TNXB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.46598663
2carnitine shuttle (GO:0006853)4.88884113
3fatty acid transmembrane transport (GO:1902001)4.72727578
4cardiac myofibril assembly (GO:0055003)4.52959767
5sarcomere organization (GO:0045214)4.47412088
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.46990583
7regulation of sequestering of triglyceride (GO:0010889)4.43263380
8plasma membrane repair (GO:0001778)4.39169722
9actin-myosin filament sliding (GO:0033275)4.28700616
10muscle filament sliding (GO:0030049)4.28700616
11positive regulation of fatty acid beta-oxidation (GO:0032000)4.25174579
12positive regulation of fatty acid oxidation (GO:0046321)4.08987317
13myofibril assembly (GO:0030239)4.08560124
14low-density lipoprotein particle clearance (GO:0034383)4.04156609
15regulation of skeletal muscle contraction (GO:0014819)4.02472001
16carnitine transmembrane transport (GO:1902603)3.74409954
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.72193822
18regulation of fatty acid oxidation (GO:0046320)3.71584039
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67655410
20actin-mediated cell contraction (GO:0070252)3.67329298
21hemidesmosome assembly (GO:0031581)3.65483161
22peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.62656580
23cell migration involved in heart development (GO:0060973)3.60149279
24cellular response to epinephrine stimulus (GO:0071872)3.57184741
25* collagen fibril organization (GO:0030199)3.53258536
26negative regulation of cardiac muscle tissue growth (GO:0055022)3.51813715
27negative regulation of heart growth (GO:0061117)3.51813715
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46891289
29collagen catabolic process (GO:0030574)3.46238879
30lipid particle organization (GO:0034389)3.45181395
31carnitine transport (GO:0015879)3.42598152
32amino-acid betaine transport (GO:0015838)3.42598152
33barbed-end actin filament capping (GO:0051016)3.39823301
34biotin metabolic process (GO:0006768)3.37071299
35negative regulation of potassium ion transmembrane transport (GO:1901380)3.35962237
36regulation of fatty acid beta-oxidation (GO:0031998)3.34736420
37* collagen metabolic process (GO:0032963)3.32812510
38regulation of p38MAPK cascade (GO:1900744)3.30746684
39* multicellular organismal macromolecule metabolic process (GO:0044259)3.28656836
40tricarboxylic acid cycle (GO:0006099)3.27465598
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.26637909
42multicellular organismal catabolic process (GO:0044243)3.26549031
43* extracellular matrix assembly (GO:0085029)3.24428799
44skeletal muscle adaptation (GO:0043501)3.23281340
45heart trabecula formation (GO:0060347)3.17855387
46* multicellular organismal metabolic process (GO:0044236)3.15831223
47brown fat cell differentiation (GO:0050873)3.15400335
48fatty acid beta-oxidation (GO:0006635)3.14903422
49cardiac muscle cell development (GO:0055013)3.13011163
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.12809787
51ventricular cardiac muscle cell action potential (GO:0086005)3.11733144
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10107802
53cardiac muscle contraction (GO:0060048)3.10042359
54actomyosin structure organization (GO:0031032)3.06724485
55striated muscle hypertrophy (GO:0014897)3.05880613
56valine metabolic process (GO:0006573)3.04533539
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03469176
58desmosome organization (GO:0002934)3.03226654
59vascular endothelial growth factor signaling pathway (GO:0038084)3.03220586
60positive regulation of glycogen biosynthetic process (GO:0045725)3.02735165
61actin filament-based movement (GO:0030048)3.02176537
62cardiac cell development (GO:0055006)3.00930249
63triglyceride catabolic process (GO:0019433)3.00533148
64response to epinephrine (GO:0071871)2.99499836
65myelination in peripheral nervous system (GO:0022011)2.97589928
66peripheral nervous system axon ensheathment (GO:0032292)2.97589928
67endocrine hormone secretion (GO:0060986)2.96227142
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.93978353
69extracellular matrix disassembly (GO:0022617)2.90733155
70trabecula formation (GO:0060343)2.89142243
71creatine metabolic process (GO:0006600)2.88987262
72cell-substrate junction assembly (GO:0007044)2.88351684
732-oxoglutarate metabolic process (GO:0006103)2.87629509
74glomerular filtration (GO:0003094)2.87241695
75regulation of relaxation of muscle (GO:1901077)2.85599045
76basement membrane organization (GO:0071711)2.85521309
77intracellular lipid transport (GO:0032365)2.83524308
78fibroblast migration (GO:0010761)2.82832038
79apoptotic cell clearance (GO:0043277)2.82743669
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82416393
81negative regulation of smooth muscle cell migration (GO:0014912)2.82409265
82white fat cell differentiation (GO:0050872)2.82389258
83keratan sulfate catabolic process (GO:0042340)2.80560672
84glomerular basement membrane development (GO:0032836)2.80397173
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.79799938
86epithelial cell-cell adhesion (GO:0090136)2.79723830
87surfactant homeostasis (GO:0043129)2.79409297
88sequestering of extracellular ligand from receptor (GO:0035581)2.77595138
89growth hormone secretion (GO:0030252)2.76866462
90ovulation from ovarian follicle (GO:0001542)2.76720579
91atrioventricular valve morphogenesis (GO:0003181)2.73600108
92positive regulation of p38MAPK cascade (GO:1900745)2.73440164
93renal filtration (GO:0097205)2.72295776
94regulation of cholesterol storage (GO:0010885)2.72251521
95positive regulation of receptor recycling (GO:0001921)2.72066730
96cGMP-mediated signaling (GO:0019934)2.71776154
97muscle hypertrophy (GO:0014896)2.71671170
98neutral lipid catabolic process (GO:0046461)2.71190616
99acylglycerol catabolic process (GO:0046464)2.71190616
100bone trabecula formation (GO:0060346)2.69705316
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.68778297
102regulation of actin filament-based movement (GO:1903115)2.68538398
103negative regulation of cardiac muscle hypertrophy (GO:0010614)2.68061571
104blood vessel maturation (GO:0001955)2.67592529
105negative regulation of Rho protein signal transduction (GO:0035024)2.67390147
106cardiac muscle tissue morphogenesis (GO:0055008)2.66925427
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.66577397
108metanephric mesenchyme development (GO:0072075)2.66531407
109fatty acid oxidation (GO:0019395)2.65306908
110metanephric nephron epithelium development (GO:0072243)2.65133887
111regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65054573
112cell proliferation involved in metanephros development (GO:0072203)2.64951724
113cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64331820
114NADH metabolic process (GO:0006734)2.64235011
115* extracellular fibril organization (GO:0043206)2.64141718
116positive regulation of glycogen metabolic process (GO:0070875)2.63828930
117negative regulation of fatty acid transport (GO:2000192)2.62518310
118skin morphogenesis (GO:0043589)2.62315481
119negative regulation of muscle hypertrophy (GO:0014741)2.62046732
120regulation of integrin-mediated signaling pathway (GO:2001044)2.61284202
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.59918586
122fatty acid catabolic process (GO:0009062)2.59543046
123negative regulation of stress fiber assembly (GO:0051497)2.59346135
124positive regulation of endothelial cell apoptotic process (GO:2000353)2.57882795
125endothelium development (GO:0003158)2.54231424
126endothelial cell morphogenesis (GO:0001886)2.53037297
127negative regulation of protein localization to cell surface (GO:2000009)2.52373629
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51974516
129cell volume homeostasis (GO:0006884)2.51853733
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50903493
131cardiac muscle hypertrophy (GO:0003300)2.50362356
132neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.49705390
133metanephric tubule development (GO:0072170)2.49505232
134metanephric nephron tubule development (GO:0072234)2.49505232
135adherens junction assembly (GO:0034333)2.43848106
136metanephric epithelium development (GO:0072207)2.43498306
137positive regulation of cholesterol efflux (GO:0010875)2.42409240
138response to water (GO:0009415)2.42231238
139positive regulation of protein kinase C signaling (GO:0090037)2.40876257
140stress fiber assembly (GO:0043149)2.39718392
141negative regulation of erythrocyte differentiation (GO:0045647)2.39580643
142lymphangiogenesis (GO:0001946)2.38566232
143* fibril organization (GO:0097435)2.38385962
144negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.37138210
145focal adhesion assembly (GO:0048041)2.34406234
146cell-substrate adherens junction assembly (GO:0007045)2.34406234
147phagocytosis, recognition (GO:0006910)2.34139382
148cellular response to monoamine stimulus (GO:0071868)2.34033521
149cellular response to catecholamine stimulus (GO:0071870)2.34033521
150angiogenesis involved in wound healing (GO:0060055)2.33388487
151regulation of transforming growth factor beta1 production (GO:0032908)2.32126088
152endothelial cell chemotaxis (GO:0035767)2.30347723
153adhesion of symbiont to host cell (GO:0044650)2.29893784
154virion attachment to host cell (GO:0019062)2.29893784
155protein localization to cell surface (GO:0034394)2.29317247
156cellular response to growth hormone stimulus (GO:0071378)2.29255138
157smooth muscle tissue development (GO:0048745)2.29119244
158kidney mesenchyme development (GO:0072074)2.28982203
159polyol transport (GO:0015791)2.28334866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.53300471
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.31974037
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.75542525
4CLOCK_20551151_ChIP-Seq_293T_Human3.25031199
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.02877689
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87916449
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.45399542
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34887346
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30599377
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.30267968
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19023301
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.14095012
13TBX20_22080862_ChIP-Seq_HEART_Mouse2.14095012
14ZNF263_19887448_ChIP-Seq_K562_Human2.11214280
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.04799854
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99213917
17LXR_22158963_ChIP-Seq_LIVER_Mouse1.93264508
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92721174
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.88019151
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.81182676
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80435300
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74592412
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71454828
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.70722145
25CJUN_26792858_Chip-Seq_BT549_Human1.64279719
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61894251
27* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61813925
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61765886
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55319032
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53498550
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.50395989
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46524881
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45502499
34* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41461818
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41374280
36EZH2_22144423_ChIP-Seq_EOC_Human1.41132871
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40186303
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.39146716
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38780801
40* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38203143
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35351144
42GATA1_22025678_ChIP-Seq_K562_Human1.34460308
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.33865050
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32842938
45PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30090916
46* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26352936
47* EED_16625203_ChIP-ChIP_MESCs_Mouse1.25398791
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25276598
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22524060
50LXR_22292898_ChIP-Seq_THP-1_Human1.21010470
51* DROSHA_22980978_ChIP-Seq_HELA_Human1.20301767
52* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20013164
53* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20013164
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19332703
55* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18923648
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18918505
57KDM2B_26808549_Chip-Seq_K562_Human1.18318174
58RACK7_27058665_Chip-Seq_MCF-7_Human1.15980209
59* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15241685
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13466564
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13464095
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.13291590
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12573574
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11003594
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10496638
66* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10242833
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08172530
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05796894
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.04850181
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04607392
71* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04537408
72KDM2B_26808549_Chip-Seq_DND41_Human1.03957417
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03064087
74CTCF_27219007_Chip-Seq_Bcells_Human1.02885596
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.01999383
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.01182747
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00780115
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00336922
79FOXA2_19822575_ChIP-Seq_HepG2_Human0.99871888
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99704264
81MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99668233
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99339370
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98391702
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98263478
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97941313
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97390507
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.97275356
88AHR_22903824_ChIP-Seq_MCF-7_Human0.96043171
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95456496
90* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95234524
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94496124
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94496124
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94144720
94GATA1_19941826_ChIP-Seq_K562_Human0.93514093
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.93480939
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.92812160
97* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92044586
98* EZH2_27304074_Chip-Seq_ESCs_Mouse0.91989492
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91061527
100* TCF7_22412390_ChIP-Seq_EML_Mouse0.90969840
101* TP63_22573176_ChIP-Seq_HFKS_Human0.90880816
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90457016
103AR_21572438_ChIP-Seq_LNCaP_Human0.89872711
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89551943
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89551943
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88363520
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88077624
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88030177
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86891226
110BRD4_25478319_ChIP-Seq_HGPS_Human0.86822040
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86329864
112* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86217597
113* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86069681
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85680516
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85156807
116ATF3_27146783_Chip-Seq_COLON_Human0.84319319
117* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83772746
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83346401
119BCAT_22108803_ChIP-Seq_LS180_Human0.83024993
120SOX2_20726797_ChIP-Seq_SW620_Human0.82734303
121TP53_16413492_ChIP-PET_HCT116_Human0.82599109
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.82028253
123* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81965482
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81640426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen5.46283464
2* MP0005275_abnormal_skin_tensile4.85191635
3MP0002837_dystrophic_cardiac_calcinosis4.60235540
4MP0000751_myopathy4.36687984
5MP0005503_abnormal_tendon_morphology3.42863204
6MP0003705_abnormal_hypodermis_morpholog3.38223498
7MP0005670_abnormal_white_adipose3.36734262
8MP0004084_abnormal_cardiac_muscle2.89223455
9MP0004130_abnormal_muscle_cell2.86827377
10MP0004272_abnormal_basement_membrane2.63833066
11MP0003646_muscle_fatigue2.56984420
12MP0005666_abnormal_adipose_tissue2.56909456
13MP0001958_emphysema2.55962609
14MP0000749_muscle_degeneration2.43039596
15MP0004036_abnormal_muscle_relaxation2.41792336
16MP0000750_abnormal_muscle_regeneration2.39805715
17MP0005330_cardiomyopathy2.37072622
18MP0004215_abnormal_myocardial_fiber2.32145497
19MP0004185_abnormal_adipocyte_glucose2.19868218
20MP0004087_abnormal_muscle_fiber2.15366664
21MP0003279_aneurysm2.02108600
22MP0005375_adipose_tissue_phenotype2.00408827
23MP0002108_abnormal_muscle_morphology1.98729517
24MP0005620_abnormal_muscle_contractility1.80097118
25MP0000013_abnormal_adipose_tissue1.77742609
26MP0002106_abnormal_muscle_physiology1.77156037
27* MP0002060_abnormal_skin_morphology1.76477451
28MP0004145_abnormal_muscle_electrophysio1.70649306
29MP0001544_abnormal_cardiovascular_syste1.68272536
30MP0005385_cardiovascular_system_phenoty1.68272536
31MP0006138_congestive_heart_failure1.67817762
32MP0002972_abnormal_cardiac_muscle1.65503596
33MP0008775_abnormal_heart_ventricle1.65290817
34MP0003566_abnormal_cell_adhesion1.64057292
35MP0005369_muscle_phenotype1.62328314
36MP0000759_abnormal_skeletal_muscle1.61444949
37MP0010368_abnormal_lymphatic_system1.55688755
38MP0010630_abnormal_cardiac_muscle1.53859814
39MP0000747_muscle_weakness1.52244784
40MP0002933_joint_inflammation1.47611289
41MP0000003_abnormal_adipose_tissue1.46373995
42MP0003828_pulmonary_edema1.45281915
43MP0005409_darkened_coat_color1.41262590
44MP0002269_muscular_atrophy1.38144680
45MP0003045_fibrosis1.35340028
46MP0005257_abnormal_intraocular_pressure1.31643266
47MP0004484_altered_response_of1.28578450
48MP0002971_abnormal_brown_adipose1.28110753
49MP0002796_impaired_skin_barrier1.26126780
50MP0001542_abnormal_bone_strength1.25117432
51MP0004858_abnormal_nervous_system1.20325431
52MP0003191_abnormal_cellular_cholesterol1.17417738
53MP0000343_altered_response_to1.16220006
54MP0003950_abnormal_plasma_membrane1.14634837
55MP0001879_abnormal_lymphatic_vessel1.09554761
56MP0003137_abnormal_impulse_conducting1.09405415
57MP0005171_absent_coat_pigmentation1.08249275
58MP0009115_abnormal_fat_cell1.07985256
59MP0006054_spinal_hemorrhage1.07487658
60MP0002295_abnormal_pulmonary_circulatio1.05078685
61MP0000579_abnormal_nail_morphology1.02634375
62MP0000733_abnormal_muscle_development0.99923158
63MP0002254_reproductive_system_inflammat0.97677606
64MP0001243_abnormal_dermal_layer0.95273779
65MP0005508_abnormal_skeleton_morphology0.93855499
66MP0002249_abnormal_larynx_morphology0.93770392
67MP0005623_abnormal_meninges_morphology0.92216309
68MP0001661_extended_life_span0.92033703
69MP0005334_abnormal_fat_pad0.91743747
70MP0004085_abnormal_heartbeat0.90969498
71MP0010329_abnormal_lipoprotein_level0.89889107
72MP0002998_abnormal_bone_remodeling0.89815191
73MP0005164_abnormal_response_to0.88424557
74MP0000767_abnormal_smooth_muscle0.87805879
75MP0004510_myositis0.87208176
76MP0009384_cardiac_valve_regurgitation0.85033950
77MP0009780_abnormal_chondrocyte_physiolo0.81439137
78MP0008004_abnormal_stomach_pH0.78462126
79MP0002128_abnormal_blood_circulation0.77317839
80MP0005390_skeleton_phenotype0.76766298
81MP0001299_abnormal_eye_distance/0.76161427
82MP0000163_abnormal_cartilage_morphology0.75385080
83MP0002168_other_aberrant_phenotype0.74908855
84MP0000266_abnormal_heart_morphology0.74652529
85MP0004233_abnormal_muscle_weight0.74589321
86MP0002332_abnormal_exercise_endurance0.73603908
87MP0002970_abnormal_white_adipose0.72972454
88MP0005165_increased_susceptibility_to0.72887586
89MP0002118_abnormal_lipid_homeostasis0.72786620
90MP0005595_abnormal_vascular_smooth0.69515072
91MP0003879_abnormal_hair_cell0.69441629
92MP0000230_abnormal_systemic_arterial0.69147306
93MP0002133_abnormal_respiratory_system0.68536858
94MP0005388_respiratory_system_phenotype0.68536858
95MP0002896_abnormal_bone_mineralization0.66143797
96MP0004782_abnormal_surfactant_physiolog0.65909352
97MP0005023_abnormal_wound_healing0.65653676
98MP0002234_abnormal_pharynx_morphology0.64264646
99MP0008961_abnormal_basal_metabolism0.63822766
100MP0003221_abnormal_cardiomyocyte_apopto0.62587976
101MP0002115_abnormal_skeleton_extremities0.62519298
102MP0003959_abnormal_lean_body0.62335470
103MP0001849_ear_inflammation0.61347934
104MP0002127_abnormal_cardiovascular_syste0.58397362
105MP0005501_abnormal_skin_physiology0.57383698
106MP0001756_abnormal_urination0.57093160
107MP0001614_abnormal_blood_vessel0.56265397
108MP0003724_increased_susceptibility_to0.56242679
109* MP0010771_integument_phenotype0.54471588
110MP0005076_abnormal_cell_differentiation0.54353268
111MP0005167_abnormal_blood-brain_barrier0.53964394
112MP0003252_abnormal_bile_duct0.53232903
113MP0003567_abnormal_fetal_cardiomyocyte0.53057114
114MP0003091_abnormal_cell_migration0.50886438
115MP0000467_abnormal_esophagus_morphology0.49203058
116MP0000249_abnormal_blood_vessel0.47754772
117MP0005319_abnormal_enzyme/_coenzyme0.47054993

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)6.30525353
2Ankle contracture (HP:0006466)5.53734930
3* Increased connective tissue (HP:0009025)4.96557234
4Broad metatarsal (HP:0001783)4.93491532
5Protrusio acetabuli (HP:0003179)4.79276191
6Increased variability in muscle fiber diameter (HP:0003557)4.55648099
7Sudden death (HP:0001699)4.54750103
8Follicular hyperkeratosis (HP:0007502)4.47903287
9Premature rupture of membranes (HP:0001788)4.43821458
10Right ventricular cardiomyopathy (HP:0011663)4.18500621
11Slender build (HP:0001533)4.15026908
12Hyporeflexia of lower limbs (HP:0002600)4.13290346
13Spinal rigidity (HP:0003306)4.11345057
14Abnormality of skeletal muscle fiber size (HP:0012084)4.09588583
15Aortic dissection (HP:0002647)4.04397122
16Mildly elevated creatine phosphokinase (HP:0008180)4.02575547
17Cerebral aneurysm (HP:0004944)3.99619064
18Ventricular tachycardia (HP:0004756)3.99006217
19Exercise-induced myalgia (HP:0003738)3.78295241
20* Muscle fiber splitting (HP:0003555)3.73483007
21Calf muscle hypertrophy (HP:0008981)3.70071795
22Lipoatrophy (HP:0100578)3.66769608
23Atrophic scars (HP:0001075)3.50349602
24Fragile skin (HP:0001030)3.47046369
25Difficulty running (HP:0009046)3.45716494
26Abnormality of the calf musculature (HP:0001430)3.40622710
27Muscle hypertrophy of the lower extremities (HP:0008968)3.35852228
28Exercise-induced muscle cramps (HP:0003710)3.24635160
29Myoglobinuria (HP:0002913)3.20707894
30Aortic aneurysm (HP:0004942)3.18689957
31Round ear (HP:0100830)3.14160074
32Vascular tortuosity (HP:0004948)3.14038360
33Obstructive sleep apnea (HP:0002870)3.08226106
34Shallow orbits (HP:0000586)3.02915898
35Ulnar deviation of the wrist (HP:0003049)3.02505028
36Atrial fibrillation (HP:0005110)2.97494180
37Cervical subluxation (HP:0003308)2.95352347
38Bladder diverticulum (HP:0000015)2.93031718
39Abnormality of complement system (HP:0005339)2.81575756
40Primary atrial arrhythmia (HP:0001692)2.72972225
41EMG: myopathic abnormalities (HP:0003458)2.71934225
42Myotonia (HP:0002486)2.71843356
43Supraventricular arrhythmia (HP:0005115)2.65002112
44Wrist flexion contracture (HP:0001239)2.61583191
45Supraventricular tachycardia (HP:0004755)2.58622397
46Arterial tortuosity (HP:0005116)2.55145466
47Rectal prolapse (HP:0002035)2.49159802
48Polycythemia (HP:0001901)2.49015276
49Dilated cardiomyopathy (HP:0001644)2.48078915
50Difficulty climbing stairs (HP:0003551)2.47755618
51Aortic regurgitation (HP:0001659)2.46845881
52Subaortic stenosis (HP:0001682)2.46521113
53Abnormality of the left ventricular outflow tract (HP:0011103)2.46521113
54Asymmetric septal hypertrophy (HP:0001670)2.45973786
55Acanthosis nigricans (HP:0000956)2.45470621
56Aneurysm (HP:0002617)2.43840524
57Joint stiffness (HP:0001387)2.43129796
58Pulmonary artery stenosis (HP:0004415)2.41934345
59* Mitral valve prolapse (HP:0001634)2.40241143
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39752394
61Facial diplegia (HP:0001349)2.39474626
62Muscle fiber inclusion bodies (HP:0100299)2.37080765
63Rhabdomyolysis (HP:0003201)2.33407017
64Generalized amyotrophy (HP:0003700)2.33331103
65Limb-girdle muscle weakness (HP:0003325)2.31499291
66Neoplasm of the heart (HP:0100544)2.31053471
67Systemic lupus erythematosus (HP:0002725)2.29897851
68Bundle branch block (HP:0011710)2.29197298
69* Wormian bones (HP:0002645)2.27005446
70* Soft skin (HP:0000977)2.24096290
71Limited hip movement (HP:0008800)2.23962873
72Distal arthrogryposis (HP:0005684)2.21186342
73Alopecia of scalp (HP:0002293)2.20997271
74Aortic valve stenosis (HP:0001650)2.17939139
75Syncope (HP:0001279)2.17507934
76Peritonitis (HP:0002586)2.16876084
77Prolonged QT interval (HP:0001657)2.14900964
78Ventricular arrhythmia (HP:0004308)2.11185445
79Mitral regurgitation (HP:0001653)2.10611566
80Oligomenorrhea (HP:0000876)2.09228112
81Neck muscle weakness (HP:0000467)2.09153471
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.08014686
83Osteolytic defects of the hand bones (HP:0009699)2.08014686
84Testicular atrophy (HP:0000029)2.07857068
85Palpitations (HP:0001962)2.07481766
86* Dilatation of the ascending aorta (HP:0005111)2.06029955
87Ectopia lentis (HP:0001083)2.05149351
88Flat cornea (HP:0007720)2.04221924
89Reduced subcutaneous adipose tissue (HP:0003758)2.02762825
90Lower limb amyotrophy (HP:0007210)2.02303124
91Bronchomalacia (HP:0002780)2.01341144
92Lymphangioma (HP:0100764)2.00464938
93Neonatal short-limb short stature (HP:0008921)1.98492485
94Overgrowth (HP:0001548)1.98399376
95Scapular winging (HP:0003691)1.97596679
96Atrioventricular block (HP:0001678)1.97287882
97* Joint laxity (HP:0001388)1.96797272
98Complement deficiency (HP:0004431)1.96062835
99Abnormal atrioventricular conduction (HP:0005150)1.96043000
100Hypoplasia of the iris (HP:0007676)1.95971087
101Vertebral compression fractures (HP:0002953)1.95658026
102Conjunctival hamartoma (HP:0100780)1.95132266
103Distal lower limb muscle weakness (HP:0009053)1.94426900
104Muscle stiffness (HP:0003552)1.92303679
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.91761995
106Muscular dystrophy (HP:0003560)1.87856349
107Persistence of primary teeth (HP:0006335)1.87575456
108Hypoventilation (HP:0002791)1.87305076
109Nemaline bodies (HP:0003798)1.87252213
110Heart block (HP:0012722)1.87037735
111Thin bony cortex (HP:0002753)1.85381771
112Abnormality of the 4th metacarpal (HP:0010012)1.84846246
113Mitral stenosis (HP:0001718)1.84263594
114Emphysema (HP:0002097)1.84048743
115Wide anterior fontanel (HP:0000260)1.83603975
116Hypertriglyceridemia (HP:0002155)1.83555324
117Elbow flexion contracture (HP:0002987)1.83327082
118Hip contracture (HP:0003273)1.80941429
119Bulbar palsy (HP:0001283)1.80492617
120Distal lower limb amyotrophy (HP:0008944)1.80308286
121Bradycardia (HP:0001662)1.80182183
122Hypoplastic ischia (HP:0003175)1.79761128
123Achilles tendon contracture (HP:0001771)1.79653356
124Foot dorsiflexor weakness (HP:0009027)1.79468514
125Blue sclerae (HP:0000592)1.78322155
126Genu recurvatum (HP:0002816)1.77465677
127Skin nodule (HP:0200036)1.77461123
128Broad face (HP:0000283)1.75160689
129Milia (HP:0001056)1.74955398
130Mesangial abnormality (HP:0001966)1.74856376
131Hypoalphalipoproteinemia (HP:0003233)1.74069309
132Hypoglycemic coma (HP:0001325)1.73955745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.99459319
2TRIB34.40265162
3OBSCN3.03943600
4SIK12.99187496
5LMTK22.79905537
6MYLK2.78625864
7RIPK12.70879164
8CAMK1D2.59883128
9DMPK2.43732829
10TIE12.41258003
11PHKG12.34882514
12PHKG22.34882514
13PKN22.19022210
14ERN12.10062097
15BCKDK2.08764803
16PDK32.08293793
17PDK42.08293793
18PDGFRA2.07645859
19CAMK1G1.98999879
20TGFBR21.95986316
21DDR21.62218529
22PIK3CA1.61473173
23LATS11.61123515
24MST1R1.58754507
25PRPF4B1.46982410
26FGFR41.44096326
27EPHB11.43862658
28FER1.40026570
29PDK21.37009508
30MAPK71.32467875
31EPHB21.25284133
32INSRR1.17233656
33AKT31.13981419
34MAPKAPK31.13171101
35PRKAA21.10176829
36FGFR21.09439309
37MAP3K71.09347731
38PRKD11.05413045
39KIT1.02537567
40PTK61.01477258
41FGFR30.98229656
42EPHA30.96011326
43MAP3K30.95292052
44MAPK40.94001442
45MAP2K30.93624278
46ILK0.92724066
47MET0.86844881
48TESK10.86806133
49PIK3CG0.84633257
50ROCK10.82482482
51PDGFRB0.81026810
52JAK10.80786043
53PRKCH0.78681380
54PTK2B0.78591411
55HIPK20.77668692
56SGK20.77559063
57PAK20.76808395
58SGK30.76027390
59SGK2230.73390178
60SGK4940.73390178
61NLK0.72636967
62EEF2K0.72491635
63PRKAA10.71455305
64TRPM70.71062560
65MTOR0.70736130
66LATS20.70450878
67PINK10.70360705
68MAPK120.68433688
69GRK50.67217432
70NTRK10.66565569
71RET0.63883991
72ICK0.60449932
73PAK30.59971860
74ABL20.55580649
75FRK0.55479304
76FGFR10.55055002
77BMX0.54970517
78MAPK150.54665418
79MAP2K10.53992598
80CDC42BPA0.53206471
81KDR0.53041357
82NEK90.52313455
83MAP3K10.52104527
84ROCK20.50984455
85CSK0.50916024
86MAP3K60.50745448
87MUSK0.50178243
88LRRK20.49443874
89MAPKAPK50.49379486
90ADRBK10.49251702
91PDPK10.47579247
92PRKD30.47388467
93CAMK2G0.46677041
94PTK20.45996153
95GSK3A0.45891841
96JAK20.45436741
97DAPK30.45194101
98BLK0.43755616
99NEK10.43559358
100STK380.42068465
101MARK20.41497515
102PRKD20.41397988
103MAP3K100.41370501
104MARK10.41311396
105FLT30.41245551
106STK240.41233910
107MAPK30.41211832
108CAMK2D0.39792983
109EPHA20.38878899
110MAPK10.38638035
111PAK40.38463985
112PRKG10.37990902
113RPS6KA20.37220890
114ZAP700.36732994
115PRKACG0.36660008
116PRKG20.36512502
117CAMK40.36390938
118RPS6KC10.36153125
119RPS6KL10.36153125
120WNK10.35744654
121RPS6KA60.31419407
122CAMK10.30956002
123PKN10.30725643
124STK30.28890753
125MAPK110.28586272
126TAOK10.28418310
127DAPK20.25839274
128SRC0.25810440
129PDK10.24385971

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.63197281
2Propanoate metabolism_Homo sapiens_hsa006403.02825760
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83651970
4* ECM-receptor interaction_Homo sapiens_hsa045122.83376389
5Fatty acid degradation_Homo sapiens_hsa000712.63972653
6Dilated cardiomyopathy_Homo sapiens_hsa054142.57303086
7PPAR signaling pathway_Homo sapiens_hsa033202.55122607
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.52941673
9Fatty acid metabolism_Homo sapiens_hsa012122.44988413
10Fatty acid biosynthesis_Homo sapiens_hsa000612.41967799
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.33392142
12Protein digestion and absorption_Homo sapiens_hsa049742.32775548
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26598858
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02857866
15* Focal adhesion_Homo sapiens_hsa045101.85715944
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.73043005
17Insulin resistance_Homo sapiens_hsa049311.58316619
18Carbon metabolism_Homo sapiens_hsa012001.47889314
19Cardiac muscle contraction_Homo sapiens_hsa042601.47651011
20Pyruvate metabolism_Homo sapiens_hsa006201.46029411
21Amoebiasis_Homo sapiens_hsa051461.42191372
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40503663
23Viral myocarditis_Homo sapiens_hsa054161.39790226
24AMPK signaling pathway_Homo sapiens_hsa041521.31071494
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.29160759
26Nitrogen metabolism_Homo sapiens_hsa009101.23536403
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.22084803
28Caffeine metabolism_Homo sapiens_hsa002321.19935473
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16606975
30Insulin signaling pathway_Homo sapiens_hsa049101.15860893
31Glycerolipid metabolism_Homo sapiens_hsa005611.13182963
32beta-Alanine metabolism_Homo sapiens_hsa004101.11513708
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02375211
34Glucagon signaling pathway_Homo sapiens_hsa049221.01516510
35Fat digestion and absorption_Homo sapiens_hsa049751.00454690
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00380739
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98183651
38Butanoate metabolism_Homo sapiens_hsa006500.97153746
39Proteoglycans in cancer_Homo sapiens_hsa052050.94442333
40Histidine metabolism_Homo sapiens_hsa003400.92059277
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91069882
42Tryptophan metabolism_Homo sapiens_hsa003800.90447091
43Starch and sucrose metabolism_Homo sapiens_hsa005000.89382976
44Gap junction_Homo sapiens_hsa045400.89013075
45Lysine degradation_Homo sapiens_hsa003100.88297615
46Small cell lung cancer_Homo sapiens_hsa052220.87590520
47Arginine biosynthesis_Homo sapiens_hsa002200.86588429
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85475678
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85322567
50Renin secretion_Homo sapiens_hsa049240.84191068
51Adherens junction_Homo sapiens_hsa045200.83744621
52Type II diabetes mellitus_Homo sapiens_hsa049300.83271380
53Fatty acid elongation_Homo sapiens_hsa000620.82782271
54Phenylalanine metabolism_Homo sapiens_hsa003600.82198024
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.81097241
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76602214
57Complement and coagulation cascades_Homo sapiens_hsa046100.76356422
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75449044
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73321273
60Pertussis_Homo sapiens_hsa051330.73003902
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72617689
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.71661520
63Toxoplasmosis_Homo sapiens_hsa051450.69133467
64* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66884827
65Choline metabolism in cancer_Homo sapiens_hsa052310.65680111
66Platelet activation_Homo sapiens_hsa046110.65668879
67Glioma_Homo sapiens_hsa052140.65347378
68Malaria_Homo sapiens_hsa051440.65281691
69Axon guidance_Homo sapiens_hsa043600.64926237
70Basal cell carcinoma_Homo sapiens_hsa052170.62853253
71ABC transporters_Homo sapiens_hsa020100.62581498
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62434248
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62294339
74Staphylococcus aureus infection_Homo sapiens_hsa051500.62038674
75Circadian entrainment_Homo sapiens_hsa047130.61748593
76Long-term potentiation_Homo sapiens_hsa047200.61111760
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61042650
78Other glycan degradation_Homo sapiens_hsa005110.61014110
79Tight junction_Homo sapiens_hsa045300.58354659
80Bile secretion_Homo sapiens_hsa049760.57936811
81Tyrosine metabolism_Homo sapiens_hsa003500.57273594
82Peroxisome_Homo sapiens_hsa041460.57138448
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.56504019
84MAPK signaling pathway_Homo sapiens_hsa040100.55083281
85Dorso-ventral axis formation_Homo sapiens_hsa043200.54599000
86Insulin secretion_Homo sapiens_hsa049110.54523834
87Ras signaling pathway_Homo sapiens_hsa040140.54402186
88HIF-1 signaling pathway_Homo sapiens_hsa040660.52105100
89Chronic myeloid leukemia_Homo sapiens_hsa052200.52076056
90Prolactin signaling pathway_Homo sapiens_hsa049170.51150405
91Pancreatic secretion_Homo sapiens_hsa049720.50349600
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48931633
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47800591
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.47636941
95Melanoma_Homo sapiens_hsa052180.47486970
96cAMP signaling pathway_Homo sapiens_hsa040240.47281684
97Gastric acid secretion_Homo sapiens_hsa049710.47023649
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.46412348
99FoxO signaling pathway_Homo sapiens_hsa040680.45743279
100Oxytocin signaling pathway_Homo sapiens_hsa049210.45306892
101Notch signaling pathway_Homo sapiens_hsa043300.44507061
102Cholinergic synapse_Homo sapiens_hsa047250.43916839
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43509498
104Prion diseases_Homo sapiens_hsa050200.42928516
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42690788
106Biosynthesis of amino acids_Homo sapiens_hsa012300.41874603
107* MicroRNAs in cancer_Homo sapiens_hsa052060.41653574
108Prostate cancer_Homo sapiens_hsa052150.41318003
109Estrogen signaling pathway_Homo sapiens_hsa049150.38511900
110Acute myeloid leukemia_Homo sapiens_hsa052210.37267598
111mTOR signaling pathway_Homo sapiens_hsa041500.36935532
112Hedgehog signaling pathway_Homo sapiens_hsa043400.36417943
113Pathways in cancer_Homo sapiens_hsa052000.35904028
114Calcium signaling pathway_Homo sapiens_hsa040200.35871348
115VEGF signaling pathway_Homo sapiens_hsa043700.33907208
116Ovarian steroidogenesis_Homo sapiens_hsa049130.32676041
117GnRH signaling pathway_Homo sapiens_hsa049120.30596094
118Renin-angiotensin system_Homo sapiens_hsa046140.30263113
119Circadian rhythm_Homo sapiens_hsa047100.28736758
120TGF-beta signaling pathway_Homo sapiens_hsa043500.27791782
121Alzheimers disease_Homo sapiens_hsa050100.27697664
122Melanogenesis_Homo sapiens_hsa049160.25592015
123Renal cell carcinoma_Homo sapiens_hsa052110.25531200
124Rap1 signaling pathway_Homo sapiens_hsa040150.25228240
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.25113654
126Salivary secretion_Homo sapiens_hsa049700.23755043
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23297789
128Thyroid hormone synthesis_Homo sapiens_hsa049180.22954116

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