

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.28650957 |
| 2 | synaptic vesicle maturation (GO:0016188) | 4.07783255 |
| 3 | behavioral response to nicotine (GO:0035095) | 3.87882097 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.86953674 |
| 5 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.86844504 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.85150751 |
| 7 | activated T cell proliferation (GO:0050798) | 3.74990591 |
| 8 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.67816882 |
| 9 | histone H3-K4 trimethylation (GO:0080182) | 3.67427686 |
| 10 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.56790223 |
| 11 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.54549124 |
| 12 | locomotory exploration behavior (GO:0035641) | 3.52400723 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.43314714 |
| 14 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.39780408 |
| 15 | dendrite morphogenesis (GO:0048813) | 3.35572573 |
| 16 | vocalization behavior (GO:0071625) | 3.24376333 |
| 17 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.23508367 |
| 18 | neuronal action potential propagation (GO:0019227) | 3.22629562 |
| 19 | nucleobase catabolic process (GO:0046113) | 3.18743592 |
| 20 | synaptic transmission, glutamatergic (GO:0035249) | 3.15968856 |
| 21 | gamma-aminobutyric acid transport (GO:0015812) | 3.15931322 |
| 22 | protein localization to synapse (GO:0035418) | 3.12015982 |
| 23 | cerebellar granule cell differentiation (GO:0021707) | 3.11879282 |
| 24 | dendritic spine morphogenesis (GO:0060997) | 3.11431411 |
| 25 | mechanosensory behavior (GO:0007638) | 3.05831191 |
| 26 | glutamate receptor signaling pathway (GO:0007215) | 2.98279103 |
| 27 | central nervous system myelination (GO:0022010) | 2.96786220 |
| 28 | axon ensheathment in central nervous system (GO:0032291) | 2.96786220 |
| 29 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.92943868 |
| 30 | positive regulation of synapse assembly (GO:0051965) | 2.92506270 |
| 31 | neuron recognition (GO:0008038) | 2.91364356 |
| 32 | layer formation in cerebral cortex (GO:0021819) | 2.89067957 |
| 33 | head development (GO:0060322) | 2.87947472 |
| 34 | synaptic vesicle exocytosis (GO:0016079) | 2.83549327 |
| 35 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.83377666 |
| 36 | histone H3-K4 methylation (GO:0051568) | 2.82951732 |
| 37 | axonal fasciculation (GO:0007413) | 2.79456398 |
| 38 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.79264798 |
| 39 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.78343666 |
| 40 | establishment of mitochondrion localization (GO:0051654) | 2.77930441 |
| 41 | mRNA splice site selection (GO:0006376) | 2.77496688 |
| 42 | neuromuscular synaptic transmission (GO:0007274) | 2.77374547 |
| 43 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.77318385 |
| 44 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.77222972 |
| 45 | adult walking behavior (GO:0007628) | 2.76720939 |
| 46 | presynaptic membrane assembly (GO:0097105) | 2.75812184 |
| 47 | forebrain neuron differentiation (GO:0021879) | 2.74115776 |
| 48 | neuron cell-cell adhesion (GO:0007158) | 2.74054533 |
| 49 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.70121729 |
| 50 | membrane depolarization during action potential (GO:0086010) | 2.68142325 |
| 51 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.68136006 |
| 52 | postsynaptic membrane organization (GO:0001941) | 2.67169532 |
| 53 | neuron-neuron synaptic transmission (GO:0007270) | 2.66569858 |
| 54 | startle response (GO:0001964) | 2.63677420 |
| 55 | regulation of collateral sprouting (GO:0048670) | 2.63524948 |
| 56 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.63460114 |
| 57 | negative regulation of cell killing (GO:0031342) | 2.63460114 |
| 58 | neuronal action potential (GO:0019228) | 2.61717704 |
| 59 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.61326438 |
| 60 | exploration behavior (GO:0035640) | 2.60948155 |
| 61 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.60751405 |
| 62 | long-term memory (GO:0007616) | 2.59603986 |
| 63 | regulation of postsynaptic membrane potential (GO:0060078) | 2.59060399 |
| 64 | dendrite development (GO:0016358) | 2.57706581 |
| 65 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.57083133 |
| 66 | peptidyl-lysine trimethylation (GO:0018023) | 2.56136240 |
| 67 | cell migration in hindbrain (GO:0021535) | 2.52248090 |
| 68 | stress granule assembly (GO:0034063) | 2.51926006 |
| 69 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.51797760 |
| 70 | otic vesicle formation (GO:0030916) | 2.51446081 |
| 71 | somite development (GO:0061053) | 2.50658454 |
| 72 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.50620442 |
| 73 | neurotransmitter secretion (GO:0007269) | 2.50253935 |
| 74 | synaptic transmission, cholinergic (GO:0007271) | 2.49580553 |
| 75 | glutamate secretion (GO:0014047) | 2.48517486 |
| 76 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.47758648 |
| 77 | regulation of respiratory gaseous exchange (GO:0043576) | 2.47223717 |
| 78 | regulation of Rap GTPase activity (GO:0032317) | 2.46131826 |
| 79 | synapse organization (GO:0050808) | 2.45687597 |
| 80 | central nervous system neuron differentiation (GO:0021953) | 2.44706816 |
| 81 | negative regulation of axonogenesis (GO:0050771) | 2.44146309 |
| 82 | presynaptic membrane organization (GO:0097090) | 2.43717907 |
| 83 | cochlea development (GO:0090102) | 2.43317368 |
| 84 | retinal ganglion cell axon guidance (GO:0031290) | 2.43265284 |
| 85 | establishment of protein localization to Golgi (GO:0072600) | 2.43061735 |
| 86 | histone lysine methylation (GO:0034968) | 2.42739921 |
| 87 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.42300130 |
| 88 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.41433982 |
| 89 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.40937901 |
| 90 | urinary tract smooth muscle contraction (GO:0014848) | 2.40549777 |
| 91 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.40536076 |
| 92 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.40407355 |
| 93 | regulation of synapse structural plasticity (GO:0051823) | 2.39543983 |
| 94 | positive regulation of CREB transcription factor activity (GO:0032793) | 2.39206643 |
| 95 | positive regulation of synapse maturation (GO:0090129) | 2.37910028 |
| 96 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.37656519 |
| 97 | neuronal stem cell maintenance (GO:0097150) | 2.37612794 |
| 98 | retina layer formation (GO:0010842) | 2.37414281 |
| 99 | cAMP catabolic process (GO:0006198) | 2.35900068 |
| 100 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.35883945 |
| 101 | generation of neurons (GO:0048699) | 2.35808273 |
| 102 | response to auditory stimulus (GO:0010996) | 2.35658786 |
| 103 | histone H3-K36 demethylation (GO:0070544) | 2.35183694 |
| 104 | synaptic vesicle endocytosis (GO:0048488) | 2.34661899 |
| 105 | innervation (GO:0060384) | 2.34660693 |
| 106 | positive regulation of membrane potential (GO:0045838) | 2.34646468 |
| 107 | transmission of nerve impulse (GO:0019226) | 2.32480614 |
| 108 | limb bud formation (GO:0060174) | 2.31668226 |
| 109 | adult behavior (GO:0030534) | 2.31365332 |
| 110 | membrane depolarization (GO:0051899) | 2.31275513 |
| 111 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.29593122 |
| 112 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.28553817 |
| 113 | establishment of nucleus localization (GO:0040023) | 2.27471779 |
| 114 | vesicle transport along microtubule (GO:0047496) | 2.27413876 |
| 115 | regulation of synaptic vesicle transport (GO:1902803) | 2.27306374 |
| 116 | nerve growth factor signaling pathway (GO:0038180) | 2.26891029 |
| 117 | * negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.25090502 |
| 118 | * regulation of translation, ncRNA-mediated (GO:0045974) | 2.25090502 |
| 119 | * negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.25090502 |
| 120 | regulation of dendritic spine development (GO:0060998) | 2.24967390 |
| 121 | positive regulation of Rap GTPase activity (GO:0032854) | 2.24698485 |
| 122 | central nervous system neuron axonogenesis (GO:0021955) | 2.22771620 |
| 123 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.22091614 |
| 124 | membrane hyperpolarization (GO:0060081) | 2.21637638 |
| 125 | regulation of neurotransmitter secretion (GO:0046928) | 2.21048212 |
| 126 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.20529020 |
| 127 | calcium ion import (GO:0070509) | 2.19525374 |
| 128 | cell differentiation in hindbrain (GO:0021533) | 2.19330176 |
| 129 | nucleus localization (GO:0051647) | 2.18881456 |
| 130 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.18576682 |
| 131 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.18089724 |
| 132 | regulation of synaptic plasticity (GO:0048167) | 2.17433870 |
| 133 | synapse assembly (GO:0007416) | 2.17210810 |
| 134 | regulation of respiratory system process (GO:0044065) | 2.16952081 |
| 135 | chromatin silencing (GO:0006342) | 2.16788437 |
| 136 | regulation of ARF protein signal transduction (GO:0032012) | 2.16643423 |
| 137 | positive regulation of fibroblast migration (GO:0010763) | 2.16246707 |
| 138 | neuronal ion channel clustering (GO:0045161) | 2.15578907 |
| 139 | cell communication by electrical coupling (GO:0010644) | 2.15508960 |
| 140 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.14598468 |
| 141 | auditory behavior (GO:0031223) | 2.13507922 |
| 142 | negative regulation of neurotransmitter transport (GO:0051589) | 2.13438431 |
| 143 | cyclic nucleotide catabolic process (GO:0009214) | 2.12293914 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.15115625 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.86183376 |
| 3 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.72365184 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.33698623 |
| 5 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.25443728 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.25443728 |
| 7 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.18873123 |
| 8 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.15055062 |
| 9 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.14443072 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.14352507 |
| 11 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.14190081 |
| 12 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.08831124 |
| 13 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.07552389 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.06863718 |
| 15 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.03344632 |
| 16 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.01049406 |
| 17 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.90804507 |
| 18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.86524587 |
| 19 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.86484185 |
| 20 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.85997702 |
| 21 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.85025260 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.81961691 |
| 23 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.76877498 |
| 24 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.75407117 |
| 25 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.74972663 |
| 26 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.74831810 |
| 27 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.73953724 |
| 28 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.70818943 |
| 29 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.69637673 |
| 30 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.65343050 |
| 31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.65005880 |
| 32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.59082073 |
| 33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.57089482 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.55560226 |
| 35 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.44411442 |
| 36 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.43555188 |
| 37 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41885653 |
| 38 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.41384010 |
| 39 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.39966672 |
| 40 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.38521525 |
| 41 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.36427060 |
| 42 | FUS_26573619_Chip-Seq_HEK293_Human | 1.36426327 |
| 43 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.34717915 |
| 44 | STAT3_23295773_ChIP-Seq_U87_Human | 1.33266248 |
| 45 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.32987971 |
| 46 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.32837790 |
| 47 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32235159 |
| 48 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.32168456 |
| 49 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.31994674 |
| 50 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.31541351 |
| 51 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.30708627 |
| 52 | AR_19668381_ChIP-Seq_PC3_Human | 1.30504947 |
| 53 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.29648376 |
| 54 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.27505861 |
| 55 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.27006196 |
| 56 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.26744862 |
| 57 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.26741408 |
| 58 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.25980381 |
| 59 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.25768316 |
| 60 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25768316 |
| 61 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.25751023 |
| 62 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.25565085 |
| 63 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.25297870 |
| 64 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.24822199 |
| 65 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.24036388 |
| 66 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.23199242 |
| 67 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.23103417 |
| 68 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.21241287 |
| 69 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.21085402 |
| 70 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.19686776 |
| 71 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.17808322 |
| 72 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.17205168 |
| 73 | TCF4_23295773_ChIP-Seq_U87_Human | 1.16920108 |
| 74 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.16399017 |
| 75 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.15171925 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.14053644 |
| 77 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.13466460 |
| 78 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.13034166 |
| 79 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.13014990 |
| 80 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11080161 |
| 81 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.10329472 |
| 82 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.09784158 |
| 83 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.09486635 |
| 84 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.09321738 |
| 85 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.09173725 |
| 86 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.08437150 |
| 87 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.08137266 |
| 88 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.07953993 |
| 89 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.07767873 |
| 90 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.07085630 |
| 91 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.06703634 |
| 92 | KDM2B_26808549_Chip-Seq_REH_Human | 1.06313445 |
| 93 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06239935 |
| 94 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.06009861 |
| 95 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.05581643 |
| 96 | * FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.05378703 |
| 97 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05325059 |
| 98 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.04650092 |
| 99 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04189023 |
| 100 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.03604398 |
| 101 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03477207 |
| 102 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.03337448 |
| 103 | P300_19829295_ChIP-Seq_ESCs_Human | 1.02725603 |
| 104 | EWS_26573619_Chip-Seq_HEK293_Human | 1.02012644 |
| 105 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.01326787 |
| 106 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.01214765 |
| 107 | * MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00510886 |
| 108 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.00458959 |
| 109 | TP53_16413492_ChIP-PET_HCT116_Human | 1.00153371 |
| 110 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.99358785 |
| 111 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99154737 |
| 112 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.98781074 |
| 113 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.98612019 |
| 114 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.98518479 |
| 115 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.97879721 |
| 116 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.97792002 |
| 117 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.97727728 |
| 118 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97558478 |
| 119 | AR_25329375_ChIP-Seq_VCAP_Human | 0.96752204 |
| 120 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.96615857 |
| 121 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.95788790 |
| 122 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.95733719 |
| 123 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.95021822 |
| 124 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.94586719 |
| 125 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.94539681 |
| 126 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.93324952 |
| 127 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.92886146 |
| 128 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.92635483 |
| 129 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90449984 |
| 130 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.89674117 |
| 131 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.89406166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.22338601 |
| 2 | MP0003880_abnormal_central_pattern | 3.27279712 |
| 3 | MP0003787_abnormal_imprinting | 3.03951742 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 2.90145441 |
| 5 | MP0005423_abnormal_somatic_nervous | 2.82281316 |
| 6 | MP0000569_abnormal_digit_pigmentation | 2.67765253 |
| 7 | MP0004270_analgesia | 2.62377703 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.26841963 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.21718857 |
| 10 | MP0009745_abnormal_behavioral_response | 2.18467885 |
| 11 | MP0005409_darkened_coat_color | 2.13568494 |
| 12 | MP0001486_abnormal_startle_reflex | 2.07584355 |
| 13 | MP0000778_abnormal_nervous_system | 2.00860070 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 1.94828152 |
| 15 | MP0004142_abnormal_muscle_tone | 1.93490096 |
| 16 | MP0002064_seizures | 1.92830892 |
| 17 | MP0008569_lethality_at_weaning | 1.88348808 |
| 18 | MP0002822_catalepsy | 1.86449644 |
| 19 | MP0000566_synostosis | 1.76402966 |
| 20 | MP0001968_abnormal_touch/_nociception | 1.75062990 |
| 21 | MP0002272_abnormal_nervous_system | 1.71957536 |
| 22 | MP0002184_abnormal_innervation | 1.69321671 |
| 23 | MP0003045_fibrosis | 1.68403646 |
| 24 | MP0005645_abnormal_hypothalamus_physiol | 1.67770229 |
| 25 | MP0006072_abnormal_retinal_apoptosis | 1.66344605 |
| 26 | MP0009046_muscle_twitch | 1.65603276 |
| 27 | MP0005646_abnormal_pituitary_gland | 1.59534899 |
| 28 | MP0002735_abnormal_chemical_nociception | 1.53823440 |
| 29 | MP0003136_yellow_coat_color | 1.53574178 |
| 30 | MP0004130_abnormal_muscle_cell | 1.53057315 |
| 31 | MP0006276_abnormal_autonomic_nervous | 1.51011997 |
| 32 | MP0004145_abnormal_muscle_electrophysio | 1.48677681 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.47053381 |
| 34 | MP0002734_abnormal_mechanical_nocicepti | 1.45353634 |
| 35 | MP0004885_abnormal_endolymph | 1.45224681 |
| 36 | MP0000751_myopathy | 1.44757423 |
| 37 | MP0005171_absent_coat_pigmentation | 1.44392370 |
| 38 | MP0002638_abnormal_pupillary_reflex | 1.43357225 |
| 39 | MP0001986_abnormal_taste_sensitivity | 1.42531875 |
| 40 | MP0002067_abnormal_sensory_capabilities | 1.42309438 |
| 41 | MP0002882_abnormal_neuron_morphology | 1.39290893 |
| 42 | MP0000955_abnormal_spinal_cord | 1.35648417 |
| 43 | MP0004811_abnormal_neuron_physiology | 1.34157996 |
| 44 | MP0005551_abnormal_eye_electrophysiolog | 1.32498406 |
| 45 | MP0001188_hyperpigmentation | 1.31691201 |
| 46 | MP0004133_heterotaxia | 1.31015506 |
| 47 | MP0003938_abnormal_ear_development | 1.30817804 |
| 48 | MP0009780_abnormal_chondrocyte_physiolo | 1.29817700 |
| 49 | MP0005394_taste/olfaction_phenotype | 1.26718068 |
| 50 | MP0005499_abnormal_olfactory_system | 1.26718068 |
| 51 | MP0000631_abnormal_neuroendocrine_gland | 1.24548254 |
| 52 | MP0005623_abnormal_meninges_morphology | 1.22897182 |
| 53 | MP0005377_hearing/vestibular/ear_phenot | 1.22285279 |
| 54 | MP0003878_abnormal_ear_physiology | 1.22285279 |
| 55 | MP0006292_abnormal_olfactory_placode | 1.20448473 |
| 56 | MP0000026_abnormal_inner_ear | 1.15620296 |
| 57 | MP0001984_abnormal_olfaction | 1.15032215 |
| 58 | MP0002152_abnormal_brain_morphology | 1.14860020 |
| 59 | MP0001440_abnormal_grooming_behavior | 1.11180452 |
| 60 | MP0003890_abnormal_embryonic-extraembry | 1.09369876 |
| 61 | MP0004215_abnormal_myocardial_fiber | 1.07128851 |
| 62 | MP0003861_abnormal_nervous_system | 1.04288493 |
| 63 | MP0003121_genomic_imprinting | 1.03817365 |
| 64 | MP0003879_abnormal_hair_cell | 1.01361527 |
| 65 | MP0002653_abnormal_ependyma_morphology | 1.01135471 |
| 66 | MP0004924_abnormal_behavior | 0.99201511 |
| 67 | MP0005386_behavior/neurological_phenoty | 0.99201511 |
| 68 | MP0001970_abnormal_pain_threshold | 0.99005606 |
| 69 | MP0003385_abnormal_body_wall | 0.98803148 |
| 70 | MP0005253_abnormal_eye_physiology | 0.98545969 |
| 71 | MP0001502_abnormal_circadian_rhythm | 0.98258890 |
| 72 | MP0002752_abnormal_somatic_nervous | 0.94914516 |
| 73 | MP0004085_abnormal_heartbeat | 0.94280723 |
| 74 | MP0000015_abnormal_ear_pigmentation | 0.94129883 |
| 75 | MP0002928_abnormal_bile_duct | 0.93612683 |
| 76 | MP0003119_abnormal_digestive_system | 0.92857370 |
| 77 | MP0004742_abnormal_vestibular_system | 0.92614489 |
| 78 | MP0005174_abnormal_tail_pigmentation | 0.92033648 |
| 79 | MP0002066_abnormal_motor_capabilities/c | 0.91733569 |
| 80 | MP0001501_abnormal_sleep_pattern | 0.91163698 |
| 81 | MP0003122_maternal_imprinting | 0.89780495 |
| 82 | MP0005076_abnormal_cell_differentiation | 0.89248081 |
| 83 | MP0008961_abnormal_basal_metabolism | 0.88684973 |
| 84 | MP0002102_abnormal_ear_morphology | 0.88119666 |
| 85 | MP0003690_abnormal_glial_cell | 0.88085310 |
| 86 | MP0004510_myositis | 0.87812245 |
| 87 | MP0001905_abnormal_dopamine_level | 0.87561469 |
| 88 | MP0004381_abnormal_hair_follicle | 0.87509528 |
| 89 | MP0001529_abnormal_vocalization | 0.87153172 |
| 90 | MP0002733_abnormal_thermal_nociception | 0.86209735 |
| 91 | MP0000534_abnormal_ureter_morphology | 0.85578521 |
| 92 | MP0004233_abnormal_muscle_weight | 0.85487900 |
| 93 | MP0008789_abnormal_olfactory_epithelium | 0.85319463 |
| 94 | MP0000049_abnormal_middle_ear | 0.82910638 |
| 95 | MP0002249_abnormal_larynx_morphology | 0.82178515 |
| 96 | MP0002736_abnormal_nociception_after | 0.81047699 |
| 97 | MP0005187_abnormal_penis_morphology | 0.80604617 |
| 98 | MP0003283_abnormal_digestive_organ | 0.79952453 |
| 99 | MP0003698_abnormal_male_reproductive | 0.79155534 |
| 100 | MP0002229_neurodegeneration | 0.78860938 |
| 101 | MP0004134_abnormal_chest_morphology | 0.77940295 |
| 102 | MP0002837_dystrophic_cardiac_calcinosis | 0.77384765 |
| 103 | MP0002751_abnormal_autonomic_nervous | 0.75873495 |
| 104 | MP0001293_anophthalmia | 0.75537228 |
| 105 | MP0002069_abnormal_eating/drinking_beha | 0.75466013 |
| 106 | MP0002277_abnormal_respiratory_mucosa | 0.74358112 |
| 107 | MP0003935_abnormal_craniofacial_develop | 0.74296086 |
| 108 | MP0003633_abnormal_nervous_system | 0.73889087 |
| 109 | MP0001177_atelectasis | 0.72652784 |
| 110 | MP0003631_nervous_system_phenotype | 0.72477518 |
| 111 | MP0002081_perinatal_lethality | 0.72222447 |
| 112 | MP0009379_abnormal_foot_pigmentation | 0.70785749 |
| 113 | MP0002009_preneoplasia | 0.70234465 |
| 114 | MP0002127_abnormal_cardiovascular_syste | 0.69489814 |
| 115 | MP0005195_abnormal_posterior_eye | 0.68204984 |
| 116 | MP0002116_abnormal_craniofacial_bone | 0.67800404 |
| 117 | MP0001963_abnormal_hearing_physiology | 0.67684520 |
| 118 | MP0004484_altered_response_of | 0.65535120 |
| 119 | MP0002082_postnatal_lethality | 0.65099216 |
| 120 | MP0010770_preweaning_lethality | 0.65099216 |
| 121 | MP0003634_abnormal_glial_cell | 0.64551144 |
| 122 | MP0010769_abnormal_survival | 0.64294367 |
| 123 | MP0008872_abnormal_physiological_respon | 0.64124532 |
| 124 | MP0001943_abnormal_respiration | 0.62259413 |
| 125 | MP0003632_abnormal_nervous_system | 0.61615357 |
| 126 | MP0000920_abnormal_myelination | 0.60838276 |
| 127 | MP0001324_abnormal_eye_pigmentation | 0.60799418 |
| 128 | MP0008874_decreased_physiological_sensi | 0.60346122 |
| 129 | MP0001485_abnormal_pinna_reflex | 0.59617178 |
| 130 | MP0002108_abnormal_muscle_morphology | 0.59283007 |
| 131 | MP0005391_vision/eye_phenotype | 0.59212498 |
| 132 | MP0003137_abnormal_impulse_conducting | 0.58918556 |
| 133 | MP0002075_abnormal_coat/hair_pigmentati | 0.58608910 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 3.59012867 |
| 2 | Papilledema (HP:0001085) | 3.56409268 |
| 3 | Macroorchidism (HP:0000053) | 3.11589544 |
| 4 | Febrile seizures (HP:0002373) | 3.07800323 |
| 5 | Focal seizures (HP:0007359) | 3.02937776 |
| 6 | Abnormality of the fingertips (HP:0001211) | 2.97702500 |
| 7 | Limb dystonia (HP:0002451) | 2.95422061 |
| 8 | Chronic hepatic failure (HP:0100626) | 2.73691060 |
| 9 | Epileptic encephalopathy (HP:0200134) | 2.70868299 |
| 10 | Genetic anticipation (HP:0003743) | 2.66208340 |
| 11 | Gaze-evoked nystagmus (HP:0000640) | 2.60510218 |
| 12 | Broad-based gait (HP:0002136) | 2.56983901 |
| 13 | Sleep apnea (HP:0010535) | 2.56177333 |
| 14 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.51148937 |
| 15 | Short 4th metacarpal (HP:0010044) | 2.51148937 |
| 16 | Nephronophthisis (HP:0000090) | 2.49832130 |
| 17 | Progressive cerebellar ataxia (HP:0002073) | 2.44692126 |
| 18 | Myokymia (HP:0002411) | 2.42113503 |
| 19 | Postural instability (HP:0002172) | 2.41689059 |
| 20 | Trigonocephaly (HP:0000243) | 2.41593415 |
| 21 | Dialeptic seizures (HP:0011146) | 2.40657365 |
| 22 | Hepatoblastoma (HP:0002884) | 2.40115215 |
| 23 | Excessive salivation (HP:0003781) | 2.39736972 |
| 24 | Drooling (HP:0002307) | 2.39736972 |
| 25 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.39465356 |
| 26 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.39465356 |
| 27 | Molar tooth sign on MRI (HP:0002419) | 2.38477874 |
| 28 | Abnormality of midbrain morphology (HP:0002418) | 2.38477874 |
| 29 | Protruding tongue (HP:0010808) | 2.37462517 |
| 30 | Aqueductal stenosis (HP:0002410) | 2.37244161 |
| 31 | Obstructive sleep apnea (HP:0002870) | 2.36883143 |
| 32 | Pancreatic fibrosis (HP:0100732) | 2.35545502 |
| 33 | Abnormality of the corticospinal tract (HP:0002492) | 2.35161650 |
| 34 | Abnormality of the labia minora (HP:0012880) | 2.32502821 |
| 35 | Action tremor (HP:0002345) | 2.31956965 |
| 36 | Pancreatic cysts (HP:0001737) | 2.31286628 |
| 37 | Midline defect of the nose (HP:0004122) | 2.29391724 |
| 38 | Long eyelashes (HP:0000527) | 2.28956249 |
| 39 | Absence seizures (HP:0002121) | 2.22973852 |
| 40 | Volvulus (HP:0002580) | 2.22891970 |
| 41 | True hermaphroditism (HP:0010459) | 2.22029965 |
| 42 | Abnormality of the lower motor neuron (HP:0002366) | 2.17820148 |
| 43 | Abnormality of the astrocytes (HP:0100707) | 2.13727284 |
| 44 | Astrocytoma (HP:0009592) | 2.13727284 |
| 45 | Oligodactyly (hands) (HP:0001180) | 2.12991810 |
| 46 | Diplopia (HP:0000651) | 2.12962598 |
| 47 | Abnormality of binocular vision (HP:0011514) | 2.12962598 |
| 48 | Narrow palate (HP:0000189) | 2.12185238 |
| 49 | Absent speech (HP:0001344) | 2.09851807 |
| 50 | Septo-optic dysplasia (HP:0100842) | 2.08196166 |
| 51 | Abnormal eating behavior (HP:0100738) | 2.05863650 |
| 52 | Elfin facies (HP:0004428) | 2.05586872 |
| 53 | Obsessive-compulsive behavior (HP:0000722) | 2.05358692 |
| 54 | Abnormality of the renal medulla (HP:0100957) | 2.04637804 |
| 55 | Hyperacusis (HP:0010780) | 2.03501009 |
| 56 | Hemiparesis (HP:0001269) | 2.03089783 |
| 57 | Lissencephaly (HP:0001339) | 2.02214994 |
| 58 | Optic nerve hypoplasia (HP:0000609) | 2.00485778 |
| 59 | Polyphagia (HP:0002591) | 1.99454229 |
| 60 | Abnormality of the nasal septum (HP:0000419) | 1.99394561 |
| 61 | Supranuclear gaze palsy (HP:0000605) | 1.98431465 |
| 62 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.98301207 |
| 63 | Inappropriate behavior (HP:0000719) | 1.98006438 |
| 64 | Urethral obstruction (HP:0000796) | 1.97870300 |
| 65 | Pointed chin (HP:0000307) | 1.95718518 |
| 66 | Atonic seizures (HP:0010819) | 1.93816862 |
| 67 | Impaired smooth pursuit (HP:0007772) | 1.93359446 |
| 68 | Dysmetric saccades (HP:0000641) | 1.92786882 |
| 69 | Epileptiform EEG discharges (HP:0011182) | 1.92101753 |
| 70 | Abnormality of the aortic arch (HP:0012303) | 1.91861623 |
| 71 | Ankle clonus (HP:0011448) | 1.91755712 |
| 72 | Agitation (HP:0000713) | 1.91613538 |
| 73 | Stomach cancer (HP:0012126) | 1.89750627 |
| 74 | Rib fusion (HP:0000902) | 1.88817417 |
| 75 | Exotropia (HP:0000577) | 1.86832911 |
| 76 | Hypochromic microcytic anemia (HP:0004840) | 1.86344431 |
| 77 | Visual hallucinations (HP:0002367) | 1.85023207 |
| 78 | Abnormal hair whorl (HP:0010721) | 1.84859803 |
| 79 | Gait imbalance (HP:0002141) | 1.84794496 |
| 80 | Intellectual disability, severe (HP:0010864) | 1.84523083 |
| 81 | Hypsarrhythmia (HP:0002521) | 1.84245654 |
| 82 | Truncal obesity (HP:0001956) | 1.83902801 |
| 83 | Shawl scrotum (HP:0000049) | 1.83264890 |
| 84 | Insomnia (HP:0100785) | 1.83216441 |
| 85 | Truncal ataxia (HP:0002078) | 1.82853408 |
| 86 | Renovascular hypertension (HP:0100817) | 1.82693382 |
| 87 | Absent frontal sinuses (HP:0002688) | 1.82302337 |
| 88 | EEG with generalized epileptiform discharges (HP:0011198) | 1.82003000 |
| 89 | Poor eye contact (HP:0000817) | 1.81008397 |
| 90 | Inability to walk (HP:0002540) | 1.80975065 |
| 91 | Heterotopia (HP:0002282) | 1.80946675 |
| 92 | Depressed nasal tip (HP:0000437) | 1.79954296 |
| 93 | Flat cornea (HP:0007720) | 1.79799306 |
| 94 | Thin bony cortex (HP:0002753) | 1.78786878 |
| 95 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.77897920 |
| 96 | Prolonged QT interval (HP:0001657) | 1.77801687 |
| 97 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.77046113 |
| 98 | Thick eyebrow (HP:0000574) | 1.76450875 |
| 99 | Abnormality of incisor morphology (HP:0011063) | 1.75263179 |
| 100 | Widely spaced teeth (HP:0000687) | 1.75083695 |
| 101 | Pachygyria (HP:0001302) | 1.75003743 |
| 102 | Syringomyelia (HP:0003396) | 1.74044144 |
| 103 | Spinal cord lesions (HP:0100561) | 1.74044144 |
| 104 | Supernumerary ribs (HP:0005815) | 1.73747783 |
| 105 | Intellectual disability, moderate (HP:0002342) | 1.72106581 |
| 106 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.71869813 |
| 107 | Megalencephaly (HP:0001355) | 1.70989154 |
| 108 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.70928226 |
| 109 | Abnormality of chromosome segregation (HP:0002916) | 1.70001071 |
| 110 | Cystic liver disease (HP:0006706) | 1.69924832 |
| 111 | Abnormality of the parietal bone (HP:0002696) | 1.69847440 |
| 112 | Type II lissencephaly (HP:0007260) | 1.69326508 |
| 113 | Annular pancreas (HP:0001734) | 1.68714151 |
| 114 | Glioma (HP:0009733) | 1.68409059 |
| 115 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.67907933 |
| 116 | Abnormality of the 4th metacarpal (HP:0010012) | 1.67746241 |
| 117 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.66162141 |
| 118 | Absent/shortened dynein arms (HP:0200106) | 1.66162141 |
| 119 | Renal duplication (HP:0000075) | 1.66115167 |
| 120 | Impulsivity (HP:0100710) | 1.65902653 |
| 121 | Anophthalmia (HP:0000528) | 1.65595100 |
| 122 | Sacral dimple (HP:0000960) | 1.65564300 |
| 123 | Impaired social interactions (HP:0000735) | 1.65552317 |
| 124 | Abnormal social behavior (HP:0012433) | 1.65552317 |
| 125 | Hypoplastic ischia (HP:0003175) | 1.64887726 |
| 126 | Mask-like facies (HP:0000298) | 1.64261230 |
| 127 | Vertebral arch anomaly (HP:0008438) | 1.62108960 |
| 128 | Broad palm (HP:0001169) | 1.61356614 |
| 129 | Hypoplasia of the maxilla (HP:0000327) | 1.61254286 |
| 130 | Specific learning disability (HP:0001328) | 1.60819036 |
| 131 | Stereotypic behavior (HP:0000733) | 1.60092654 |
| 132 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.60059813 |
| 133 | Generalized tonic-clonic seizures (HP:0002069) | 1.59786280 |
| 134 | Pendular nystagmus (HP:0012043) | 1.59730829 |
| 135 | Abnormality of salivation (HP:0100755) | 1.59293695 |
| 136 | Gastroesophageal reflux (HP:0002020) | 1.58660599 |
| 137 | Deeply set eye (HP:0000490) | 1.58243694 |
| 138 | Genital tract atresia (HP:0001827) | 1.58232097 |
| 139 | Poor coordination (HP:0002370) | 1.58034415 |
| 140 | Lip pit (HP:0100267) | 1.57991026 |
| 141 | Dysmetria (HP:0001310) | 1.56766962 |
| 142 | Cutaneous finger syndactyly (HP:0010554) | 1.55659841 |
| 143 | Dysdiadochokinesis (HP:0002075) | 1.55003256 |
| 144 | Overriding aorta (HP:0002623) | 1.54173967 |
| 145 | Tented upper lip vermilion (HP:0010804) | 1.54087450 |
| 146 | Abnormality of the right ventricle (HP:0001707) | 1.53902437 |
| 147 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.53853935 |
| 148 | Increased nuchal translucency (HP:0010880) | 1.53080144 |
| 149 | Congenital stationary night blindness (HP:0007642) | 1.52879806 |
| 150 | Lower limb amyotrophy (HP:0007210) | 1.52488823 |
| 151 | Amblyopia (HP:0000646) | 1.52472551 |
| 152 | Tapered finger (HP:0001182) | 1.51539771 |
| 153 | Long clavicles (HP:0000890) | 1.50314282 |
| 154 | Autism (HP:0000717) | 1.50215299 |
| 155 | Shallow orbits (HP:0000586) | 1.49988192 |
| 156 | Spastic gait (HP:0002064) | 1.47936702 |
| 157 | Anosmia (HP:0000458) | 1.46885363 |
| 158 | Hemiplegia (HP:0002301) | 1.46749724 |
| 159 | Blue irides (HP:0000635) | 1.46610679 |
| 160 | Atrial fibrillation (HP:0005110) | 1.46552407 |
| 161 | Hyperventilation (HP:0002883) | 1.45823386 |
| 162 | Primary atrial arrhythmia (HP:0001692) | 1.45628947 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 3.44488074 |
| 2 | NTRK3 | 3.20565566 |
| 3 | MARK1 | 2.89102074 |
| 4 | EPHA4 | 2.68233950 |
| 5 | SIK2 | 2.55183374 |
| 6 | MAP3K4 | 2.50520766 |
| 7 | MUSK | 2.46882917 |
| 8 | FRK | 2.32360123 |
| 9 | BRD4 | 2.12768443 |
| 10 | PRPF4B | 2.02059991 |
| 11 | MAP3K9 | 1.91872388 |
| 12 | NTRK2 | 1.90907368 |
| 13 | CAMK1G | 1.82407432 |
| 14 | NLK | 1.77845059 |
| 15 | CLK1 | 1.70278149 |
| 16 | MAP2K7 | 1.67858269 |
| 17 | DMPK | 1.64622194 |
| 18 | MAPK13 | 1.59618974 |
| 19 | CDK19 | 1.58904888 |
| 20 | WNK3 | 1.53733145 |
| 21 | SGK3 | 1.51599924 |
| 22 | SGK2 | 1.49319187 |
| 23 | PRKD3 | 1.48506759 |
| 24 | MARK2 | 1.48285539 |
| 25 | WNK1 | 1.46204584 |
| 26 | DYRK2 | 1.42881732 |
| 27 | SGK223 | 1.39827743 |
| 28 | SGK494 | 1.39827743 |
| 29 | STK38 | 1.29373665 |
| 30 | TYRO3 | 1.28714102 |
| 31 | UHMK1 | 1.28332026 |
| 32 | CAMKK2 | 1.27526353 |
| 33 | PAK6 | 1.25981089 |
| 34 | FES | 1.22099470 |
| 35 | CASK | 1.22023728 |
| 36 | CAMK1D | 1.18865269 |
| 37 | TNIK | 1.14734438 |
| 38 | ICK | 1.12135265 |
| 39 | INSRR | 1.12131990 |
| 40 | ALK | 1.05891394 |
| 41 | TXK | 1.05010802 |
| 42 | MINK1 | 0.99868229 |
| 43 | SIK3 | 0.99805474 |
| 44 | DYRK1B | 0.99390289 |
| 45 | CDK5 | 0.97177388 |
| 46 | PRKCG | 0.97129105 |
| 47 | CDK9 | 0.96558228 |
| 48 | CAMK4 | 0.95217029 |
| 49 | CDC42BPA | 0.92343451 |
| 50 | PDGFRB | 0.91211930 |
| 51 | PINK1 | 0.90446396 |
| 52 | SGK1 | 0.90174871 |
| 53 | PRKCH | 0.89564167 |
| 54 | CSNK1A1L | 0.88621685 |
| 55 | FGFR3 | 0.88176079 |
| 56 | HIPK2 | 0.88089780 |
| 57 | PHKG1 | 0.87872997 |
| 58 | PHKG2 | 0.87872997 |
| 59 | MAPK7 | 0.86497209 |
| 60 | BMPR1B | 0.86159089 |
| 61 | MKNK2 | 0.85400396 |
| 62 | MAP3K7 | 0.85324450 |
| 63 | DYRK1A | 0.84298682 |
| 64 | MAPK15 | 0.84257186 |
| 65 | DAPK2 | 0.83669738 |
| 66 | PKN1 | 0.83026607 |
| 67 | FGFR2 | 0.81989903 |
| 68 | RPS6KA2 | 0.78941444 |
| 69 | PRKCZ | 0.77182662 |
| 70 | PNCK | 0.75196822 |
| 71 | KSR1 | 0.75018877 |
| 72 | AKT3 | 0.73591123 |
| 73 | ITK | 0.73490906 |
| 74 | TAOK3 | 0.72788794 |
| 75 | EEF2K | 0.71863795 |
| 76 | TNK2 | 0.71224711 |
| 77 | STK11 | 0.71054172 |
| 78 | CAMK1 | 0.70977352 |
| 79 | RIPK1 | 0.70699560 |
| 80 | MAP3K10 | 0.70087669 |
| 81 | OXSR1 | 0.68641133 |
| 82 | MAP3K6 | 0.66541585 |
| 83 | CSNK1G2 | 0.66003310 |
| 84 | PRKD2 | 0.65558685 |
| 85 | RET | 0.64947789 |
| 86 | CAMKK1 | 0.63656924 |
| 87 | NUAK1 | 0.62969518 |
| 88 | PLK2 | 0.62240180 |
| 89 | CDK3 | 0.62040651 |
| 90 | EPHA3 | 0.61244476 |
| 91 | PAK3 | 0.60787041 |
| 92 | MAP2K4 | 0.60114507 |
| 93 | TAOK1 | 0.59592051 |
| 94 | MAPK8 | 0.58595067 |
| 95 | MAPK10 | 0.58510735 |
| 96 | ERBB3 | 0.58114719 |
| 97 | GRK6 | 0.56500254 |
| 98 | CAMK2A | 0.56156949 |
| 99 | GSK3B | 0.55704275 |
| 100 | MAP4K1 | 0.54129360 |
| 101 | MTOR | 0.53718004 |
| 102 | HCK | 0.52791062 |
| 103 | MAP3K13 | 0.52583721 |
| 104 | PDGFRA | 0.51116286 |
| 105 | PRKG1 | 0.50635800 |
| 106 | PRKD1 | 0.50596452 |
| 107 | MAPK14 | 0.50595344 |
| 108 | MAPK12 | 0.48970450 |
| 109 | RPS6KA3 | 0.48796420 |
| 110 | PASK | 0.48611023 |
| 111 | TGFBR2 | 0.48235311 |
| 112 | DYRK3 | 0.47576637 |
| 113 | FYN | 0.47389762 |
| 114 | PTK2B | 0.47300462 |
| 115 | CSNK1D | 0.46969828 |
| 116 | PRKCE | 0.46607207 |
| 117 | ADRBK2 | 0.45400064 |
| 118 | CAMK2B | 0.44493089 |
| 119 | EPHB2 | 0.43717582 |
| 120 | MARK3 | 0.43596273 |
| 121 | OBSCN | 0.43499045 |
| 122 | PRKDC | 0.43421516 |
| 123 | ACVR1B | 0.43183128 |
| 124 | ZAK | 0.42470561 |
| 125 | YES1 | 0.42279806 |
| 126 | PRKCQ | 0.41903989 |
| 127 | FER | 0.41167836 |
| 128 | ERBB2 | 0.40652180 |
| 129 | DDR2 | 0.40492272 |
| 130 | RIPK4 | 0.40095371 |
| 131 | RPS6KC1 | 0.39827676 |
| 132 | RPS6KL1 | 0.39827676 |
| 133 | GRK1 | 0.39032524 |
| 134 | PRKAA1 | 0.38606784 |
| 135 | SYK | 0.34667452 |
| 136 | RPS6KA6 | 0.34570305 |
| 137 | GRK5 | 0.34490975 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.17700045 |
| 2 | Circadian entrainment_Homo sapiens_hsa04713 | 2.11968435 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.07945211 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.97020771 |
| 5 | Morphine addiction_Homo sapiens_hsa05032 | 1.93081495 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 1.90135613 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.83039541 |
| 8 | GABAergic synapse_Homo sapiens_hsa04727 | 1.68164227 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.65310233 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.62679190 |
| 11 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.61752505 |
| 12 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60789966 |
| 13 | Phototransduction_Homo sapiens_hsa04744 | 1.57832274 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.57466821 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.52151599 |
| 16 | Renin secretion_Homo sapiens_hsa04924 | 1.46083462 |
| 17 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.44876429 |
| 18 | Salivary secretion_Homo sapiens_hsa04970 | 1.42813003 |
| 19 | Axon guidance_Homo sapiens_hsa04360 | 1.39888284 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.38254989 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37574474 |
| 22 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.36826311 |
| 23 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.33632582 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.32339598 |
| 25 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.31853661 |
| 26 | Taste transduction_Homo sapiens_hsa04742 | 1.31341351 |
| 27 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.30200296 |
| 28 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.27538678 |
| 29 | Long-term depression_Homo sapiens_hsa04730 | 1.24193207 |
| 30 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.22421728 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.22240062 |
| 32 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.21874428 |
| 33 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.20129316 |
| 34 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.18799667 |
| 35 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.18440952 |
| 36 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.18436424 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.16799583 |
| 38 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.11078987 |
| 39 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.10514367 |
| 40 | Glioma_Homo sapiens_hsa05214 | 1.10025548 |
| 41 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.09333634 |
| 42 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.09244532 |
| 43 | MAPK signaling pathway_Homo sapiens_hsa04010 | 1.07958198 |
| 44 | Endometrial cancer_Homo sapiens_hsa05213 | 1.06494660 |
| 45 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.04868790 |
| 46 | Colorectal cancer_Homo sapiens_hsa05210 | 1.04055749 |
| 47 | Gap junction_Homo sapiens_hsa04540 | 1.01721170 |
| 48 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.00352876 |
| 49 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.99421944 |
| 50 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.98780165 |
| 51 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.98677478 |
| 52 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.97355538 |
| 53 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.94522051 |
| 54 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.94158587 |
| 55 | Melanogenesis_Homo sapiens_hsa04916 | 0.94063392 |
| 56 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.92526378 |
| 57 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.91266403 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.89320779 |
| 59 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.89207508 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.88167026 |
| 61 | Circadian rhythm_Homo sapiens_hsa04710 | 0.88115966 |
| 62 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.87385911 |
| 63 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.86075398 |
| 64 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.85970661 |
| 65 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83093001 |
| 66 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.82663389 |
| 67 | Lysine degradation_Homo sapiens_hsa00310 | 0.82426033 |
| 68 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.82058852 |
| 69 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.80933072 |
| 70 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.80726657 |
| 71 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.80519523 |
| 72 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.80183193 |
| 73 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.78197373 |
| 74 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76490167 |
| 75 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.76235516 |
| 76 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76092151 |
| 77 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.75457783 |
| 78 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.75153713 |
| 79 | Alcoholism_Homo sapiens_hsa05034 | 0.75034173 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.74105780 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.73418790 |
| 82 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.72510102 |
| 83 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.72327475 |
| 84 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.71111258 |
| 85 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.70072221 |
| 86 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.69325315 |
| 87 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.69127969 |
| 88 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.68651256 |
| 89 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.67874640 |
| 90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.67013683 |
| 91 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.66543160 |
| 92 | Viral myocarditis_Homo sapiens_hsa05416 | 0.65343664 |
| 93 | Platelet activation_Homo sapiens_hsa04611 | 0.65259620 |
| 94 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.64391500 |
| 95 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.63562208 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.63033614 |
| 97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.62675607 |
| 98 | Prostate cancer_Homo sapiens_hsa05215 | 0.62329433 |
| 99 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.61505808 |
| 100 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.61389039 |
| 101 | ABC transporters_Homo sapiens_hsa02010 | 0.60987524 |
| 102 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.60433063 |
| 103 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.60423539 |
| 104 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.59909160 |
| 105 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.59883022 |
| 106 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.59804074 |
| 107 | Adherens junction_Homo sapiens_hsa04520 | 0.58425904 |
| 108 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.57541196 |
| 109 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.57496355 |
| 110 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.55822716 |
| 111 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.55508427 |
| 112 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.54262640 |
| 113 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.51795996 |
| 114 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.49186744 |
| 115 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.48773790 |
| 116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.46605521 |
| 117 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.45009726 |
| 118 | Melanoma_Homo sapiens_hsa05218 | 0.44075557 |
| 119 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.43589603 |
| 120 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.43551498 |

