TNXA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1C21-steroid hormone biosynthetic process (GO:0006700)9.49010805
2glucocorticoid biosynthetic process (GO:0006704)8.03698694
3androgen biosynthetic process (GO:0006702)7.24006024
4glucocorticoid metabolic process (GO:0008211)7.06261407
5cellular response to gonadotropin stimulus (GO:0071371)6.54640025
6positive regulation of vascular permeability (GO:0043117)6.51284162
7tooth mineralization (GO:0034505)6.48313926
8drinking behavior (GO:0042756)6.14182043
9detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.98947568
10C21-steroid hormone metabolic process (GO:0008207)5.94084326
11negative regulation of digestive system process (GO:0060457)5.89856647
12positive regulation of hormone biosynthetic process (GO:0046886)5.86361182
13cellular response to toxic substance (GO:0097237)5.79480782
14response to methylmercury (GO:0051597)5.53909199
15cellular response to cadmium ion (GO:0071276)5.52463720
16Leydig cell differentiation (GO:0033327)5.44070402
17positive regulation of protein sumoylation (GO:0033235)5.21212004
18estrogen biosynthetic process (GO:0006703)5.19732158
19negative regulation of T-helper cell differentiation (GO:0045623)5.07804475
20negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.07804475
21cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.04612592
22short-term memory (GO:0007614)4.92443103
23negative regulation of cell size (GO:0045792)4.90129797
24negative regulation of cytosolic calcium ion concentration (GO:0051481)4.83777031
25regulation of T-helper 2 cell differentiation (GO:0045628)4.78713682
26regulation of female receptivity (GO:0045924)4.75253267
27regulation of apoptotic cell clearance (GO:2000425)4.62520211
28response to gonadotropin (GO:0034698)4.52779961
29complement activation, alternative pathway (GO:0006957)4.50630131
30positive regulation of hormone metabolic process (GO:0032352)4.49841901
31ketone biosynthetic process (GO:0042181)4.43859155
32protein K11-linked deubiquitination (GO:0035871)4.41455427
33negative regulation of type 2 immune response (GO:0002829)4.39675286
34positive regulation of steroid biosynthetic process (GO:0010893)4.35576478
35regulation of T-helper 1 cell differentiation (GO:0045625)4.34789503
36hormone biosynthetic process (GO:0042446)4.26279528
37female mating behavior (GO:0060180)4.14769364
38detection of molecule of bacterial origin (GO:0032490)4.12154337
39cAMP biosynthetic process (GO:0006171)4.06687012
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.01206925
41seminiferous tubule development (GO:0072520)3.93381478
42aggressive behavior (GO:0002118)3.90464641
43regulation of transmission of nerve impulse (GO:0051969)3.88367461
44adhesion of symbiont to host (GO:0044406)3.85726687
45androgen metabolic process (GO:0008209)3.83251418
46negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.79990599
47potassium ion export (GO:0071435)3.78546567
48negative regulation of appetite (GO:0032099)3.78400089
49negative regulation of response to food (GO:0032096)3.78400089
50cellular response to growth hormone stimulus (GO:0071378)3.78315493
51response to water (GO:0009415)3.77515699
52cellular response to interferon-alpha (GO:0035457)3.75930357
53cellular response to zinc ion (GO:0071294)3.73841035
54progesterone metabolic process (GO:0042448)3.71905111
55detection of chemical stimulus involved in sensory perception (GO:0050907)3.63462940
56negative regulation of alpha-beta T cell differentiation (GO:0046639)3.61967513
57positive regulation of steroid metabolic process (GO:0045940)3.57894245
58low-density lipoprotein particle clearance (GO:0034383)3.54480796
59positive regulation of RNA splicing (GO:0033120)3.53290073
60cellular response to epinephrine stimulus (GO:0071872)3.49168102
61regulation of steroid hormone biosynthetic process (GO:0090030)3.46008052
62enteric nervous system development (GO:0048484)3.43308038
63renal system process involved in regulation of blood volume (GO:0001977)3.41518602
64adrenal gland development (GO:0030325)3.40375554
65desmosome organization (GO:0002934)3.38448921
66response to follicle-stimulating hormone (GO:0032354)3.36658504
67membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.35566124
68synaptic transmission, dopaminergic (GO:0001963)3.34605773
69hyaluronan catabolic process (GO:0030214)3.34178582
70drug transmembrane transport (GO:0006855)3.32830019
71negative regulation of necrotic cell death (GO:0060547)3.32537777
72positive regulation of amino acid transport (GO:0051957)3.31057505
73response to leptin (GO:0044321)3.30773971
74positive regulation of male gonad development (GO:2000020)3.30630007
75response to lead ion (GO:0010288)3.29516758
76regulation of protein sumoylation (GO:0033233)3.17631607
77regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.16331829
78cellular response to monoamine stimulus (GO:0071868)3.08173227
79cellular response to catecholamine stimulus (GO:0071870)3.08173227
80ovulation (GO:0030728)3.07111005
81linoleic acid metabolic process (GO:0043651)3.06491163
82membrane repolarization during action potential (GO:0086011)3.03505092
83response to corticosterone (GO:0051412)3.03495137
84heterotypic cell-cell adhesion (GO:0034113)3.01052431
85renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.00560747
86toxin metabolic process (GO:0009404)2.97703830
87detection of chemical stimulus (GO:0009593)2.95423385
88response to dietary excess (GO:0002021)2.93311289
89positive regulation of fatty acid biosynthetic process (GO:0045723)2.92986633
90regulation of feeding behavior (GO:0060259)2.91618332
91positive regulation of systemic arterial blood pressure (GO:0003084)2.90812884
92complement activation, classical pathway (GO:0006958)2.89744222
93positive regulation of heart contraction (GO:0045823)2.89477771
94sterol metabolic process (GO:0016125)2.86842775
95cellular response to antibiotic (GO:0071236)2.86667562
96endothelial cell differentiation (GO:0045446)2.83251996
97positive regulation of digestive system process (GO:0060456)2.82038949
98estrogen metabolic process (GO:0008210)2.81954990
99biotin metabolic process (GO:0006768)2.81153964
100high-density lipoprotein particle remodeling (GO:0034375)2.77749748
101atrial cardiac muscle cell action potential (GO:0086014)2.77246333
102benzene-containing compound metabolic process (GO:0042537)2.76840491
103positive regulation of renal sodium excretion (GO:0035815)2.76460584
104neuronal ion channel clustering (GO:0045161)2.75465572
105righting reflex (GO:0060013)2.74259133
106myotube differentiation (GO:0014902)2.73794369
107response to mineralocorticoid (GO:0051385)2.73444876
108L-phenylalanine catabolic process (GO:0006559)2.73368574
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73368574
110bile acid biosynthetic process (GO:0006699)2.72541901
111activation of protein kinase A activity (GO:0034199)2.71645544
112alpha-linolenic acid metabolic process (GO:0036109)2.71300470
113neurotransmitter catabolic process (GO:0042135)2.70611329
114response to gravity (GO:0009629)2.70077949
115regulation of axon extension involved in axon guidance (GO:0048841)2.68404750
116negative regulation of response to nutrient levels (GO:0032108)2.67234994
117negative regulation of response to extracellular stimulus (GO:0032105)2.67234994
118glucuronate metabolic process (GO:0019585)2.66741842
119uronic acid metabolic process (GO:0006063)2.66741842
120phosphate ion transmembrane transport (GO:0035435)2.65879955
121negative regulation of lipase activity (GO:0060192)2.65777504
122opsonization (GO:0008228)2.64762770
123positive regulation of triglyceride biosynthetic process (GO:0010867)2.64291807
124NADP metabolic process (GO:0006739)2.64114944
125regulation of triglyceride biosynthetic process (GO:0010866)2.60022747
126response to epinephrine (GO:0071871)2.55925663
127regulation of glutamate secretion (GO:0014048)2.54729128
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54645328
129L-phenylalanine metabolic process (GO:0006558)2.54645328
130positive regulation of protein kinase C signaling (GO:0090037)2.53184495
131response to insecticide (GO:0017085)2.50903114
132plasma lipoprotein particle clearance (GO:0034381)2.50893794
133negative regulation of complement activation (GO:0045916)2.50446997
134glycine transport (GO:0015816)2.48212938
135reverse cholesterol transport (GO:0043691)2.46287251
136positive regulation of triglyceride metabolic process (GO:0090208)2.45962375
137negative regulation of protein activation cascade (GO:2000258)2.45419080
138mating behavior (GO:0007617)2.45295377
139fusion of sperm to egg plasma membrane (GO:0007342)2.44015029
140cellular response to dexamethasone stimulus (GO:0071549)2.40911672
141adaptation of signaling pathway (GO:0023058)2.40716760
142response to dexamethasone (GO:0071548)2.39900346
143regulation of vasodilation (GO:0042312)2.38384447
144sterol catabolic process (GO:0016127)2.38193642
145cholesterol catabolic process (GO:0006707)2.38193642
146positive regulation of calcium ion import (GO:0090280)2.37032038
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.32008790
148steroid biosynthetic process (GO:0006694)2.31514943
149cellular ketone metabolic process (GO:0042180)2.31299197
150response to growth hormone (GO:0060416)2.30770986
151cholesterol efflux (GO:0033344)2.29982976
152triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.29391649
153peptidyl-glutamic acid carboxylation (GO:0017187)2.28200786
154protein carboxylation (GO:0018214)2.28200786
155cellular hormone metabolic process (GO:0034754)2.27686325
156head development (GO:0060322)2.27274709
157regulation of protein activation cascade (GO:2000257)2.25873451
158regulation of axon guidance (GO:1902667)2.24796747
159intracellular lipid transport (GO:0032365)2.24755466
160regulation of complement activation (GO:0030449)2.24140058
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.22595851
162sarcoplasmic reticulum calcium ion transport (GO:0070296)2.22553219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.07101169
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.66321382
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25294368
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46079490
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08857407
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.01474617
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99276537
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.91821208
9IGF1R_20145208_ChIP-Seq_DFB_Human2.79813377
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.59570118
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.57938647
12GATA1_19941826_ChIP-Seq_K562_Human2.54582911
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.37897659
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37660098
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34190633
16EZH2_22144423_ChIP-Seq_EOC_Human2.31209887
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30403168
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30403168
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30313987
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25361805
21VDR_22108803_ChIP-Seq_LS180_Human2.24218311
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.23833895
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21241975
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16279845
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08933856
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95570704
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94847861
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92374008
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89107337
30CLOCK_20551151_ChIP-Seq_293T_Human1.83056045
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82773808
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.81126821
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.80982205
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80194858
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.72826631
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67723233
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64793988
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62493174
39DROSHA_22980978_ChIP-Seq_HELA_Human1.54602740
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52965589
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52775801
42AR_21572438_ChIP-Seq_LNCaP_Human1.51400810
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49914058
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.46267121
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39963549
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39963549
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.39760787
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39232472
49GATA2_19941826_ChIP-Seq_K562_Human1.38879495
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.37292465
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35941558
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35162219
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32209421
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32059699
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.28062908
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26403500
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.26344258
58CTCF_27219007_Chip-Seq_Bcells_Human1.23508712
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17243323
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16671869
61LXR_22292898_ChIP-Seq_THP-1_Human1.15796452
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14864245
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14643426
64GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11823923
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11149958
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11013094
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10758555
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10552007
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.10452933
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09283597
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.09136555
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07689524
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07110472
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07048852
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06543467
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05694606
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.05080795
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.04208228
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02472712
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99462666
81BCAT_22108803_ChIP-Seq_LS180_Human0.99002842
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98389850
83LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97647400
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97548613
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.97346332
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.96628841
87P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96194930
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.96078649
89TP53_18474530_ChIP-ChIP_U2OS_Human0.95963871
90SCL_19346495_ChIP-Seq_HPC-7_Human0.95478821
91KDM2B_26808549_Chip-Seq_K562_Human0.94996071
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94582534
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93456890
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.92129557
95TBX20_22080862_ChIP-Seq_HEART_Mouse0.92129557
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90793236
97TBL1_22424771_ChIP-Seq_293T_Human0.90585175
98GBX2_23144817_ChIP-Seq_PC3_Human0.90359833
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89241413
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.88476674
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88448752
102FOXA2_19822575_ChIP-Seq_HepG2_Human0.87980484
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87179131
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87098688
105GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86618566
106CJUN_26792858_Chip-Seq_BT549_Human0.86204863
107AR_25329375_ChIP-Seq_VCAP_Human0.85450569
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85022406
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85022406
110CBX2_27304074_Chip-Seq_ESCs_Mouse0.84028861
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83619708
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82618662
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.82449490
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.81960110
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81485019
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.80923734
117SMAD4_21799915_ChIP-Seq_A2780_Human0.80726096
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79849355
119HNFA_21074721_ChIP-Seq_CACO-2_Human0.79549723
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78479386
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.78301339
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77826787
123AHR_22903824_ChIP-Seq_MCF-7_Human0.77259384
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76943852
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76202228
126EGR1_19032775_ChIP-ChIP_M12_Human0.76111203
127RACK7_27058665_Chip-Seq_MCF-7_Human0.75925755
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.75280222
129TP53_16413492_ChIP-PET_HCT116_Human0.74539594
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74334312
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74215290
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73633285
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73160551
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71467856
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.70692040
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.69660337
137ZNF274_21170338_ChIP-Seq_K562_Hela0.68718906
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.68651499
139TDRD3_21172665_ChIP-Seq_MCF-7_Human0.68069928
140KLF5_25053715_ChIP-Seq_YYC3_Human0.67593765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.71613557
2MP0008961_abnormal_basal_metabolism4.47196733
3MP0008995_early_reproductive_senescence4.23614795
4MP0008438_abnormal_cutaneous_collagen3.59594466
5MP0003705_abnormal_hypodermis_morpholog3.45416802
6MP0001958_emphysema3.10255590
7MP0000639_abnormal_adrenal_gland2.96316180
8MP0005275_abnormal_skin_tensile2.83153491
9MP0008875_abnormal_xenobiotic_pharmacok2.73979109
10MP0009384_cardiac_valve_regurgitation2.60902274
11MP0000751_myopathy2.53907135
12MP0003878_abnormal_ear_physiology2.46830887
13MP0005377_hearing/vestibular/ear_phenot2.46830887
14MP0004233_abnormal_muscle_weight2.43776014
15MP0005379_endocrine/exocrine_gland_phen2.37698175
16MP0005360_urolithiasis2.30849452
17MP0005409_darkened_coat_color2.26754460
18MP0002909_abnormal_adrenal_gland2.26547030
19MP0002139_abnormal_hepatobiliary_system2.23757819
20MP0002254_reproductive_system_inflammat2.14474226
21MP0004145_abnormal_muscle_electrophysio2.13688949
22MP0005503_abnormal_tendon_morphology2.11947988
23MP0004264_abnormal_extraembryonic_tissu2.10833373
24MP0003279_aneurysm2.09811066
25MP0005451_abnormal_body_composition1.95457471
26MP0001661_extended_life_span1.91163556
27MP0003191_abnormal_cellular_cholesterol1.88401381
28MP0004036_abnormal_muscle_relaxation1.86104914
29MP0001485_abnormal_pinna_reflex1.85716912
30MP0003724_increased_susceptibility_to1.85691519
31MP0005083_abnormal_biliary_tract1.83035003
32MP0004084_abnormal_cardiac_muscle1.80438161
33MP0001765_abnormal_ion_homeostasis1.78695099
34MP0005085_abnormal_gallbladder_physiolo1.77561270
35MP0003880_abnormal_central_pattern1.68285173
36MP0000230_abnormal_systemic_arterial1.63874325
37MP0000749_muscle_degeneration1.59775195
38MP0001984_abnormal_olfaction1.57156349
39MP0005365_abnormal_bile_salt1.56081795
40MP0005330_cardiomyopathy1.55092460
41MP0005448_abnormal_energy_balance1.54363367
42MP0010329_abnormal_lipoprotein_level1.52195702
43MP0004087_abnormal_muscle_fiber1.52135847
44MP0002837_dystrophic_cardiac_calcinosis1.48804310
45MP0003252_abnormal_bile_duct1.48659390
46MP0003879_abnormal_hair_cell1.45723557
47MP0006276_abnormal_autonomic_nervous1.44330343
48MP0003329_amyloid_beta_deposits1.43897143
49MP0003828_pulmonary_edema1.43686580
50MP0005319_abnormal_enzyme/_coenzyme1.42358003
51MP0008004_abnormal_stomach_pH1.42203350
52MP0004085_abnormal_heartbeat1.40717024
53MP0005595_abnormal_vascular_smooth1.40587944
54MP0008775_abnormal_heart_ventricle1.39145471
55MP0000750_abnormal_muscle_regeneration1.35672093
56MP0004883_abnormal_blood_vessel1.31089542
57MP0004130_abnormal_muscle_cell1.29242001
58MP0000747_muscle_weakness1.28352529
59MP0005584_abnormal_enzyme/coenzyme_acti1.28124387
60MP0003953_abnormal_hormone_level1.25811826
61MP0004185_abnormal_adipocyte_glucose1.23994000
62MP0001177_atelectasis1.22032548
63MP0000759_abnormal_skeletal_muscle1.16817336
64MP0009840_abnormal_foam_cell1.16580173
65MP0010368_abnormal_lymphatic_system1.14994037
66MP0002106_abnormal_muscle_physiology1.13650739
67MP0005171_absent_coat_pigmentation1.13350727
68MP0002998_abnormal_bone_remodeling1.13105735
69MP0002060_abnormal_skin_morphology1.10775432
70MP0004134_abnormal_chest_morphology1.10250978
71MP0001915_intracranial_hemorrhage1.09973473
72MP0004019_abnormal_vitamin_homeostasis1.09228929
73MP0004272_abnormal_basement_membrane1.06454636
74MP0005620_abnormal_muscle_contractility1.05298491
75MP0003137_abnormal_impulse_conducting1.03044955
76MP0000013_abnormal_adipose_tissue1.02821369
77MP0005636_abnormal_mineral_homeostasis1.02571511
78MP0000631_abnormal_neuroendocrine_gland1.02306081
79MP0002133_abnormal_respiratory_system1.02002844
80MP0005388_respiratory_system_phenotype1.02002844
81MP0005369_muscle_phenotype1.00261887
82MP0004381_abnormal_hair_follicle0.99450447
83MP0002118_abnormal_lipid_homeostasis0.99263887
84MP0003303_peritoneal_inflammation0.98567339
85MP0005332_abnormal_amino_acid0.98445528
86MP0005165_increased_susceptibility_to0.97850349
87MP0000920_abnormal_myelination0.95783761
88MP0006072_abnormal_retinal_apoptosis0.95228127
89MP0005666_abnormal_adipose_tissue0.95093564
90MP0003283_abnormal_digestive_organ0.93802805
91MP0003943_abnormal_hepatobiliary_system0.92780391
92MP0001756_abnormal_urination0.91659010
93MP0002332_abnormal_exercise_endurance0.91146650
94MP0002971_abnormal_brown_adipose0.90654348
95MP0002295_abnormal_pulmonary_circulatio0.89819962
96MP0001486_abnormal_startle_reflex0.89785888
97MP0002933_joint_inflammation0.87907094
98MP0004885_abnormal_endolymph0.87318101
99MP0002269_muscular_atrophy0.86613618
100MP0000343_altered_response_to0.86537479
101MP0005164_abnormal_response_to0.85509869
102MP0005647_abnormal_sex_gland0.84567807
103MP0003186_abnormal_redox_activity0.84451659
104MP0003786_premature_aging0.84072094
105MP0009643_abnormal_urine_homeostasis0.83586652
106MP0005464_abnormal_platelet_physiology0.83088923
107MP0010630_abnormal_cardiac_muscle0.82567496
108MP0009379_abnormal_foot_pigmentation0.82517900
109MP0005646_abnormal_pituitary_gland0.82434317
110MP0001501_abnormal_sleep_pattern0.82219559
111MP0004484_altered_response_of0.81888468
112MP0003635_abnormal_synaptic_transmissio0.80653146
113MP0001440_abnormal_grooming_behavior0.80188770
114MP0002272_abnormal_nervous_system0.79560607
115MP0004133_heterotaxia0.78557279
116MP0003638_abnormal_response/metabolism_0.78344101
117MP0000249_abnormal_blood_vessel0.77094338
118MP0005375_adipose_tissue_phenotype0.75744328
119MP0000609_abnormal_liver_physiology0.75649869
120MP0009764_decreased_sensitivity_to0.75401706
121MP0000604_amyloidosis0.75065533
122MP0000470_abnormal_stomach_morphology0.75064310
123MP0009745_abnormal_behavioral_response0.74746507
124MP0001544_abnormal_cardiovascular_syste0.74300741
125MP0005385_cardiovascular_system_phenoty0.74300741
126MP0002127_abnormal_cardiovascular_syste0.73818025
127MP0001270_distended_abdomen0.73399325
128MP0009780_abnormal_chondrocyte_physiolo0.73296183
129MP0004859_abnormal_synaptic_plasticity0.72941195
130MP0009642_abnormal_blood_homeostasis0.72693288
131MP0000465_gastrointestinal_hemorrhage0.72259961
132MP0002557_abnormal_social/conspecific_i0.71647932
133MP0001879_abnormal_lymphatic_vessel0.71142368
134MP0001533_abnormal_skeleton_physiology0.70863301
135MP0003122_maternal_imprinting0.70480270
136MP0002796_impaired_skin_barrier0.69297925
137MP0002108_abnormal_muscle_morphology0.69203745
138MP0005387_immune_system_phenotype0.68807085
139MP0001790_abnormal_immune_system0.68807085
140MP0008469_abnormal_protein_level0.64770867
141MP0002078_abnormal_glucose_homeostasis0.62802160
142MP0005334_abnormal_fat_pad0.61510001
143MP0003011_delayed_dark_adaptation0.60049391
144MP0005220_abnormal_exocrine_pancreas0.58615226
145MP0000598_abnormal_liver_morphology0.58307365
146MP0003941_abnormal_skin_development0.57309372
147MP0002928_abnormal_bile_duct0.56967675
148MP0001119_abnormal_female_reproductive0.54689815
149MP0002136_abnormal_kidney_physiology0.51849064
150MP0001299_abnormal_eye_distance/0.48688028
151MP0001905_abnormal_dopamine_level0.44664106
152MP0002128_abnormal_blood_circulation0.44522564
153MP0002135_abnormal_kidney_morphology0.42989991
154MP0003690_abnormal_glial_cell0.40747860
155MP0003632_abnormal_nervous_system0.40115860
156MP0008569_lethality_at_weaning0.39848767

Predicted human phenotypes

RankGene SetZ-score
1Overgrowth (HP:0001548)5.63805900
2Recurrent gram-negative bacterial infections (HP:0005420)4.90041800
3Renal salt wasting (HP:0000127)4.88189729
4Hypokalemic alkalosis (HP:0001949)4.64879923
5Abnormality of calcium-phosphate metabolism (HP:0100530)4.45793939
6Neonatal onset (HP:0003623)4.18407005
7Ventricular fibrillation (HP:0001663)4.17578530
8Amelogenesis imperfecta (HP:0000705)4.12747117
9Abnormality of dental color (HP:0011073)3.93676612
10Increased connective tissue (HP:0009025)3.90825558
11Male pseudohermaphroditism (HP:0000037)3.86163703
12Clitoromegaly (HP:0000057)3.76800497
13Increased circulating renin level (HP:0000848)3.76443487
14Distal lower limb muscle weakness (HP:0009053)3.75429606
15Progressive inability to walk (HP:0002505)3.72232923
16Hypokalemia (HP:0002900)3.55387747
17Systemic lupus erythematosus (HP:0002725)3.49962097
18Congenital sensorineural hearing impairment (HP:0008527)3.49135418
19Deep venous thrombosis (HP:0002625)3.46780506
20Premature rupture of membranes (HP:0001788)3.35636996
21Wrist flexion contracture (HP:0001239)3.23011029
22Hyporeflexia of lower limbs (HP:0002600)3.21014690
23Protrusio acetabuli (HP:0003179)3.20352204
24Polyuria (HP:0000103)3.19828164
25Neurofibrillary tangles (HP:0002185)3.15653645
26Prolonged QT interval (HP:0001657)3.12955025
27Peritonitis (HP:0002586)3.11844952
28Abnormality of renin-angiotensin system (HP:0000847)3.11426679
29Decreased circulating renin level (HP:0003351)3.09855387
30Abnormal urine output (HP:0012590)3.07393690
31Hyperaldosteronism (HP:0000859)3.05884139
32Thick nail (HP:0001805)3.05138468
33Glomerulonephritis (HP:0000099)3.01409578
34Exercise-induced myalgia (HP:0003738)2.99423415
35Hyperkalemia (HP:0002153)2.98693830
36Sparse lateral eyebrow (HP:0005338)2.98518665
37Muscle fiber splitting (HP:0003555)2.97667061
38Cerebral inclusion bodies (HP:0100314)2.97625159
39Osteomalacia (HP:0002749)2.94278591
40Hypoplastic pelvis (HP:0008839)2.88946697
41Type 1 muscle fiber predominance (HP:0003803)2.88454753
42Distal arthrogryposis (HP:0005684)2.88177515
43Abnormality of the dental pulp (HP:0006479)2.86247061
44Spinal rigidity (HP:0003306)2.84376389
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83371559
46Axonal loss (HP:0003447)2.80516638
47Thin bony cortex (HP:0002753)2.80248446
48Hyperglycinuria (HP:0003108)2.79986656
49Mesangial abnormality (HP:0001966)2.77599212
50Sudden death (HP:0001699)2.76131383
51Episodic fever (HP:0001954)2.75453126
52Accelerated skeletal maturation (HP:0005616)2.74935265
53Abnormality of the fingertips (HP:0001211)2.71339362
54Fragile skin (HP:0001030)2.69741538
55Orthostatic hypotension (HP:0001278)2.68016708
56Distal lower limb amyotrophy (HP:0008944)2.67960542
57Enlarged penis (HP:0000040)2.65991089
58Bifid scrotum (HP:0000048)2.63834750
59Muscle hypertrophy of the lower extremities (HP:0008968)2.61814441
60Gonadal dysgenesis (HP:0000133)2.58670039
61Hypophosphatemic rickets (HP:0004912)2.56636510
62Testicular neoplasm (HP:0010788)2.55399179
63Abnormality of renal excretion (HP:0011036)2.51936440
64Calf muscle hypertrophy (HP:0008981)2.51870122
65Aplasia of the musculature (HP:0100854)2.49217925
66Complement deficiency (HP:0004431)2.48573353
67Mitral stenosis (HP:0001718)2.43489358
68Xanthomatosis (HP:0000991)2.42551060
69Lymphangioma (HP:0100764)2.40990322
70Abnormality of renal resorption (HP:0011038)2.40701628
71Round ear (HP:0100830)2.39283735
72Abnormality of the clitoris (HP:0000056)2.38074265
73Aplasia involving bones of the upper limbs (HP:0009823)2.34760531
74Aplasia of the phalanges of the hand (HP:0009802)2.34760531
75Aplasia involving bones of the extremities (HP:0009825)2.34760531
76Azoospermia (HP:0000027)2.34015298
77Hypoplasia of the uterus (HP:0000013)2.33151381
78Alkalosis (HP:0001948)2.32102114
79EMG: myopathic abnormalities (HP:0003458)2.31642143
80Aplasia/hypoplasia of the uterus (HP:0008684)2.31001885
81Gynecomastia (HP:0000771)2.28037603
82Prolonged partial thromboplastin time (HP:0003645)2.27030399
83Abnormality of complement system (HP:0005339)2.23707819
84Difficulty running (HP:0009046)2.23672544
85Nephritis (HP:0000123)2.22471424
86Large earlobe (HP:0009748)2.21177312
87Lower limb amyotrophy (HP:0007210)2.17875524
88Cervical subluxation (HP:0003308)2.14230645
89Hypoalphalipoproteinemia (HP:0003233)2.13054168
90Precocious puberty (HP:0000826)2.11926132
91Metaphyseal dysplasia (HP:0100255)2.11650861
92Abnormality of carpal bone ossification (HP:0006257)2.11365455
93Abnormal delivery (HP:0001787)2.09308903
94Sex reversal (HP:0012245)2.08112181
95Abnormal sex determination (HP:0012244)2.08112181
96Abnormality of glycine metabolism (HP:0010895)2.06073900
97Abnormality of serine family amino acid metabolism (HP:0010894)2.06073900
98Increased variability in muscle fiber diameter (HP:0003557)2.05836015
99Peripheral hypomyelination (HP:0007182)2.05726748
100Bilateral sensorineural hearing impairment (HP:0008619)2.04898351
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03203550
102Exercise-induced muscle cramps (HP:0003710)2.02673051
103Vascular tortuosity (HP:0004948)2.02055848
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.01025633
105Abnormality of potassium homeostasis (HP:0011042)2.00957417
106Muscle fiber inclusion bodies (HP:0100299)2.00305194
107Syncope (HP:0001279)1.99997837
108Arterial tortuosity (HP:0005116)1.98244713
109Aortic aneurysm (HP:0004942)1.96002048
110Striae distensae (HP:0001065)1.95511581
111Nemaline bodies (HP:0003798)1.94634247
112Ankle contracture (HP:0006466)1.94084711
113Abnormality of the Achilles tendon (HP:0005109)1.92265952
114Broad metatarsal (HP:0001783)1.90985080
115Turricephaly (HP:0000262)1.90484453
116Abnormality of secondary sexual hair (HP:0009888)1.90035166
117Abnormality of the axillary hair (HP:0100134)1.90035166
118Right ventricular cardiomyopathy (HP:0011663)1.89722410
119Abnormality of skeletal muscle fiber size (HP:0012084)1.88537230
120Hyperglycinemia (HP:0002154)1.88421311
121Abnormality of the calf musculature (HP:0001430)1.88405067
122Muscle stiffness (HP:0003552)1.87782328
123Atrial fibrillation (HP:0005110)1.87732235
124Joint hemorrhage (HP:0005261)1.87034186
125Atrioventricular block (HP:0001678)1.85706396
126Breech presentation (HP:0001623)1.84488154
127Inability to walk (HP:0002540)1.83241902
128Ketoacidosis (HP:0001993)1.82883492
129Primary atrial arrhythmia (HP:0001692)1.82244650
130Breast hypoplasia (HP:0003187)1.81862002
131Achilles tendon contracture (HP:0001771)1.81715534
132Anal stenosis (HP:0002025)1.79914672
133Decreased testicular size (HP:0008734)1.79664663
134Ketosis (HP:0001946)1.79413054
135Shallow orbits (HP:0000586)1.79052521
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77180420
137Abnormal EKG (HP:0003115)1.76823117
138Abnormal umbilical cord blood vessels (HP:0011403)1.76799518
139Single umbilical artery (HP:0001195)1.76799518
140Abnormality of the fetal cardiovascular system (HP:0010948)1.76799518
141Adrenal overactivity (HP:0002717)1.76615600
142Esophageal varix (HP:0002040)1.76328081
143Persistence of primary teeth (HP:0006335)1.75932263
144Myoglobinuria (HP:0002913)1.75782210
145Ureteral duplication (HP:0000073)1.75002858
146Hypercalciuria (HP:0002150)1.74257285
147Bradycardia (HP:0001662)1.74130006
148Hip contracture (HP:0003273)1.73064132
149Difficulty climbing stairs (HP:0003551)1.72830906
150Absent hand (HP:0004050)1.72147716
151Abnormality of transition element cation homeostasis (HP:0011030)1.70588345
152Asymmetric septal hypertrophy (HP:0001670)1.68105172
153Myocardial infarction (HP:0001658)1.68007318
154Menorrhagia (HP:0000132)1.67052636
155Hypospadias (HP:0000047)1.64512719
156Abnormality of the aortic arch (HP:0012303)1.63289940
157Nephrocalcinosis (HP:0000121)1.63107585
158Abnormal spermatogenesis (HP:0008669)1.62625359
159Abnormal ossification of hand bones (HP:0005921)1.61161572
160Abnormal hand bone ossification (HP:0010660)1.59782846
161Keratoconjunctivitis sicca (HP:0001097)1.55419499
162Hypoparathyroidism (HP:0000829)1.53855810
163Depressed nasal tip (HP:0000437)1.53782158
164Autoimmune thrombocytopenia (HP:0001973)1.53518624
165Primary amenorrhea (HP:0000786)1.49230210
166Toxemia of pregnancy (HP:0100603)1.44149769
167Limited hip movement (HP:0008800)1.43661007
168Secondary amenorrhea (HP:0000869)1.43636887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.86866898
2DDR24.06821234
3EPHB13.67272761
4GRK72.73255355
5MAP4K12.66443951
6BCKDK2.62603906
7TNIK2.58142670
8TGFBR22.57878967
9TTN2.46018658
10TRIB32.45693279
11MOS2.39081343
12STK32.32594382
13PIK3CG2.31367724
14GRK52.14840091
15SIK12.13930249
16PHKG12.03670732
17PHKG22.03670732
18MELK1.90921561
19PTK61.84589605
20CDC42BPA1.84532071
21RIPK41.81421136
22JAK11.80229528
23MAP3K51.72569912
24CASK1.67457367
25FER1.59021397
26PIK3CA1.57319027
27TAOK31.49863969
28MUSK1.49260731
29STK101.49011697
30ICK1.45581543
31PINK11.43311992
32PKN11.41371289
33STK391.38536140
34PLK21.27575691
35MAPK121.24760943
36PTK2B1.23032836
37NTRK31.22702119
38AKT31.22696224
39FGFR41.19009004
40CAMK1G1.16038055
41EPHA41.13733650
42CSNK1A1L1.13419278
43LATS21.11847333
44ROCK21.09814182
45DMPK1.06009228
46CAMK2B1.05096504
47TRPM71.03277314
48RIPK11.02118163
49FES1.00651180
50MAP3K21.00009418
51MAPK150.99709016
52PIM10.99387178
53PDGFRA0.95588867
54HIPK20.94903793
55GSK3A0.90282958
56CSNK1G10.89705151
57AKT20.89507121
58MAP3K10.87266555
59PDPK10.87162811
60PAK20.86583356
61CSNK1G30.86343485
62JAK20.83898245
63BMPR20.82501736
64PRKD10.82260537
65MARK20.82058174
66CDK70.81989308
67OBSCN0.79151155
68PDK10.77341444
69KDR0.76897086
70FGFR30.74340251
71CAMK2A0.74165398
72OXSR10.73549888
73MARK10.73040174
74CAMK2D0.72577161
75EPHA30.72208970
76SGK10.71207392
77CSNK1G20.70104744
78LIMK10.70060146
79BLK0.69909054
80EPHB20.69681795
81SIK20.66504578
82PRPF4B0.66302115
83TAOK10.64448885
84NEK90.64248222
85CLK10.63800692
86MST1R0.62065138
87ROCK10.61641201
88CAMK1D0.59196904
89DAPK30.57717573
90YES10.56199305
91CDK50.56168412
92EIF2AK20.56057823
93TIE10.55193309
94INSRR0.54647410
95MAP3K70.53727792
96ERBB40.52553882
97CAMK2G0.52420270
98LATS10.52013298
99MAPKAPK50.50652891
100PRKAA10.50161144
101NTRK10.49531223
102DYRK1B0.48146687
103PNCK0.47758016
104SYK0.47320267
105LRRK20.47126613
106GRK10.46863784
107SRC0.46137456
108NTRK20.46037917
109MAPK70.45070723
110MYLK0.44919023
111CDK190.44581769
112MAP3K110.44300423
113DYRK20.44086705
114PRKAA20.43817764
115MAPK30.43757389
116PRKACA0.43079102
117FGFR10.43052173
118MAPK40.42833274
119GRK60.42728396
120PAK30.42649748
121TAOK20.42498009
122PTK20.41930713
123PKN20.41657614
124CSF1R0.40827216
125DAPK20.40375187
126MAP4K20.40114446
127CSK0.40044537
128ADRBK10.39860912
129PRKACB0.38748506
130PRKACG0.38568005
131PRKG10.37823136
132MINK10.37805080
133CDK11A0.37530871
134PRKCH0.37353020
135PRKCE0.36727264
136PRKCZ0.36269854
137RET0.34640644
138MAP2K60.34303064
139NLK0.32843126
140MAP3K60.32751270
141ADRBK20.32415600
142MTOR0.32077383
143RPS6KA30.31435764
144PDGFRB0.25430138
145EEF2K0.25002718
146ITK0.21937815
147LMTK20.21552229
148ERBB20.20611936
149BTK0.20305193
150TBK10.19963123
151KIT0.19662232
152CAMK40.19559469
153CAMK10.18421152
154PRKG20.17497562
155PRKCQ0.16946553

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.91790233
2Steroid hormone biosynthesis_Homo sapiens_hsa001403.99762306
3Aldosterone synthesis and secretion_Homo sapiens_hsa049252.86664498
4Caffeine metabolism_Homo sapiens_hsa002322.61410211
5Olfactory transduction_Homo sapiens_hsa047402.51853580
6Nitrogen metabolism_Homo sapiens_hsa009102.22176028
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13708276
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12244641
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09953988
10Fatty acid metabolism_Homo sapiens_hsa012122.00098772
11Fatty acid degradation_Homo sapiens_hsa000711.98467185
12PPAR signaling pathway_Homo sapiens_hsa033201.97583711
13Propanoate metabolism_Homo sapiens_hsa006401.94995960
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93033506
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92897604
16Complement and coagulation cascades_Homo sapiens_hsa046101.89719649
17Ovarian steroidogenesis_Homo sapiens_hsa049131.89060023
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.76734493
19Steroid biosynthesis_Homo sapiens_hsa001001.71685715
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61746393
21Vibrio cholerae infection_Homo sapiens_hsa051101.56434588
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51184599
23Staphylococcus aureus infection_Homo sapiens_hsa051501.50380546
24Gastric acid secretion_Homo sapiens_hsa049711.46051326
25Butanoate metabolism_Homo sapiens_hsa006501.43646309
26Tryptophan metabolism_Homo sapiens_hsa003801.40030740
27Tyrosine metabolism_Homo sapiens_hsa003501.38320555
28Fatty acid biosynthesis_Homo sapiens_hsa000611.36074049
29Pancreatic secretion_Homo sapiens_hsa049721.34497399
30Arginine biosynthesis_Homo sapiens_hsa002201.33619999
31Folate biosynthesis_Homo sapiens_hsa007901.32893567
32Fatty acid elongation_Homo sapiens_hsa000621.30081628
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.27389329
34Bile secretion_Homo sapiens_hsa049761.26581987
35Cardiac muscle contraction_Homo sapiens_hsa042601.21736563
36Gap junction_Homo sapiens_hsa045401.20551287
37Hedgehog signaling pathway_Homo sapiens_hsa043401.20031143
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16923027
39Chemical carcinogenesis_Homo sapiens_hsa052041.16746029
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15512542
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08446220
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06635955
43Dilated cardiomyopathy_Homo sapiens_hsa054141.06075257
44Thyroid hormone synthesis_Homo sapiens_hsa049181.05652927
45Renin secretion_Homo sapiens_hsa049241.04606907
46Fat digestion and absorption_Homo sapiens_hsa049751.04349527
47Peroxisome_Homo sapiens_hsa041461.01096484
48Basal cell carcinoma_Homo sapiens_hsa052171.00019785
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99054888
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97463053
51Collecting duct acid secretion_Homo sapiens_hsa049660.96150392
52Platelet activation_Homo sapiens_hsa046110.94856878
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92900581
54Vitamin digestion and absorption_Homo sapiens_hsa049770.92322106
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.91839496
56beta-Alanine metabolism_Homo sapiens_hsa004100.87248516
57ECM-receptor interaction_Homo sapiens_hsa045120.87031063
58Pyruvate metabolism_Homo sapiens_hsa006200.86313586
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85860014
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.84311156
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.84264637
62Histidine metabolism_Homo sapiens_hsa003400.82262683
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81081916
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80958216
65Carbon metabolism_Homo sapiens_hsa012000.80598721
66Starch and sucrose metabolism_Homo sapiens_hsa005000.79829308
67Prion diseases_Homo sapiens_hsa050200.79539770
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78885400
69Arachidonic acid metabolism_Homo sapiens_hsa005900.76761414
70Ether lipid metabolism_Homo sapiens_hsa005650.76327454
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73477997
72Insulin secretion_Homo sapiens_hsa049110.72628793
73ABC transporters_Homo sapiens_hsa020100.69693015
74GABAergic synapse_Homo sapiens_hsa047270.69644477
75Alzheimers disease_Homo sapiens_hsa050100.69365985
76Synaptic vesicle cycle_Homo sapiens_hsa047210.69318864
77Circadian rhythm_Homo sapiens_hsa047100.67182510
78Cocaine addiction_Homo sapiens_hsa050300.67027694
79Melanogenesis_Homo sapiens_hsa049160.66856107
80Nicotine addiction_Homo sapiens_hsa050330.66686619
81Estrogen signaling pathway_Homo sapiens_hsa049150.66351522
82Axon guidance_Homo sapiens_hsa043600.66217883
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65951027
84Cholinergic synapse_Homo sapiens_hsa047250.65310370
85Phenylalanine metabolism_Homo sapiens_hsa003600.65183987
86Insulin resistance_Homo sapiens_hsa049310.63712756
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62779322
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59677436
89Oxytocin signaling pathway_Homo sapiens_hsa049210.59071953
90Taste transduction_Homo sapiens_hsa047420.58425813
91Glucagon signaling pathway_Homo sapiens_hsa049220.58411035
92Systemic lupus erythematosus_Homo sapiens_hsa053220.55357465
93Retinol metabolism_Homo sapiens_hsa008300.55093825
94Calcium signaling pathway_Homo sapiens_hsa040200.53906508
95Glycerolipid metabolism_Homo sapiens_hsa005610.53493049
96Protein digestion and absorption_Homo sapiens_hsa049740.53222354
97Salivary secretion_Homo sapiens_hsa049700.52181588
98Sulfur metabolism_Homo sapiens_hsa009200.50825385
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50721255
100cAMP signaling pathway_Homo sapiens_hsa040240.50439840
101Linoleic acid metabolism_Homo sapiens_hsa005910.49591601
102Other glycan degradation_Homo sapiens_hsa005110.49402119
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48107361
104Oxidative phosphorylation_Homo sapiens_hsa001900.47098296
105Pertussis_Homo sapiens_hsa051330.46913308
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46502208
107Prolactin signaling pathway_Homo sapiens_hsa049170.45761983
108Glutamatergic synapse_Homo sapiens_hsa047240.45407052
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.45388724
110Sulfur relay system_Homo sapiens_hsa041220.44456827
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43982953
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42184494
113Focal adhesion_Homo sapiens_hsa045100.42138202
114Proteoglycans in cancer_Homo sapiens_hsa052050.41209224
115Amphetamine addiction_Homo sapiens_hsa050310.40897521
116Arginine and proline metabolism_Homo sapiens_hsa003300.40757796
117Circadian entrainment_Homo sapiens_hsa047130.40423945
118Wnt signaling pathway_Homo sapiens_hsa043100.37916104
119Amoebiasis_Homo sapiens_hsa051460.37054459
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36878526
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36615680
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.35102024
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34102536
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34071371
125Morphine addiction_Homo sapiens_hsa050320.33725447
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.33318137
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32869674
128Dorso-ventral axis formation_Homo sapiens_hsa043200.32654125
129GnRH signaling pathway_Homo sapiens_hsa049120.32291592
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31786841
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30405319
132Serotonergic synapse_Homo sapiens_hsa047260.29110026
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23861323
134Chemokine signaling pathway_Homo sapiens_hsa040620.18261174
135Pentose phosphate pathway_Homo sapiens_hsa000300.17594292
136Rap1 signaling pathway_Homo sapiens_hsa040150.17239856
137Insulin signaling pathway_Homo sapiens_hsa049100.08564585

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