TOLLIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.34969835
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25508174
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24729711
4glutamate secretion (GO:0014047)4.01342124
5locomotory exploration behavior (GO:0035641)3.91149261
6L-amino acid import (GO:0043092)3.88590905
7regulation of synaptic vesicle exocytosis (GO:2000300)3.85504147
8synaptic vesicle exocytosis (GO:0016079)3.82227524
9sodium ion export (GO:0071436)3.80973799
10amino acid import (GO:0043090)3.75769888
11cellular potassium ion homeostasis (GO:0030007)3.62604829
12positive regulation of neurotransmitter secretion (GO:0001956)3.56278650
13activation of protein kinase A activity (GO:0034199)3.43827244
14regulation of synaptic vesicle transport (GO:1902803)3.38021208
15positive regulation of neurotransmitter transport (GO:0051590)3.28529135
16macroautophagy (GO:0016236)3.24227111
17layer formation in cerebral cortex (GO:0021819)3.19446028
18G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15644518
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13702314
20synaptic vesicle endocytosis (GO:0048488)3.11865400
21neurotransmitter secretion (GO:0007269)3.11588764
22neuronal ion channel clustering (GO:0045161)3.09072543
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.07133483
24vesicle transport along microtubule (GO:0047496)3.01277236
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97900692
26COPI coating of Golgi vesicle (GO:0048205)2.96241843
27Golgi transport vesicle coating (GO:0048200)2.96241843
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93469696
29proline transport (GO:0015824)2.92643583
30regulation of synapse structural plasticity (GO:0051823)2.92045847
31cell communication by electrical coupling (GO:0010644)2.89204602
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89005577
33regulation of ARF protein signal transduction (GO:0032012)2.88468486
34alanine transport (GO:0032328)2.87994239
35calcium ion-dependent exocytosis (GO:0017156)2.86801910
36positive regulation of membrane potential (GO:0045838)2.86565367
37positive regulation of dendritic spine development (GO:0060999)2.83012723
38potassium ion import (GO:0010107)2.80052044
39regulation of neuronal synaptic plasticity (GO:0048168)2.77058414
40regulation of voltage-gated calcium channel activity (GO:1901385)2.75686867
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75035163
42cerebellar Purkinje cell layer development (GO:0021680)2.70994388
43regulation of synapse maturation (GO:0090128)2.69452801
44dendritic spine organization (GO:0097061)2.67678661
45potassium ion homeostasis (GO:0055075)2.67278649
46exploration behavior (GO:0035640)2.66742925
47cerebellar granule cell differentiation (GO:0021707)2.65790787
48regulation of glutamate receptor signaling pathway (GO:1900449)2.65529211
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65041673
50dendritic spine morphogenesis (GO:0060997)2.64976717
51negative regulation of inclusion body assembly (GO:0090084)2.63842028
52vocalization behavior (GO:0071625)2.61080305
53acidic amino acid transport (GO:0015800)2.60231744
54regulation of early endosome to late endosome transport (GO:2000641)2.59515063
55adenosine receptor signaling pathway (GO:0001973)2.58853189
56vesicle docking involved in exocytosis (GO:0006904)2.58818210
57protein targeting to Golgi (GO:0000042)2.58781319
58gamma-aminobutyric acid transport (GO:0015812)2.58279338
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57582566
60neurotransmitter-gated ion channel clustering (GO:0072578)2.57298648
61regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56885729
62negative regulation of dendrite morphogenesis (GO:0050774)2.56459257
63regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55773004
64regulation of exocytosis (GO:0017157)2.53816004
65signal complex assembly (GO:0007172)2.53084608
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52909008
67positive regulation of vesicle fusion (GO:0031340)2.50691755
68membrane depolarization during action potential (GO:0086010)2.50281395
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49016460
70detection of calcium ion (GO:0005513)2.48706414
71long term synaptic depression (GO:0060292)2.48403422
72axon ensheathment in central nervous system (GO:0032291)2.47981241
73central nervous system myelination (GO:0022010)2.47981241
74membrane repolarization (GO:0086009)2.47808197
75neurotransmitter transport (GO:0006836)2.47735574
76positive regulation of protein dephosphorylation (GO:0035307)2.47652737
77chemosensory behavior (GO:0007635)2.45505879
78organelle transport along microtubule (GO:0072384)2.45214888
79dicarboxylic acid transport (GO:0006835)2.44659685
80establishment of protein localization to Golgi (GO:0072600)2.44468715
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44134319
82long-term memory (GO:0007616)2.44070692
83cell communication involved in cardiac conduction (GO:0086065)2.43897491
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.43191143
85neuromuscular process controlling balance (GO:0050885)2.40667683
86regulation of synaptic transmission (GO:0050804)2.40475577
87cerebellar Purkinje cell differentiation (GO:0021702)2.40287227
88neuromuscular process controlling posture (GO:0050884)2.40115622
89cellular sodium ion homeostasis (GO:0006883)2.39534282
90positive regulation of synapse maturation (GO:0090129)2.39148212
91regulation of neurotransmitter secretion (GO:0046928)2.39079497
92response to manganese ion (GO:0010042)2.38396350
93regulation of clathrin-mediated endocytosis (GO:2000369)2.38355195
94positive regulation of exocytosis (GO:0045921)2.37909109
95glycine transport (GO:0015816)2.37876565
96long-term synaptic potentiation (GO:0060291)2.37270463
97synaptic vesicle transport (GO:0048489)2.36805985
98establishment of synaptic vesicle localization (GO:0097480)2.36805985
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.35183706
100trivalent inorganic cation transport (GO:0072512)2.34807842
101ferric iron transport (GO:0015682)2.34807842
102synaptic transmission, glutamatergic (GO:0035249)2.30988414
103regulation of postsynaptic membrane potential (GO:0060078)2.30553609
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.29863529
105neuronal action potential propagation (GO:0019227)2.29061226
106regulation of synaptic plasticity (GO:0048167)2.28564212
107L-glutamate transport (GO:0015813)2.28528676
108barbed-end actin filament capping (GO:0051016)2.28380619
109ATP hydrolysis coupled proton transport (GO:0015991)2.27641938
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27641938
111acrosome reaction (GO:0007340)2.26733364
112insulin secretion (GO:0030073)2.26226216
113regulation of neurotransmitter levels (GO:0001505)2.25993380
114vesicle docking (GO:0048278)2.24751107
115regulation of neurotransmitter transport (GO:0051588)2.24574355
116membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.24028996
117response to dietary excess (GO:0002021)2.23755286
118dendrite morphogenesis (GO:0048813)2.23714912
119axon cargo transport (GO:0008088)2.22855368
120CDP-diacylglycerol metabolic process (GO:0046341)2.22651025
121regulation of regulated secretory pathway (GO:1903305)2.22260814
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.22260581
123positive regulation of Rap GTPase activity (GO:0032854)2.21962752
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.21953792
125protein localization to synapse (GO:0035418)2.21371321
126signal release (GO:0023061)2.21264973
127regulation of vesicle fusion (GO:0031338)2.21184049
128regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.20990067
129prepulse inhibition (GO:0060134)2.20580897
130sperm motility (GO:0030317)2.20406642
131neuron-neuron synaptic transmission (GO:0007270)2.19948444
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.17342809
133regulation of calcium ion-dependent exocytosis (GO:0017158)2.16759910
134transferrin transport (GO:0033572)2.16746941
135positive regulation of potassium ion transport (GO:0043268)2.16215545
136mating behavior (GO:0007617)2.15654122
137glutamate receptor signaling pathway (GO:0007215)2.14358669
138regulation of inclusion body assembly (GO:0090083)2.13764990
139regulation of microtubule-based movement (GO:0060632)2.12601628
140cellular response to glucagon stimulus (GO:0071377)2.12018322
141regulation of sodium ion transmembrane transporter activity (GO:2000649)2.11381567
142regulation of cholesterol homeostasis (GO:2000188)2.09219823
143behavioral response to cocaine (GO:0048148)2.08780340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.60393003
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19354346
3REST_21632747_ChIP-Seq_MESCs_Mouse2.11970740
4SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11211650
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.05760304
6DROSHA_22980978_ChIP-Seq_HELA_Human2.05530606
7MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99677438
8RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95059226
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87517009
10REST_18959480_ChIP-ChIP_MESCs_Mouse1.80094761
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79954469
12SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71675097
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67860214
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67464291
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66638145
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62581651
17GBX2_23144817_ChIP-Seq_PC3_Human1.61139691
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60408436
19KDM2B_26808549_Chip-Seq_DND41_Human1.60052532
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.58389408
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57380030
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55653189
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53892158
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52912865
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52912865
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.52192372
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.49619072
28KDM2B_26808549_Chip-Seq_K562_Human1.46008990
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45423454
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45260896
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45148129
32RACK7_27058665_Chip-Seq_MCF-7_Human1.42258322
33SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41454673
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40542612
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.39997808
36ZNF263_19887448_ChIP-Seq_K562_Human1.39559092
37P68_20966046_ChIP-Seq_HELA_Human1.38497927
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.37549339
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37023930
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36123234
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35491452
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33534422
43TCF7_22412390_ChIP-Seq_EML_Mouse1.32025408
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29628410
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.27917616
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.27418747
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.27229471
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27001609
49VDR_21846776_ChIP-Seq_THP-1_Human1.25459938
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.24683550
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24107242
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23165276
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.21877045
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20656239
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20533714
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19409580
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18232034
58CREB1_26743006_Chip-Seq_LNCaP_Human1.16620565
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15552331
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.15321807
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15315470
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14783866
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14470176
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14365809
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14137702
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13615129
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13001281
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12915496
69AHR_22903824_ChIP-Seq_MCF-7_Human1.12781799
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.12691763
71ZNF274_21170338_ChIP-Seq_K562_Hela1.12465996
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11834084
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11582678
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.11292998
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11268890
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10904996
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09498777
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.09191031
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.07774526
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.07509268
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07439956
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.05758489
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05690227
84LXR_22292898_ChIP-Seq_THP-1_Human1.05589395
85BCOR_27268052_Chip-Seq_Bcells_Human1.04344169
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03122254
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03061534
88SA1_27219007_Chip-Seq_Bcells_Human1.02481601
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.02230005
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.01796812
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01312888
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01082897
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00972396
94* OCT4_19829295_ChIP-Seq_ESCs_Human0.99073736
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98467711
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98265709
97VDR_24763502_ChIP-Seq_THP-1_Human0.97942931
98BCL6_27268052_Chip-Seq_Bcells_Human0.97461036
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.96965902
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96906157
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96790861
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96738212
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96692076
104* KLF4_19829295_ChIP-Seq_ESCs_Human0.96400458
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96037520
106JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95185990
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.95009566
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94951598
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94706927
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94704120
111AR_19668381_ChIP-Seq_PC3_Human0.93529434
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.93477295
113AR_25329375_ChIP-Seq_VCAP_Human0.93094261
114CTCF_27219007_Chip-Seq_Bcells_Human0.92909497
115CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92852781
116RXR_22108803_ChIP-Seq_LS180_Human0.92842070
117SMC4_20622854_ChIP-Seq_HELA_Human0.92260372
118SPI1_23127762_ChIP-Seq_K562_Human0.92190924
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.91943934
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91855169
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91365473
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91084846
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90764682
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.90393970
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.88287826
126AR_21572438_ChIP-Seq_LNCaP_Human0.87992714
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87391390
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87058433
129BCAT_22108803_ChIP-Seq_LS180_Human0.86903339
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.86814600
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86602145
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86188714
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85859372
134* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85071810
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.83021990
136CLOCK_20551151_ChIP-Seq_293T_Human0.82933276
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82855245
138GATA1_19941826_ChIP-Seq_K562_Human0.82790646
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82171741
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81919332
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81316923
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.80555294
143* TP63_22573176_ChIP-Seq_HFKS_Human0.80464471
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79774155
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.79204698
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.79204698
147STAT3_23295773_ChIP-Seq_U87_Human0.79046055
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78443240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.86009253
2MP0009780_abnormal_chondrocyte_physiolo3.02718233
3MP0003329_amyloid_beta_deposits2.89526706
4MP0004270_analgesia2.85254524
5MP0003635_abnormal_synaptic_transmissio2.83667339
6MP0005410_abnormal_fertilization2.66172836
7MP0002909_abnormal_adrenal_gland2.65880320
8MP0001984_abnormal_olfaction2.63640591
9MP0009046_muscle_twitch2.46869336
10MP0000013_abnormal_adipose_tissue2.40510237
11MP0004858_abnormal_nervous_system2.32821913
12MP0002063_abnormal_learning/memory/cond2.29611294
13MP0002064_seizures2.26463315
14MP0010234_abnormal_vibrissa_follicle2.21428130
15MP0004510_myositis2.15747837
16MP0008961_abnormal_basal_metabolism2.10585371
17MP0003880_abnormal_central_pattern2.07904700
18MP0009745_abnormal_behavioral_response1.99034358
19MP0002734_abnormal_mechanical_nocicepti1.98350817
20MP0003191_abnormal_cellular_cholesterol1.96241412
21MP0000604_amyloidosis1.91204350
22MP0001968_abnormal_touch/_nociception1.91078975
23MP0003303_peritoneal_inflammation1.89460733
24MP0002572_abnormal_emotion/affect_behav1.86669609
25MP0001501_abnormal_sleep_pattern1.75380256
26MP0002272_abnormal_nervous_system1.72713149
27MP0004233_abnormal_muscle_weight1.68311247
28MP0009840_abnormal_foam_cell1.68083257
29MP0002822_catalepsy1.62518879
30MP0008260_abnormal_autophagy1.62457977
31MP0001440_abnormal_grooming_behavior1.61763006
32MP0008569_lethality_at_weaning1.56861009
33MP0002736_abnormal_nociception_after1.54934821
34MP0001970_abnormal_pain_threshold1.51970307
35MP0002090_abnormal_vision1.51563544
36MP0008874_decreased_physiological_sensi1.48969096
37MP0002733_abnormal_thermal_nociception1.48083142
38MP0004811_abnormal_neuron_physiology1.47994698
39MP0003633_abnormal_nervous_system1.47671836
40MP0003690_abnormal_glial_cell1.46838902
41MP0003183_abnormal_peptide_metabolism1.43992049
42MP0002837_dystrophic_cardiac_calcinosis1.43641824
43MP0004885_abnormal_endolymph1.43023470
44MP0004043_abnormal_pH_regulation1.41695625
45MP0003075_altered_response_to1.41662788
46MP0002735_abnormal_chemical_nociception1.39687613
47MP0003879_abnormal_hair_cell1.37917051
48MP0002877_abnormal_melanocyte_morpholog1.34799573
49MP0001905_abnormal_dopamine_level1.28430270
50MP0005365_abnormal_bile_salt1.28264895
51MP0000003_abnormal_adipose_tissue1.27590438
52MP0005167_abnormal_blood-brain_barrier1.27057091
53MP0004130_abnormal_muscle_cell1.26283210
54MP0002067_abnormal_sensory_capabilities1.26013441
55MP0005464_abnormal_platelet_physiology1.24345044
56MP0005451_abnormal_body_composition1.23888016
57MP0003634_abnormal_glial_cell1.23663634
58MP0000955_abnormal_spinal_cord1.23071693
59MP0001486_abnormal_startle_reflex1.21287906
60MP0003195_calcinosis1.20931610
61MP0005535_abnormal_body_temperature1.19485931
62MP0005058_abnormal_lysosome_morphology1.19224331
63MP0005409_darkened_coat_color1.18344033
64MP0003123_paternal_imprinting1.18162841
65MP0003631_nervous_system_phenotype1.14895506
66MP0010329_abnormal_lipoprotein_level1.13199473
67MP0002184_abnormal_innervation1.13171148
68MP0003436_decreased_susceptibility_to1.12968011
69MP0005670_abnormal_white_adipose1.12415598
70MP0002139_abnormal_hepatobiliary_system1.11925852
71MP0003172_abnormal_lysosome_physiology1.10630776
72MP0005646_abnormal_pituitary_gland1.09014645
73MP0001502_abnormal_circadian_rhythm1.06503915
74MP0002557_abnormal_social/conspecific_i1.04032021
75MP0005623_abnormal_meninges_morphology1.02870633
76MP0002078_abnormal_glucose_homeostasis1.01263263
77MP0005386_behavior/neurological_phenoty1.00753906
78MP0004924_abnormal_behavior1.00753906
79MP0002229_neurodegeneration0.98836210
80MP0002066_abnormal_motor_capabilities/c0.98353353
81MP0002118_abnormal_lipid_homeostasis0.97266128
82MP0003705_abnormal_hypodermis_morpholog0.96918583
83MP0005360_urolithiasis0.96886417
84MP0005187_abnormal_penis_morphology0.95730288
85MP0010386_abnormal_urinary_bladder0.95426601
86MP0000343_altered_response_to0.95320789
87MP0004036_abnormal_muscle_relaxation0.95153884
88MP0000751_myopathy0.94401867
89MP0005423_abnormal_somatic_nervous0.93194685
90MP0004084_abnormal_cardiac_muscle0.92292761
91MP0002882_abnormal_neuron_morphology0.91650153
92MP0003632_abnormal_nervous_system0.87419856
93MP0000920_abnormal_myelination0.87350671
94MP0001944_abnormal_pancreas_morphology0.86609555
95MP0001765_abnormal_ion_homeostasis0.86505552
96MP0002254_reproductive_system_inflammat0.85836621
97MP0006082_CNS_inflammation0.85527716
98MP0000747_muscle_weakness0.84802322
99MP0001299_abnormal_eye_distance/0.83738000
100MP0002693_abnormal_pancreas_physiology0.83030915
101MP0003045_fibrosis0.82244496
102MP0004085_abnormal_heartbeat0.82082570
103MP0003300_gastrointestinal_ulcer0.81979734
104MP0010368_abnormal_lymphatic_system0.81129264
105MP0005448_abnormal_energy_balance0.79866776
106MP0004947_skin_inflammation0.77730648
107MP0003453_abnormal_keratinocyte_physiol0.77227797
108MP0002069_abnormal_eating/drinking_beha0.76891238
109MP0005166_decreased_susceptibility_to0.76765379
110MP0002796_impaired_skin_barrier0.76252660
111MP0001958_emphysema0.74695805
112MP0002998_abnormal_bone_remodeling0.73943936
113MP0005165_increased_susceptibility_to0.73768826
114MP0003283_abnormal_digestive_organ0.73479028
115MP0000778_abnormal_nervous_system0.73442559
116MP0005551_abnormal_eye_electrophysiolog0.73342170
117MP0005375_adipose_tissue_phenotype0.73130115
118MP0005645_abnormal_hypothalamus_physiol0.71895022
119MP0001533_abnormal_skeleton_physiology0.70065338
120MP0003724_increased_susceptibility_to0.68818087
121MP0002419_abnormal_innate_immunity0.66005547
122MP0003566_abnormal_cell_adhesion0.65841824
123MP0004742_abnormal_vestibular_system0.65671923
124MP0008004_abnormal_stomach_pH0.64052397
125MP0001849_ear_inflammation0.63618118
126MP0003122_maternal_imprinting0.60588070
127MP0002089_abnormal_postnatal_growth/wei0.60402012
128MP0000681_abnormal_thyroid_gland0.58955170
129MP0005584_abnormal_enzyme/coenzyme_acti0.58493334
130MP0006276_abnormal_autonomic_nervous0.57886090
131MP0001963_abnormal_hearing_physiology0.56781733
132MP0001851_eye_inflammation0.55550670
133MP0001177_atelectasis0.54501499

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.05041551
2Abnormality of binocular vision (HP:0011514)3.95350210
3Diplopia (HP:0000651)3.95350210
4Myokymia (HP:0002411)3.57871147
5Obstructive sleep apnea (HP:0002870)3.50233336
6Supranuclear gaze palsy (HP:0000605)3.48647401
7Abnormality of the lower motor neuron (HP:0002366)3.45589005
8Abnormality of glycolipid metabolism (HP:0010969)3.20185528
9Abnormality of liposaccharide metabolism (HP:0010968)3.20185528
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.20185528
11Neurofibrillary tangles (HP:0002185)3.17005186
12Action tremor (HP:0002345)3.11091513
13Cerebral inclusion bodies (HP:0100314)3.09692025
14Focal seizures (HP:0007359)3.03244930
15Focal motor seizures (HP:0011153)2.98363116
16Progressive cerebellar ataxia (HP:0002073)2.94981207
17Mutism (HP:0002300)2.80064858
18Ankle clonus (HP:0011448)2.78897826
19Diminished motivation (HP:0000745)2.75521534
20Axonal loss (HP:0003447)2.70653022
21Febrile seizures (HP:0002373)2.69808547
22Increased cerebral lipofuscin (HP:0011813)2.67028257
23Annular pancreas (HP:0001734)2.65414303
24Depression (HP:0000716)2.65370621
25Generalized tonic-clonic seizures (HP:0002069)2.60510302
26Dysmetric saccades (HP:0000641)2.59208953
27Amyloidosis (HP:0011034)2.54054142
28Delusions (HP:0000746)2.51187186
29Systemic lupus erythematosus (HP:0002725)2.49930395
30Epileptic encephalopathy (HP:0200134)2.47096211
31Global brain atrophy (HP:0002283)2.46344003
32Hyperinsulinemic hypoglycemia (HP:0000825)2.46330453
33Ventricular fibrillation (HP:0001663)2.46139561
34Intention tremor (HP:0002080)2.45904612
35Atonic seizures (HP:0010819)2.40280208
36Absence seizures (HP:0002121)2.40025914
37Peripheral hypomyelination (HP:0007182)2.37373667
38Neuronal loss in central nervous system (HP:0002529)2.37061094
39Dementia (HP:0000726)2.36027506
40Postural instability (HP:0002172)2.35830057
41Lower limb amyotrophy (HP:0007210)2.35101472
42Bundle branch block (HP:0011710)2.34807899
43Nuclear cataract (HP:0100018)2.31705415
44Retinal atrophy (HP:0001105)2.31187108
45Exercise-induced myalgia (HP:0003738)2.30970677
46Agitation (HP:0000713)2.30399096
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28557160
48Abnormality of polysaccharide metabolism (HP:0011012)2.28557160
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28393857
50Purpura (HP:0000979)2.28021714
51Torticollis (HP:0000473)2.25354544
52Truncal ataxia (HP:0002078)2.22918517
53Bradykinesia (HP:0002067)2.22579790
54Hand muscle atrophy (HP:0009130)2.22024425
55Akinesia (HP:0002304)2.21053111
56Pheochromocytoma (HP:0002666)2.19878504
57Loss of speech (HP:0002371)2.17978089
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15613851
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14810581
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.12094672
61Absent/shortened dynein arms (HP:0200106)2.12094672
62Distal upper limb amyotrophy (HP:0007149)2.10028304
63Upper limb amyotrophy (HP:0009129)2.10028304
64Dysdiadochokinesis (HP:0002075)2.09920288
65Rapidly progressive (HP:0003678)2.09845292
66Spastic tetraparesis (HP:0001285)2.09785625
67Clonus (HP:0002169)2.09033589
68EEG with generalized epileptiform discharges (HP:0011198)2.08967292
69Hypoglycemic seizures (HP:0002173)2.08943177
70Dialeptic seizures (HP:0011146)2.08235081
71Impaired social interactions (HP:0000735)2.07848059
72Abnormal social behavior (HP:0012433)2.07848059
73Limb dystonia (HP:0002451)2.06751661
74Hypsarrhythmia (HP:0002521)2.06356632
75Insulin-resistant diabetes mellitus (HP:0000831)2.06038864
76Gout (HP:0001997)2.05753210
77Dysostosis multiplex (HP:0000943)2.04790114
78Epileptiform EEG discharges (HP:0011182)2.03857751
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.02752781
80Genetic anticipation (HP:0003743)2.02678853
81Lower limb muscle weakness (HP:0007340)2.01797752
82Hypercortisolism (HP:0001578)2.00515453
83Ketoacidosis (HP:0001993)2.00393366
84Polyphagia (HP:0002591)2.00147231
85Postural tremor (HP:0002174)1.99598809
86Slow saccadic eye movements (HP:0000514)1.99249252
87Termporal pattern (HP:0011008)1.99246025
88Insidious onset (HP:0003587)1.99246025
89Dysmetria (HP:0001310)1.99178596
90Abnormal eating behavior (HP:0100738)1.98068304
91Infertility (HP:0000789)1.97667986
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96862458
93Abnormality of ocular smooth pursuit (HP:0000617)1.96458644
94Chronic bronchitis (HP:0004469)1.95180888
95Insomnia (HP:0100785)1.94612436
96Anxiety (HP:0000739)1.94160362
97Rigidity (HP:0002063)1.94046690
98Distal lower limb amyotrophy (HP:0008944)1.93399291
99Large for gestational age (HP:0001520)1.93145784
100Cerebral hypomyelination (HP:0006808)1.93100687
101Tetraplegia (HP:0002445)1.92539437
102Hyperglycemia (HP:0003074)1.92197372
103Papilledema (HP:0001085)1.90854490
104Mucopolysacchariduria (HP:0008155)1.90254051
105Urinary glycosaminoglycan excretion (HP:0003541)1.90254051
106Hemiplegia (HP:0002301)1.88348524
107Gait ataxia (HP:0002066)1.87716905
108Male infertility (HP:0003251)1.85702463
109Eczematoid dermatitis (HP:0000976)1.85284974
110Hypoglycemic coma (HP:0001325)1.85225282
111Poor eye contact (HP:0000817)1.85045577
112Sleep apnea (HP:0010535)1.84804619
113Abnormality of the Achilles tendon (HP:0005109)1.84606023
114Impaired smooth pursuit (HP:0007772)1.84492461
115Morphological abnormality of the pyramidal tract (HP:0002062)1.84242813
116Xanthomatosis (HP:0000991)1.83274564
117Distal lower limb muscle weakness (HP:0009053)1.82827867
118Abnormality of saccadic eye movements (HP:0000570)1.82378133
119Achilles tendon contracture (HP:0001771)1.82074787
120Amyotrophic lateral sclerosis (HP:0007354)1.82021313
121Megalencephaly (HP:0001355)1.82018803
122Scanning speech (HP:0002168)1.81637068
123Focal dystonia (HP:0004373)1.81548507
124Urinary urgency (HP:0000012)1.80823493
125Complement deficiency (HP:0004431)1.79836379
126Status epilepticus (HP:0002133)1.79434156
127Asymmetric septal hypertrophy (HP:0001670)1.78876882
128Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78083802
129Abnormality of macrophages (HP:0004311)1.77738757
130Impaired vibration sensation in the lower limbs (HP:0002166)1.77734656
131Neuroendocrine neoplasm (HP:0100634)1.76956859
132Cholecystitis (HP:0001082)1.76517122
133Abnormal gallbladder physiology (HP:0012438)1.76517122
134Memory impairment (HP:0002354)1.75818012
135Craniofacial dystonia (HP:0012179)1.75407009
136Hemiparesis (HP:0001269)1.74177848
137Urinary bladder sphincter dysfunction (HP:0002839)1.73504306
138Growth hormone excess (HP:0000845)1.73358892
139Apathy (HP:0000741)1.72806530
140Cerebral aneurysm (HP:0004944)1.72532229
141Abnormality of the periventricular white matter (HP:0002518)1.72271706
142Ocular albinism (HP:0001107)1.71102822
143Increased CSF protein (HP:0002922)1.69924294
144Foot dorsiflexor weakness (HP:0009027)1.68865189
145Ketosis (HP:0001946)1.68702414
146Spastic gait (HP:0002064)1.68452012
147Distal sensory impairment (HP:0002936)1.67449826
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66911956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.61754260
2MAP3K92.83302343
3PDK42.76172131
4PDK32.76172131
5TRIB32.72517985
6MAP3K22.61876499
7PRPF4B2.54557900
8NTRK32.49985259
9PDK22.49071601
10KSR22.32046724
11MAP3K112.24116085
12MAP3K42.09275292
13CAMKK11.88520370
14EPHA41.84523394
15NTRK11.82301412
16MINK11.80148858
17PAK61.79579724
18DAPK21.77331730
19MARK11.70272099
20INSRR1.57847422
21FGFR21.57523424
22RIPK11.52150572
23MAP2K41.51887924
24CAMKK21.50731681
25NTRK21.47450048
26TYRO31.45307806
27LMTK21.43004751
28TESK11.41017996
29FRK1.39141170
30TAOK21.37306355
31TAOK11.36032989
32RET1.34879380
33LIMK11.33308956
34MAP3K11.31822994
35MARK21.31144355
36PTK2B1.29880284
37PAK31.28998240
38STK381.21241143
39PRKCH1.18833905
40PHKG11.18294451
41PHKG21.18294451
42MAP2K71.13382457
43CDK51.12125001
44SIK21.08079318
45IRAK31.07620298
46TNK21.07099699
47TESK21.06687142
48FER1.04923347
49PDK11.01966749
50CAMK11.01514181
51GRK51.00474047
52ERN10.98860155
53PDPK10.98319772
54WNK40.96003187
55CDK190.94249170
56PIM20.93973363
57PRKCG0.91852461
58SGK4940.91761631
59SGK2230.91761631
60PDGFRA0.90368713
61MOS0.90368403
62PINK10.90106431
63RIPK40.89916942
64SCYL20.89617880
65FES0.88404965
66NEK10.88190103
67ALK0.87227877
68ARAF0.86845474
69SGK30.86339907
70BRAF0.86317000
71PRKD20.84597747
72PTK20.84121941
73MAP2K10.83326598
74PTK60.82718975
75DAPK30.81266851
76CAMK2G0.80715415
77CDK180.80280135
78PLK20.79914159
79CDK11A0.79898341
80CAMK1G0.78699382
81MAP3K30.78418802
82ICK0.77516980
83ABL20.76935119
84MAP2K30.71767536
85AKT30.68168272
86EPHA30.68081999
87WNK10.66132138
88PKN20.63499235
89PRKG20.62273438
90STK110.60981414
91SGK20.60182387
92EPHB10.59286574
93DDR20.58425498
94BLK0.58358005
95MAP3K130.57806842
96UHMK10.57423301
97MAPK150.57356336
98IRAK20.56058837
99BMX0.54998131
100RPS6KA20.54666035
101LATS20.54609724
102CAMK2A0.52852240
103MAP2K60.52172105
104FYN0.51952907
105TAOK30.50704774
106TBK10.50441051
107CAMK40.50112864
108RAF10.49457233
109ROCK20.48918813
110PRKCZ0.48340061
111BMPR20.48083944
112FGFR40.47428906
113PKN10.46016667
114KSR10.45880001
115CDK140.45310098
116MAPK120.44748003
117PRKAA10.44409842
118DMPK0.43628618
119CAMK2D0.43076170
120DYRK1B0.42953804
121PRKCE0.42570565
122SIK10.42393428
123JAK10.40971366
124CAMK2B0.40857933
125MAPK100.40706936
126PRKACG0.40224842
127CDC42BPA0.39975410
128FGFR30.39584963
129MST1R0.38562298
130DAPK10.38042256
131CAMK1D0.37588932
132PNCK0.37417791
133RPS6KA30.37338948
134PDGFRB0.36484393
135CDK150.36277776
136PRKD10.36197742
137JAK20.35443709
138HIPK20.35008073

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.79678731
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23916375
3Olfactory transduction_Homo sapiens_hsa047402.10975343
4Nitrogen metabolism_Homo sapiens_hsa009101.99580200
5Insulin secretion_Homo sapiens_hsa049111.93348471
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83563232
7GABAergic synapse_Homo sapiens_hsa047271.78843181
8Long-term potentiation_Homo sapiens_hsa047201.73584327
9Circadian entrainment_Homo sapiens_hsa047131.71913369
10Collecting duct acid secretion_Homo sapiens_hsa049661.71230049
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66699447
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.62275927
13Amphetamine addiction_Homo sapiens_hsa050311.59474734
14Nicotine addiction_Homo sapiens_hsa050331.54940732
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51027155
16Type II diabetes mellitus_Homo sapiens_hsa049301.50451152
17Glutamatergic synapse_Homo sapiens_hsa047241.50029110
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45952798
19Salivary secretion_Homo sapiens_hsa049701.40485085
20Vibrio cholerae infection_Homo sapiens_hsa051101.39223574
21Dopaminergic synapse_Homo sapiens_hsa047281.36359044
22Gastric acid secretion_Homo sapiens_hsa049711.35594749
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35404966
24Morphine addiction_Homo sapiens_hsa050321.35109330
25Cocaine addiction_Homo sapiens_hsa050301.34213473
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34161871
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.30331318
28Renin secretion_Homo sapiens_hsa049241.27671100
29Other glycan degradation_Homo sapiens_hsa005111.23251353
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21059756
31Cholinergic synapse_Homo sapiens_hsa047251.19290268
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15989585
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14810639
34Estrogen signaling pathway_Homo sapiens_hsa049151.12706911
35Vitamin B6 metabolism_Homo sapiens_hsa007501.12553405
36Bile secretion_Homo sapiens_hsa049761.12157711
37Long-term depression_Homo sapiens_hsa047301.07375660
38Pancreatic secretion_Homo sapiens_hsa049721.04771899
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02494251
40GnRH signaling pathway_Homo sapiens_hsa049121.00951119
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.00494364
42Taste transduction_Homo sapiens_hsa047420.99122985
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99031941
44Arginine biosynthesis_Homo sapiens_hsa002200.99028175
45Gap junction_Homo sapiens_hsa045400.95938787
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95463644
47Oxytocin signaling pathway_Homo sapiens_hsa049210.93403912
48Glucagon signaling pathway_Homo sapiens_hsa049220.93022665
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92979309
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91017945
51Lysosome_Homo sapiens_hsa041420.86900113
52Thyroid hormone synthesis_Homo sapiens_hsa049180.84906381
53mTOR signaling pathway_Homo sapiens_hsa041500.84689642
54Osteoclast differentiation_Homo sapiens_hsa043800.84177090
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83339121
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81888259
57Calcium signaling pathway_Homo sapiens_hsa040200.81556787
58Salmonella infection_Homo sapiens_hsa051320.80906094
59Glioma_Homo sapiens_hsa052140.80029958
60cAMP signaling pathway_Homo sapiens_hsa040240.79684910
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77963839
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.77642666
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75851193
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75847203
65Tuberculosis_Homo sapiens_hsa051520.75499208
66Serotonergic synapse_Homo sapiens_hsa047260.73851928
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73095671
68Insulin resistance_Homo sapiens_hsa049310.72820402
69Butanoate metabolism_Homo sapiens_hsa006500.71219598
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.70472797
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70386639
72VEGF signaling pathway_Homo sapiens_hsa043700.69873919
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.69244993
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68964693
75Insulin signaling pathway_Homo sapiens_hsa049100.67696277
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67280844
77Inositol phosphate metabolism_Homo sapiens_hsa005620.64194382
78Melanogenesis_Homo sapiens_hsa049160.64130954
79Circadian rhythm_Homo sapiens_hsa047100.63663814
80ErbB signaling pathway_Homo sapiens_hsa040120.63151447
81Endocytosis_Homo sapiens_hsa041440.62977708
82Rap1 signaling pathway_Homo sapiens_hsa040150.62297559
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61981410
84Pertussis_Homo sapiens_hsa051330.60608300
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.59801981
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.59787919
87Fatty acid metabolism_Homo sapiens_hsa012120.59426712
88Glycerolipid metabolism_Homo sapiens_hsa005610.59259634
89Amoebiasis_Homo sapiens_hsa051460.58403635
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58042242
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.57625145
92Prion diseases_Homo sapiens_hsa050200.57289375
93Sulfur metabolism_Homo sapiens_hsa009200.55926235
94PPAR signaling pathway_Homo sapiens_hsa033200.55568526
95Histidine metabolism_Homo sapiens_hsa003400.55497518
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.55489022
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55168451
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53882595
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53791712
100Phenylalanine metabolism_Homo sapiens_hsa003600.53056676
101Fatty acid biosynthesis_Homo sapiens_hsa000610.52618199
102Rheumatoid arthritis_Homo sapiens_hsa053230.52295241
103Chemokine signaling pathway_Homo sapiens_hsa040620.52153327
104* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51624436
105Complement and coagulation cascades_Homo sapiens_hsa046100.51528524
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.50852853
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49707254
108Dilated cardiomyopathy_Homo sapiens_hsa054140.49695232
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49612873
110Axon guidance_Homo sapiens_hsa043600.49485399
111Ras signaling pathway_Homo sapiens_hsa040140.49441406
112Fat digestion and absorption_Homo sapiens_hsa049750.48396535
113Arginine and proline metabolism_Homo sapiens_hsa003300.48112153
114Phagosome_Homo sapiens_hsa041450.47947065
115Staphylococcus aureus infection_Homo sapiens_hsa051500.47638750
116Pyruvate metabolism_Homo sapiens_hsa006200.46526123
117Renal cell carcinoma_Homo sapiens_hsa052110.45823837
118Mineral absorption_Homo sapiens_hsa049780.45776051
119Ovarian steroidogenesis_Homo sapiens_hsa049130.45630923
120Choline metabolism in cancer_Homo sapiens_hsa052310.44976903
121Fatty acid degradation_Homo sapiens_hsa000710.44506649
122B cell receptor signaling pathway_Homo sapiens_hsa046620.44454176
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.43626258
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43466832
125Platelet activation_Homo sapiens_hsa046110.43240166
126MAPK signaling pathway_Homo sapiens_hsa040100.42493564
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42056362
128AMPK signaling pathway_Homo sapiens_hsa041520.41987385
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41832309
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.39150200

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