TOM1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.48568391
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28785530
3locomotory exploration behavior (GO:0035641)5.04437009
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74069100
5glutamate secretion (GO:0014047)4.54318971
6synaptic vesicle exocytosis (GO:0016079)4.52108059
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46963898
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.34630896
9vocalization behavior (GO:0071625)4.27922394
10regulation of synaptic vesicle exocytosis (GO:2000300)4.26286655
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.16884898
12sodium ion export (GO:0071436)4.13683969
13neuronal action potential propagation (GO:0019227)4.02091357
14cellular potassium ion homeostasis (GO:0030007)4.01945872
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99506597
16regulation of synapse structural plasticity (GO:0051823)3.89645040
17neurotransmitter secretion (GO:0007269)3.88120680
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86474545
19regulation of synaptic vesicle transport (GO:1902803)3.84344081
20regulation of glutamate receptor signaling pathway (GO:1900449)3.83756857
21cell communication by electrical coupling (GO:0010644)3.83312055
22layer formation in cerebral cortex (GO:0021819)3.68339268
23cerebellar granule cell differentiation (GO:0021707)3.63402530
24activation of protein kinase A activity (GO:0034199)3.62195979
25regulation of neuronal synaptic plasticity (GO:0048168)3.62038185
26exploration behavior (GO:0035640)3.58693948
27proline transport (GO:0015824)3.51977044
28cardiac muscle contraction (GO:0060048)3.47536115
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45289191
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.42236615
31gamma-aminobutyric acid transport (GO:0015812)3.42087166
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38755723
33potassium ion import (GO:0010107)3.38114225
34protein localization to synapse (GO:0035418)3.35244664
35cell communication involved in cardiac conduction (GO:0086065)3.22320452
36glycine transport (GO:0015816)3.21708042
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19518498
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15477015
39neuromuscular process controlling posture (GO:0050884)3.15342932
40synaptic transmission, glutamatergic (GO:0035249)3.14970319
41neurotransmitter transport (GO:0006836)3.13272064
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11776996
43long-term memory (GO:0007616)3.10986285
44cerebellar Purkinje cell differentiation (GO:0021702)3.10198119
45neurotransmitter-gated ion channel clustering (GO:0072578)3.08695273
46dendritic spine morphogenesis (GO:0060997)3.08330373
47neuromuscular process controlling balance (GO:0050885)3.07737232
48membrane depolarization during action potential (GO:0086010)3.04114238
49neuron cell-cell adhesion (GO:0007158)3.01936594
50L-amino acid import (GO:0043092)2.99819465
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98467537
52neuron-neuron synaptic transmission (GO:0007270)2.98255443
53potassium ion homeostasis (GO:0055075)2.97790619
54cardiac myofibril assembly (GO:0055003)2.97788153
55regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96640548
56glutamate receptor signaling pathway (GO:0007215)2.96418421
57regulation of ARF protein signal transduction (GO:0032012)2.94913509
58regulation of cell communication by electrical coupling (GO:0010649)2.93547307
59positive regulation of membrane potential (GO:0045838)2.93038258
60positive regulation of potassium ion transmembrane transport (GO:1901381)2.92111167
61regulation of neurotransmitter levels (GO:0001505)2.92092303
62cellular sodium ion homeostasis (GO:0006883)2.91956349
63regulation of actin filament-based movement (GO:1903115)2.90763162
64amino acid import (GO:0043090)2.87978548
65regulation of synaptic plasticity (GO:0048167)2.87307748
66sarcomere organization (GO:0045214)2.87144989
67regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86024593
68regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.85919127
69dendrite morphogenesis (GO:0048813)2.85882253
70regulation of membrane repolarization (GO:0060306)2.84431757
71membrane repolarization (GO:0086009)2.83749375
72detection of calcium ion (GO:0005513)2.82972331
73regulation of postsynaptic membrane potential (GO:0060078)2.82020463
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80892796
75regulation of neurotransmitter secretion (GO:0046928)2.79669020
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.78476761
77regulation of dendritic spine morphogenesis (GO:0061001)2.78250343
78neuronal ion channel clustering (GO:0045161)2.76784223
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76639489
80prepulse inhibition (GO:0060134)2.76210501
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75481114
82cellular response to monoamine stimulus (GO:0071868)2.74977535
83cellular response to catecholamine stimulus (GO:0071870)2.74977535
84vesicle transport along microtubule (GO:0047496)2.74467862
85synaptic vesicle endocytosis (GO:0048488)2.73875027
86positive regulation of synapse maturation (GO:0090129)2.73122663
87regulation of voltage-gated calcium channel activity (GO:1901385)2.70246873
88cellular response to epinephrine stimulus (GO:0071872)2.70236673
89plasma membrane repair (GO:0001778)2.68685072
90myofibril assembly (GO:0030239)2.68513019
91striated muscle contraction (GO:0006941)2.68112616
92membrane hyperpolarization (GO:0060081)2.68003408
93regulation of calcium ion transmembrane transporter activity (GO:1901019)2.67791820
94regulation of calcium ion transmembrane transport (GO:1903169)2.67791820
95muscle filament sliding (GO:0030049)2.67650001
96actin-myosin filament sliding (GO:0033275)2.67650001
97regulation of the force of heart contraction (GO:0002026)2.67395236
98positive regulation of potassium ion transport (GO:0043268)2.67046278
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.66888344
100membrane depolarization (GO:0051899)2.65167776
101regulation of synapse maturation (GO:0090128)2.64665499
102cardiac muscle hypertrophy (GO:0003300)2.64329911
103positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63766562
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.63138564
105regulation of neurotransmitter transport (GO:0051588)2.62785617
106negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62540649
107cerebellar Purkinje cell layer development (GO:0021680)2.62228881
108long-term synaptic potentiation (GO:0060291)2.61840029
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.61400933
110auditory behavior (GO:0031223)2.59093003
111transmission of nerve impulse (GO:0019226)2.58844273
112positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58622755
113sarcoplasmic reticulum calcium ion transport (GO:0070296)2.58299489
114regulation of vesicle fusion (GO:0031338)2.58295870
115alanine transport (GO:0032328)2.58255985
116response to auditory stimulus (GO:0010996)2.58144679
117positive regulation of sodium ion transport (GO:0010765)2.57934309
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.57548242
119establishment of nucleus localization (GO:0040023)2.57475526
120regulation of clathrin-mediated endocytosis (GO:2000369)2.56068588
121cardiac conduction (GO:0061337)2.53634396
122dendritic spine organization (GO:0097061)2.52380866
123desmosome organization (GO:0002934)2.52241869
124positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.51762122
125striated muscle hypertrophy (GO:0014897)2.48919336
126adherens junction assembly (GO:0034333)2.45912406
127protein targeting to plasma membrane (GO:0072661)2.45047327
128cell-substrate adherens junction assembly (GO:0007045)2.44673297
129focal adhesion assembly (GO:0048041)2.44673297
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.42799161
131response to catecholamine (GO:0071869)2.40094399
132response to monoamine (GO:0071867)2.40094399
133regulation of cardiac muscle cell contraction (GO:0086004)2.39177525
134relaxation of cardiac muscle (GO:0055119)2.39069144
135cardiac muscle hypertrophy in response to stress (GO:0014898)2.36539116
136muscle hypertrophy in response to stress (GO:0003299)2.36539116
137cardiac muscle adaptation (GO:0014887)2.36539116
138ventricular cardiac muscle cell action potential (GO:0086005)2.36201741
139neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35298696
140central nervous system myelination (GO:0022010)2.35037192
141axon ensheathment in central nervous system (GO:0032291)2.35037192
142actin filament depolymerization (GO:0030042)2.30265478
143postsynaptic membrane organization (GO:0001941)2.28337071
144cell-substrate junction assembly (GO:0007044)2.28158955
145actomyosin structure organization (GO:0031032)2.28155556
146response to epinephrine (GO:0071871)2.27750662
147dopamine receptor signaling pathway (GO:0007212)2.26366746
148positive regulation of dendritic spine development (GO:0060999)2.26357974
149cAMP biosynthetic process (GO:0006171)2.25023690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73797652
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77008394
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72083368
4DROSHA_22980978_ChIP-Seq_HELA_Human2.61141470
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55220195
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55220195
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53131754
8GBX2_23144817_ChIP-Seq_PC3_Human2.45351457
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.44830811
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41724051
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37033613
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35037864
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.30937674
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29984776
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25889267
16REST_21632747_ChIP-Seq_MESCs_Mouse2.24822177
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22773695
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15728320
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11910523
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.08978069
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06979596
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.06190157
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02410679
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.97283052
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94913017
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.93453894
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.88699459
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74797317
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61142652
30AR_21572438_ChIP-Seq_LNCaP_Human1.60553530
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58807476
32RACK7_27058665_Chip-Seq_MCF-7_Human1.51440785
33* ERG_21242973_ChIP-ChIP_JURKAT_Human1.50002829
34KDM2B_26808549_Chip-Seq_DND41_Human1.49997263
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49087770
36TBX20_22328084_ChIP-Seq_HEART_Mouse1.46636122
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.46636122
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42898090
39KDM2B_26808549_Chip-Seq_K562_Human1.42467987
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41825242
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41548027
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41263143
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41222611
44* ESR1_21235772_ChIP-Seq_MCF-7_Human1.37603900
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36296184
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34653688
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34614943
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32704760
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32013428
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31867550
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28803462
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.28674199
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26361465
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.25686084
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24091102
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.23712870
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.22221328
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22094625
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21045424
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20812224
61* EP300_21415370_ChIP-Seq_HL-1_Mouse1.19993231
62TCF7_22412390_ChIP-Seq_EML_Mouse1.19948493
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19358955
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19043925
65AR_19668381_ChIP-Seq_PC3_Human1.19037618
66* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16118068
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15545212
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15182351
69CREB1_26743006_Chip-Seq_LNCaP_Human1.14649612
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14524538
71* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14255854
72CLOCK_20551151_ChIP-Seq_293T_Human1.13741341
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.13064820
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12890674
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12030787
76ZNF274_21170338_ChIP-Seq_K562_Hela1.11586650
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11459592
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11102435
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10718473
80* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10066999
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09694731
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09680576
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08883995
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08702869
85* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08560441
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.07751007
87* ESR2_21235772_ChIP-Seq_MCF-7_Human1.07340052
88AHR_22903824_ChIP-Seq_MCF-7_Human1.05165498
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04909833
90* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04701940
91STAT3_23295773_ChIP-Seq_U87_Human1.03341578
92P68_20966046_ChIP-Seq_HELA_Human1.02506866
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02083472
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01515567
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00945323
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.00751964
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00570052
98* CTCF_27219007_Chip-Seq_Bcells_Human1.00472854
99TP63_22573176_ChIP-Seq_HFKS_Human1.00234022
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.00101897
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.00029168
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.99771480
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99556628
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.99370308
105CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99155928
106AR_25329375_ChIP-Seq_VCAP_Human0.98726313
107* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98646093
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98310722
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97957484
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.97329120
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97163240
112* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96885072
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.96695706
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96196429
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.95838136
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.95740573
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95304196
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.94166410
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93149636
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92875832
121RXR_22108803_ChIP-Seq_LS180_Human0.92750475
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92515343
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91648351
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.91295271
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90880620
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.90298590
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87993168
128* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87172032
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87119437
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87061999
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86898682
132* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86745103
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.86494606
134KLF4_19829295_ChIP-Seq_ESCs_Human0.85984808
135LXR_22292898_ChIP-Seq_THP-1_Human0.84878032
136TP53_16413492_ChIP-PET_HCT116_Human0.84666486
137TCF4_23295773_ChIP-Seq_U87_Human0.84284914
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83177997
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82303760
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82253475
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82138758
142SMC4_20622854_ChIP-Seq_HELA_Human0.81915751
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81398256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03143941
2MP0003635_abnormal_synaptic_transmissio3.62793462
3MP0004270_analgesia3.60088241
4MP0003880_abnormal_central_pattern3.42083707
5MP0003705_abnormal_hypodermis_morpholog2.92792517
6MP0002822_catalepsy2.84330885
7MP0009745_abnormal_behavioral_response2.80820891
8MP0009046_muscle_twitch2.80138124
9MP0002063_abnormal_learning/memory/cond2.75171077
10MP0002064_seizures2.74092961
11MP0001968_abnormal_touch/_nociception2.40575855
12MP0000751_myopathy2.37220285
13MP0002734_abnormal_mechanical_nocicepti2.36125835
14MP0002272_abnormal_nervous_system2.31578480
15MP0002837_dystrophic_cardiac_calcinosis2.29450485
16MP0005423_abnormal_somatic_nervous2.28439758
17MP0009780_abnormal_chondrocyte_physiolo2.26387771
18MP0002909_abnormal_adrenal_gland2.24220872
19* MP0002572_abnormal_emotion/affect_behav2.18914724
20MP0001486_abnormal_startle_reflex2.13124629
21MP0004858_abnormal_nervous_system2.11053104
22MP0008569_lethality_at_weaning1.99912946
23MP0005409_darkened_coat_color1.99719767
24MP0003329_amyloid_beta_deposits1.99693988
25MP0001501_abnormal_sleep_pattern1.84203218
26MP0002735_abnormal_chemical_nociception1.81901372
27MP0002733_abnormal_thermal_nociception1.79201271
28MP0001970_abnormal_pain_threshold1.71456859
29MP0001440_abnormal_grooming_behavior1.70885489
30MP0002736_abnormal_nociception_after1.69546185
31MP0002067_abnormal_sensory_capabilities1.67590264
32MP0003646_muscle_fatigue1.67288617
33MP0004215_abnormal_myocardial_fiber1.65271487
34MP0004885_abnormal_endolymph1.63919451
35MP0003279_aneurysm1.61135707
36MP0004145_abnormal_muscle_electrophysio1.56478747
37MP0008438_abnormal_cutaneous_collagen1.56296973
38MP0004811_abnormal_neuron_physiology1.55415462
39MP0005386_behavior/neurological_phenoty1.49708203
40MP0004924_abnormal_behavior1.49708203
41MP0000013_abnormal_adipose_tissue1.46768280
42MP0008961_abnormal_basal_metabolism1.43929784
43MP0002184_abnormal_innervation1.40221257
44MP0004036_abnormal_muscle_relaxation1.39368262
45MP0004130_abnormal_muscle_cell1.38800337
46MP0003633_abnormal_nervous_system1.37833886
47MP0002557_abnormal_social/conspecific_i1.36411192
48MP0003566_abnormal_cell_adhesion1.36092984
49MP0000955_abnormal_spinal_cord1.35872873
50MP0003879_abnormal_hair_cell1.35661482
51MP0004084_abnormal_cardiac_muscle1.33881155
52MP0005670_abnormal_white_adipose1.33672632
53MP0005275_abnormal_skin_tensile1.33013528
54MP0000579_abnormal_nail_morphology1.32775642
55MP0003283_abnormal_digestive_organ1.29720621
56MP0005646_abnormal_pituitary_gland1.29082174
57MP0004043_abnormal_pH_regulation1.28433427
58* MP0002066_abnormal_motor_capabilities/c1.26379066
59MP0000778_abnormal_nervous_system1.23633233
60MP0004085_abnormal_heartbeat1.22157613
61MP0002882_abnormal_neuron_morphology1.21690929
62MP0004233_abnormal_muscle_weight1.21416945
63MP0001348_abnormal_lacrimal_gland1.21409379
64* MP0001958_emphysema1.20351645
65MP0000747_muscle_weakness1.19393233
66MP0010630_abnormal_cardiac_muscle1.18075703
67MP0003137_abnormal_impulse_conducting1.13931554
68MP0000749_muscle_degeneration1.13226620
69MP0001502_abnormal_circadian_rhythm1.12636084
70MP0006276_abnormal_autonomic_nervous1.10858280
71MP0003631_nervous_system_phenotype1.10297593
72MP0004484_altered_response_of1.09086035
73MP0003690_abnormal_glial_cell1.08644293
74MP0002249_abnormal_larynx_morphology1.05388972
75MP0005620_abnormal_muscle_contractility1.05104402
76MP0001984_abnormal_olfaction1.04474116
77MP0000750_abnormal_muscle_regeneration1.02698994
78MP0001849_ear_inflammation1.01772461
79MP0002229_neurodegeneration1.01233537
80MP0005167_abnormal_blood-brain_barrier0.99029138
81MP0000569_abnormal_digit_pigmentation0.97826289
82MP0005535_abnormal_body_temperature0.97775337
83MP0008260_abnormal_autophagy0.97418583
84MP0005058_abnormal_lysosome_morphology0.97078661
85MP0004087_abnormal_muscle_fiber0.97026346
86MP0005666_abnormal_adipose_tissue0.96997211
87MP0003091_abnormal_cell_migration0.96758822
88MP0005385_cardiovascular_system_phenoty0.96205994
89MP0001544_abnormal_cardiovascular_syste0.96205994
90MP0005623_abnormal_meninges_morphology0.95921426
91MP0003634_abnormal_glial_cell0.95349328
92MP0003075_altered_response_to0.95255904
93MP0010368_abnormal_lymphatic_system0.95110663
94MP0000920_abnormal_myelination0.94323856
95MP0002972_abnormal_cardiac_muscle0.93904158
96MP0005503_abnormal_tendon_morphology0.93023204
97MP0005375_adipose_tissue_phenotype0.92342541
98MP0002090_abnormal_vision0.90684715
99MP0008874_decreased_physiological_sensi0.90368792
100MP0009384_cardiac_valve_regurgitation0.88883128
101MP0000604_amyloidosis0.87102402
102MP0004142_abnormal_muscle_tone0.86300350
103MP0005165_increased_susceptibility_to0.86277972
104MP0005551_abnormal_eye_electrophysiolog0.85890980
105MP0005330_cardiomyopathy0.84920388
106MP0002269_muscular_atrophy0.84555783
107MP0003172_abnormal_lysosome_physiology0.84178872
108MP0002069_abnormal_eating/drinking_beha0.83638054
109MP0002332_abnormal_exercise_endurance0.82293351
110* MP0002152_abnormal_brain_morphology0.82202801
111MP0002108_abnormal_muscle_morphology0.81457377
112MP0000733_abnormal_muscle_development0.81076730
113MP0010234_abnormal_vibrissa_follicle0.78840181
114MP0005645_abnormal_hypothalamus_physiol0.78456945
115MP0003191_abnormal_cellular_cholesterol0.77411465
116MP0003045_fibrosis0.77093558
117MP0003632_abnormal_nervous_system0.76380813
118MP0002896_abnormal_bone_mineralization0.76091502
119MP0008872_abnormal_physiological_respon0.75939558
120MP0010386_abnormal_urinary_bladder0.75625675
121MP0001905_abnormal_dopamine_level0.75389203
122MP0000759_abnormal_skeletal_muscle0.75218506
123MP0000003_abnormal_adipose_tissue0.74593714
124MP0001177_atelectasis0.74392651
125MP0004510_myositis0.74310007
126MP0005595_abnormal_vascular_smooth0.74263201
127MP0002106_abnormal_muscle_physiology0.72638805
128MP0003122_maternal_imprinting0.70396718
129MP0006138_congestive_heart_failure0.70012413
130MP0003787_abnormal_imprinting0.69727328
131MP0008775_abnormal_heart_ventricle0.69402744
132MP0005369_muscle_phenotype0.66038714

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.84605241
2Focal motor seizures (HP:0011153)5.44498613
3Focal seizures (HP:0007359)4.47095801
4Visual hallucinations (HP:0002367)4.27339502
5Action tremor (HP:0002345)4.05793328
6Obstructive sleep apnea (HP:0002870)3.96823202
7Ventricular fibrillation (HP:0001663)3.53026608
8Supranuclear gaze palsy (HP:0000605)3.48374358
9Ankle clonus (HP:0011448)3.47635575
10Distal lower limb muscle weakness (HP:0009053)3.41287098
11Atonic seizures (HP:0010819)3.40782066
12Progressive cerebellar ataxia (HP:0002073)3.37012352
13Bundle branch block (HP:0011710)3.33664627
14Epileptic encephalopathy (HP:0200134)3.29239795
15Type 1 muscle fiber predominance (HP:0003803)3.24291306
16Generalized tonic-clonic seizures (HP:0002069)3.10862666
17Ventricular tachycardia (HP:0004756)3.07667141
18Exercise-induced myalgia (HP:0003738)3.04120677
19Absence seizures (HP:0002121)3.04115961
20Depression (HP:0000716)3.03964078
21Febrile seizures (HP:0002373)3.02657667
22Sudden death (HP:0001699)3.00005881
23Postural instability (HP:0002172)2.99680662
24Increased connective tissue (HP:0009025)2.89093781
25Asymmetric septal hypertrophy (HP:0001670)2.87756404
26Dysdiadochokinesis (HP:0002075)2.87585461
27Pheochromocytoma (HP:0002666)2.84730757
28Right ventricular cardiomyopathy (HP:0011663)2.82298335
29Dysmetric saccades (HP:0000641)2.81684801
30Impaired vibration sensation in the lower limbs (HP:0002166)2.78891886
31Urinary bladder sphincter dysfunction (HP:0002839)2.77491034
32Poor eye contact (HP:0000817)2.71096876
33Abnormal social behavior (HP:0012433)2.70819853
34Impaired social interactions (HP:0000735)2.70819853
35Anxiety (HP:0000739)2.70457285
36Dialeptic seizures (HP:0011146)2.69304171
37Distal lower limb amyotrophy (HP:0008944)2.68675795
38Dysmetria (HP:0001310)2.68044439
39Cerebral aneurysm (HP:0004944)2.68038403
40Mildly elevated creatine phosphokinase (HP:0008180)2.65385700
41Protrusio acetabuli (HP:0003179)2.64279589
42Prolonged QT interval (HP:0001657)2.63812105
43EMG: neuropathic changes (HP:0003445)2.56961139
44Urinary urgency (HP:0000012)2.55135444
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.54892254
46Abnormal eating behavior (HP:0100738)2.54215152
47Gaze-evoked nystagmus (HP:0000640)2.53396162
48Torticollis (HP:0000473)2.52397427
49Syncope (HP:0001279)2.52323508
50Abnormality of the lower motor neuron (HP:0002366)2.51896192
51Abnormality of skeletal muscle fiber size (HP:0012084)2.51619758
52Truncal ataxia (HP:0002078)2.49204388
53Hemiplegia (HP:0002301)2.47494824
54Foot dorsiflexor weakness (HP:0009027)2.47449420
55EMG: myopathic abnormalities (HP:0003458)2.46656633
56Broad-based gait (HP:0002136)2.44744177
57Abnormality of binocular vision (HP:0011514)2.44666416
58Diplopia (HP:0000651)2.44666416
59Papilledema (HP:0001085)2.44469304
60Intention tremor (HP:0002080)2.41924516
61Abnormality of the foot musculature (HP:0001436)2.39436308
62Abnormal EKG (HP:0003115)2.38364546
63Genetic anticipation (HP:0003743)2.37567536
64Neuroendocrine neoplasm (HP:0100634)2.35101083
65Upper limb amyotrophy (HP:0009129)2.33870993
66Distal upper limb amyotrophy (HP:0007149)2.33870993
67Difficulty climbing stairs (HP:0003551)2.32574101
68Hyporeflexia of lower limbs (HP:0002600)2.30394890
69Spastic gait (HP:0002064)2.29756302
70Termporal pattern (HP:0011008)2.29188665
71Insidious onset (HP:0003587)2.29188665
72Megalencephaly (HP:0001355)2.26846292
73Focal dystonia (HP:0004373)2.26459527
74Difficulty running (HP:0009046)2.25063058
75Lipoatrophy (HP:0100578)2.23558971
76Neurofibrillary tangles (HP:0002185)2.22962119
77Myotonia (HP:0002486)2.21635015
78Rapidly progressive (HP:0003678)2.19405037
79Aortic aneurysm (HP:0004942)2.19267974
80Shallow orbits (HP:0000586)2.18919130
81Atrial fibrillation (HP:0005110)2.18687559
82Heart block (HP:0012722)2.18677288
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.16435282
84Lower limb muscle weakness (HP:0007340)2.15307264
85Cerebral inclusion bodies (HP:0100314)2.14455764
86Primary atrial arrhythmia (HP:0001692)2.13813127
87Ventricular arrhythmia (HP:0004308)2.12884359
88Mutism (HP:0002300)2.11679347
89Broad face (HP:0000283)2.11058088
90Calf muscle hypertrophy (HP:0008981)2.11023061
91Bradykinesia (HP:0002067)2.10528377
92Insomnia (HP:0100785)2.09758149
93Round ear (HP:0100830)2.09595934
94Resting tremor (HP:0002322)2.08121235
95Craniofacial dystonia (HP:0012179)2.08109558
96Exercise-induced muscle cramps (HP:0003710)2.07299954
97Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06973994
98Muscle fiber inclusion bodies (HP:0100299)2.06872281
99Spinal rigidity (HP:0003306)2.04439639
100Vascular tortuosity (HP:0004948)2.03962897
101Hyperacusis (HP:0010780)2.01175438
102Abnormal atrioventricular conduction (HP:0005150)2.00681615
103Arterial tortuosity (HP:0005116)2.00577226
104Subaortic stenosis (HP:0001682)1.99936525
105Abnormality of the left ventricular outflow tract (HP:0011103)1.99936525
106Scanning speech (HP:0002168)1.99769660
107Increased variability in muscle fiber diameter (HP:0003557)1.99246912
108Dilated cardiomyopathy (HP:0001644)1.98410022
109Neck muscle weakness (HP:0000467)1.98288307
110Abnormality of the calf musculature (HP:0001430)1.98283423
111Impaired smooth pursuit (HP:0007772)1.97967020
112Muscle hypertrophy of the lower extremities (HP:0008968)1.96835670
113Supraventricular tachycardia (HP:0004755)1.96199960
114Hyperventilation (HP:0002883)1.95455381
115Aneurysm (HP:0002617)1.95209540
116Impaired vibratory sensation (HP:0002495)1.93429570
117Status epilepticus (HP:0002133)1.93408566
118Hemiparesis (HP:0001269)1.92845708
119Amblyopia (HP:0000646)1.92843006
120Supraventricular arrhythmia (HP:0005115)1.92311093
121Lower limb amyotrophy (HP:0007210)1.91290609
122Nemaline bodies (HP:0003798)1.91031787
123Bradycardia (HP:0001662)1.90204541
124Atrioventricular block (HP:0001678)1.89566614
125Mitral regurgitation (HP:0001653)1.89539210
126Premature rupture of membranes (HP:0001788)1.89303962
127Central scotoma (HP:0000603)1.88258102
128Postural tremor (HP:0002174)1.87995112
129Rigidity (HP:0002063)1.87372802
130Neoplasm of the peripheral nervous system (HP:0100007)1.86447680
131Neuronal loss in central nervous system (HP:0002529)1.86344467
132Sudden cardiac death (HP:0001645)1.86201501
133Annular pancreas (HP:0001734)1.86059206
134Akinesia (HP:0002304)1.86030207
135Scapular winging (HP:0003691)1.85532831
136Agitation (HP:0000713)1.84413445
137EEG with generalized epileptiform discharges (HP:0011198)1.84295668
138Hypercortisolism (HP:0001578)1.84264055
139Stereotypic behavior (HP:0000733)1.84037807
140Epileptiform EEG discharges (HP:0011182)1.83891273
141Clonus (HP:0002169)1.83852817
142Pointed chin (HP:0000307)1.82776127
143Hypsarrhythmia (HP:0002521)1.80308727
144Myopathic facies (HP:0002058)1.79998155
145Neoplasm of the heart (HP:0100544)1.79748052
146Fragile skin (HP:0001030)1.79711882
147Increased circulating renin level (HP:0000848)1.79404663
148Axonal loss (HP:0003447)1.79079240
149Muscle fiber splitting (HP:0003555)1.77942819
150Atrophic scars (HP:0001075)1.77425885
151Bronchomalacia (HP:0002780)1.74761244
152Hand muscle atrophy (HP:0009130)1.74420173
153Tetraplegia (HP:0002445)1.74270947
154Lymphangioma (HP:0100764)1.73906630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.54735776
2MAP3K93.54113073
3EPHA43.21412825
4PRKD32.59511103
5MAP3K42.58574137
6PAK62.49197665
7KSR22.39889940
8MINK12.24845735
9DAPK22.20750523
10NTRK12.15248539
11LMTK22.05996185
12MARK12.01618643
13CAMKK11.97423516
14PHKG11.90961931
15PHKG21.90961931
16SIK11.89241267
17MYLK1.83353861
18NTRK21.77421198
19MAP2K41.75323137
20STK381.74932521
21MAP2K71.61684061
22TRIB31.47211516
23MAPK121.44329738
24CDK51.38541842
25RIPK11.38196131
26OBSCN1.36012461
27TESK11.34803028
28PINK11.32407628
29MAP3K21.30971178
30KSR11.28248069
31TAOK11.26501317
32TYRO31.22280403
33RET1.20463764
34LATS21.20451451
35PAK31.20326142
36PRKCH1.18306611
37CAMKK21.16866463
38DMPK1.13511849
39ERN11.13264279
40SGK2231.09760734
41SGK4941.09760734
42WNK11.08706348
43EPHB11.07620551
44EEF2K1.07275563
45GRK51.04063887
46SGK31.03731414
47ARAF1.03077955
48PTK21.02817749
49NEK11.02615423
50RIPK41.00261520
51MAP3K120.98463809
52MAPKAPK30.98399021
53MAP3K60.97959625
54LIMK10.97891320
55WNK40.97126675
56CAMK10.95723149
57UHMK10.95011680
58MAP3K130.94706745
59RPS6KA20.94395502
60STK110.93852715
61MAP3K70.92588191
62EPHA20.91563021
63OXSR10.90230774
64PRKCG0.89708967
65DAPK10.89156169
66CDK190.88533471
67CAMK1G0.87046440
68PDPK10.86306563
69MUSK0.86097901
70MAP3K10.85833739
71SGK20.83807529
72MARK20.83631701
73MAP3K110.82712059
74PDGFRA0.82688364
75SIK20.81923111
76CAMK2A0.81140001
77PRPF4B0.79164131
78CDC42BPA0.79127375
79PDK10.78504454
80TNK20.76585178
81DAPK30.75129647
82NEK60.74714456
83TTN0.73775652
84MAPK130.71984109
85FER0.70580510
86ALK0.70527689
87MAP2K30.69761048
88PTK2B0.69685408
89CDK150.69341630
90PDK30.69302975
91PDK40.69302975
92CDK180.68011283
93CDK140.67619337
94CAMK2D0.66473078
95PLK20.65227453
96MAPK70.64536343
97SMG10.64533303
98FES0.64299885
99PKN20.64294265
100TNIK0.62718756
101SGK10.61238224
102MAPK100.59796983
103STK390.59183378
104CDK11A0.57574718
105CAMK2B0.57461351
106CAMK40.57270168
107MAP3K30.56872143
108MTOR0.56735965
109PRKD10.56065052
110MAP2K10.55000966
111INSRR0.54802088
112RAF10.54434988
113DDR20.54348145
114FGFR40.54188009
115CAMK2G0.53587600
116RPS6KA30.52314434
117PAK20.52128393
118PKN10.52067248
119ROCK10.51863848
120MAPK40.50003350
121PRKG20.49881762
122PRKCZ0.48347723
123PTK60.48248434
124PRKAA10.47519820
125MET0.46974914
126WNK30.46884172
127PNCK0.46585342
128MAP2K60.46574270
129ICK0.45670538
130FGFR20.45520398
131PRKD20.44783157
132DYRK1B0.44644846
133PIK3CA0.44432597
134PRKCE0.44212030
135ROCK20.43200478

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.78073883
2Nicotine addiction_Homo sapiens_hsa050332.41364697
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30097503
4Olfactory transduction_Homo sapiens_hsa047402.27863530
5Circadian entrainment_Homo sapiens_hsa047132.21347955
6GABAergic synapse_Homo sapiens_hsa047272.19899857
7Nitrogen metabolism_Homo sapiens_hsa009102.10072642
8Long-term potentiation_Homo sapiens_hsa047202.06474765
9Insulin secretion_Homo sapiens_hsa049112.03625373
10Glutamatergic synapse_Homo sapiens_hsa047242.02516797
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98802019
12Morphine addiction_Homo sapiens_hsa050321.89620017
13Amphetamine addiction_Homo sapiens_hsa050311.88314393
14Salivary secretion_Homo sapiens_hsa049701.88311101
15Gastric acid secretion_Homo sapiens_hsa049711.84481075
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77051466
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73113758
18Dopaminergic synapse_Homo sapiens_hsa047281.71562429
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69805220
20Cholinergic synapse_Homo sapiens_hsa047251.64564500
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58257279
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52745794
23Oxytocin signaling pathway_Homo sapiens_hsa049211.46933016
24Renin secretion_Homo sapiens_hsa049241.45856015
25Type II diabetes mellitus_Homo sapiens_hsa049301.38512629
26Cocaine addiction_Homo sapiens_hsa050301.36165437
27GnRH signaling pathway_Homo sapiens_hsa049121.34482619
28Taste transduction_Homo sapiens_hsa047421.33097571
29Calcium signaling pathway_Homo sapiens_hsa040201.32850478
30Dilated cardiomyopathy_Homo sapiens_hsa054141.29630254
31Long-term depression_Homo sapiens_hsa047301.27549899
32Cardiac muscle contraction_Homo sapiens_hsa042601.25334411
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18558295
34Gap junction_Homo sapiens_hsa045401.18251644
35cAMP signaling pathway_Homo sapiens_hsa040241.18036432
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16333018
37Serotonergic synapse_Homo sapiens_hsa047261.12929298
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09514452
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07343113
40Focal adhesion_Homo sapiens_hsa045101.07284134
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06388594
42Estrogen signaling pathway_Homo sapiens_hsa049151.05584795
43Glioma_Homo sapiens_hsa052141.02334321
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98108564
45Dorso-ventral axis formation_Homo sapiens_hsa043200.97395716
46Collecting duct acid secretion_Homo sapiens_hsa049660.97060399
47ECM-receptor interaction_Homo sapiens_hsa045120.97052752
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94901375
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93869575
50Bile secretion_Homo sapiens_hsa049760.93752178
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91234578
52Pancreatic secretion_Homo sapiens_hsa049720.90683664
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90317803
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90088061
55Melanogenesis_Homo sapiens_hsa049160.89685977
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87492467
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85499083
58ErbB signaling pathway_Homo sapiens_hsa040120.85021451
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.83216849
60Axon guidance_Homo sapiens_hsa043600.79734994
61Glucagon signaling pathway_Homo sapiens_hsa049220.79609182
62Amoebiasis_Homo sapiens_hsa051460.78415261
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73966540
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70128888
65Arginine biosynthesis_Homo sapiens_hsa002200.70098107
66Insulin signaling pathway_Homo sapiens_hsa049100.68445573
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67744768
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67479293
69Vibrio cholerae infection_Homo sapiens_hsa051100.67059246
70Butanoate metabolism_Homo sapiens_hsa006500.66607623
71mTOR signaling pathway_Homo sapiens_hsa041500.66046696
72Notch signaling pathway_Homo sapiens_hsa043300.65727809
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.65400762
74Choline metabolism in cancer_Homo sapiens_hsa052310.63971327
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63639706
76VEGF signaling pathway_Homo sapiens_hsa043700.62218123
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62119078
78Circadian rhythm_Homo sapiens_hsa047100.62072931
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60913647
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.60011295
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.59695576
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59636875
83PPAR signaling pathway_Homo sapiens_hsa033200.58268260
84MAPK signaling pathway_Homo sapiens_hsa040100.57756252
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57273166
86Phototransduction_Homo sapiens_hsa047440.56828482
87Proteoglycans in cancer_Homo sapiens_hsa052050.55689113
88Endocytosis_Homo sapiens_hsa041440.55565691
89Platelet activation_Homo sapiens_hsa046110.54413422
90Arginine and proline metabolism_Homo sapiens_hsa003300.54304095
91Fatty acid biosynthesis_Homo sapiens_hsa000610.53464659
92Phenylalanine metabolism_Homo sapiens_hsa003600.52510251
93Inositol phosphate metabolism_Homo sapiens_hsa005620.52213150
94Histidine metabolism_Homo sapiens_hsa003400.51954606
95Oocyte meiosis_Homo sapiens_hsa041140.51451403
96Rap1 signaling pathway_Homo sapiens_hsa040150.48919669
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.47790602
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47083062
99Insulin resistance_Homo sapiens_hsa049310.46803907
100Renal cell carcinoma_Homo sapiens_hsa052110.46245962
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45960388
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44979236
103Ras signaling pathway_Homo sapiens_hsa040140.44855473
104Endometrial cancer_Homo sapiens_hsa052130.44482462
105Ovarian steroidogenesis_Homo sapiens_hsa049130.43647258
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.42381876
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41914672
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.41025043
109AMPK signaling pathway_Homo sapiens_hsa041520.39766381
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38846317
111Fatty acid metabolism_Homo sapiens_hsa012120.38733523
112Non-small cell lung cancer_Homo sapiens_hsa052230.38141472
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37674984
114Prion diseases_Homo sapiens_hsa050200.36824720
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.35566527
116Tight junction_Homo sapiens_hsa045300.35414809
117Propanoate metabolism_Homo sapiens_hsa006400.33417220

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