TOB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)5.34914946
2endothelial cell chemotaxis (GO:0035767)5.05328899
3regulation of gamma-delta T cell activation (GO:0046643)4.85421540
4tolerance induction (GO:0002507)4.27018012
5positive thymic T cell selection (GO:0045059)4.25119605
6positive regulation of gamma-delta T cell activation (GO:0046645)4.23290714
7regulation of interleukin-12 biosynthetic process (GO:0045075)4.11809277
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.09690947
9regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.09058804
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.99769295
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79964652
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79964652
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.73455790
14antigen processing and presentation of endogenous antigen (GO:0019883)3.73455163
15thymic T cell selection (GO:0045061)3.67124334
16lymph vessel development (GO:0001945)3.66916357
17NIK/NF-kappaB signaling (GO:0038061)3.65490488
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.65200414
19adherens junction assembly (GO:0034333)3.64736516
20regulation of chromatin binding (GO:0035561)3.55227232
21response to muramyl dipeptide (GO:0032495)3.51205049
22interferon-gamma production (GO:0032609)3.48349056
23JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.44574314
24negative T cell selection (GO:0043383)3.43974168
25negative thymic T cell selection (GO:0045060)3.42131102
26heart trabecula formation (GO:0060347)3.41723131
27positive T cell selection (GO:0043368)3.40213764
28sodium ion export (GO:0071436)3.34522044
29response to interleukin-15 (GO:0070672)3.34446639
30heart valve formation (GO:0003188)3.32293808
31T cell selection (GO:0045058)3.28351986
32growth hormone receptor signaling pathway (GO:0060396)3.15189584
33cellular protein complex localization (GO:0034629)3.14427823
34regulation of cholesterol homeostasis (GO:2000188)3.13871830
35positive regulation of histone deacetylation (GO:0031065)3.11475800
36ear development (GO:0043583)3.10310520
37regulation of apoptotic process involved in morphogenesis (GO:1902337)3.09458436
38ventricular septum morphogenesis (GO:0060412)3.09339353
39notochord development (GO:0030903)3.03912636
40positive regulation of fatty acid beta-oxidation (GO:0032000)2.95641589
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.95048565
42muscle filament sliding (GO:0030049)2.94858043
43actin-myosin filament sliding (GO:0033275)2.94858043
44cardiac myofibril assembly (GO:0055003)2.93735006
45response to laminar fluid shear stress (GO:0034616)2.93712194
46cell migration involved in sprouting angiogenesis (GO:0002042)2.93048656
47focal adhesion assembly (GO:0048041)2.89955966
48cell-substrate adherens junction assembly (GO:0007045)2.89955966
49valine metabolic process (GO:0006573)2.88413435
50prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87905135
51atrioventricular valve morphogenesis (GO:0003181)2.87373439
52positive regulation of interleukin-2 production (GO:0032743)2.86953938
53Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85453669
54regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.84022637
55positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.84022637
56paraxial mesoderm development (GO:0048339)2.83754481
57regulation of interleukin-2 biosynthetic process (GO:0045076)2.80925851
58mammary gland epithelial cell differentiation (GO:0060644)2.80575812
59endocardial cushion morphogenesis (GO:0003203)2.80555900
60non-canonical Wnt signaling pathway (GO:0035567)2.78371251
61T cell migration (GO:0072678)2.76771288
62T-helper cell differentiation (GO:0042093)2.76425535
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.76425535
64myofibril assembly (GO:0030239)2.74471945
65regulation of T cell tolerance induction (GO:0002664)2.74259187
66regulation of sequestering of triglyceride (GO:0010889)2.74171262
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73291308
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73138094
69negative regulation of cell killing (GO:0031342)2.73138094
70negative regulation of erythrocyte differentiation (GO:0045647)2.69956904
71regulation of establishment of planar polarity (GO:0090175)2.68799107
72cellular response to growth hormone stimulus (GO:0071378)2.68364552
73regulation of p38MAPK cascade (GO:1900744)2.68244171
74aorta morphogenesis (GO:0035909)2.67824388
75positive regulation of mRNA catabolic process (GO:0061014)2.66708630
76negative regulation of myoblast differentiation (GO:0045662)2.65533325
77positive regulation of lipid storage (GO:0010884)2.63988104
78trabecula formation (GO:0060343)2.62992581
79positive regulation of natural killer cell differentiation (GO:0032825)2.62654319
80myeloid dendritic cell differentiation (GO:0043011)2.61928603
81positive regulation of p38MAPK cascade (GO:1900745)2.61346512
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61214984
83skeletal muscle contraction (GO:0003009)2.60958945
84negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59915503
85camera-type eye morphogenesis (GO:0048593)2.59722348
86positive regulation of fatty acid oxidation (GO:0046321)2.58862009
87sarcoplasmic reticulum calcium ion transport (GO:0070296)2.58699775
88leukocyte aggregation (GO:0070486)2.58463677
89lipid storage (GO:0019915)2.58332153
90positive regulation of B cell differentiation (GO:0045579)2.57641324
91regulation of cholesterol storage (GO:0010885)2.56884008
92cell-cell signaling involved in cell fate commitment (GO:0045168)2.56622719
93regulation of B cell receptor signaling pathway (GO:0050855)2.56578098
94cellular response to interleukin-15 (GO:0071350)2.56557933
95kidney mesenchyme development (GO:0072074)2.55763140
96mesenchyme morphogenesis (GO:0072132)2.55181287
97regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.55015509
98heart valve morphogenesis (GO:0003179)2.53982943
99convergent extension (GO:0060026)2.53416835
100carnitine shuttle (GO:0006853)2.52487674
101negative regulation of lipid storage (GO:0010888)2.52198693
102branching involved in salivary gland morphogenesis (GO:0060445)2.51576635
103regulation of NFAT protein import into nucleus (GO:0051532)2.51010804
104fatty acid transmembrane transport (GO:1902001)2.50493811
105myeloid dendritic cell activation (GO:0001773)2.50437350
106cardiac muscle adaptation (GO:0014887)2.49685251
107cardiac muscle hypertrophy in response to stress (GO:0014898)2.49685251
108muscle hypertrophy in response to stress (GO:0003299)2.49685251
109regulation of response to interferon-gamma (GO:0060330)2.49594791
110regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49245662
111cellular extravasation (GO:0045123)2.49162316
112creatine metabolic process (GO:0006600)2.48697148
113activation of MAPKKK activity (GO:0000185)2.48440771
114protein complex localization (GO:0031503)2.48298578
115negative regulation of granulocyte differentiation (GO:0030853)2.47964277
116cerebellar granule cell differentiation (GO:0021707)2.47522621
117negative regulation of catenin import into nucleus (GO:0035414)2.47498755
118cochlea morphogenesis (GO:0090103)2.47033767
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.46713199
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.45408056
121developmental induction (GO:0031128)2.45375904
122actin-mediated cell contraction (GO:0070252)2.44689847
123mammary gland development (GO:0030879)2.44405087
124cell-cell junction maintenance (GO:0045217)2.44097625
125negative regulation of fatty acid transport (GO:2000192)2.44072893
126regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.42778381
127Notch signaling involved in heart development (GO:0061314)2.42399862
128negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41378392
129regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.41123622
130positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.41123622
131regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40615262
132pattern specification involved in kidney development (GO:0061004)2.40574002
133response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40210078
134regulation of B cell differentiation (GO:0045577)2.39244793
135tyrosine phosphorylation of STAT protein (GO:0007260)2.39095802
136cardiac muscle cell proliferation (GO:0060038)2.38687198
137regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.38517773
138regulation of heart morphogenesis (GO:2000826)2.37814401
139ovulation from ovarian follicle (GO:0001542)2.37755116
140G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.37596483
141myotube differentiation (GO:0014902)2.37285455
142regulation of mRNA catabolic process (GO:0061013)2.37207522
143T cell receptor signaling pathway (GO:0050852)2.37181158
144cardiac muscle hypertrophy (GO:0003300)2.37036774
145embryonic process involved in female pregnancy (GO:0060136)2.36771008
146T cell differentiation involved in immune response (GO:0002292)2.36672699
147alpha-beta T cell differentiation involved in immune response (GO:0002293)2.36672699
148alpha-beta T cell activation involved in immune response (GO:0002287)2.36672699
149blood vessel endothelial cell migration (GO:0043534)2.35970957
150metanephric mesenchyme development (GO:0072075)2.35248297
151negative regulation of inclusion body assembly (GO:0090084)2.35160686
152regulation of fatty acid beta-oxidation (GO:0031998)2.33767020
153positive regulation of cholesterol efflux (GO:0010875)2.33349379
154nephron tubule formation (GO:0072079)2.32877292
155negative regulation of bone resorption (GO:0045779)2.32601777
156respiratory system process (GO:0003016)2.32591135
157cardiac septum morphogenesis (GO:0060411)2.31713270
158negative regulation of innate immune response (GO:0045824)2.31513279
159peripheral nervous system axon ensheathment (GO:0032292)2.31404218
160myelination in peripheral nervous system (GO:0022011)2.31404218
161cell-substrate junction assembly (GO:0007044)2.31322015
162otic vesicle formation (GO:0030916)2.30996216
163ventricular trabecula myocardium morphogenesis (GO:0003222)2.30891368
164cell communication by electrical coupling (GO:0010644)2.30627092
165cell proliferation involved in metanephros development (GO:0072203)2.30344005
166regulation of fatty acid oxidation (GO:0046320)2.30326625
167striated muscle hypertrophy (GO:0014897)2.29866065
168positive regulation of tolerance induction (GO:0002645)2.28856884
169semaphorin-plexin signaling pathway (GO:0071526)2.27335417
170cellular potassium ion homeostasis (GO:0030007)2.26472540
171embryonic camera-type eye morphogenesis (GO:0048596)2.25762285
172epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.25646660
173regulation of triglyceride catabolic process (GO:0010896)2.25354469
174T cell costimulation (GO:0031295)2.25240380
175negative regulation of cell fate specification (GO:0009996)2.24929914
176axon ensheathment in central nervous system (GO:0032291)2.24864222
177central nervous system myelination (GO:0022010)2.24864222
178osteoblast development (GO:0002076)2.24737101
179regulation of cardioblast differentiation (GO:0051890)2.24734829
180positive regulation of humoral immune response (GO:0002922)2.24696169
181basement membrane organization (GO:0071711)2.24656339
182apoptotic process involved in morphogenesis (GO:0060561)2.24609407
183cGMP-mediated signaling (GO:0019934)2.24366444
184regulation of hypersensitivity (GO:0002883)2.24265519
185JAK-STAT cascade (GO:0007259)2.24230216
186negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23967494
187natural killer cell differentiation (GO:0001779)2.23625329
188positive regulation of protein deacetylation (GO:0090312)2.23267299
189positive regulation of sterol transport (GO:0032373)2.21720603
190positive regulation of cholesterol transport (GO:0032376)2.21720603
191cytoplasmic mRNA processing body assembly (GO:0033962)2.20290828
192lymphocyte costimulation (GO:0031294)2.17620884
193regulation of tolerance induction (GO:0002643)2.17279306
194positive regulation of lipid catabolic process (GO:0050996)2.16708706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.36318096
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31615340
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46240031
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.18613022
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.85230069
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83602463
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.83399389
8RUNX_20019798_ChIP-Seq_JUKART_Human2.69787110
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64247434
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.60779790
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56243222
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.50970262
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.49321586
14* MYC_22102868_ChIP-Seq_BL_Human2.48832140
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41500163
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.37175509
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33667062
18* LXR_22158963_ChIP-Seq_LIVER_Mouse2.29821402
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23998567
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22199302
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21796323
22* TCF7_22412390_ChIP-Seq_EML_Mouse2.19994113
23* CLOCK_20551151_ChIP-Seq_293T_Human2.17574568
24MAF_26560356_Chip-Seq_TH1_Human2.14427786
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13062923
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09985777
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.09872749
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06761725
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06258796
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06146754
31SCL_19346495_ChIP-Seq_HPC-7_Human2.04683337
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01887047
33MYB_26560356_Chip-Seq_TH2_Human1.98022835
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97629786
35VDR_21846776_ChIP-Seq_THP-1_Human1.96728517
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.95521314
37KDM2B_26808549_Chip-Seq_DND41_Human1.91711152
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91327888
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91188098
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88259701
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88259701
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88259701
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.87300200
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.82976748
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81099648
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80965261
47MYB_26560356_Chip-Seq_TH1_Human1.80962307
48* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80049522
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79645385
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77514902
51UTX_26944678_Chip-Seq_JUKART_Human1.77416851
52* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76662874
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75367662
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75367662
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74255949
56* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72886664
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72159037
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71477849
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.70884166
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68280591
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66994256
62* VDR_24763502_ChIP-Seq_THP-1_Human1.63585315
63* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61646135
64* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60069564
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.58524812
66* CREB1_26743006_Chip-Seq_LNCaP_Human1.57537585
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57178201
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56177721
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.54697461
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.54267764
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52256531
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.51926478
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.50315585
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.49460227
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49026297
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48975971
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43974094
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43254780
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.42945672
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42391678
81CTCF_27219007_Chip-Seq_Bcells_Human1.40970129
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.38842055
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.38819161
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.38128043
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37234949
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36761095
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.35633916
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34392435
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33842730
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31241088
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30833201
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30245525
93MAF_26560356_Chip-Seq_TH2_Human1.30012056
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29669443
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28798297
96GATA1_19941826_ChIP-Seq_K562_Human1.27710422
97VDR_24787735_ChIP-Seq_THP-1_Human1.25531171
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25265551
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25137550
100* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25121577
101CDX2_20551321_ChIP-Seq_CACO-2_Human1.25001267
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.24911332
103GATA3_27048872_Chip-Seq_THYMUS_Human1.24750299
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.24607070
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22919608
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21870030
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21285075
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.20881263
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19573349
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19433769
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.19418376
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19313781
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17418699
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17331148
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17040819
116PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16817432
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15791038
118* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15661190
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14814284
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.14409415
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14090412
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13752566
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12947218
124TBX20_22328084_ChIP-Seq_HEART_Mouse1.12000253
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.12000253
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11782967
127GATA2_19941826_ChIP-Seq_K562_Human1.11778358
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11615783
129* SMC4_20622854_ChIP-Seq_HELA_Human1.11058566
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10852194
131SPI1_23127762_ChIP-Seq_K562_Human1.10683678
132PU_27001747_Chip-Seq_BMDM_Mouse1.10671956
133* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10623340
134SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09505003
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09016643
136RUNX1_27514584_Chip-Seq_MCF-7_Human1.08003172
137SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07766679
138RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07415702
139DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07399684
140* RACK7_27058665_Chip-Seq_MCF-7_Human1.07166148
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05810166
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05397707
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.04097265
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04063306
145CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04030400
146UBF1/2_26484160_Chip-Seq_HMECs_Human1.03341938
147* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03287066
148GATA1_19941827_ChIP-Seq_MEL_Mouse1.00911792
149LXR_22292898_ChIP-Seq_THP-1_Human0.99506921
150* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98394340
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97456135
152KDM2B_26808549_Chip-Seq_K562_Human0.97392384
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96229700
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95879888
155NCOR1_26117541_ChIP-Seq_K562_Human0.95226424
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94968932
157* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94030129
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89887637
159EGR1_19032775_ChIP-ChIP_M12_Human0.89211065
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86470955
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84752756
162ZNF263_19887448_ChIP-Seq_K562_Human0.84166757
163* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82724987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.15046147
2MP0004510_myositis2.90532884
3MP0002249_abnormal_larynx_morphology2.76878697
4MP0010030_abnormal_orbit_morphology2.74424121
5MP0000685_abnormal_immune_system2.71291766
6MP0000566_synostosis2.69920554
7MP0003763_abnormal_thymus_physiology2.60370574
8MP0005623_abnormal_meninges_morphology2.56322289
9MP0001790_abnormal_immune_system2.52838345
10MP0005387_immune_system_phenotype2.52838345
11MP0003011_delayed_dark_adaptation2.47407511
12MP0003436_decreased_susceptibility_to2.47379718
13MP0003724_increased_susceptibility_to2.38777627
14MP0009379_abnormal_foot_pigmentation2.37092420
15MP0003303_peritoneal_inflammation2.31980015
16MP0001346_abnormal_lacrimal_gland2.29251548
17MP0001835_abnormal_antigen_presentation2.20138930
18MP0001800_abnormal_humoral_immune2.19533236
19MP0002138_abnormal_hepatobiliary_system2.19448632
20MP0003300_gastrointestinal_ulcer2.13967208
21MP0005000_abnormal_immune_tolerance2.10664038
22MP0005670_abnormal_white_adipose2.04779971
23MP0001853_heart_inflammation2.02306172
24MP0004272_abnormal_basement_membrane2.00400969
25MP0005503_abnormal_tendon_morphology1.93551756
26MP0009840_abnormal_foam_cell1.93217386
27MP0002405_respiratory_system_inflammati1.92210661
28MP0004947_skin_inflammation1.90312678
29MP0002723_abnormal_immune_serum1.89188318
30MP0005360_urolithiasis1.88694685
31MP0009780_abnormal_chondrocyte_physiolo1.88576870
32MP0002166_altered_tumor_susceptibility1.84619529
33MP0000537_abnormal_urethra_morphology1.84474196
34* MP0002452_abnormal_antigen_presenting1.81463378
35MP0000762_abnormal_tongue_morphology1.78654614
36MP0000534_abnormal_ureter_morphology1.78077284
37MP0004087_abnormal_muscle_fiber1.77115280
38MP0004858_abnormal_nervous_system1.76187139
39MP0005671_abnormal_response_to1.75570641
40MP0002108_abnormal_muscle_morphology1.68354336
41MP0008961_abnormal_basal_metabolism1.66196722
42MP0010155_abnormal_intestine_physiology1.65472914
43* MP0002420_abnormal_adaptive_immunity1.64269297
44MP0001873_stomach_inflammation1.63608693
45MP0001851_eye_inflammation1.62851678
46* MP0001819_abnormal_immune_cell1.62423901
47MP0000579_abnormal_nail_morphology1.61622171
48* MP0002419_abnormal_innate_immunity1.60368509
49MP0000749_muscle_degeneration1.59796477
50MP0003191_abnormal_cellular_cholesterol1.59566512
51MP0005508_abnormal_skeleton_morphology1.58512551
52MP0009278_abnormal_bone_marrow1.57470946
53MP0005409_darkened_coat_color1.57201679
54MP0005025_abnormal_response_to1.55936868
55MP0002254_reproductive_system_inflammat1.54791319
56MP0005666_abnormal_adipose_tissue1.53743952
57MP0002796_impaired_skin_barrier1.53273268
58MP0000759_abnormal_skeletal_muscle1.52652346
59MP0004185_abnormal_adipocyte_glucose1.50042015
60MP0009053_abnormal_anal_canal1.49930210
61MP0002148_abnormal_hypersensitivity_rea1.49484896
62MP0000733_abnormal_muscle_development1.48231833
63MP0003942_abnormal_urinary_system1.48025577
64MP0003091_abnormal_cell_migration1.47496063
65MP0004233_abnormal_muscle_weight1.47300806
66MP0003279_aneurysm1.47194084
67MP0000049_abnormal_middle_ear1.47046560
68MP0003941_abnormal_skin_development1.46328744
69MP0002139_abnormal_hepatobiliary_system1.45831827
70MP0009785_altered_susceptibility_to1.45735142
71MP0006082_CNS_inflammation1.44386894
72MP0001533_abnormal_skeleton_physiology1.43967734
73MP0000609_abnormal_liver_physiology1.41932547
74MP0001502_abnormal_circadian_rhythm1.41679583
75MP0005076_abnormal_cell_differentiation1.41537976
76MP0000747_muscle_weakness1.41260511
77MP0006138_congestive_heart_failure1.40650220
78MP0009250_abnormal_appendicular_skeleto1.39659410
79MP0002933_joint_inflammation1.39206618
80MP0003705_abnormal_hypodermis_morpholog1.38682544
81MP0000750_abnormal_muscle_regeneration1.38342490
82MP0005365_abnormal_bile_salt1.38294238
83MP0003950_abnormal_plasma_membrane1.37478593
84MP0009384_cardiac_valve_regurgitation1.37249601
85MP0002398_abnormal_bone_marrow1.37034567
86* MP0000716_abnormal_immune_system1.36378253
87MP0000465_gastrointestinal_hemorrhage1.35909646
88MP0001845_abnormal_inflammatory_respons1.35197960
89MP0001849_ear_inflammation1.33890020
90MP0002006_tumorigenesis1.32626912
91MP0004145_abnormal_muscle_electrophysio1.28627411
92MP0003453_abnormal_keratinocyte_physiol1.28240667
93MP0008438_abnormal_cutaneous_collagen1.28035711
94MP0005464_abnormal_platelet_physiology1.27760200
95MP0005257_abnormal_intraocular_pressure1.25461627
96MP0001299_abnormal_eye_distance/1.24950693
97MP0000467_abnormal_esophagus_morphology1.23217170
98MP0000003_abnormal_adipose_tissue1.22987633
99MP0004130_abnormal_muscle_cell1.21457374
100MP0003252_abnormal_bile_duct1.21456207
101MP0003566_abnormal_cell_adhesion1.21083969
102MP0005423_abnormal_somatic_nervous1.20851518
103MP0009333_abnormal_splenocyte_physiolog1.20347786
104MP0000689_abnormal_spleen_morphology1.20230471
105MP0003828_pulmonary_edema1.19939595
106MP0002697_abnormal_eye_size1.19208703
107MP0002971_abnormal_brown_adipose1.19169335
108MP0005551_abnormal_eye_electrophysiolog1.19011439
109MP0003938_abnormal_ear_development1.18988409
110MP0009672_abnormal_birth_weight1.17856360
111MP0002722_abnormal_immune_system1.17808238
112MP0005275_abnormal_skin_tensile1.15983142
113MP0005369_muscle_phenotype1.15496931
114MP0003866_abnormal_defecation1.15422361
115MP0002116_abnormal_craniofacial_bone1.14594180
116MP0004036_abnormal_muscle_relaxation1.14141650
117MP0004808_abnormal_hematopoietic_stem1.13917982
118MP0000703_abnormal_thymus_morphology1.13598670
119MP0010329_abnormal_lipoprotein_level1.12461887
120MP0010368_abnormal_lymphatic_system1.11726595
121* MP0002998_abnormal_bone_remodeling1.11361657
122MP0005375_adipose_tissue_phenotype1.11253091
123MP0003136_yellow_coat_color1.10118132
124MP0002106_abnormal_muscle_physiology1.05686519
125* MP0002429_abnormal_blood_cell1.04366465
126MP0003045_fibrosis1.04355442
127MP0000516_abnormal_urinary_system1.03734331
128MP0005367_renal/urinary_system_phenotyp1.03734331
129MP0008469_abnormal_protein_level1.01942025
130MP0002896_abnormal_bone_mineralization1.01917117
131MP0008875_abnormal_xenobiotic_pharmacok1.01705096
132MP0004264_abnormal_extraembryonic_tissu1.01231507
133MP0005620_abnormal_muscle_contractility1.01218492
134MP0003755_abnormal_palate_morphology1.01067070
135MP0001545_abnormal_hematopoietic_system1.00819432
136MP0005397_hematopoietic_system_phenotyp1.00819432
137MP0005310_abnormal_salivary_gland1.00088917
138MP0002009_preneoplasia1.00050684
139MP0005085_abnormal_gallbladder_physiolo0.99618049
140MP0010352_gastrointestinal_tract_polyps0.99096434
141MP0005451_abnormal_body_composition0.97937806
142MP0009115_abnormal_fat_cell0.96225248
143MP0002396_abnormal_hematopoietic_system0.96072248
144MP0002877_abnormal_melanocyte_morpholog0.95594994
145MP0000767_abnormal_smooth_muscle0.94867447
146MP0002098_abnormal_vibrissa_morphology0.94282842
147MP0002060_abnormal_skin_morphology0.93382374
148MP0002118_abnormal_lipid_homeostasis0.92583168
149MP0000428_abnormal_craniofacial_morphol0.89587962
150MP0001340_abnormal_eyelid_morphology0.88657853
151MP0002282_abnormal_trachea_morphology0.88466824
152MP0000432_abnormal_head_morphology0.88169284
153MP0000249_abnormal_blood_vessel0.88063195
154MP0001243_abnormal_dermal_layer0.87956260
155MP0000343_altered_response_to0.87412258
156MP0003448_altered_tumor_morphology0.86749517
157MP0002269_muscular_atrophy0.86067701
158MP0003634_abnormal_glial_cell0.85396401
159MP0003879_abnormal_hair_cell0.85082424
160MP0003115_abnormal_respiratory_system0.85063844
161MP0005334_abnormal_fat_pad0.84385731
162MP0003075_altered_response_to0.83351517
163MP0000462_abnormal_digestive_system0.83200386
164MP0001958_emphysema0.83157945
165MP0001216_abnormal_epidermal_layer0.82450958
166MP0009764_decreased_sensitivity_to0.82375099
167MP0008569_lethality_at_weaning0.81368099
168MP0005330_cardiomyopathy0.81257452
169MP0002972_abnormal_cardiac_muscle0.80966155
170MP0000678_abnormal_parathyroid_gland0.80919376
171MP0003935_abnormal_craniofacial_develop0.80563910
172MP0001188_hyperpigmentation0.79449551
173MP0005023_abnormal_wound_healing0.79308720
174MP0004381_abnormal_hair_follicle0.78470425
175MP0002089_abnormal_postnatal_growth/wei0.77435148
176MP0005595_abnormal_vascular_smooth0.76998825
177MP0002932_abnormal_joint_morphology0.76951905
178MP0003646_muscle_fatigue0.76212957
179MP0010630_abnormal_cardiac_muscle0.75783011
180MP0005390_skeleton_phenotype0.75729922
181MP0003690_abnormal_glial_cell0.72619277

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)4.86527624
2Type 1 muscle fiber predominance (HP:0003803)4.42566065
3Congenital stationary night blindness (HP:0007642)3.95440061
4Muscle fiber inclusion bodies (HP:0100299)3.91831522
5Nemaline bodies (HP:0003798)3.89086134
6Bony spicule pigmentary retinopathy (HP:0007737)3.84856367
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.78096371
8Distal lower limb muscle weakness (HP:0009053)3.74914875
9Obstructive sleep apnea (HP:0002870)3.67428273
10Eczematoid dermatitis (HP:0000976)3.66279352
11Myocardial infarction (HP:0001658)3.56692327
12Shallow orbits (HP:0000586)3.47515245
13Chorioretinal atrophy (HP:0000533)3.45003341
14Elevated erythrocyte sedimentation rate (HP:0003565)3.32375633
15Stomatitis (HP:0010280)3.30468885
16Myositis (HP:0100614)3.22213486
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14139985
18Orchitis (HP:0100796)3.11298205
19Abnormality of the fingertips (HP:0001211)3.09370789
20Abnormal rod and cone electroretinograms (HP:0008323)2.94712814
21Broad metatarsal (HP:0001783)2.85779647
22Protrusio acetabuli (HP:0003179)2.84956204
23Turricephaly (HP:0000262)2.84265373
24Myopathic facies (HP:0002058)2.84018219
25EMG: myopathic abnormalities (HP:0003458)2.82671922
26Recurrent fungal infections (HP:0002841)2.82241526
27Optic neuritis (HP:0100653)2.81414288
28Retrobulbar optic neuritis (HP:0100654)2.81414288
29Spontaneous hematomas (HP:0007420)2.80111022
30Increased density of long bones (HP:0006392)2.74850288
31Abnormality of skeletal muscle fiber size (HP:0012084)2.74527894
32Coronal craniosynostosis (HP:0004440)2.73654574
33Increased variability in muscle fiber diameter (HP:0003557)2.72807583
34Round ear (HP:0100830)2.72247341
35IgM deficiency (HP:0002850)2.69883717
36Bronchomalacia (HP:0002780)2.65512702
37Central scotoma (HP:0000603)2.62557999
38Scotoma (HP:0000575)2.61702727
39Persistence of primary teeth (HP:0006335)2.60194692
40Abnormality of the left ventricular outflow tract (HP:0011103)2.59255860
41Subaortic stenosis (HP:0001682)2.59255860
42Partial duplication of thumb phalanx (HP:0009944)2.57524062
43Gastrointestinal infarctions (HP:0005244)2.55981681
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.55268108
45Partial duplication of the phalanx of hand (HP:0009999)2.55172899
46Spinal rigidity (HP:0003306)2.54938661
47Interstitial pulmonary disease (HP:0006530)2.54672061
48Recurrent bacterial skin infections (HP:0005406)2.54117865
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.53385599
50Arterial thrombosis (HP:0004420)2.53380212
51Colitis (HP:0002583)2.52810260
52Exercise-induced myalgia (HP:0003738)2.52790117
53Xanthomatosis (HP:0000991)2.47422066
54Ulnar bowing (HP:0003031)2.46126298
55Recurrent viral infections (HP:0004429)2.46095259
56Autoimmune thrombocytopenia (HP:0001973)2.46090473
57Abnormality of the parietal bone (HP:0002696)2.45887524
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.45699733
59Pulmonary infiltrates (HP:0002113)2.45108298
60Exercise-induced muscle cramps (HP:0003710)2.44374831
61Hyperacusis (HP:0010780)2.42353181
62Abolished electroretinogram (ERG) (HP:0000550)2.41462433
63Inflammation of the large intestine (HP:0002037)2.41147370
64Chronic otitis media (HP:0000389)2.40791666
65Deep venous thrombosis (HP:0002625)2.39637462
66Keratoconjunctivitis sicca (HP:0001097)2.39308369
67Panhypogammaglobulinemia (HP:0003139)2.37948449
68T lymphocytopenia (HP:0005403)2.37479896
69Abnormality of macular pigmentation (HP:0008002)2.36347697
70Recurrent abscess formation (HP:0002722)2.34795917
71Vasculitis (HP:0002633)2.34622920
72Myoglobinuria (HP:0002913)2.34603795
73Aplasia involving bones of the upper limbs (HP:0009823)2.34086683
74Aplasia of the phalanges of the hand (HP:0009802)2.34086683
75Aplasia involving bones of the extremities (HP:0009825)2.34086683
76Nasal polyposis (HP:0100582)2.33391102
77Mildly elevated creatine phosphokinase (HP:0008180)2.33307840
78Gastrointestinal stroma tumor (HP:0100723)2.32965504
79Abnormality of T cell number (HP:0011839)2.32048284
80Broad face (HP:0000283)2.32025582
81Polycythemia (HP:0001901)2.29901759
82Muscle hypertrophy of the lower extremities (HP:0008968)2.27294142
83Pulmonary embolism (HP:0002204)2.27174757
84Cellulitis (HP:0100658)2.27139426
85Pustule (HP:0200039)2.26422230
86Depressed nasal tip (HP:0000437)2.26016999
87Peritonitis (HP:0002586)2.25335038
88Abnormality of the nasal mucosa (HP:0000433)2.25197738
89Dyschromatopsia (HP:0007641)2.24344347
90Increased IgE level (HP:0003212)2.24248434
91Hyporeflexia of lower limbs (HP:0002600)2.23366033
92Posterior subcapsular cataract (HP:0007787)2.22993007
93Gastrointestinal inflammation (HP:0004386)2.22503127
94Muscle fiber splitting (HP:0003555)2.21884834
95Severe combined immunodeficiency (HP:0004430)2.21716866
96Neck muscle weakness (HP:0000467)2.20381088
97Calcaneovalgus deformity (HP:0001848)2.17005830
98Bulbar palsy (HP:0001283)2.15233116
99Complement deficiency (HP:0004431)2.13231905
100Keratoconjunctivitis (HP:0001096)2.12953149
101Recurrent skin infections (HP:0001581)2.12870420
102Systemic lupus erythematosus (HP:0002725)2.12864949
103Cone-rod dystrophy (HP:0000548)2.10941245
104Gingival bleeding (HP:0000225)2.10869145
105Distal arthrogryposis (HP:0005684)2.10782227
106Neonatal short-limb short stature (HP:0008921)2.10266002
107Abnormality of the calf musculature (HP:0001430)2.10008655
108Pendular nystagmus (HP:0012043)2.10005965
109Distal lower limb amyotrophy (HP:0008944)2.09129348
110Hypoglycemic coma (HP:0001325)2.08861740
111Abnormality of T cells (HP:0002843)2.08562153
112Leukocytosis (HP:0001974)2.07143418
113Combined immunodeficiency (HP:0005387)2.05627453
114Ulnar deviation of the wrist (HP:0003049)2.05225714
115Difficulty running (HP:0009046)2.04875950
116Abnormality of the phalanges of the hallux (HP:0010057)2.03767090
117Macular degeneration (HP:0000608)2.03594836
118Rhabdomyolysis (HP:0003201)2.03413711
119Hyperlipoproteinemia (HP:0010980)2.02965012
120Sleep apnea (HP:0010535)2.01025251
121Joint hemorrhage (HP:0005261)1.99659620
122Cerebral aneurysm (HP:0004944)1.98953715
123Increased connective tissue (HP:0009025)1.98827438
124Emphysema (HP:0002097)1.98000168
125Thyroiditis (HP:0100646)1.96646918
126Subcapsular cataract (HP:0000523)1.96603625
127Hematochezia (HP:0002573)1.96566758
128Thin ribs (HP:0000883)1.96188012
129Mediastinal lymphadenopathy (HP:0100721)1.95611744
130Calf muscle hypertrophy (HP:0008981)1.94158562
131Attenuation of retinal blood vessels (HP:0007843)1.93726273
132Atrioventricular block (HP:0001678)1.93561359
133Meningitis (HP:0001287)1.92738475
134Aplasia of the musculature (HP:0100854)1.91748790
135Esophageal varix (HP:0002040)1.91134063
136Hemoptysis (HP:0002105)1.90968431
137Recurrent cutaneous fungal infections (HP:0011370)1.90531221
138Chronic mucocutaneous candidiasis (HP:0002728)1.90531221
139Abnormality of fatty-acid metabolism (HP:0004359)1.89982297
140Hypoplasia of the iris (HP:0007676)1.89191541
141Vascular tortuosity (HP:0004948)1.88733500
142Hypoalphalipoproteinemia (HP:0003233)1.88329622
143Fatigue (HP:0012378)1.87872395
144Recurrent bronchitis (HP:0002837)1.87695286
145Recurrent gram-negative bacterial infections (HP:0005420)1.86452013
146Progressive visual loss (HP:0000529)1.86191829
147Aortic aneurysm (HP:0004942)1.85955485
148Epistaxis (HP:0000421)1.85920070
149Split foot (HP:0001839)1.85115295
150Abnormality of eosinophils (HP:0001879)1.84704943
151Abnormal platelet function (HP:0011869)1.83932738
152Abnormal atrioventricular conduction (HP:0005150)1.82991866
153Choanal stenosis (HP:0000452)1.82915820
154Axonal loss (HP:0003447)1.81732070
155Progressive muscle weakness (HP:0003323)1.81664360
156Absent phalangeal crease (HP:0006109)1.81132746
157Arnold-Chiari malformation (HP:0002308)1.80510105
158Achilles tendon contracture (HP:0001771)1.79958926
159Deformed tarsal bones (HP:0008119)1.76782886
160Diaphragmatic weakness (HP:0009113)1.76359123
161Premature rupture of membranes (HP:0001788)1.74558881
162Mitral regurgitation (HP:0001653)1.73887030
163Heart block (HP:0012722)1.73432810
164Asymmetric septal hypertrophy (HP:0001670)1.73109464
165Right ventricular cardiomyopathy (HP:0011663)1.72549988
166Limb-girdle muscle atrophy (HP:0003797)1.72356720
167Arterial tortuosity (HP:0005116)1.72348701
168Hyperkalemia (HP:0002153)1.71676259
169Muscle stiffness (HP:0003552)1.71594784
170Maternal diabetes (HP:0009800)1.71071012
171Generalized amyotrophy (HP:0003700)1.69356369
172Nasolacrimal duct obstruction (HP:0000579)1.68655010
173Sudden death (HP:0001699)1.67648542
174Difficulty climbing stairs (HP:0003551)1.67615708
175Skin pits (HP:0100276)1.67124135
176Camptodactyly of toe (HP:0001836)1.66584246
177Cerebral inclusion bodies (HP:0100314)1.66536050
178Bladder diverticulum (HP:0000015)1.66504159
179Laryngomalacia (HP:0001601)1.65546970
180Stridor (HP:0010307)1.65523565
181Bundle branch block (HP:0011710)1.64743733
182Lower limb amyotrophy (HP:0007210)1.64504931
183Abnormality of the salivary glands (HP:0010286)1.64246396
184Ventricular tachycardia (HP:0004756)1.63718209
185Scapular winging (HP:0003691)1.63639327
186Overriding aorta (HP:0002623)1.63621016
187Slender build (HP:0001533)1.61331523
188Athetosis (HP:0002305)1.61144955
189Bell-shaped thorax (HP:0001591)1.61025791
190EMG: neuropathic changes (HP:0003445)1.60665173
191Bifid scrotum (HP:0000048)1.60229330
192Germ cell neoplasia (HP:0100728)1.59413002
193Taurodontia (HP:0000679)1.58700870
194Abnormality of permanent molar morphology (HP:0011071)1.58700870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.05167875
2TXK2.70869810
3PRPF4B2.67448946
4MAP3K142.65167293
5EPHB12.62150310
6EPHA22.49406216
7TRIB32.42267578
8EEF2K2.26991915
9LATS22.24656731
10OBSCN2.24325345
11TAOK32.19915035
12SMG12.19760861
13ITK2.06265241
14ERN12.06250099
15STK102.01828603
16MAP3K102.01493017
17TYK21.96133256
18JAK31.94935296
19IRAK31.93567790
20TGFBR21.92345188
21FGFR41.83336065
22IKBKB1.82219611
23TBK11.81436100
24SIK11.80277829
25AKT31.77349824
26CHUK1.77343708
27IKBKE1.71775887
28EPHB21.68786554
29JAK11.67238761
30ICK1.65411288
31TTN1.63868114
32CDK121.61343117
33MAP2K31.60541857
34NLK1.59170618
35EPHA31.58299270
36PDGFRA1.49685255
37ZAP701.45805556
38PHKG21.39504763
39PHKG11.39504763
40BRD41.28060935
41FGFR31.25749939
42GRK61.21880952
43PIM11.21092964
44TEC1.18699206
45CAMK1D1.18256161
46MAPK151.16637695
47PTK61.16035422
48CSK1.15315690
49BTK1.13790291
50PKN21.12319299
51PNCK1.12002955
52MAP3K31.11904364
53UHMK11.09464782
54DDR21.09034950
55RPS6KC11.09026410
56RPS6KL11.09026410
57HIPK21.08184551
58PTK21.06999994
59DMPK1.06701439
60RPS6KA21.05369362
61NTRK11.02837775
62SGK2231.02170532
63SGK4941.02170532
64RPS6KA41.01161852
65CAMK1G0.98005201
66JAK20.96843548
67PRKAA20.94336636
68TAOK20.94218053
69IRAK40.93745624
70MARK10.93454898
71CDK90.93314213
72LRRK20.92879120
73HCK0.92853695
74MAP3K70.91824149
75KIT0.90942873
76GRK10.89945787
77LCK0.89415164
78RIPK10.88347694
79TRPM70.88061379
80PKN10.87278627
81PAK20.86598377
82TAOK10.84908780
83CLK10.82344433
84TYRO30.81911413
85DYRK1B0.81574345
86CSF1R0.80641204
87DYRK30.80632609
88TSSK60.78977232
89ROCK20.78451076
90MAPK70.77682969
91PDGFRB0.77305928
92MARK30.76862010
93GSK3A0.75947967
94MAPK120.75442520
95PRKD20.73430239
96PRKCH0.72645061
97RPS6KA50.72444396
98IRAK10.70503435
99SGK30.70028552
100BMX0.67626038
101SYK0.66717053
102AKT20.64332758
103PRKCQ0.62926897
104RPS6KA10.62576569
105CAMK2G0.61405878
106CDC42BPA0.61315632
107ABL20.60251077
108PRKD30.58326486
109NEK90.57872620
110KSR20.57617284
111MAP3K90.57448166
112MAPKAPK30.56400911
113MAPKAPK20.56175546
114CAMK40.55952282
115CAMK10.55728274
116MAPK100.52472683
117MTOR0.52121253
118PRKD10.51341788
119MAP2K20.50995815
120MKNK20.50917595
121FGFR20.50745814
122MAP3K130.50029980
123CAMK2B0.49197102
124WEE10.48542649
125MELK0.47925009
126BLK0.47886527
127STK240.47695101
128CDK60.47392601
129PDPK10.47155450
130SIK20.45750632
131SGK10.45718742
132PAK60.45304070
133IRAK20.44837190
134NTRK20.44586962
135MAPK40.43990276
136KDR0.43176000
137PIM20.40898977
138RPS6KA60.39947532
139LATS10.39832850
140MARK20.39044440
141STK110.39008817
142CAMK2D0.38878554
143PDK10.38697747
144BCKDK0.38508305
145MAPKAPK50.38004797
146STK40.37759498
147ROCK10.37324190
148MAPK30.37318726
149SGK20.37257136
150MAP3K10.36751542
151STK380.36137051
152MAPK90.35540556
153WNK10.35278706
154ABL10.34369172
155NME10.34256143
156PAK40.33287181

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.95747120
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49336731
3Osteoclast differentiation_Homo sapiens_hsa043802.41912843
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.34122997
5Primary immunodeficiency_Homo sapiens_hsa053402.30844526
6Staphylococcus aureus infection_Homo sapiens_hsa051501.98196828
7B cell receptor signaling pathway_Homo sapiens_hsa046621.85963419
8Fatty acid degradation_Homo sapiens_hsa000711.85864939
9T cell receptor signaling pathway_Homo sapiens_hsa046601.85558757
10Leishmaniasis_Homo sapiens_hsa051401.84928341
11Basal cell carcinoma_Homo sapiens_hsa052171.83928231
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.80333054
13Dilated cardiomyopathy_Homo sapiens_hsa054141.74916422
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70402017
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66444673
16Tight junction_Homo sapiens_hsa045301.65075371
17Nitrogen metabolism_Homo sapiens_hsa009101.64083973
18Measles_Homo sapiens_hsa051621.61667763
19PPAR signaling pathway_Homo sapiens_hsa033201.54929880
20Toxoplasmosis_Homo sapiens_hsa051451.53849788
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52917696
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.52121153
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.48966598
24Acute myeloid leukemia_Homo sapiens_hsa052211.47500393
25TNF signaling pathway_Homo sapiens_hsa046681.47015025
26Caffeine metabolism_Homo sapiens_hsa002321.46804544
27Hedgehog signaling pathway_Homo sapiens_hsa043401.46678904
28Fatty acid metabolism_Homo sapiens_hsa012121.46131254
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44350062
30Sulfur relay system_Homo sapiens_hsa041221.43471752
31Prion diseases_Homo sapiens_hsa050201.38851079
32Lysine degradation_Homo sapiens_hsa003101.38262329
33Estrogen signaling pathway_Homo sapiens_hsa049151.37768116
34Hippo signaling pathway_Homo sapiens_hsa043901.37747890
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34664623
36Melanogenesis_Homo sapiens_hsa049161.34409597
37Insulin resistance_Homo sapiens_hsa049311.33835812
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33045116
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32075612
40Thyroid cancer_Homo sapiens_hsa052161.32013018
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31526429
42Adherens junction_Homo sapiens_hsa045201.30796647
43Phenylalanine metabolism_Homo sapiens_hsa003601.30461531
44Insulin signaling pathway_Homo sapiens_hsa049101.29207020
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27197719
46Endometrial cancer_Homo sapiens_hsa052131.26581265
47Propanoate metabolism_Homo sapiens_hsa006401.22968944
48ECM-receptor interaction_Homo sapiens_hsa045121.22105556
49MicroRNAs in cancer_Homo sapiens_hsa052061.20639889
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19998616
51Wnt signaling pathway_Homo sapiens_hsa043101.19728662
52Focal adhesion_Homo sapiens_hsa045101.18447467
53Circadian rhythm_Homo sapiens_hsa047101.17675005
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17356257
55Complement and coagulation cascades_Homo sapiens_hsa046101.17297435
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.16968841
57Bladder cancer_Homo sapiens_hsa052191.16815959
58Vitamin B6 metabolism_Homo sapiens_hsa007501.16278858
59Glucagon signaling pathway_Homo sapiens_hsa049221.15804896
60Antigen processing and presentation_Homo sapiens_hsa046121.15502769
61Amphetamine addiction_Homo sapiens_hsa050311.14801499
62Long-term potentiation_Homo sapiens_hsa047201.14635644
63ABC transporters_Homo sapiens_hsa020101.13717287
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13025074
65Chronic myeloid leukemia_Homo sapiens_hsa052201.12594710
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12515658
67Bile secretion_Homo sapiens_hsa049761.12381880
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12258295
69Cocaine addiction_Homo sapiens_hsa050301.11913540
70Arginine and proline metabolism_Homo sapiens_hsa003301.10251448
71Tryptophan metabolism_Homo sapiens_hsa003801.09491765
72Malaria_Homo sapiens_hsa051441.08555409
73GnRH signaling pathway_Homo sapiens_hsa049121.06069355
74Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06038674
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04614798
76Arginine biosynthesis_Homo sapiens_hsa002201.04566724
77Proteoglycans in cancer_Homo sapiens_hsa052051.04019382
78Viral myocarditis_Homo sapiens_hsa054161.03533806
79Cardiac muscle contraction_Homo sapiens_hsa042601.00106887
80Prolactin signaling pathway_Homo sapiens_hsa049171.00096043
81Hepatitis B_Homo sapiens_hsa051610.99195978
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98637275
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.98607131
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98054200
85Fatty acid elongation_Homo sapiens_hsa000620.97599867
86ErbB signaling pathway_Homo sapiens_hsa040120.97162442
87Protein digestion and absorption_Homo sapiens_hsa049740.96886699
88Chemokine signaling pathway_Homo sapiens_hsa040620.96877985
89TGF-beta signaling pathway_Homo sapiens_hsa043500.96435037
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94540529
91Axon guidance_Homo sapiens_hsa043600.92528420
92Vitamin digestion and absorption_Homo sapiens_hsa049770.92440697
93Legionellosis_Homo sapiens_hsa051340.91706764
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91357522
95Fatty acid biosynthesis_Homo sapiens_hsa000610.91138587
96Influenza A_Homo sapiens_hsa051640.88998272
97Gastric acid secretion_Homo sapiens_hsa049710.88310030
98Retinol metabolism_Homo sapiens_hsa008300.87886381
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87698386
100Apoptosis_Homo sapiens_hsa042100.87457800
101Gap junction_Homo sapiens_hsa045400.87283623
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86891827
103Thyroid hormone synthesis_Homo sapiens_hsa049180.86654887
104Pancreatic cancer_Homo sapiens_hsa052120.86041827
105cAMP signaling pathway_Homo sapiens_hsa040240.85744609
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.84665434
107Notch signaling pathway_Homo sapiens_hsa043300.84528371
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84327612
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.84137870
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83597410
111Herpes simplex infection_Homo sapiens_hsa051680.83243132
112Allograft rejection_Homo sapiens_hsa053300.81064979
113Hematopoietic cell lineage_Homo sapiens_hsa046400.80048310
114Glioma_Homo sapiens_hsa052140.79860807
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79751308
116Small cell lung cancer_Homo sapiens_hsa052220.78896332
117Graft-versus-host disease_Homo sapiens_hsa053320.78437413
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77094275
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77015420
120Pertussis_Homo sapiens_hsa051330.76906591
121Pathways in cancer_Homo sapiens_hsa052000.76876784
122Oxytocin signaling pathway_Homo sapiens_hsa049210.76857237
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74799947
124Platelet activation_Homo sapiens_hsa046110.73921886
125beta-Alanine metabolism_Homo sapiens_hsa004100.72882950
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72531883
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72221701
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69500986
129Hepatitis C_Homo sapiens_hsa051600.69361834
130Tuberculosis_Homo sapiens_hsa051520.69219225
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67959039
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.67018035
133Starch and sucrose metabolism_Homo sapiens_hsa005000.66369358
134FoxO signaling pathway_Homo sapiens_hsa040680.66142969
135Rap1 signaling pathway_Homo sapiens_hsa040150.65482212
136Glycerolipid metabolism_Homo sapiens_hsa005610.65243080
137Melanoma_Homo sapiens_hsa052180.65168506
138Choline metabolism in cancer_Homo sapiens_hsa052310.63945618
139Dorso-ventral axis formation_Homo sapiens_hsa043200.63497330
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62895210
141Peroxisome_Homo sapiens_hsa041460.62502720
142Colorectal cancer_Homo sapiens_hsa052100.62306718
143Renal cell carcinoma_Homo sapiens_hsa052110.60094959
144MAPK signaling pathway_Homo sapiens_hsa040100.59190072
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59170158
146Non-small cell lung cancer_Homo sapiens_hsa052230.58910004
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58698202
148Autoimmune thyroid disease_Homo sapiens_hsa053200.58660681
149Fructose and mannose metabolism_Homo sapiens_hsa000510.57982193
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55773581
151Chemical carcinogenesis_Homo sapiens_hsa052040.55623221
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55265331
153Renin secretion_Homo sapiens_hsa049240.54827577
154HTLV-I infection_Homo sapiens_hsa051660.54827142
155AMPK signaling pathway_Homo sapiens_hsa041520.54126089
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.53549839
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51587573
158Calcium signaling pathway_Homo sapiens_hsa040200.51474623
159Sphingolipid metabolism_Homo sapiens_hsa006000.51397516
160PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51168184
161Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50732375
162VEGF signaling pathway_Homo sapiens_hsa043700.49465875
163Amoebiasis_Homo sapiens_hsa051460.48692894
164Fat digestion and absorption_Homo sapiens_hsa049750.47158428
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44112638
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.44037996
167Type II diabetes mellitus_Homo sapiens_hsa049300.42966631
168Prostate cancer_Homo sapiens_hsa052150.41087068
169Shigellosis_Homo sapiens_hsa051310.40716303
170Histidine metabolism_Homo sapiens_hsa003400.40348120
171Butanoate metabolism_Homo sapiens_hsa006500.39474407
172Salmonella infection_Homo sapiens_hsa051320.36686632

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »