TOB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)6.69171596
2intestinal epithelial cell development (GO:0060576)5.95700871
3negative regulation of JUN kinase activity (GO:0043508)5.85916350
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.83787623
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.79779202
6L-phenylalanine catabolic process (GO:0006559)5.79779202
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.37785436
8L-phenylalanine metabolic process (GO:0006558)5.37785436
9aromatic amino acid family catabolic process (GO:0009074)4.74029848
10RNA destabilization (GO:0050779)4.50013434
11protein K11-linked deubiquitination (GO:0035871)4.43273223
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.31115738
13regulation of T cell receptor signaling pathway (GO:0050856)4.24543533
14intestinal cholesterol absorption (GO:0030299)4.23765808
15cysteine metabolic process (GO:0006534)4.18372144
16alpha-linolenic acid metabolic process (GO:0036109)4.18080310
17sulfur amino acid catabolic process (GO:0000098)4.02923353
18lactate metabolic process (GO:0006089)4.00017296
19bile acid biosynthetic process (GO:0006699)3.93136239
20indole-containing compound catabolic process (GO:0042436)3.90074899
21indolalkylamine catabolic process (GO:0046218)3.90074899
22tryptophan catabolic process (GO:0006569)3.90074899
23negative regulation of acute inflammatory response (GO:0002674)3.87451579
24regulation of triglyceride catabolic process (GO:0010896)3.87357102
25glyoxylate metabolic process (GO:0046487)3.83772052
26platelet dense granule organization (GO:0060155)3.79966991
27DNA deamination (GO:0045006)3.75659155
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.75210121
29high-density lipoprotein particle remodeling (GO:0034375)3.73492598
30regulation of hexokinase activity (GO:1903299)3.72434558
31regulation of glucokinase activity (GO:0033131)3.72434558
32tryptophan metabolic process (GO:0006568)3.71320515
33kynurenine metabolic process (GO:0070189)3.71201577
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.69899549
35regulation of respiratory burst (GO:0060263)3.66614492
36regulation of bile acid biosynthetic process (GO:0070857)3.65362054
37protein carboxylation (GO:0018214)3.59652854
38peptidyl-glutamic acid carboxylation (GO:0017187)3.59652854
39triglyceride homeostasis (GO:0070328)3.52257345
40acylglycerol homeostasis (GO:0055090)3.52257345
41positive regulation of protein autophosphorylation (GO:0031954)3.51955528
42lysine metabolic process (GO:0006553)3.50975581
43lysine catabolic process (GO:0006554)3.50975581
44CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.50401564
45T-helper cell differentiation (GO:0042093)3.50401564
46urea cycle (GO:0000050)3.45719108
47urea metabolic process (GO:0019627)3.45719108
48bile acid metabolic process (GO:0008206)3.44806497
49regulation of protein glycosylation (GO:0060049)3.44210361
50reverse cholesterol transport (GO:0043691)3.43453612
51amino-acid betaine metabolic process (GO:0006577)3.41256458
52tyrosine metabolic process (GO:0006570)3.39454752
53regulation of cholesterol esterification (GO:0010872)3.38385614
54regulation of cholesterol homeostasis (GO:2000188)3.35745904
55regulation of fibroblast apoptotic process (GO:2000269)3.35105002
56homocysteine metabolic process (GO:0050667)3.34216884
57cellular glucuronidation (GO:0052695)3.34089659
58aromatic amino acid family metabolic process (GO:0009072)3.33163517
59short-chain fatty acid metabolic process (GO:0046459)3.32789981
60fibroblast migration (GO:0010761)3.30375121
61molting cycle (GO:0042303)3.28549241
62hair cycle (GO:0042633)3.28549241
63fatty acid beta-oxidation (GO:0006635)3.27601770
64cellular ketone body metabolic process (GO:0046950)3.26220334
65alpha-amino acid catabolic process (GO:1901606)3.25540865
66complement activation, alternative pathway (GO:0006957)3.23804479
67protein-lipid complex remodeling (GO:0034368)3.22464636
68macromolecular complex remodeling (GO:0034367)3.22464636
69plasma lipoprotein particle remodeling (GO:0034369)3.22464636
70fatty acid oxidation (GO:0019395)3.20979157
71* positive regulation of mRNA catabolic process (GO:0061014)3.20276799
72ethanol oxidation (GO:0006069)3.19918984
73nitrogen cycle metabolic process (GO:0071941)3.19862656
74phospholipid efflux (GO:0033700)3.18808383
75regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.18095608
76cellular modified amino acid catabolic process (GO:0042219)3.17254440
77lipid oxidation (GO:0034440)3.16515142
78response to nitrosative stress (GO:0051409)3.15805651
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.14593486
80hepatocyte apoptotic process (GO:0097284)3.13613533
81serine family amino acid catabolic process (GO:0009071)3.13167805
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12887651
83valine metabolic process (GO:0006573)3.12489294
84cellular amino acid catabolic process (GO:0009063)3.12100706
85regulation of protein activation cascade (GO:2000257)3.12040537
86coenzyme catabolic process (GO:0009109)3.11945130
87fatty acid catabolic process (GO:0009062)3.11696044
88negative regulation of B cell activation (GO:0050869)3.10418120
89respiratory chain complex IV assembly (GO:0008535)3.09749936
90drug transmembrane transport (GO:0006855)3.07506613
91drug catabolic process (GO:0042737)3.07209253
92alpha-beta T cell differentiation involved in immune response (GO:0002293)3.06256417
93alpha-beta T cell activation involved in immune response (GO:0002287)3.06256417
94T cell differentiation involved in immune response (GO:0002292)3.06256417
95aspartate family amino acid catabolic process (GO:0009068)3.05526626
96negative regulation of fibrinolysis (GO:0051918)3.05393266
97uronic acid metabolic process (GO:0006063)3.05070714
98glucuronate metabolic process (GO:0019585)3.05070714
99plasma lipoprotein particle clearance (GO:0034381)3.04713488
100regulation of fibrinolysis (GO:0051917)3.04667286
101ER overload response (GO:0006983)3.04602834
102negative regulation of lipase activity (GO:0060192)3.04517046
103cholesterol efflux (GO:0033344)3.03175532
104intestinal absorption (GO:0050892)3.02722619
105positive regulation of fatty acid beta-oxidation (GO:0032000)3.02315569
106monocarboxylic acid catabolic process (GO:0072329)3.01191067
107axoneme assembly (GO:0035082)3.00638162
108positive regulation of lipoprotein lipase activity (GO:0051006)3.00506158
109positive regulation of triglyceride lipase activity (GO:0061365)3.00506158
110glutamate metabolic process (GO:0006536)2.99662381
111S-adenosylmethionine metabolic process (GO:0046500)2.99486633
112regulation of cholesterol metabolic process (GO:0090181)2.98800883
113acetyl-CoA metabolic process (GO:0006084)2.97285670
114benzene-containing compound metabolic process (GO:0042537)2.96499785
115positive regulation of lipid catabolic process (GO:0050996)2.95343483
116regulation of acrosome reaction (GO:0060046)2.94947313
117very long-chain fatty acid metabolic process (GO:0000038)2.94874204
118regulation of complement activation (GO:0030449)2.93820848
119cholesterol homeostasis (GO:0042632)2.92918681
120carboxylic acid catabolic process (GO:0046395)2.92665799
121organic acid catabolic process (GO:0016054)2.92665799
122branched-chain amino acid catabolic process (GO:0009083)2.92588896
123bile acid and bile salt transport (GO:0015721)2.92523653
124negative regulation of B cell proliferation (GO:0030889)2.91994796
125* regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.91622644
126* positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.91622644
127flavonoid metabolic process (GO:0009812)2.89674231
128nucleotide transmembrane transport (GO:1901679)2.89481964
129sterol homeostasis (GO:0055092)2.89335595
130regulation of cholesterol biosynthetic process (GO:0045540)2.89098273
131endocrine pancreas development (GO:0031018)2.87957516
132detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87581043
133negative regulation of cholesterol transport (GO:0032375)2.85915620
134negative regulation of sterol transport (GO:0032372)2.85915620
135xenobiotic catabolic process (GO:0042178)2.83874463
136detection of light stimulus involved in sensory perception (GO:0050962)2.82960175
137detection of light stimulus involved in visual perception (GO:0050908)2.82960175
138very-low-density lipoprotein particle assembly (GO:0034379)2.81679022
139transcytosis (GO:0045056)2.81245934
140negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81195104
141ketone body metabolic process (GO:1902224)2.81114149
142branched-chain amino acid metabolic process (GO:0009081)2.80250937
143indolalkylamine metabolic process (GO:0006586)2.79639814
144carnitine metabolic process (GO:0009437)2.79639567
145biotin metabolic process (GO:0006768)2.79152569
146auditory receptor cell stereocilium organization (GO:0060088)2.77396046
147positive regulation of fatty acid oxidation (GO:0046321)2.76599215
148alpha-beta T cell differentiation (GO:0046632)2.72261810
149signal peptide processing (GO:0006465)2.66451348
150positive regulation of glycoprotein metabolic process (GO:1903020)2.65006699
151female gonad development (GO:0008585)2.64946570
152cytochrome complex assembly (GO:0017004)2.63826456
153positive regulation of glycolytic process (GO:0045821)2.63457293
154CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.56813203
155regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.55597936
156photoreceptor cell development (GO:0042461)2.54324855
157eye photoreceptor cell development (GO:0042462)2.52409323
158cytidine deamination (GO:0009972)2.51669213
159cytidine metabolic process (GO:0046087)2.51669213
160cytidine catabolic process (GO:0006216)2.51669213
161regulation of protein autophosphorylation (GO:0031952)2.51310251
162cellular response to interleukin-15 (GO:0071350)2.49280942
163regulation of memory T cell differentiation (GO:0043380)2.47708469
164protein localization to cilium (GO:0061512)2.46085081
165regulation of type B pancreatic cell apoptotic process (GO:2000674)2.45121980
166preassembly of GPI anchor in ER membrane (GO:0016254)2.44152496
167inositol phosphate catabolic process (GO:0071545)2.43926219
168multicellular organism reproduction (GO:0032504)2.43305042
169water-soluble vitamin biosynthetic process (GO:0042364)2.42585219
170neural tube formation (GO:0001841)2.41429004
171polyol catabolic process (GO:0046174)2.40753232
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.39758018
173regulation of translation, ncRNA-mediated (GO:0045974)2.39758018
174negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39758018
175* regulation of mRNA catabolic process (GO:0061013)2.36259854
176negative regulation of neurological system process (GO:0031645)2.35809556
177regulation of relaxation of muscle (GO:1901077)2.35538520
178alpha-beta T cell activation (GO:0046631)2.34943229
179retinal metabolic process (GO:0042574)2.34745956
180transepithelial transport (GO:0070633)2.34697057
181zinc ion transport (GO:0006829)2.32186120
182regulation of autophagic vacuole assembly (GO:2000785)2.32008745
183negative regulation of signal transduction by p53 class mediator (GO:1901797)2.31334026
184negative T cell selection (GO:0043383)2.30337441
185estrogen metabolic process (GO:0008210)2.30212958
186fucose catabolic process (GO:0019317)2.28349607
187L-fucose metabolic process (GO:0042354)2.28349607
188L-fucose catabolic process (GO:0042355)2.28349607
189cellular response to glucocorticoid stimulus (GO:0071385)2.28315060
190embryonic epithelial tube formation (GO:0001838)2.27940564
191piRNA metabolic process (GO:0034587)2.27931944
192negative regulation of T cell receptor signaling pathway (GO:0050860)2.26524014
193regulation of meiosis I (GO:0060631)2.25883739
194C-terminal protein lipidation (GO:0006501)2.25533593
195positive regulation of organelle assembly (GO:1902117)2.24517931
196adaptation of signaling pathway (GO:0023058)2.24454744
197negative regulation of execution phase of apoptosis (GO:1900118)2.23467222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38145955
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.84571902
3* LXR_22158963_ChIP-Seq_LIVER_Mouse4.14406285
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14194889
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70228295
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41523937
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.37500234
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37401721
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.10887184
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71506285
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55069612
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.52840267
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45126553
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.44359287
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43574918
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27191129
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17714925
18ER_23166858_ChIP-Seq_MCF-7_Human2.14168510
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10599185
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.07625372
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.07483955
22ZNF274_21170338_ChIP-Seq_K562_Hela1.97159775
23CLOCK_20551151_ChIP-Seq_293T_Human1.92175976
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.88544933
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.88024251
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85232731
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.78669735
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.77283210
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76325007
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74364126
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72241529
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.70425375
33P300_19829295_ChIP-Seq_ESCs_Human1.68927348
34* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68835257
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.68542454
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.67442193
37IGF1R_20145208_ChIP-Seq_DFB_Human1.63984007
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63588586
39ELK1_19687146_ChIP-ChIP_HELA_Human1.59190703
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56293508
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55272879
42FUS_26573619_Chip-Seq_HEK293_Human1.55270369
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.54986532
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47545817
45EWS_26573619_Chip-Seq_HEK293_Human1.45692740
46VDR_23849224_ChIP-Seq_CD4+_Human1.45493368
47TAF15_26573619_Chip-Seq_HEK293_Human1.45395149
48CDX2_22108803_ChIP-Seq_LS180_Human1.45107645
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.44826765
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44575588
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44499664
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41913274
53* NANOG_19829295_ChIP-Seq_ESCs_Human1.41905144
54* SOX2_19829295_ChIP-Seq_ESCs_Human1.41905144
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41620846
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39965628
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39851387
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39851387
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39014172
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.38916633
61* GATA3_26560356_Chip-Seq_TH2_Human1.38429545
62TCF4_22108803_ChIP-Seq_LS180_Human1.38157013
63GBX2_23144817_ChIP-Seq_PC3_Human1.37336040
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37192280
65* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36287709
66RUNX_20019798_ChIP-Seq_JUKART_Human1.34764610
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31310350
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27195476
69CBP_20019798_ChIP-Seq_JUKART_Human1.27195476
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26681790
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26345117
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.24980640
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.24793866
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24158507
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22973209
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22718286
77* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22408201
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21971640
79P53_22387025_ChIP-Seq_ESCs_Mouse1.21633502
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19683509
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.19631525
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19373509
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19366538
84GATA4_25053715_ChIP-Seq_YYC3_Human1.19262305
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.19260736
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.18904882
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18637879
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18612040
89SALL4_22934838_ChIP-ChIP_CD34+_Human1.18237387
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17206852
91SMAD4_21799915_ChIP-Seq_A2780_Human1.16993398
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16424910
93SOX2_20726797_ChIP-Seq_SW620_Human1.15682064
94AR_25329375_ChIP-Seq_VCAP_Human1.14883265
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14860539
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14404289
97AR_21572438_ChIP-Seq_LNCaP_Human1.14345252
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.13939367
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.13323572
100* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.12641957
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.12596435
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12320155
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12112978
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11957304
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11650781
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11224158
107HOXB7_26014856_ChIP-Seq_BT474_Human1.10831532
108P300_18555785_Chip-Seq_ESCs_Mouse1.09442430
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07313264
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07070501
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.07066793
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.05770493
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05296041
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04507241
115TP53_22573176_ChIP-Seq_HFKS_Human1.03543372
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.03152549
117* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02855211
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02718170
119GATA3_27048872_Chip-Seq_THYMUS_Human1.02345015
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02235657
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01327615
122* CDX2_20551321_ChIP-Seq_CACO-2_Human0.99877615
123CJUN_26792858_Chip-Seq_BT549_Human0.99870673
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97107286
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.96715308
126AHR_22903824_ChIP-Seq_MCF-7_Human0.94656717
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91021179
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.90133704
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89970489
130BCAT_22108803_ChIP-Seq_LS180_Human0.88886894
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88781822
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87902473
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.87345523
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.87345523
135TP63_23658742_ChIP-Seq_EP156T_Human0.86250730
136RXR_22108803_ChIP-Seq_LS180_Human0.85367596
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.84414042
138* TP53_18474530_ChIP-ChIP_U2OS_Human0.84068118
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83522532
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82991101
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.82949369
142* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82890895
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82129064
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80583443
145HTT_18923047_ChIP-ChIP_STHdh_Human0.80423655
146VDR_22108803_ChIP-Seq_LS180_Human0.80405790
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79042452
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78856963
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77845942
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77332727
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76865636
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76265308
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75369873
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74814373
155* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74406604
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.74399187
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74192854
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73466708
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72116766
160SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69608204
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68472959
162ZNF263_19887448_ChIP-Seq_K562_Human0.67605836
163* SMAD4_21741376_ChIP-Seq_HESCs_Human0.67553757
164AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67458999
165TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67333468
166RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67152963
167* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66617148
168SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.66148160
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65700547
170EGR1_19032775_ChIP-ChIP_M12_Human0.65479636
171GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64377440
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.63859664
173EED_16625203_ChIP-ChIP_MESCs_Mouse0.63628179
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62754071
175EZH2_27294783_Chip-Seq_ESCs_Mouse0.62365333
176* GATA6_25053715_ChIP-Seq_YYC3_Human0.62365061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.29591952
2MP0005360_urolithiasis5.86500563
3MP0005085_abnormal_gallbladder_physiolo5.07459833
4MP0005365_abnormal_bile_salt4.93685546
5MP0008875_abnormal_xenobiotic_pharmacok4.09761868
6MP0001666_abnormal_nutrient_absorption3.25307797
7MP0000427_abnormal_hair_cycle3.08116474
8MP0003252_abnormal_bile_duct3.05422529
9MP0003806_abnormal_nucleotide_metabolis2.98042382
10MP0003195_calcinosis2.95354728
11MP0005083_abnormal_biliary_tract2.90470308
12MP0002009_preneoplasia2.82965558
13MP0010329_abnormal_lipoprotein_level2.76938885
14MP0003787_abnormal_imprinting2.76437894
15MP0002163_abnormal_gland_morphology2.69915565
16MP0002166_altered_tumor_susceptibility2.55359965
17MP0008877_abnormal_DNA_methylation2.47958693
18MP0005332_abnormal_amino_acid2.43504542
19MP0000372_irregular_coat_pigmentation2.39430349
20MP0005379_endocrine/exocrine_gland_phen2.36303116
21MP0008995_early_reproductive_senescence2.22006893
22MP0004019_abnormal_vitamin_homeostasis2.13000978
23MP0009840_abnormal_foam_cell2.09346423
24MP0002118_abnormal_lipid_homeostasis2.07983425
25MP0005075_abnormal_melanosome_morpholog2.07679217
26MP0008872_abnormal_physiological_respon1.90742757
27MP0001919_abnormal_reproductive_system1.90519667
28MP0005645_abnormal_hypothalamus_physiol1.89159380
29MP0004043_abnormal_pH_regulation1.74910953
30MP0006072_abnormal_retinal_apoptosis1.72657586
31MP0008057_abnormal_DNA_replication1.72070123
32MP0001501_abnormal_sleep_pattern1.71947532
33MP0002254_reproductive_system_inflammat1.68783357
34MP0003786_premature_aging1.68326158
35MP0003868_abnormal_feces_composition1.62029967
36MP0002006_tumorigenesis1.58820413
37MP0005551_abnormal_eye_electrophysiolog1.57171433
38MP0002638_abnormal_pupillary_reflex1.56373568
39MP0000609_abnormal_liver_physiology1.56323600
40MP0005646_abnormal_pituitary_gland1.52660329
41MP0002796_impaired_skin_barrier1.52291607
42MP0002138_abnormal_hepatobiliary_system1.49366806
43MP0002102_abnormal_ear_morphology1.48513647
44MP0001502_abnormal_circadian_rhythm1.48269027
45MP0001984_abnormal_olfaction1.44564260
46MP0004130_abnormal_muscle_cell1.41687622
47MP0009643_abnormal_urine_homeostasis1.41590474
48MP0003191_abnormal_cellular_cholesterol1.40326181
49MP0005389_reproductive_system_phenotype1.39226156
50MP0005671_abnormal_response_to1.38356728
51MP0002148_abnormal_hypersensitivity_rea1.36877294
52MP0005319_abnormal_enzyme/_coenzyme1.36426514
53MP0005670_abnormal_white_adipose1.35227283
54MP0002277_abnormal_respiratory_mucosa1.34460501
55MP0005253_abnormal_eye_physiology1.33819125
56MP0005451_abnormal_body_composition1.29668752
57MP0006054_spinal_hemorrhage1.24650631
58MP0005367_renal/urinary_system_phenotyp1.24405531
59MP0000516_abnormal_urinary_system1.24405531
60MP0002938_white_spotting1.22387290
61MP0002693_abnormal_pancreas_physiology1.20097509
62MP0005000_abnormal_immune_tolerance1.19575189
63MP0005584_abnormal_enzyme/coenzyme_acti1.18318600
64MP0005084_abnormal_gallbladder_morpholo1.17729168
65MP0003705_abnormal_hypodermis_morpholog1.17577201
66MP0005220_abnormal_exocrine_pancreas1.17385361
67MP0003763_abnormal_thymus_physiology1.16927665
68MP0002837_dystrophic_cardiac_calcinosis1.16608514
69MP0002971_abnormal_brown_adipose1.13933690
70MP0009384_cardiac_valve_regurgitation1.12980384
71MP0005174_abnormal_tail_pigmentation1.11053985
72MP0010234_abnormal_vibrissa_follicle1.10074716
73MP0009333_abnormal_splenocyte_physiolog1.08394305
74MP0000569_abnormal_digit_pigmentation1.07236575
75MP0001243_abnormal_dermal_layer1.06004612
76MP0005647_abnormal_sex_gland1.04529848
77MP0005666_abnormal_adipose_tissue1.04387338
78MP0001764_abnormal_homeostasis1.04014638
79MP0000579_abnormal_nail_morphology1.03884715
80MP0003011_delayed_dark_adaptation1.01155458
81MP0002078_abnormal_glucose_homeostasis0.99806556
82MP0000013_abnormal_adipose_tissue0.98868696
83MP0009785_altered_susceptibility_to0.96464528
84MP0003690_abnormal_glial_cell0.95517661
85MP0002060_abnormal_skin_morphology0.94516107
86MP0005408_hypopigmentation0.94497088
87MP0005636_abnormal_mineral_homeostasis0.93782157
88MP0005410_abnormal_fertilization0.93169781
89MP0003183_abnormal_peptide_metabolism0.93103917
90MP0004185_abnormal_adipocyte_glucose0.93027891
91MP0003186_abnormal_redox_activity0.92114630
92MP0005334_abnormal_fat_pad0.92008942
93MP0010368_abnormal_lymphatic_system0.90653434
94MP0001853_heart_inflammation0.90224491
95MP0001346_abnormal_lacrimal_gland0.89557382
96MP0004381_abnormal_hair_follicle0.89549092
97MP0002098_abnormal_vibrissa_morphology0.87394794
98MP0005375_adipose_tissue_phenotype0.87037114
99MP0005310_abnormal_salivary_gland0.86603612
100MP0003950_abnormal_plasma_membrane0.80580694
101MP0005535_abnormal_body_temperature0.79860362
102MP0009780_abnormal_chondrocyte_physiolo0.79837896
103MP0002557_abnormal_social/conspecific_i0.79387450
104MP0001929_abnormal_gametogenesis0.78455999
105MP0002160_abnormal_reproductive_system0.78274111
106MP0001765_abnormal_ion_homeostasis0.77706841
107MP0001661_extended_life_span0.77579159
108MP0002928_abnormal_bile_duct0.76933368
109MP0002876_abnormal_thyroid_physiology0.76714322
110MP0003943_abnormal_hepatobiliary_system0.76455889
111MP0004264_abnormal_extraembryonic_tissu0.76132335
112MP0000653_abnormal_sex_gland0.75353909
113MP0001756_abnormal_urination0.75348224
114MP0003453_abnormal_keratinocyte_physiol0.75065292
115MP0000230_abnormal_systemic_arterial0.74700482
116MP0003724_increased_susceptibility_to0.73566353
117MP0005275_abnormal_skin_tensile0.73434589
118MP0000647_abnormal_sebaceous_gland0.73064724
119MP0005448_abnormal_energy_balance0.72440591
120MP0001485_abnormal_pinna_reflex0.72380459
121MP0000383_abnormal_hair_follicle0.72260177
122MP0004782_abnormal_surfactant_physiolog0.72028148
123MP0000003_abnormal_adipose_tissue0.71042221
124MP0002896_abnormal_bone_mineralization0.70551518
125MP0002909_abnormal_adrenal_gland0.70030425
126MP0010678_abnormal_skin_adnexa0.69682585
127MP0001119_abnormal_female_reproductive0.68403248
128MP0001944_abnormal_pancreas_morphology0.68102895
129MP0003329_amyloid_beta_deposits0.67916784
130MP0002090_abnormal_vision0.67025849
131MP0003878_abnormal_ear_physiology0.65731110
132MP0005377_hearing/vestibular/ear_phenot0.65731110
133MP0000538_abnormal_urinary_bladder0.65455778
134MP0000566_synostosis0.65346960
135MP0000749_muscle_degeneration0.65181651
136MP0003959_abnormal_lean_body0.64427126
137MP0009764_decreased_sensitivity_to0.64055233
138MP0001873_stomach_inflammation0.63971123
139MP0000467_abnormal_esophagus_morphology0.63971101
140MP0009642_abnormal_blood_homeostasis0.63373098
141MP0005248_abnormal_Harderian_gland0.62910952
142MP0001881_abnormal_mammary_gland0.61360901
143MP0003656_abnormal_erythrocyte_physiolo0.59894214
144MP0000613_abnormal_salivary_gland0.59321366
145MP0001800_abnormal_humoral_immune0.59181284
146MP0000920_abnormal_myelination0.58892524
147MP0008961_abnormal_basal_metabolism0.58853680
148MP0000762_abnormal_tongue_morphology0.58780548
149MP0000598_abnormal_liver_morphology0.57958133
150MP0003300_gastrointestinal_ulcer0.57941991
151MP0003953_abnormal_hormone_level0.57597404
152MP0000377_abnormal_hair_follicle0.57142354
153MP0000604_amyloidosis0.56332921
154MP0002136_abnormal_kidney_physiology0.56272077
155MP0005330_cardiomyopathy0.55293059
156MP0009697_abnormal_copulation0.54554887
157MP0000747_muscle_weakness0.54299770
158MP0002108_abnormal_muscle_morphology0.54081181
159MP0005501_abnormal_skin_physiology0.53421437
160MP0006036_abnormal_mitochondrial_physio0.53265363
161MP0000639_abnormal_adrenal_gland0.52808550

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77942642
2Intrahepatic cholestasis (HP:0001406)5.63742541
3Xanthomatosis (HP:0000991)4.90303820
4Metaphyseal dysplasia (HP:0100255)4.80144837
5Deep venous thrombosis (HP:0002625)4.79275286
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.41920914
7Hypoglycemic coma (HP:0001325)4.36616467
8Prolonged partial thromboplastin time (HP:0003645)4.19802150
9Hypothermia (HP:0002045)4.13022297
10Hyperlipoproteinemia (HP:0010980)4.08470680
11Ketosis (HP:0001946)4.01843897
12Epidermoid cyst (HP:0200040)3.90398120
13Hyperglycinuria (HP:0003108)3.88793330
14Hypobetalipoproteinemia (HP:0003563)3.88382883
15Ketoacidosis (HP:0001993)3.72228521
16Fat malabsorption (HP:0002630)3.70114938
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65978458
18Abnormality of serine family amino acid metabolism (HP:0010894)3.63464702
19Abnormality of glycine metabolism (HP:0010895)3.63464702
20Hyperammonemia (HP:0001987)3.60368806
21Large for gestational age (HP:0001520)3.60227564
22Conjugated hyperbilirubinemia (HP:0002908)3.44513904
23Hypoalphalipoproteinemia (HP:0003233)3.40675560
24Hypolipoproteinemia (HP:0010981)3.39987417
25Hyperglycinemia (HP:0002154)3.37102613
26Stomatitis (HP:0010280)3.33625573
27Hypoglycemic seizures (HP:0002173)3.28412481
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26375214
29Abnormality of the phalanges of the 2nd finger (HP:0009541)3.25321107
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24270518
31Complement deficiency (HP:0004431)3.22426979
32Abnormality of fatty-acid metabolism (HP:0004359)3.22350618
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.18148576
34Abnormality of the common coagulation pathway (HP:0010990)3.14904007
35Gout (HP:0001997)3.14552512
36Hyperinsulinemic hypoglycemia (HP:0000825)3.14027188
37Abnormality of dental color (HP:0011073)3.13078968
38Thyroiditis (HP:0100646)3.08764847
39Abnormality of methionine metabolism (HP:0010901)3.03087358
40Abnormality of the renal cortex (HP:0011035)3.01141516
41Abnormality of purine metabolism (HP:0004352)3.00487924
42Autoimmune hemolytic anemia (HP:0001890)2.90912989
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87845777
44Vascular calcification (HP:0004934)2.85075702
45Right ventricular cardiomyopathy (HP:0011663)2.83436000
46Abnormality of the intrinsic pathway (HP:0010989)2.78203319
47Pancreatic cysts (HP:0001737)2.77416793
48Steatorrhea (HP:0002570)2.77344330
49Joint hemorrhage (HP:0005261)2.77184793
50Breast carcinoma (HP:0003002)2.61673907
51Symptomatic seizures (HP:0011145)2.57870846
52Congenital stationary night blindness (HP:0007642)2.56953295
53Exercise-induced myalgia (HP:0003738)2.56123919
54Medial flaring of the eyebrow (HP:0010747)2.55237862
55Cardiovascular calcification (HP:0011915)2.53876062
56Concave nail (HP:0001598)2.53507609
57Abnormality of proline metabolism (HP:0010907)2.53040750
58Hydroxyprolinuria (HP:0003080)2.53040750
59Progressive macrocephaly (HP:0004481)2.52174304
60Myocardial infarction (HP:0001658)2.51817370
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50733529
62Dicarboxylic aciduria (HP:0003215)2.50733529
63Metabolic acidosis (HP:0001942)2.48137657
64Hypercholesterolemia (HP:0003124)2.47690482
65Disproportionate short-trunk short stature (HP:0003521)2.45452012
66Delayed CNS myelination (HP:0002188)2.45081714
67Hyperglycemia (HP:0003074)2.44128114
68Abnormality of midbrain morphology (HP:0002418)2.41032828
69Molar tooth sign on MRI (HP:0002419)2.41032828
70True hermaphroditism (HP:0010459)2.40385882
71Myoglobinuria (HP:0002913)2.39645970
72Hypomagnesemia (HP:0002917)2.38511133
73Abnormality of nucleobase metabolism (HP:0010932)2.37387270
74Hyperuricemia (HP:0002149)2.35975264
75Increased purine levels (HP:0004368)2.35975264
76Pancreatic fibrosis (HP:0100732)2.30725232
77Hypokalemic alkalosis (HP:0001949)2.28207285
78Hyporeflexia of lower limbs (HP:0002600)2.25070897
79Hyperbilirubinemia (HP:0002904)2.23971267
80Fair hair (HP:0002286)2.21555743
81Generalized aminoaciduria (HP:0002909)2.20351100
82Gaze-evoked nystagmus (HP:0000640)2.19119432
83Acute necrotizing encephalopathy (HP:0006965)2.18041289
84Pancreatitis (HP:0001733)2.17041763
85Albinism (HP:0001022)2.16667077
86Tongue fasciculations (HP:0001308)2.16174871
87Stomach cancer (HP:0012126)2.12821773
88Abnormality of complement system (HP:0005339)2.12566543
89Generalized hypopigmentation of hair (HP:0011358)2.12308220
90Neonatal respiratory distress (HP:0002643)2.10712071
91Lethargy (HP:0001254)2.09302717
92Hepatocellular carcinoma (HP:0001402)2.09000106
93Abnormality of T cell number (HP:0011839)2.07837596
94Methylmalonic acidemia (HP:0002912)2.06835716
95Attenuation of retinal blood vessels (HP:0007843)2.06423552
96Abnormal gallbladder morphology (HP:0012437)2.06265204
97Hepatic necrosis (HP:0002605)2.05690729
98Metabolic alkalosis (HP:0200114)2.05598866
99Late onset (HP:0003584)2.05396296
100Skin nodule (HP:0200036)2.04426115
101Pigmentary retinal degeneration (HP:0001146)2.04280824
102Severe combined immunodeficiency (HP:0004430)2.04048969
103Hypophosphatemic rickets (HP:0004912)2.03831681
104Short middle phalanx of the 5th finger (HP:0004220)2.01949725
105Abnormal rod and cone electroretinograms (HP:0008323)2.00557633
106Abnormality of the prostate (HP:0008775)2.00192655
107Hypoproteinemia (HP:0003075)2.00177764
108Posterior subcapsular cataract (HP:0007787)1.99965609
109Rickets (HP:0002748)1.99755301
110Insulin-resistant diabetes mellitus (HP:0000831)1.99237869
111Hamartoma of the eye (HP:0010568)1.97344548
112Abnormality of serum amino acid levels (HP:0003112)1.96074327
113Malnutrition (HP:0004395)1.95296067
114Nephronophthisis (HP:0000090)1.95194150
115Patchy hypopigmentation of hair (HP:0011365)1.94978867
116Hyperkalemia (HP:0002153)1.94501870
117Mitochondrial inheritance (HP:0001427)1.94321946
118Febrile seizures (HP:0002373)1.93930254
119Acute encephalopathy (HP:0006846)1.93716529
120Renal cortical cysts (HP:0000803)1.93515783
121Conjunctival hamartoma (HP:0100780)1.93169597
122Exercise-induced muscle cramps (HP:0003710)1.92234862
123Alveolar cell carcinoma (HP:0006519)1.91339407
124Pancreatic islet-cell hyperplasia (HP:0004510)1.90360069
125Increased CSF lactate (HP:0002490)1.90254681
126Hypoplastic iliac wings (HP:0002866)1.90006953
127Alopecia of scalp (HP:0002293)1.90006952
128Abnormality of the nasal septum (HP:0000419)1.89918501
129Abnormality of the renal medulla (HP:0100957)1.89796794
130Male pseudohermaphroditism (HP:0000037)1.87954670
131Follicular hyperkeratosis (HP:0007502)1.87938035
132Enlarged kidneys (HP:0000105)1.87744078
133Lip pit (HP:0100267)1.87554563
134Barrel-shaped chest (HP:0001552)1.86125434
135Abnormality of vitamin metabolism (HP:0100508)1.85345306
136Alkalosis (HP:0001948)1.84745497
137Axonal loss (HP:0003447)1.84413137
138Neurofibrillary tangles (HP:0002185)1.83949079
139Esophageal varix (HP:0002040)1.83236866
140Elevated erythrocyte sedimentation rate (HP:0003565)1.83086344
141Ileus (HP:0002595)1.82736919
142Chronic diarrhea (HP:0002028)1.82704310
143Cholelithiasis (HP:0001081)1.82274337
144IgG deficiency (HP:0004315)1.81901404
145Congenital, generalized hypertrichosis (HP:0004540)1.81271880
146Increased circulating renin level (HP:0000848)1.80846305
147Abnormal tarsal ossification (HP:0008369)1.80605300
148Protuberant abdomen (HP:0001538)1.80530353
149Irritability (HP:0000737)1.79440413
150Abnormality of eosinophils (HP:0001879)1.78817479
151Abnormality of vitamin B metabolism (HP:0004340)1.78746409
152Abnormality of the pancreatic islet cells (HP:0006476)1.78686545
153Abnormality of endocrine pancreas physiology (HP:0012093)1.78686545
154Hypoplasia of the odontoid process (HP:0003311)1.78529338
155Congenital primary aphakia (HP:0007707)1.78342248
156Type I diabetes mellitus (HP:0100651)1.78109564
157Abnormality of the pons (HP:0007361)1.77239755
158Abnormality of the 2nd finger (HP:0004100)1.76815721
159Vomiting (HP:0002013)1.76729090
160Abnormal mitochondria in muscle tissue (HP:0008316)1.74618999
161Proximal tubulopathy (HP:0000114)1.73945047
162Abnormal drinking behavior (HP:0030082)1.73882459
163Polydipsia (HP:0001959)1.73882459
164Glomerulosclerosis (HP:0000096)1.73799473
165Pulmonary infiltrates (HP:0002113)1.72871524
166Glycosuria (HP:0003076)1.71891169
167Abnormality of urine glucose concentration (HP:0011016)1.71891169
168Chronic hepatic failure (HP:0100626)1.71840331
169Sensorimotor neuropathy (HP:0007141)1.71631959
170Curly hair (HP:0002212)1.71256518
171Polyuria (HP:0000103)1.71077735
172Acanthosis nigricans (HP:0000956)1.70417591
173Gait imbalance (HP:0002141)1.69929584
174Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69091477
175Respiratory distress (HP:0002098)1.68918582
176Hyperventilation (HP:0002883)1.68472061
177Muscle fiber splitting (HP:0003555)1.68346858
178Tubular atrophy (HP:0000092)1.68248393
179Intestinal atresia (HP:0011100)1.68089654
180Hypoplasia of the fovea (HP:0007750)1.67850646
181Aplasia/Hypoplasia of the fovea (HP:0008060)1.67850646
182Abolished electroretinogram (ERG) (HP:0000550)1.67581679
183Hemorrhage of the eye (HP:0011885)1.67554101
184Amyloidosis (HP:0011034)1.67054452
185Muscle fiber inclusion bodies (HP:0100299)1.67013408
186Confusion (HP:0001289)1.66549360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.83260215
2BRSK23.59290075
3MAPK153.45509589
4ERBB33.19773098
5SIK13.12505513
6INSRR3.11629747
7TRIM282.85899185
8SIK32.57539711
9EIF2AK32.54365284
10EPHB12.52736401
11WEE12.51975021
12ERN12.45712430
13LATS12.24979401
14WNK42.21625019
15FRK2.20378053
16CASK2.02487584
17STK392.02298507
18MST1R1.88338716
19MAP2K21.87257033
20MAP3K121.86465055
21PIK3CG1.72702901
22FGFR41.70371724
23OBSCN1.69019907
24FGFR21.67692626
25MAP3K31.61575488
26BMPR21.58967203
27MST41.58019250
28MET1.53176261
29ERBB41.46198619
30TSSK61.45138877
31OXSR11.41604786
32TAOK31.33942627
33TEC1.30281216
34PHKG21.25274192
35PHKG11.25274192
36IRAK31.25064280
37PRKCI1.23542196
38IKBKB1.23264001
39MAP3K21.22313242
40PIK3CA1.19187589
41PRKAA21.18444019
42PTK61.17367479
43TRIB31.17085530
44TXK1.16660778
45ADRBK21.15614415
46BRSK11.15408292
47MKNK21.14511761
48SGK2231.09414152
49SGK4941.09414152
50MAP4K21.09087109
51PKN11.06988622
52STK101.04725559
53EPHA31.04324206
54STK38L1.03895205
55IRAK11.01530614
56GRK11.01491716
57FER1.01038463
58EPHB21.00445882
59MAP3K70.99312924
60RIPK10.98255050
61PAK30.98254370
62GSK3A0.97969631
63PINK10.91741153
64IRAK20.91290145
65TIE10.91042044
66CAMK1G0.89656552
67PDK20.88212190
68CAMK1D0.86690135
69CHUK0.83940675
70DYRK1B0.82795808
71PTK20.81521655
72AKT30.79499691
73CAMK2G0.77547280
74NLK0.77250632
75WNK30.77157137
76DMPK0.76646259
77PRKD10.76501134
78BCR0.76324675
79EIF2AK10.76085362
80TNIK0.75287194
81WNK10.74184467
82SGK30.74155339
83ACVR1B0.74152917
84SGK20.73328861
85PLK20.73130218
86GRK60.71551469
87MAP2K10.71140730
88PRKAA10.69301507
89MUSK0.69105260
90MAPK120.66631648
91MAPK70.66407392
92HIPK20.64525841
93NEK90.64475354
94MARK30.62420405
95MAP3K10.61287694
96BRD40.60812140
97STK30.60452948
98TTN0.59588753
99ZAK0.59026200
100TLK10.56029915
101PNCK0.54956300
102TRPM70.54940535
103CAMK2D0.54803484
104NUAK10.54464250
105JAK10.53848336
106BMPR1B0.53723885
107PRKG20.53687889
108MAPKAPK50.53683227
109NEK60.53553112
110EPHA20.53542673
111CDK80.53447993
112MAPK110.52903572
113DDR20.52050043
114CSK0.51528023
115PBK0.51424591
116NME10.51122045
117LMTK20.51081466
118PRKCE0.49637137
119PDPK10.48742690
120MAP3K140.48475462
121JAK20.48029673
122TYK20.47672454
123FGFR30.45607633
124PRKACG0.43170407
125PRKCQ0.42855083
126ABL10.42507439
127MAPKAPK30.42506628
128MAP2K40.42138859
129CAMK2B0.41362523
130TGFBR20.41233368
131ITK0.39789623
132CAMKK20.39749456
133IKBKE0.39747996
134MAP2K60.39676684
135CSNK1G10.39573637
136ERBB20.37477423
137DYRK1A0.36777638
138NTRK10.36574446
139IGF1R0.35750871
140MYLK0.35319224
141EIF2AK20.34407295
142ADRBK10.34343821
143STK240.33463241
144ROCK10.33088840
145PTK2B0.30203574
146DYRK30.29671147
147FGFR10.28527494
148EGFR0.27993604
149MAPK130.26839957
150RPS6KB10.26382452
151PRKCG0.24330885
152CSNK1G30.24197770
153PLK30.23310310
154TAF10.23220595
155CSNK1A10.22740109
156TNK20.21235755

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.22666220
2Nitrogen metabolism_Homo sapiens_hsa009103.09043093
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.73773936
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71617876
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59381870
6Fatty acid degradation_Homo sapiens_hsa000712.49264987
7Proteasome_Homo sapiens_hsa030502.38203276
8Tryptophan metabolism_Homo sapiens_hsa003802.35876881
9Sulfur metabolism_Homo sapiens_hsa009202.32048385
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31133467
11Arginine biosynthesis_Homo sapiens_hsa002202.30440349
12Propanoate metabolism_Homo sapiens_hsa006402.21942734
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16437557
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08871394
15Butanoate metabolism_Homo sapiens_hsa006502.06356628
16Histidine metabolism_Homo sapiens_hsa003402.01694074
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01605729
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00774715
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96805973
20Fatty acid metabolism_Homo sapiens_hsa012121.91717546
21PPAR signaling pathway_Homo sapiens_hsa033201.87513108
22Peroxisome_Homo sapiens_hsa041461.87500847
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.87136730
24Fat digestion and absorption_Homo sapiens_hsa049751.82122248
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77852921
26Complement and coagulation cascades_Homo sapiens_hsa046101.76416494
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75769367
28Chemical carcinogenesis_Homo sapiens_hsa052041.75538017
29Basal transcription factors_Homo sapiens_hsa030221.75242020
30Phototransduction_Homo sapiens_hsa047441.74925302
31Fatty acid elongation_Homo sapiens_hsa000621.74377055
32Type I diabetes mellitus_Homo sapiens_hsa049401.74101417
33Caffeine metabolism_Homo sapiens_hsa002321.73592775
34Regulation of autophagy_Homo sapiens_hsa041401.70695804
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.67676022
36Collecting duct acid secretion_Homo sapiens_hsa049661.59254646
37beta-Alanine metabolism_Homo sapiens_hsa004101.58328675
38Steroid biosynthesis_Homo sapiens_hsa001001.54740032
39Starch and sucrose metabolism_Homo sapiens_hsa005001.54361055
40Oxidative phosphorylation_Homo sapiens_hsa001901.52137840
41Bile secretion_Homo sapiens_hsa049761.47489161
42Retinol metabolism_Homo sapiens_hsa008301.42129871
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35082308
44Primary immunodeficiency_Homo sapiens_hsa053401.31963682
45Folate biosynthesis_Homo sapiens_hsa007901.30906659
46Phenylalanine metabolism_Homo sapiens_hsa003601.29888404
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29448900
48Pyruvate metabolism_Homo sapiens_hsa006201.29025342
49Vitamin digestion and absorption_Homo sapiens_hsa049771.28903290
50T cell receptor signaling pathway_Homo sapiens_hsa046601.28149149
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26284752
52Tyrosine metabolism_Homo sapiens_hsa003501.25951142
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24757709
54* RNA degradation_Homo sapiens_hsa030181.21711446
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21601811
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20052113
57RNA polymerase_Homo sapiens_hsa030201.19541445
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18021393
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16346615
60ABC transporters_Homo sapiens_hsa020101.14148114
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10296538
62Arginine and proline metabolism_Homo sapiens_hsa003301.09738349
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06994886
64Selenocompound metabolism_Homo sapiens_hsa004501.05886519
65Legionellosis_Homo sapiens_hsa051341.01973848
66Glycerolipid metabolism_Homo sapiens_hsa005611.01275823
67Drug metabolism - other enzymes_Homo sapiens_hsa009831.00659225
68Autoimmune thyroid disease_Homo sapiens_hsa053200.98597124
69Fatty acid biosynthesis_Homo sapiens_hsa000610.95833246
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88064717
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86057740
72Allograft rejection_Homo sapiens_hsa053300.85634387
73Staphylococcus aureus infection_Homo sapiens_hsa051500.84772221
74Carbon metabolism_Homo sapiens_hsa012000.81165972
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78291029
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.76952849
77Graft-versus-host disease_Homo sapiens_hsa053320.75368697
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73789659
79Glutathione metabolism_Homo sapiens_hsa004800.70915277
80Protein digestion and absorption_Homo sapiens_hsa049740.68947410
81Linoleic acid metabolism_Homo sapiens_hsa005910.68930663
82Measles_Homo sapiens_hsa051620.68760726
83Parkinsons disease_Homo sapiens_hsa050120.68413106
84Lysine degradation_Homo sapiens_hsa003100.67984079
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67920424
86Fanconi anemia pathway_Homo sapiens_hsa034600.66672579
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.64762063
88Rheumatoid arthritis_Homo sapiens_hsa053230.63929759
89Biosynthesis of amino acids_Homo sapiens_hsa012300.62720556
90Asthma_Homo sapiens_hsa053100.62087545
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58039450
92Amphetamine addiction_Homo sapiens_hsa050310.57508214
93Pancreatic secretion_Homo sapiens_hsa049720.56891566
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56371626
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55631066
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.55577405
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55299255
98Insulin resistance_Homo sapiens_hsa049310.54262441
99Sulfur relay system_Homo sapiens_hsa041220.52761092
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52147458
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51950848
102Dorso-ventral axis formation_Homo sapiens_hsa043200.50340642
103Renin secretion_Homo sapiens_hsa049240.49938432
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49387085
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48536076
106Mineral absorption_Homo sapiens_hsa049780.48058158
107Homologous recombination_Homo sapiens_hsa034400.43789211
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43663577
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.43344940
110Circadian rhythm_Homo sapiens_hsa047100.41792583
111Metabolic pathways_Homo sapiens_hsa011000.39110230
112Galactose metabolism_Homo sapiens_hsa000520.37747744
113Alzheimers disease_Homo sapiens_hsa050100.35117420
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.34494797
115Vibrio cholerae infection_Homo sapiens_hsa051100.34123954
116Hematopoietic cell lineage_Homo sapiens_hsa046400.33580554
117Vitamin B6 metabolism_Homo sapiens_hsa007500.32146957
118Ether lipid metabolism_Homo sapiens_hsa005650.31323826
119Protein export_Homo sapiens_hsa030600.31089195
120Glucagon signaling pathway_Homo sapiens_hsa049220.30958937
121FoxO signaling pathway_Homo sapiens_hsa040680.30723144
122cAMP signaling pathway_Homo sapiens_hsa040240.29975442
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29243465
124Purine metabolism_Homo sapiens_hsa002300.26983860
125AMPK signaling pathway_Homo sapiens_hsa041520.26775472
126Ovarian steroidogenesis_Homo sapiens_hsa049130.25969901
127Sphingolipid metabolism_Homo sapiens_hsa006000.21200775
128Renin-angiotensin system_Homo sapiens_hsa046140.20585486
129Prion diseases_Homo sapiens_hsa050200.20381995
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19546087
131Arachidonic acid metabolism_Homo sapiens_hsa005900.19508844
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16907242
133Fructose and mannose metabolism_Homo sapiens_hsa000510.14776313
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14324228
135Insulin secretion_Homo sapiens_hsa049110.13626930
136Thyroid hormone synthesis_Homo sapiens_hsa049180.11797001
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11794096
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11320732
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10136588
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08731253
141Tight junction_Homo sapiens_hsa045300.06997286
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06799717
143Pentose phosphate pathway_Homo sapiens_hsa000300.05698471

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