TNS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)5.30014459
2fatty acid transmembrane transport (GO:1902001)5.11930554
3sarcomere organization (GO:0045214)4.71769526
4regulation of sequestering of triglyceride (GO:0010889)4.59422778
5cardiac myofibril assembly (GO:0055003)4.57502592
6tricarboxylic acid cycle (GO:0006099)4.52429265
7amino-acid betaine transport (GO:0015838)4.52231986
8carnitine transport (GO:0015879)4.52231986
9carnitine transmembrane transport (GO:1902603)4.43989636
10lysine catabolic process (GO:0006554)4.31359497
11lysine metabolic process (GO:0006553)4.31359497
12fatty acid beta-oxidation (GO:0006635)4.31309536
13plasma membrane repair (GO:0001778)4.13184962
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.12223052
152-oxoglutarate metabolic process (GO:0006103)4.11109745
16valine metabolic process (GO:0006573)4.10429913
17myofibril assembly (GO:0030239)4.02285617
18quaternary ammonium group transport (GO:0015697)3.96943663
19cellular response to epinephrine stimulus (GO:0071872)3.86496634
20biotin metabolic process (GO:0006768)3.84117372
21tricarboxylic acid metabolic process (GO:0072350)3.79520143
22regulation of fatty acid oxidation (GO:0046320)3.77642760
23low-density lipoprotein particle clearance (GO:0034383)3.71728192
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.70826779
25fatty acid oxidation (GO:0019395)3.70235638
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.68831682
27NADH metabolic process (GO:0006734)3.65086654
28actin-myosin filament sliding (GO:0033275)3.63531646
29muscle filament sliding (GO:0030049)3.63531646
30lipid oxidation (GO:0034440)3.62579941
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.59749944
32fatty acid catabolic process (GO:0009062)3.58950863
33extracellular matrix assembly (GO:0085029)3.58748478
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.57684004
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.55109515
36positive regulation of fatty acid oxidation (GO:0046321)3.54615393
37acetyl-CoA metabolic process (GO:0006084)3.42874811
38regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.39970517
39branched-chain amino acid metabolic process (GO:0009081)3.35579898
40regulation of skeletal muscle contraction (GO:0014819)3.34943373
41cardiac muscle contraction (GO:0060048)3.34800875
42response to epinephrine (GO:0071871)3.33511079
43aspartate family amino acid catabolic process (GO:0009068)3.29728814
44cardiac muscle cell development (GO:0055013)3.29604106
45intracellular lipid transport (GO:0032365)3.22252477
46actomyosin structure organization (GO:0031032)3.20701295
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19836806
48ventricular cardiac muscle cell action potential (GO:0086005)3.19393444
49oxaloacetate metabolic process (GO:0006107)3.18625735
50branched-chain amino acid catabolic process (GO:0009083)3.18542300
51vascular endothelial growth factor signaling pathway (GO:0038084)3.17644157
52cell migration involved in heart development (GO:0060973)3.16696519
53extracellular fibril organization (GO:0043206)3.14623091
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13903759
55regulation of acyl-CoA biosynthetic process (GO:0050812)3.13473040
56cardiac cell development (GO:0055006)3.12472559
57surfactant homeostasis (GO:0043129)3.12403226
58heart trabecula formation (GO:0060347)3.10769564
59actin-mediated cell contraction (GO:0070252)3.09581721
60regulation of fatty acid beta-oxidation (GO:0031998)3.06273982
61protein heterotrimerization (GO:0070208)3.05860553
62regulation of actin filament-based movement (GO:1903115)3.05609234
63short-chain fatty acid metabolic process (GO:0046459)3.04203591
64carnitine metabolic process (GO:0009437)3.02748226
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99867783
66monocarboxylic acid catabolic process (GO:0072329)2.96877331
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96252879
68brown fat cell differentiation (GO:0050873)2.95183926
69regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95106555
70lipid particle organization (GO:0034389)2.91018589
71barbed-end actin filament capping (GO:0051016)2.90989740
72regulation of integrin-mediated signaling pathway (GO:2001044)2.90921571
73creatine metabolic process (GO:0006600)2.90276578
74ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.88102059
75ovulation from ovarian follicle (GO:0001542)2.87285129
76cardiac muscle tissue morphogenesis (GO:0055008)2.86811164
77glomerular filtration (GO:0003094)2.86433163
78fibril organization (GO:0097435)2.86368813
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85733908
80regulation of coenzyme metabolic process (GO:0051196)2.84930982
81regulation of cofactor metabolic process (GO:0051193)2.84930982
82cGMP-mediated signaling (GO:0019934)2.84805521
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83290075
84stress fiber assembly (GO:0043149)2.83200362
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82048206
86succinate metabolic process (GO:0006105)2.81404281
87regulation of p38MAPK cascade (GO:1900744)2.79870735
88renal filtration (GO:0097205)2.79398180
89peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.78844685
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77957094
91response to mercury ion (GO:0046689)2.76932129
92cardiac muscle hypertrophy (GO:0003300)2.74008999
93endocrine hormone secretion (GO:0060986)2.72049848
94regulation of cholesterol storage (GO:0010885)2.69556308
95cell communication involved in cardiac conduction (GO:0086065)2.68114858
96regulation of the force of heart contraction (GO:0002026)2.67536307
97triglyceride catabolic process (GO:0019433)2.66916492
98regulation of relaxation of muscle (GO:1901077)2.65059678
99muscle tissue morphogenesis (GO:0060415)2.65005316
100chemical homeostasis within a tissue (GO:0048875)2.64396749
101positive regulation of receptor recycling (GO:0001921)2.63597043
102striated muscle hypertrophy (GO:0014897)2.62511865
103amino-acid betaine metabolic process (GO:0006577)2.62263570
104apoptotic cell clearance (GO:0043277)2.59794686
105actin filament-based movement (GO:0030048)2.59501128
106adult heart development (GO:0007512)2.58806999
107negative regulation of smooth muscle cell migration (GO:0014912)2.58777336
108regulation of cardioblast differentiation (GO:0051890)2.56711278
109basement membrane organization (GO:0071711)2.56039437
110regulation of striated muscle contraction (GO:0006942)2.55383543
111keratan sulfate catabolic process (GO:0042340)2.52432065
112acylglycerol catabolic process (GO:0046464)2.52420561
113neutral lipid catabolic process (GO:0046461)2.52420561
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.52310899
115alpha-linolenic acid metabolic process (GO:0036109)2.51976008
116striated muscle contraction (GO:0006941)2.51833528
117negative regulation of cardiac muscle tissue growth (GO:0055022)2.49419407
118negative regulation of heart growth (GO:0061117)2.49419407
119long-chain fatty acid transport (GO:0015909)2.49096482
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48487730
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48233161
122glomerular basement membrane development (GO:0032836)2.48148938
123positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46595662
124atrioventricular valve morphogenesis (GO:0003181)2.46404558
125adherens junction assembly (GO:0034333)2.44834273
126endothelial cell chemotaxis (GO:0035767)2.44705048
127cell-substrate adherens junction assembly (GO:0007045)2.44137442
128focal adhesion assembly (GO:0048041)2.44137442
129cell volume homeostasis (GO:0006884)2.43565399
130insulin-like growth factor receptor signaling pathway (GO:0048009)2.42759907
131polyol transport (GO:0015791)2.42206774
132cellular response to monoamine stimulus (GO:0071868)2.41899871
133cellular response to catecholamine stimulus (GO:0071870)2.41899871
134negative regulation of protein localization to cell surface (GO:2000009)2.40090173
135muscle hypertrophy (GO:0014896)2.39368941
136endothelium development (GO:0003158)2.36979283
137metanephric nephron epithelium development (GO:0072243)2.36642544
138response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.32796274
139venous blood vessel morphogenesis (GO:0048845)2.31629163
140negative regulation of complement activation (GO:0045916)2.31379245
141transcytosis (GO:0045056)2.30080917
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.29784969
143import into cell (GO:0098657)2.26806573
144positive regulation of cholesterol efflux (GO:0010875)2.24583291
145metanephric tubule development (GO:0072170)2.23135244
146metanephric nephron tubule development (GO:0072234)2.23135244
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22775408
148sarcoplasmic reticulum calcium ion transport (GO:0070296)2.22613030
149regulation of membrane protein ectodomain proteolysis (GO:0051043)2.20136363
150negative regulation of granulocyte differentiation (GO:0030853)2.19669124
151response to catecholamine (GO:0071869)2.19526985
152response to monoamine (GO:0071867)2.19526985
153muscle contraction (GO:0006936)2.19525647
154* cell-substrate junction assembly (GO:0007044)2.19488524
155negative regulation of fatty acid transport (GO:2000192)2.19094816
156positive regulation of lipid storage (GO:0010884)2.19072222
157activation of protein kinase A activity (GO:0034199)2.18531164
158positive regulation of glucose import (GO:0046326)2.17637718
159regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.16201480
160positive regulation of endothelial cell apoptotic process (GO:2000353)2.15896761
161negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.14759488
162metanephric epithelium development (GO:0072207)2.14515526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.30694994
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.66062958
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.60592621
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17845891
5CLOCK_20551151_ChIP-Seq_293T_Human3.13777931
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.86199916
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.81916414
8* EP300_21415370_ChIP-Seq_HL-1_Mouse2.70886671
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.63326078
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57661364
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.45195465
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.45195465
13* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.26675174
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.25962786
15ZNF263_19887448_ChIP-Seq_K562_Human2.05351425
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.03637341
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.99170732
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95819623
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.90799996
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.88028018
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87192675
22* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75919997
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.75719160
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72933580
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70580586
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65543273
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62963400
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60181158
29GATA1_22025678_ChIP-Seq_K562_Human1.56235851
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53772081
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44838277
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42298776
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39562474
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.39021741
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37619813
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.37458130
37CJUN_26792858_Chip-Seq_BT549_Human1.36890593
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36005097
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35481703
40* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34148910
41* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31389607
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.30217248
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.29200223
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25736483
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25656863
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25175311
47* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24890610
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24532571
49LXR_22292898_ChIP-Seq_THP-1_Human1.23993421
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23515686
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23515686
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22787855
53RACK7_27058665_Chip-Seq_MCF-7_Human1.22247976
54* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21381873
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20720335
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19882523
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18903379
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17674184
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.13160612
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11609674
61GATA1_19941826_ChIP-Seq_K562_Human1.10317344
62EZH2_22144423_ChIP-Seq_EOC_Human1.09752960
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04267266
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03022625
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02936728
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02198238
67* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02114475
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02025443
69* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99267852
70* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98967091
71* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98686862
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98442620
73EED_16625203_ChIP-ChIP_MESCs_Mouse0.97696769
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97275608
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97172901
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97037535
77TP53_16413492_ChIP-PET_HCT116_Human0.96532018
78KDM2B_26808549_Chip-Seq_K562_Human0.96192243
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95336691
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95122837
81GATA2_19941826_ChIP-Seq_K562_Human0.93694201
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93006171
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92728853
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92204802
85NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92011454
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.91734461
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.91631853
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91192165
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91192165
90P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91112975
91KDM2B_26808549_Chip-Seq_DND41_Human0.90991681
92* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90630558
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90484280
94* RNF2_27304074_Chip-Seq_ESCs_Mouse0.89990329
95* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89698489
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89385398
97* TP63_22573176_ChIP-Seq_HFKS_Human0.88866666
98VDR_24787735_ChIP-Seq_THP-1_Human0.88739436
99* AHR_22903824_ChIP-Seq_MCF-7_Human0.88673566
100* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88661046
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.88347878
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88097455
103SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88089474
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87550374
105TCF7_22412390_ChIP-Seq_EML_Mouse0.87178528
106* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87156182
107SOX2_20726797_ChIP-Seq_SW620_Human0.86927291
108ATF3_27146783_Chip-Seq_COLON_Human0.86615945
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86295636
110DROSHA_22980978_ChIP-Seq_HELA_Human0.85862931
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85027593
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84917264
113* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84334140
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84286077
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83903226
116* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83771835
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83458570
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83142258
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83094704
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82871819
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82409774
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.81867953
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.81800357
124* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81494960
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81050545
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80879652
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80679572
128* ARNT_22903824_ChIP-Seq_MCF-7_Human0.80195036
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.80089461
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79805119
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78947280
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78419590
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77879914
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77751573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.97551511
2MP0004084_abnormal_cardiac_muscle3.83518730
3MP0005670_abnormal_white_adipose3.66044785
4MP0000751_myopathy3.60416529
5MP0003646_muscle_fatigue3.26910009
6MP0004130_abnormal_muscle_cell3.08370662
7MP0008438_abnormal_cutaneous_collagen3.01220055
8MP0004036_abnormal_muscle_relaxation2.89849528
9MP0004215_abnormal_myocardial_fiber2.88132353
10MP0005666_abnormal_adipose_tissue2.75652929
11MP0005330_cardiomyopathy2.71364120
12MP0000749_muscle_degeneration2.44213281
13MP0008775_abnormal_heart_ventricle2.29609011
14MP0004087_abnormal_muscle_fiber2.22256630
15MP0003705_abnormal_hypodermis_morpholog2.20977975
16MP0002972_abnormal_cardiac_muscle2.17627208
17MP0001958_emphysema2.16750716
18MP0010368_abnormal_lymphatic_system2.15241790
19MP0006138_congestive_heart_failure2.15028762
20MP0005275_abnormal_skin_tensile2.12420118
21MP0000750_abnormal_muscle_regeneration2.08627171
22MP0001544_abnormal_cardiovascular_syste2.04932531
23MP0005385_cardiovascular_system_phenoty2.04932531
24MP0004185_abnormal_adipocyte_glucose2.04353952
25MP0005375_adipose_tissue_phenotype2.01881469
26MP0005620_abnormal_muscle_contractility2.01036030
27MP0004272_abnormal_basement_membrane1.96463465
28MP0010630_abnormal_cardiac_muscle1.87309708
29MP0003828_pulmonary_edema1.85155603
30MP0005360_urolithiasis1.83792641
31MP0003279_aneurysm1.70874784
32MP0004484_altered_response_of1.63069975
33MP0003091_abnormal_cell_migration1.60409387
34MP0003191_abnormal_cellular_cholesterol1.54089081
35MP0003137_abnormal_impulse_conducting1.51829031
36MP0001879_abnormal_lymphatic_vessel1.51537610
37MP0002269_muscular_atrophy1.51210189
38MP0002106_abnormal_muscle_physiology1.51169038
39MP0000013_abnormal_adipose_tissue1.50328307
40MP0002139_abnormal_hepatobiliary_system1.40248843
41MP0000759_abnormal_skeletal_muscle1.37823903
42MP0005332_abnormal_amino_acid1.37666130
43MP0002971_abnormal_brown_adipose1.37158314
44MP0000747_muscle_weakness1.36494080
45MP0000343_altered_response_to1.34825136
46MP0000003_abnormal_adipose_tissue1.33608063
47MP0008004_abnormal_stomach_pH1.30757886
48MP0005369_muscle_phenotype1.30545108
49MP0005023_abnormal_wound_healing1.28976766
50MP0004085_abnormal_heartbeat1.27509447
51MP0009643_abnormal_urine_homeostasis1.25831150
52MP0004043_abnormal_pH_regulation1.25438032
53MP0001756_abnormal_urination1.24017466
54MP0005164_abnormal_response_to1.22719101
55MP0010329_abnormal_lipoprotein_level1.22403815
56MP0002933_joint_inflammation1.21341367
57* MP0003566_abnormal_cell_adhesion1.20411641
58MP0005365_abnormal_bile_salt1.20253752
59MP0003950_abnormal_plasma_membrane1.17422618
60MP0002138_abnormal_hepatobiliary_system1.17191090
61MP0001542_abnormal_bone_strength1.13982688
62MP0000230_abnormal_systemic_arterial1.12935580
63MP0006036_abnormal_mitochondrial_physio1.10737925
64MP0008961_abnormal_basal_metabolism1.10482809
65MP0002118_abnormal_lipid_homeostasis1.10336647
66MP0003252_abnormal_bile_duct1.09712098
67MP0003221_abnormal_cardiomyocyte_apopto1.09595934
68MP0003045_fibrosis1.09423791
69MP0003690_abnormal_glial_cell1.07855376
70MP0005167_abnormal_blood-brain_barrier1.06204528
71MP0005409_darkened_coat_color1.05610727
72MP0002108_abnormal_muscle_morphology1.05446495
73MP0004233_abnormal_muscle_weight1.05371420
74MP0009115_abnormal_fat_cell1.04450592
75MP0005388_respiratory_system_phenotype1.02395663
76MP0005319_abnormal_enzyme/_coenzyme1.02125465
77MP0002332_abnormal_exercise_endurance1.00521312
78MP0005165_increased_susceptibility_to1.00201517
79MP0002998_abnormal_bone_remodeling0.99295472
80MP0004145_abnormal_muscle_electrophysio0.98705969
81MP0005503_abnormal_tendon_morphology0.98238959
82MP0000767_abnormal_smooth_muscle0.97614061
83MP0002295_abnormal_pulmonary_circulatio0.96639167
84MP0008875_abnormal_xenobiotic_pharmacok0.95897360
85MP0005623_abnormal_meninges_morphology0.95304315
86MP0001765_abnormal_ion_homeostasis0.93833379
87MP0005334_abnormal_fat_pad0.92714808
88MP0002896_abnormal_bone_mineralization0.90638630
89MP0005508_abnormal_skeleton_morphology0.88805812
90MP0000266_abnormal_heart_morphology0.88778661
91MP0004510_myositis0.88163928
92MP0002060_abnormal_skin_morphology0.86987596
93MP0002168_other_aberrant_phenotype0.86161740
94* MP0002128_abnormal_blood_circulation0.85440329
95MP0003656_abnormal_erythrocyte_physiolo0.85283101
96MP0000733_abnormal_muscle_development0.84936410
97MP0003879_abnormal_hair_cell0.83234645
98MP0002127_abnormal_cardiovascular_syste0.83161801
99MP0004883_abnormal_blood_vessel0.82634275
100MP0005085_abnormal_gallbladder_physiolo0.82242408
101MP0003300_gastrointestinal_ulcer0.81945772
102MP0001614_abnormal_blood_vessel0.78841599
103MP0005535_abnormal_body_temperature0.78205744
104MP0004782_abnormal_surfactant_physiolog0.77968182
105MP0003303_peritoneal_inflammation0.77947229
106MP0003868_abnormal_feces_composition0.76706484
107MP0003959_abnormal_lean_body0.76701430
108MP0001661_extended_life_span0.75074768
109MP0005257_abnormal_intraocular_pressure0.74893594
110MP0005584_abnormal_enzyme/coenzyme_acti0.74058423
111MP0009384_cardiac_valve_regurgitation0.73887720
112MP0005595_abnormal_vascular_smooth0.73158301
113* MP0002136_abnormal_kidney_physiology0.72398921
114MP0009780_abnormal_chondrocyte_physiolo0.71217085
115MP0000609_abnormal_liver_physiology0.71066554
116MP0005058_abnormal_lysosome_morphology0.70949543
117MP0002970_abnormal_white_adipose0.69171053
118MP0009840_abnormal_foam_cell0.68440216
119MP0003195_calcinosis0.67716060
120MP0003075_altered_response_to0.66101310
121MP0000249_abnormal_blood_vessel0.66072310
122MP0003567_abnormal_fetal_cardiomyocyte0.65065342
123MP0004019_abnormal_vitamin_homeostasis0.64814236
124MP0003724_increased_susceptibility_to0.64440937
125MP0002078_abnormal_glucose_homeostasis0.64135889
126MP0002133_abnormal_respiratory_system0.63880127

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.45856684
2Muscle fiber splitting (HP:0003555)5.13928079
3Ventricular tachycardia (HP:0004756)4.60537005
4Increased connective tissue (HP:0009025)4.39246907
5Right ventricular cardiomyopathy (HP:0011663)4.37901647
6Hyporeflexia of lower limbs (HP:0002600)4.30790278
7Myoglobinuria (HP:0002913)3.98217700
8Lipoatrophy (HP:0100578)3.94917063
9Atrial fibrillation (HP:0005110)3.80656573
10Exercise-induced myalgia (HP:0003738)3.76706732
11Calf muscle hypertrophy (HP:0008981)3.72695404
12Primary atrial arrhythmia (HP:0001692)3.49894901
13Difficulty running (HP:0009046)3.48857199
14Exercise-induced muscle cramps (HP:0003710)3.48092382
15Abnormality of the calf musculature (HP:0001430)3.46650689
16Hyperglycinuria (HP:0003108)3.38707282
17Supraventricular arrhythmia (HP:0005115)3.34809015
18Supraventricular tachycardia (HP:0004755)3.31905372
19Muscle hypertrophy of the lower extremities (HP:0008968)3.30475904
20Broad metatarsal (HP:0001783)3.29546109
21Ketoacidosis (HP:0001993)3.24555403
22Asymmetric septal hypertrophy (HP:0001670)3.22041568
23Abnormality of fatty-acid metabolism (HP:0004359)3.19706592
24Complement deficiency (HP:0004431)3.11452296
25Dilated cardiomyopathy (HP:0001644)3.09133420
26Palpitations (HP:0001962)2.99905117
27Rhabdomyolysis (HP:0003201)2.93934377
28Abnormality of the left ventricular outflow tract (HP:0011103)2.92691789
29Subaortic stenosis (HP:0001682)2.92691789
30Syncope (HP:0001279)2.92682488
31Vascular tortuosity (HP:0004948)2.91360694
32Type 1 muscle fiber predominance (HP:0003803)2.90513925
33Bundle branch block (HP:0011710)2.87514757
34Ketosis (HP:0001946)2.84604580
35Increased variability in muscle fiber diameter (HP:0003557)2.84369125
36EMG: myopathic abnormalities (HP:0003458)2.77376482
37Hypoglycemic coma (HP:0001325)2.74941469
38Atrioventricular block (HP:0001678)2.73504053
39Abnormality of complement system (HP:0005339)2.72512554
40Prolonged QT interval (HP:0001657)2.72325649
41Cerebral aneurysm (HP:0004944)2.71942603
42Abnormality of glycine metabolism (HP:0010895)2.71328850
43Abnormality of serine family amino acid metabolism (HP:0010894)2.71328850
44Gout (HP:0001997)2.66425786
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60656486
46Systemic lupus erythematosus (HP:0002725)2.60551742
47Wormian bones (HP:0002645)2.59759910
48Ventricular arrhythmia (HP:0004308)2.58619320
49Facial diplegia (HP:0001349)2.58396652
50Arterial tortuosity (HP:0005116)2.57718837
51Myotonia (HP:0002486)2.56172724
52Lymphangioma (HP:0100764)2.54754948
53Neck muscle weakness (HP:0000467)2.54082390
54Shallow orbits (HP:0000586)2.53979476
55Muscle fiber inclusion bodies (HP:0100299)2.53801881
56Difficulty climbing stairs (HP:0003551)2.52602219
57Dicarboxylic aciduria (HP:0003215)2.52254492
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52254492
59Hyperactive renin-angiotensin system (HP:0000841)2.51009872
60Aortic aneurysm (HP:0004942)2.50241942
61Round ear (HP:0100830)2.50027647
62Heart block (HP:0012722)2.49838263
63Abnormality of skeletal muscle fiber size (HP:0012084)2.49745304
64Interstitial pulmonary disease (HP:0006530)2.46908427
65Dilatation of the ascending aorta (HP:0005111)2.45385043
66Abnormal atrioventricular conduction (HP:0005150)2.44244464
67Polycythemia (HP:0001901)2.43927765
68Nemaline bodies (HP:0003798)2.43659308
69Mitral valve prolapse (HP:0001634)2.43158899
70Obstructive sleep apnea (HP:0002870)2.43082536
71Soft skin (HP:0000977)2.37015449
72Osteolytic defects of the hand bones (HP:0009699)2.36120868
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.36120868
74Distal lower limb amyotrophy (HP:0008944)2.35036854
75Aortic regurgitation (HP:0001659)2.33995115
76Overgrowth (HP:0001548)2.32407099
77Hyperammonemia (HP:0001987)2.30364670
78Ankle contracture (HP:0006466)2.29036079
79Protrusio acetabuli (HP:0003179)2.28705053
80Hypokalemic alkalosis (HP:0001949)2.27985728
81Aortic dissection (HP:0002647)2.26532403
82Premature rupture of membranes (HP:0001788)2.24414029
83Generalized aminoaciduria (HP:0002909)2.22907514
84Acanthosis nigricans (HP:0000956)2.21478961
85Spinal rigidity (HP:0003306)2.17934857
86Distal lower limb muscle weakness (HP:0009053)2.16805880
87Hyperuricemia (HP:0002149)2.16538319
88Increased purine levels (HP:0004368)2.16538319
89Aneurysm (HP:0002617)2.16132983
90Striae distensae (HP:0001065)2.14577420
91Proximal tubulopathy (HP:0000114)2.14200098
92Cervical subluxation (HP:0003308)2.13783157
93Mildly elevated creatine phosphokinase (HP:0008180)2.12572830
94Myocardial infarction (HP:0001658)2.10166405
95Oligomenorrhea (HP:0000876)2.08486656
96Generalized muscle weakness (HP:0003324)2.08471193
97Abnormality of proline metabolism (HP:0010907)2.08208300
98Hydroxyprolinuria (HP:0003080)2.08208300
99Ventricular fibrillation (HP:0001663)2.06686576
100Skin nodule (HP:0200036)2.06493678
101Scapular winging (HP:0003691)2.06239012
102Abnormality of chloride homeostasis (HP:0011422)2.05870494
103Hypoplasia of the iris (HP:0007676)2.01847232
104Bladder diverticulum (HP:0000015)2.01195097
105Testicular atrophy (HP:0000029)2.00695358
106Muscle stiffness (HP:0003552)2.00225650
107Abnormality of purine metabolism (HP:0004352)1.98102773
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98094649
109Mitral stenosis (HP:0001718)1.97369591
110Centrally nucleated skeletal muscle fibers (HP:0003687)1.97340476
111Glomerulonephritis (HP:0000099)1.96281167
112Wrist flexion contracture (HP:0001239)1.95204526
113Increased circulating renin level (HP:0000848)1.94696900
114Persistence of primary teeth (HP:0006335)1.92686220
115Bone cyst (HP:0012062)1.90667331
116Visceral angiomatosis (HP:0100761)1.90609440
117Long toe (HP:0010511)1.89724133
118Neoplasm of the heart (HP:0100544)1.89525761
119Hip contracture (HP:0003273)1.88601741
120Conjunctival hamartoma (HP:0100780)1.88419939
121Foot dorsiflexor weakness (HP:0009027)1.88329804
122Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88213042
123Slender build (HP:0001533)1.88161086
124Neonatal death (HP:0003811)1.87279445
125Ulnar deviation of the wrist (HP:0003049)1.86084119
126Hematochezia (HP:0002573)1.85910564
127Vertebral compression fractures (HP:0002953)1.85576015
128Bradycardia (HP:0001662)1.84652020
129Hemorrhage of the eye (HP:0011885)1.84434786
130Abnormality of the foot musculature (HP:0001436)1.84242438
131Mitral regurgitation (HP:0001653)1.83924075
132Esophageal varix (HP:0002040)1.83798331
133Pulmonary artery stenosis (HP:0004415)1.83556300
134Increased muscle lipid content (HP:0009058)1.83408500
135Fragile skin (HP:0001030)1.82304615
136Metabolic alkalosis (HP:0200114)1.81768267
137Joint laxity (HP:0001388)1.81467780
138Hypoalphalipoproteinemia (HP:0003233)1.79578492
139Nausea (HP:0002018)1.78438899
140Stroke (HP:0001297)1.78156804
141Abnormal urine output (HP:0012590)1.77540992
142Hypertriglyceridemia (HP:0002155)1.77129240
143Peritonitis (HP:0002586)1.76877978
144Bulbar palsy (HP:0001283)1.76406835
145Spontaneous hematomas (HP:0007420)1.76282121
146Blue sclerae (HP:0000592)1.76279010
147Limited hip movement (HP:0008800)1.75952490
148Hyperaldosteronism (HP:0000859)1.74854739
149Hemangiomatosis (HP:0007461)1.73990131
150Limb-girdle muscle atrophy (HP:0003797)1.73112011
151Abnormal EKG (HP:0003115)1.72489085
152Hyperkalemia (HP:0002153)1.71509834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.32480242
2TRIB33.94154556
3MYLK3.30621144
4TIE13.22234794
5LMTK23.01414891
6PDK42.87558030
7PDK32.87558030
8BCKDK2.85970559
9WNK42.58475693
10PKN22.22668674
11DMPK2.22266541
12PHKG22.19714038
13PHKG12.19714038
14TGFBR22.17318881
15RIPK12.12279516
16CAMK1D2.10286349
17AKT32.07527530
18SIK12.05783920
19PDK22.03798724
20OBSCN1.97278043
21ERN11.87282706
22CAMK1G1.67909538
23MAP3K61.62321358
24PDGFRA1.61808885
25PIK3CA1.53399471
26PRPF4B1.37541597
27LATS11.31501823
28EPHB11.31061160
29EPHB21.16903972
30FGFR41.16288169
31STK391.15139170
32PRKAA21.11732016
33INSRR1.10379451
34MAPK71.09594591
35PRKD11.07999883
36PINK11.07149961
37SGK21.06498095
38PTK2B1.02660607
39KDR1.01855146
40MAP2K31.01338437
41STK38L1.00903840
42MAP3K71.00248505
43WNK31.00235872
44OXSR10.98652980
45RPS6KA20.97963834
46NEK10.96784196
47MAPKAPK30.96736218
48PTK60.95924010
49MAPK40.91607155
50PAK30.89825333
51FER0.89791808
52WNK10.89341924
53ILK0.88850607
54MAP3K30.88208426
55NLK0.87364462
56LRRK20.84978758
57SGK4940.84866527
58SGK2230.84866527
59PRKAA10.81465246
60MST1R0.81435323
61ROCK10.81075071
62DDR20.80933486
63STK380.80896806
64BLK0.80263732
65KIT0.79378097
66HIPK20.78973001
67MAPK120.75064192
68NEK90.73431183
69PDPK10.72991771
70FGFR20.71129180
71TRPM70.69318738
72ZAP700.68831322
73TESK10.68062502
74LATS20.67963940
75PAK20.66769088
76FGFR30.66715440
77ICK0.65700631
78CDK120.65033769
79MAP3K130.64781498
80STK240.64404989
81PRKD30.64127163
82MTOR0.62799372
83PDGFRB0.61197623
84PRKCH0.59382045
85JAK10.59007504
86CDC42BPA0.58925401
87EPHA30.56734028
88MET0.55253494
89SGK30.54993040
90MAP3K10.54274403
91FLT30.53804191
92CSK0.53202529
93PIK3CG0.51890846
94RET0.51191443
95PTK20.50442388
96TYK20.49039902
97ABL20.48865095
98PAK40.48581703
99DAPK30.48196505
100GSK3A0.46156075
101MOS0.43956897
102TAOK10.43881352
103PRKG20.42354609
104PDK10.41834034
105GRK50.41795233
106MUSK0.40975126
107CAMK40.40718462
108TGFBR10.40571993
109TAOK20.40462414
110CAMK2D0.39200262
111MAP2K10.38594846
112PRKACG0.37979013
113NTRK10.37892110
114MAPK30.36864034
115CAMK2G0.36228461
116PRKG10.35976212
117CAMK10.35970328
118PRKD20.35818690
119JAK20.35773849
120MAPK150.35760103
121KSR20.35576060
122BMX0.35124989
123EEF2K0.34973952
124ROCK20.33630877
125RPS6KL10.32381032
126RPS6KC10.32381032
127GRK70.31675119
128MAP3K50.30915740
129MARK20.28859563
130MAPK110.27908462
131RPS6KA60.27859667

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.27919512
2Propanoate metabolism_Homo sapiens_hsa006403.74943033
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.55046104
4Fatty acid degradation_Homo sapiens_hsa000713.28337443
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.04330472
6Fatty acid metabolism_Homo sapiens_hsa012122.79569247
7PPAR signaling pathway_Homo sapiens_hsa033202.57387634
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20923542
9Pyruvate metabolism_Homo sapiens_hsa006202.12256519
10Dilated cardiomyopathy_Homo sapiens_hsa054142.11708185
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09573104
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09150891
13Carbon metabolism_Homo sapiens_hsa012002.02165629
14Butanoate metabolism_Homo sapiens_hsa006501.86086150
15Fatty acid biosynthesis_Homo sapiens_hsa000611.77721057
16Tryptophan metabolism_Homo sapiens_hsa003801.71410785
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60377798
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59577211
19Malaria_Homo sapiens_hsa051441.58395477
20Cardiac muscle contraction_Homo sapiens_hsa042601.58193588
21beta-Alanine metabolism_Homo sapiens_hsa004101.48275272
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47560085
23ECM-receptor interaction_Homo sapiens_hsa045121.41717899
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.38100647
25Peroxisome_Homo sapiens_hsa041461.34733654
26Arginine biosynthesis_Homo sapiens_hsa002201.26638778
27Nitrogen metabolism_Homo sapiens_hsa009101.24946531
28Insulin resistance_Homo sapiens_hsa049311.24358874
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21872789
30Glycerolipid metabolism_Homo sapiens_hsa005611.21097809
31Histidine metabolism_Homo sapiens_hsa003401.19773379
32Circadian rhythm_Homo sapiens_hsa047101.19171842
33Lysine degradation_Homo sapiens_hsa003101.18045620
34Focal adhesion_Homo sapiens_hsa045101.16906987
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10582658
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10488202
37Fatty acid elongation_Homo sapiens_hsa000621.07319580
38Starch and sucrose metabolism_Homo sapiens_hsa005001.04838251
39AMPK signaling pathway_Homo sapiens_hsa041521.04477891
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01642177
41Protein digestion and absorption_Homo sapiens_hsa049741.01583780
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.01517454
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99947299
44Notch signaling pathway_Homo sapiens_hsa043300.99094739
45Bile secretion_Homo sapiens_hsa049760.97765635
46Caffeine metabolism_Homo sapiens_hsa002320.97255991
47Viral myocarditis_Homo sapiens_hsa054160.94302516
48Oxytocin signaling pathway_Homo sapiens_hsa049210.93979710
49GnRH signaling pathway_Homo sapiens_hsa049120.92478075
50Pertussis_Homo sapiens_hsa051330.90136783
51Prion diseases_Homo sapiens_hsa050200.89985222
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89211436
53Other glycan degradation_Homo sapiens_hsa005110.87331069
54Glucagon signaling pathway_Homo sapiens_hsa049220.85568582
55Insulin signaling pathway_Homo sapiens_hsa049100.85428973
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83945707
57Phenylalanine metabolism_Homo sapiens_hsa003600.83147264
58Biosynthesis of amino acids_Homo sapiens_hsa012300.81831468
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81663026
60Renal cell carcinoma_Homo sapiens_hsa052110.76900280
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.75763791
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74931835
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74133230
64Fat digestion and absorption_Homo sapiens_hsa049750.73612766
65Amoebiasis_Homo sapiens_hsa051460.71637026
66Complement and coagulation cascades_Homo sapiens_hsa046100.67776434
67Acute myeloid leukemia_Homo sapiens_hsa052210.67697990
68Osteoclast differentiation_Homo sapiens_hsa043800.66343715
69Estrogen signaling pathway_Homo sapiens_hsa049150.65433656
70FoxO signaling pathway_Homo sapiens_hsa040680.65278737
71mTOR signaling pathway_Homo sapiens_hsa041500.64998020
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64649652
73Gap junction_Homo sapiens_hsa045400.63797177
74Adherens junction_Homo sapiens_hsa045200.62887164
75VEGF signaling pathway_Homo sapiens_hsa043700.62830921
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62801101
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61906562
78Calcium signaling pathway_Homo sapiens_hsa040200.61289990
79Chronic myeloid leukemia_Homo sapiens_hsa052200.59094808
80Pancreatic secretion_Homo sapiens_hsa049720.58781686
81Rap1 signaling pathway_Homo sapiens_hsa040150.58429910
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57699433
83Parkinsons disease_Homo sapiens_hsa050120.57608086
84ABC transporters_Homo sapiens_hsa020100.56608566
85TNF signaling pathway_Homo sapiens_hsa046680.55175600
86Choline metabolism in cancer_Homo sapiens_hsa052310.54324429
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53703157
88Tyrosine metabolism_Homo sapiens_hsa003500.53626422
89Arginine and proline metabolism_Homo sapiens_hsa003300.53612202
90Pancreatic cancer_Homo sapiens_hsa052120.53066710
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53012958
92Renin secretion_Homo sapiens_hsa049240.52299813
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51291460
94Salivary secretion_Homo sapiens_hsa049700.51087015
95Proteoglycans in cancer_Homo sapiens_hsa052050.50860684
96Long-term potentiation_Homo sapiens_hsa047200.50796886
97Oxidative phosphorylation_Homo sapiens_hsa001900.50321572
98Glioma_Homo sapiens_hsa052140.49868237
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.49556993
100MAPK signaling pathway_Homo sapiens_hsa040100.49161473
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.48434637
102Prolactin signaling pathway_Homo sapiens_hsa049170.47713746
103Tight junction_Homo sapiens_hsa045300.47570143
104Prostate cancer_Homo sapiens_hsa052150.47336581
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46475440
106Insulin secretion_Homo sapiens_hsa049110.46041130
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.45960613
108Pathways in cancer_Homo sapiens_hsa052000.45929663
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.45717713
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.45472463
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.45342559
112Melanogenesis_Homo sapiens_hsa049160.44808560
113HIF-1 signaling pathway_Homo sapiens_hsa040660.44773709
114MicroRNAs in cancer_Homo sapiens_hsa052060.44718373
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44649891
116Circadian entrainment_Homo sapiens_hsa047130.43578938
117Mineral absorption_Homo sapiens_hsa049780.43511026
118Alzheimers disease_Homo sapiens_hsa050100.42827773
119Small cell lung cancer_Homo sapiens_hsa052220.41318312
120Fructose and mannose metabolism_Homo sapiens_hsa000510.38054127
121Gastric acid secretion_Homo sapiens_hsa049710.37906630
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36920865
123Staphylococcus aureus infection_Homo sapiens_hsa051500.34714040
124Sulfur metabolism_Homo sapiens_hsa009200.34577990
125Type II diabetes mellitus_Homo sapiens_hsa049300.32713192
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31356854
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30690068
128Ovarian steroidogenesis_Homo sapiens_hsa049130.30541405
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30520604
130Platelet activation_Homo sapiens_hsa046110.30184215
131Chemical carcinogenesis_Homo sapiens_hsa052040.30176888
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29537969
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29197671
134Glutathione metabolism_Homo sapiens_hsa004800.25806235
135Vitamin digestion and absorption_Homo sapiens_hsa049770.25642770
136Pentose phosphate pathway_Homo sapiens_hsa000300.25287951
137Renin-angiotensin system_Homo sapiens_hsa046140.24986468
138Thyroid hormone synthesis_Homo sapiens_hsa049180.24761086
139Dorso-ventral axis formation_Homo sapiens_hsa043200.24502174
140cAMP signaling pathway_Homo sapiens_hsa040240.24500207
141Toxoplasmosis_Homo sapiens_hsa051450.23493695
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22834445
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.19366501
144Lysosome_Homo sapiens_hsa041420.18927715

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