ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.21889101
2	regulation of DNA endoreduplication (GO:0032875)	3.90848748
3	ribosome assembly (GO:0042255)	3.80213855
4	regulation of translational fidelity (GO:0006450)	3.73981963
5	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.73401575
6	Golgi transport vesicle coating (GO:0048200)	3.71309077
7	COPI coating of Golgi vesicle (GO:0048205)	3.71309077
8	mitochondrial RNA metabolic process (GO:0000959)	3.57405409
9	protein maturation by protein folding (GO:0022417)	3.52408187
10	DNA strand elongation involved in DNA replication (GO:0006271)	3.50997827
11	DNA strand elongation (GO:0022616)	3.48816674
12	DNA replication checkpoint (GO:0000076)	3.46270180
13	base-excision repair, AP site formation (GO:0006285)	3.44505470
14	proline biosynthetic process (GO:0006561)	3.40780148
15	pyrimidine nucleotide catabolic process (GO:0006244)	3.38707971
16	telomere maintenance via semi-conservative replication (GO:0032201)	3.35303844
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.34323736
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.34323736
19	formation of translation preinitiation complex (GO:0001731)	3.33080216
20	viral mRNA export from host cell nucleus (GO:0046784)	3.29544708
21	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.28442088
22	amino acid activation (GO:0043038)	3.28254894
23	tRNA aminoacylation (GO:0043039)	3.28254894
24	tRNA aminoacylation for protein translation (GO:0006418)	3.26196957
25	positive regulation of cell cycle checkpoint (GO:1901978)	3.25953212
26	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.23529229
27	protein localization to chromosome, centromeric region (GO:0071459)	3.21273615
28	purine nucleobase biosynthetic process (GO:0009113)	3.21244610
29	DNA unwinding involved in DNA replication (GO:0006268)	3.17524582
30	DNA replication-dependent nucleosome organization (GO:0034723)	3.15533088
31	DNA replication-dependent nucleosome assembly (GO:0006335)	3.15533088
32	regulation of spindle checkpoint (GO:0090231)	3.12701929
33	tRNA methylation (GO:0030488)	3.10311854
34	establishment of integrated proviral latency (GO:0075713)	3.07695028
35	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.07610886
36	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.06260504
37	GMP metabolic process (GO:0046037)	3.02795035
38	regulation of mitochondrial translation (GO:0070129)	2.99063759
39	protein localization to kinetochore (GO:0034501)	2.99015717
40	regulation of helicase activity (GO:0051095)	2.98552478
41	mitochondrial DNA metabolic process (GO:0032042)	2.97767318
42	rRNA transcription (GO:0009303)	2.97724975
43	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.97324076
44	ribosome biogenesis (GO:0042254)	2.90507863
45	mitotic sister chromatid segregation (GO:0000070)	2.89800064
46	nucleotide transmembrane transport (GO:1901679)	2.89713038
47	facial nerve structural organization (GO:0021612)	2.89212968
48	transcription-coupled nucleotide-excision repair (GO:0006283)	2.87882197
49	nucleobase biosynthetic process (GO:0046112)	2.86183740
50	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.85662594
51	oxidative phosphorylation (GO:0006119)	2.84526612
52	meiotic chromosome segregation (GO:0045132)	2.82719257
53	transcription from mitochondrial promoter (GO:0006390)	2.81716815
54	telomere maintenance via recombination (GO:0000722)	2.81436602
55	guanosine-containing compound biosynthetic process (GO:1901070)	2.81108293
56	regulation of translational elongation (GO:0006448)	2.81063003
57	mitotic nuclear envelope reassembly (GO:0007084)	2.79807606
58	nuclear envelope reassembly (GO:0031468)	2.79807606
59	fatty acid elongation (GO:0030497)	2.79217462
60	regulation of cardioblast proliferation (GO:0003264)	2.78021704
61	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.78021704
62	DNA replication initiation (GO:0006270)	2.77285555
63	UTP biosynthetic process (GO:0006228)	2.77274958
64	hepatocyte differentiation (GO:0070365)	2.75726655
65	negative regulation of ligase activity (GO:0051352)	2.75034351
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.75034351
67	mitotic chromosome condensation (GO:0007076)	2.74379769
68	proteasome assembly (GO:0043248)	2.73985163
69	nucleobase-containing small molecule interconversion (GO:0015949)	2.73782803
70	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73743447
71	adenosine metabolic process (GO:0046085)	2.71693818
72	histone H2A acetylation (GO:0043968)	2.70388038
73	rRNA modification (GO:0000154)	2.70267463
74	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.68965574
75	pseudouridine synthesis (GO:0001522)	2.68840389
76	L-methionine salvage (GO:0071267)	2.68453663
77	L-methionine biosynthetic process (GO:0071265)	2.68453663
78	amino acid salvage (GO:0043102)	2.68453663
79	mitotic recombination (GO:0006312)	2.67672926
80	peptidyl-histidine modification (GO:0018202)	2.67627375
81	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.66532415
82	sister chromatid segregation (GO:0000819)	2.66529979
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65637201
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64454491
85	ribonucleoprotein complex biogenesis (GO:0022613)	2.61609327
86	protein deneddylation (GO:0000338)	2.60302854
87	UTP metabolic process (GO:0046051)	2.59964353
88	deoxyribose phosphate biosynthetic process (GO:0046385)	2.59766535
89	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.59766535
90	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.59384934
91	GTP biosynthetic process (GO:0006183)	2.59227762
92	regulation of cellular amino acid metabolic process (GO:0006521)	2.59139270
93	L-serine metabolic process (GO:0006563)	2.58522589
94	C-terminal protein lipidation (GO:0006501)	2.57102721
95	tricarboxylic acid cycle (GO:0006099)	2.56768904
96	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.56647727
97	establishment of viral latency (GO:0019043)	2.56598686
98	CTP biosynthetic process (GO:0006241)	2.55737590
99	CTP metabolic process (GO:0046036)	2.55737590
100	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.55061486

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.81266141
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.98359543
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.62144290
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.41700736
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.33258123
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.26322005
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.26174199
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.08083075
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.99800420
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.87965216
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.80216562
12	DCP1A_22483619_ChIP-Seq_HELA_Human	2.71255086
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.70547939
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.60263455
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.53252985
16	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.52390959
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44582749
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.44026491
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.41155768
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.40169515
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.36012370
22	GABP_19822575_ChIP-Seq_HepG2_Human	2.31413929
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.29938762
24	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.20841319
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.20136580
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.18290252
27	AR_21909140_ChIP-Seq_LNCAP_Human	2.17402841
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.07452340
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.03492564
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.00557101
31	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.98674373
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98110805
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.90307563
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90141660
35	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.88508245
36	ZNF263_19887448_ChIP-Seq_K562_Human	1.84285274
37	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.77095815
38	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.75774519
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.72914280
40	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.69028147
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64201497
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.64104348
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.61354768
44	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59850823
45	KDM5A_27292631_Chip-Seq_BREAST_Human	1.59538177
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.54324975
47	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.54248532
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49863692
49	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46766723
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45312300
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.45225536
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.44747102
53	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.43309904
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42469534
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.40885094
56	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.40221531
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.39464121
58	TFEB_21752829_ChIP-Seq_HELA_Human	1.38977208
59	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.38878254
60	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37177617
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36305751
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.35821574
63	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.33603336
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32373851
65	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.28856884
66	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.25734450
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23232154
68	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.22766092
69	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21414300
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.21211927
71	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.20665095
72	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.18348745
73	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17665309
74	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.15371484
75	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.14884202
76	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.14807049
77	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14149304
78	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.08747785
79	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.06733049
80	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.05696775
81	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.04599536
82	ATF3_27146783_Chip-Seq_COLON_Human	1.02596702
83	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.01264935
84	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00951603
85	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.00749540
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00405129
87	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.00037267
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.99942379
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99220854
90	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98856200
91	MYC_18940864_ChIP-ChIP_HL60_Human	0.98177443
92	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.97950335
93	VDR_21846776_ChIP-Seq_THP-1_Human	0.94940225
94	CIITA_25753668_ChIP-Seq_RAJI_Human	0.94125792
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93248726
96	CHD1_26751641_Chip-Seq_LNCaP_Human	0.92766987
97	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92196706
98	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.91125980
99	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88690474
100	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.88093414

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.34368549
2	MP0003693_abnormal_embryo_hatching	3.20679564
3	MP0004957_abnormal_blastocyst_morpholog	3.11109375
4	MP0010234_abnormal_vibrissa_follicle	3.02978627
5	MP0003111_abnormal_nucleus_morphology	3.02953234
6	MP0010030_abnormal_orbit_morphology	2.78387273
7	MP0005451_abnormal_body_composition	2.73122867
8	MP0008932_abnormal_embryonic_tissue	2.72661540
9	MP0010094_abnormal_chromosome_stability	2.55362396
10	MP0002822_catalepsy	2.53837275
11	MP0003077_abnormal_cell_cycle	2.51677210
12	MP0009840_abnormal_foam_cell	2.50974290
13	MP0002653_abnormal_ependyma_morphology	2.33409114
14	MP0004233_abnormal_muscle_weight	2.25231621
15	MP0008007_abnormal_cellular_replicative	2.13886638
16	MP0008789_abnormal_olfactory_epithelium	2.10206160
17	MP0002254_reproductive_system_inflammat	2.06390999
18	MP0003786_premature_aging	1.87526507
19	MP0005083_abnormal_biliary_tract	1.84608387
20	MP0001730_embryonic_growth_arrest	1.73345735
21	MP0002139_abnormal_hepatobiliary_system	1.70203666
22	MP0005501_abnormal_skin_physiology	1.67497888
23	MP0004147_increased_porphyrin_level	1.67325717
24	MP0000678_abnormal_parathyroid_gland	1.65550491
25	MP0009697_abnormal_copulation	1.61386995
26	MP0006054_spinal_hemorrhage	1.56771290
27	MP0000566_synostosis	1.56565589
28	MP0003718_maternal_effect	1.52723682
29	MP0001727_abnormal_embryo_implantation	1.49763728
30	MP0000350_abnormal_cell_proliferation	1.48344710
31	MP0005220_abnormal_exocrine_pancreas	1.48065602
32	MP0001529_abnormal_vocalization	1.47412228
33	MP0005499_abnormal_olfactory_system	1.46871088
34	MP0005394_taste/olfaction_phenotype	1.46871088
35	MP0010368_abnormal_lymphatic_system	1.46794584
36	MP0004272_abnormal_basement_membrane	1.45933890
37	MP0005623_abnormal_meninges_morphology	1.41347338
38	MP0006292_abnormal_olfactory_placode	1.38838751
39	MP0001881_abnormal_mammary_gland	1.31693663
40	MP0002269_muscular_atrophy	1.30413451
41	MP0003806_abnormal_nucleotide_metabolis	1.30289787
42	MP0004808_abnormal_hematopoietic_stem	1.28790152
43	MP0002132_abnormal_respiratory_system	1.23229260
44	MP0002080_prenatal_lethality	1.22632399
45	MP0002877_abnormal_melanocyte_morpholog	1.22284006
46	MP0000358_abnormal_cell_content/	1.22195522
47	MP0009250_abnormal_appendicular_skeleto	1.21566796
48	MP0002796_impaired_skin_barrier	1.21499494
49	MP0003186_abnormal_redox_activity	1.20366787
50	MP0001697_abnormal_embryo_size	1.20340801
51	MP0000749_muscle_degeneration	1.20106457
52	MP0002249_abnormal_larynx_morphology	1.18653611
53	MP0000313_abnormal_cell_death	1.15514083
54	MP0002234_abnormal_pharynx_morphology	1.14185304
55	MP0001764_abnormal_homeostasis	1.13101374
56	MP0000490_abnormal_crypts_of	1.12985139
57	MP0001243_abnormal_dermal_layer	1.07361518
58	MP0006036_abnormal_mitochondrial_physio	1.05837443
59	MP0005380_embryogenesis_phenotype	1.04220303
60	MP0001672_abnormal_embryogenesis/_devel	1.04220303
61	MP0002060_abnormal_skin_morphology	1.02398342
62	MP0005408_hypopigmentation	1.00073006
63	MP0002085_abnormal_embryonic_tissue	1.00035048
64	MP0005058_abnormal_lysosome_morphology	0.99584602
65	MP0003755_abnormal_palate_morphology	0.98672065
66	MP0000428_abnormal_craniofacial_morphol	0.97547235
67	MP0003191_abnormal_cellular_cholesterol	0.97079645
68	MP0006072_abnormal_retinal_apoptosis	0.96729947
69	MP0004185_abnormal_adipocyte_glucose	0.95891942
70	MP0003984_embryonic_growth_retardation	0.91520556
71	MP0009053_abnormal_anal_canal	0.91130003
72	MP0000733_abnormal_muscle_development	0.88802740
73	MP0002088_abnormal_embryonic_growth/wei	0.88518145
74	MP0002697_abnormal_eye_size	0.88467488
75	MP0003942_abnormal_urinary_system	0.87625619
76	MP0006035_abnormal_mitochondrial_morpho	0.87548630
77	MP0002210_abnormal_sex_determination	0.87468586
78	MP0008438_abnormal_cutaneous_collagen	0.87386924
79	MP0001340_abnormal_eyelid_morphology	0.87037395
80	MP0003221_abnormal_cardiomyocyte_apopto	0.86435249
81	MP0000627_abnormal_mammary_gland	0.84395705
82	MP0003385_abnormal_body_wall	0.83774067
83	MP0002163_abnormal_gland_morphology	0.83664283
84	MP0002086_abnormal_extraembryonic_tissu	0.82154318
85	MP0004197_abnormal_fetal_growth/weight/	0.81214944
86	MP0003936_abnormal_reproductive_system	0.80543256
87	MP0009379_abnormal_foot_pigmentation	0.77302278
88	MP0002084_abnormal_developmental_patter	0.76600890
89	MP0003566_abnormal_cell_adhesion	0.76544278
90	MP0003937_abnormal_limbs/digits/tail_de	0.76382521
91	MP0005384_cellular_phenotype	0.76298849
92	MP0001929_abnormal_gametogenesis	0.75294745
93	MP0008057_abnormal_DNA_replication	0.74672212
94	MP0002282_abnormal_trachea_morphology	0.74535746
95	MP0005248_abnormal_Harderian_gland	0.73123633
96	MP0005621_abnormal_cell_physiology	0.72826069
97	MP0004858_abnormal_nervous_system	0.72657177
98	MP0002111_abnormal_tail_morphology	0.70587250
99	MP0000762_abnormal_tongue_morphology	0.69636964
100	MP0002751_abnormal_autonomic_nervous	0.69009552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septate vagina (HP:0001153)	3.63863223
2	Overlapping toe (HP:0001845)	3.58999057
3	Lipid accumulation in hepatocytes (HP:0006561)	3.13607985
4	Abnormal protein glycosylation (HP:0012346)	3.13196405
5	Abnormal glycosylation (HP:0012345)	3.13196405
6	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.13196405
7	Abnormal protein N-linked glycosylation (HP:0012347)	3.13196405
8	Abnormal umbilical cord blood vessels (HP:0011403)	3.12629791
9	Single umbilical artery (HP:0001195)	3.12629791
10	Abnormality of the fetal cardiovascular system (HP:0010948)	3.12629791
11	Unilateral renal agenesis (HP:0000122)	2.98445696
12	Abnormality of the umbilical cord (HP:0010881)	2.80964709
13	Increased hepatocellular lipid droplets (HP:0006565)	2.65558352
14	Increased muscle lipid content (HP:0009058)	2.61091548
15	Abnormality of glycolysis (HP:0004366)	2.61049749
16	Renal Fanconi syndrome (HP:0001994)	2.58619119
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.55929822
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.55929822
19	Abnormalities of placenta or umbilical cord (HP:0001194)	2.55750365
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.53541472
21	Increased intramyocellular lipid droplets (HP:0012240)	2.50574098
22	Mitochondrial inheritance (HP:0001427)	2.48708260
23	Increased CSF lactate (HP:0002490)	2.48119159
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.45199875
25	Hepatocellular necrosis (HP:0001404)	2.42519437
26	Orthostatic hypotension (HP:0001278)	2.35639498
27	Hypokinesia (HP:0002375)	2.35130298
28	Acute encephalopathy (HP:0006846)	2.30296195
29	Type I transferrin isoform profile (HP:0003642)	2.30097757
30	Exertional dyspnea (HP:0002875)	2.28514539
31	Cholecystitis (HP:0001082)	2.28327792
32	Abnormal gallbladder physiology (HP:0012438)	2.28327792
33	Increased serum pyruvate (HP:0003542)	2.26612032
34	Increased nuchal translucency (HP:0010880)	2.25756689
35	Sparse lateral eyebrow (HP:0005338)	2.24231583
36	Premature rupture of membranes (HP:0001788)	2.24197521
37	Acute necrotizing encephalopathy (HP:0006965)	2.22054118
38	Multiple enchondromatosis (HP:0005701)	2.20955122
39	Trismus (HP:0000211)	2.20458994
40	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.20300090
41	Proximal placement of thumb (HP:0009623)	2.18966619
42	Neoplasm of head and neck (HP:0012288)	2.16723187
43	Esophageal neoplasm (HP:0100751)	2.16723187
44	Breech presentation (HP:0001623)	2.16528163
45	Abnormality of the distal phalanges of the toes (HP:0010182)	2.15777279
46	Reduced subcutaneous adipose tissue (HP:0003758)	2.13379824
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.11523453
48	Abnormality of methionine metabolism (HP:0010901)	2.09794952
49	Chromsome breakage (HP:0040012)	2.09269926
50	Abnormality of placental membranes (HP:0011409)	2.08608634
51	Amniotic constriction ring (HP:0009775)	2.08608634
52	Increased serum lactate (HP:0002151)	2.07874291
53	Ragged-red muscle fibers (HP:0003200)	2.07523517
54	Long palpebral fissure (HP:0000637)	2.05119605
55	Secondary amenorrhea (HP:0000869)	2.04409026
56	Gout (HP:0001997)	2.04046040
57	Birth length less than 3rd percentile (HP:0003561)	2.03546396
58	Upper limb muscle weakness (HP:0003484)	2.03155070
59	Premature ovarian failure (HP:0008209)	1.99974147
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99701606
61	Slender long bone (HP:0003100)	1.98565294
62	Truncus arteriosus (HP:0001660)	1.96744943
63	Hepatic necrosis (HP:0002605)	1.95373850
64	Cerebral edema (HP:0002181)	1.95153100
65	Abnormality of the preputium (HP:0100587)	1.93705605
66	Deviation of the thumb (HP:0009603)	1.93639487
67	Exercise intolerance (HP:0003546)	1.92451164
68	Lactic acidosis (HP:0003128)	1.90977116
69	Vertebral compression fractures (HP:0002953)	1.90570495
70	Death in infancy (HP:0001522)	1.88341873
71	Sparse eyelashes (HP:0000653)	1.88325123
72	Anal atresia (HP:0002023)	1.88215629
73	Dysautonomia (HP:0002459)	1.88071509
74	Redundant skin (HP:0001582)	1.87572461
75	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.84413142
76	Short nail (HP:0001799)	1.84109313
77	Progressive muscle weakness (HP:0003323)	1.83533444
78	Microretrognathia (HP:0000308)	1.82808765
79	Testicular atrophy (HP:0000029)	1.80129769
80	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.78727406
81	Hyperammonemia (HP:0001987)	1.78409144
82	Ependymoma (HP:0002888)	1.77679714
83	Atelectasis (HP:0100750)	1.76848538
84	Reticulocytopenia (HP:0001896)	1.76170260
85	Insomnia (HP:0100785)	1.76105148
86	Entropion (HP:0000621)	1.74919422
87	Renal duplication (HP:0000075)	1.74289946
88	Male infertility (HP:0003251)	1.73657737
89	Alopecia of scalp (HP:0002293)	1.73323647
90	Anal stenosis (HP:0002025)	1.72359229
91	Sloping forehead (HP:0000340)	1.72035928
92	Meckel diverticulum (HP:0002245)	1.71482192
93	Spastic paraparesis (HP:0002313)	1.70669252
94	Emotional lability (HP:0000712)	1.70520266
95	Abnormality of reticulocytes (HP:0004312)	1.70224421
96	Rib fusion (HP:0000902)	1.70068709
97	Micronodular cirrhosis (HP:0001413)	1.68653545
98	Reticulocytosis (HP:0001923)	1.67407971
99	Recurrent corneal erosions (HP:0000495)	1.66487689
100	Myocardial infarction (HP:0001658)	1.65775800

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	3.71959239
2	ARAF	3.68807819
3	NME2	3.39748677
4	MAP3K13	2.97555303
5	BUB1	2.89268708
6	ZAK	2.75483355
7	SRPK1	2.53225036
8	IRAK3	2.45826445
9	SCYL2	2.20270345
10	STK16	2.19884591
11	VRK2	2.18625492
12	EPHA2	2.18154678
13	MST4	2.15756905
14	RAF1	2.04847639
15	NEK1	1.97492528
16	PBK	1.95754200
17	CCNB1	1.94236919
18	TESK2	1.82494910
19	PIM2	1.80077822
20	TLK1	1.78866116
21	BCKDK	1.78052196
22	KSR2	1.72942803
23	DYRK3	1.59404878
24	TTK	1.59343408
25	TESK1	1.57930344
26	PAK4	1.56119289
27	EIF2AK1	1.54383936
28	BRAF	1.49552416
29	SMG1	1.40666742
30	LIMK1	1.40639617
31	CDC7	1.37803610
32	TRIM28	1.35607045
33	WEE1	1.25737757
34	MAP3K8	1.22871295
35	NUAK1	1.21981789
36	EEF2K	1.18073234
37	TRPM7	1.13807615
38	CHEK2	1.13409978
39	CSNK1G3	1.11350358
40	MET	1.07935454
41	AURKA	1.07879606
42	LATS1	1.05353934
43	ICK	1.01981203
44	SIK3	1.01867760
45	CSNK1A1L	1.00040307
46	GRK1	0.97881148
47	CDK8	0.95754827
48	CDK12	0.94892596
49	PDK2	0.93148704
50	MOS	0.92815217
51	MST1R	0.91783297
52	KSR1	0.91746657
53	ILK	0.89770972
54	AURKB	0.88455664
55	PLK1	0.87015658
56	CDK7	0.86972917
57	VRK1	0.81257417
58	MAP2K7	0.78059212
59	CHEK1	0.77923842
60	NTRK1	0.77168693
61	MAP3K14	0.72130546
62	CLK1	0.71909404
63	AKT2	0.71285421
64	NME1	0.70430874
65	ERBB4	0.69270432
66	ERN1	0.67024867
67	PLK4	0.65677067
68	ATR	0.64969621
69	TRIB3	0.64256607
70	ERBB3	0.63391966
71	MAP2K2	0.63364863
72	CSNK1G1	0.62855733
73	MTOR	0.57587001
74	NEK2	0.56132003
75	EPHB2	0.54419338
76	BRSK1	0.53815977
77	BMPR2	0.53685300
78	PTK2	0.53014495
79	PAK1	0.52444116
80	BRSK2	0.51973317
81	MYLK	0.51791701
82	PRKCI	0.51464493
83	RPS6KA5	0.51413247
84	ADRBK2	0.50542145
85	PAK2	0.49904695
86	MAPK11	0.48608093
87	CDK9	0.48577846
88	CSNK1G2	0.48104922
89	PLK3	0.46627760
90	MELK	0.44205203
91	BCR	0.43648767
92	CSNK2A2	0.41448977
93	TAOK2	0.41406394
94	STK3	0.40670382
95	STK4	0.40407558
96	LRRK2	0.34976932
97	SIK1	0.34132907
98	FLT3	0.33818863
99	CSNK2A1	0.33794436
100	CDK1	0.33216792

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.34208917
2	Mismatch repair_Homo sapiens_hsa03430	3.12944064
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.12375996
4	Proteasome_Homo sapiens_hsa03050	2.95725021
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.66739725
6	RNA polymerase_Homo sapiens_hsa03020	2.47711499
7	Folate biosynthesis_Homo sapiens_hsa00790	2.21841545
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.20574891
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18794759
10	Sulfur relay system_Homo sapiens_hsa04122	2.18127046
11	Base excision repair_Homo sapiens_hsa03410	2.11186534
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.08003142
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.07367936
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.98290737
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94701571
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.92995522
17	Spliceosome_Homo sapiens_hsa03040	1.89960221
18	Protein export_Homo sapiens_hsa03060	1.85142452
19	Homologous recombination_Homo sapiens_hsa03440	1.83707361
20	Fatty acid elongation_Homo sapiens_hsa00062	1.79094976
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.72146840
22	Ribosome_Homo sapiens_hsa03010	1.69817374
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.69500629
24	One carbon pool by folate_Homo sapiens_hsa00670	1.67951534
25	RNA transport_Homo sapiens_hsa03013	1.67578087
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63022614
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59835105
28	Cell cycle_Homo sapiens_hsa04110	1.52112450
29	Carbon metabolism_Homo sapiens_hsa01200	1.51625356
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51144724
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.47690504
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.43664363
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.40877954
34	Parkinsons disease_Homo sapiens_hsa05012	1.36167568
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27999860
36	Galactose metabolism_Homo sapiens_hsa00052	1.26100597
37	Huntingtons disease_Homo sapiens_hsa05016	1.24521062
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.22624118
39	Purine metabolism_Homo sapiens_hsa00230	1.21183479
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.20225012
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.16354251
42	Pentose phosphate pathway_Homo sapiens_hsa00030	1.11263818
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09014758
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.02685712
45	Basal transcription factors_Homo sapiens_hsa03022	1.00437405
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00000055
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98841296
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96795369
49	Bladder cancer_Homo sapiens_hsa05219	0.95230323
50	Thyroid cancer_Homo sapiens_hsa05216	0.93629389
51	Glutathione metabolism_Homo sapiens_hsa00480	0.93118907
52	Lysine degradation_Homo sapiens_hsa00310	0.91497449
53	RNA degradation_Homo sapiens_hsa03018	0.90507625
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.89194766
55	Alcoholism_Homo sapiens_hsa05034	0.84463484
56	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.83812928
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83264541
58	Alzheimers disease_Homo sapiens_hsa05010	0.83085784
59	Sulfur metabolism_Homo sapiens_hsa00920	0.81407610
60	p53 signaling pathway_Homo sapiens_hsa04115	0.77869304
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75566137
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71566893
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69455039
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.68318728
65	Metabolic pathways_Homo sapiens_hsa01100	0.67269150
66	Propanoate metabolism_Homo sapiens_hsa00640	0.65719676
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64566166
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61143047
69	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.60889032
70	Other glycan degradation_Homo sapiens_hsa00511	0.59901466
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59809986
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59295264
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55643985
74	Oocyte meiosis_Homo sapiens_hsa04114	0.54640984
75	Viral carcinogenesis_Homo sapiens_hsa05203	0.52928307
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50878917
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.50557351
78	Small cell lung cancer_Homo sapiens_hsa05222	0.50532904
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49066088
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46708050
81	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.45925393
82	Pancreatic cancer_Homo sapiens_hsa05212	0.40911109
83	Non-small cell lung cancer_Homo sapiens_hsa05223	0.40682802
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40056695
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39020950
86	Shigellosis_Homo sapiens_hsa05131	0.38857219
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.38165517
88	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.35934569
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33188032
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32931519
91	Peroxisome_Homo sapiens_hsa04146	0.32254417
92	Fatty acid degradation_Homo sapiens_hsa00071	0.31918375
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29290700
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28514417
95	Melanoma_Homo sapiens_hsa05218	0.24560927
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.23345562
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23212290
98	Apoptosis_Homo sapiens_hsa04210	0.21729181
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21021113
100	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.20438278

TOB2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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