TOM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)7.26939433
2protein insertion into membrane (GO:0051205)5.51203478
3response to peptidoglycan (GO:0032494)4.73777679
4sarcomere organization (GO:0045214)4.64567099
5tricarboxylic acid cycle (GO:0006099)4.57546937
6negative regulation of interleukin-12 production (GO:0032695)4.47316545
7plasma membrane repair (GO:0001778)4.46698577
8neutrophil activation involved in immune response (GO:0002283)4.20887578
9sensory perception of chemical stimulus (GO:0007606)4.17131390
10NADH metabolic process (GO:0006734)4.14185553
11macrophage activation involved in immune response (GO:0002281)4.01208473
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00498114
13negative regulation of cell killing (GO:0031342)4.00498114
14bundle of His cell to Purkinje myocyte communication (GO:0086069)3.88858276
15actin-myosin filament sliding (GO:0033275)3.85277406
16muscle filament sliding (GO:0030049)3.85277406
17modulation by symbiont of host immune response (GO:0052553)3.83398428
18positive regulation by symbiont of host defense response (GO:0052509)3.83398428
19modulation by symbiont of host defense response (GO:0052031)3.83398428
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83398428
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83398428
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.83398428
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.69528620
24positive regulation of gamma-delta T cell activation (GO:0046645)3.68261414
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61309347
26detection of other organism (GO:0098543)3.55795235
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.53281428
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.45170982
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.41137121
30regulation of skeletal muscle contraction (GO:0014819)3.40777019
312-oxoglutarate metabolic process (GO:0006103)3.40455350
32detection of molecule of bacterial origin (GO:0032490)3.37712988
33creatine metabolic process (GO:0006600)3.37282339
34detection of bacterium (GO:0016045)3.36889463
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.32685085
36myofibril assembly (GO:0030239)3.31675216
37ventricular cardiac muscle cell action potential (GO:0086005)3.30427290
38germinal center formation (GO:0002467)3.28120171
39negative regulation of erythrocyte differentiation (GO:0045647)3.26814138
40glycosphingolipid catabolic process (GO:0046479)3.26425625
41immunoglobulin mediated immune response (GO:0016064)3.26046196
42cardiac muscle contraction (GO:0060048)3.25659822
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.25014881
44fatty acid beta-oxidation (GO:0006635)3.24620164
45COPI coating of Golgi vesicle (GO:0048205)3.22570252
46Golgi transport vesicle coating (GO:0048200)3.22570252
47detection of external biotic stimulus (GO:0098581)3.21441050
48response to muramyl dipeptide (GO:0032495)3.21189979
49NIK/NF-kappaB signaling (GO:0038061)3.20851653
50cellular response to thyroid hormone stimulus (GO:0097067)3.20103919
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19499798
52carnitine shuttle (GO:0006853)3.17536809
53negative regulation of cytokine production involved in immune response (GO:0002719)3.16473451
54aspartate family amino acid catabolic process (GO:0009068)3.14765195
55actin-mediated cell contraction (GO:0070252)3.14497578
56oxaloacetate metabolic process (GO:0006107)3.13299650
57glycogen catabolic process (GO:0005980)3.12635920
58biotin metabolic process (GO:0006768)3.09870757
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09092855
60heart contraction (GO:0060047)3.08874426
61heart process (GO:0003015)3.08874426
62tricarboxylic acid metabolic process (GO:0072350)3.08247674
63positive regulation of triglyceride biosynthetic process (GO:0010867)3.08242539
64regulation of T-helper 2 cell differentiation (GO:0045628)3.05514044
65fatty acid transmembrane transport (GO:1902001)3.05297018
66granulocyte activation (GO:0036230)3.04681458
67ethanol oxidation (GO:0006069)3.04353458
68regulation of sequestering of triglyceride (GO:0010889)3.03437679
69sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03363402
70cardiac myofibril assembly (GO:0055003)3.02011001
71cellular extravasation (GO:0045123)3.00382188
72sulfur amino acid catabolic process (GO:0000098)3.00321475
73regulation of mast cell degranulation (GO:0043304)2.99503238
74regulation of mononuclear cell migration (GO:0071675)2.98096428
754-hydroxyproline metabolic process (GO:0019471)2.97516371
76short-chain fatty acid metabolic process (GO:0046459)2.97180803
77T-helper 1 type immune response (GO:0042088)2.96580038
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96023193
79antigen processing and presentation of endogenous antigen (GO:0019883)2.94616474
80amino sugar catabolic process (GO:0046348)2.94362545
81glycolipid catabolic process (GO:0019377)2.94289241
82regulation of interferon-beta biosynthetic process (GO:0045357)2.93123705
83oligosaccharide catabolic process (GO:0009313)2.92150709
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91988114
85low-density lipoprotein particle clearance (GO:0034383)2.90625234
86macrophage activation (GO:0042116)2.90371650
87lipid oxidation (GO:0034440)2.90004760
88regulation of vitamin D biosynthetic process (GO:0060556)2.89890305
89fatty acid oxidation (GO:0019395)2.89692821
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87808733
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87326626
92glucan catabolic process (GO:0009251)2.87112452
93carnitine transmembrane transport (GO:1902603)2.86981379
94detection of biotic stimulus (GO:0009595)2.86961256
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85973895
96positive regulation of chemokine biosynthetic process (GO:0045080)2.85271587
97type I interferon signaling pathway (GO:0060337)2.84325902
98cellular response to type I interferon (GO:0071357)2.84325902
99fatty acid catabolic process (GO:0009062)2.82701445
100positive regulation of cellular amide metabolic process (GO:0034250)2.82477744
101regulation of chromatin binding (GO:0035561)2.82344289
102response to type I interferon (GO:0034340)2.80911776
103regulation of gamma-delta T cell activation (GO:0046643)2.80448228
104lysine metabolic process (GO:0006553)2.79254370
105lysine catabolic process (GO:0006554)2.79254370
106neutrophil activation (GO:0042119)2.79231799
107regulation of leukocyte degranulation (GO:0043300)2.78071374
108defense response to protozoan (GO:0042832)2.78035371
109cell communication involved in cardiac conduction (GO:0086065)2.78033326
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77458883
111regulation of podosome assembly (GO:0071801)2.77242207
112interferon-gamma-mediated signaling pathway (GO:0060333)2.77095285
113branched-chain amino acid catabolic process (GO:0009083)2.76812425
114myeloid dendritic cell differentiation (GO:0043011)2.76507680
115myeloid cell activation involved in immune response (GO:0002275)2.76190230
116amino-acid betaine transport (GO:0015838)2.76127203
117carnitine transport (GO:0015879)2.76127203
118barbed-end actin filament capping (GO:0051016)2.75887277
119acetyl-CoA metabolic process (GO:0006084)2.73467170
120regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73420424
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72724821
122ADP metabolic process (GO:0046031)2.72681351
123positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71983095
124response to protozoan (GO:0001562)2.69657190
125regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69016963
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68872758
127cellular polysaccharide catabolic process (GO:0044247)2.68445919
128regulation of mast cell activation involved in immune response (GO:0033006)2.67954253
129striated muscle contraction (GO:0006941)2.66348493
130negative regulation of myeloid cell apoptotic process (GO:0033033)2.66011812
131ethanol metabolic process (GO:0006067)2.65970004
132mannose metabolic process (GO:0006013)2.65959188
133regulation of cilium movement (GO:0003352)2.65475886
134actomyosin structure organization (GO:0031032)2.65085172
135regulation of cytokine secretion involved in immune response (GO:0002739)2.62835801
136leukocyte aggregation (GO:0070486)2.62798040
137regulation of chemokine biosynthetic process (GO:0045073)2.61921805
138response to thyroid hormone (GO:0097066)2.61111027
139oxidative phosphorylation (GO:0006119)2.60536652
140protein localization to endosome (GO:0036010)2.60293176
141positive regulation of type 2 immune response (GO:0002830)2.59549858
142regulation of actin filament-based movement (GO:1903115)2.59289577
143regulation of heart rate by cardiac conduction (GO:0086091)2.59262492
144gluconeogenesis (GO:0006094)2.57893324
145positive regulation of triglyceride metabolic process (GO:0090208)2.57636002
146polysaccharide catabolic process (GO:0000272)2.57130483
147CDP-diacylglycerol metabolic process (GO:0046341)2.57104157
148positive regulation of antigen processing and presentation (GO:0002579)2.56723181
149regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.56445011
150regulation of fatty acid oxidation (GO:0046320)2.56409237
151regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55928790
152regulation of relaxation of muscle (GO:1901077)2.55767058
153regulation of antigen processing and presentation (GO:0002577)2.54851567
154N-acetylneuraminate metabolic process (GO:0006054)2.54702353
155negative regulation of innate immune response (GO:0045824)2.54473417
156respiratory burst (GO:0045730)2.54000869
157positive regulation of cholesterol efflux (GO:0010875)2.53479714
158negative regulation of production of molecular mediator of immune response (GO:0002701)2.52044548
159monocarboxylic acid catabolic process (GO:0072329)2.51951402
160ceramide catabolic process (GO:0046514)2.51891594
161monosaccharide biosynthetic process (GO:0046364)2.51652525
162negative regulation of interleukin-6 production (GO:0032715)2.51312610
163regulation of cholesterol metabolic process (GO:0090181)2.50102882
164valine metabolic process (GO:0006573)2.49042122
165regulation of macrophage chemotaxis (GO:0010758)2.49011603
166activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48778673
167branched-chain amino acid metabolic process (GO:0009081)2.48739849
168protein localization to cilium (GO:0061512)2.48395359
169cardiac muscle cell development (GO:0055013)2.48223836
170regulation of type 2 immune response (GO:0002828)2.47818529
171response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47648992
172response to host immune response (GO:0052572)2.47648992
173hexose biosynthetic process (GO:0019319)2.46829361
174pinocytosis (GO:0006907)2.45983885
175carnitine metabolic process (GO:0009437)2.45581368
176acyl-CoA biosynthetic process (GO:0071616)2.44795104
177thioester biosynthetic process (GO:0035384)2.44795104
178regulation of cell communication by electrical coupling (GO:0010649)2.44766542
179myeloid dendritic cell activation (GO:0001773)2.44130600
180regulation of T cell tolerance induction (GO:0002664)2.43914826
181regulation of membrane protein ectodomain proteolysis (GO:0051043)2.43795836
182regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.43489138
183regulation of tolerance induction (GO:0002643)2.43107976
184regulation of vitamin metabolic process (GO:0030656)2.43104241
185negative regulation of leukocyte mediated immunity (GO:0002704)2.42908073
186glycogen biosynthetic process (GO:0005978)2.42019839
187glucan biosynthetic process (GO:0009250)2.42019839
188regulation of cholesterol storage (GO:0010885)2.41260585
189CDP-diacylglycerol biosynthetic process (GO:0016024)2.41244940
190negative regulation of lymphocyte mediated immunity (GO:0002707)2.41008481
191cardiac muscle cell action potential involved in contraction (GO:0086002)2.40013511
192regulation of acyl-CoA biosynthetic process (GO:0050812)2.39711855
193regulation of coenzyme metabolic process (GO:0051196)2.39386144
194regulation of cofactor metabolic process (GO:0051193)2.39386144
195positive regulation of mast cell activation (GO:0033005)2.38077273
196negative regulation of tumor necrosis factor production (GO:0032720)2.38023999
197negative regulation of toll-like receptor signaling pathway (GO:0034122)2.37401959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27443881
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.92455746
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67970882
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.65081716
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.20032534
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.99195027
7ZNF263_19887448_ChIP-Seq_K562_Human2.82303478
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79540858
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76804290
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.75977961
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.72313056
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46165587
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44604277
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.43391626
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.42343050
16VDR_24763502_ChIP-Seq_THP-1_Human2.23178346
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22378341
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.17777961
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14906831
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07503764
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06040032
22LXR_22292898_ChIP-Seq_THP-1_Human2.03509184
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01814550
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99316782
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98613337
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98523981
27SPI1_23127762_ChIP-Seq_K562_Human1.91007374
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.82442517
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81865756
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.81746274
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.81746274
32BCOR_27268052_Chip-Seq_Bcells_Human1.73112301
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69308413
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.68043118
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66340375
36KDM2B_26808549_Chip-Seq_DND41_Human1.66334464
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.65210634
38VDR_24787735_ChIP-Seq_THP-1_Human1.63598619
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62747343
40MAF_26560356_Chip-Seq_TH1_Human1.61346007
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61077405
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.59990069
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59290267
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57887212
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.57285438
46CLOCK_20551151_ChIP-Seq_293T_Human1.56184936
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54543608
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54498225
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54051115
50SPI1_23547873_ChIP-Seq_NB4_Human1.51874680
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.51665043
52RACK7_27058665_Chip-Seq_MCF-7_Human1.50267250
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.49922618
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49223344
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47013131
56RUNX_20019798_ChIP-Seq_JUKART_Human1.46065408
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44750045
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.44242205
59ATF3_27146783_Chip-Seq_COLON_Human1.42388108
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.41241988
61P68_20966046_ChIP-Seq_HELA_Human1.40034620
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39526661
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39405508
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39030561
65UTX_26944678_Chip-Seq_JUKART_Human1.37338299
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.36583537
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36049734
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.35957506
69BCL6_27268052_Chip-Seq_Bcells_Human1.34043406
70SCL_19346495_ChIP-Seq_HPC-7_Human1.34014292
71GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.33581230
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32886163
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31327431
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29984087
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28210408
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28198546
77PHF8_20622854_ChIP-Seq_HELA_Human1.27289507
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26711473
79MAF_26560356_Chip-Seq_TH2_Human1.26463720
80MYC_22102868_ChIP-Seq_BL_Human1.26170286
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.25649966
82E2F1_20622854_ChIP-Seq_HELA_Human1.25091858
83GATA1_19941826_ChIP-Seq_K562_Human1.23250912
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22273153
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22211573
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21084627
87CTCF_20526341_ChIP-Seq_ESCs_Human1.21000782
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.20330014
89TP63_22573176_ChIP-Seq_HFKS_Human1.20067746
90KDM2B_26808549_Chip-Seq_K562_Human1.19900333
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19216424
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18738777
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18554426
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18195605
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18081524
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17659249
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16819963
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15096148
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14384750
100OCT4_20526341_ChIP-Seq_ESCs_Human1.14081269
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13918648
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13692603
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.13250922
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12572967
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11556379
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10704033
107P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09407599
108PU_27001747_Chip-Seq_BMDM_Mouse1.09081141
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08926869
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08288024
111FOXH1_21741376_ChIP-Seq_ESCs_Human1.07553545
112EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07425850
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06128749
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06036581
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05816003
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04898725
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04866695
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04637562
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03451934
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03446307
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.02743609
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02436274
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02309771
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01965500
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01842680
126* TFEB_21752829_ChIP-Seq_HELA_Human1.01722543
127TAF2_19829295_ChIP-Seq_ESCs_Human1.01663139
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00671782
129* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00383260
130DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00317788
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00229721
132SMC4_20622854_ChIP-Seq_HELA_Human0.99753301
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.99702904
134* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99603703
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99310292
136CTCF_21964334_Chip-Seq_Bcells_Human0.99306243
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98884339
138BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98686989
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98256858
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.97571195
141VDR_21846776_ChIP-Seq_THP-1_Human0.96913771
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96310822
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96031729
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95494521
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.94629376
146SPI1_20517297_ChIP-Seq_HL60_Human0.94306132
147SA1_27219007_Chip-Seq_Bcells_Human0.94201048
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93722447
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93353199
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92419280
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91772031
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91554512
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90272854
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90040802
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89763096
156KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89687269
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.89479159
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.88555204
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.86313691
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84985116
161* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84344206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.02109931
2MP0003806_abnormal_nucleotide_metabolis4.33246970
3MP0003646_muscle_fatigue4.04079550
4MP0003303_peritoneal_inflammation4.02003808
5MP0005058_abnormal_lysosome_morphology3.95864645
6MP0002837_dystrophic_cardiac_calcinosis3.91571701
7MP0003724_increased_susceptibility_to3.27437218
8MP0000751_myopathy3.11423284
9MP0009840_abnormal_foam_cell3.06573020
10MP0004084_abnormal_cardiac_muscle2.99925476
11MP0000749_muscle_degeneration2.98027321
12MP0002148_abnormal_hypersensitivity_rea2.66880398
13MP0009785_altered_susceptibility_to2.65796685
14MP0002419_abnormal_innate_immunity2.64398733
15MP0004036_abnormal_muscle_relaxation2.59953762
16MP0001835_abnormal_antigen_presentation2.39404656
17MP0003300_gastrointestinal_ulcer2.37248594
18MP0005025_abnormal_response_to2.33993271
19MP0005000_abnormal_immune_tolerance2.30379974
20MP0000750_abnormal_muscle_regeneration2.28169015
21MP0005330_cardiomyopathy2.22875550
22MP0005387_immune_system_phenotype2.21964868
23MP0001790_abnormal_immune_system2.21964868
24MP0004087_abnormal_muscle_fiber2.16725069
25MP0001533_abnormal_skeleton_physiology2.16394941
26MP0004215_abnormal_myocardial_fiber2.16092453
27MP0002269_muscular_atrophy2.10217437
28MP0005670_abnormal_white_adipose2.07633696
29MP0000747_muscle_weakness2.01697314
30MP0005671_abnormal_response_to1.99124865
31MP0000685_abnormal_immune_system1.95743629
32MP0004130_abnormal_muscle_cell1.94531644
33MP0009278_abnormal_bone_marrow1.90808925
34MP0009764_decreased_sensitivity_to1.88704539
35MP0002452_abnormal_antigen_presenting1.85914495
36MP0003172_abnormal_lysosome_physiology1.85327452
37MP0002723_abnormal_immune_serum1.84930754
38MP0005083_abnormal_biliary_tract1.83444000
39MP0003195_calcinosis1.83388062
40MP0004947_skin_inflammation1.78447593
41MP0001800_abnormal_humoral_immune1.77867199
42MP0002998_abnormal_bone_remodeling1.76214701
43MP0008260_abnormal_autophagy1.73777830
44MP0002972_abnormal_cardiac_muscle1.71393934
45MP0000343_altered_response_to1.70466945
46MP0006036_abnormal_mitochondrial_physio1.70217230
47MP0003705_abnormal_hypodermis_morpholog1.68653303
48MP0002106_abnormal_muscle_physiology1.65520303
49MP0005365_abnormal_bile_salt1.62420012
50MP0002420_abnormal_adaptive_immunity1.61667154
51MP0001819_abnormal_immune_cell1.61000510
52MP0001845_abnormal_inflammatory_respons1.55136026
53MP0005464_abnormal_platelet_physiology1.54886929
54MP0010155_abnormal_intestine_physiology1.54869545
55MP0008469_abnormal_protein_level1.51268854
56MP0001853_heart_inflammation1.50813964
57MP0003186_abnormal_redox_activity1.49376561
58MP0002405_respiratory_system_inflammati1.43792998
59MP0005620_abnormal_muscle_contractility1.43755721
60MP0010630_abnormal_cardiac_muscle1.42563855
61MP0005166_decreased_susceptibility_to1.42559150
62MP0004858_abnormal_nervous_system1.42249264
63MP0003453_abnormal_keratinocyte_physiol1.41463029
64MP0000759_abnormal_skeletal_muscle1.41416029
65MP0005167_abnormal_blood-brain_barrier1.41277054
66MP0008004_abnormal_stomach_pH1.41128771
67MP0003566_abnormal_cell_adhesion1.41054570
68MP0000858_altered_metastatic_potential1.38540828
69MP0008775_abnormal_heart_ventricle1.37405670
70MP0005319_abnormal_enzyme/_coenzyme1.37186857
71MP0001542_abnormal_bone_strength1.36312616
72MP0005397_hematopoietic_system_phenotyp1.35704063
73MP0001545_abnormal_hematopoietic_system1.35704063
74MP0002254_reproductive_system_inflammat1.32428711
75MP0003191_abnormal_cellular_cholesterol1.30675288
76MP0001544_abnormal_cardiovascular_syste1.30619822
77MP0005385_cardiovascular_system_phenoty1.30619822
78MP0005369_muscle_phenotype1.29575213
79MP0002139_abnormal_hepatobiliary_system1.29467300
80MP0003448_altered_tumor_morphology1.27947202
81MP0004233_abnormal_muscle_weight1.27350881
82MP0009333_abnormal_splenocyte_physiolog1.26698721
83MP0005666_abnormal_adipose_tissue1.26024557
84MP0005332_abnormal_amino_acid1.25506857
85MP0008875_abnormal_xenobiotic_pharmacok1.23133558
86MP0005410_abnormal_fertilization1.22791577
87MP0005375_adipose_tissue_phenotype1.21479154
88MP0005310_abnormal_salivary_gland1.21377142
89MP0006054_spinal_hemorrhage1.21276202
90MP0004145_abnormal_muscle_electrophysio1.18093993
91MP0005165_increased_susceptibility_to1.16992866
92MP0005584_abnormal_enzyme/coenzyme_acti1.16916418
93MP0003183_abnormal_peptide_metabolism1.15394181
94MP0004484_altered_response_of1.14454353
95MP0000003_abnormal_adipose_tissue1.14156227
96MP0005275_abnormal_skin_tensile1.13785264
97MP0003656_abnormal_erythrocyte_physiolo1.12997756
98MP0009643_abnormal_urine_homeostasis1.12964432
99MP0004510_myositis1.12081824
100MP0008438_abnormal_cutaneous_collagen1.11797289
101MP0002909_abnormal_adrenal_gland1.10215008
102MP0005164_abnormal_response_to1.09078606
103MP0000716_abnormal_immune_system1.08631492
104MP0003279_aneurysm1.06837076
105MP0004043_abnormal_pH_regulation1.04592491
106MP0005085_abnormal_gallbladder_physiolo1.04380125
107MP0005451_abnormal_body_composition1.03803668
108MP0000604_amyloidosis1.03782963
109MP0002118_abnormal_lipid_homeostasis1.03163376
110MP0003252_abnormal_bile_duct1.01668929
111MP0005390_skeleton_phenotype1.01175365
112MP0003137_abnormal_impulse_conducting1.00967194
113MP0005360_urolithiasis1.00616892
114MP0002332_abnormal_exercise_endurance0.99814813
115MP0004185_abnormal_adipocyte_glucose0.99012097
116MP0003221_abnormal_cardiomyocyte_apopto0.98061303
117MP0008789_abnormal_olfactory_epithelium0.95337560
118MP0003091_abnormal_cell_migration0.95001533
119MP0000920_abnormal_myelination0.94464188
120MP0004883_abnormal_blood_vessel0.93630393
121MP0010329_abnormal_lipoprotein_level0.92825449
122MP0006138_congestive_heart_failure0.89004235
123MP0001666_abnormal_nutrient_absorption0.88792644
124MP0002933_joint_inflammation0.88775653
125MP0002877_abnormal_melanocyte_morpholog0.87241920
126MP0000465_gastrointestinal_hemorrhage0.86558576
127MP0001851_eye_inflammation0.86294892
128MP0009763_increased_sensitivity_to0.86004728
129MP0002398_abnormal_bone_marrow0.85585133
130MP0003075_altered_response_to0.85390145
131MP0006035_abnormal_mitochondrial_morpho0.83518638
132MP0003634_abnormal_glial_cell0.81910233
133MP0002429_abnormal_blood_cell0.81165926
134MP0000609_abnormal_liver_physiology0.81144729
135MP0003828_pulmonary_edema0.81074524
136MP0003795_abnormal_bone_structure0.79629686
137MP0003690_abnormal_glial_cell0.79542104
138MP0000249_abnormal_blood_vessel0.79402086
139MP0008874_decreased_physiological_sensi0.79150063
140MP0005023_abnormal_wound_healing0.79045340
141MP0000358_abnormal_cell_content/0.78354993
142MP0000689_abnormal_spleen_morphology0.78201486
143MP0003763_abnormal_thymus_physiology0.77768633
144MP0005266_abnormal_metabolism0.76566110
145MP0002078_abnormal_glucose_homeostasis0.75952100
146MP0003878_abnormal_ear_physiology0.75890233
147MP0005377_hearing/vestibular/ear_phenot0.75890233
148MP0000013_abnormal_adipose_tissue0.75844723
149MP0004085_abnormal_heartbeat0.75683810
150MP0001756_abnormal_urination0.75090636
151MP0002138_abnormal_hepatobiliary_system0.73742986
152MP0002971_abnormal_brown_adipose0.73301430
153MP0003436_decreased_susceptibility_to0.73121635
154MP0002722_abnormal_immune_system0.71852819
155MP0001663_abnormal_digestive_system0.71425158
156MP0003329_amyloid_beta_deposits0.71160910
157MP0006082_CNS_inflammation0.69751820
158MP0004019_abnormal_vitamin_homeostasis0.68909523
159MP0001849_ear_inflammation0.68581920
160MP0002295_abnormal_pulmonary_circulatio0.67207715
161MP0001958_emphysema0.66616460
162MP0002127_abnormal_cardiovascular_syste0.66284746
163MP0000371_diluted_coat_color0.66208102
164MP0005499_abnormal_olfactory_system0.65968953
165MP0005394_taste/olfaction_phenotype0.65968953
166MP0009765_abnormal_xenobiotic_induced0.63587963
167MP0003879_abnormal_hair_cell0.63342578
168MP0005535_abnormal_body_temperature0.61612416

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.79206010
2Eczematoid dermatitis (HP:0000976)4.56284999
3Exercise-induced muscle cramps (HP:0003710)4.41519554
4Palpitations (HP:0001962)4.37476882
5Muscle fiber splitting (HP:0003555)4.31016260
6Asymmetric septal hypertrophy (HP:0001670)4.19514314
7Recurrent bacterial skin infections (HP:0005406)4.02902613
8Recurrent abscess formation (HP:0002722)3.98670861
9Hyporeflexia of lower limbs (HP:0002600)3.93474248
10Exercise-induced myalgia (HP:0003738)3.84498079
11Vacuolated lymphocytes (HP:0001922)3.82171325
12Myositis (HP:0100614)3.78585874
13Loss of speech (HP:0002371)3.76757319
14Myoglobinuria (HP:0002913)3.74829788
15Ventricular tachycardia (HP:0004756)3.74245313
16Orchitis (HP:0100796)3.71916025
17Right ventricular cardiomyopathy (HP:0011663)3.70621162
18Recurrent gram-negative bacterial infections (HP:0005420)3.49722761
19Calf muscle hypertrophy (HP:0008981)3.46255309
20Retrobulbar optic neuritis (HP:0100654)3.36725169
21Optic neuritis (HP:0100653)3.36725169
22Dysostosis multiplex (HP:0000943)3.35186204
23Axonal loss (HP:0003447)3.28900956
24Increased cerebral lipofuscin (HP:0011813)3.28190270
25Stomatitis (HP:0010280)3.21779005
26Syncope (HP:0001279)3.21417194
27Amyloidosis (HP:0011034)3.19605970
28Nuclear cataract (HP:0100018)3.14148259
29Muscle hypertrophy of the lower extremities (HP:0008968)3.13383736
30Mediastinal lymphadenopathy (HP:0100721)3.12408149
31Disinhibition (HP:0000734)2.98272195
32Neurofibrillary tangles (HP:0002185)2.95193506
33Increased connective tissue (HP:0009025)2.91463848
34EMG: myopathic abnormalities (HP:0003458)2.90266645
35Ketoacidosis (HP:0001993)2.89842779
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.84185635
37Rhabdomyolysis (HP:0003201)2.82955759
38Atrial fibrillation (HP:0005110)2.80093080
39Difficulty climbing stairs (HP:0003551)2.78818549
40Lipoatrophy (HP:0100578)2.77535779
41Abnormality of glycolipid metabolism (HP:0010969)2.74373641
42Abnormality of liposaccharide metabolism (HP:0010968)2.74373641
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.74373641
44Primary atrial arrhythmia (HP:0001692)2.74232892
45Mutism (HP:0002300)2.73870434
46Purpura (HP:0000979)2.73394474
47Glomerulonephritis (HP:0000099)2.72047619
48Increased serum ferritin (HP:0003281)2.71480259
49Hyperglycinuria (HP:0003108)2.70543730
50Ketosis (HP:0001946)2.70446434
51Abnormality of the calf musculature (HP:0001430)2.69946867
52Elevated erythrocyte sedimentation rate (HP:0003565)2.69556339
53Urinary glycosaminoglycan excretion (HP:0003541)2.66667302
54Mucopolysacchariduria (HP:0008155)2.66667302
55Abnormality of fatty-acid metabolism (HP:0004359)2.65455943
56Supraventricular tachycardia (HP:0004755)2.62489459
57Increased IgE level (HP:0003212)2.61349611
58Hypoglycemic coma (HP:0001325)2.60968383
59Chronic obstructive pulmonary disease (HP:0006510)2.60257955
60Obstructive lung disease (HP:0006536)2.60257955
61Myotonia (HP:0002486)2.56231058
62Supraventricular arrhythmia (HP:0005115)2.55189231
63Gingivitis (HP:0000230)2.53872629
64Complement deficiency (HP:0004431)2.51143022
65Abnormality of polysaccharide metabolism (HP:0011012)2.50106840
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50106840
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50106840
68Dilated cardiomyopathy (HP:0001644)2.49827403
69Hyperglycinemia (HP:0002154)2.45461817
70Abnormality of glycine metabolism (HP:0010895)2.44695523
71Abnormality of serine family amino acid metabolism (HP:0010894)2.44695523
72Muscle fiber inclusion bodies (HP:0100299)2.43138145
73Ventricular arrhythmia (HP:0004308)2.42518657
74Xanthomatosis (HP:0000991)2.42469778
75Difficulty running (HP:0009046)2.40598652
76Type 1 muscle fiber predominance (HP:0003803)2.40154857
77Hyperammonemia (HP:0001987)2.38945698
78Zonular cataract (HP:0010920)2.37887903
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37624879
80Dicarboxylic aciduria (HP:0003215)2.37624879
81Vertebral compression fractures (HP:0002953)2.36774649
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36552469
83Recurrent skin infections (HP:0001581)2.36157918
84Ulnar deviation of the wrist (HP:0003049)2.36132163
85Neuronal loss in central nervous system (HP:0002529)2.33959827
86Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33948876
87Malnutrition (HP:0004395)2.33855183
88Keratoconjunctivitis sicca (HP:0001097)2.32302014
89Abnormality of complement system (HP:0005339)2.32196591
90Atrioventricular block (HP:0001678)2.30346415
91Autoimmune thrombocytopenia (HP:0001973)2.30344649
92Prolonged QT interval (HP:0001657)2.29299511
93Myocardial infarction (HP:0001658)2.28836325
94Pulmonary infiltrates (HP:0002113)2.27491514
95Spontaneous hematomas (HP:0007420)2.25360362
96Late onset (HP:0003584)2.24608078
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24519784
98Muscle stiffness (HP:0003552)2.23211691
99Petechiae (HP:0000967)2.22795981
100Upper motor neuron abnormality (HP:0002127)2.22086347
101Cerebral inclusion bodies (HP:0100314)2.20434172
102Bundle branch block (HP:0011710)2.19699371
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18066789
104Testicular atrophy (HP:0000029)2.17392222
105Abnormality of iron homeostasis (HP:0011031)2.16659519
106Interstitial pulmonary disease (HP:0006530)2.16244492
107Hepatosplenomegaly (HP:0001433)2.14805317
108Progressive neurologic deterioration (HP:0002344)2.14273672
109Hematochezia (HP:0002573)2.13371805
110Recurrent fungal infections (HP:0002841)2.12661318
111Abnormality of the nasal mucosa (HP:0000433)2.11944510
112Vasculitis (HP:0002633)2.11291433
113Systemic lupus erythematosus (HP:0002725)2.10403364
114Gout (HP:0001997)2.09734445
115Hypoalphalipoproteinemia (HP:0003233)2.09258442
116Urticaria (HP:0001025)2.09077379
117Keratoconjunctivitis (HP:0001096)2.07474848
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07196465
119Hemoptysis (HP:0002105)2.07173040
120Areflexia of lower limbs (HP:0002522)2.07171254
121Pheochromocytoma (HP:0002666)2.07097598
122Apathy (HP:0000741)2.04396781
123Gastrointestinal infarctions (HP:0005244)2.04247593
124Foot dorsiflexor weakness (HP:0009027)2.03718408
125Retinal dysplasia (HP:0007973)2.02204770
126Heart block (HP:0012722)2.01705423
127Diminished motivation (HP:0000745)2.01278319
128Distal arthrogryposis (HP:0005684)2.01074506
129Ventricular fibrillation (HP:0001663)2.00071165
130Supranuclear gaze palsy (HP:0000605)1.99924956
131Meningitis (HP:0001287)1.99768862
132Abnormal atrioventricular conduction (HP:0005150)1.99761272
133Myopathic facies (HP:0002058)1.98575194
134Neoplasm of head and neck (HP:0012288)1.96691697
135Esophageal neoplasm (HP:0100751)1.96691697
136Distal lower limb muscle weakness (HP:0009053)1.96580287
137Conjunctival hamartoma (HP:0100780)1.96119060
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95068787
139Protuberant abdomen (HP:0001538)1.94760285
140Cellulitis (HP:0100658)1.93626196
141Prolonged neonatal jaundice (HP:0006579)1.92431158
142Chronic bronchitis (HP:0004469)1.92324919
143Episodic fever (HP:0001954)1.91085597
144Athetosis (HP:0002305)1.90055557
145Polyneuropathy (HP:0001271)1.88676799
146Neuroendocrine neoplasm (HP:0100634)1.88205847
147Pathologic fracture (HP:0002756)1.88010898
148Abnormality of the foot musculature (HP:0001436)1.87556619
149Dementia (HP:0000726)1.87175817
150Global brain atrophy (HP:0002283)1.86901363
151Gangrene (HP:0100758)1.86828833
152Cerebral edema (HP:0002181)1.84857261
153Hepatic necrosis (HP:0002605)1.84132171
154Hyperlipoproteinemia (HP:0010980)1.83035005
155Progressive muscle weakness (HP:0003323)1.82889545
156Nemaline bodies (HP:0003798)1.81883643
157Acute encephalopathy (HP:0006846)1.80577075
158Pustule (HP:0200039)1.78597007
159Cervical subluxation (HP:0003308)1.78574194
160Restrictive lung disease (HP:0002091)1.78552647
161Beaking of vertebral bodies (HP:0004568)1.77586929
162Segmental peripheral demyelination/remyelination (HP:0003481)1.77406018
163Acne (HP:0001061)1.77391317
164Abnormality of macrophages (HP:0004311)1.77012286
165Hypergammaglobulinemia (HP:0010702)1.76581068
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.75911094
167Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75834432
168Large for gestational age (HP:0001520)1.75585003
169Pulmonary embolism (HP:0002204)1.75507776
170Peripheral demyelination (HP:0011096)1.75228483
171Gingival bleeding (HP:0000225)1.75056034
172Increased CSF protein (HP:0002922)1.74803528
173Bulbar palsy (HP:0001283)1.74605481
174Epistaxis (HP:0000421)1.74044417
175Bone pain (HP:0002653)1.73758138
176Abnormality of transition element cation homeostasis (HP:0011030)1.73583565
177Colitis (HP:0002583)1.72997673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.63791470
2BCKDK4.00597743
3PHKG13.82308773
4PHKG23.82308773
5TTN3.75232368
6RIPK42.80666565
7OBSCN2.61149477
8ERN12.59848935
9PRPF4B2.53237203
10BLK2.50202211
11MAPKAPK32.42072590
12PDK32.36777187
13PDK42.36777187
14MAP3K142.15491468
15PKN22.12198578
16MAP4K12.08151678
17LMTK21.98440564
18NME21.94685216
19NEK11.79192685
20MAP3K31.77449784
21EPHB11.76732245
22IRAK31.73349759
23ZAP701.68457594
24PDK21.68121874
25FGR1.65855191
26MATK1.63729529
27CAMK2D1.51845151
28ICK1.50358619
29IKBKE1.47725459
30WNK41.47569842
31MAP3K131.42094614
32CDC42BPA1.40982479
33JAK31.35344479
34IKBKB1.35196652
35TESK11.34342512
36MAP2K31.30555531
37RIPK11.29253128
38STK241.27180986
39MYLK1.24424622
40MOS1.23774182
41PAK31.23338661
42FES1.22371274
43PINK11.21797086
44MAPK151.21422426
45TNK21.20777357
46PRKD31.19584789
47ARAF1.19377334
48EEF2K1.17005953
49JAK11.08605871
50PIM21.06507062
51TESK21.04937183
52LRRK21.04891295
53TRPM71.02154901
54ILK1.01300213
55NTRK11.00702820
56STK38L0.99536881
57MUSK0.99485237
58GRK60.99478901
59CAMKK20.96426921
60DAPK30.95614351
61SIK10.95522275
62MARK20.95123123
63CAMK2G0.91454951
64MAP3K110.91294723
65SYK0.90223416
66CAMK1D0.89897239
67SIK30.88967815
68HCK0.87626047
69JAK20.85877186
70TBK10.85829731
71FLT30.85539543
72LYN0.85406502
73CSF1R0.82755952
74MAP2K60.82584401
75KIT0.81513333
76RPS6KA20.81233706
77TXK0.81052427
78MAPK70.80490607
79MARK30.80291009
80PDPK10.79561370
81MET0.79117928
82STK390.78648928
83PTK60.77343047
84PRKD20.76928137
85IRAK20.76316305
86MAP3K60.75246428
87TYK20.75179267
88BTK0.73684842
89EPHA20.72461882
90PRKD10.70752858
91CHUK0.70257571
92IRAK10.69538083
93MAP2K20.68558891
94PIK3CG0.67096534
95DYRK1B0.66740453
96LCK0.66109964
97BMPR20.65610467
98MAPK120.61901949
99FGFR40.60820889
100SIK20.59705517
101ACVR1B0.59326687
102MAP3K50.58451098
103DAPK20.57428580
104FER0.56798186
105STK380.56759513
106CAMK2B0.54797421
107MAP3K20.54237747
108HIPK20.52016007
109MAPK40.51261519
110RPS6KL10.50464907
111RPS6KC10.50464907
112CAMKK10.49526173
113EPHA30.48722464
114RPS6KA60.48157269
115MAPKAPK20.47898299
116TGFBR20.46557782
117PRKAA10.46349161
118MAP3K10.45211651
119IRAK40.44496043
120PAK40.44176615
121PRKG20.43759352
122MST1R0.43695934
123LIMK10.43008460
124PDK10.42513296
125MTOR0.42198941
126PRKAA20.41927152
127ERBB30.41501901
128INSRR0.41102854
129MAP3K70.40776567
130PDGFRA0.40038958
131PTK2B0.40013385
132GRK70.39922972
133DDR20.39428931
134AKT20.38621999
135STK100.38018740
136FYN0.36764889
137ABL20.35916775
138ROCK20.35305574
139ROCK10.35018003
140PRKACG0.33699495
141SGK30.33069802
142TYRO30.32374301
143BRAF0.31893251
144MAP2K10.30959774
145PTK20.30958263
146TAOK10.30815464
147NEK90.30500149
148MAPK110.30279445
149BMX0.30222137
150CSK0.28623567
151KSR20.28592251
152TAOK20.27285769
153CAMK1G0.26343162

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.96311454
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.46559257
3Olfactory transduction_Homo sapiens_hsa047403.28055436
4Osteoclast differentiation_Homo sapiens_hsa043802.81544954
5Propanoate metabolism_Homo sapiens_hsa006402.77053239
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61600044
7Fatty acid degradation_Homo sapiens_hsa000712.57946132
8Leishmaniasis_Homo sapiens_hsa051402.40104851
9Carbon metabolism_Homo sapiens_hsa012002.37615386
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31491613
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30080549
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20770020
13Lysosome_Homo sapiens_hsa041422.19115496
14Other glycan degradation_Homo sapiens_hsa005112.14567930
15Malaria_Homo sapiens_hsa051442.06807376
16Pyruvate metabolism_Homo sapiens_hsa006202.01775066
17Rheumatoid arthritis_Homo sapiens_hsa053231.99576271
18Fatty acid metabolism_Homo sapiens_hsa012121.97418730
19Pertussis_Homo sapiens_hsa051331.96123226
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.85965585
21TNF signaling pathway_Homo sapiens_hsa046681.83353457
22Allograft rejection_Homo sapiens_hsa053301.80863060
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.78302226
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74393920
25Biosynthesis of amino acids_Homo sapiens_hsa012301.65613253
26Graft-versus-host disease_Homo sapiens_hsa053321.65306356
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.61709668
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58573693
29Cardiac muscle contraction_Homo sapiens_hsa042601.57167815
30Nitrogen metabolism_Homo sapiens_hsa009101.55382331
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51767852
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51435509
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47682663
34Salmonella infection_Homo sapiens_hsa051321.47252049
35Autoimmune thyroid disease_Homo sapiens_hsa053201.44640735
36Toxoplasmosis_Homo sapiens_hsa051451.44380730
37Parkinsons disease_Homo sapiens_hsa050121.43862824
38Oxidative phosphorylation_Homo sapiens_hsa001901.43802968
39beta-Alanine metabolism_Homo sapiens_hsa004101.42963429
40Galactose metabolism_Homo sapiens_hsa000521.42870407
41Starch and sucrose metabolism_Homo sapiens_hsa005001.42522423
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40142402
43B cell receptor signaling pathway_Homo sapiens_hsa046621.37348651
44PPAR signaling pathway_Homo sapiens_hsa033201.37338896
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36101886
46Asthma_Homo sapiens_hsa053101.35488048
47Peroxisome_Homo sapiens_hsa041461.34226190
48Fructose and mannose metabolism_Homo sapiens_hsa000511.32523981
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32066213
50Influenza A_Homo sapiens_hsa051641.31597355
51Dilated cardiomyopathy_Homo sapiens_hsa054141.29336397
52Arginine biosynthesis_Homo sapiens_hsa002201.28475686
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27594801
54Sulfur metabolism_Homo sapiens_hsa009201.24998532
55Acute myeloid leukemia_Homo sapiens_hsa052211.23933457
56Arginine and proline metabolism_Homo sapiens_hsa003301.21956379
57Fatty acid biosynthesis_Homo sapiens_hsa000611.19055812
58Pentose phosphate pathway_Homo sapiens_hsa000301.18478445
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.15886240
60Collecting duct acid secretion_Homo sapiens_hsa049661.15409811
61African trypanosomiasis_Homo sapiens_hsa051431.15119076
62Histidine metabolism_Homo sapiens_hsa003401.13936826
63Sulfur relay system_Homo sapiens_hsa041221.13507999
64Antigen processing and presentation_Homo sapiens_hsa046121.13143781
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12605485
66Type I diabetes mellitus_Homo sapiens_hsa049401.11891842
67Folate biosynthesis_Homo sapiens_hsa007901.11588980
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11279762
69Vibrio cholerae infection_Homo sapiens_hsa051101.11215914
70Hematopoietic cell lineage_Homo sapiens_hsa046401.11014869
71Butanoate metabolism_Homo sapiens_hsa006501.10353597
72Chemokine signaling pathway_Homo sapiens_hsa040621.09436906
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08893199
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08837238
75Viral myocarditis_Homo sapiens_hsa054161.07155627
76Amoebiasis_Homo sapiens_hsa051461.06741726
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02691598
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.02331990
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01143627
80Adipocytokine signaling pathway_Homo sapiens_hsa049201.00730996
81Hepatitis C_Homo sapiens_hsa051601.00580770
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98859951
83Tryptophan metabolism_Homo sapiens_hsa003800.97963418
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97414897
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96574980
86Measles_Homo sapiens_hsa051620.96322452
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96180997
88Staphylococcus aureus infection_Homo sapiens_hsa051500.95562022
89Fatty acid elongation_Homo sapiens_hsa000620.94463363
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94084697
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.93701117
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92710619
93Alzheimers disease_Homo sapiens_hsa050100.92024575
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.91638027
95Shigellosis_Homo sapiens_hsa051310.91338121
96Bladder cancer_Homo sapiens_hsa052190.87565933
97Herpes simplex infection_Homo sapiens_hsa051680.86332514
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85070339
99Phenylalanine metabolism_Homo sapiens_hsa003600.84827263
100Fat digestion and absorption_Homo sapiens_hsa049750.83784265
101Hepatitis B_Homo sapiens_hsa051610.82700895
102Insulin resistance_Homo sapiens_hsa049310.82346899
103VEGF signaling pathway_Homo sapiens_hsa043700.82286513
104Steroid biosynthesis_Homo sapiens_hsa001000.82234995
105T cell receptor signaling pathway_Homo sapiens_hsa046600.80122844
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.79211214
107Glycerolipid metabolism_Homo sapiens_hsa005610.78974129
108Glucagon signaling pathway_Homo sapiens_hsa049220.77886907
109Apoptosis_Homo sapiens_hsa042100.76849628
110Phagosome_Homo sapiens_hsa041450.76685015
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76116158
112Bile secretion_Homo sapiens_hsa049760.76075377
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76030483
114Glutathione metabolism_Homo sapiens_hsa004800.75570616
115Regulation of autophagy_Homo sapiens_hsa041400.73422144
116Insulin signaling pathway_Homo sapiens_hsa049100.72916825
117Selenocompound metabolism_Homo sapiens_hsa004500.72363946
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68547234
119Sphingolipid metabolism_Homo sapiens_hsa006000.66711380
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.66115033
121Complement and coagulation cascades_Homo sapiens_hsa046100.66068932
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.66029207
123Mineral absorption_Homo sapiens_hsa049780.64203999
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63357681
125Legionellosis_Homo sapiens_hsa051340.62819032
126Endocytosis_Homo sapiens_hsa041440.62574441
127Prion diseases_Homo sapiens_hsa050200.59747615
128Primary immunodeficiency_Homo sapiens_hsa053400.59505730
129Prolactin signaling pathway_Homo sapiens_hsa049170.59090837
130Notch signaling pathway_Homo sapiens_hsa043300.58926081
131Huntingtons disease_Homo sapiens_hsa050160.58655330
132GnRH signaling pathway_Homo sapiens_hsa049120.57940485
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53853271
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53689997
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52804494
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51725753
137Metabolic pathways_Homo sapiens_hsa011000.50859814
138Platelet activation_Homo sapiens_hsa046110.50121840
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49900029
140Tuberculosis_Homo sapiens_hsa051520.49069864
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48185011
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.47996527
143Tyrosine metabolism_Homo sapiens_hsa003500.47603504
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.47391870
145Proteasome_Homo sapiens_hsa030500.45518772
146Chronic myeloid leukemia_Homo sapiens_hsa052200.45264577
147HIF-1 signaling pathway_Homo sapiens_hsa040660.44671333
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42919388
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42784764
150Arachidonic acid metabolism_Homo sapiens_hsa005900.41189707
151Caffeine metabolism_Homo sapiens_hsa002320.40479240
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40008489
153Pancreatic cancer_Homo sapiens_hsa052120.39962174
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38463974
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38267363
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36637115
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35703214
158Renal cell carcinoma_Homo sapiens_hsa052110.34838472
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34680602
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.34383102
161AMPK signaling pathway_Homo sapiens_hsa041520.33047597
162Non-small cell lung cancer_Homo sapiens_hsa052230.32759306
163Epstein-Barr virus infection_Homo sapiens_hsa051690.32648272
164Type II diabetes mellitus_Homo sapiens_hsa049300.32460247
165Pancreatic secretion_Homo sapiens_hsa049720.32127398
166Chemical carcinogenesis_Homo sapiens_hsa052040.31015981
167Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30643294
168ABC transporters_Homo sapiens_hsa020100.30315512
169Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29772139
170MAPK signaling pathway_Homo sapiens_hsa040100.28848656
171Insulin secretion_Homo sapiens_hsa049110.28185564
172FoxO signaling pathway_Homo sapiens_hsa040680.27808615
173Central carbon metabolism in cancer_Homo sapiens_hsa052300.27319689
174Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26135095
175Synaptic vesicle cycle_Homo sapiens_hsa047210.25204339

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