TOMM40L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.34618276
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.00076720
3NADH metabolic process (GO:0006734)4.85833109
4ATP synthesis coupled proton transport (GO:0015986)4.53768153
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53768153
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46944635
7oxaloacetate metabolic process (GO:0006107)4.38478716
8respiratory electron transport chain (GO:0022904)4.37210138
9electron transport chain (GO:0022900)4.27613809
10succinate metabolic process (GO:0006105)4.23706792
11negative regulation of erythrocyte differentiation (GO:0045647)4.20538888
12aspartate family amino acid catabolic process (GO:0009068)3.94464105
13lysine catabolic process (GO:0006554)3.88140369
14lysine metabolic process (GO:0006553)3.88140369
15pinocytosis (GO:0006907)3.85826951
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.78323998
17oxidative phosphorylation (GO:0006119)3.72605390
18Golgi transport vesicle coating (GO:0048200)3.71048037
19COPI coating of Golgi vesicle (GO:0048205)3.71048037
20protein localization to endosome (GO:0036010)3.68806951
212-oxoglutarate metabolic process (GO:0006103)3.63581230
22cellular ketone body metabolic process (GO:0046950)3.62950332
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.53648504
24regulation of acyl-CoA biosynthetic process (GO:0050812)3.51969963
25synaptic vesicle exocytosis (GO:0016079)3.47997831
26creatine metabolic process (GO:0006600)3.47443099
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.43231651
28L-phenylalanine metabolic process (GO:0006558)3.43231651
29regulation of cofactor metabolic process (GO:0051193)3.38041257
30regulation of coenzyme metabolic process (GO:0051196)3.38041257
31regulation of synapse structural plasticity (GO:0051823)3.35258304
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.33735894
33regulation of early endosome to late endosome transport (GO:2000641)3.32073221
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31413242
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31016374
36L-phenylalanine catabolic process (GO:0006559)3.31016374
37proline biosynthetic process (GO:0006561)3.30691372
38glycosphingolipid catabolic process (GO:0046479)3.28578388
39negative regulation of fibrinolysis (GO:0051918)3.28289843
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.25262850
41dicarboxylic acid catabolic process (GO:0043649)3.22598075
42response to thyroid hormone (GO:0097066)3.19011365
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17880582
44ATP biosynthetic process (GO:0006754)3.17102425
45short-chain fatty acid metabolic process (GO:0046459)3.15855111
46urea cycle (GO:0000050)3.14802407
47response to peptidoglycan (GO:0032494)3.14510748
48ketone body metabolic process (GO:1902224)3.12378537
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12362893
50gluconeogenesis (GO:0006094)3.11570942
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11288387
52protein retention in ER lumen (GO:0006621)3.10702766
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.10520588
54neuronal action potential propagation (GO:0019227)3.10320964
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.08600649
56regulation of oxidative phosphorylation (GO:0002082)3.08546420
57urea metabolic process (GO:0019627)3.06759833
58glyoxylate metabolic process (GO:0046487)3.04868372
59pentose-phosphate shunt (GO:0006098)3.02060261
60muscle filament sliding (GO:0030049)2.99714390
61actin-myosin filament sliding (GO:0033275)2.99714390
62fructose metabolic process (GO:0006000)2.99179822
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98432039
64cardiac muscle contraction (GO:0060048)2.98216360
65synaptic vesicle maturation (GO:0016188)2.97010303
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96773501
67tricarboxylic acid metabolic process (GO:0072350)2.95827592
68glutamate secretion (GO:0014047)2.95534013
69glutamate metabolic process (GO:0006536)2.95377102
70cell-substrate adherens junction assembly (GO:0007045)2.95135013
71focal adhesion assembly (GO:0048041)2.95135013
72sarcomere organization (GO:0045214)2.94980677
73nitrogen cycle metabolic process (GO:0071941)2.93059241
74cellular hyperosmotic response (GO:0071474)2.92440825
75branched-chain amino acid catabolic process (GO:0009083)2.91218722
76behavioral response to cocaine (GO:0048148)2.90799336
77regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90528133
78coenzyme catabolic process (GO:0009109)2.88156650
79dicarboxylic acid biosynthetic process (GO:0043650)2.86903189
80barbed-end actin filament capping (GO:0051016)2.85327529
81proline metabolic process (GO:0006560)2.84426448
82regulation of superoxide anion generation (GO:0032928)2.84083789
83regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84055199
84hexose biosynthetic process (GO:0019319)2.83383579
85fatty acid beta-oxidation (GO:0006635)2.83188072
86neurotransmitter-gated ion channel clustering (GO:0072578)2.82899002
87glycolipid catabolic process (GO:0019377)2.82835078
88nuclear pore complex assembly (GO:0051292)2.81771933
89regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80922583
90negative regulation of cell size (GO:0045792)2.80551117
91cell communication by electrical coupling (GO:0010644)2.80541097
92acetyl-CoA metabolic process (GO:0006084)2.80362216
93positive regulation of lipoprotein lipase activity (GO:0051006)2.78444112
94positive regulation of triglyceride lipase activity (GO:0061365)2.78444112
95fatty acid catabolic process (GO:0009062)2.74383519
96synaptic vesicle docking involved in exocytosis (GO:0016081)2.72145084
97regulation of cell communication by electrical coupling (GO:0010649)2.71000953
98glycolytic process (GO:0006096)2.70930084
99regulation of cellular respiration (GO:0043457)2.70911998
100gamma-aminobutyric acid transport (GO:0015812)2.70012636
101ATP hydrolysis coupled proton transport (GO:0015991)2.69843981
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.69843981
1033-UTR-mediated mRNA stabilization (GO:0070935)2.69154854
104neurotransmitter secretion (GO:0007269)2.66990053
105cellular response to thyroid hormone stimulus (GO:0097067)2.66857898
106cardiac myofibril assembly (GO:0055003)2.66235202
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66076007
108bile acid biosynthetic process (GO:0006699)2.64839531
109skeletal muscle contraction (GO:0003009)2.63332915
110monocarboxylic acid catabolic process (GO:0072329)2.63133584
111glucose 6-phosphate metabolic process (GO:0051156)2.62287406
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61733318
113monosaccharide biosynthetic process (GO:0046364)2.61248784
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60935355
115purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60674530
116stress fiber assembly (GO:0043149)2.60204110
117NADPH regeneration (GO:0006740)2.59700795
118adherens junction assembly (GO:0034333)2.59670814
119regulation of actin filament-based movement (GO:1903115)2.59123100
120inner mitochondrial membrane organization (GO:0007007)2.58042421
121regulation of sulfur metabolic process (GO:0042762)2.57869890
122vocalization behavior (GO:0071625)2.57564211
123endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57449727
124regulation of triglyceride catabolic process (GO:0010896)2.57368674
125regulation of relaxation of muscle (GO:1901077)2.57189391
126hydrogen ion transmembrane transport (GO:1902600)2.57055780
127negative regulation of necroptotic process (GO:0060546)2.56505583
128purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56254128
129protein localization to synapse (GO:0035418)2.56069044
130cell communication involved in cardiac conduction (GO:0086065)2.55314728
131regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55260166
132mitochondrial fusion (GO:0008053)2.55212321
133fatty acid oxidation (GO:0019395)2.54685907
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54563987
135positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54329599
136carnitine shuttle (GO:0006853)2.53364256
137mannose metabolic process (GO:0006013)2.53032403
138regulation of fibrinolysis (GO:0051917)2.51669651
139branched-chain amino acid metabolic process (GO:0009081)2.51331685
140positive regulation of protein dephosphorylation (GO:0035307)2.50658635
141aerobic respiration (GO:0009060)2.50210909
142regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49988233
143ethanol oxidation (GO:0006069)2.49500635
144alpha-linolenic acid metabolic process (GO:0036109)2.49364383
145glucose catabolic process (GO:0006007)2.49278163
146peptidyl-arginine omega-N-methylation (GO:0035247)2.49260639
147lipid oxidation (GO:0034440)2.48737247
148cholesterol catabolic process (GO:0006707)2.48378422
149sterol catabolic process (GO:0016127)2.48378422
150regulation of synaptic vesicle exocytosis (GO:2000300)2.48369863
151aromatic amino acid family catabolic process (GO:0009074)2.48070070
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.47682393
153NADH dehydrogenase complex assembly (GO:0010257)2.47682393
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47682393
155regulation of cholesterol biosynthetic process (GO:0045540)2.44713505
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41581183
157cellular protein complex localization (GO:0034629)2.40945394
158regulation of cholesterol esterification (GO:0010872)2.40014320
159DNA unwinding involved in DNA replication (GO:0006268)2.39525211
160mitotic chromosome condensation (GO:0007076)2.39408678
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.38193889
162glycogen catabolic process (GO:0005980)2.35138863
163glutamine family amino acid biosynthetic process (GO:0009084)2.32220597
164amyloid precursor protein catabolic process (GO:0042987)2.31906733
165sodium ion export (GO:0071436)2.31369691
166regulation of cholesterol homeostasis (GO:2000188)2.30949277
167pore complex assembly (GO:0046931)2.29690443
168cellular response to arsenic-containing substance (GO:0071243)2.29333093
169regulation of NFAT protein import into nucleus (GO:0051532)2.28832532
170regulation of macrophage chemotaxis (GO:0010758)2.28831704
171oligosaccharide catabolic process (GO:0009313)2.28812498
172regulation of glucose import in response to insulin stimulus (GO:2001273)2.28615919
173protein-lipid complex assembly (GO:0065005)2.28064972
174nucleobase-containing small molecule interconversion (GO:0015949)2.27945797
175response to muramyl dipeptide (GO:0032495)2.27789167
176positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.27639208
177regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.27639208
178nucleoside diphosphate biosynthetic process (GO:0009133)2.25921927
179ceramide catabolic process (GO:0046514)2.25644478
180positive regulation of myotube differentiation (GO:0010831)2.25379686
181glucan catabolic process (GO:0009251)2.25040652
182cell-substrate junction assembly (GO:0007044)2.24991739
183cytoskeletal anchoring at plasma membrane (GO:0007016)2.23567615
184nuclear pore organization (GO:0006999)2.23487600
185peptidyl-glutamic acid carboxylation (GO:0017187)2.23460204
186protein carboxylation (GO:0018214)2.23460204
187amyloid precursor protein metabolic process (GO:0042982)2.21526393
188activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.21064057
189striated muscle contraction (GO:0006941)2.20264430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.76164642
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.55303026
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.53336137
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.50993914
5EZH2_22144423_ChIP-Seq_EOC_Human3.31686891
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.17577320
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00091869
8E2F7_22180533_ChIP-Seq_HELA_Human2.89820506
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80167304
10MYC_22102868_ChIP-Seq_BL_Human2.69248181
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68697486
12VDR_21846776_ChIP-Seq_THP-1_Human2.65138823
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56927188
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.45389777
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.44625441
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.36075291
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28564023
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.25096110
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.14677504
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11672644
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.06799947
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04564632
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03886898
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98716457
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97225696
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94379237
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.93651439
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.93102502
29SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.90070228
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82964754
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82660006
32RACK7_27058665_Chip-Seq_MCF-7_Human1.82360620
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82306937
34REST_21632747_ChIP-Seq_MESCs_Mouse1.77675000
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.77307301
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76795301
37TCF7_22412390_ChIP-Seq_EML_Mouse1.74183813
38CLOCK_20551151_ChIP-Seq_293T_Human1.72920652
39KDM2B_26808549_Chip-Seq_DND41_Human1.71957359
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71043145
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69513749
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64753884
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62434036
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62106943
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60281295
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59336290
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57957631
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55191931
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54410663
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53432578
51LXR_22292898_ChIP-Seq_THP-1_Human1.52613834
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51750577
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48972520
54VDR_24763502_ChIP-Seq_THP-1_Human1.48188580
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46454649
56MAF_26560356_Chip-Seq_TH1_Human1.45850323
57* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45764678
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44247907
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43194677
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40186513
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39177203
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35436439
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35091083
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35005942
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35005942
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.34391370
67* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33958452
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33654846
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33441598
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32826403
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32490451
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.32114381
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30837050
74DROSHA_22980978_ChIP-Seq_HELA_Human1.30680364
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30326299
76KDM2B_26808549_Chip-Seq_K562_Human1.28732002
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28389122
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28189432
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26725615
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26384347
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25508778
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25442553
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24836486
84* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24547129
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23932552
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23864666
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.23756097
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23037303
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22820884
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.22786359
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22601789
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22156902
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22010402
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21910313
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21055958
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19828051
97* CTCF_27219007_Chip-Seq_Bcells_Human1.18995305
98MAF_26560356_Chip-Seq_TH2_Human1.18765107
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17728305
100GATA1_22025678_ChIP-Seq_K562_Human1.17687839
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17577633
102TAF15_26573619_Chip-Seq_HEK293_Human1.17368141
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.16676539
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.16430170
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15220842
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14509096
107SMC4_20622854_ChIP-Seq_HELA_Human1.14094259
108NCOR1_26117541_ChIP-Seq_K562_Human1.13500325
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.12846974
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11781573
111* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11608290
112TFEB_21752829_ChIP-Seq_HELA_Human1.10961063
113* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10884111
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.10372244
115* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09728583
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08392894
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08307556
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.07967089
119BCL6_27268052_Chip-Seq_Bcells_Human1.07524406
120ATF3_27146783_Chip-Seq_COLON_Human1.07412155
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06576732
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06383669
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.06144129
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06054158
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05795415
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05380631
127CREB1_26743006_Chip-Seq_LNCaP_Human1.05279513
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04821896
129UTX_26944678_Chip-Seq_JUKART_Human1.04134025
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03582630
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03281674
132MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03022172
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01853434
134* SPI1_23127762_ChIP-Seq_K562_Human1.01384921
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.01370088
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99106759
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98964615
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98873286
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.98723647
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.98642642
141* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98571316
142HTT_18923047_ChIP-ChIP_STHdh_Human0.98464687
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98429338
144ETS1_21867929_ChIP-Seq_TH2_Mouse0.97864113
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.97171760
146KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96932157
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93705536
148P68_20966046_ChIP-Seq_HELA_Human0.93232773
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.92835249
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92659459
151GBX2_23144817_ChIP-Seq_PC3_Human0.91693735
152ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91248263
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87990017
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87109520
155BCOR_27268052_Chip-Seq_Bcells_Human0.86917904
156TAF2_19829295_ChIP-Seq_ESCs_Human0.86294847
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85400108
158ZNF263_19887448_ChIP-Seq_K562_Human0.84298354
159EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84287063
160EZH2_27304074_Chip-Seq_ESCs_Mouse0.81197484
161* SA1_27219007_Chip-Seq_Bcells_Human0.80895835
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80842244
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80746091
164ETS1_20019798_ChIP-Seq_JURKAT_Human0.79602175
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79467925
166* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78353079
167HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78025232
168SOX2_21211035_ChIP-Seq_LN229_Human0.76881716
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76076472
170MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75676713
171EGR1_19032775_ChIP-ChIP_M12_Human0.75130479
172RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74721808
173* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74719317
174TBX20_22328084_ChIP-Seq_HEART_Mouse0.74372923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.81010143
2MP0002837_dystrophic_cardiac_calcinosis4.40115464
3MP0004859_abnormal_synaptic_plasticity3.30853893
4MP0005058_abnormal_lysosome_morphology3.09059588
5MP0000751_myopathy2.92499669
6MP0005360_urolithiasis2.90641413
7MP0002822_catalepsy2.89353700
8MP0003705_abnormal_hypodermis_morpholog2.86355549
9MP0002139_abnormal_hepatobiliary_system2.84136434
10MP0005085_abnormal_gallbladder_physiolo2.69702770
11MP0004084_abnormal_cardiac_muscle2.67644091
12MP0004215_abnormal_myocardial_fiber2.58255540
13MP0003191_abnormal_cellular_cholesterol2.57685182
14MP0005083_abnormal_biliary_tract2.57167174
15MP0003880_abnormal_central_pattern2.54205767
16MP0003646_muscle_fatigue2.50817684
17MP0004036_abnormal_muscle_relaxation2.46986723
18MP0005365_abnormal_bile_salt2.42338097
19MP0003806_abnormal_nucleotide_metabolis2.40621148
20MP0000749_muscle_degeneration2.39062702
21MP0008875_abnormal_xenobiotic_pharmacok2.38211878
22MP0006036_abnormal_mitochondrial_physio2.34327319
23MP0003303_peritoneal_inflammation2.33185283
24MP0004185_abnormal_adipocyte_glucose2.27023078
25MP0003635_abnormal_synaptic_transmissio2.21129392
26MP0009745_abnormal_behavioral_response2.02483582
27MP0002877_abnormal_melanocyte_morpholog2.02254817
28MP0005330_cardiomyopathy2.01424819
29MP0004130_abnormal_muscle_cell1.99981602
30MP0002064_seizures1.98146052
31MP0001968_abnormal_touch/_nociception1.97851938
32MP0003436_decreased_susceptibility_to1.97256816
33MP0004270_analgesia1.89802548
34MP0009046_muscle_twitch1.87267766
35MP0002736_abnormal_nociception_after1.86208904
36MP0008260_abnormal_autophagy1.82351698
37MP0005666_abnormal_adipose_tissue1.71083672
38MP0002063_abnormal_learning/memory/cond1.70870937
39MP0002272_abnormal_nervous_system1.70016387
40MP0005332_abnormal_amino_acid1.62173214
41MP0002972_abnormal_cardiac_muscle1.60569749
42MP0006035_abnormal_mitochondrial_morpho1.60139801
43MP0005464_abnormal_platelet_physiology1.58579686
44MP0005076_abnormal_cell_differentiation1.56399561
45MP0002909_abnormal_adrenal_gland1.56159265
46MP0010234_abnormal_vibrissa_follicle1.54318490
47MP0004085_abnormal_heartbeat1.51307200
48MP0010329_abnormal_lipoprotein_level1.51278296
49MP0002269_muscular_atrophy1.50735270
50MP0003566_abnormal_cell_adhesion1.49213189
51MP0003172_abnormal_lysosome_physiology1.47635773
52MP0003329_amyloid_beta_deposits1.46933156
53MP0003137_abnormal_impulse_conducting1.46753244
54MP0002572_abnormal_emotion/affect_behav1.46241884
55MP0004145_abnormal_muscle_electrophysio1.44342814
56MP0005535_abnormal_body_temperature1.42617158
57MP0005620_abnormal_muscle_contractility1.40665827
58MP0001666_abnormal_nutrient_absorption1.39982375
59MP0003195_calcinosis1.39554150
60MP0001529_abnormal_vocalization1.38756746
61MP0001661_extended_life_span1.38182272
62MP0001501_abnormal_sleep_pattern1.37901801
63MP0005584_abnormal_enzyme/coenzyme_acti1.37616152
64MP0000747_muscle_weakness1.36802855
65MP0004087_abnormal_muscle_fiber1.36527050
66MP0005409_darkened_coat_color1.35910410
67MP0008775_abnormal_heart_ventricle1.34138571
68MP0003300_gastrointestinal_ulcer1.33520415
69MP0003183_abnormal_peptide_metabolism1.32401449
70MP0002733_abnormal_thermal_nociception1.29590273
71MP0002734_abnormal_mechanical_nocicepti1.27634742
72MP0003221_abnormal_cardiomyocyte_apopto1.26582619
73MP0002735_abnormal_chemical_nociception1.26267705
74MP0004142_abnormal_muscle_tone1.25952312
75MP0000858_altered_metastatic_potential1.24818120
76MP0009333_abnormal_splenocyte_physiolog1.23992149
77MP0004043_abnormal_pH_regulation1.23601669
78MP0003453_abnormal_keratinocyte_physiol1.23180811
79MP0001544_abnormal_cardiovascular_syste1.23174144
80MP0005385_cardiovascular_system_phenoty1.23174144
81MP0001915_intracranial_hemorrhage1.21128050
82MP0005375_adipose_tissue_phenotype1.21005115
83MP0004147_increased_porphyrin_level1.20058746
84MP0003091_abnormal_cell_migration1.19631668
85MP0001849_ear_inflammation1.17709380
86MP0001970_abnormal_pain_threshold1.17572945
87MP0002118_abnormal_lipid_homeostasis1.17248738
88MP0000733_abnormal_muscle_development1.16414540
89MP0006276_abnormal_autonomic_nervous1.16378275
90MP0010352_gastrointestinal_tract_polyps1.16091808
91MP0001853_heart_inflammation1.15121912
92MP0002067_abnormal_sensory_capabilities1.15067244
93MP0000750_abnormal_muscle_regeneration1.14437812
94MP0004924_abnormal_behavior1.14219512
95MP0005386_behavior/neurological_phenoty1.14219512
96MP0006138_congestive_heart_failure1.12886247
97MP0001730_embryonic_growth_arrest1.11830138
98MP0002332_abnormal_exercise_endurance1.11513884
99MP0004484_altered_response_of1.11418159
100MP0002090_abnormal_vision1.11134329
101MP0001440_abnormal_grooming_behavior1.10682142
102MP0001486_abnormal_startle_reflex1.08409683
103MP0008874_decreased_physiological_sensi1.08263635
104MP0005670_abnormal_white_adipose1.08150920
105MP0001905_abnormal_dopamine_level1.07997284
106MP0004510_myositis1.07669886
107MP0005319_abnormal_enzyme/_coenzyme1.06352074
108MP0009780_abnormal_chondrocyte_physiolo1.05353840
109MP0000604_amyloidosis1.05296571
110MP0002106_abnormal_muscle_physiology1.04845835
111MP0000343_altered_response_to1.04780307
112MP0003879_abnormal_hair_cell1.04159542
113MP0004947_skin_inflammation1.04128022
114MP0009840_abnormal_foam_cell1.03652842
115MP0003690_abnormal_glial_cell1.02969359
116MP0004233_abnormal_muscle_weight1.00719770
117MP0002419_abnormal_innate_immunity0.99975507
118MP0004808_abnormal_hematopoietic_stem0.99810097
119MP0000759_abnormal_skeletal_muscle0.99565137
120MP0008872_abnormal_physiological_respon0.99492704
121MP0002971_abnormal_brown_adipose0.99402091
122MP0005166_decreased_susceptibility_to0.99048303
123MP0000230_abnormal_systemic_arterial0.95800535
124MP0003828_pulmonary_edema0.95245224
125MP0003633_abnormal_nervous_system0.94998534
126MP0000013_abnormal_adipose_tissue0.94305169
127MP0008569_lethality_at_weaning0.92818936
128MP0003252_abnormal_bile_duct0.92634118
129MP0000920_abnormal_myelination0.92397327
130MP0000678_abnormal_parathyroid_gland0.91250739
131MP0005266_abnormal_metabolism0.89363564
132MP0002396_abnormal_hematopoietic_system0.89334014
133MP0002078_abnormal_glucose_homeostasis0.89228082
134MP0000609_abnormal_liver_physiology0.88888627
135MP0005646_abnormal_pituitary_gland0.88805560
136MP0005165_increased_susceptibility_to0.88573040
137MP0004858_abnormal_nervous_system0.87662660
138MP0002066_abnormal_motor_capabilities/c0.87595605
139MP0009672_abnormal_birth_weight0.87463765
140MP0000003_abnormal_adipose_tissue0.86170286
141MP0005000_abnormal_immune_tolerance0.86014877
142MP0003111_abnormal_nucleus_morphology0.85576578
143MP0004811_abnormal_neuron_physiology0.85388154
144MP0005025_abnormal_response_to0.85251844
145MP0003656_abnormal_erythrocyte_physiolo0.84363903
146MP0009278_abnormal_bone_marrow0.84118303
147MP0005084_abnormal_gallbladder_morpholo0.84042276
148MP0001835_abnormal_antigen_presentation0.83636733
149MP0005621_abnormal_cell_physiology0.83585030
150MP0003075_altered_response_to0.83494965
151MP0003868_abnormal_feces_composition0.82319814
152MP0001764_abnormal_homeostasis0.82243111
153MP0005369_muscle_phenotype0.80468786
154MP0010630_abnormal_cardiac_muscle0.79981046
155MP0002089_abnormal_postnatal_growth/wei0.74220251
156MP0002148_abnormal_hypersensitivity_rea0.74137008
157MP0002998_abnormal_bone_remodeling0.72729865
158MP0001727_abnormal_embryo_implantation0.71691040
159MP0003448_altered_tumor_morphology0.71678378
160MP0003634_abnormal_glial_cell0.70858572
161MP0002796_impaired_skin_barrier0.70370904

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)4.33115201
2Abnormal mitochondria in muscle tissue (HP:0008316)4.32395154
3Nemaline bodies (HP:0003798)4.31783093
4Acute necrotizing encephalopathy (HP:0006965)4.25625536
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.23757591
6Hepatocellular necrosis (HP:0001404)4.10572305
7Hepatic necrosis (HP:0002605)4.08735128
8Acute encephalopathy (HP:0006846)4.03769049
9Centrally nucleated skeletal muscle fibers (HP:0003687)4.01211876
10Exercise-induced myalgia (HP:0003738)3.83570638
11Mitochondrial inheritance (HP:0001427)3.75653028
12Myokymia (HP:0002411)3.74809241
13Sudden death (HP:0001699)3.66593501
14Myoglobinuria (HP:0002913)3.59450035
15Pheochromocytoma (HP:0002666)3.56271664
16Progressive macrocephaly (HP:0004481)3.55317708
17Cerebral edema (HP:0002181)3.54591167
18Neuroendocrine neoplasm (HP:0100634)3.52532942
19Distal lower limb amyotrophy (HP:0008944)3.44497816
20Distal lower limb muscle weakness (HP:0009053)3.41469984
21Increased CSF lactate (HP:0002490)3.41335984
22Ketoacidosis (HP:0001993)3.37838782
23Exercise-induced muscle cramps (HP:0003710)3.31291752
24Ketosis (HP:0001946)3.30109807
25Increased connective tissue (HP:0009025)3.14190503
26Type 1 muscle fiber predominance (HP:0003803)3.10997136
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.10120855
28Lactic acidosis (HP:0003128)3.08047346
29Focal motor seizures (HP:0011153)3.05028246
30Myopathic facies (HP:0002058)3.04924549
31Increased serum pyruvate (HP:0003542)3.03130472
32Abnormality of glycolysis (HP:0004366)3.03130472
33Ragged-red muscle fibers (HP:0003200)3.02950796
34Calf muscle hypertrophy (HP:0008981)3.00916700
35Abnormality of skeletal muscle fiber size (HP:0012084)2.89206223
36Progressive muscle weakness (HP:0003323)2.88866041
37Increased muscle lipid content (HP:0009058)2.85674866
38Palpitations (HP:0001962)2.85202787
39Hyperammonemia (HP:0001987)2.83005402
40Muscle hypertrophy of the lower extremities (HP:0008968)2.82942535
41Abnormality of fatty-acid metabolism (HP:0004359)2.75649895
42Hypoglycemic coma (HP:0001325)2.74766916
43Increased intramyocellular lipid droplets (HP:0012240)2.72918264
44Conjunctival hamartoma (HP:0100780)2.70902223
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68865721
46Dicarboxylic aciduria (HP:0003215)2.68865721
47Respiratory failure (HP:0002878)2.66926237
48Lower limb amyotrophy (HP:0007210)2.66700489
49Cholecystitis (HP:0001082)2.66519757
50Abnormal gallbladder physiology (HP:0012438)2.66519757
51Myotonia (HP:0002486)2.60703918
52Exercise intolerance (HP:0003546)2.58539867
53Achilles tendon contracture (HP:0001771)2.57252640
54Prolonged QT interval (HP:0001657)2.57019275
55Abnormality of the calf musculature (HP:0001430)2.53106100
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52679212
57Abnormality of the Achilles tendon (HP:0005109)2.52485351
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51661794
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51661794
60Abnormality of glycolipid metabolism (HP:0010969)2.51038953
61Abnormality of liposaccharide metabolism (HP:0010968)2.51038953
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.51038953
63Rhabdomyolysis (HP:0003201)2.50893989
64Dysmetric saccades (HP:0000641)2.47331739
65Increased variability in muscle fiber diameter (HP:0003557)2.45804129
66Progressive external ophthalmoplegia (HP:0000590)2.45767167
67Increased serum lactate (HP:0002151)2.43759950
68Ventricular tachycardia (HP:0004756)2.40867529
69Cholelithiasis (HP:0001081)2.39174526
70Lethargy (HP:0001254)2.38053446
71Atrial fibrillation (HP:0005110)2.37233959
72Vertebral compression fractures (HP:0002953)2.32709301
73Neoplasm of the peripheral nervous system (HP:0100007)2.32616894
74Hyporeflexia of lower limbs (HP:0002600)2.32174613
75Hyperventilation (HP:0002883)2.31908279
76Supraventricular tachycardia (HP:0004755)2.31569321
77Hyperglycinuria (HP:0003108)2.30755722
78Anxiety (HP:0000739)2.30236922
79Abnormal gallbladder morphology (HP:0012437)2.28856697
80Systemic lupus erythematosus (HP:0002725)2.28855343
81Abnormality of serine family amino acid metabolism (HP:0010894)2.28713678
82Abnormality of glycine metabolism (HP:0010895)2.28713678
83Fatigue (HP:0012378)2.27794561
84Primary atrial arrhythmia (HP:0001692)2.25765320
85Leukodystrophy (HP:0002415)2.25590157
86CNS demyelination (HP:0007305)2.25483499
87Supraventricular arrhythmia (HP:0005115)2.23836236
88Esophageal neoplasm (HP:0100751)2.23608658
89Neoplasm of head and neck (HP:0012288)2.23608658
90Atonic seizures (HP:0010819)2.23187195
91Muscle fiber splitting (HP:0003555)2.22526737
92Muscle stiffness (HP:0003552)2.22006171
93Abnormality of alanine metabolism (HP:0010916)2.21835575
94Hyperalaninemia (HP:0003348)2.21835575
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21835575
96Syncope (HP:0001279)2.20399143
97Intrahepatic cholestasis (HP:0001406)2.20339506
98EMG: myopathic abnormalities (HP:0003458)2.17679998
99Emotional lability (HP:0000712)2.16736996
100Optic disc pallor (HP:0000543)2.16552486
101Deep venous thrombosis (HP:0002625)2.16247860
102Ventricular fibrillation (HP:0001663)2.15357418
103Cerebral inclusion bodies (HP:0100314)2.14715443
104Lipoatrophy (HP:0100578)2.13295189
105Lipid accumulation in hepatocytes (HP:0006561)2.12004019
106Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11417781
107Visual hallucinations (HP:0002367)2.11064525
108Difficulty running (HP:0009046)2.10093534
109Cerebral hemorrhage (HP:0001342)2.09679620
110Vomiting (HP:0002013)2.07685331
111Asymmetric septal hypertrophy (HP:0001670)2.06848019
112Metabolic acidosis (HP:0001942)2.06148213
113Foot dorsiflexor weakness (HP:0009027)2.04657197
114Xanthomatosis (HP:0000991)2.04006027
115Difficulty climbing stairs (HP:0003551)2.02752781
116Athetosis (HP:0002305)2.02259866
117Abnormal EKG (HP:0003115)2.02095051
118Subaortic stenosis (HP:0001682)2.01736773
119Abnormality of the left ventricular outflow tract (HP:0011103)2.01736773
120Generalized tonic-clonic seizures (HP:0002069)2.01585274
121Focal seizures (HP:0007359)2.01471784
122Poor eye contact (HP:0000817)2.01070599
123Increased cerebral lipofuscin (HP:0011813)2.00499871
124Bulbar palsy (HP:0001283)1.99945976
125Neck muscle weakness (HP:0000467)1.97750331
126Dilated cardiomyopathy (HP:0001644)1.97487549
127Hyperglycinemia (HP:0002154)1.97293312
128Bundle branch block (HP:0011710)1.97019569
129Neurofibrillary tangles (HP:0002185)1.96617359
130Neuronal loss in central nervous system (HP:0002529)1.96396404
131Epileptic encephalopathy (HP:0200134)1.96319456
132Neoplasm of the adrenal gland (HP:0100631)1.95271066
133Abnormal social behavior (HP:0012433)1.94699419
134Impaired social interactions (HP:0000735)1.94699419
135Ventricular arrhythmia (HP:0004308)1.94405159
136Abnormality of the foot musculature (HP:0001436)1.92918274
137Gout (HP:0001997)1.92806540
138Axonal loss (HP:0003447)1.92422740
139Methylmalonic aciduria (HP:0012120)1.90692727
140Abnormality of complement system (HP:0005339)1.90546613
141Upper motor neuron abnormality (HP:0002127)1.88853091
142Myocardial infarction (HP:0001658)1.87862395
143Supranuclear gaze palsy (HP:0000605)1.87108317
144Termporal pattern (HP:0011008)1.85923091
145Insidious onset (HP:0003587)1.85923091
146Complement deficiency (HP:0004431)1.77187982
147Hyperacusis (HP:0010780)1.75817533
148Apathy (HP:0000741)1.73818667
149Distal upper limb amyotrophy (HP:0007149)1.72991195
150Upper limb amyotrophy (HP:0009129)1.72991195
151Dysostosis multiplex (HP:0000943)1.72981645
152Multiple enchondromatosis (HP:0005701)1.72750595
153Reticulocytosis (HP:0001923)1.72633157
154Personality changes (HP:0000751)1.72392936
155Loss of speech (HP:0002371)1.71070312
156Purpura (HP:0000979)1.70254425
157Scanning speech (HP:0002168)1.69869476
158Tetraplegia (HP:0002445)1.69487624
159Frequent falls (HP:0002359)1.67549845
160Polygenic inheritance (HP:0010982)1.67487050
161Round ear (HP:0100830)1.65611347
162Mildly elevated creatine phosphokinase (HP:0008180)1.65485790
163Increased serum ferritin (HP:0003281)1.64993041
164Atrioventricular block (HP:0001678)1.64778198
165Polycythemia (HP:0001901)1.64507803
166Abnormal atrioventricular conduction (HP:0005150)1.63174094
167Diminished motivation (HP:0000745)1.63115074
168Amyloidosis (HP:0011034)1.61930925
169Abnormal large intestine physiology (HP:0012700)1.61572147
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.61537517
171Insomnia (HP:0100785)1.60409339
172Ulnar deviation of the wrist (HP:0003049)1.60353016
173Peripheral hypomyelination (HP:0007182)1.60169491
174EMG: neuropathic changes (HP:0003445)1.60123659
175Ankyloglossia (HP:0010296)1.60081687
176Slow saccadic eye movements (HP:0000514)1.58225236
177Spinal rigidity (HP:0003306)1.58090571
178Bowel incontinence (HP:0002607)1.57982796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.73550319
2PRPF4B3.37308506
3IRAK33.01298626
4EPHA42.98714418
5TRIB32.64280141
6PHKG22.54175322
7PHKG12.54175322
8RIPK12.46801564
9PKN22.45524607
10NEK12.37878735
11ICK2.31949048
12MYLK2.31793933
13LMTK22.24291169
14PDK32.20392087
15PDK42.20392087
16MAP3K122.19557562
17ARAF2.17689235
18CAMKK22.17139269
19SMG11.96486741
20NTRK31.93348147
21DAPK11.91466998
22PINK11.90423887
23CDK191.90338962
24MINK11.88994577
25MAP3K131.88793470
26EEF2K1.85103008
27DAPK21.80246260
28MAP3K41.76066256
29MAP2K41.71149044
30CAMKK11.69921355
31OBSCN1.60749374
32TTN1.54803532
33SCYL21.54381710
34MAP2K71.52391368
35NME11.42868863
36MAP3K91.42633402
37CDK121.39407195
38MAPKAPK31.38858386
39LATS21.36654853
40CASK1.36297413
41PIK3CG1.35943555
42KSR21.33235847
43MAP3K61.32818077
44TAOK21.31417107
45FGFR41.29759390
46MAP3K141.29388349
47KDR1.21474075
48DAPK31.20833950
49TESK11.18769795
50GRK51.16938771
51CCNB11.15307511
52TIE11.12613342
53MOS1.04728971
54NTRK11.03868724
55PDK21.03847699
56ILK1.03312081
57TBK11.03228227
58PDGFRA1.02900413
59MUSK1.02820925
60STK161.00990937
61MAPK120.99302519
62PIM20.99253341
63MAP3K110.98245768
64PAK60.97341812
65LIMK10.96997633
66PRKCG0.92126326
67MAP3K30.91750722
68CAMK2D0.90815019
69SIK20.90042029
70MAP3K80.89856852
71CAMK10.89078954
72FLT30.88959963
73ERN10.88038515
74CAMK2A0.87679444
75CDK50.84523699
76EPHB10.84085341
77IRAK20.83617391
78WNK40.82850308
79PAK30.82357365
80MAP3K100.82180099
81ALK0.81745054
82MARK20.81739686
83OXSR10.80391795
84CAMK2G0.80376400
85FES0.79085906
86ZAP700.78018380
87RIPK40.77669907
88SIK10.75872745
89PDPK10.74196313
90PIK3CA0.74152773
91PAK40.71988307
92NTRK20.71450659
93BRSK10.71211389
94PTK2B0.70776768
95UHMK10.70769315
96CAMK2B0.69812036
97CDK40.69773900
98PBK0.68783456
99MAPK110.65599683
100RAF10.65570475
101TAOK10.65549606
102CAMK40.64212450
103PDK10.64052678
104MTOR0.62954774
105MAP3K70.60424104
106MAP2K20.58969597
107PRKCH0.57530999
108CAMK1D0.57341264
109DMPK0.56627310
110TYK20.56560475
111IRAK40.56032917
112MAPKAPK50.54763847
113PRKD30.54566364
114MAP3K10.53518279
115CDK180.52579803
116CDK150.52274585
117PRKD10.51702725
118CDK60.51701171
119MAP2K60.51667799
120GRK60.51357989
121BRAF0.50632393
122RET0.50307922
123PRKD20.50171527
124MATK0.50166901
125MARK10.49927231
126ABL20.49896297
127PRKACG0.49160218
128NME20.46442427
129BLK0.46046050
130CDK140.46016136
131SGK4940.45815393
132SGK2230.45815393
133PRKACA0.45673572
134CDK11A0.44873480
135GRK70.43708140
136KIT0.43347717
137PTK60.43193781
138KSR10.41455939
139MAP2K10.41316723
140SIK30.41242193
141MAPK40.40872653
142RPS6KA20.40246373
143TESK20.39968205
144PTK20.38630359
145NEK90.36938246
146AKT20.36131731
147JAK20.35795943
148PRKG20.35313896
149TSSK60.35310724
150ROCK20.35239454
151MAP2K30.34607091
152MST1R0.34310153
153MAP3K50.34176669
154MAP4K10.33505230
155MAPK100.33343549
156CDK70.33190191
157RPS6KC10.32296628
158RPS6KL10.32296628

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.34522273
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55976192
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.55233581
4Oxidative phosphorylation_Homo sapiens_hsa001903.18024246
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.03542362
6Parkinsons disease_Homo sapiens_hsa050122.94349722
7Propanoate metabolism_Homo sapiens_hsa006402.51322840
8Other glycan degradation_Homo sapiens_hsa005112.40746545
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34243346
10Pyruvate metabolism_Homo sapiens_hsa006202.31792841
11Fatty acid degradation_Homo sapiens_hsa000712.24305381
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24009606
13Nitrogen metabolism_Homo sapiens_hsa009102.22153127
14Cardiac muscle contraction_Homo sapiens_hsa042602.20122840
15Prion diseases_Homo sapiens_hsa050202.19361095
16Alzheimers disease_Homo sapiens_hsa050102.17720680
17Carbon metabolism_Homo sapiens_hsa012002.13335037
18Butanoate metabolism_Homo sapiens_hsa006502.01501064
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.98649555
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91587194
21Arginine biosynthesis_Homo sapiens_hsa002201.83006206
22Synaptic vesicle cycle_Homo sapiens_hsa047211.77789042
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71846357
24Fatty acid metabolism_Homo sapiens_hsa012121.70097872
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69405155
26Biosynthesis of amino acids_Homo sapiens_hsa012301.66272298
27Chronic myeloid leukemia_Homo sapiens_hsa052201.66093496
28Non-small cell lung cancer_Homo sapiens_hsa052231.65010802
29Huntingtons disease_Homo sapiens_hsa050161.57118496
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53899202
31VEGF signaling pathway_Homo sapiens_hsa043701.52034690
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50519135
33Acute myeloid leukemia_Homo sapiens_hsa052211.48323659
34Bladder cancer_Homo sapiens_hsa052191.48203671
35Fatty acid elongation_Homo sapiens_hsa000621.45880702
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45214702
37Tryptophan metabolism_Homo sapiens_hsa003801.45101837
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38634682
39Pancreatic cancer_Homo sapiens_hsa052121.26582675
40Glioma_Homo sapiens_hsa052141.22920355
41Collecting duct acid secretion_Homo sapiens_hsa049661.22363070
42Peroxisome_Homo sapiens_hsa041461.15615251
43* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14450388
44Nicotine addiction_Homo sapiens_hsa050331.13971892
45GABAergic synapse_Homo sapiens_hsa047271.12354190
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.09868506
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09203103
48Osteoclast differentiation_Homo sapiens_hsa043801.08569264
49B cell receptor signaling pathway_Homo sapiens_hsa046621.08297974
50Phenylalanine metabolism_Homo sapiens_hsa003601.07093800
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07026040
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06916593
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06789086
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.05898089
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03883090
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.00355457
57beta-Alanine metabolism_Homo sapiens_hsa004100.99551983
58Olfactory transduction_Homo sapiens_hsa047400.99090422
59Shigellosis_Homo sapiens_hsa051310.98861139
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98341063
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96819689
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96678111
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96496281
64PPAR signaling pathway_Homo sapiens_hsa033200.96461760
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91382220
66Circadian entrainment_Homo sapiens_hsa047130.89888501
67Bile secretion_Homo sapiens_hsa049760.89752161
68Lysosome_Homo sapiens_hsa041420.89567817
69ErbB signaling pathway_Homo sapiens_hsa040120.86712927
70GnRH signaling pathway_Homo sapiens_hsa049120.84435002
71Fructose and mannose metabolism_Homo sapiens_hsa000510.83309535
72Morphine addiction_Homo sapiens_hsa050320.81031484
73Renal cell carcinoma_Homo sapiens_hsa052110.79642448
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79508517
75Dilated cardiomyopathy_Homo sapiens_hsa054140.79182887
76Sulfur metabolism_Homo sapiens_hsa009200.78864852
77Pertussis_Homo sapiens_hsa051330.78816829
78Vibrio cholerae infection_Homo sapiens_hsa051100.78709058
79Dopaminergic synapse_Homo sapiens_hsa047280.78082248
80Arginine and proline metabolism_Homo sapiens_hsa003300.76409540
81Insulin secretion_Homo sapiens_hsa049110.76289352
82AMPK signaling pathway_Homo sapiens_hsa041520.75098894
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.74573624
84Salmonella infection_Homo sapiens_hsa051320.74452279
85Endometrial cancer_Homo sapiens_hsa052130.74336612
86Amphetamine addiction_Homo sapiens_hsa050310.74096596
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73830874
88HIF-1 signaling pathway_Homo sapiens_hsa040660.71858185
89Tuberculosis_Homo sapiens_hsa051520.71682066
90Long-term potentiation_Homo sapiens_hsa047200.71452368
91mTOR signaling pathway_Homo sapiens_hsa041500.71057611
92Estrogen signaling pathway_Homo sapiens_hsa049150.70868136
93Tyrosine metabolism_Homo sapiens_hsa003500.70314410
94Insulin resistance_Homo sapiens_hsa049310.69784310
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68947341
96Starch and sucrose metabolism_Homo sapiens_hsa005000.67426223
97Amoebiasis_Homo sapiens_hsa051460.67406464
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66506341
99Leishmaniasis_Homo sapiens_hsa051400.66115704
100Glutamatergic synapse_Homo sapiens_hsa047240.65410562
101Apoptosis_Homo sapiens_hsa042100.65198446
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63730615
103Prolactin signaling pathway_Homo sapiens_hsa049170.63419688
104Hepatitis B_Homo sapiens_hsa051610.63160758
105Gastric acid secretion_Homo sapiens_hsa049710.62310406
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61718754
107Thyroid cancer_Homo sapiens_hsa052160.61563431
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61434360
109DNA replication_Homo sapiens_hsa030300.60059408
110Influenza A_Homo sapiens_hsa051640.59864000
111Glucagon signaling pathway_Homo sapiens_hsa049220.59014514
112Calcium signaling pathway_Homo sapiens_hsa040200.58903612
113Histidine metabolism_Homo sapiens_hsa003400.57897958
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57646516
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57128785
116Salivary secretion_Homo sapiens_hsa049700.56794535
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55472282
118Sulfur relay system_Homo sapiens_hsa041220.55199993
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54859646
120Fat digestion and absorption_Homo sapiens_hsa049750.54828624
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54364332
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53730286
123Toxoplasmosis_Homo sapiens_hsa051450.52925747
124Endocytosis_Homo sapiens_hsa041440.52865104
125Metabolic pathways_Homo sapiens_hsa011000.52326044
126Legionellosis_Homo sapiens_hsa051340.51486746
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.50460131
128Cholinergic synapse_Homo sapiens_hsa047250.49963523
129Renin secretion_Homo sapiens_hsa049240.49282988
130Pentose phosphate pathway_Homo sapiens_hsa000300.47683325
131Caffeine metabolism_Homo sapiens_hsa002320.47601158
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.47154564
133Inositol phosphate metabolism_Homo sapiens_hsa005620.46972356
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46489731
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46427425
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.46350789
137Hepatitis C_Homo sapiens_hsa051600.46212957
138Oxytocin signaling pathway_Homo sapiens_hsa049210.45232012
139Staphylococcus aureus infection_Homo sapiens_hsa051500.45205979
140Viral carcinogenesis_Homo sapiens_hsa052030.44455786
141Cocaine addiction_Homo sapiens_hsa050300.43919901
142Galactose metabolism_Homo sapiens_hsa000520.43112351
143Glycerolipid metabolism_Homo sapiens_hsa005610.42867101
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41582822
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41370877
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40156822
147Fatty acid biosynthesis_Homo sapiens_hsa000610.39899575
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38724818
149Chemical carcinogenesis_Homo sapiens_hsa052040.38204091
150Pancreatic secretion_Homo sapiens_hsa049720.38150514
151Complement and coagulation cascades_Homo sapiens_hsa046100.35278939
152Taste transduction_Homo sapiens_hsa047420.33024511
153Folate biosynthesis_Homo sapiens_hsa007900.32524142
154Serotonergic synapse_Homo sapiens_hsa047260.32105463
155Gap junction_Homo sapiens_hsa045400.31802337
156Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30211442
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.28184071
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27741970
159Insulin signaling pathway_Homo sapiens_hsa049100.26901863
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.25614025
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24571955
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22879894
163cAMP signaling pathway_Homo sapiens_hsa040240.22381174

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