TNRC6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.01067719
2negative regulation of cell killing (GO:0031342)6.01067719
3histone H3-K4 trimethylation (GO:0080182)5.48583965
4cytoplasmic mRNA processing body assembly (GO:0033962)4.49044027
5regulation of posttranscriptional gene silencing (GO:0060147)4.33342067
6regulation of gene silencing by miRNA (GO:0060964)4.33342067
7regulation of gene silencing by RNA (GO:0060966)4.33342067
8histone H3-K4 methylation (GO:0051568)4.26818277
9peptidyl-lysine trimethylation (GO:0018023)4.07590803
10pre-miRNA processing (GO:0031054)3.93122347
11cerebellar Purkinje cell differentiation (GO:0021702)3.64013355
12positive thymic T cell selection (GO:0045059)3.51600511
13paraxial mesoderm development (GO:0048339)3.49987188
14histone lysine methylation (GO:0034968)3.40058955
15positive regulation of gamma-delta T cell activation (GO:0046645)3.28364434
16nuclear pore complex assembly (GO:0051292)3.27444321
17presynaptic membrane assembly (GO:0097105)3.22415451
18peptidyl-lysine methylation (GO:0018022)3.20101060
19positive T cell selection (GO:0043368)3.15567516
20positive regulation of histone deacetylation (GO:0031065)3.09579807
21regulation of gamma-delta T cell differentiation (GO:0045586)3.05205818
22establishment of protein localization to Golgi (GO:0072600)3.05201454
23insulin-like growth factor receptor signaling pathway (GO:0048009)3.03139269
24histone H3-K36 demethylation (GO:0070544)2.99381382
25embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98849137
26protein targeting to Golgi (GO:0000042)2.98810655
27nuclear pore organization (GO:0006999)2.90265565
28retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89405876
29presynaptic membrane organization (GO:0097090)2.87654326
30regulation of DNA methylation (GO:0044030)2.86028932
31stress granule assembly (GO:0034063)2.84783756
32negative T cell selection (GO:0043383)2.81818673
33negative thymic T cell selection (GO:0045060)2.78501639
34heterochromatin organization (GO:0070828)2.78493625
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77850036
36mRNA splice site selection (GO:0006376)2.77619695
37head development (GO:0060322)2.74492242
38mitotic sister chromatid cohesion (GO:0007064)2.73471439
39positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69925410
40regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69925410
41regulation of gamma-delta T cell activation (GO:0046643)2.69505312
42sodium ion export (GO:0071436)2.68946773
43regulation of ARF protein signal transduction (GO:0032012)2.66911733
44* negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64504205
45* negative regulation of translation, ncRNA-mediated (GO:0040033)2.64504205
46* regulation of translation, ncRNA-mediated (GO:0045974)2.64504205
47peptidyl-lysine dimethylation (GO:0018027)2.59610543
48artery development (GO:0060840)2.58483725
49thymic T cell selection (GO:0045061)2.58112926
50regulation of histone H3-K9 methylation (GO:0051570)2.57549922
51positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.57034228
52regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.57034228
53histone methylation (GO:0016571)2.56671542
54anterior/posterior axis specification, embryo (GO:0008595)2.55243649
55histone H3-K9 modification (GO:0061647)2.53267344
56postsynaptic membrane organization (GO:0001941)2.52323830
57body morphogenesis (GO:0010171)2.52308750
58camera-type eye morphogenesis (GO:0048593)2.52176586
59notochord development (GO:0030903)2.51245996
60inner ear receptor cell development (GO:0060119)2.51218354
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50424999
62regulation of non-canonical Wnt signaling pathway (GO:2000050)2.49894154
63dorsal/ventral axis specification (GO:0009950)2.49579026
64dendrite morphogenesis (GO:0048813)2.49082093
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.46380133
66histone H4-K16 acetylation (GO:0043984)2.46341421
67establishment of nucleus localization (GO:0040023)2.45362432
68kidney morphogenesis (GO:0060993)2.44246535
69locomotory exploration behavior (GO:0035641)2.44195111
70regulation of RNA export from nucleus (GO:0046831)2.44189196
71positive regulation of RNA splicing (GO:0033120)2.43093708
72cell migration in hindbrain (GO:0021535)2.42487604
73cell differentiation in hindbrain (GO:0021533)2.41680862
74regulation of histone H3-K4 methylation (GO:0051569)2.41469259
75regulation of hippo signaling (GO:0035330)2.40812119
76interkinetic nuclear migration (GO:0022027)2.40298181
77histone H3-K9 methylation (GO:0051567)2.39994532
78vocalization behavior (GO:0071625)2.39276444
79T cell selection (GO:0045058)2.38787818
80histone H3-K9 demethylation (GO:0033169)2.38478403
81generation of neurons (GO:0048699)2.32852706
82lung-associated mesenchyme development (GO:0060484)2.31616917
83convergent extension (GO:0060026)2.31150277
84heart morphogenesis (GO:0003007)2.29866837
85negative regulation of histone methylation (GO:0031061)2.28339803
86embryonic foregut morphogenesis (GO:0048617)2.28133998
87embryonic body morphogenesis (GO:0010172)2.27425740
88DNA damage induced protein phosphorylation (GO:0006975)2.25601879
89spinal cord development (GO:0021510)2.24828124
90regulation of nucleobase-containing compound transport (GO:0032239)2.23775518
91regulation of DNA endoreduplication (GO:0032875)2.23632683
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23586402
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23528637
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.22326079
95cellular potassium ion homeostasis (GO:0030007)2.22157804
96histone lysine demethylation (GO:0070076)2.22046849
97glucocorticoid receptor signaling pathway (GO:0042921)2.21933256
98regulation of telomere maintenance via telomerase (GO:0032210)2.21083591
99cortical actin cytoskeleton organization (GO:0030866)2.20301379
100regulation of neuron migration (GO:2001222)2.20227408
101nodal signaling pathway (GO:0038092)2.19798475
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.19697945
103potassium ion import (GO:0010107)2.19597866
104regulation of protein polyubiquitination (GO:1902914)2.19074888
105negative regulation of T cell mediated immunity (GO:0002710)2.19033001
106urinary tract smooth muscle contraction (GO:0014848)2.18997815
107regulation of histone deacetylation (GO:0031063)2.18871341
108regulation of gene silencing (GO:0060968)2.18376714
109regulation of telomere maintenance (GO:0032204)2.18374750
110neuron recognition (GO:0008038)2.18316168
111layer formation in cerebral cortex (GO:0021819)2.17584555
112L-amino acid import (GO:0043092)2.16408781
113prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.15724055
114regulation of mRNA catabolic process (GO:0061013)2.15022075
115regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14436296
116positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.14422647
117protein localization to kinetochore (GO:0034501)2.14195321
118nerve growth factor signaling pathway (GO:0038180)2.12756038
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.12435797
120phospholipid translocation (GO:0045332)2.12235466
121lipid translocation (GO:0034204)2.12235466
122negative regulation of DNA repair (GO:0045738)2.12226486
123monoubiquitinated protein deubiquitination (GO:0035520)2.12196104
124chromatin silencing (GO:0006342)2.11799267
125neural tube closure (GO:0001843)2.10689206
126positive regulation of SMAD protein import into nucleus (GO:0060391)2.10584012
127NLS-bearing protein import into nucleus (GO:0006607)2.10382314
128activated T cell proliferation (GO:0050798)2.10209380
129regulation of histone methylation (GO:0031060)2.09984174
130positive regulation of gene expression, epigenetic (GO:0045815)2.09110790
131regulation of isotype switching to IgG isotypes (GO:0048302)2.08865019
132tube closure (GO:0060606)2.08851108
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.08561204
134suckling behavior (GO:0001967)2.08233760
135synaptic vesicle maturation (GO:0016188)2.08134922
136nucleus localization (GO:0051647)2.08109029
137positive regulation of mRNA catabolic process (GO:0061014)2.07539660
138regulation of stem cell maintenance (GO:2000036)2.07049369
139response to interleukin-15 (GO:0070672)2.06122805
140positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.06045391
141positive regulation of cell cycle G2/M phase transition (GO:1902751)2.06045391
142atrial cardiac muscle cell action potential (GO:0086014)2.05867125
143neuronal stem cell maintenance (GO:0097150)2.05573480
144protein localization to synapse (GO:0035418)2.05442540
145phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.05088328
146forebrain neuron differentiation (GO:0021879)2.04815112
147lymphangiogenesis (GO:0001946)2.04571977
148positive regulation of catenin import into nucleus (GO:0035413)2.04078925
149histone demethylation (GO:0016577)2.03519032
150olfactory bulb development (GO:0021772)2.03097574
151neurotransmitter-gated ion channel clustering (GO:0072578)2.02579508
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.01218096
153regulation of NFAT protein import into nucleus (GO:0051532)2.00790788
154peripheral nervous system axon ensheathment (GO:0032292)2.00758952
155myelination in peripheral nervous system (GO:0022011)2.00758952
156asymmetric protein localization (GO:0008105)2.00659501
157mating behavior (GO:0007617)2.00309048
158limb development (GO:0060173)2.00190222
159appendage development (GO:0048736)2.00190222
160cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.00118987
161ectodermal placode formation (GO:0060788)2.00087138
162cell migration involved in sprouting angiogenesis (GO:0002042)1.99806112
163axonal fasciculation (GO:0007413)1.99382589
164regulation of intracellular estrogen receptor signaling pathway (GO:0033146)1.99344210
165regulation of ARF GTPase activity (GO:0032312)1.99018113
166regulation of histone H3-K27 methylation (GO:0061085)1.98978375
167regulation of axon extension involved in axon guidance (GO:0048841)1.98649109
168hippo signaling (GO:0035329)1.97944747
169regulation of clathrin-mediated endocytosis (GO:2000369)1.97651972
170DNA methylation (GO:0006306)1.97559856
171DNA alkylation (GO:0006305)1.97559856
172neural tube development (GO:0021915)1.97450541
173potassium ion homeostasis (GO:0055075)1.96454615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88897274
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51073474
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44985038
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44175959
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39697065
6DROSHA_22980978_ChIP-Seq_HELA_Human2.37181666
7E2F7_22180533_ChIP-Seq_HELA_Human2.32342992
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23528380
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13197834
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06554178
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.02469941
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.02372995
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96796456
14EZH2_22144423_ChIP-Seq_EOC_Human1.94743123
15FOXM1_23109430_ChIP-Seq_U2OS_Human1.94133241
16* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.80773636
17FUS_26573619_Chip-Seq_HEK293_Human1.77522176
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73967859
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70233298
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.69383631
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68505189
22AR_21572438_ChIP-Seq_LNCaP_Human1.68443106
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66662767
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63987975
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63448366
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62215575
27TP53_16413492_ChIP-PET_HCT116_Human1.61275072
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60221245
29GBX2_23144817_ChIP-Seq_PC3_Human1.58261891
30RUNX_20019798_ChIP-Seq_JUKART_Human1.58176935
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.57574260
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57534121
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57534121
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57534121
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56240614
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55723296
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54263836
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53178913
39STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.48623892
40KDM2B_26808549_Chip-Seq_DND41_Human1.48445437
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46411858
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46289755
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.45198485
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45095002
45AHR_22903824_ChIP-Seq_MCF-7_Human1.45049157
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43677668
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43129108
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41428737
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41428737
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.40787012
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40334610
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.39718479
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39269556
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39237534
55* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39198467
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38505093
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38468900
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.38059894
59TAF15_26573619_Chip-Seq_HEK293_Human1.37942505
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36672029
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36655059
62* RARB_27405468_Chip-Seq_BRAIN_Mouse1.36510478
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35978609
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34762427
65TCF7_22412390_ChIP-Seq_EML_Mouse1.33942086
66KDM2B_26808549_Chip-Seq_K562_Human1.33032849
67STAT3_23295773_ChIP-Seq_U87_Human1.32405863
68ZNF274_21170338_ChIP-Seq_K562_Hela1.31613155
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30759765
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30379688
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29896683
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29790658
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29352675
74* AR_19668381_ChIP-Seq_PC3_Human1.29185440
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29170862
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.28423805
77REST_21632747_ChIP-Seq_MESCs_Mouse1.26160470
78EWS_26573619_Chip-Seq_HEK293_Human1.25717809
79* P300_19829295_ChIP-Seq_ESCs_Human1.25057616
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25018710
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24803809
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22639351
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22526552
84SOX9_26525672_Chip-Seq_HEART_Mouse1.22450214
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21730283
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.21155347
87* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20668823
88RNF2_27304074_Chip-Seq_NSC_Mouse1.19906479
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19330396
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17552758
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16954768
92* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16475507
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15915817
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.15670876
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13537361
96TCF4_23295773_ChIP-Seq_U87_Human1.13387773
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12943683
98SMAD4_21799915_ChIP-Seq_A2780_Human1.12725291
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11765790
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11226037
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11226037
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10973515
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.10763698
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09556542
105* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09137242
106MYC_22102868_ChIP-Seq_BL_Human1.08781849
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08650726
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08371023
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07968549
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07783374
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07700770
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07585336
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06454228
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05737206
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05693302
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05307450
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04791045
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.04664525
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.03931074
120TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03273067
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.02137239
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01899513
123RUNX2_22187159_ChIP-Seq_PCA_Human1.01492255
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01420203
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01115363
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.01075255
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.98707329
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97017530
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.96791055
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.96621596
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.95694914
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95581361
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.93820126
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93552204
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93124227
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.93079169
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.92027097
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90819428
139ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90650152
140* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90573106
141GATA1_19941826_ChIP-Seq_K562_Human0.89170645
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89006291
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88465096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.62550633
2MP0003787_abnormal_imprinting4.06453943
3MP0003122_maternal_imprinting3.18091301
4MP0003121_genomic_imprinting2.73137060
5MP0003300_gastrointestinal_ulcer2.62188103
6MP0006292_abnormal_olfactory_placode2.45341458
7MP0003045_fibrosis2.39710270
8MP0010030_abnormal_orbit_morphology2.15377110
9MP0009780_abnormal_chondrocyte_physiolo2.14077999
10MP0000566_synostosis2.06431901
11MP0005551_abnormal_eye_electrophysiolog1.87749136
12MP0001188_hyperpigmentation1.82566880
13MP0006072_abnormal_retinal_apoptosis1.79666368
14MP0005076_abnormal_cell_differentiation1.73188332
15MP0008961_abnormal_basal_metabolism1.72802326
16MP0001299_abnormal_eye_distance/1.70312380
17MP0004859_abnormal_synaptic_plasticity1.69233192
18MP0003941_abnormal_skin_development1.69003938
19MP0003123_paternal_imprinting1.65447809
20MP0004885_abnormal_endolymph1.64896856
21MP0009046_muscle_twitch1.62674894
22MP0008569_lethality_at_weaning1.62410165
23MP0001486_abnormal_startle_reflex1.59450813
24MP0009703_decreased_birth_body1.58127787
25MP0003385_abnormal_body_wall1.57736478
26MP0002009_preneoplasia1.57088480
27MP0003283_abnormal_digestive_organ1.55804752
28MP0001293_anophthalmia1.53022344
29MP0003136_yellow_coat_color1.50640358
30MP0000778_abnormal_nervous_system1.46202188
31MP0003690_abnormal_glial_cell1.46022943
32MP0000003_abnormal_adipose_tissue1.45476753
33MP0003935_abnormal_craniofacial_develop1.45336053
34MP0003119_abnormal_digestive_system1.44462528
35MP0002938_white_spotting1.41922608
36MP0000428_abnormal_craniofacial_morphol1.38978661
37MP0004133_heterotaxia1.38218115
38MP0003942_abnormal_urinary_system1.35136083
39MP0003763_abnormal_thymus_physiology1.34829299
40MP0000920_abnormal_myelination1.34409890
41MP0005423_abnormal_somatic_nervous1.33414066
42MP0004270_analgesia1.33144159
43MP0001286_abnormal_eye_development1.31573822
44MP0003635_abnormal_synaptic_transmissio1.31001087
45MP0005623_abnormal_meninges_morphology1.30940998
46MP0003567_abnormal_fetal_cardiomyocyte1.30827763
47MP0000049_abnormal_middle_ear1.27449972
48MP0002928_abnormal_bile_duct1.26830352
49MP0009278_abnormal_bone_marrow1.26348091
50MP0002233_abnormal_nose_morphology1.24765496
51MP0003890_abnormal_embryonic-extraembry1.20258978
52MP0004145_abnormal_muscle_electrophysio1.19695527
53MP0000534_abnormal_ureter_morphology1.19246707
54MP0008877_abnormal_DNA_methylation1.18521143
55MP0003183_abnormal_peptide_metabolism1.18285192
56MP0000733_abnormal_muscle_development1.16498218
57MP0003111_abnormal_nucleus_morphology1.16071453
58MP0005248_abnormal_Harderian_gland1.15035575
59MP0002166_altered_tumor_susceptibility1.14836131
60MP0002085_abnormal_embryonic_tissue1.14722991
61MP0002064_seizures1.14447901
62MP0005253_abnormal_eye_physiology1.13946525
63MP0003937_abnormal_limbs/digits/tail_de1.13783773
64MP0003938_abnormal_ear_development1.12452785
65MP0009672_abnormal_birth_weight1.12128198
66MP0002249_abnormal_larynx_morphology1.10587277
67MP0003091_abnormal_cell_migration1.06972932
68MP0003115_abnormal_respiratory_system1.06646384
69MP0002184_abnormal_innervation1.05757268
70MP0005499_abnormal_olfactory_system1.05569176
71MP0005394_taste/olfaction_phenotype1.05569176
72MP0004233_abnormal_muscle_weight1.05168205
73MP0000432_abnormal_head_morphology1.04416448
74MP0005503_abnormal_tendon_morphology1.04144012
75MP0005375_adipose_tissue_phenotype1.01442121
76MP0004197_abnormal_fetal_growth/weight/1.00967821
77MP0001270_distended_abdomen1.00801367
78MP0002925_abnormal_cardiovascular_devel0.99956496
79MP0009250_abnormal_appendicular_skeleto0.99656680
80MP0002108_abnormal_muscle_morphology0.98479971
81MP0003634_abnormal_glial_cell0.98099717
82MP0005174_abnormal_tail_pigmentation0.98013107
83MP0002067_abnormal_sensory_capabilities0.96910763
84MP0002152_abnormal_brain_morphology0.96063562
85MP0003950_abnormal_plasma_membrane0.95936381
86MP0000579_abnormal_nail_morphology0.95863350
87MP0002697_abnormal_eye_size0.95187709
88MP0001672_abnormal_embryogenesis/_devel0.94587520
89MP0005380_embryogenesis_phenotype0.94587520
90MP0001177_atelectasis0.93993447
91MP0003861_abnormal_nervous_system0.92600244
92MP0009384_cardiac_valve_regurgitation0.91527183
93MP0001873_stomach_inflammation0.91212428
94MP0003984_embryonic_growth_retardation0.91120149
95MP0005409_darkened_coat_color0.91028706
96MP0002088_abnormal_embryonic_growth/wei0.90953401
97MP0000703_abnormal_thymus_morphology0.90918291
98MP0001984_abnormal_olfaction0.90110258
99MP0000462_abnormal_digestive_system0.90045141
100MP0003705_abnormal_hypodermis_morpholog0.89930119
101MP0000631_abnormal_neuroendocrine_gland0.89916460
102MP0001730_embryonic_growth_arrest0.88968810
103MP0000955_abnormal_spinal_cord0.88921501
104MP0002882_abnormal_neuron_morphology0.88838724
105MP0009745_abnormal_behavioral_response0.88282819
106MP0010094_abnormal_chromosome_stability0.88008593
107MP0008057_abnormal_DNA_replication0.87589798
108MP0005187_abnormal_penis_morphology0.87540557
109MP0002063_abnormal_learning/memory/cond0.86820728
110MP0003252_abnormal_bile_duct0.86688713
111MP0005391_vision/eye_phenotype0.85704229
112MP0005195_abnormal_posterior_eye0.85486302
113MP0000537_abnormal_urethra_morphology0.85150263
114MP0003693_abnormal_embryo_hatching0.85085050
115MP0002114_abnormal_axial_skeleton0.84870676
116MP0003868_abnormal_feces_composition0.83940430
117MP0002089_abnormal_postnatal_growth/wei0.83669748
118MP0010368_abnormal_lymphatic_system0.83238008
119MP0001784_abnormal_fluid_regulation0.82727289
120MP0002272_abnormal_nervous_system0.82600087
121MP0002557_abnormal_social/conspecific_i0.82227638
122MP0003172_abnormal_lysosome_physiology0.81680114
123MP0003718_maternal_effect0.81340355
124MP0008789_abnormal_olfactory_epithelium0.81097470
125MP0001697_abnormal_embryo_size0.80761657
126MP0005645_abnormal_hypothalamus_physiol0.80049498
127MP0003880_abnormal_central_pattern0.79414772
128MP0003755_abnormal_palate_morphology0.79386120
129MP0004742_abnormal_vestibular_system0.79372093
130MP0002734_abnormal_mechanical_nocicepti0.78809157
131MP0002638_abnormal_pupillary_reflex0.78602629
132MP0002751_abnormal_autonomic_nervous0.78104462
133MP0002111_abnormal_tail_morphology0.78061490
134MP0002084_abnormal_developmental_patter0.77217660
135MP0001849_ear_inflammation0.76941927
136MP0002229_neurodegeneration0.76307276
137MP0008932_abnormal_embryonic_tissue0.75855997
138MP0003866_abnormal_defecation0.75484100
139MP0002116_abnormal_craniofacial_bone0.74924761
140MP0006276_abnormal_autonomic_nervous0.74851342
141MP0002572_abnormal_emotion/affect_behav0.74220584
142MP0001502_abnormal_circadian_rhythm0.73827397
143MP0002081_perinatal_lethality0.73335366
144MP0002092_abnormal_eye_morphology0.72314441
145MP0005670_abnormal_white_adipose0.72288671
146MP0003632_abnormal_nervous_system0.71536570
147MP0004811_abnormal_neuron_physiology0.71516960
148MP0002932_abnormal_joint_morphology0.71335557
149MP0010769_abnormal_survival0.71242322
150MP0003303_peritoneal_inflammation0.71223284
151MP0001340_abnormal_eyelid_morphology0.70707515
152MP0010678_abnormal_skin_adnexa0.70505176
153MP0004134_abnormal_chest_morphology0.70112577
154MP0008770_decreased_survivor_rate0.69940865
155MP0004185_abnormal_adipocyte_glucose0.69830980
156MP0001851_eye_inflammation0.69659176
157MP0002752_abnormal_somatic_nervous0.69483613

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.40331081
2Macroorchidism (HP:0000053)4.31962367
3Hepatoblastoma (HP:0002884)3.69853084
4Narrow palate (HP:0000189)3.07717727
5Volvulus (HP:0002580)3.01863767
6Aplasia/Hypoplasia of the sternum (HP:0006714)2.90610502
7T lymphocytopenia (HP:0005403)2.90215462
8Hyperacusis (HP:0010780)2.77690853
9Heterotopia (HP:0002282)2.71036118
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63485248
11Short 4th metacarpal (HP:0010044)2.63485248
12Abnormality of the nasal septum (HP:0000419)2.61341025
13Protruding tongue (HP:0010808)2.60474122
14Abnormality of T cell number (HP:0011839)2.58331623
15Long eyelashes (HP:0000527)2.53606519
16Chromsome breakage (HP:0040012)2.52081833
17Septo-optic dysplasia (HP:0100842)2.49411603
18Trigonocephaly (HP:0000243)2.48425680
19Abnormality of the labia minora (HP:0012880)2.47123289
20Obsessive-compulsive behavior (HP:0000722)2.40994122
21Genetic anticipation (HP:0003743)2.39764931
22Ectopic kidney (HP:0000086)2.33190351
23Birth length less than 3rd percentile (HP:0003561)2.27440878
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26896032
25Shallow orbits (HP:0000586)2.26732986
26Bronchomalacia (HP:0002780)2.26413880
27Anteriorly placed anus (HP:0001545)2.25978672
28Renovascular hypertension (HP:0100817)2.24229346
29Elfin facies (HP:0004428)2.22218489
30Anal stenosis (HP:0002025)2.21710110
31Cerebral aneurysm (HP:0004944)2.20711598
32Abnormality of the 4th metacarpal (HP:0010012)2.19117496
33Supernumerary ribs (HP:0005815)2.14094126
34Truncal obesity (HP:0001956)2.13434513
35Vertebral arch anomaly (HP:0008438)2.13201581
36Renal duplication (HP:0000075)2.12906840
37Broad metatarsal (HP:0001783)2.12220084
38Urethral obstruction (HP:0000796)2.07850353
39Nephroblastoma (Wilms tumor) (HP:0002667)2.07636945
40Congenital stationary night blindness (HP:0007642)2.05821374
41Neoplasm of the heart (HP:0100544)2.05229147
42Pseudobulbar signs (HP:0002200)2.04704025
43Overriding aorta (HP:0002623)2.04296639
44Hemiplegia (HP:0002301)2.00062801
45Broad thumb (HP:0011304)1.99713369
46Lip pit (HP:0100267)1.99323034
47Aortic aneurysm (HP:0004942)1.97997877
48Cutaneous finger syndactyly (HP:0010554)1.97720499
49Embryonal renal neoplasm (HP:0011794)1.94659949
50Thick eyebrow (HP:0000574)1.93469171
51Overgrowth (HP:0001548)1.93256147
52Midline defect of the nose (HP:0004122)1.91417442
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90533642
54Neonatal hypoglycemia (HP:0001998)1.89816996
55Progressive cerebellar ataxia (HP:0002073)1.87779238
56Hyperventilation (HP:0002883)1.87293159
57Hypoplasia of the maxilla (HP:0000327)1.87249494
58Disproportionate tall stature (HP:0001519)1.86816086
59Diastasis recti (HP:0001540)1.86755895
60Choanal stenosis (HP:0000452)1.86688913
61Hypoplastic ischia (HP:0003175)1.86457245
62Aqueductal stenosis (HP:0002410)1.86317358
63Cutaneous syndactyly (HP:0012725)1.85977293
64Large earlobe (HP:0009748)1.83973163
65Scanning speech (HP:0002168)1.82709663
66High anterior hairline (HP:0009890)1.81000541
67Sacral dimple (HP:0000960)1.80380540
68Increased nuchal translucency (HP:0010880)1.80258610
69Flat cornea (HP:0007720)1.80256165
70Patellar aplasia (HP:0006443)1.77438990
71Colon cancer (HP:0003003)1.76849158
72Thyroiditis (HP:0100646)1.76330370
73Coronal craniosynostosis (HP:0004440)1.76169585
74Broad palm (HP:0001169)1.75275710
75Abnormality of the aortic arch (HP:0012303)1.74908545
76Drooling (HP:0002307)1.74070318
77Excessive salivation (HP:0003781)1.74070318
78Supernumerary bones of the axial skeleton (HP:0009144)1.74045696
79Dysmetric saccades (HP:0000641)1.73606535
80Turricephaly (HP:0000262)1.73094461
81Neoplasm of the oral cavity (HP:0100649)1.73064090
82Broad phalanges of the hand (HP:0009768)1.72101090
83Broad finger (HP:0001500)1.71670099
84Open mouth (HP:0000194)1.71202819
85Mitral valve prolapse (HP:0001634)1.69648904
86Papillary thyroid carcinoma (HP:0002895)1.69430814
87Abnormality of the diencephalon (HP:0010662)1.69309357
88Preaxial foot polydactyly (HP:0001841)1.68871317
89Absent frontal sinuses (HP:0002688)1.68442278
90Action tremor (HP:0002345)1.68288800
91Mask-like facies (HP:0000298)1.68243902
92Broad long bones (HP:0005622)1.67808205
93Tapered finger (HP:0001182)1.67551394
94Abnormality of the parietal bone (HP:0002696)1.66074761
95Depressed nasal tip (HP:0000437)1.66027852
96Abnormality of ocular smooth pursuit (HP:0000617)1.65460752
97Shawl scrotum (HP:0000049)1.64813873
98Buphthalmos (HP:0000557)1.64798987
99Arnold-Chiari malformation (HP:0002308)1.64294815
1002-3 toe syndactyly (HP:0004691)1.64127839
101Duplication of thumb phalanx (HP:0009942)1.63434078
102Astrocytoma (HP:0009592)1.62859000
103Abnormality of the astrocytes (HP:0100707)1.62859000
104Abnormality of the ischium (HP:0003174)1.62732719
105Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62344949
106Bilateral microphthalmos (HP:0007633)1.61813564
107Abnormality of the septum pellucidum (HP:0007375)1.61747724
108Subacute progressive viral hepatitis (HP:0006572)1.61688560
109Neoplasm of the adrenal cortex (HP:0100641)1.61510678
110Aneurysm (HP:0002617)1.61489306
111Abnormality of the corticospinal tract (HP:0002492)1.60979935
112Central scotoma (HP:0000603)1.60943746
113Low anterior hairline (HP:0000294)1.60917565
114Widely spaced teeth (HP:0000687)1.60409568
115Gastroesophageal reflux (HP:0002020)1.60344367
116Urinary bladder sphincter dysfunction (HP:0002839)1.60255190
117Insomnia (HP:0100785)1.60093985
118Pointed chin (HP:0000307)1.60019538
119Omphalocele (HP:0001539)1.59255570
120Partial duplication of thumb phalanx (HP:0009944)1.58952387
121Aplasia/Hypoplasia of the patella (HP:0006498)1.58807705
122Abnormality of the pubic bones (HP:0003172)1.58664274
123Smooth philtrum (HP:0000319)1.58590197
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58482435
125Limited elbow extension (HP:0001377)1.58078401
126Hypoplastic labia majora (HP:0000059)1.57066170
127Bowel diverticulosis (HP:0005222)1.56556716
128Anophthalmia (HP:0000528)1.56011655
129Focal seizures (HP:0007359)1.55701219
130Deep philtrum (HP:0002002)1.54802820
131Absent radius (HP:0003974)1.54320526
132Optic nerve hypoplasia (HP:0000609)1.54243036
133Abnormality of the antihelix (HP:0009738)1.53721396
134Broad phalanx (HP:0006009)1.53216171
135Prominent nose (HP:0000448)1.53183874
136Oligodactyly (hands) (HP:0001180)1.52742155
137Labial hypoplasia (HP:0000066)1.52656022
138Obstructive sleep apnea (HP:0002870)1.52420522
139Enlarged penis (HP:0000040)1.52019812
140Scrotal hypoplasia (HP:0000046)1.51911202
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.51613565
142Impulsivity (HP:0100710)1.51442992
143Partial duplication of the phalanx of hand (HP:0009999)1.50779929
144Dysmetria (HP:0001310)1.50129415
145Febrile seizures (HP:0002373)1.49877474
146Aplasia involving bones of the extremities (HP:0009825)1.49594426
147Aplasia involving bones of the upper limbs (HP:0009823)1.49594426
148Aplasia of the phalanges of the hand (HP:0009802)1.49594426
149Exotropia (HP:0000577)1.49323315
150Micropenis (HP:0000054)1.49309774
151Embryonal neoplasm (HP:0002898)1.48772592
152Absent septum pellucidum (HP:0001331)1.48547426
153Rib fusion (HP:0000902)1.48127355
154Tracheomalacia (HP:0002779)1.48084691
155Abnormal number of incisors (HP:0011064)1.46737152
156Aplasia involving forearm bones (HP:0009822)1.46607258
157Absent forearm bone (HP:0003953)1.46607258
158Abnormality of oral frenula (HP:0000190)1.46530585
159Impaired smooth pursuit (HP:0007772)1.44529869
160Broad-based gait (HP:0002136)1.44270582
161Abnormality of binocular vision (HP:0011514)1.43563115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.79669708
2CASK3.44030654
3CAMK1G3.38774800
4BRD42.90924931
5CAMK1D2.53325878
6TNIK2.36305728
7AKT32.29759484
8SIK22.15742641
9PNCK2.09153836
10MARK12.04089605
11WNK11.96822129
12CDC71.88175283
13RIPK11.82221062
14FGFR21.80791293
15LATS11.76915988
16SIK11.73134884
17MAP3K91.72978348
18MAP3K101.54252151
19PTK61.52078635
20MAP3K71.49425715
21CDK91.39819541
22FGFR31.39452526
23STK38L1.38351811
24MKNK11.35167247
25JAK11.32747222
26EPHB11.32678994
27INSRR1.32312429
28PDGFRA1.31350169
29TTK1.28928981
30CDC42BPA1.27128246
31TAF11.25881922
32SGK31.24798441
33PDGFRB1.24078140
34ICK1.23799386
35ITK1.18713778
36HIPK21.17905093
37MARK21.17529234
38MTOR1.17264320
39ALK1.15993844
40NTRK31.15232341
41CSNK1A1L1.14711485
42PRKCH1.14373109
43TTN1.12576861
44EPHA31.12065189
45MAP3K41.10735842
46PIK3CA1.10632625
47CDK61.10288267
48NTRK21.08812709
49BMPR1B1.08310617
50PRKD21.05652482
51PAK61.02632786
52TYRO31.02205453
53CSK0.99973681
54NUAK10.98831298
55ACVR1B0.97511506
56STK380.97488848
57LATS20.96666066
58DMPK0.95135771
59MAP4K10.94157717
60PKN10.93937070
61SGK20.93096846
62TAOK30.92402782
63PAK30.87954945
64MET0.87911244
65STK110.87054393
66EEF2K0.86178338
67TRIB30.84823733
68NEK20.83789978
69TSSK60.83541862
70FES0.82104226
71BRSK20.81987324
72FGFR40.80098093
73UHMK10.79429659
74MELK0.79401002
75WNK30.78795785
76WNK40.78364934
77DYRK20.77155642
78SGK4940.76382120
79SGK2230.76382120
80FGFR10.76174742
81SGK10.76091276
82CHEK10.75016510
83STK30.74563475
84TNK20.71252499
85PRKD10.70911180
86HCK0.70009704
87PLK40.68743478
88NTRK10.67909367
89MAPK100.67581577
90CLK10.67445102
91ERBB20.67134746
92CAMK40.66327944
93CAMK10.64975266
94ATR0.64010351
95PRKAA20.63650818
96NLK0.63387232
97MAPK80.63160662
98CDK10.63159996
99CDK30.61913440
100MKNK20.61196143
101PLK30.61004766
102CDK20.60789722
103GSK3B0.60712005
104PRKAA10.59450128
105MAPK140.58716474
106PTK20.58230152
107PRKDC0.57740248
108FYN0.57588298
109MAP3K130.57308193
110CSNK1G10.57081595
111LCK0.57018358
112RET0.56612973
113JAK30.56060511
114CSNK1E0.55926497
115ERBB40.53727289
116PAK20.53704060
117RPS6KA30.53139836
118IRAK20.52582592
119ATM0.52479809
120CSNK1D0.52312999
121FGR0.52286789
122PLK10.51200417
123EPHA40.50663087
124FRK0.50387025
125CDK40.49695680
126MARK30.49663131
127PRKCQ0.49190147
128DYRK1A0.48993336
129WEE10.48497163
130JAK20.47998270
131PRKCG0.47793693
132TGFBR10.47741518
133MAPK10.47682554
134PKN20.47109186
135CSNK1G20.46438810
136STK390.46400384
137PRKG10.46302211
138INSR0.46130965
139CHEK20.46005834
140KSR10.44540889
141MAPK130.44214778
142PLK20.43928911
143CDK50.43426718
144AKT10.40819745

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.51340166
2Type II diabetes mellitus_Homo sapiens_hsa049301.87480548
3Hippo signaling pathway_Homo sapiens_hsa043901.73672581
4Dorso-ventral axis formation_Homo sapiens_hsa043201.53693761
5GABAergic synapse_Homo sapiens_hsa047271.48450201
6Morphine addiction_Homo sapiens_hsa050321.48109611
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48096594
8Nicotine addiction_Homo sapiens_hsa050331.45425568
9Glutamatergic synapse_Homo sapiens_hsa047241.44892660
10Non-homologous end-joining_Homo sapiens_hsa034501.44448078
11Insulin secretion_Homo sapiens_hsa049111.42053514
12Primary immunodeficiency_Homo sapiens_hsa053401.41377578
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41040671
14Cell cycle_Homo sapiens_hsa041101.40700003
15Basal transcription factors_Homo sapiens_hsa030221.30896009
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29489786
17T cell receptor signaling pathway_Homo sapiens_hsa046601.29384901
18Renin secretion_Homo sapiens_hsa049241.28979241
19Circadian entrainment_Homo sapiens_hsa047131.28660507
20TGF-beta signaling pathway_Homo sapiens_hsa043501.26970694
21Tight junction_Homo sapiens_hsa045301.26938150
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26128009
23Selenocompound metabolism_Homo sapiens_hsa004501.25473515
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22974835
25Salivary secretion_Homo sapiens_hsa049701.21993580
26Long-term depression_Homo sapiens_hsa047301.21968307
27Nitrogen metabolism_Homo sapiens_hsa009101.19060842
28Circadian rhythm_Homo sapiens_hsa047101.19013424
29Cholinergic synapse_Homo sapiens_hsa047251.17674896
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.17581601
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16468555
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16343292
33Chronic myeloid leukemia_Homo sapiens_hsa052201.15731464
34Long-term potentiation_Homo sapiens_hsa047201.14619157
35mTOR signaling pathway_Homo sapiens_hsa041501.14043191
36Gastric acid secretion_Homo sapiens_hsa049711.13673790
37RNA transport_Homo sapiens_hsa030131.13647081
38Notch signaling pathway_Homo sapiens_hsa043301.12594758
39Thyroid cancer_Homo sapiens_hsa052161.12071420
40Axon guidance_Homo sapiens_hsa043601.11928183
41B cell receptor signaling pathway_Homo sapiens_hsa046621.11253860
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09659871
43Basal cell carcinoma_Homo sapiens_hsa052171.08920520
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08039762
45Dilated cardiomyopathy_Homo sapiens_hsa054141.07566667
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06044979
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05860556
48Renal cell carcinoma_Homo sapiens_hsa052111.03628713
49Estrogen signaling pathway_Homo sapiens_hsa049151.02364515
50Choline metabolism in cancer_Homo sapiens_hsa052311.01689440
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00865817
52cAMP signaling pathway_Homo sapiens_hsa040241.00336036
53Prostate cancer_Homo sapiens_hsa052150.99759080
54GnRH signaling pathway_Homo sapiens_hsa049120.99697799
55Endometrial cancer_Homo sapiens_hsa052130.99276056
56Wnt signaling pathway_Homo sapiens_hsa043100.98679779
57MicroRNAs in cancer_Homo sapiens_hsa052060.98026785
58Fatty acid biosynthesis_Homo sapiens_hsa000610.95734143
59Oxytocin signaling pathway_Homo sapiens_hsa049210.95022359
60Platelet activation_Homo sapiens_hsa046110.94626210
61ErbB signaling pathway_Homo sapiens_hsa040120.94440893
62Proteoglycans in cancer_Homo sapiens_hsa052050.93073702
63Phototransduction_Homo sapiens_hsa047440.92322208
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91896561
65Glioma_Homo sapiens_hsa052140.91870544
66Insulin resistance_Homo sapiens_hsa049310.91546409
67Inositol phosphate metabolism_Homo sapiens_hsa005620.91462736
68Adherens junction_Homo sapiens_hsa045200.91252625
69Cocaine addiction_Homo sapiens_hsa050300.90987843
70Fanconi anemia pathway_Homo sapiens_hsa034600.90243252
71Glucagon signaling pathway_Homo sapiens_hsa049220.90189378
72MAPK signaling pathway_Homo sapiens_hsa040100.89685039
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88724344
74Dopaminergic synapse_Homo sapiens_hsa047280.88430529
75ABC transporters_Homo sapiens_hsa020100.88417370
76Melanogenesis_Homo sapiens_hsa049160.87501128
77Chemokine signaling pathway_Homo sapiens_hsa040620.87271897
78Olfactory transduction_Homo sapiens_hsa047400.86863501
79Gap junction_Homo sapiens_hsa045400.86685317
80Colorectal cancer_Homo sapiens_hsa052100.86511356
81Focal adhesion_Homo sapiens_hsa045100.86038163
82Non-small cell lung cancer_Homo sapiens_hsa052230.86012486
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85951346
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85663159
85Taste transduction_Homo sapiens_hsa047420.85505787
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82444808
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81881697
88Oocyte meiosis_Homo sapiens_hsa041140.80944321
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.79968999
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79566537
91RNA degradation_Homo sapiens_hsa030180.79384372
92mRNA surveillance pathway_Homo sapiens_hsa030150.79174530
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78971969
94Pancreatic secretion_Homo sapiens_hsa049720.78888200
95Melanoma_Homo sapiens_hsa052180.78263228
96Hedgehog signaling pathway_Homo sapiens_hsa043400.76803848
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76651655
98Pancreatic cancer_Homo sapiens_hsa052120.76358001
99Thyroid hormone synthesis_Homo sapiens_hsa049180.76117157
100Calcium signaling pathway_Homo sapiens_hsa040200.75653511
101FoxO signaling pathway_Homo sapiens_hsa040680.74971886
102Vitamin B6 metabolism_Homo sapiens_hsa007500.73781388
103Pathways in cancer_Homo sapiens_hsa052000.72949237
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72581823
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72290935
106Rap1 signaling pathway_Homo sapiens_hsa040150.72095032
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71878062
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71094917
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71038440
110Spliceosome_Homo sapiens_hsa030400.70302866
111Serotonergic synapse_Homo sapiens_hsa047260.70273888
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.70106365
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69750382
114ECM-receptor interaction_Homo sapiens_hsa045120.68694723
115Insulin signaling pathway_Homo sapiens_hsa049100.68415248
116Osteoclast differentiation_Homo sapiens_hsa043800.67813002
117Ovarian steroidogenesis_Homo sapiens_hsa049130.66620511
118Acute myeloid leukemia_Homo sapiens_hsa052210.65947393
119Prolactin signaling pathway_Homo sapiens_hsa049170.65923273
120Amphetamine addiction_Homo sapiens_hsa050310.65910861
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64079450
122AMPK signaling pathway_Homo sapiens_hsa041520.64011440
123Viral myocarditis_Homo sapiens_hsa054160.63688523
124Bile secretion_Homo sapiens_hsa049760.63067126
125Ras signaling pathway_Homo sapiens_hsa040140.61931611
126Steroid biosynthesis_Homo sapiens_hsa001000.60567744
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.58357668
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57103564
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55343963

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »