

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.15153695 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.37121288 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.37121288 |
| 4 | DNA deamination (GO:0045006) | 6.22796349 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 5.24861391 |
| 6 | respiratory electron transport chain (GO:0022904) | 5.20709095 |
| 7 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.20359946 |
| 8 | ribosomal small subunit assembly (GO:0000028) | 5.17535482 |
| 9 | electron transport chain (GO:0022900) | 5.08243825 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.02241104 |
| 11 | viral transcription (GO:0019083) | 4.61979668 |
| 12 | proteasome assembly (GO:0043248) | 4.58250658 |
| 13 | formation of translation preinitiation complex (GO:0001731) | 4.56810484 |
| 14 | translational termination (GO:0006415) | 4.44858668 |
| 15 | protein complex biogenesis (GO:0070271) | 4.35074491 |
| 16 | ribosomal small subunit biogenesis (GO:0042274) | 4.31077068 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.22984510 |
| 18 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.16200200 |
| 19 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.15510257 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 4.15510257 |
| 21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.15510257 |
| 22 | maturation of SSU-rRNA (GO:0030490) | 4.14645125 |
| 23 | translational elongation (GO:0006414) | 4.13946105 |
| 24 | cotranslational protein targeting to membrane (GO:0006613) | 4.02323889 |
| 25 | protein targeting to ER (GO:0045047) | 4.02217926 |
| 26 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.02079851 |
| 27 | establishment of integrated proviral latency (GO:0075713) | 4.00696758 |
| 28 | protein targeting to membrane (GO:0006612) | 3.99600874 |
| 29 | ribosomal large subunit biogenesis (GO:0042273) | 3.94490249 |
| 30 | translational initiation (GO:0006413) | 3.93260891 |
| 31 | * protein targeting to mitochondrion (GO:0006626) | 3.85927209 |
| 32 | protein localization to endoplasmic reticulum (GO:0070972) | 3.82064133 |
| 33 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.81855424 |
| 34 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.78275230 |
| 35 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.75563104 |
| 36 | sequestering of actin monomers (GO:0042989) | 3.74712433 |
| 37 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.74481192 |
| 38 | translation (GO:0006412) | 3.73347530 |
| 39 | ribosome biogenesis (GO:0042254) | 3.70830518 |
| 40 | ATP biosynthetic process (GO:0006754) | 3.68819170 |
| 41 | mRNA catabolic process (GO:0006402) | 3.66121106 |
| 42 | spliceosomal snRNP assembly (GO:0000387) | 3.61837486 |
| 43 | viral life cycle (GO:0019058) | 3.60890734 |
| 44 | rRNA modification (GO:0000154) | 3.60843817 |
| 45 | * establishment of protein localization to mitochondrion (GO:0072655) | 3.60528434 |
| 46 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.58084946 |
| 47 | DNA strand elongation (GO:0022616) | 3.57820617 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.57354837 |
| 49 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.57354837 |
| 50 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.55372125 |
| 51 | cellular protein complex disassembly (GO:0043624) | 3.54116198 |
| 52 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.53735178 |
| 53 | pseudouridine synthesis (GO:0001522) | 3.52528781 |
| 54 | * protein localization to mitochondrion (GO:0070585) | 3.51621443 |
| 55 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.50928597 |
| 56 | cullin deneddylation (GO:0010388) | 3.49484544 |
| 57 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.47538825 |
| 58 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.46197829 |
| 59 | telomere maintenance via recombination (GO:0000722) | 3.43864392 |
| 60 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.43065654 |
| 61 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.42538060 |
| 62 | RNA catabolic process (GO:0006401) | 3.42038529 |
| 63 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.41871731 |
| 64 | negative regulation of ligase activity (GO:0051352) | 3.41871731 |
| 65 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.41254797 |
| 66 | protein deneddylation (GO:0000338) | 3.41202511 |
| 67 | respiratory chain complex IV assembly (GO:0008535) | 3.40774036 |
| 68 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.40027727 |
| 69 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.40027727 |
| 70 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.40027727 |
| 71 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.39534070 |
| 72 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.39534070 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.38069689 |
| 74 | protein neddylation (GO:0045116) | 3.36558028 |
| 75 | CENP-A containing nucleosome assembly (GO:0034080) | 3.36553574 |
| 76 | DNA replication checkpoint (GO:0000076) | 3.36079951 |
| 77 | inner mitochondrial membrane organization (GO:0007007) | 3.34738274 |
| 78 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.34587276 |
| 79 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.34587276 |
| 80 | establishment of viral latency (GO:0019043) | 3.34393925 |
| 81 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.34267745 |
| 82 | rRNA processing (GO:0006364) | 3.33500595 |
| 83 | chromatin remodeling at centromere (GO:0031055) | 3.33050859 |
| 84 | regulation of mitochondrial translation (GO:0070129) | 3.32714016 |
| 85 | cytochrome complex assembly (GO:0017004) | 3.30278257 |
| 86 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.29556900 |
| 87 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.29247864 |
| 88 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.28060849 |
| 89 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.27817853 |
| 90 | cellular component biogenesis (GO:0044085) | 3.27168327 |
| 91 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.25564052 |
| 92 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.23867013 |
| 93 | nucleobase biosynthetic process (GO:0046112) | 3.20965767 |
| 94 | aerobic respiration (GO:0009060) | 3.20172789 |
| 95 | rRNA metabolic process (GO:0016072) | 3.18265450 |
| 96 | spliceosomal complex assembly (GO:0000245) | 3.17355764 |
| 97 | hydrogen ion transmembrane transport (GO:1902600) | 3.16736137 |
| 98 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.14370180 |
| 99 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.14370180 |
| 100 | GDP-mannose metabolic process (GO:0019673) | 3.14050433 |
| 101 | protein complex disassembly (GO:0043241) | 3.13217673 |
| 102 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.11594258 |
| 103 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.11092270 |
| 104 | 7-methylguanosine mRNA capping (GO:0006370) | 3.11056844 |
| 105 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.10597938 |
| 106 | * mitochondrial transport (GO:0006839) | 3.10449782 |
| 107 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.06229226 |
| 108 | purine nucleobase biosynthetic process (GO:0009113) | 3.02800281 |
| 109 | DNA replication initiation (GO:0006270) | 3.02401481 |
| 110 | amino acid salvage (GO:0043102) | 3.01539821 |
| 111 | L-methionine salvage (GO:0071267) | 3.01539821 |
| 112 | L-methionine biosynthetic process (GO:0071265) | 3.01539821 |
| 113 | mitotic recombination (GO:0006312) | 3.00189164 |
| 114 | viral mRNA export from host cell nucleus (GO:0046784) | 2.99277747 |
| 115 | 7-methylguanosine RNA capping (GO:0009452) | 2.99137050 |
| 116 | RNA capping (GO:0036260) | 2.99137050 |
| 117 | macromolecular complex disassembly (GO:0032984) | 2.99082647 |
| 118 | positive regulation of ligase activity (GO:0051351) | 2.97618302 |
| 119 | telomere maintenance via telomere lengthening (GO:0010833) | 2.96185005 |
| 120 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.92991706 |
| 121 | proline biosynthetic process (GO:0006561) | 2.92065609 |
| 122 | positive regulation of cell cycle arrest (GO:0071158) | 2.92031873 |
| 123 | ribosome assembly (GO:0042255) | 2.81952439 |
| 124 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.80816890 |
| 125 | oxidative phosphorylation (GO:0006119) | 2.80624136 |
| 126 | maturation of 5.8S rRNA (GO:0000460) | 2.79291074 |
| 127 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.77927715 |
| 128 | transcription from RNA polymerase I promoter (GO:0006360) | 2.76959103 |
| 129 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.76400637 |
| 130 | transcription from mitochondrial promoter (GO:0006390) | 2.76041212 |
| 131 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.75577868 |
| 132 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.74692839 |
| 133 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.74692839 |
| 134 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.73117894 |
| 135 | regulation of protein heterodimerization activity (GO:0043497) | 2.72364541 |
| 136 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.72109689 |
| 137 | IMP biosynthetic process (GO:0006188) | 2.69840019 |
| 138 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.69826864 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.57174821 |
| 2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.01696821 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.87433074 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.37121388 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.26799723 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.18890455 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.08227366 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.05066502 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.96372217 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88848591 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79870054 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.64981010 |
| 13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.60183617 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.36426335 |
| 15 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.30374667 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.20753484 |
| 17 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.14500864 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.12727629 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.09365649 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.08280933 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.02953134 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01780368 |
| 23 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.99993265 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.99750452 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.96132090 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.96047934 |
| 27 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.92751213 |
| 28 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.90663946 |
| 29 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.88468600 |
| 30 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.85800176 |
| 31 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.82764861 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.78189878 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.74326680 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72193962 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.68294447 |
| 36 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62756196 |
| 37 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.61516903 |
| 38 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.60790027 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59375777 |
| 40 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59098086 |
| 41 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.58094148 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57885574 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.51433663 |
| 44 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51401379 |
| 45 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.48492754 |
| 46 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.47814557 |
| 47 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.43722283 |
| 48 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.40324725 |
| 49 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.39426159 |
| 50 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.39284391 |
| 51 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.38146065 |
| 52 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.37658297 |
| 53 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.37658297 |
| 54 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.37658297 |
| 55 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.35793741 |
| 56 | MYC_22102868_ChIP-Seq_BL_Human | 1.35540202 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.33474754 |
| 58 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.33115314 |
| 59 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.32153446 |
| 60 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.31658175 |
| 61 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29727734 |
| 62 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.29195613 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28967545 |
| 64 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28729923 |
| 65 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.27743167 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.27715798 |
| 67 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.25264300 |
| 68 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.25148169 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25013446 |
| 70 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24645969 |
| 71 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.24238015 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.22377027 |
| 73 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.20855289 |
| 74 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.20230965 |
| 75 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.19396417 |
| 76 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.16920348 |
| 77 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.16742607 |
| 78 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.15095527 |
| 79 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.13811257 |
| 80 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13567835 |
| 81 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13024575 |
| 82 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.12774612 |
| 83 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.11973036 |
| 84 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.10246876 |
| 85 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.09669879 |
| 86 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.09641986 |
| 87 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09487155 |
| 88 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.09137731 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.07903580 |
| 90 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07143385 |
| 91 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.06882039 |
| 92 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.06288207 |
| 93 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06011480 |
| 94 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.05728300 |
| 95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.04162794 |
| 96 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.03131651 |
| 97 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.01995403 |
| 98 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.01548829 |
| 99 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.99953470 |
| 100 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.97144442 |
| 101 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.95534279 |
| 102 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.95176633 |
| 103 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.94868934 |
| 104 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.94139235 |
| 105 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.93349626 |
| 106 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.93331282 |
| 107 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93126070 |
| 108 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92021477 |
| 109 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.89626004 |
| 110 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.89621050 |
| 111 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.88425699 |
| 112 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88257531 |
| 113 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87386440 |
| 114 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82091539 |
| 115 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80935145 |
| 116 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.77384629 |
| 117 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.74651036 |
| 118 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.74536340 |
| 119 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.72146949 |
| 120 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.70531618 |
| 121 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.70522999 |
| 122 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.69439909 |
| 123 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.69209964 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.80709518 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.90270543 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.58742514 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.05182098 |
| 5 | MP0003186_abnormal_redox_activity | 3.01831885 |
| 6 | MP0003077_abnormal_cell_cycle | 2.99483496 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.66447271 |
| 8 | MP0000372_irregular_coat_pigmentation | 2.60203941 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.45987951 |
| 10 | MP0008058_abnormal_DNA_repair | 2.32311100 |
| 11 | MP0009697_abnormal_copulation | 2.28924766 |
| 12 | MP0002938_white_spotting | 2.22800276 |
| 13 | MP0008007_abnormal_cellular_replicative | 2.20575079 |
| 14 | MP0008057_abnormal_DNA_replication | 2.10007719 |
| 15 | MP0005408_hypopigmentation | 2.09774891 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 2.07103666 |
| 17 | MP0003786_premature_aging | 2.04665634 |
| 18 | MP0002132_abnormal_respiratory_system | 1.94799822 |
| 19 | MP0003436_decreased_susceptibility_to | 1.94496592 |
| 20 | MP0006036_abnormal_mitochondrial_physio | 1.90382242 |
| 21 | MP0008995_early_reproductive_senescence | 1.83068752 |
| 22 | MP0004147_increased_porphyrin_level | 1.78693353 |
| 23 | MP0001853_heart_inflammation | 1.74849979 |
| 24 | MP0001835_abnormal_antigen_presentation | 1.72105040 |
| 25 | MP0010030_abnormal_orbit_morphology | 1.70835508 |
| 26 | MP0000858_altered_metastatic_potential | 1.68326297 |
| 27 | MP0003718_maternal_effect | 1.67487091 |
| 28 | MP0000490_abnormal_crypts_of | 1.66349973 |
| 29 | MP0001529_abnormal_vocalization | 1.63634604 |
| 30 | MP0003136_yellow_coat_color | 1.58002976 |
| 31 | MP0000350_abnormal_cell_proliferation | 1.54433871 |
| 32 | MP0009785_altered_susceptibility_to | 1.49987568 |
| 33 | MP0009840_abnormal_foam_cell | 1.48750893 |
| 34 | MP0000313_abnormal_cell_death | 1.46547032 |
| 35 | MP0001730_embryonic_growth_arrest | 1.45806760 |
| 36 | MP0002653_abnormal_ependyma_morphology | 1.44866131 |
| 37 | MP0001293_anophthalmia | 1.41805890 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.41757465 |
| 39 | MP0003656_abnormal_erythrocyte_physiolo | 1.39971043 |
| 40 | MP0002163_abnormal_gland_morphology | 1.38851440 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.37986741 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.37986741 |
| 43 | MP0003011_delayed_dark_adaptation | 1.37598049 |
| 44 | MP0002148_abnormal_hypersensitivity_rea | 1.34076172 |
| 45 | MP0002210_abnormal_sex_determination | 1.32260975 |
| 46 | MP0006082_CNS_inflammation | 1.32059415 |
| 47 | MP0000358_abnormal_cell_content/ | 1.31519959 |
| 48 | MP0008789_abnormal_olfactory_epithelium | 1.31279447 |
| 49 | MP0006035_abnormal_mitochondrial_morpho | 1.29385293 |
| 50 | MP0003123_paternal_imprinting | 1.28927191 |
| 51 | MP0002837_dystrophic_cardiac_calcinosis | 1.26078692 |
| 52 | MP0005025_abnormal_response_to | 1.25827272 |
| 53 | MP0000689_abnormal_spleen_morphology | 1.24143392 |
| 54 | MP0004133_heterotaxia | 1.22313750 |
| 55 | MP0002722_abnormal_immune_system | 1.20680598 |
| 56 | MP0002095_abnormal_skin_pigmentation | 1.20653009 |
| 57 | MP0002405_respiratory_system_inflammati | 1.20401976 |
| 58 | MP0002396_abnormal_hematopoietic_system | 1.18568539 |
| 59 | MP0010352_gastrointestinal_tract_polyps | 1.17405978 |
| 60 | MP0001764_abnormal_homeostasis | 1.16219292 |
| 61 | MP0000685_abnormal_immune_system | 1.14105113 |
| 62 | MP0005319_abnormal_enzyme/_coenzyme | 1.13890742 |
| 63 | MP0005075_abnormal_melanosome_morpholog | 1.13857891 |
| 64 | MP0005000_abnormal_immune_tolerance | 1.13615007 |
| 65 | MP0002398_abnormal_bone_marrow | 1.12673759 |
| 66 | MP0002080_prenatal_lethality | 1.12120324 |
| 67 | MP0001929_abnormal_gametogenesis | 1.09724999 |
| 68 | MP0001697_abnormal_embryo_size | 1.09599934 |
| 69 | MP0001672_abnormal_embryogenesis/_devel | 1.09179011 |
| 70 | MP0005380_embryogenesis_phenotype | 1.09179011 |
| 71 | MP0008875_abnormal_xenobiotic_pharmacok | 1.08167880 |
| 72 | MP0002429_abnormal_blood_cell | 1.07772259 |
| 73 | MP0005671_abnormal_response_to | 1.07627218 |
| 74 | MP0006072_abnormal_retinal_apoptosis | 1.06980445 |
| 75 | MP0000750_abnormal_muscle_regeneration | 1.05936644 |
| 76 | MP0003763_abnormal_thymus_physiology | 1.04960955 |
| 77 | MP0001905_abnormal_dopamine_level | 1.03079037 |
| 78 | MP0008469_abnormal_protein_level | 1.03034928 |
| 79 | MP0002139_abnormal_hepatobiliary_system | 1.01715854 |
| 80 | MP0006292_abnormal_olfactory_placode | 1.01143192 |
| 81 | MP0001145_abnormal_male_reproductive | 1.00885386 |
| 82 | MP0005266_abnormal_metabolism | 1.00551289 |
| 83 | MP0000343_altered_response_to | 0.99428004 |
| 84 | MP0001881_abnormal_mammary_gland | 0.98058398 |
| 85 | MP0001542_abnormal_bone_strength | 0.97999990 |
| 86 | MP0003984_embryonic_growth_retardation | 0.97873864 |
| 87 | MP0003941_abnormal_skin_development | 0.97197800 |
| 88 | MP0003567_abnormal_fetal_cardiomyocyte | 0.96804783 |
| 89 | MP0002452_abnormal_antigen_presenting | 0.96315715 |
| 90 | MP0001800_abnormal_humoral_immune | 0.96171297 |
| 91 | MP0002088_abnormal_embryonic_growth/wei | 0.95709784 |
| 92 | MP0000716_abnormal_immune_system | 0.95243873 |
| 93 | MP0005084_abnormal_gallbladder_morpholo | 0.95122443 |
| 94 | MP0005023_abnormal_wound_healing | 0.94033515 |
| 95 | MP0002723_abnormal_immune_serum | 0.93161318 |
| 96 | MP0000653_abnormal_sex_gland | 0.91937338 |
| 97 | MP0001845_abnormal_inflammatory_respons | 0.91401279 |
| 98 | MP0001819_abnormal_immune_cell | 0.89666605 |
| 99 | MP0002420_abnormal_adaptive_immunity | 0.89252851 |
| 100 | MP0002419_abnormal_innate_immunity | 0.89024253 |
| 101 | MP0003724_increased_susceptibility_to | 0.87841608 |
| 102 | MP0005332_abnormal_amino_acid | 0.87498668 |
| 103 | MP0002277_abnormal_respiratory_mucosa | 0.87372964 |
| 104 | MP0005379_endocrine/exocrine_gland_phen | 0.87319276 |
| 105 | MP0000703_abnormal_thymus_morphology | 0.87197910 |
| 106 | MP0001727_abnormal_embryo_implantation | 0.87184250 |
| 107 | MP0002160_abnormal_reproductive_system | 0.86747279 |
| 108 | MP0001346_abnormal_lacrimal_gland | 0.86316651 |
| 109 | MP0005636_abnormal_mineral_homeostasis | 0.85929847 |
| 110 | MP0009379_abnormal_foot_pigmentation | 0.85876200 |
| 111 | MP0000678_abnormal_parathyroid_gland | 0.85431465 |
| 112 | MP0000598_abnormal_liver_morphology | 0.85267240 |
| 113 | MP0010307_abnormal_tumor_latency | 0.84283263 |
| 114 | MP0005410_abnormal_fertilization | 0.83631044 |
| 115 | MP0000566_synostosis | 0.82174109 |
| 116 | MP0005389_reproductive_system_phenotype | 0.81066703 |
| 117 | MP0002085_abnormal_embryonic_tissue | 0.79773345 |
| 118 | MP0002086_abnormal_extraembryonic_tissu | 0.77689770 |
| 119 | MP0003448_altered_tumor_morphology | 0.76781129 |
| 120 | MP0002234_abnormal_pharynx_morphology | 0.74253579 |
| 121 | MP0005083_abnormal_biliary_tract | 0.73496497 |
| 122 | MP0001919_abnormal_reproductive_system | 0.73164578 |
| 123 | MP0005058_abnormal_lysosome_morphology | 0.72583625 |
| 124 | MP0009643_abnormal_urine_homeostasis | 0.71908378 |
| 125 | MP0008873_increased_physiological_sensi | 0.70868525 |
| 126 | MP0003698_abnormal_male_reproductive | 0.70704819 |
| 127 | MP0005085_abnormal_gallbladder_physiolo | 0.70210605 |
| 128 | MP0005376_homeostasis/metabolism_phenot | 0.69667810 |
| 129 | MP0009764_decreased_sensitivity_to | 0.69615799 |
| 130 | MP0009053_abnormal_anal_canal | 0.69419458 |
| 131 | MP0004808_abnormal_hematopoietic_stem | 0.69031376 |
| 132 | MP0000631_abnormal_neuroendocrine_gland | 0.68255770 |
| 133 | MP0002102_abnormal_ear_morphology | 0.68160333 |
| 134 | MP0004142_abnormal_muscle_tone | 0.68055537 |
| 135 | MP0003315_abnormal_perineum_morphology | 0.67065779 |
| 136 | MP0005499_abnormal_olfactory_system | 0.64846909 |
| 137 | MP0005394_taste/olfaction_phenotype | 0.64846909 |
| 138 | MP0002084_abnormal_developmental_patter | 0.62803866 |
| 139 | MP0003938_abnormal_ear_development | 0.62033721 |
| 140 | MP0001186_pigmentation_phenotype | 0.61829621 |
| 141 | MP0009672_abnormal_birth_weight | 0.61347651 |
| 142 | MP0002161_abnormal_fertility/fecundity | 0.59714712 |
| 143 | MP0000049_abnormal_middle_ear | 0.58282852 |
| 144 | MP0001286_abnormal_eye_development | 0.57702514 |
| 145 | MP0003121_genomic_imprinting | 0.57154323 |
| 146 | MP0005171_absent_coat_pigmentation | 0.56619157 |
| 147 | MP0005501_abnormal_skin_physiology | 0.55702211 |
| 148 | MP0002111_abnormal_tail_morphology | 0.55290552 |
| 149 | MP0001119_abnormal_female_reproductive | 0.54642087 |
| 150 | MP0003937_abnormal_limbs/digits/tail_de | 0.53150750 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.20792288 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 4.17208458 |
| 3 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.92991329 |
| 4 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.92991329 |
| 5 | Reticulocytopenia (HP:0001896) | 3.76541599 |
| 6 | Multiple enchondromatosis (HP:0005701) | 3.59896504 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.48404202 |
| 8 | Hepatic necrosis (HP:0002605) | 3.43115944 |
| 9 | Abnormality of the anterior horn cell (HP:0006802) | 3.35252161 |
| 10 | Degeneration of anterior horn cells (HP:0002398) | 3.35252161 |
| 11 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.33454258 |
| 12 | Cerebral hypomyelination (HP:0006808) | 3.23956296 |
| 13 | Respiratory difficulties (HP:0002880) | 3.21167020 |
| 14 | Mitochondrial inheritance (HP:0001427) | 3.18935920 |
| 15 | Oral leukoplakia (HP:0002745) | 3.17784291 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 3.15477754 |
| 17 | Carpal bone hypoplasia (HP:0001498) | 3.15206877 |
| 18 | Poor head control (HP:0002421) | 3.07461541 |
| 19 | Aplastic anemia (HP:0001915) | 3.04837894 |
| 20 | Macrocytic anemia (HP:0001972) | 3.01544725 |
| 21 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.00264013 |
| 22 | Increased CSF lactate (HP:0002490) | 2.99237296 |
| 23 | Trismus (HP:0000211) | 2.95602616 |
| 24 | Leukodystrophy (HP:0002415) | 2.94240893 |
| 25 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.93177035 |
| 26 | Increased serum lactate (HP:0002151) | 2.92374589 |
| 27 | Rough bone trabeculation (HP:0100670) | 2.88784188 |
| 28 | Birth length less than 3rd percentile (HP:0003561) | 2.78524006 |
| 29 | 3-Methylglutaconic aciduria (HP:0003535) | 2.78012747 |
| 30 | Microretrognathia (HP:0000308) | 2.76201317 |
| 31 | Pallor (HP:0000980) | 2.75579393 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.74524322 |
| 33 | Acute encephalopathy (HP:0006846) | 2.71647895 |
| 34 | Optic disc pallor (HP:0000543) | 2.66339434 |
| 35 | Breast hypoplasia (HP:0003187) | 2.64433680 |
| 36 | Type I transferrin isoform profile (HP:0003642) | 2.61843766 |
| 37 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.51050300 |
| 38 | Abnormality of renal resorption (HP:0011038) | 2.47873000 |
| 39 | Tongue fasciculations (HP:0001308) | 2.43569454 |
| 40 | Nausea (HP:0002018) | 2.43089682 |
| 41 | Progressive muscle weakness (HP:0003323) | 2.42454717 |
| 42 | Patellar aplasia (HP:0006443) | 2.41838227 |
| 43 | Exertional dyspnea (HP:0002875) | 2.39254203 |
| 44 | Abnormal hemoglobin (HP:0011902) | 2.37343098 |
| 45 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.36281233 |
| 46 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.34709764 |
| 47 | Premature ovarian failure (HP:0008209) | 2.34315469 |
| 48 | Respiratory failure (HP:0002878) | 2.32877452 |
| 49 | Secondary amenorrhea (HP:0000869) | 2.29919369 |
| 50 | Lactic acidosis (HP:0003128) | 2.29310920 |
| 51 | Microvesicular hepatic steatosis (HP:0001414) | 2.27386069 |
| 52 | Exercise intolerance (HP:0003546) | 2.25724461 |
| 53 | Chromsome breakage (HP:0040012) | 2.25028714 |
| 54 | Premature graying of hair (HP:0002216) | 2.24117318 |
| 55 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.22838367 |
| 56 | Progressive macrocephaly (HP:0004481) | 2.19385538 |
| 57 | Sparse eyelashes (HP:0000653) | 2.18892453 |
| 58 | CNS demyelination (HP:0007305) | 2.18634696 |
| 59 | Muscle fibrillation (HP:0010546) | 2.18359237 |
| 60 | Cerebral edema (HP:0002181) | 2.17335782 |
| 61 | Emotional lability (HP:0000712) | 2.16179640 |
| 62 | Absent thumb (HP:0009777) | 2.15973201 |
| 63 | X-linked dominant inheritance (HP:0001423) | 2.15420508 |
| 64 | Cleft eyelid (HP:0000625) | 2.12388276 |
| 65 | Abnormality of the ileum (HP:0001549) | 2.11235314 |
| 66 | Meckel diverticulum (HP:0002245) | 2.08807078 |
| 67 | Selective tooth agenesis (HP:0001592) | 2.08740591 |
| 68 | Testicular atrophy (HP:0000029) | 2.08245782 |
| 69 | Generalized aminoaciduria (HP:0002909) | 2.08047278 |
| 70 | Increased hepatocellular lipid droplets (HP:0006565) | 2.07129640 |
| 71 | Methylmalonic aciduria (HP:0012120) | 2.04862977 |
| 72 | Congenital, generalized hypertrichosis (HP:0004540) | 2.03236116 |
| 73 | Lethargy (HP:0001254) | 2.03107658 |
| 74 | Abnormal trabecular bone morphology (HP:0100671) | 2.02959941 |
| 75 | Vertebral compression fractures (HP:0002953) | 2.01007409 |
| 76 | Renal Fanconi syndrome (HP:0001994) | 1.99464458 |
| 77 | Abnormality of urine glucose concentration (HP:0011016) | 1.99389240 |
| 78 | Glycosuria (HP:0003076) | 1.99389240 |
| 79 | Lipid accumulation in hepatocytes (HP:0006561) | 1.98910739 |
| 80 | Reduced antithrombin III activity (HP:0001976) | 1.98592562 |
| 81 | Increased intramyocellular lipid droplets (HP:0012240) | 1.98532892 |
| 82 | Abnormality of the preputium (HP:0100587) | 1.98282936 |
| 83 | Hyperphosphaturia (HP:0003109) | 1.95477625 |
| 84 | Petechiae (HP:0000967) | 1.95477184 |
| 85 | Eczematoid dermatitis (HP:0000976) | 1.94854681 |
| 86 | Bone marrow hypocellularity (HP:0005528) | 1.92236985 |
| 87 | Increased serum pyruvate (HP:0003542) | 1.91731761 |
| 88 | Abnormality of glycolysis (HP:0004366) | 1.91731761 |
| 89 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.91383369 |
| 90 | Pancytopenia (HP:0001876) | 1.90994847 |
| 91 | Increased IgM level (HP:0003496) | 1.90632250 |
| 92 | Abnormality of methionine metabolism (HP:0010901) | 1.90618280 |
| 93 | Increased muscle lipid content (HP:0009058) | 1.88240065 |
| 94 | Hyperglycinemia (HP:0002154) | 1.85242395 |
| 95 | Triphalangeal thumb (HP:0001199) | 1.82647099 |
| 96 | Recurrent abscess formation (HP:0002722) | 1.82299744 |
| 97 | Methylmalonic acidemia (HP:0002912) | 1.81200697 |
| 98 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.81064538 |
| 99 | Thrombocytosis (HP:0001894) | 1.80280955 |
| 100 | Abnormality of alanine metabolism (HP:0010916) | 1.79762476 |
| 101 | Hyperalaninemia (HP:0003348) | 1.79762476 |
| 102 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.79762476 |
| 103 | Colon cancer (HP:0003003) | 1.79715498 |
| 104 | Dicarboxylic aciduria (HP:0003215) | 1.79387681 |
| 105 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.79387681 |
| 106 | Horseshoe kidney (HP:0000085) | 1.79216236 |
| 107 | Muscle fiber atrophy (HP:0100295) | 1.77788813 |
| 108 | Ragged-red muscle fibers (HP:0003200) | 1.74970504 |
| 109 | Agnosia (HP:0010524) | 1.74399683 |
| 110 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.74369631 |
| 111 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.72887257 |
| 112 | IgM deficiency (HP:0002850) | 1.72389886 |
| 113 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.72247212 |
| 114 | Blindness (HP:0000618) | 1.72158766 |
| 115 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.70809375 |
| 116 | Personality changes (HP:0000751) | 1.69055742 |
| 117 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.68193008 |
| 118 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.68193008 |
| 119 | Abnormal protein glycosylation (HP:0012346) | 1.68193008 |
| 120 | Abnormal glycosylation (HP:0012345) | 1.68193008 |
| 121 | Abnormality of reticulocytes (HP:0004312) | 1.67978625 |
| 122 | Recurrent bacterial skin infections (HP:0005406) | 1.67646995 |
| 123 | Tracheoesophageal fistula (HP:0002575) | 1.67471726 |
| 124 | Angiofibromas (HP:0010615) | 1.66828989 |
| 125 | Adenoma sebaceum (HP:0009720) | 1.66828989 |
| 126 | Abnormality of the motor neurons (HP:0002450) | 1.66036539 |
| 127 | Abnormal neuron morphology (HP:0012757) | 1.66036539 |
| 128 | Vacuolated lymphocytes (HP:0001922) | 1.65911274 |
| 129 | Abnormality of placental membranes (HP:0011409) | 1.58794208 |
| 130 | Amniotic constriction ring (HP:0009775) | 1.58794208 |
| 131 | Gliosis (HP:0002171) | 1.58772890 |
| 132 | Vomiting (HP:0002013) | 1.57227362 |
| 133 | Gout (HP:0001997) | 1.56592972 |
| 134 | Hypoplasia of the pons (HP:0012110) | 1.55569406 |
| 135 | Death in infancy (HP:0001522) | 1.55358603 |
| 136 | Megaloblastic anemia (HP:0001889) | 1.54757325 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.69974909 |
| 2 | BUB1 | 4.10078110 |
| 3 | TESK2 | 3.87798807 |
| 4 | NME2 | 3.75283239 |
| 5 | EIF2AK1 | 3.44071330 |
| 6 | PIM2 | 3.00982626 |
| 7 | TLK1 | 2.66217951 |
| 8 | TESK1 | 2.61765254 |
| 9 | WEE1 | 2.57759710 |
| 10 | ERN1 | 2.26949004 |
| 11 | IRAK3 | 2.24944268 |
| 12 | MAP3K11 | 2.19934521 |
| 13 | BCKDK | 2.17363397 |
| 14 | STK16 | 2.09313396 |
| 15 | EIF2AK3 | 1.94996118 |
| 16 | PLK4 | 1.87102197 |
| 17 | SRPK1 | 1.84092700 |
| 18 | PDK2 | 1.77379524 |
| 19 | NEK1 | 1.76927111 |
| 20 | TSSK6 | 1.67672123 |
| 21 | VRK1 | 1.57895813 |
| 22 | LIMK1 | 1.49209634 |
| 23 | KDR | 1.41732434 |
| 24 | CDK7 | 1.39805849 |
| 25 | IRAK4 | 1.33768091 |
| 26 | PLK1 | 1.33128622 |
| 27 | PAK4 | 1.33003391 |
| 28 | NME1 | 1.30899297 |
| 29 | EPHA2 | 1.30243846 |
| 30 | BRAF | 1.28042177 |
| 31 | NUAK1 | 1.26704408 |
| 32 | TAF1 | 1.26002113 |
| 33 | BLK | 1.22066264 |
| 34 | AURKA | 1.13042333 |
| 35 | ARAF | 1.12935980 |
| 36 | CDC7 | 1.11391345 |
| 37 | RPS6KA4 | 1.09398414 |
| 38 | ABL2 | 1.09312659 |
| 39 | CCNB1 | 1.08676043 |
| 40 | PIM1 | 1.08499573 |
| 41 | MAP4K1 | 1.07657172 |
| 42 | TAOK2 | 1.06462989 |
| 43 | TTK | 1.04746065 |
| 44 | ACVR1B | 1.04065442 |
| 45 | BRSK2 | 1.01175085 |
| 46 | RPS6KB2 | 0.98124164 |
| 47 | PBK | 0.94295933 |
| 48 | DYRK3 | 0.94258455 |
| 49 | DAPK3 | 0.93545050 |
| 50 | ILK | 0.89121351 |
| 51 | AURKB | 0.86994238 |
| 52 | ZAP70 | 0.86605537 |
| 53 | BRSK1 | 0.86578797 |
| 54 | LRRK2 | 0.85784371 |
| 55 | MATK | 0.85306018 |
| 56 | CDK12 | 0.85191823 |
| 57 | ZAK | 0.84621577 |
| 58 | DAPK1 | 0.83015669 |
| 59 | NEK2 | 0.82259151 |
| 60 | MAP3K8 | 0.82219160 |
| 61 | GRK6 | 0.82121399 |
| 62 | TRIM28 | 0.80584651 |
| 63 | GRK5 | 0.80081941 |
| 64 | PAK1 | 0.78288779 |
| 65 | MAPKAPK3 | 0.77162672 |
| 66 | MAP3K12 | 0.75933286 |
| 67 | PRKCI | 0.75612433 |
| 68 | CLK1 | 0.75160807 |
| 69 | IKBKB | 0.74641466 |
| 70 | ATR | 0.73198887 |
| 71 | STK10 | 0.72608827 |
| 72 | CHEK1 | 0.72312538 |
| 73 | CSNK2A1 | 0.70223007 |
| 74 | TBK1 | 0.67406160 |
| 75 | RPS6KA5 | 0.66235942 |
| 76 | AKT3 | 0.64753926 |
| 77 | CSNK1G3 | 0.62109562 |
| 78 | SCYL2 | 0.62065344 |
| 79 | CDK8 | 0.61796367 |
| 80 | MAP4K2 | 0.59662391 |
| 81 | MKNK2 | 0.59650292 |
| 82 | NEK9 | 0.56801835 |
| 83 | SIK3 | 0.55648152 |
| 84 | MYLK | 0.55489515 |
| 85 | CSNK2A2 | 0.54862069 |
| 86 | TXK | 0.54674026 |
| 87 | CDK4 | 0.53321618 |
| 88 | MAP3K10 | 0.52606486 |
| 89 | LATS2 | 0.52539929 |
| 90 | TRIB3 | 0.51896653 |
| 91 | PLK3 | 0.51795692 |
| 92 | CHEK2 | 0.51008414 |
| 93 | RPS6KA6 | 0.50952332 |
| 94 | MAP2K2 | 0.50328619 |
| 95 | BTK | 0.50309113 |
| 96 | MST4 | 0.50211297 |
| 97 | STK4 | 0.50207005 |
| 98 | RPS6KC1 | 0.49417512 |
| 99 | RPS6KL1 | 0.49417512 |
| 100 | EIF2AK2 | 0.49395294 |
| 101 | ATM | 0.49267574 |
| 102 | IRAK1 | 0.48121995 |
| 103 | TYK2 | 0.47925022 |
| 104 | MKNK1 | 0.47873719 |
| 105 | FLT3 | 0.47597485 |
| 106 | CSNK1E | 0.47567007 |
| 107 | CSNK1G1 | 0.46758181 |
| 108 | DYRK2 | 0.46709853 |
| 109 | CDK19 | 0.45537530 |
| 110 | PASK | 0.45358958 |
| 111 | BMX | 0.44505576 |
| 112 | ADRBK2 | 0.44379055 |
| 113 | ALK | 0.44038114 |
| 114 | INSRR | 0.42289992 |
| 115 | CDK1 | 0.40647256 |
| 116 | MAP3K3 | 0.40339521 |
| 117 | CDK2 | 0.39297797 |
| 118 | PRKCD | 0.38796930 |
| 119 | MAPKAPK5 | 0.38708510 |
| 120 | CDK11A | 0.35658180 |
| 121 | CDK14 | 0.33508551 |
| 122 | CSNK1G2 | 0.31243004 |
| 123 | CSNK1A1L | 0.28956491 |
| 124 | AKT2 | 0.28123347 |
| 125 | WNK3 | 0.27820326 |
| 126 | CDK15 | 0.27656920 |
| 127 | CDK18 | 0.26165427 |
| 128 | CSNK1A1 | 0.25474085 |
| 129 | ERBB4 | 0.25064686 |
| 130 | WNK4 | 0.23138411 |
| 131 | MAP2K7 | 0.19781668 |
| 132 | MARK3 | 0.16386942 |
| 133 | CDK3 | 0.16374133 |
| 134 | PRKDC | 0.15077503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.52929159 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.16380680 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.82486003 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.41517465 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.25394063 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.78016016 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.63828786 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.55972032 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.53214032 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.24029946 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.23016952 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.21044465 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.13269506 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.09224060 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 2.04198441 |
| 16 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.80962731 |
| 17 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.75037483 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.63135050 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.61516886 |
| 20 | Sulfur relay system_Homo sapiens_hsa04122 | 1.59978958 |
| 21 | Protein export_Homo sapiens_hsa03060 | 1.58766182 |
| 22 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.46288218 |
| 23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.41592793 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.36383776 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.32753677 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.27268200 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.26633766 |
| 28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.23433235 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.18917306 |
| 30 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.16290392 |
| 31 | RNA degradation_Homo sapiens_hsa03018 | 1.16207641 |
| 32 | Basal transcription factors_Homo sapiens_hsa03022 | 1.15835112 |
| 33 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.12696458 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.12640203 |
| 35 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.12578549 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.09816372 |
| 37 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.09498859 |
| 38 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.08754731 |
| 39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08585262 |
| 40 | Alzheimers disease_Homo sapiens_hsa05010 | 1.07973912 |
| 41 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.01700141 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.01573900 |
| 43 | Legionellosis_Homo sapiens_hsa05134 | 1.01543250 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 1.00633030 |
| 45 | Galactose metabolism_Homo sapiens_hsa00052 | 0.97048840 |
| 46 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.95619147 |
| 47 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.94748431 |
| 48 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.93580675 |
| 49 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.87444933 |
| 50 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.84621421 |
| 51 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.83526437 |
| 52 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.82274780 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80641833 |
| 54 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.71543865 |
| 55 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.70368286 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.70053192 |
| 57 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.69979814 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.69542052 |
| 59 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.69095694 |
| 60 | Other glycan degradation_Homo sapiens_hsa00511 | 0.68825005 |
| 61 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.64589608 |
| 62 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.62060329 |
| 63 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.62005185 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61102437 |
| 65 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.59791869 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58093126 |
| 67 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.57456337 |
| 68 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51924184 |
| 69 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50085740 |
| 70 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.48184938 |
| 71 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.47549979 |
| 72 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47145962 |
| 73 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.45745564 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43859722 |
| 75 | Leishmaniasis_Homo sapiens_hsa05140 | 0.43543949 |
| 76 | Shigellosis_Homo sapiens_hsa05131 | 0.43430657 |
| 77 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.43131713 |
| 78 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.41638398 |
| 79 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40915543 |
| 80 | Apoptosis_Homo sapiens_hsa04210 | 0.40486548 |
| 81 | Asthma_Homo sapiens_hsa05310 | 0.37160063 |
| 82 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.36164133 |
| 83 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.35857283 |
| 84 | Thyroid cancer_Homo sapiens_hsa05216 | 0.35775772 |
| 85 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.35040645 |
| 86 | Peroxisome_Homo sapiens_hsa04146 | 0.34037865 |
| 87 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33109908 |
| 88 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.32328233 |
| 89 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31451532 |
| 90 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.31172635 |
| 91 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30871164 |
| 92 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.30744524 |
| 93 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.30316806 |
| 94 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.30119044 |
| 95 | Measles_Homo sapiens_hsa05162 | 0.29863831 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29607227 |
| 97 | Allograft rejection_Homo sapiens_hsa05330 | 0.28734718 |
| 98 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.28475327 |
| 99 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.28178918 |
| 100 | Bladder cancer_Homo sapiens_hsa05219 | 0.28036778 |
| 101 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.26992602 |
| 102 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.26629269 |
| 103 | Lysosome_Homo sapiens_hsa04142 | 0.26502324 |
| 104 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.26348143 |
| 105 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.25532357 |
| 106 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.25241570 |
| 107 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.24974536 |
| 108 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.22752878 |
| 109 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.22721462 |
| 110 | HTLV-I infection_Homo sapiens_hsa05166 | 0.22493750 |
| 111 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.21587313 |
| 112 | Pertussis_Homo sapiens_hsa05133 | 0.21039307 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.20112101 |
| 114 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.17210231 |
| 115 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.15040294 |
| 116 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.12417121 |
| 117 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.11720405 |
| 118 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.09591750 |
| 119 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.08519539 |
| 120 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.07499148 |
| 121 | Retinol metabolism_Homo sapiens_hsa00830 | 0.05293027 |
| 122 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.03793224 |
| 123 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.03100831 |

