KA5	0.74941129
59	CSNK1A1L	0.72190317
60	PAK3	0.69858525
61	MINK1	0.68917145
62	UHMK1	0.67644023
63	EPHB1	0.65585357
64	VRK2	0.64209341
65	DAPK1	0.64132160
66	DYRK1B	0.58787079
67	CAMK2A	0.58267305
68	PLK4	0.58005173
69	PRKACA	0.55796056
70	PKN1	0.54892984
71	CSF1R	0.54573065
72	GRK7	0.52164892
73	PRKG1	0.52009926
74	NTRK3	0.49669197
75	CSNK1A1	0.48663178
76	PRKCA	0.47986920
77	ITK	0.46926231
78	NUAK1	0.41754602
79	PNCK	0.41038987
80	OBSCN	0.40869832
81	CAMK2G	0.39838907
82	CHEK2	0.39156808
83	FGFR4	0.38582640
84	PRKG2	0.38336098
85	MAPK12	0.38066293
86	EPHA4	0.37245607
87	PRKCZ	0.36908515
88	PRKCB	0.35944662
89	TRPM7	0.34317066
90	PRKACG	0.33046863
91	FES	0.32803872
92	WNK1	0.32251239
93	BMPR2	0.31095395
94	PRKCQ	0.29833717
95	TRIM28	0.29062289
96	CAMKK2	0.27363849
97	TAOK3	0.27073614
98	CDK7	0.26980452
99	CAMK2B	0.26789655
100	PRKACB	0.25746755

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	2.86209386
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.71691600
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63124162
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61437157
5	Nicotine addiction_Homo sapiens_hsa05033	2.57552549
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.55227095
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.50417874
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.46309709
9	Parkinsons disease_Homo sapiens_hsa05012	2.27975802
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18426748
11	Fat digestion and absorption_Homo sapiens_hsa04975	2.11749083
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.09837691
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.08449392
14	Butanoate metabolism_Homo sapiens_hsa00650	2.02112170
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.99325293
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98951113
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.95157204
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.94887204
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.92991104
20	Taste transduction_Homo sapiens_hsa04742	1.70076031
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.60887548
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59842906
23	Alzheimers disease_Homo sapiens_hsa05010	1.52852523
24	Serotonergic synapse_Homo sapiens_hsa04726	1.40492232
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.37537283
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.36305735
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35997178
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.35081574
29	Huntingtons disease_Homo sapiens_hsa05016	1.32485070
30	Phototransduction_Homo sapiens_hsa04744	1.24716672
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22973652
32	Pancreatic secretion_Homo sapiens_hsa04972	1.20025598
33	Pentose phosphate pathway_Homo sapiens_hsa00030	1.18045076
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15599515
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14449474
36	Glutathione metabolism_Homo sapiens_hsa00480	1.13619869
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12562057
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11603596
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.09947377
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.08634049
41	Morphine addiction_Homo sapiens_hsa05032	1.08287850
42	Olfactory transduction_Homo sapiens_hsa04740	1.07975412
43	Salivary secretion_Homo sapiens_hsa04970	1.07859511
44	Circadian entrainment_Homo sapiens_hsa04713	0.99542056
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99072947
46	Sulfur metabolism_Homo sapiens_hsa00920	0.97433253
47	Proteasome_Homo sapiens_hsa03050	0.96726127
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.96725386
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.96053297
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.95345421
51	Peroxisome_Homo sapiens_hsa04146	0.92836111
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.91475918
53	GABAergic synapse_Homo sapiens_hsa04727	0.90592077
54	Fatty acid elongation_Homo sapiens_hsa00062	0.89607662
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.88938051
56	Basal transcription factors_Homo sapiens_hsa03022	0.88611135
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88197340
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87839554
59	Caffeine metabolism_Homo sapiens_hsa00232	0.83099702
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.83061517
61	One carbon pool by folate_Homo sapiens_hsa00670	0.81688176
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80035992
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78674588
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76651579
65	Metabolic pathways_Homo sapiens_hsa01100	0.73120411
66	Regulation of autophagy_Homo sapiens_hsa04140	0.72046303
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71525930
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70295203
69	RNA polymerase_Homo sapiens_hsa03020	0.69993319
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66787842
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66637153
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65033683
73	Insulin secretion_Homo sapiens_hsa04911	0.63944525
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.63164678
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62942075
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62851462
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.62347617
78	Amphetamine addiction_Homo sapiens_hsa05031	0.61389109
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60700972
80	Histidine metabolism_Homo sapiens_hsa00340	0.59138427
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57611369
82	Renin secretion_Homo sapiens_hsa04924	0.54789709
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.53779642
84	Cocaine addiction_Homo sapiens_hsa05030	0.53522659
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.50439226
86	Gastric acid secretion_Homo sapiens_hsa04971	0.49934987
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46894398
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46831538
89	Propanoate metabolism_Homo sapiens_hsa00640	0.43494426
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.42877504
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40285392
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39913132
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39611208
94	Asthma_Homo sapiens_hsa05310	0.36045545
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35691051
96	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.35291389
97	Platelet activation_Homo sapiens_hsa04611	0.35170483
98	Alcoholism_Homo sapiens_hsa05034	0.34969683
99	ABC transporters_Homo sapiens_hsa02010	0.34068168
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32231071

TNRC18P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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