TNRC18P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.57246543
2response to pheromone (GO:0019236)8.15639859
3acrosome reaction (GO:0007340)7.53326218
4rRNA methylation (GO:0031167)7.33374867
5positive regulation of action potential (GO:0045760)7.15375532
6sperm motility (GO:0030317)6.86345272
7rRNA modification (GO:0000154)6.20500319
8protein polyglutamylation (GO:0018095)6.15776650
9regulation of acrosome reaction (GO:0060046)5.81345845
10sperm-egg recognition (GO:0035036)5.56737375
11multicellular organism reproduction (GO:0032504)5.27633409
12regulation of cilium movement (GO:0003352)5.04744229
13RNA destabilization (GO:0050779)4.91663884
14centriole replication (GO:0007099)4.89426135
15calcium ion-dependent exocytosis (GO:0017156)4.75393821
16sperm capacitation (GO:0048240)4.67494974
17spermatid development (GO:0007286)4.66973006
18cell-cell recognition (GO:0009988)4.66611582
19binding of sperm to zona pellucida (GO:0007339)4.40634766
20spermatid nucleus differentiation (GO:0007289)4.40230181
21regulation of transcription involved in cell fate commitment (GO:0060850)4.26018631
22axonemal dynein complex assembly (GO:0070286)4.21890215
23reproduction (GO:0000003)4.21564219
24epithelial cilium movement (GO:0003351)4.20350412
25regulation of action potential (GO:0098900)4.14305655
26microtubule severing (GO:0051013)4.11507599
27polarized epithelial cell differentiation (GO:0030859)4.08948224
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.92776552
29cranial nerve morphogenesis (GO:0021602)3.91699387
30muscle organ morphogenesis (GO:0048644)3.91343434
31regulation of female gonad development (GO:2000194)3.89617004
32centriole assembly (GO:0098534)3.87976007
33microtubule depolymerization (GO:0007019)3.85375858
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.82702177
35DNA deamination (GO:0045006)3.79908151
36establishment of apical/basal cell polarity (GO:0035089)3.74772575
37kidney mesenchyme development (GO:0072074)3.72035630
38primary amino compound metabolic process (GO:1901160)3.69319248
39positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.57842522
40DNA packaging (GO:0006323)3.56920996
41NAD biosynthetic process (GO:0009435)3.56403174
42positive regulation of Rab GTPase activity (GO:0032851)3.54537564
43regulation of Rab GTPase activity (GO:0032313)3.54537564
44nerve growth factor signaling pathway (GO:0038180)3.53993822
45negative regulation of granulocyte differentiation (GO:0030853)3.47013096
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44967106
47regulation of cell communication by electrical coupling (GO:0010649)3.44169936
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.43596135
49establishment of monopolar cell polarity (GO:0061162)3.43596135
50chromosome condensation (GO:0030261)3.42109077
51neuronal action potential (GO:0019228)3.38651440
52seminiferous tubule development (GO:0072520)3.37010242
53peptidyl-threonine dephosphorylation (GO:0035970)3.34193649
54cilium or flagellum-dependent cell motility (GO:0001539)3.34052272
55microtubule polymerization or depolymerization (GO:0031109)3.33501473
56regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.24665320
57single fertilization (GO:0007338)3.19218813
58spermatogenesis (GO:0007283)3.16636253
59male gamete generation (GO:0048232)3.15603498
60serotonin metabolic process (GO:0042428)3.15424690
61regulation of microtubule-based movement (GO:0060632)3.13894146
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.13742330
63mast cell activation involved in immune response (GO:0002279)3.12372116
64mast cell degranulation (GO:0043303)3.12372116
65axoneme assembly (GO:0035082)3.11447281
66metanephric mesenchyme development (GO:0072075)3.11194632
67cilium movement (GO:0003341)3.09906097
68DNA methylation involved in gamete generation (GO:0043046)3.05663280
69phosphatidylethanolamine biosynthetic process (GO:0006646)3.03295883
70lateral ventricle development (GO:0021670)2.98220540
71negative regulation of neurotransmitter transport (GO:0051589)2.96935119
72gamete generation (GO:0007276)2.96533098
73behavioral response to nicotine (GO:0035095)2.94703011
74negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.94640246
75protein-cofactor linkage (GO:0018065)2.89615803
76cornea development in camera-type eye (GO:0061303)2.87325528
77establishment of epithelial cell polarity (GO:0090162)2.82302951
78negative regulation of inclusion body assembly (GO:0090084)2.79588418
79positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.79162286
80pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77860517
81positive regulation of gastrulation (GO:2000543)2.77517558
82fertilization (GO:0009566)2.73368327
83regulation of establishment of cell polarity (GO:2000114)2.72636461
84phosphatidylethanolamine metabolic process (GO:0046337)2.71902754
85left/right axis specification (GO:0070986)2.70830057
86indole-containing compound metabolic process (GO:0042430)2.70792365
87cellular process involved in reproduction in multicellular organism (GO:0022412)2.70298058
88organic cation transport (GO:0015695)2.68666133
89piRNA metabolic process (GO:0034587)2.68192051
90membrane depolarization during action potential (GO:0086010)2.65830516
91germ cell development (GO:0007281)2.64749066
92pyrimidine nucleotide catabolic process (GO:0006244)2.62494677
93cell wall macromolecule metabolic process (GO:0044036)2.61741280
94negative regulation of cell aging (GO:0090344)2.60515109
95Golgi to endosome transport (GO:0006895)2.60363850
96cellular ketone body metabolic process (GO:0046950)2.60194866
97nicotinamide nucleotide biosynthetic process (GO:0019359)2.59819882
98pyridine nucleotide biosynthetic process (GO:0019363)2.59819882
99negative regulation of neurotransmitter secretion (GO:0046929)2.58452036
100fusion of sperm to egg plasma membrane (GO:0007342)12.5247547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.40515071
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94029237
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16088308
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47498078
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45980210
6VDR_22108803_ChIP-Seq_LS180_Human2.45257007
7ZNF274_21170338_ChIP-Seq_K562_Hela2.43151558
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26012004
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23691507
10EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.19598631
11GBX2_23144817_ChIP-Seq_PC3_Human2.06510297
12TAF2_19829295_ChIP-Seq_ESCs_Human2.00735531
13EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.97394147
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.96448942
15RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.88641070
16FUS_26573619_Chip-Seq_HEK293_Human1.88339817
17BCL6_27268052_Chip-Seq_Bcells_Human1.79363789
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79328275
19NANOG_20526341_ChIP-Seq_ESCs_Human1.79025187
20ERA_21632823_ChIP-Seq_H3396_Human1.76895256
21ER_23166858_ChIP-Seq_MCF-7_Human1.75529026
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73507096
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73507096
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.69995775
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69531210
26CBP_20019798_ChIP-Seq_JUKART_Human1.68523568
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68523568
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66412274
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.57085761
30DROSHA_22980978_ChIP-Seq_HELA_Human1.56817733
31E2F1_20622854_ChIP-Seq_HELA_Human1.53837764
32OCT4_20526341_ChIP-Seq_ESCs_Human1.52328007
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52163340
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.50750178
35RAC3_21632823_ChIP-Seq_H3396_Human1.48260065
36SCL_19346495_ChIP-Seq_HPC-7_Human1.40643289
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.40535597
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.40111637
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.38218099
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36442773
41MYC_19829295_ChIP-Seq_ESCs_Human1.34356678
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32536047
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32517049
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32386618
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32231748
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31666314
47P68_20966046_ChIP-Seq_HELA_Human1.30519993
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28509427
49REST_21632747_ChIP-Seq_MESCs_Mouse1.26274322
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.26133455
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25257897
52ERG_20517297_ChIP-Seq_VCAP_Human1.24778190
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24347342
54IRF1_19129219_ChIP-ChIP_H3396_Human1.23932382
55CTCF_20526341_ChIP-Seq_ESCs_Human1.23853291
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23848202
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.23619959
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.23491898
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22926999
60P53_21459846_ChIP-Seq_SAOS-2_Human1.21049767
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20229366
62RNF2_27304074_Chip-Seq_NSC_Mouse1.19589671
63TAF15_26573619_Chip-Seq_HEK293_Human1.17358166
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.17045984
65CEBPB_22108803_ChIP-Seq_LS180_Human1.16830541
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15265218
67P300_19829295_ChIP-Seq_ESCs_Human1.14643716
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14123729
69PHF8_20622854_ChIP-Seq_HELA_Human1.12957276
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11210662
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.10373584
72AR_25329375_ChIP-Seq_VCAP_Human1.09563225
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09509187
74EWS_26573619_Chip-Seq_HEK293_Human1.09184421
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08355049
76BCOR_27268052_Chip-Seq_Bcells_Human1.08000075
77P300_27268052_Chip-Seq_Bcells_Human1.07976697
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07088136
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06453446
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05874422
81FOXH1_21741376_ChIP-Seq_ESCs_Human1.05171955
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04373303
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02230940
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00623489
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00623489
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98698086
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98174510
88SMC4_20622854_ChIP-Seq_HELA_Human0.97667825
89TCF4_23295773_ChIP-Seq_U87_Human0.96770632
90KLF4_19829295_ChIP-Seq_ESCs_Human0.96047065
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.95913308
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93700542
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.93700542
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93330248
95RUNX2_22187159_ChIP-Seq_PCA_Human0.93016905
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92801591
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92150225
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91872405
99SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89572471
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89502547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.32542274
2MP0003646_muscle_fatigue3.65113143
3MP0004133_heterotaxia3.30029075
4MP0005670_abnormal_white_adipose3.25632431
5MP0003698_abnormal_male_reproductive2.63537482
6MP0003878_abnormal_ear_physiology2.40165502
7MP0005377_hearing/vestibular/ear_phenot2.40165502
8MP0005423_abnormal_somatic_nervous2.27929166
9MP0001929_abnormal_gametogenesis2.26029800
10MP0009697_abnormal_copulation2.21815157
11MP0002138_abnormal_hepatobiliary_system2.10091767
12MP0001905_abnormal_dopamine_level1.96293081
13MP0000678_abnormal_parathyroid_gland1.92211829
14MP0002822_catalepsy1.91815761
15MP0003283_abnormal_digestive_organ1.87009953
16MP0002928_abnormal_bile_duct1.84534031
17MP0009379_abnormal_foot_pigmentation1.83402134
18MP0002277_abnormal_respiratory_mucosa1.80400190
19MP0006276_abnormal_autonomic_nervous1.75085434
20MP0001440_abnormal_grooming_behavior1.74503665
21MP0004270_analgesia1.62431776
22MP0003011_delayed_dark_adaptation1.58907902
23MP0003724_increased_susceptibility_to1.57593364
24MP0003121_genomic_imprinting1.56896583
25MP0003122_maternal_imprinting1.55840701
26MP0001348_abnormal_lacrimal_gland1.54286886
27MP0001873_stomach_inflammation1.45914932
28MP0002938_white_spotting1.43338755
29MP0002161_abnormal_fertility/fecundity1.42809490
30MP0001501_abnormal_sleep_pattern1.41602826
31MP0005085_abnormal_gallbladder_physiolo1.39360194
32MP0009745_abnormal_behavioral_response1.37260843
33MP0005084_abnormal_gallbladder_morpholo1.37038680
34MP0001968_abnormal_touch/_nociception1.36950783
35MP0001486_abnormal_startle_reflex1.32764912
36MP0001485_abnormal_pinna_reflex1.31580705
37MP0009278_abnormal_bone_marrow1.31350441
38MP0003718_maternal_effect1.29429417
39MP0002272_abnormal_nervous_system1.29038933
40MP0002736_abnormal_nociception_after1.28417263
41MP0002210_abnormal_sex_determination1.28165132
42MP0005167_abnormal_blood-brain_barrier1.26227407
43MP0000470_abnormal_stomach_morphology1.25484295
44MP0002733_abnormal_thermal_nociception1.25382919
45MP0005551_abnormal_eye_electrophysiolog1.24729492
46MP0002557_abnormal_social/conspecific_i1.23187398
47MP0000569_abnormal_digit_pigmentation1.22372833
48MP0005310_abnormal_salivary_gland1.21961220
49MP0002653_abnormal_ependyma_morphology1.15092826
50MP0002572_abnormal_emotion/affect_behav1.14640285
51MP0008961_abnormal_basal_metabolism1.14187022
52MP0002735_abnormal_chemical_nociception1.12436727
53MP0008875_abnormal_xenobiotic_pharmacok1.11062248
54MP0002734_abnormal_mechanical_nocicepti1.08269605
55MP0000653_abnormal_sex_gland1.06004721
56MP0001970_abnormal_pain_threshold1.05960296
57MP0002064_seizures1.04652342
58MP0002234_abnormal_pharynx_morphology1.03903598
59MP0003385_abnormal_body_wall1.02645356
60MP0003787_abnormal_imprinting1.01097787
61MP0001145_abnormal_male_reproductive1.00174808
62MP0002837_dystrophic_cardiac_calcinosis1.00072890
63MP0001835_abnormal_antigen_presentation0.99578556
64MP0000049_abnormal_middle_ear0.99042116
65MP0002067_abnormal_sensory_capabilities0.97680493
66MP0003137_abnormal_impulse_conducting0.95615396
67MP0003635_abnormal_synaptic_transmissio0.93262780
68MP0001963_abnormal_hearing_physiology0.93215068
69MP0003123_paternal_imprinting0.93165850
70MP0001765_abnormal_ion_homeostasis0.93037527
71MP0009764_decreased_sensitivity_to0.91633996
72MP0006292_abnormal_olfactory_placode0.90952101
73MP0004742_abnormal_vestibular_system0.90595645
74MP0005671_abnormal_response_to0.90071002
75MP0005645_abnormal_hypothalamus_physiol0.89906186
76MP0000013_abnormal_adipose_tissue0.86696204
77MP0002933_joint_inflammation0.86690081
78MP0005636_abnormal_mineral_homeostasis0.86654637
79MP0002282_abnormal_trachea_morphology0.85798478
80MP0000955_abnormal_spinal_cord0.85008561
81MP0004036_abnormal_muscle_relaxation0.84907525
82MP0004859_abnormal_synaptic_plasticity0.84511851
83MP0001188_hyperpigmentation0.80061096
84MP0002102_abnormal_ear_morphology0.79869403
85MP0003252_abnormal_bile_duct0.79362781
86MP0008877_abnormal_DNA_methylation0.79090277
87MP0009765_abnormal_xenobiotic_induced0.77643264
88MP0005464_abnormal_platelet_physiology0.77370119
89MP0002132_abnormal_respiratory_system0.77102433
90MP0000003_abnormal_adipose_tissue0.75937627
91MP0002229_neurodegeneration0.74323071
92MP0000372_irregular_coat_pigmentation0.73321656
93MP0002160_abnormal_reproductive_system0.73140903
94MP0003942_abnormal_urinary_system0.72693706
95MP0001529_abnormal_vocalization0.71979054
96MP0001919_abnormal_reproductive_system0.70398089
97MP0008789_abnormal_olfactory_epithelium0.70321083
98MP0001727_abnormal_embryo_implantation0.69276637
99MP0001984_abnormal_olfaction0.68490175
100MP0000681_abnormal_thyroid_gland0.67282734

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)4.81145387
2Enlarged epiphyses (HP:0010580)4.77772329
3Chronic hepatic failure (HP:0100626)4.03120506
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.02218328
5Absent/shortened dynein arms (HP:0200106)4.02218328
6Abnormal ciliary motility (HP:0012262)3.90688604
7Abnormality of the renal medulla (HP:0100957)3.82747101
8Abnormal respiratory epithelium morphology (HP:0012253)3.70615103
9Abnormal respiratory motile cilium morphology (HP:0005938)3.70615103
10Pancreatic fibrosis (HP:0100732)3.67205835
11Abnormality of macular pigmentation (HP:0008002)3.66540713
12Abnormality of midbrain morphology (HP:0002418)3.65822375
13Molar tooth sign on MRI (HP:0002419)3.65822375
14Attenuation of retinal blood vessels (HP:0007843)3.65239614
15Severe visual impairment (HP:0001141)3.45491407
16Abnormal respiratory motile cilium physiology (HP:0012261)3.05245746
17Pancreatic cysts (HP:0001737)3.03303819
18Abnormality of lateral ventricle (HP:0030047)3.01182879
19Abnormal spermatogenesis (HP:0008669)2.96605603
20Azoospermia (HP:0000027)2.88192119
21True hermaphroditism (HP:0010459)2.81621411
22Bony spicule pigmentary retinopathy (HP:0007737)2.75813779
23Abnormal rod and cone electroretinograms (HP:0008323)2.67529273
24Abnormality of the vertebral endplates (HP:0005106)2.55915216
25Hypoplastic ischia (HP:0003175)2.47875942
26Infertility (HP:0000789)2.45071728
27Aplasia/Hypoplasia of the earlobes (HP:0009906)2.43587735
28Decreased central vision (HP:0007663)2.38103159
29Sclerocornea (HP:0000647)2.36568146
30Panhypogammaglobulinemia (HP:0003139)2.32971762
31Hypoplasia of the thymus (HP:0000778)2.30724851
32Abnormal drinking behavior (HP:0030082)2.28787239
33Polydipsia (HP:0001959)2.28787239
34Retinal dysplasia (HP:0007973)2.28416542
35Anterior segment dysgenesis (HP:0007700)2.16811354
36Cystic liver disease (HP:0006706)2.15752591
37Conjunctival telangiectasia (HP:0000524)2.14279127
38Abolished electroretinogram (ERG) (HP:0000550)2.12223449
39Renal Fanconi syndrome (HP:0001994)2.12094684
40Medial flaring of the eyebrow (HP:0010747)2.09986567
41Abnormality of renal resorption (HP:0011038)2.09031286
42Intellectual disability, moderate (HP:0002342)2.08566809
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08091638
44Abnormality of alanine metabolism (HP:0010916)2.08091638
45Hyperalaninemia (HP:0003348)2.08091638
46Hyperthyroidism (HP:0000836)2.07920655
47Long nose (HP:0003189)2.07127124
48Abnormality of the ischium (HP:0003174)2.05673693
49Furrowed tongue (HP:0000221)2.04592824
50Facial shape deformation (HP:0011334)2.01438251
51Potter facies (HP:0002009)2.01438251
52Portal hypertension (HP:0001409)2.00826257
53Chronic sinusitis (HP:0011109)2.00489093
54Abnormal urine output (HP:0012590)2.00355302
55Type II lissencephaly (HP:0007260)2.00101050
56Chronic mucocutaneous candidiasis (HP:0002728)1.99694872
57Recurrent cutaneous fungal infections (HP:0011370)1.99694872
58Abnormality of the hepatic vasculature (HP:0006707)1.94120744
59Congenital hepatic fibrosis (HP:0002612)1.94074912
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93744995
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93689646
62Congenital, generalized hypertrichosis (HP:0004540)1.92827107
63Large for gestational age (HP:0001520)1.92772983
64Polyuria (HP:0000103)1.91656329
65Acute necrotizing encephalopathy (HP:0006965)1.91471179
66Tubular atrophy (HP:0000092)1.89553499
67Bulbous nose (HP:0000414)1.89450533
68Postural instability (HP:0002172)1.87130009
69Renovascular hypertension (HP:0100817)1.86338261
70Abnormality of the epiphysis of the femoral head (HP:0010574)1.86140587
71Anencephaly (HP:0002323)1.85529859
72Male infertility (HP:0003251)1.85094950
73Progressive cerebellar ataxia (HP:0002073)1.84202378
74Occipital encephalocele (HP:0002085)1.81322390
75Confusion (HP:0001289)1.81165860
76IgG deficiency (HP:0004315)1.79501228
77Abnormal mitochondria in muscle tissue (HP:0008316)1.79032579
78Delayed epiphyseal ossification (HP:0002663)1.78511935
79Abnormality of the costochondral junction (HP:0000919)1.78361738
80Hypophosphatemic rickets (HP:0004912)1.76217757
81Abnormality of T cell physiology (HP:0011840)1.73909147
82Abnormality of the femoral head (HP:0003368)1.73369352
83Mitochondrial inheritance (HP:0001427)1.71472875
84Abnormality of renal excretion (HP:0011036)1.71123764
85Flattened epiphyses (HP:0003071)1.70864093
86Asymmetric septal hypertrophy (HP:0001670)1.69873915
87Resting tremor (HP:0002322)1.68210360
88Recurrent fungal infections (HP:0002841)1.67494289
89Increased CSF lactate (HP:0002490)1.66853787
90Muscle fiber atrophy (HP:0100295)1.65489195
91Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.64524732
92Abnormality of femoral epiphyses (HP:0006499)1.64524732
93Agammaglobulinemia (HP:0004432)1.64274183
94Type 2 muscle fiber atrophy (HP:0003554)1.63606369
95Nasal polyposis (HP:0100582)1.63396509
96Type I diabetes mellitus (HP:0100651)1.62148626
97Elevated erythrocyte sedimentation rate (HP:0003565)1.60911447
98Opisthotonus (HP:0002179)1.60640522
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.59489381
100Male pseudohermaphroditism (HP:0000037)1.59405137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.17458992
2SIK24.16373563
3PLK43.72259380
4TESK13.45647040
5BCKDK3.00902343
6NTRK12.78700922
7PRKD32.72842472
8TAF12.71482553
9CDC72.64946746
10PNCK2.55580006
11PLK22.38002305
12DDR22.36591279
13ZAK2.36055136
14TGFBR12.26338169
15CDK82.13939050
16INSRR2.02062614
17FRK1.76854590
18STK381.76290236
19PASK1.61962720
20KIT1.61424928
21PTK2B1.54504427
22WNK41.54426516
23MAP4K21.53541752
24TAOK31.53294076
25MAPKAPK31.50589027
26NUAK11.46130589
27GRK11.39420178
28PINK11.32748390
29SIK31.31653469
30PIK3CG1.27987921
31MAP2K21.26863070
32MAPK151.26755487
33CDK71.21268726
34TLK11.20423312
35KDR1.11647285
36WNK11.03137468
37TESK20.99878041
38PRKG20.98338446
39ADRBK20.96741746
40MAPK130.91902840
41CAMK1G0.89442324
42MAP4K10.88606295
43DYRK20.85186356
44TRIM280.80279544
45NTRK30.80159354
46STK390.78776272
47JAK30.72024401
48CDK190.66924355
49CDK90.64438535
50NTRK20.64364344
51SYK0.61423110
52RPS6KA40.60394008
53RPS6KA60.59540123
54MATK0.59038860
55BUB10.54097100
56PIM20.53751753
57GRK70.50316356
58RPS6KA20.49771955
59PRKD20.48315539
60MAP3K110.47807730
61CAMK10.47493276
62TXK0.45851560
63PRKG10.45068459
64PRKCH0.44600984
65CDK30.44432113
66LIMK10.44012224
67RPS6KC10.42941704
68RPS6KL10.42941704
69CCNB10.42187313
70PRKCE0.41878411
71TNK20.41685507
72PDK10.37939278
73NEK20.37821918
74ADRBK10.36549614
75PRKCZ0.35253205
76ABL20.34220058
77MAP2K70.34141242
78RPS6KB20.33810425
79DYRK30.33593848
80ATR0.32165308
81PRKCQ0.31735368
82MAPK110.30203109
83BCR0.29997339
84EEF2K0.29113301
85RPS6KA50.29090015
86PLK10.28782904
87MAPK120.26964094
88TEC0.26615640
89MARK30.26414864
90RAF10.26343486
91FLT30.26225118
92MAPKAPK50.25484285
93CDK20.25037466
94PRKACA0.24230836
95DYRK1B0.24157340
96CAMK2A0.24027423
97ILK0.23352012
98CSNK1G30.22444266
99DAPK10.22269298
100PRKCA0.21971014

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.81222095
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.57205786
3Olfactory transduction_Homo sapiens_hsa047402.42722197
4Fatty acid biosynthesis_Homo sapiens_hsa000612.29486407
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17552563
6Fatty acid degradation_Homo sapiens_hsa000712.15431105
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.08570969
8Taste transduction_Homo sapiens_hsa047421.95599336
9Nicotine addiction_Homo sapiens_hsa050331.95413852
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84167503
11Basal transcription factors_Homo sapiens_hsa030221.83304683
12Oxidative phosphorylation_Homo sapiens_hsa001901.81881682
13Asthma_Homo sapiens_hsa053101.81694804
14Allograft rejection_Homo sapiens_hsa053301.79770263
15Primary immunodeficiency_Homo sapiens_hsa053401.78782496
16Parkinsons disease_Homo sapiens_hsa050121.77907478
17Base excision repair_Homo sapiens_hsa034101.76975166
18Tryptophan metabolism_Homo sapiens_hsa003801.74170034
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69504133
20DNA replication_Homo sapiens_hsa030301.67975084
21Huntingtons disease_Homo sapiens_hsa050161.66419294
22Autoimmune thyroid disease_Homo sapiens_hsa053201.62435213
23Linoleic acid metabolism_Homo sapiens_hsa005911.62262170
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58515271
25Sulfur relay system_Homo sapiens_hsa041221.56609387
26Fatty acid metabolism_Homo sapiens_hsa012121.54873000
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44588535
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.43048286
29Cardiac muscle contraction_Homo sapiens_hsa042601.41176511
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38569743
31Morphine addiction_Homo sapiens_hsa050321.34540579
32ABC transporters_Homo sapiens_hsa020101.31474452
33Graft-versus-host disease_Homo sapiens_hsa053321.28858776
34Salivary secretion_Homo sapiens_hsa049701.27807528
35Calcium signaling pathway_Homo sapiens_hsa040201.23749605
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.23362085
37Type I diabetes mellitus_Homo sapiens_hsa049401.21753932
38Alzheimers disease_Homo sapiens_hsa050101.21661725
39Circadian entrainment_Homo sapiens_hsa047131.19692695
40Gastric acid secretion_Homo sapiens_hsa049711.15989308
41Ribosome_Homo sapiens_hsa030101.15249097
42Non-homologous end-joining_Homo sapiens_hsa034501.13002253
43Phototransduction_Homo sapiens_hsa047441.08115678
44Renin secretion_Homo sapiens_hsa049241.07825830
45Peroxisome_Homo sapiens_hsa041461.03276921
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03176827
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99479758
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.94466038
49Homologous recombination_Homo sapiens_hsa034400.94007603
50Fanconi anemia pathway_Homo sapiens_hsa034600.93814060
51Sulfur metabolism_Homo sapiens_hsa009200.93774277
52Fat digestion and absorption_Homo sapiens_hsa049750.90324119
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90148439
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88699497
55Purine metabolism_Homo sapiens_hsa002300.86737721
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.85362631
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84622818
58Vitamin B6 metabolism_Homo sapiens_hsa007500.84108522
59Glutamatergic synapse_Homo sapiens_hsa047240.83756518
60Nucleotide excision repair_Homo sapiens_hsa034200.82083108
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80634921
62Antigen processing and presentation_Homo sapiens_hsa046120.79181775
63Serotonergic synapse_Homo sapiens_hsa047260.78792843
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78274988
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.77292158
66Pyrimidine metabolism_Homo sapiens_hsa002400.77221430
67Nitrogen metabolism_Homo sapiens_hsa009100.76088480
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75171772
69Insulin secretion_Homo sapiens_hsa049110.71915736
70Pancreatic secretion_Homo sapiens_hsa049720.70657084
71RNA degradation_Homo sapiens_hsa030180.70033746
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68598795
73Hedgehog signaling pathway_Homo sapiens_hsa043400.67653857
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67653423
75Type II diabetes mellitus_Homo sapiens_hsa049300.67068227
76Viral myocarditis_Homo sapiens_hsa054160.66679824
77One carbon pool by folate_Homo sapiens_hsa006700.65965776
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64102720
79Platelet activation_Homo sapiens_hsa046110.63979045
80Amphetamine addiction_Homo sapiens_hsa050310.62823091
81Retinol metabolism_Homo sapiens_hsa008300.61616877
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61188996
83Regulation of autophagy_Homo sapiens_hsa041400.60778906
84Ether lipid metabolism_Homo sapiens_hsa005650.59892536
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59697321
86Butanoate metabolism_Homo sapiens_hsa006500.59279618
87PPAR signaling pathway_Homo sapiens_hsa033200.59225867
88RNA polymerase_Homo sapiens_hsa030200.56886916
89Glycerolipid metabolism_Homo sapiens_hsa005610.56005333
90Cocaine addiction_Homo sapiens_hsa050300.55795336
91Oxytocin signaling pathway_Homo sapiens_hsa049210.54479810
92Metabolic pathways_Homo sapiens_hsa011000.53511309
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50722720
94GABAergic synapse_Homo sapiens_hsa047270.50262576
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47084971
96RNA transport_Homo sapiens_hsa030130.45168801
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42970060
98Tyrosine metabolism_Homo sapiens_hsa003500.42959790
99Long-term potentiation_Homo sapiens_hsa047200.42345120
100cAMP signaling pathway_Homo sapiens_hsa040240.42111584

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