TOMM20L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.46497283
2motile cilium assembly (GO:0044458)9.46282368
3acrosome assembly (GO:0001675)9.19545918
4acrosome reaction (GO:0007340)9.15487351
5sperm-egg recognition (GO:0035036)9.02174909
6multicellular organism reproduction (GO:0032504)8.69519452
7cilium movement (GO:0003341)8.25949267
8binding of sperm to zona pellucida (GO:0007339)8.17903318
9plasma membrane fusion (GO:0045026)8.15474458
10cell-cell recognition (GO:0009988)7.96238908
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.83348709
12spermatid development (GO:0007286)7.70624048
13regulation of cilium movement (GO:0003352)7.61419577
14reproduction (GO:0000003)7.18909243
15piRNA metabolic process (GO:0034587)7.06909253
16ribosomal small subunit biogenesis (GO:0042274)6.13877405
17male meiosis (GO:0007140)6.09604518
18chaperone-mediated protein transport (GO:0072321)6.04461676
19single fertilization (GO:0007338)6.01199921
20synaptonemal complex organization (GO:0070193)5.71276375
21sperm capacitation (GO:0048240)5.45755669
22synaptonemal complex assembly (GO:0007130)5.39394075
23negative regulation of inclusion body assembly (GO:0090084)5.30025797
24microtubule depolymerization (GO:0007019)5.22236346
25rRNA methylation (GO:0031167)5.21166680
26DNA methylation involved in gamete generation (GO:0043046)5.18389983
27ventricular system development (GO:0021591)5.13738119
28rRNA modification (GO:0000154)5.10068155
29male meiosis I (GO:0007141)5.09919693
30DNA ligation (GO:0006266)5.00847113
31calcium ion-dependent exocytosis (GO:0017156)4.98043740
32GTP biosynthetic process (GO:0006183)4.96712044
33fertilization (GO:0009566)4.95545516
34spermatogenesis (GO:0007283)4.94945894
35viral transcription (GO:0019083)4.94605299
36male gamete generation (GO:0048232)4.93606323
37spermatid nucleus differentiation (GO:0007289)4.80176342
38translational termination (GO:0006415)4.79112591
39nucleoside diphosphate phosphorylation (GO:0006165)4.64213055
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64117309
41ribosomal large subunit biogenesis (GO:0042273)4.60980030
42cotranslational protein targeting to membrane (GO:0006613)4.56962837
43gamete generation (GO:0007276)4.56313345
44regulation of inclusion body assembly (GO:0090083)4.55832096
45regulation of mitochondrial translation (GO:0070129)4.53665096
46protein targeting to ER (GO:0045047)4.50703058
47regulation of microtubule-based movement (GO:0060632)4.45992356
48centriole assembly (GO:0098534)4.43095008
49cell recognition (GO:0008037)4.41550554
50ribonucleoprotein complex biogenesis (GO:0022613)4.40376136
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38162502
52maturation of SSU-rRNA (GO:0030490)4.37059792
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.35849883
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.35849883
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35719721
56UTP biosynthetic process (GO:0006228)4.32922074
57left/right pattern formation (GO:0060972)4.31862379
58establishment of protein localization to endoplasmic reticulum (GO:0072599)4.31593260
59translational initiation (GO:0006413)4.28533804
60germ cell development (GO:0007281)4.25876406
61protein localization to cilium (GO:0061512)4.22770816
62protein localization to endoplasmic reticulum (GO:0070972)4.22169155
63translational elongation (GO:0006414)4.18922518
64formation of translation preinitiation complex (GO:0001731)4.18907713
65ribosome assembly (GO:0042255)4.18049621
66meiosis I (GO:0007127)4.17760907
67cellular process involved in reproduction in multicellular organism (GO:0022412)4.13733837
68organic cation transport (GO:0015695)4.09909344
69translation (GO:0006412)4.06554382
70RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)4.05661333
71cellular component biogenesis (GO:0044085)4.04181768
72microtubule severing (GO:0051013)4.02508578
73proteasome assembly (GO:0043248)3.99151906
74mitochondrial respiratory chain complex assembly (GO:0033108)3.97224345
75DNA replication checkpoint (GO:0000076)3.95033625
76chromosome organization involved in meiosis (GO:0070192)3.93740472
77ribosomal small subunit assembly (GO:0000028)3.91591531
78termination of RNA polymerase I transcription (GO:0006363)3.90710564
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.89967173
80protein complex biogenesis (GO:0070271)3.89616614
81mitochondrial RNA metabolic process (GO:0000959)3.88960858
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88939468
83ATP synthesis coupled proton transport (GO:0015986)3.88939468
84cullin deneddylation (GO:0010388)3.86509366
85protein deneddylation (GO:0000338)3.85901931
86intraciliary transport (GO:0042073)3.81031366
87ribosome biogenesis (GO:0042254)3.80696327
88UTP metabolic process (GO:0046051)3.77064963
89meiotic nuclear division (GO:0007126)3.76881914
90viral life cycle (GO:0019058)3.74249904
91transcription from mitochondrial promoter (GO:0006390)3.67803435
92guanosine-containing compound biosynthetic process (GO:1901070)3.67799461
93chaperone-mediated protein complex assembly (GO:0051131)3.65879852
94pteridine-containing compound biosynthetic process (GO:0042559)3.65554393
95DNA catabolic process, exonucleolytic (GO:0000738)3.65532705
96rRNA processing (GO:0006364)3.64571847
97cellular protein complex disassembly (GO:0043624)3.64462061
98peptidyl-histidine modification (GO:0018202)3.63791006
99somatic hypermutation of immunoglobulin genes (GO:0016446)3.63019476
100somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63019476
101rRNA metabolic process (GO:0016072)3.62331847
102multicellular organismal reproductive process (GO:0048609)3.54298181
103lactate metabolic process (GO:0006089)3.53309008
104protein targeting to mitochondrion (GO:0006626)3.52525436
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.51992879
106transcription from RNA polymerase I promoter (GO:0006360)3.50573766
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48524886
108mitochondrial respiratory chain complex I assembly (GO:0032981)3.48524886
109NADH dehydrogenase complex assembly (GO:0010257)3.48524886
110respiratory electron transport chain (GO:0022904)3.47620280
111pseudouridine synthesis (GO:0001522)3.43732653
112axoneme assembly (GO:0035082)3.43414468
113transcription initiation from RNA polymerase I promoter (GO:0006361)3.43206238
114electron transport chain (GO:0022900)3.42182087
115meiotic cell cycle (GO:0051321)3.37713986
116CTP metabolic process (GO:0046036)3.36124403
117CTP biosynthetic process (GO:0006241)3.36124403
118cilium organization (GO:0044782)3.34679768
119spliceosomal snRNP assembly (GO:0000387)3.34175745
120centriole replication (GO:0007099)3.31293395
121microtubule polymerization or depolymerization (GO:0031109)3.29847199
122cilium assembly (GO:0042384)3.29544601
123protein-cofactor linkage (GO:0018065)3.28205119
124cilium morphogenesis (GO:0060271)3.27774078
125galactose catabolic process (GO:0019388)3.24894597
126protein localization to mitochondrion (GO:0070585)3.21169230
127termination of RNA polymerase III transcription (GO:0006386)3.19425240
128transcription elongation from RNA polymerase III promoter (GO:0006385)3.19425240
129seminiferous tubule development (GO:0072520)3.19398203
130phosphate ion transmembrane transport (GO:0035435)3.16666839
131single strand break repair (GO:0000012)3.16193654
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14748340
133establishment of protein localization to mitochondrion (GO:0072655)3.14589259
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14209396
135kinetochore assembly (GO:0051382)3.13034197
136protein complex disassembly (GO:0043241)3.09584674
137nuclear-transcribed mRNA catabolic process (GO:0000956)3.08621983
138macromolecular complex disassembly (GO:0032984)3.06932705
139telomere maintenance via semi-conservative replication (GO:0032201)3.05822461
140protein targeting to membrane (GO:0006612)3.02423331
141folic acid-containing compound biosynthetic process (GO:0009396)3.02404376
142glycerol ether metabolic process (GO:0006662)3.02269449
143alditol metabolic process (GO:0019400)3.02232327
144intracellular protein transmembrane import (GO:0044743)3.01881775
145organelle disassembly (GO:1903008)3.01613117
146prenylation (GO:0097354)3.01142917
147protein prenylation (GO:0018342)3.01142917
148nucleotide transmembrane transport (GO:1901679)3.00606589
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00050935
150water-soluble vitamin biosynthetic process (GO:0042364)2.99427049
151microtubule-based movement (GO:0007018)2.99181278
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99125371
153ncRNA metabolic process (GO:0034660)2.97659029
154RNA phosphodiester bond hydrolysis (GO:0090501)2.94697644
155chromosome condensation (GO:0030261)2.94393693
156N-acetylglucosamine metabolic process (GO:0006044)2.93513638
157cellular component assembly involved in morphogenesis (GO:0010927)2.93364070
158ncRNA processing (GO:0034470)2.93334853
159amino acid activation (GO:0043038)2.92616317
160tRNA aminoacylation (GO:0043039)2.92616317
161DNA packaging (GO:0006323)2.92611611
162tRNA metabolic process (GO:0006399)2.92295054
163ether metabolic process (GO:0018904)2.92093714
164tRNA aminoacylation for protein translation (GO:0006418)2.92000977
165tRNA processing (GO:0008033)2.91258938
166respiratory chain complex IV assembly (GO:0008535)2.90617048
167DNA strand elongation involved in DNA replication (GO:0006271)2.90427427
168mRNA catabolic process (GO:0006402)2.90254729
169multicellular organismal development (GO:0007275)2.89701439
170ncRNA 3-end processing (GO:0043628)2.89203495
171protein polyglutamylation (GO:0018095)2.83003259
172glycerol metabolic process (GO:0006071)2.77885584
173pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72726876
174neuron cell-cell adhesion (GO:0007158)2.70994823
175protein refolding (GO:0042026)2.69334092
176pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.66462548
177establishment of protein localization to mitochondrial membrane (GO:0090151)2.65028119
178presynaptic membrane assembly (GO:0097105)2.63317398
179genitalia morphogenesis (GO:0035112)2.61149109
180purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58397211
181polyol catabolic process (GO:0046174)2.56723363
182nucleotide phosphorylation (GO:0046939)2.54031234
183short-term memory (GO:0007614)2.53327781
184regulation of protein kinase A signaling (GO:0010738)2.51743233
185purine nucleoside triphosphate biosynthetic process (GO:0009145)2.49884535
186RNA destabilization (GO:0050779)2.45940876
187nucleoside triphosphate biosynthetic process (GO:0009142)2.41073930
188protein localization to synapse (GO:0035418)2.40003715
189regulation of protein kinase C signaling (GO:0090036)2.39866290
190regulation of spindle checkpoint (GO:0090231)2.39414054
191protein complex localization (GO:0031503)2.38542058
192cilium or flagellum-dependent cell motility (GO:0001539)11.3666549
193fusion of sperm to egg plasma membrane (GO:0007342)10.6620511
194cell wall macromolecule catabolic process (GO:0016998)10.4877513
195cell wall macromolecule metabolic process (GO:0044036)10.4877513
196axonemal dynein complex assembly (GO:0070286)10.2240228
197sperm motility (GO:0030317)10.0656221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.20211450
2EZH2_22144423_ChIP-Seq_EOC_Human6.60465203
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.94776956
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88946635
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.34863750
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77304699
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.76964900
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.68079251
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53670359
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52413507
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.31217752
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.30998263
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22231636
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18905684
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.08193860
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02328322
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67755924
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64056538
19VDR_23849224_ChIP-Seq_CD4+_Human2.63255916
20ZNF274_21170338_ChIP-Seq_K562_Hela2.63118304
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49840873
22VDR_22108803_ChIP-Seq_LS180_Human2.49053581
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48654705
24TAF15_26573619_Chip-Seq_HEK293_Human2.48549733
25FOXP3_21729870_ChIP-Seq_TREG_Human2.47195452
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46234599
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43381406
28TTF2_22483619_ChIP-Seq_HELA_Human2.34002677
29XRN2_22483619_ChIP-Seq_HELA_Human2.33927304
30ELK1_19687146_ChIP-ChIP_HELA_Human2.29343056
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27132580
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.27002249
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24249280
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.22796115
35E2F7_22180533_ChIP-Seq_HELA_Human2.22601981
36CBX2_27304074_Chip-Seq_ESCs_Mouse2.17686950
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14692945
38PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11238111
39DCP1A_22483619_ChIP-Seq_HELA_Human2.10577458
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09292895
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03774925
42CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02642512
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97955150
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97844275
45REST_21632747_ChIP-Seq_MESCs_Mouse1.96040494
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96037358
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96032628
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94779154
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.94743540
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90233192
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88613708
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.78092646
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77914065
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77729644
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77494324
56RNF2_27304074_Chip-Seq_NSC_Mouse1.71079209
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69557995
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.69420047
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69040607
60GABP_19822575_ChIP-Seq_HepG2_Human1.68518744
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62428171
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56843125
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.53977472
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53845360
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.53711572
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51832507
67MYC_18940864_ChIP-ChIP_HL60_Human1.50359440
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49194000
69FUS_26573619_Chip-Seq_HEK293_Human1.48863109
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48435676
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48435542
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46074532
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45943848
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.45148082
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45027052
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42418802
77ER_23166858_ChIP-Seq_MCF-7_Human1.42312193
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42259753
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42259753
80GBX2_23144817_ChIP-Seq_PC3_Human1.41308459
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41017808
82KDM2B_26808549_Chip-Seq_REH_Human1.40750748
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40569449
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.39595570
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38554506
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.37316096
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37280337
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.35863544
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35289286
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35046373
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34429258
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.32447078
93P53_22387025_ChIP-Seq_ESCs_Mouse1.31475900
94WDR5_24793694_ChIP-Seq_LNCAP_Human1.31353023
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31125492
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30852819
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27022810
98ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25915284
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23481642
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22220572
101CBP_20019798_ChIP-Seq_JUKART_Human1.22220572
102P300_18555785_Chip-Seq_ESCs_Mouse1.21945909
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21669059
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.20766371
105STAT1_17558387_ChIP-Seq_HELA_Human1.20664147
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19248716
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19140431
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18108822
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17861543
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17315942
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17315636
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17104695
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.17068297
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.16250670
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15794037
116* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15777522
117KDM5A_27292631_Chip-Seq_BREAST_Human1.15743913
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15672194
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15129174
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13626747
121TFEB_21752829_ChIP-Seq_HELA_Human1.13192739
122KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12778987
123SMAD4_21799915_ChIP-Seq_A2780_Human1.11667598
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11573468
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10596152
126KLF4_18555785_Chip-Seq_ESCs_Mouse1.10540314
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.10269072
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10129874
129* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08429323
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08307460
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.07808527
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.07784668
133EZH2_27304074_Chip-Seq_ESCs_Mouse1.07179240
134* TP53_22573176_ChIP-Seq_HFKS_Human1.07128222
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.06538298
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06156442
137SOX2_18555785_Chip-Seq_ESCs_Mouse1.05977372
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05456092
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.05333758
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05197077
141GATA3_21867929_ChIP-Seq_CD8_Mouse1.04678962
142SOX17_20123909_ChIP-Seq_XEN_Mouse1.04221549
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03965522
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.03438343
145SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01396582
146SOX9_26525672_Chip-Seq_HEART_Mouse1.01195979
147P300_19829295_ChIP-Seq_ESCs_Human1.01052562
148TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00295685
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00105856
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.99799184
151RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98803695
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.97516968
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.97295924
154GATA3_21867929_ChIP-Seq_TH1_Mouse0.96404085
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.95956792
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95110574
157IRF1_19129219_ChIP-ChIP_H3396_Human0.94647154
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93167259
159ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93072093
160BCAT_22108803_ChIP-Seq_LS180_Human0.92915531
161GF1_26923725_Chip-Seq_HPCs_Mouse0.90668833
162EWS_26573619_Chip-Seq_HEK293_Human0.90335788
163SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89973229
164SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89970790
165PU1_27457419_Chip-Seq_LIVER_Mouse0.89903287
166BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89847294
167ZFX_18555785_Chip-Seq_ESCs_Mouse0.89240738
168CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89187273
169ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88773202
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87727960
171SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87058254
172RNF2_27304074_Chip-Seq_ESCs_Mouse0.86923977
173LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85810547
174SOX2_16153702_ChIP-ChIP_HESCs_Human0.85575521
175AR_21909140_ChIP-Seq_LNCAP_Human0.85177830
176* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84791982
177TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84181531
178CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82950273
179ERG_20517297_ChIP-Seq_VCAP_Human0.82543855
180CIITA_25753668_ChIP-Seq_RAJI_Human0.82224807
181NANOG_16153702_ChIP-ChIP_HESCs_Human0.81860703
182AR_20517297_ChIP-Seq_VCAP_Human0.78742613
183ELF5_23300383_ChIP-Seq_T47D_Human0.76637674
184KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76274760
185ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68272279
186ERA_21632823_ChIP-Seq_H3396_Human0.67823371
187FOXM1_23109430_ChIP-Seq_U2OS_Human0.67766555
188TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67409087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.49331147
2MP0001929_abnormal_gametogenesis3.97378728
3MP0008877_abnormal_DNA_methylation3.95751371
4MP0003880_abnormal_central_pattern3.64506345
5MP0004957_abnormal_blastocyst_morpholog3.18145709
6MP0002837_dystrophic_cardiac_calcinosis3.14391827
7MP0003786_premature_aging2.83957056
8MP0005379_endocrine/exocrine_gland_phen2.74885579
9MP0009780_abnormal_chondrocyte_physiolo2.71285914
10MP0008995_early_reproductive_senescence2.66789988
11MP0009046_muscle_twitch2.63262400
12MP0002210_abnormal_sex_determination2.58293901
13MP0003186_abnormal_redox_activity2.49525833
14MP0002161_abnormal_fertility/fecundity2.49171914
15MP0003806_abnormal_nucleotide_metabolis2.42945027
16MP0003693_abnormal_embryo_hatching2.37456205
17MP0003077_abnormal_cell_cycle2.30365344
18MP0001145_abnormal_male_reproductive2.20747162
19MP0002653_abnormal_ependyma_morphology2.12285188
20MP0009697_abnormal_copulation2.11456862
21MP0003136_yellow_coat_color2.06472325
22MP0006036_abnormal_mitochondrial_physio2.02953751
23MP0001764_abnormal_homeostasis2.01452590
24MP0008875_abnormal_xenobiotic_pharmacok2.00775113
25MP0005410_abnormal_fertilization10.9415738
26MP0000372_irregular_coat_pigmentation1.98754096
27MP0000653_abnormal_sex_gland1.93268436
28MP0001486_abnormal_startle_reflex1.91661320
29MP0005423_abnormal_somatic_nervous1.91611842
30MP0006276_abnormal_autonomic_nervous1.90455780
31MP0001873_stomach_inflammation1.89186495
32MP0001984_abnormal_olfaction1.83021575
33MP0010234_abnormal_vibrissa_follicle1.81788690
34MP0003111_abnormal_nucleus_morphology1.74005523
35MP0003635_abnormal_synaptic_transmissio1.72765702
36MP0001661_extended_life_span1.71870773
37MP0002160_abnormal_reproductive_system1.70541473
38MP0002009_preneoplasia1.66821402
39MP0004859_abnormal_synaptic_plasticity1.66582845
40MP0001968_abnormal_touch/_nociception1.59437800
41MP0004233_abnormal_muscle_weight1.59090143
42MP0004742_abnormal_vestibular_system1.58017690
43MP0002064_seizures1.57991394
44MP0002277_abnormal_respiratory_mucosa1.56746731
45MP0002102_abnormal_ear_morphology1.55426304
46MP0001440_abnormal_grooming_behavior1.55334993
47MP0002572_abnormal_emotion/affect_behav1.46529727
48MP0002272_abnormal_nervous_system1.46397340
49MP0009745_abnormal_behavioral_response1.44554350
50MP0005636_abnormal_mineral_homeostasis1.42667747
51MP0005408_hypopigmentation1.40550481
52MP0005310_abnormal_salivary_gland1.37007586
53MP0008872_abnormal_physiological_respon1.36605498
54MP0003937_abnormal_limbs/digits/tail_de1.35665016
55MP0004185_abnormal_adipocyte_glucose1.35298122
56MP0001348_abnormal_lacrimal_gland1.29854851
57MP0002796_impaired_skin_barrier1.28750412
58MP0005623_abnormal_meninges_morphology1.28526188
59MP0001188_hyperpigmentation1.28352022
60MP0001529_abnormal_vocalization1.26978845
61MP0002063_abnormal_learning/memory/cond1.25908270
62MP0003195_calcinosis1.22975221
63MP0003646_muscle_fatigue1.22061044
64MP0008260_abnormal_autophagy1.21732761
65MP0000778_abnormal_nervous_system1.20379467
66MP0005501_abnormal_skin_physiology1.19942048
67MP0004270_analgesia1.19175725
68MP0001501_abnormal_sleep_pattern1.18756522
69MP0002557_abnormal_social/conspecific_i1.17753938
70MP0000358_abnormal_cell_content/1.15290514
71MP0002736_abnormal_nociception_after1.15001169
72MP0002067_abnormal_sensory_capabilities1.14688648
73MP0010386_abnormal_urinary_bladder1.14445730
74MP0003567_abnormal_fetal_cardiomyocyte1.14188416
75MP0003122_maternal_imprinting1.13922119
76MP0005266_abnormal_metabolism1.13410097
77MP0006292_abnormal_olfactory_placode1.12781319
78MP0002282_abnormal_trachea_morphology1.12139382
79MP0005187_abnormal_penis_morphology1.10922984
80MP0003011_delayed_dark_adaptation1.10708787
81MP0002132_abnormal_respiratory_system1.10502009
82MP0005645_abnormal_hypothalamus_physiol1.07629449
83MP0006072_abnormal_retinal_apoptosis1.06974851
84MP0001881_abnormal_mammary_gland1.06381940
85MP0008007_abnormal_cellular_replicative1.06018131
86MP0005551_abnormal_eye_electrophysiolog1.04927365
87MP0002734_abnormal_mechanical_nocicepti1.03144835
88MP0005409_darkened_coat_color1.01162087
89MP0003283_abnormal_digestive_organ1.00401811
90MP0008058_abnormal_DNA_repair0.99873604
91MP0000751_myopathy0.96393690
92MP0008057_abnormal_DNA_replication0.96231668
93MP0001502_abnormal_circadian_rhythm0.95504025
94MP0001727_abnormal_embryo_implantation0.95182764
95MP0005220_abnormal_exocrine_pancreas0.94791869
96MP0003941_abnormal_skin_development0.94494132
97MP0009379_abnormal_foot_pigmentation0.93202361
98MP0004133_heterotaxia0.92766145
99MP0000350_abnormal_cell_proliferation0.91124514
100MP0004019_abnormal_vitamin_homeostasis0.90446309
101MP0005670_abnormal_white_adipose0.87656939
102MP0002184_abnormal_innervation0.87396365
103MP0001944_abnormal_pancreas_morphology0.85756597
104MP0002152_abnormal_brain_morphology0.85616132
105MP0008569_lethality_at_weaning0.85263860
106MP0003936_abnormal_reproductive_system0.85255512
107MP0009250_abnormal_appendicular_skeleto0.84779142
108MP0001970_abnormal_pain_threshold0.82670365
109MP0005167_abnormal_blood-brain_barrier0.82616362
110MP0002638_abnormal_pupillary_reflex0.82073935
111MP0001697_abnormal_embryo_size0.82069928
112MP0002938_white_spotting0.81711316
113MP0000313_abnormal_cell_death0.81423576
114MP0004142_abnormal_muscle_tone0.81039897
115MP0005389_reproductive_system_phenotype0.80157612
116MP0002234_abnormal_pharynx_morphology0.78485122
117MP0001905_abnormal_dopamine_level0.77454742
118MP0002882_abnormal_neuron_morphology0.76499076
119MP0003890_abnormal_embryonic-extraembry0.76342036
120MP0003315_abnormal_perineum_morphology0.75787417
121MP0005332_abnormal_amino_acid0.74247667
122MP0000026_abnormal_inner_ear0.74079470
123MP0003879_abnormal_hair_cell0.74025063
124MP0001765_abnormal_ion_homeostasis0.73882708
125MP0001963_abnormal_hearing_physiology0.73290561
126MP0002752_abnormal_somatic_nervous0.73246272
127MP0002733_abnormal_thermal_nociception0.73141772
128MP0002066_abnormal_motor_capabilities/c0.72706220
129MP0002822_catalepsy0.71845649
130MP0003861_abnormal_nervous_system0.71241462
131MP0003123_paternal_imprinting0.71081623
132MP0005174_abnormal_tail_pigmentation0.69890438
133MP0005253_abnormal_eye_physiology0.69579128
134MP0003938_abnormal_ear_development0.69161008
135MP0001485_abnormal_pinna_reflex0.69158994
136MP0003699_abnormal_female_reproductive0.69153474
137MP0010094_abnormal_chromosome_stability0.69004572
138MP0005075_abnormal_melanosome_morpholog0.68206073
139MP0005386_behavior/neurological_phenoty0.68191443
140MP0004924_abnormal_behavior0.68191443
141MP0002229_neurodegeneration0.67448610
142MP0001299_abnormal_eye_distance/0.67420785
143MP0002085_abnormal_embryonic_tissue0.67260480
144MP0002693_abnormal_pancreas_physiology0.67208315
145MP0001672_abnormal_embryogenesis/_devel0.66050838
146MP0005380_embryogenesis_phenotype0.66050838
147MP0001293_anophthalmia0.65903653
148MP0009384_cardiac_valve_regurgitation0.65207351
149MP0000462_abnormal_digestive_system0.64951363
150MP0002084_abnormal_developmental_patter0.64641442
151MP0001324_abnormal_eye_pigmentation0.63299734
152MP0005376_homeostasis/metabolism_phenot0.61470152
153MP0001986_abnormal_taste_sensitivity0.60186663
154MP0002088_abnormal_embryonic_growth/wei0.59701203
155MP0003984_embryonic_growth_retardation0.59637517
156MP0008932_abnormal_embryonic_tissue0.58796341
157MP0003329_amyloid_beta_deposits0.58055572
158MP0004145_abnormal_muscle_electrophysio0.57903788
159MP0000631_abnormal_neuroendocrine_gland0.56264875
160MP0004811_abnormal_neuron_physiology0.55756700
161MP0005377_hearing/vestibular/ear_phenot0.54437396
162MP0003878_abnormal_ear_physiology0.54437396
163MP0002163_abnormal_gland_morphology0.52851212
164MP0003718_maternal_effect0.52198224
165MP0005391_vision/eye_phenotype0.51988596
166MP0000955_abnormal_spinal_cord0.51015311
167MP0002177_abnormal_outer_ear0.50370462
168MP0006035_abnormal_mitochondrial_morpho0.50165773

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.79660909
2Abnormal respiratory epithelium morphology (HP:0012253)8.64711341
3Abnormal respiratory motile cilium morphology (HP:0005938)8.64711341
4Rhinitis (HP:0012384)7.52370278
5Abnormal ciliary motility (HP:0012262)7.21571005
6Chronic bronchitis (HP:0004469)6.99542583
7Fibular aplasia (HP:0002990)6.20336186
8Infertility (HP:0000789)5.49741841
9Increased hepatocellular lipid droplets (HP:0006565)5.34243389
10Lipid accumulation in hepatocytes (HP:0006561)4.68009510
11Nasal polyposis (HP:0100582)4.56255960
12Bronchiectasis (HP:0002110)4.22149241
13Renal Fanconi syndrome (HP:0001994)4.14010758
14Nephronophthisis (HP:0000090)4.05754646
15Increased intramyocellular lipid droplets (HP:0012240)3.69931594
16Adactyly (HP:0009776)3.68733238
17Abnormality of the nasal mucosa (HP:0000433)3.58784099
18Medial flaring of the eyebrow (HP:0010747)3.55378010
19Increased CSF lactate (HP:0002490)3.50028372
20Bronchitis (HP:0012387)3.40017561
21Respiratory difficulties (HP:0002880)3.31403707
22Tubulointerstitial nephritis (HP:0001970)3.30751562
23Birth length less than 3rd percentile (HP:0003561)3.24461172
24Exertional dyspnea (HP:0002875)3.23309473
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05715916
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.05339682
273-Methylglutaconic aciduria (HP:0003535)3.04892824
28Hypoplastic pelvis (HP:0008839)3.04499400
29Increased muscle lipid content (HP:0009058)3.04137366
30Humeroradial synostosis (HP:0003041)3.01383613
31Synostosis involving the elbow (HP:0003938)3.01383613
32Gait imbalance (HP:0002141)3.00763889
33Supernumerary spleens (HP:0009799)3.00526910
34Abnormality of the renal medulla (HP:0100957)2.98285603
35Increased serum lactate (HP:0002151)2.90952648
36Reticulocytopenia (HP:0001896)2.90096656
37Congenital primary aphakia (HP:0007707)2.89998083
38Hepatic necrosis (HP:0002605)2.89397387
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88987665
40Macrocytic anemia (HP:0001972)2.86316290
41Methylmalonic acidemia (HP:0002912)2.83866401
42Focal motor seizures (HP:0011153)2.76198708
43Abnormal number of erythroid precursors (HP:0012131)2.75631771
44Molar tooth sign on MRI (HP:0002419)2.74842747
45Abnormality of midbrain morphology (HP:0002418)2.74842747
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.71302213
47Abnormality of renal resorption (HP:0011038)2.68479273
48Abnormality of cells of the erythroid lineage (HP:0012130)2.67820809
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66490275
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66490275
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65466848
52Abnormality of alanine metabolism (HP:0010916)2.65466848
53Hyperalaninemia (HP:0003348)2.65466848
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64546198
55Hepatocellular necrosis (HP:0001404)2.63820774
56Type I transferrin isoform profile (HP:0003642)2.62093422
57Chromsome breakage (HP:0040012)2.61769381
58Recurrent otitis media (HP:0000403)2.59406164
59Glycosuria (HP:0003076)2.57789197
60Abnormality of urine glucose concentration (HP:0011016)2.57789197
61Nephrogenic diabetes insipidus (HP:0009806)2.54138940
62Methylmalonic aciduria (HP:0012120)2.49899864
63Tubulointerstitial abnormality (HP:0001969)2.47589055
64Recurrent sinusitis (HP:0011108)2.47281996
65Abnormal protein glycosylation (HP:0012346)2.46696758
66Abnormal glycosylation (HP:0012345)2.46696758
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46696758
68Abnormal protein N-linked glycosylation (HP:0012347)2.46696758
69Abnormality of methionine metabolism (HP:0010901)2.44549721
70Mesomelia (HP:0003027)2.42996855
71Vaginal atresia (HP:0000148)2.41559694
72Oligodactyly (hands) (HP:0001180)2.40635606
73Lactic acidosis (HP:0003128)2.38067439
74Double outlet right ventricle (HP:0001719)2.37335744
75Congenital malformation of the right heart (HP:0011723)2.37335744
76Genital tract atresia (HP:0001827)2.35841330
77Generalized aminoaciduria (HP:0002909)2.34099106
78Hyperphosphaturia (HP:0003109)2.26534119
79Abnormal spermatogenesis (HP:0008669)2.24348818
80Absent thumb (HP:0009777)2.21635715
81Carpal bone hypoplasia (HP:0001498)2.20475596
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19996041
83Poor coordination (HP:0002370)2.16674684
84Impulsivity (HP:0100710)2.16243005
85Exercise intolerance (HP:0003546)2.13981720
86Hypoglycemic coma (HP:0001325)2.13295229
87Amyotrophic lateral sclerosis (HP:0007354)2.12384894
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.12216273
89Meckel diverticulum (HP:0002245)2.11381364
90Cerebral edema (HP:0002181)2.07258150
91Short 1st metacarpal (HP:0010034)2.07188256
92Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07188256
93Abnormal rod and cone electroretinograms (HP:0008323)2.05470890
94Tubular atrophy (HP:0000092)2.04221830
95Lethargy (HP:0001254)2.04001013
96Renal tubular dysfunction (HP:0000124)2.03675585
97Male infertility (HP:0003251)2.03544115
98Respiratory failure (HP:0002878)2.02624802
99Acute necrotizing encephalopathy (HP:0006965)2.02212855
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0523306
101Absent/shortened dynein arms (HP:0200106)11.2727165
102Dynein arm defect of respiratory motile cilia (HP:0012255)11.2727165
103Stage 5 chronic kidney disease (HP:0003774)1.99966735
104Abnormality of the ileum (HP:0001549)1.98330618
105Enlarged epiphyses (HP:0010580)1.97323256
106Aplasia/Hypoplasia of the patella (HP:0006498)1.97113971
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94804988
108Megaloblastic anemia (HP:0001889)1.94418938
109Hypoalbuminemia (HP:0003073)1.94367739
110Abnormal albumin level (HP:0012116)1.94367739
111Aplasia/Hypoplasia of the lens (HP:0008063)1.94159853
112Abnormality of the preputium (HP:0100587)1.93096256
113Aplasia involving forearm bones (HP:0009822)1.93033841
114Absent forearm bone (HP:0003953)1.93033841
115Pancreatic fibrosis (HP:0100732)1.90948088
116Radial bowing (HP:0002986)1.90408233
117Constricted visual fields (HP:0001133)1.89242207
118Aplasia/Hypoplasia of the fibula (HP:0006492)1.87900966
119Optic disc pallor (HP:0000543)1.86607128
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86062480
121Ependymoma (HP:0002888)1.83732682
122Renal cortical cysts (HP:0000803)1.83314338
123Abnormal finger flexion creases (HP:0006143)1.82596240
124Abnormality of chromosome stability (HP:0003220)1.80543637
125Intestinal atresia (HP:0011100)1.80421891
126Abnormality of the 1st metacarpal (HP:0010009)1.78553761
127Pallor (HP:0000980)1.78399188
128Facial cleft (HP:0002006)1.77194302
129Chronic sinusitis (HP:0011109)1.75588805
130Tubulointerstitial fibrosis (HP:0005576)1.74616729
131True hermaphroditism (HP:0010459)1.74210781
132Azoospermia (HP:0000027)1.72762897
133Sensory axonal neuropathy (HP:0003390)1.72216492
134Retinal dysplasia (HP:0007973)1.67583125
135Postaxial foot polydactyly (HP:0001830)1.66848402
136Congenital hepatic fibrosis (HP:0002612)1.66649270
137Postaxial hand polydactyly (HP:0001162)1.64974612
138Abnormality of the lower motor neuron (HP:0002366)1.63704269
139Absent eyebrow (HP:0002223)1.62866967
140Fibular hypoplasia (HP:0003038)1.61876501
141Hyperventilation (HP:0002883)1.61864475
142Progressive macrocephaly (HP:0004481)1.61053033
143Abnormal mitochondria in muscle tissue (HP:0008316)1.59042820
144Gonadotropin excess (HP:0000837)1.58471718
145Oculomotor apraxia (HP:0000657)1.56718437
146Pancreatic cysts (HP:0001737)1.56012990
147Abnormality of the dental pulp (HP:0006479)1.55170931
148Bifid tongue (HP:0010297)1.53921944
149Short tibia (HP:0005736)1.53884174
150Atonic seizures (HP:0010819)1.53745142
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.51006245
152Median cleft lip (HP:0000161)1.48651848
153Progressive inability to walk (HP:0002505)1.48479118
154Focal seizures (HP:0007359)1.48370686
155Gaze-evoked nystagmus (HP:0000640)1.48003013
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.47977410
157Delayed gross motor development (HP:0002194)1.47353908
158Abnormality of permanent molar morphology (HP:0011071)1.46647760
159Abnormality of the dental root (HP:0006486)1.46647760
160Taurodontia (HP:0000679)1.46647760
161Specific learning disability (HP:0001328)1.46541644
162Inability to walk (HP:0002540)1.45587214
163Acute encephalopathy (HP:0006846)1.44365598
164Microglossia (HP:0000171)1.44213297
165Anencephaly (HP:0002323)1.42730143
166Dental crowding (HP:0000678)1.39163527
167Abnormality of dentin (HP:0010299)1.39056535
168Epileptic encephalopathy (HP:0200134)1.39055759
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.38530441
170Decreased central vision (HP:0007663)1.38290001
171Mitochondrial inheritance (HP:0001427)1.38218165
172Aganglionic megacolon (HP:0002251)1.36965275
173Dyschromatopsia (HP:0007641)1.35340545
174Sclerocornea (HP:0000647)1.34617506
175Polyphagia (HP:0002591)1.34240751
176Abnormality of the phalanges of the hallux (HP:0010057)1.33703606
177Abnormality of molar (HP:0011077)1.33552094
178Abnormality of molar morphology (HP:0011070)1.33552094
179Abnormal gallbladder physiology (HP:0012438)1.33444326
180Cholecystitis (HP:0001082)1.33444326
181Degeneration of the lateral corticospinal tracts (HP:0002314)1.32194168
182Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.32194168
183Poor suck (HP:0002033)1.31722241
184Hemiparesis (HP:0001269)1.29786602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.99002741
2PDK46.99002741
3PDK24.71811622
4PBK4.18444172
5CASK4.09216692
6TESK13.52872818
7PNCK3.36505077
8STK392.98434768
9EIF2AK12.89718075
10VRK22.46177556
11MAP3K22.46061599
12WNK42.32976934
13NUAK12.23328418
14EIF2AK32.22022088
15FRK2.21425347
16MST42.20357704
17PRKD32.10052604
18PTK2B1.99333035
19ICK1.91046530
20ZAK1.82389086
21PIM21.62271058
22NME21.61653671
23STK381.52604616
24PASK1.49017709
25AKT31.47177923
26VRK11.45638877
27GRK71.45370496
28WEE11.41916908
29MAP4K21.41880436
30GRK11.34503488
31TEC1.33337091
32RIPK41.31788424
33MAP3K31.30011310
34NEK21.28865851
35STK41.25542603
36PLK31.25406572
37WNK11.18934267
38PINK11.12417948
39PAK61.08798131
40STK241.07874125
41BLK1.06327546
42MAP3K121.02530674
43DAPK31.02046443
44MAPK151.00545768
45TNIK0.96337525
46ADRBK20.95860661
47BRSK20.93964514
48STK160.93373622
49TLK10.92868684
50MAP2K70.91473256
51NTRK20.90504479
52BCKDK0.89735639
53IRAK20.89449223
54ITK0.88498986
55CLK10.87743229
56CCNB10.87280940
57ILK0.86711966
58SCYL20.86695703
59NEK10.85060857
60BMPR1B0.84137028
61OBSCN0.82212043
62EPHA40.82048309
63TXK0.80335704
64BRSK10.78605199
65YES10.78448079
66AURKB0.78361363
67TSSK60.78303806
68DYRK1B0.77087258
69MAP3K40.76936180
70INSRR0.76712761
71BRAF0.76127350
72DYRK20.75392944
73NTRK30.74629871
74PRKCG0.74394843
75SIK20.71902262
76MOS0.71833402
77MAP3K100.70891954
78MKNK20.70796590
79CSNK1G10.70415102
80TTK0.70331896
81TAOK20.70044045
82DYRK30.69789107
83AURKA0.68616892
84CAMK2A0.68529792
85CHEK20.68449716
86RPS6KA50.68070886
87MAPK130.67574217
88BUB10.65389391
89LATS10.65001219
90PIK3CA0.63398294
91STK38L0.63287172
92PIM10.62443217
93MARK10.62382286
94CSNK1G30.62191140
95PDK10.60314370
96NME10.59588699
97BRD40.57411766
98TAOK30.57174515
99ALK0.56674596
100PAK10.55324597
101CDK190.54603716
102EIF2AK20.54063287
103RPS6KA60.53643651
104LATS20.53343295
105NEK60.52692145
106MINK10.52048103
107CSNK1E0.51810569
108MAP2K40.50788513
109MYLK0.50250745
110CAMK2G0.49187183
111ATM0.48576722
112UHMK10.48115577
113MAP3K50.47256163
114ABL20.46940136
115PRKAA20.45960630
116CDK30.45254421
117PLK20.45073105
118ERBB20.43364551
119PDPK10.43237141
120PLK40.42542383
121ATR0.42383741
122PHKG10.42148947
123PHKG20.42148947
124OXSR10.42018038
125BMPR20.41682745
126PKN10.40963587
127EPHA20.40808570
128STK30.40576535
129GRK50.40476191
130IRAK10.40440199
131PLK10.40347472
132CDK80.40274766
133CSNK1G20.38895613
134CDK50.38491128
135ACVR1B0.38025415
136PAK20.37476301
137MAP3K110.35591391
138CDC70.34109578
139CAMK1D0.34100833
140CDK140.33508208
141CDK180.32321627
142RAF10.32232512
143MUSK0.31696935
144FES0.31236893
145CDK150.30871201
146PRKG10.30842155
147ADRBK10.30366800
148CDK10.30071229
149FGFR20.30010934
150MAPKAPK50.29599972
151BCR0.27896161
152CAMK2B0.27480094
153CHEK10.26409932
154WNK30.26146067
155CDK11A0.25998634
156ERBB40.25894480
157PRKACA0.24347562
158CSNK2A20.24145353
159CSNK2A10.23126743
160MAP2K60.23078618
161MKNK10.23075421
162NTRK10.22329067
163ROCK20.22087592
164SRPK10.21916952

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.98171151
2Mismatch repair_Homo sapiens_hsa034303.40714090
3Huntingtons disease_Homo sapiens_hsa050163.32071995
4Oxidative phosphorylation_Homo sapiens_hsa001903.31122645
5Nicotine addiction_Homo sapiens_hsa050333.08063939
6DNA replication_Homo sapiens_hsa030302.83704467
7Basal transcription factors_Homo sapiens_hsa030222.60058717
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52184836
9Parkinsons disease_Homo sapiens_hsa050122.51568687
10Cardiac muscle contraction_Homo sapiens_hsa042602.43646736
11Pyruvate metabolism_Homo sapiens_hsa006202.38365411
12Amphetamine addiction_Homo sapiens_hsa050312.34289751
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.32210156
14One carbon pool by folate_Homo sapiens_hsa006702.21431825
15Alzheimers disease_Homo sapiens_hsa050102.20644676
16Collecting duct acid secretion_Homo sapiens_hsa049662.17721214
17Synaptic vesicle cycle_Homo sapiens_hsa047212.02840615
18Oocyte meiosis_Homo sapiens_hsa041141.93528947
19RNA degradation_Homo sapiens_hsa030181.80032784
20Base excision repair_Homo sapiens_hsa034101.75203504
21Folate biosynthesis_Homo sapiens_hsa007901.73169100
22Fanconi anemia pathway_Homo sapiens_hsa034601.71785000
23Glucagon signaling pathway_Homo sapiens_hsa049221.71486576
24Propanoate metabolism_Homo sapiens_hsa006401.68399639
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64030292
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59939811
27Non-homologous end-joining_Homo sapiens_hsa034501.58250710
28Linoleic acid metabolism_Homo sapiens_hsa005911.57573222
29Proteasome_Homo sapiens_hsa030501.51490681
30Long-term potentiation_Homo sapiens_hsa047201.51356321
31Ether lipid metabolism_Homo sapiens_hsa005651.47816337
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44646583
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42794961
34Purine metabolism_Homo sapiens_hsa002301.42102038
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.41296180
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.40201597
37Taste transduction_Homo sapiens_hsa047421.37902843
38Ribosome_Homo sapiens_hsa030101.34500193
39Renin secretion_Homo sapiens_hsa049241.34203740
40Glutamatergic synapse_Homo sapiens_hsa047241.34096735
41Fatty acid biosynthesis_Homo sapiens_hsa000611.32646256
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30197780
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.27007675
44RNA transport_Homo sapiens_hsa030131.20994874
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19379080
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18088286
47Dopaminergic synapse_Homo sapiens_hsa047281.17337329
48Pentose phosphate pathway_Homo sapiens_hsa000301.16591787
49Fatty acid elongation_Homo sapiens_hsa000621.15345070
50Calcium signaling pathway_Homo sapiens_hsa040201.14170710
51Salivary secretion_Homo sapiens_hsa049701.12162050
52Steroid biosynthesis_Homo sapiens_hsa001001.11575903
53Morphine addiction_Homo sapiens_hsa050321.11061035
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09618133
55Pyrimidine metabolism_Homo sapiens_hsa002401.09287486
56Cocaine addiction_Homo sapiens_hsa050301.06544833
57Dorso-ventral axis formation_Homo sapiens_hsa043201.05904920
58Insulin secretion_Homo sapiens_hsa049111.02680833
59GABAergic synapse_Homo sapiens_hsa047270.99484755
60mRNA surveillance pathway_Homo sapiens_hsa030150.99226579
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98030395
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.96750237
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95278775
64Circadian entrainment_Homo sapiens_hsa047130.94298865
65Glycerolipid metabolism_Homo sapiens_hsa005610.90319329
66Cell cycle_Homo sapiens_hsa041100.89408626
67Spliceosome_Homo sapiens_hsa030400.88502353
68Serotonergic synapse_Homo sapiens_hsa047260.87188359
69Fatty acid degradation_Homo sapiens_hsa000710.86217858
70Carbon metabolism_Homo sapiens_hsa012000.86184015
71Peroxisome_Homo sapiens_hsa041460.83865764
72Regulation of autophagy_Homo sapiens_hsa041400.83745930
73Selenocompound metabolism_Homo sapiens_hsa004500.83719394
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82369089
75Vibrio cholerae infection_Homo sapiens_hsa051100.82153431
76Phototransduction_Homo sapiens_hsa047440.80802201
77RNA polymerase_Homo sapiens_hsa030200.79573805
78Tryptophan metabolism_Homo sapiens_hsa003800.77973565
79Arachidonic acid metabolism_Homo sapiens_hsa005900.77599861
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77328285
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76471228
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.72684794
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71962327
84Estrogen signaling pathway_Homo sapiens_hsa049150.70039172
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69339350
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68164757
87Butanoate metabolism_Homo sapiens_hsa006500.68146968
88Vitamin digestion and absorption_Homo sapiens_hsa049770.67840897
89Metabolic pathways_Homo sapiens_hsa011000.66923669
90Olfactory transduction_Homo sapiens_hsa047400.66919877
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65823878
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65412163
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64793342
94Hedgehog signaling pathway_Homo sapiens_hsa043400.64488137
95p53 signaling pathway_Homo sapiens_hsa041150.63144678
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62942892
97Axon guidance_Homo sapiens_hsa043600.62930644
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62811022
99Wnt signaling pathway_Homo sapiens_hsa043100.62425793
100Galactose metabolism_Homo sapiens_hsa000520.62137711
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61999289
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61441333
103Fatty acid metabolism_Homo sapiens_hsa012120.59854657
104Mineral absorption_Homo sapiens_hsa049780.59364036
105Chemical carcinogenesis_Homo sapiens_hsa052040.58724911
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57949011
107Gastric acid secretion_Homo sapiens_hsa049710.57765316
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56315569
109Sulfur metabolism_Homo sapiens_hsa009200.55972215
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55378233
111Fat digestion and absorption_Homo sapiens_hsa049750.53148880
112N-Glycan biosynthesis_Homo sapiens_hsa005100.52735585
113Glutathione metabolism_Homo sapiens_hsa004800.52343822
114Long-term depression_Homo sapiens_hsa047300.51723879
115Fructose and mannose metabolism_Homo sapiens_hsa000510.50237419
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49644112
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48541453
118Retinol metabolism_Homo sapiens_hsa008300.48489223
119Alcoholism_Homo sapiens_hsa050340.48329868
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47033579
121Biosynthesis of amino acids_Homo sapiens_hsa012300.47001148
122Pancreatic secretion_Homo sapiens_hsa049720.46540058
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46139710
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44190111
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44183809
126Sphingolipid metabolism_Homo sapiens_hsa006000.44050629
127Oxytocin signaling pathway_Homo sapiens_hsa049210.43997596
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43619324
129Homologous recombination_Homo sapiens_hsa034400.42850886
130Thyroid hormone synthesis_Homo sapiens_hsa049180.42593008
131cAMP signaling pathway_Homo sapiens_hsa040240.41257180
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40767210
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40003357
134Protein export_Homo sapiens_hsa030600.39947869
135Asthma_Homo sapiens_hsa053100.39910165
136Melanogenesis_Homo sapiens_hsa049160.39439244
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39284194
138beta-Alanine metabolism_Homo sapiens_hsa004100.38844541
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.37706364
140Phenylalanine metabolism_Homo sapiens_hsa003600.36311027
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35805146
142Cholinergic synapse_Homo sapiens_hsa047250.34927303
143Nucleotide excision repair_Homo sapiens_hsa034200.32149658
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.30643049
145Caffeine metabolism_Homo sapiens_hsa002320.30240772
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.28798020
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.25565498
148TGF-beta signaling pathway_Homo sapiens_hsa043500.25341161
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23741197
150Tyrosine metabolism_Homo sapiens_hsa003500.23368553
151Starch and sucrose metabolism_Homo sapiens_hsa005000.15105853
152Circadian rhythm_Homo sapiens_hsa047100.15035726
153Arginine and proline metabolism_Homo sapiens_hsa003300.12249547
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07459206

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