TOMM34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.49294854
2folic acid-containing compound biosynthetic process (GO:0009396)4.51924457
3establishment of viral latency (GO:0019043)4.28352555
4COPI coating of Golgi vesicle (GO:0048205)4.06787419
5Golgi transport vesicle coating (GO:0048200)4.06787419
6pteridine-containing compound biosynthetic process (GO:0042559)4.05356832
7telomere maintenance via semi-conservative replication (GO:0032201)3.98563084
8ribosome assembly (GO:0042255)3.97090814
9DNA deamination (GO:0045006)3.82794321
10DNA replication initiation (GO:0006270)3.82783038
11DNA strand elongation involved in DNA replication (GO:0006271)3.71126837
12telomere maintenance via recombination (GO:0000722)3.64726524
13ribosomal small subunit assembly (GO:0000028)3.58987852
14DNA strand elongation (GO:0022616)3.57576145
15negative regulation of ligase activity (GO:0051352)3.53987400
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53987400
17purine nucleotide salvage (GO:0032261)3.47960676
18regulation of mitochondrial translation (GO:0070129)3.42665747
19regulation of cellular amino acid metabolic process (GO:0006521)3.42230326
20DNA replication checkpoint (GO:0000076)3.35653161
21mitotic chromosome condensation (GO:0007076)3.35009720
22ribosome biogenesis (GO:0042254)3.34192997
23nucleobase-containing small molecule interconversion (GO:0015949)3.29976025
24positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26972933
25protein deneddylation (GO:0000338)3.23139540
26mitotic recombination (GO:0006312)3.21459213
27telomere maintenance via telomere lengthening (GO:0010833)3.17860625
28cullin deneddylation (GO:0010388)3.17296893
29guanosine-containing compound biosynthetic process (GO:1901070)3.15287707
30positive regulation of ligase activity (GO:0051351)3.13175065
31mitochondrial RNA metabolic process (GO:0000959)3.09694140
32IMP biosynthetic process (GO:0006188)3.09130093
33L-serine metabolic process (GO:0006563)3.05762697
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.05659506
35proline biosynthetic process (GO:0006561)3.05548627
36pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01468758
37histone H2A acetylation (GO:0043968)3.01205134
38regulation of ubiquitin-protein transferase activity (GO:0051438)2.99635764
39nuclear envelope reassembly (GO:0031468)2.99303402
40mitotic nuclear envelope reassembly (GO:0007084)2.99303402
41CENP-A containing nucleosome assembly (GO:0034080)2.99070959
42mitotic sister chromatid segregation (GO:0000070)2.97015624
43somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96780114
44somatic hypermutation of immunoglobulin genes (GO:0016446)2.96780114
45chromatin remodeling at centromere (GO:0031055)2.96232120
46peptidyl-arginine omega-N-methylation (GO:0035247)2.92610132
47sequestering of actin monomers (GO:0042989)2.92225790
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91147365
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91147365
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90633138
51maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90144392
52transcription-coupled nucleotide-excision repair (GO:0006283)2.89949105
53pseudouridine synthesis (GO:0001522)2.89669446
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89497457
55regulation of ligase activity (GO:0051340)2.89178566
56maturation of 5.8S rRNA (GO:0000460)2.86960671
57mitotic metaphase plate congression (GO:0007080)2.83734840
58tetrahydrofolate metabolic process (GO:0046653)2.82679747
59nucleobase biosynthetic process (GO:0046112)2.80420567
60GMP metabolic process (GO:0046037)2.80171905
61pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77889600
62DNA ligation (GO:0006266)2.77838921
63tRNA aminoacylation for protein translation (GO:0006418)2.77621770
64regulation of meiosis I (GO:0060631)2.77530774
65piRNA metabolic process (GO:0034587)2.76404642
66postreplication repair (GO:0006301)2.76173188
677-methylguanosine mRNA capping (GO:0006370)2.76159797
68telomere maintenance (GO:0000723)2.75902726
69telomere organization (GO:0032200)2.75871462
70purine nucleobase biosynthetic process (GO:0009113)2.75288266
71folic acid-containing compound metabolic process (GO:0006760)2.73992151
72pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73729188
73UTP biosynthetic process (GO:0006228)2.73051656
74intra-S DNA damage checkpoint (GO:0031573)2.73038525
75desmosome organization (GO:0002934)2.72923809
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.71595130
777-methylguanosine RNA capping (GO:0009452)2.71407170
78RNA capping (GO:0036260)2.71407170
79establishment of protein localization to mitochondrial membrane (GO:0090151)2.70764307
80chromosome condensation (GO:0030261)2.70617704
81pteridine-containing compound metabolic process (GO:0042558)2.70447497
82maturation of SSU-rRNA (GO:0030490)2.70320940
83protein retention in ER lumen (GO:0006621)2.69816097
84nucleotide salvage (GO:0043173)2.69399701
85amino acid activation (GO:0043038)2.69042933
86tRNA aminoacylation (GO:0043039)2.69042933
87regulation of spindle organization (GO:0090224)2.69036758
88regulation of translational fidelity (GO:0006450)2.66474333
89proteasome assembly (GO:0043248)2.66189602
90DNA synthesis involved in DNA repair (GO:0000731)2.64860171
91CTP metabolic process (GO:0046036)2.64774819
92CTP biosynthetic process (GO:0006241)2.64774819
93establishment of chromosome localization (GO:0051303)2.64663318
94rRNA modification (GO:0000154)2.63379752
95regulation of translational termination (GO:0006449)2.63250178
96IMP metabolic process (GO:0046040)2.63152966
97negative regulation of meiosis (GO:0045835)2.62717528
98regulation of mitotic spindle organization (GO:0060236)2.62696657
99spliceosomal snRNP assembly (GO:0000387)2.62407083
100formation of translation preinitiation complex (GO:0001731)2.62149872
101mitotic nuclear envelope disassembly (GO:0007077)2.61908759
102inner mitochondrial membrane organization (GO:0007007)2.61779259
103base-excision repair (GO:0006284)2.61604371
104GTP biosynthetic process (GO:0006183)2.60309838
105meiotic chromosome segregation (GO:0045132)2.59871930
106G1/S transition of mitotic cell cycle (GO:0000082)2.59803085
107cell cycle G1/S phase transition (GO:0044843)2.59803085
108lipopolysaccharide biosynthetic process (GO:0009103)2.58729258
109nucleoside salvage (GO:0043174)2.57779342
110ribonucleoprotein complex biogenesis (GO:0022613)2.57670831
111regulation of cellular amine metabolic process (GO:0033238)2.55566922
112replication fork processing (GO:0031297)2.55341444
113transcription elongation from RNA polymerase III promoter (GO:0006385)2.55155618
114termination of RNA polymerase III transcription (GO:0006386)2.55155618
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54996123
116regulation of mitotic spindle checkpoint (GO:1903504)2.54996123
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54293969
118metaphase plate congression (GO:0051310)2.54199136
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54007569
120DNA replication-independent nucleosome organization (GO:0034724)2.53380304
121DNA replication-independent nucleosome assembly (GO:0006336)2.53380304
122attachment of spindle microtubules to kinetochore (GO:0008608)2.51386437
123nuclear pore organization (GO:0006999)2.51081616
124nuclear pore complex assembly (GO:0051292)2.50898230
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50413727
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49924679
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49043535
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49043535
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49043535
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48973398
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48973398
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.46428053
133viral mRNA export from host cell nucleus (GO:0046784)2.44766317
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44695158
135deoxyribose phosphate biosynthetic process (GO:0046385)2.44131504
1362-deoxyribonucleotide biosynthetic process (GO:0009265)2.44131504
137histone exchange (GO:0043486)2.43923846
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43725839
139nuclear envelope disassembly (GO:0051081)2.41637148
140membrane disassembly (GO:0030397)2.41637148
141positive regulation of gamma-delta T cell activation (GO:0046645)2.41137974
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.39813988
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.39813988
144DNA unwinding involved in DNA replication (GO:0006268)2.39419368
145rRNA methylation (GO:0031167)2.39007017
146signal transduction involved in cell cycle checkpoint (GO:0072395)2.37660113
147mismatch repair (GO:0006298)2.36955803
148establishment of integrated proviral latency (GO:0075713)2.36862433
149transcription from RNA polymerase I promoter (GO:0006360)2.36706962
150transcription elongation from RNA polymerase II promoter (GO:0006368)2.34592379
151regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.34503182
152deoxyribonucleotide biosynthetic process (GO:0009263)2.34403121
153RNA-dependent DNA replication (GO:0006278)2.33911474
154kinetochore organization (GO:0051383)2.32263987
155DNA methylation involved in gamete generation (GO:0043046)2.31291338
156translesion synthesis (GO:0019985)2.30278626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97087965
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.24237983
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.10766734
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.06092995
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05771659
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97396524
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95443393
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84103377
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80717162
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73257460
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62666426
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56627755
13VDR_23849224_ChIP-Seq_CD4+_Human2.50833689
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48347502
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47455422
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40182836
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39903757
18AR_21909140_ChIP-Seq_LNCAP_Human2.36993371
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33320427
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31552879
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23659247
22FOXP3_21729870_ChIP-Seq_TREG_Human2.22196843
23ZNF263_19887448_ChIP-Seq_K562_Human2.18307416
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18226961
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.14088737
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13597531
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.11383984
28* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04080933
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03348289
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02516743
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01659481
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01181702
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00790938
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99230856
35XRN2_22483619_ChIP-Seq_HELA_Human1.96600003
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95707669
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95068081
38* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93264062
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.92366715
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90881534
41CIITA_25753668_ChIP-Seq_RAJI_Human1.89109927
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88405621
43GABP_19822575_ChIP-Seq_HepG2_Human1.88305839
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.85809525
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82893528
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80143967
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78487707
48MYC_22102868_ChIP-Seq_BL_Human1.76988926
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76940074
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.72447762
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72328807
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.68882777
53DCP1A_22483619_ChIP-Seq_HELA_Human1.67083670
54ELK1_19687146_ChIP-ChIP_HELA_Human1.65612357
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.64376670
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63352785
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62544729
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59758666
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58885265
60TTF2_22483619_ChIP-Seq_HELA_Human1.58256341
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57215686
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56892803
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52003404
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51181961
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48826668
66SPI1_23547873_ChIP-Seq_NB4_Human1.48333402
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45500090
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44725819
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39173818
70TFEB_21752829_ChIP-Seq_HELA_Human1.37236338
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37145904
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33238039
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.33025931
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32999068
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31787238
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30844993
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29637832
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28733491
79TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28214937
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27368512
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27082806
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26805495
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25552502
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23294144
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22103638
86KDM5A_27292631_Chip-Seq_BREAST_Human1.20902266
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20650132
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18451472
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16287180
90* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16259464
91MYB_26560356_Chip-Seq_TH2_Human1.14962654
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14772222
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12568752
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11539422
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11511652
96MYC_18940864_ChIP-ChIP_HL60_Human1.10968133
97* ATF3_27146783_Chip-Seq_COLON_Human1.10524395
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08391676
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.08231494
100MYB_26560356_Chip-Seq_TH1_Human1.07506041
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05337034
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04520516
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03559238
104* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03385015
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01999825
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01857650
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01069925
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01014963
109TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00454700
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00140708
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99582225
112SCL_19346495_ChIP-Seq_HPC-7_Human0.99505567
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98585940
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98368549
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97803506
116VDR_21846776_ChIP-Seq_THP-1_Human0.97640490
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.97377252
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96786175
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95805896
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95036782
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.92345585
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92013150
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88820381
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87398639
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87242609
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87004521
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86328209
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86267897
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85985285
130FOXP1_21924763_ChIP-Seq_HESCs_Human0.85297947
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83687847
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.79861201
133MAF_26560356_Chip-Seq_TH1_Human0.79696497
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79134560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.90573893
2MP0003693_abnormal_embryo_hatching3.50305817
3MP0010094_abnormal_chromosome_stability3.38113514
4MP0003806_abnormal_nucleotide_metabolis3.30747859
5MP0008058_abnormal_DNA_repair3.09370536
6MP0002396_abnormal_hematopoietic_system2.97025445
7MP0008057_abnormal_DNA_replication2.86354529
8MP0008007_abnormal_cellular_replicative2.82331490
9MP0004957_abnormal_blastocyst_morpholog2.76706979
10MP0003077_abnormal_cell_cycle2.73131657
11MP0003763_abnormal_thymus_physiology2.61653110
12MP0003111_abnormal_nucleus_morphology2.54387847
13MP0010234_abnormal_vibrissa_follicle2.46394342
14MP0001835_abnormal_antigen_presentation2.39483606
15MP0001661_extended_life_span2.35821221
16MP0005671_abnormal_response_to2.35448305
17MP0003718_maternal_effect2.24590471
18MP0001986_abnormal_taste_sensitivity2.21021803
19MP0010030_abnormal_orbit_morphology2.19985518
20MP0009697_abnormal_copulation2.07795267
21MP0004808_abnormal_hematopoietic_stem2.03482459
22MP0003786_premature_aging2.00871301
23MP0003123_paternal_imprinting1.92408965
24MP0002398_abnormal_bone_marrow1.91798905
25MP0006292_abnormal_olfactory_placode1.78191668
26MP0009333_abnormal_splenocyte_physiolog1.77802555
27MP0002938_white_spotting1.77443186
28MP0009785_altered_susceptibility_to1.71280683
29MP0002132_abnormal_respiratory_system1.69026981
30MP0003787_abnormal_imprinting1.67682207
31MP0002420_abnormal_adaptive_immunity1.62764084
32MP0001800_abnormal_humoral_immune1.61336447
33MP0001545_abnormal_hematopoietic_system1.61266058
34MP0005397_hematopoietic_system_phenotyp1.61266058
35MP0001819_abnormal_immune_cell1.59991892
36MP0008932_abnormal_embryonic_tissue1.59893293
37MP0002163_abnormal_gland_morphology1.59306258
38MP0000015_abnormal_ear_pigmentation1.59147894
39MP0005075_abnormal_melanosome_morpholog1.57910647
40MP0000689_abnormal_spleen_morphology1.57145268
41MP0003950_abnormal_plasma_membrane1.55156923
42MP0003705_abnormal_hypodermis_morpholog1.53225662
43MP0000703_abnormal_thymus_morphology1.49982727
44MP0000716_abnormal_immune_system1.48816571
45MP0002452_abnormal_antigen_presenting1.47883548
46MP0002722_abnormal_immune_system1.47776521
47MP0002723_abnormal_immune_serum1.45191633
48MP0006036_abnormal_mitochondrial_physio1.44961396
49MP0006035_abnormal_mitochondrial_morpho1.44211624
50MP0000013_abnormal_adipose_tissue1.42835534
51MP0005623_abnormal_meninges_morphology1.42569379
52MP0005000_abnormal_immune_tolerance1.42492364
53MP0000685_abnormal_immune_system1.42332790
54MP0003121_genomic_imprinting1.41566561
55MP0002160_abnormal_reproductive_system1.40761180
56MP0004233_abnormal_muscle_weight1.39701901
57MP0000350_abnormal_cell_proliferation1.38682853
58MP0005408_hypopigmentation1.38351018
59MP0002210_abnormal_sex_determination1.38067743
60MP0010307_abnormal_tumor_latency1.37610231
61MP0002429_abnormal_blood_cell1.37059929
62MP0009780_abnormal_chondrocyte_physiolo1.34014841
63MP0000003_abnormal_adipose_tissue1.31619682
64MP0002019_abnormal_tumor_incidence1.30632966
65MP0002148_abnormal_hypersensitivity_rea1.30349727
66MP0000313_abnormal_cell_death1.27411381
67MP0000490_abnormal_crypts_of1.25814757
68MP0003941_abnormal_skin_development1.25551194
69MP0004272_abnormal_basement_membrane1.25126912
70MP0002405_respiratory_system_inflammati1.24703072
71MP0003566_abnormal_cell_adhesion1.24201053
72MP0000647_abnormal_sebaceous_gland1.23718147
73MP0005174_abnormal_tail_pigmentation1.21957998
74MP0001929_abnormal_gametogenesis1.20966730
75MP0010352_gastrointestinal_tract_polyps1.19518637
76MP0005501_abnormal_skin_physiology1.19462959
77MP0002060_abnormal_skin_morphology1.17527311
78MP0005165_increased_susceptibility_to1.16715659
79MP0001730_embryonic_growth_arrest1.14913738
80MP0003866_abnormal_defecation1.14863572
81MP0000678_abnormal_parathyroid_gland1.14439359
82MP0005367_renal/urinary_system_phenotyp1.13202278
83MP0000516_abnormal_urinary_system1.13202278
84MP0005025_abnormal_response_to1.12303666
85MP0002095_abnormal_skin_pigmentation1.11149993
86MP0002735_abnormal_chemical_nociception1.10961778
87MP0002006_tumorigenesis1.10755858
88MP0005670_abnormal_white_adipose1.10333844
89MP0005310_abnormal_salivary_gland1.09094826
90MP0005387_immune_system_phenotype1.09013311
91MP0001790_abnormal_immune_system1.09013311
92MP0005220_abnormal_exocrine_pancreas1.08708460
93MP0002653_abnormal_ependyma_morphology1.08276881
94MP0001764_abnormal_homeostasis1.07725312
95MP0001145_abnormal_male_reproductive1.07705785
96MP0002166_altered_tumor_susceptibility1.06281712
97MP0005464_abnormal_platelet_physiology1.05572805
98MP0002736_abnormal_nociception_after1.05093870
99MP0000858_altered_metastatic_potential1.04486194
100MP0005257_abnormal_intraocular_pressure1.04163605
101MP0000372_irregular_coat_pigmentation1.03656092
102MP0003984_embryonic_growth_retardation1.00845573
103MP0002085_abnormal_embryonic_tissue0.99356021
104MP0000762_abnormal_tongue_morphology0.98812674
105MP0005360_urolithiasis0.98363102
106MP0003943_abnormal_hepatobiliary_system0.98301447
107MP0008995_early_reproductive_senescence0.98195876
108MP0002419_abnormal_innate_immunity0.97169480
109MP0000653_abnormal_sex_gland0.97015035
110MP0008789_abnormal_olfactory_epithelium0.96063030
111MP0002084_abnormal_developmental_patter0.95530593
112MP0001119_abnormal_female_reproductive0.95059231
113MP0001188_hyperpigmentation0.94774715
114MP0005395_other_phenotype0.94591215
115MP0002877_abnormal_melanocyte_morpholog0.93528996
116MP0002088_abnormal_embryonic_growth/wei0.93265765
117MP0001873_stomach_inflammation0.92806925
118MP0010368_abnormal_lymphatic_system0.91912759
119MP0003942_abnormal_urinary_system0.91680820
120MP0000627_abnormal_mammary_gland0.91120690
121MP0005058_abnormal_lysosome_morphology0.90354220
122MP0005389_reproductive_system_phenotype0.89712436
123MP0000537_abnormal_urethra_morphology0.89450933
124MP0001944_abnormal_pancreas_morphology0.87820093
125MP0001968_abnormal_touch/_nociception0.86878817
126MP0001216_abnormal_epidermal_layer0.85777291
127MP0001881_abnormal_mammary_gland0.85515086
128MP0001853_heart_inflammation0.85182104
129MP0005023_abnormal_wound_healing0.84470005
130MP0005410_abnormal_fertilization0.84078651
131MP0008875_abnormal_xenobiotic_pharmacok0.84076725
132MP0003724_increased_susceptibility_to0.83755542
133MP0001727_abnormal_embryo_implantation0.82936608
134MP0005332_abnormal_amino_acid0.82769707
135MP0005330_cardiomyopathy0.82526628
136MP0005379_endocrine/exocrine_gland_phen0.82196127
137MP0002751_abnormal_autonomic_nervous0.80610559
138MP0001697_abnormal_embryo_size0.80494664
139MP0003436_decreased_susceptibility_to0.78091211
140MP0003879_abnormal_hair_cell0.77802594
141MP0001243_abnormal_dermal_layer0.77417561
142MP0003315_abnormal_perineum_morphology0.76700167
143MP0010771_integument_phenotype0.76640762
144MP0000613_abnormal_salivary_gland0.76127227
145MP0001529_abnormal_vocalization0.75946723
146MP0003698_abnormal_male_reproductive0.74805708
147MP0000534_abnormal_ureter_morphology0.74688481
148MP0003172_abnormal_lysosome_physiology0.74506654
149MP0003183_abnormal_peptide_metabolism0.74389737
150MP0002086_abnormal_extraembryonic_tissu0.74040762
151MP0003186_abnormal_redox_activity0.72208875
152MP0002177_abnormal_outer_ear0.72153476
153MP0002080_prenatal_lethality0.71712664
154MP0002161_abnormal_fertility/fecundity0.70614637
155MP0000358_abnormal_cell_content/0.70551855
156MP0005646_abnormal_pituitary_gland0.69567019
157MP0005621_abnormal_cell_physiology0.68540298
158MP0002009_preneoplasia0.68199112
159MP0005384_cellular_phenotype0.68007443
160MP0001919_abnormal_reproductive_system0.67644472
161MP0004147_increased_porphyrin_level0.67604880
162MP0002796_impaired_skin_barrier0.66352070
163MP0009672_abnormal_birth_weight0.66210326
164MP0010155_abnormal_intestine_physiology0.66191566
165MP0001905_abnormal_dopamine_level0.65225017
166MP0001845_abnormal_inflammatory_respons0.64501553
167MP0001672_abnormal_embryogenesis/_devel0.62964702
168MP0005380_embryogenesis_phenotype0.62964702
169MP0006082_CNS_inflammation0.62116187

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.00318120
2Abnormality of glycolysis (HP:0004366)4.10900808
3Increased serum pyruvate (HP:0003542)3.98418948
4Aplastic anemia (HP:0001915)3.84537700
5Degeneration of anterior horn cells (HP:0002398)3.72361281
6Abnormality of the anterior horn cell (HP:0006802)3.72361281
7Abnormality of alanine metabolism (HP:0010916)3.35358298
8Hyperalaninemia (HP:0003348)3.35358298
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35358298
10Chromsome breakage (HP:0040012)3.11390305
11Cholecystitis (HP:0001082)3.04569688
12Abnormal gallbladder physiology (HP:0012438)3.04569688
13Testicular atrophy (HP:0000029)3.02839157
14Hypothermia (HP:0002045)3.00953962
15Abnormal umbilical cord blood vessels (HP:0011403)3.00532661
16Single umbilical artery (HP:0001195)3.00532661
17Abnormality of the fetal cardiovascular system (HP:0010948)3.00532661
18Hypoplasia of the capital femoral epiphysis (HP:0003090)2.92022509
19Abnormality of the umbilical cord (HP:0010881)2.90542260
20Thrombocytosis (HP:0001894)2.90356027
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87005510
22Type I transferrin isoform profile (HP:0003642)2.86569123
23Abnormal hair whorl (HP:0010721)2.84564981
24Progressive muscle weakness (HP:0003323)2.79946427
25Type 2 muscle fiber atrophy (HP:0003554)2.79659778
26IgM deficiency (HP:0002850)2.78419858
27Rough bone trabeculation (HP:0100670)2.75007717
28Abnormal mitochondria in muscle tissue (HP:0008316)2.73006918
29Myelodysplasia (HP:0002863)2.67516515
30Hypokinesia (HP:0002375)2.65836339
31Glucose intolerance (HP:0000833)2.64988368
32Pulmonary fibrosis (HP:0002206)2.64890518
33Short nail (HP:0001799)2.64646982
34Entropion (HP:0000621)2.64314587
35Acute necrotizing encephalopathy (HP:0006965)2.63021063
36Acute encephalopathy (HP:0006846)2.59159094
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58944565
38Muscle fiber atrophy (HP:0100295)2.58599166
39Trismus (HP:0000211)2.58157354
40Myositis (HP:0100614)2.57751863
41Agnosia (HP:0010524)2.55958763
42Patellar aplasia (HP:0006443)2.55533254
43Reduced subcutaneous adipose tissue (HP:0003758)2.51179232
44Abnormality of chromosome stability (HP:0003220)2.48287473
45Vertebral compression fractures (HP:0002953)2.47641000
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46463185
47Atrophy/Degeneration involving motor neurons (HP:0007373)2.44700335
48Hepatic necrosis (HP:0002605)2.42692185
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41106887
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41106887
51Recurrent bronchitis (HP:0002837)2.40816555
52Reduced antithrombin III activity (HP:0001976)2.37149484
53Increased serum lactate (HP:0002151)2.36997398
54Abnormality of the preputium (HP:0100587)2.35282554
5511 pairs of ribs (HP:0000878)2.35270525
56Male infertility (HP:0003251)2.34333668
57Tongue fasciculations (HP:0001308)2.33991200
58Lymphoma (HP:0002665)2.33719311
59Absent epiphyses (HP:0010577)2.33423338
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.33423338
61Bone marrow hypocellularity (HP:0005528)2.31091157
62Aplasia/Hypoplasia of the patella (HP:0006498)2.29516204
63Oral leukoplakia (HP:0002745)2.27745102
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.27415014
65Acute lymphatic leukemia (HP:0006721)2.27366038
66Meckel diverticulum (HP:0002245)2.25634844
67Increased CSF lactate (HP:0002490)2.25298097
68Abnormality of methionine metabolism (HP:0010901)2.24736539
69Mitochondrial inheritance (HP:0001427)2.24213410
70Abnormalities of placenta or umbilical cord (HP:0001194)2.22245217
71Abnormality of the distal phalanges of the toes (HP:0010182)2.21635634
72Premature rupture of membranes (HP:0001788)2.21149298
73Breast hypoplasia (HP:0003187)2.20683490
74Exercise intolerance (HP:0003546)2.20618244
75Abnormality of the ileum (HP:0001549)2.20059335
76Premature graying of hair (HP:0002216)2.19906771
77Supernumerary spleens (HP:0009799)2.19664204
78Abnormality of T cells (HP:0002843)2.18854737
79Lactic acidosis (HP:0003128)2.18639463
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.18503618
81Elevated erythrocyte sedimentation rate (HP:0003565)2.18107663
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17727501
83Abnormal protein N-linked glycosylation (HP:0012347)2.17727501
84Abnormal protein glycosylation (HP:0012346)2.17727501
85Abnormal glycosylation (HP:0012345)2.17727501
86Optic neuritis (HP:0100653)2.17177404
87Retrobulbar optic neuritis (HP:0100654)2.17177404
88Carpal bone hypoplasia (HP:0001498)2.14934435
89Medulloblastoma (HP:0002885)2.13950016
90Hand muscle atrophy (HP:0009130)2.13915214
91Abnormal number of erythroid precursors (HP:0012131)2.13301877
92Abnormal spermatogenesis (HP:0008669)2.13193530
93Gout (HP:0001997)2.11844682
94Amaurosis fugax (HP:0100576)2.11679557
95IgG deficiency (HP:0004315)2.09719607
96Sparse eyelashes (HP:0000653)2.07794717
97Hypergonadotropic hypogonadism (HP:0000815)2.06801745
98Agammaglobulinemia (HP:0004432)2.06421421
99Patchy hypopigmentation of hair (HP:0011365)2.05756680
100Pancreatic fibrosis (HP:0100732)2.05309933
101Premature ovarian failure (HP:0008209)2.04330246
102T lymphocytopenia (HP:0005403)2.04125227
103Abnormal trabecular bone morphology (HP:0100671)2.03962998
104Insulin resistance (HP:0000855)2.03903754
105White forelock (HP:0002211)2.02975706
106Absent thumb (HP:0009777)2.02614031
107Abnormality of T cell number (HP:0011839)2.01669020
108Abnormality of cells of the erythroid lineage (HP:0012130)2.00827902
109Secondary amenorrhea (HP:0000869)2.00497156
110Opisthotonus (HP:0002179)2.00015879
111Clubbing of toes (HP:0100760)1.98893542
112Progressive macrocephaly (HP:0004481)1.98870369
113Spastic paraparesis (HP:0002313)1.98850694
114Optic nerve coloboma (HP:0000588)1.97406764
115Acute myeloid leukemia (HP:0004808)1.97015962
116Microretrognathia (HP:0000308)1.95659814
117Upper limb muscle weakness (HP:0003484)1.94912432
118Fatigue (HP:0012378)1.94428503
119Panhypogammaglobulinemia (HP:0003139)1.92833459
120Abnormality of the labia minora (HP:0012880)1.92215918
121Abnormality of T cell physiology (HP:0011840)1.91613690
122Abnormality of the fingertips (HP:0001211)1.91510034
123Megaloblastic anemia (HP:0001889)1.90641481
124Cerebral edema (HP:0002181)1.90551866
125Muscle fibrillation (HP:0010546)1.90474130
126Cerebral hypomyelination (HP:0006808)1.89622633
127B lymphocytopenia (HP:0010976)1.89423971
128Abnormality of B cell number (HP:0010975)1.89423971
129Distal upper limb amyotrophy (HP:0007149)1.88851323
130Upper limb amyotrophy (HP:0009129)1.88851323
131Poikiloderma (HP:0001029)1.88654583
132Recurrent viral infections (HP:0004429)1.87529962
133True hermaphroditism (HP:0010459)1.87477693
134Vascular calcification (HP:0004934)1.86321179
135Asplenia (HP:0001746)1.86027982
136Orchitis (HP:0100796)1.85660903
137Duodenal stenosis (HP:0100867)1.84950855
138Small intestinal stenosis (HP:0012848)1.84950855
139Abnormal lung lobation (HP:0002101)1.84328445
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.83860538
141Ragged-red muscle fibers (HP:0003200)1.83671436
142Microglossia (HP:0000171)1.83634845
143Facial cleft (HP:0002006)1.83321540
144Thyroid carcinoma (HP:0002890)1.81247749
145Reticulocytopenia (HP:0001896)1.81047798
146Abnormality of the columella (HP:0009929)1.80017125
147Methylmalonic aciduria (HP:0012120)1.79397299
148Pancytopenia (HP:0001876)1.78914934
149Generalized aminoaciduria (HP:0002909)1.77612643
150Sloping forehead (HP:0000340)1.77478268
151Lymphopenia (HP:0001888)1.77283835
152Unilateral renal agenesis (HP:0000122)1.77139518
153Constricted visual fields (HP:0001133)1.77129800
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.74221630
155Horseshoe kidney (HP:0000085)1.74215066
156Abnormality of dentin (HP:0010299)1.74130368
157Hypoalphalipoproteinemia (HP:0003233)1.74101800
158Basal cell carcinoma (HP:0002671)1.73281304
159Abnormality of carpal bone ossification (HP:0006257)1.73239549
160Bronchitis (HP:0012387)1.73219845
161Severe combined immunodeficiency (HP:0004430)1.73158367
162Hepatocellular necrosis (HP:0001404)1.72898238
163Abnormality of the prostate (HP:0008775)1.72765414
164Cutaneous melanoma (HP:0012056)1.72676979
165Papillary thyroid carcinoma (HP:0002895)1.72541648
166Microvesicular hepatic steatosis (HP:0001414)1.72458867
167Abnormality of subcutaneous fat tissue (HP:0001001)1.72091060
168Unsteady gait (HP:0002317)1.71360244
169Nephroblastoma (Wilms tumor) (HP:0002667)1.70462049
170Nephrogenic diabetes insipidus (HP:0009806)1.69791562
171Progressive hearing impairment (HP:0001730)1.69302690
172Squamous cell carcinoma (HP:0002860)1.68198989
173Pancreatic cysts (HP:0001737)1.67344649
174Thyroiditis (HP:0100646)1.66948665
175Ketoacidosis (HP:0001993)1.66866641
176Aplasia/Hypoplasia of the spleen (HP:0010451)1.66443439
177Petechiae (HP:0000967)1.66203831
178Severe visual impairment (HP:0001141)1.65598846
179Spinal canal stenosis (HP:0003416)1.65253770
180Symptomatic seizures (HP:0011145)1.64812907
181Ectopic kidney (HP:0000086)1.64719546
182Prominent metopic ridge (HP:0005487)1.64092447
183Respiratory failure (HP:0002878)1.63976937
184Abnormality of serum amino acid levels (HP:0003112)1.62587649
185Progressive external ophthalmoplegia (HP:0000590)1.60786978
186Prolonged neonatal jaundice (HP:0006579)1.60523782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.68253450
2EPHA23.63929274
3CDC73.15962110
4WEE13.05874111
5LMTK23.02624313
6BUB12.89120609
7BRSK22.79903578
8SIK32.74661286
9PBK2.48691797
10MST1R2.39545411
11ACVR1B2.27078074
12MAP4K12.26475968
13LIMK12.25131588
14MAP3K122.20798343
15TSSK62.14115508
16TTK2.03226198
17PAK42.02593051
18CDK81.96960539
19EIF2AK11.93128567
20PDK21.92059980
21STK161.91665543
22MST41.88821973
23TXK1.86469338
24BRSK11.85336595
25SRPK11.85170637
26ARAF1.82793245
27VRK11.82516341
28EIF2AK31.78675277
29BMPR21.73362042
30PLK41.72908082
31MET1.71893340
32FLT31.68227664
33JAK31.54770571
34BCKDK1.52739041
35ERBB41.52123376
36PIM21.47469699
37MAP3K141.43186153
38DAPK11.42095650
39MAP3K31.40942577
40SMG11.39674160
41PRPF4B1.39251295
42MAP2K71.37714838
43BRAF1.36228903
44CCNB11.34678620
45ZAP701.32539455
46PTK21.31699871
47TEC1.27521850
48MAPKAPK31.25192849
49MUSK1.21757625
50PLK11.21324758
51STK241.20122257
52PLK31.18309413
53ATR1.17041067
54KIT1.16371665
55MKNK11.15531312
56CDK191.11668187
57RAF11.08305156
58CDK71.07747400
59BTK1.06524337
60NEK11.06416486
61ZAK1.05824294
62TAOK21.04933462
63IKBKE1.04221500
64TGFBR11.01970665
65STK38L1.01422899
66PASK0.97321572
67PIM10.95968489
68IRAK40.95373173
69SYK0.94835857
70IRAK30.94210824
71MKNK20.93062899
72TNK20.93057529
73PRKCI0.91355888
74CDK90.90389406
75KDR0.89523812
76TESK20.86702860
77CAMKK20.86103973
78RPS6KB20.84254930
79NME10.83328719
80MAP3K80.82646132
81ABL20.80569184
82NME20.79628360
83MAP3K130.76506895
84PLK20.74773019
85CASK0.74685153
86ERN10.74133367
87ERBB30.73591276
88NEK60.72336655
89IKBKB0.72020216
90AURKA0.71696221
91CSNK1G30.71368817
92PAK10.70725254
93CDK120.68380782
94MINK10.67192352
95MOS0.66296200
96MAP2K30.65286006
97CLK10.63226106
98MAP2K60.62994355
99ADRBK20.62404560
100SCYL20.61483720
101NEK20.61155442
102TRIM280.60086066
103YES10.60025669
104AKT20.59912892
105ILK0.58932372
106CHEK10.58865140
107RIPK40.58440170
108RPS6KB10.57764245
109CHEK20.57654678
110CSNK1A1L0.54881373
111STK40.54280855
112MAP3K110.53851986
113CHUK0.53427596
114SGK20.53171436
115TESK10.52056294
116EEF2K0.51573140
117ATM0.51087682
118STK100.50140977
119IRAK20.50042669
120AURKB0.49946745
121RPS6KA40.49263567
122CDK40.49172911
123MARK30.48914703
124LCK0.48375551
125AKT30.47253290
126CSNK1G10.46972515
127PHKG10.46285083
128PHKG20.46285083
129LATS20.45856216
130TYK20.44884230
131MATK0.44142651
132CDK30.44135908
133CSNK2A20.42775627
134TAF10.41870723
135CSNK2A10.40829074
136CDK20.39903523
137CSF1R0.39752265
138LRRK20.39663655
139EIF2AK20.39282261
140BMX0.38695344
141MAPK130.38466762
142ITK0.38237672
143EPHB20.37666902
144CAMK2G0.35828448
145STK30.31598692
146PRKG20.31379762
147PTK2B0.31256657
148CDK140.30026836
149CDK11A0.28721488
150CDK180.28000077
151CAMK2D0.27911702
152CSNK1G20.27727312

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.95071764
2Mismatch repair_Homo sapiens_hsa034303.52207037
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96587946
4RNA polymerase_Homo sapiens_hsa030202.72857881
5Homologous recombination_Homo sapiens_hsa034402.71445280
6Proteasome_Homo sapiens_hsa030502.70443152
7Base excision repair_Homo sapiens_hsa034102.52420155
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.51099273
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37034500
10Nucleotide excision repair_Homo sapiens_hsa034202.30104182
11Basal transcription factors_Homo sapiens_hsa030222.27513541
12Sulfur relay system_Homo sapiens_hsa041222.26839921
13Spliceosome_Homo sapiens_hsa030402.18570362
14Cell cycle_Homo sapiens_hsa041102.16070008
15Biosynthesis of amino acids_Homo sapiens_hsa012302.15832684
16RNA transport_Homo sapiens_hsa030132.01525099
17Non-homologous end-joining_Homo sapiens_hsa034501.93874064
18Fatty acid elongation_Homo sapiens_hsa000621.89066986
19Pyrimidine metabolism_Homo sapiens_hsa002401.87498424
20Ribosome_Homo sapiens_hsa030101.86918081
21Folate biosynthesis_Homo sapiens_hsa007901.86723116
22Fanconi anemia pathway_Homo sapiens_hsa034601.85423471
23RNA degradation_Homo sapiens_hsa030181.81720165
24Vitamin B6 metabolism_Homo sapiens_hsa007501.76678512
25Primary immunodeficiency_Homo sapiens_hsa053401.76490969
26Carbon metabolism_Homo sapiens_hsa012001.67397703
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.66131967
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61812405
29Glutathione metabolism_Homo sapiens_hsa004801.61685907
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59785209
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58000177
32Pentose phosphate pathway_Homo sapiens_hsa000301.54323439
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53073922
34Galactose metabolism_Homo sapiens_hsa000521.44688693
35Pyruvate metabolism_Homo sapiens_hsa006201.37946581
36Epstein-Barr virus infection_Homo sapiens_hsa051691.32534014
37mRNA surveillance pathway_Homo sapiens_hsa030151.30991567
38Purine metabolism_Homo sapiens_hsa002301.28221548
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26082868
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25072649
41Thyroid cancer_Homo sapiens_hsa052161.23838476
42Antigen processing and presentation_Homo sapiens_hsa046121.22554782
43Herpes simplex infection_Homo sapiens_hsa051681.21131856
44Sulfur metabolism_Homo sapiens_hsa009201.17378927
45p53 signaling pathway_Homo sapiens_hsa041151.16053221
46Protein export_Homo sapiens_hsa030601.15969653
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09557122
48Oocyte meiosis_Homo sapiens_hsa041141.05780912
49Fructose and mannose metabolism_Homo sapiens_hsa000511.04013717
50Measles_Homo sapiens_hsa051621.02988360
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00003308
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99935155
53Arginine biosynthesis_Homo sapiens_hsa002200.99665823
54Steroid biosynthesis_Homo sapiens_hsa001000.96471861
55Shigellosis_Homo sapiens_hsa051310.96038788
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93461643
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91547706
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91112877
59Propanoate metabolism_Homo sapiens_hsa006400.90807739
60Selenocompound metabolism_Homo sapiens_hsa004500.90318269
61Type I diabetes mellitus_Homo sapiens_hsa049400.89613019
62Legionellosis_Homo sapiens_hsa051340.89453651
63Allograft rejection_Homo sapiens_hsa053300.89041180
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88258639
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88227070
66Alzheimers disease_Homo sapiens_hsa050100.86803873
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.85800737
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.84931676
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.84058206
70One carbon pool by folate_Homo sapiens_hsa006700.83410921
71Influenza A_Homo sapiens_hsa051640.83162355
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83151900
73Hematopoietic cell lineage_Homo sapiens_hsa046400.81677252
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81462112
75Leishmaniasis_Homo sapiens_hsa051400.80150205
76Arginine and proline metabolism_Homo sapiens_hsa003300.79343742
77Metabolic pathways_Homo sapiens_hsa011000.78860355
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.77161362
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76814153
80B cell receptor signaling pathway_Homo sapiens_hsa046620.76096101
81Synaptic vesicle cycle_Homo sapiens_hsa047210.76087969
82Huntingtons disease_Homo sapiens_hsa050160.75108935
83T cell receptor signaling pathway_Homo sapiens_hsa046600.74440465
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72155980
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71182159
86Phenylalanine metabolism_Homo sapiens_hsa003600.70487566
87HTLV-I infection_Homo sapiens_hsa051660.70397171
88Hepatitis B_Homo sapiens_hsa051610.69689841
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66034392
90Viral carcinogenesis_Homo sapiens_hsa052030.65974061
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62906881
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62773365
93Peroxisome_Homo sapiens_hsa041460.60844522
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60555425
95Acute myeloid leukemia_Homo sapiens_hsa052210.59474795
96Apoptosis_Homo sapiens_hsa042100.57874675
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57445362
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56660816
99Tyrosine metabolism_Homo sapiens_hsa003500.56590380
100N-Glycan biosynthesis_Homo sapiens_hsa005100.56550913
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.56265749
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56234814
103Graft-versus-host disease_Homo sapiens_hsa053320.55861687
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.54642227
105Salmonella infection_Homo sapiens_hsa051320.54583048
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54454976
107Fatty acid metabolism_Homo sapiens_hsa012120.54104056
108Asthma_Homo sapiens_hsa053100.51956065
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49370708
110Parkinsons disease_Homo sapiens_hsa050120.48937324
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.48535759
112Olfactory transduction_Homo sapiens_hsa047400.48392056
113Colorectal cancer_Homo sapiens_hsa052100.47618099
114Other glycan degradation_Homo sapiens_hsa005110.46772385
115beta-Alanine metabolism_Homo sapiens_hsa004100.46688647
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46571633
117Collecting duct acid secretion_Homo sapiens_hsa049660.46221720
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45808135
119Prolactin signaling pathway_Homo sapiens_hsa049170.44925351
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.44846632
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.44240416
122Vibrio cholerae infection_Homo sapiens_hsa051100.43282649
123Rheumatoid arthritis_Homo sapiens_hsa053230.43203324
124Tuberculosis_Homo sapiens_hsa051520.42941550
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42599001
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42345903
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41702740
128Chemokine signaling pathway_Homo sapiens_hsa040620.41010701
129Autoimmune thyroid disease_Homo sapiens_hsa053200.40623321
130Long-term potentiation_Homo sapiens_hsa047200.39251918
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38098178
132Sphingolipid metabolism_Homo sapiens_hsa006000.37151613
133HIF-1 signaling pathway_Homo sapiens_hsa040660.36562571
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34373989
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33211337
136Osteoclast differentiation_Homo sapiens_hsa043800.32403498
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32370058
138Regulation of autophagy_Homo sapiens_hsa041400.32000406
139Toxoplasmosis_Homo sapiens_hsa051450.31008190
140Non-small cell lung cancer_Homo sapiens_hsa052230.30697358
141Pertussis_Homo sapiens_hsa051330.30005256
142Hippo signaling pathway_Homo sapiens_hsa043900.29731998
143Oxidative phosphorylation_Homo sapiens_hsa001900.28925443
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28884294
145Pancreatic cancer_Homo sapiens_hsa052120.28608524
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27638052
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27178752
148Butanoate metabolism_Homo sapiens_hsa006500.26990303
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26850893
150Bladder cancer_Homo sapiens_hsa052190.26533125
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26286347
152TNF signaling pathway_Homo sapiens_hsa046680.24254130
153Phagosome_Homo sapiens_hsa041450.24016912
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23362963
155Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14860241
156Adherens junction_Homo sapiens_hsa045200.14695825

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