TOMM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.65060133
2ribosomal small subunit biogenesis (GO:0042274)8.46665147
3translational termination (GO:0006415)8.29441810
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.87704384
5ribosomal small subunit assembly (GO:0000028)7.60211911
6ATP synthesis coupled proton transport (GO:0015986)7.49891851
7energy coupled proton transport, down electrochemical gradient (GO:0015985)7.49891851
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.37840635
9cotranslational protein targeting to membrane (GO:0006613)7.36508857
10protein targeting to ER (GO:0045047)7.29629437
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.96728010
12translational elongation (GO:0006414)6.91992368
13protein localization to endoplasmic reticulum (GO:0070972)6.89747758
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.82099124
15viral life cycle (GO:0019058)6.52121503
16cellular protein complex disassembly (GO:0043624)6.51083814
17maturation of SSU-rRNA (GO:0030490)6.20871750
18ribosomal large subunit biogenesis (GO:0042273)6.18468340
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.08773295
20respiratory electron transport chain (GO:0022904)6.06758485
21translational initiation (GO:0006413)5.93690864
22electron transport chain (GO:0022900)5.93138372
23GTP biosynthetic process (GO:0006183)5.78441899
24protein complex disassembly (GO:0043241)5.46504331
25macromolecular complex disassembly (GO:0032984)5.16907033
26translation (GO:0006412)5.10682381
27UTP biosynthetic process (GO:0006228)5.07995763
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.98640924
29protein targeting to membrane (GO:0006612)4.80496575
30protein neddylation (GO:0045116)4.57710528
31UTP metabolic process (GO:0046051)4.42866088
32guanosine-containing compound biosynthetic process (GO:1901070)4.38374299
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.36950966
34termination of RNA polymerase III transcription (GO:0006386)4.36950966
35proteasome assembly (GO:0043248)4.35722957
36chaperone-mediated protein transport (GO:0072321)4.35455760
37ribonucleoprotein complex biogenesis (GO:0022613)4.28497171
38mitochondrial respiratory chain complex I assembly (GO:0032981)4.26916172
39NADH dehydrogenase complex assembly (GO:0010257)4.26916172
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.26916172
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.23586503
42nuclear-transcribed mRNA catabolic process (GO:0000956)4.23272625
43protein complex biogenesis (GO:0070271)4.20477061
44DNA deamination (GO:0045006)4.16893323
45CTP biosynthetic process (GO:0006241)4.14188308
46CTP metabolic process (GO:0046036)4.14188308
47purine nucleoside triphosphate biosynthetic process (GO:0009145)4.12248396
48mRNA catabolic process (GO:0006402)4.00067335
49cellular component biogenesis (GO:0044085)3.92482690
50mitochondrial respiratory chain complex assembly (GO:0033108)3.92332268
51ATP biosynthetic process (GO:0006754)3.79342105
52ribonucleoside triphosphate biosynthetic process (GO:0009201)3.77582888
53regulation of mitochondrial translation (GO:0070129)3.77169129
54pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.73478047
55nucleoside diphosphate phosphorylation (GO:0006165)3.66875142
56pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.66272244
57hydrogen ion transmembrane transport (GO:1902600)3.65771591
58RNA catabolic process (GO:0006401)3.63657064
59rRNA processing (GO:0006364)3.61176209
60protein localization to membrane (GO:0072657)3.51491677
61establishment of integrated proviral latency (GO:0075713)3.48313494
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.47389115
63formation of translation preinitiation complex (GO:0001731)3.46210598
64rRNA metabolic process (GO:0016072)3.45973870
65purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.45498169
66purine nucleoside monophosphate biosynthetic process (GO:0009127)3.45498169
67establishment of protein localization to membrane (GO:0090150)3.44067272
687-methylguanosine mRNA capping (GO:0006370)3.43043471
69* mitochondrial transport (GO:0006839)3.42494558
70spliceosomal complex assembly (GO:0000245)3.42355100
717-methylguanosine RNA capping (GO:0009452)3.37148406
72RNA capping (GO:0036260)3.37148406
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35374841
74spliceosomal snRNP assembly (GO:0000387)3.34118999
75pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.33038148
76* protein targeting (GO:0006605)3.32705223
77cytochrome complex assembly (GO:0017004)3.32216044
78* establishment of protein localization to mitochondrion (GO:0072655)3.29596272
79* protein targeting to mitochondrion (GO:0006626)3.28668677
80nucleoside triphosphate biosynthetic process (GO:0009142)3.28667117
81aerobic respiration (GO:0009060)3.28166960
82inner mitochondrial membrane organization (GO:0007007)3.25162756
83regulation of cellular amino acid metabolic process (GO:0006521)3.23280447
84proton transport (GO:0015992)3.21261837
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14815753
86oxidative phosphorylation (GO:0006119)3.12781635
87transcription elongation from RNA polymerase I promoter (GO:0006362)3.12740009
88establishment of viral latency (GO:0019043)3.12618487
89rRNA modification (GO:0000154)3.12265047
90hydrogen transport (GO:0006818)3.12186023
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11852528
92respiratory chain complex IV assembly (GO:0008535)3.11120126
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11031730
94negative regulation of ligase activity (GO:0051352)3.11031730
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10618691
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09120704
97* establishment of protein localization to organelle (GO:0072594)3.06872445
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06542475
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04979221
100ribonucleoside monophosphate biosynthetic process (GO:0009156)3.03094419
101* protein localization to mitochondrion (GO:0070585)3.02726545
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00782812
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00782812
104termination of RNA polymerase I transcription (GO:0006363)3.00165106
105DNA damage response, detection of DNA damage (GO:0042769)2.98476827
106nucleoside monophosphate biosynthetic process (GO:0009124)2.98259580
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97758022
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97470451
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97470451
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97470451
111peptidyl-histidine modification (GO:0018202)2.94172775
112transcription from RNA polymerase I promoter (GO:0006360)2.93175252
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88634002
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86460441
115pseudouridine synthesis (GO:0001522)2.84264518
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83537696
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83537696
118water-soluble vitamin biosynthetic process (GO:0042364)2.78564079
119* intracellular protein transmembrane import (GO:0044743)2.76634366
120protein-cofactor linkage (GO:0018065)2.74828490
121* protein localization to organelle (GO:0033365)2.72679220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.18838564
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71151026
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.59021619
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.42206142
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.32155635
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.15870793
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73208337
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.69244955
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64098868
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42569136
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23609005
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20771475
13* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.20391935
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05071280
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90865911
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89484221
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84762280
18VDR_23849224_ChIP-Seq_CD4+_Human2.58390221
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51706122
20XRN2_22483619_ChIP-Seq_HELA_Human2.43038775
21DCP1A_22483619_ChIP-Seq_HELA_Human2.39257550
22ELK1_19687146_ChIP-ChIP_HELA_Human2.35987252
23TTF2_22483619_ChIP-Seq_HELA_Human2.28189016
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24098099
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12857008
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12734779
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.06909779
28* SRF_21415370_ChIP-Seq_HL-1_Mouse2.00343904
29* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.99104212
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.98524238
31FOXP3_21729870_ChIP-Seq_TREG_Human1.95887526
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91024401
33E2F7_22180533_ChIP-Seq_HELA_Human1.89082298
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84387453
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.84245107
36* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81122313
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67955473
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67831624
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67580610
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59353974
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55518680
42MYC_18940864_ChIP-ChIP_HL60_Human1.51937972
43* GABP_19822575_ChIP-Seq_HepG2_Human1.49016236
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48699212
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46580739
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45201677
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.44609530
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44256335
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44005781
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43719631
51IRF1_19129219_ChIP-ChIP_H3396_Human1.42016093
52* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40031969
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36840589
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34903407
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34348002
56ZNF263_19887448_ChIP-Seq_K562_Human1.32852396
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30631216
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27750324
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22669764
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22444199
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18354821
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17329923
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15859216
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14899006
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09828859
66VDR_22108803_ChIP-Seq_LS180_Human1.09637508
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03785264
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00628494
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00233817
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99975035
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97740757
72SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95956577
73CTCF_26484167_Chip-Seq_Bcells_Mouse0.95569794
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95273288
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94203392
76FOXP1_21924763_ChIP-Seq_HESCs_Human0.94097844
77STAT1_20625510_ChIP-Seq_HELA_Human0.89558353
78* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89498859
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88864035
80TET1_21451524_ChIP-Seq_MESCs_Mouse0.87867797
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.87789266
82KDM5A_27292631_Chip-Seq_BREAST_Human0.86513515
83* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85977013
84SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85240735
85FUS_26573619_Chip-Seq_HEK293_Human0.85084802
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81408976
87* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80697876
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79467704
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79159445
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79141408
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78938832
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78814174
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77905715
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.76827836
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75341598
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74827266
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74734697
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.73688742
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73068739
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73068739
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73068739
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73052019
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.72681232
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72597731
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71781548
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.70224300
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.69552745
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68534713
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68260235
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67388931
111SA1_27219007_Chip-Seq_Bcells_Human0.67126219
112NANOG_18692474_ChIP-Seq_MEFs_Mouse0.66389000
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66211477
114* CTCF_20526341_ChIP-Seq_ESCs_Human0.66101497
115ELF5_23300383_ChIP-Seq_T47D_Human0.65792998
116* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65733983
117ERG_20517297_ChIP-Seq_VCAP_Human0.65550577
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65302667
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65011118
120CBX2_27304074_Chip-Seq_ESCs_Mouse0.65004941
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.63224076
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.62394211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.95926396
2MP0003136_yellow_coat_color4.77371193
3MP0001529_abnormal_vocalization3.11485148
4MP0003693_abnormal_embryo_hatching2.63162594
5MP0010030_abnormal_orbit_morphology2.62108343
6MP0001905_abnormal_dopamine_level2.51918719
7MP0004381_abnormal_hair_follicle2.44179509
8MP0006292_abnormal_olfactory_placode2.42188764
9MP0002638_abnormal_pupillary_reflex2.39548207
10MP0004957_abnormal_blastocyst_morpholog2.25835131
11MP0002163_abnormal_gland_morphology2.21695167
12MP0003186_abnormal_redox_activity2.12176968
13MP0002277_abnormal_respiratory_mucosa2.11079504
14MP0003880_abnormal_central_pattern2.09181419
15MP0008932_abnormal_embryonic_tissue2.06118480
16MP0005379_endocrine/exocrine_gland_phen2.04574003
17MP0001188_hyperpigmentation2.01895045
18MP0005503_abnormal_tendon_morphology1.96646707
19MP0002102_abnormal_ear_morphology1.95574961
20MP0003315_abnormal_perineum_morphology1.95309740
21MP0002132_abnormal_respiratory_system1.88488740
22MP0006036_abnormal_mitochondrial_physio1.83921175
23MP0008057_abnormal_DNA_replication1.82978876
24MP0003718_maternal_effect1.82337068
25MP0006276_abnormal_autonomic_nervous1.77514412
26MP0003646_muscle_fatigue1.70249531
27MP0005409_darkened_coat_color1.67921034
28MP0004142_abnormal_muscle_tone1.66978684
29MP0004145_abnormal_muscle_electrophysio1.63930005
30MP0002938_white_spotting1.63727794
31MP0003786_premature_aging1.59796030
32MP0001986_abnormal_taste_sensitivity1.56489006
33MP0003938_abnormal_ear_development1.53612817
34MP0000372_irregular_coat_pigmentation1.53247359
35MP0006072_abnormal_retinal_apoptosis1.53161643
36MP0003011_delayed_dark_adaptation1.49228396
37MP0006035_abnormal_mitochondrial_morpho1.47795591
38MP0000750_abnormal_muscle_regeneration1.43134515
39MP0001485_abnormal_pinna_reflex1.42692587
40MP0005410_abnormal_fertilization1.41858469
41MP0008789_abnormal_olfactory_epithelium1.39581930
42MP0002148_abnormal_hypersensitivity_rea1.39189672
43MP0000049_abnormal_middle_ear1.34655365
44MP0003283_abnormal_digestive_organ1.33170439
45MP0002736_abnormal_nociception_after1.30643444
46MP0001727_abnormal_embryo_implantation1.28988801
47MP0003724_increased_susceptibility_to1.27404705
48MP0005408_hypopigmentation1.21939331
49MP0005075_abnormal_melanosome_morpholog1.20771548
50MP0003077_abnormal_cell_cycle1.20213123
51MP0003567_abnormal_fetal_cardiomyocyte1.20110031
52MP0000566_synostosis1.19443147
53MP0008995_early_reproductive_senescence1.18516950
54MP0008058_abnormal_DNA_repair1.16866154
55MP0010094_abnormal_chromosome_stability1.13944980
56MP0001293_anophthalmia1.13872818
57MP0001968_abnormal_touch/_nociception1.10045438
58MP0002234_abnormal_pharynx_morphology1.09949391
59MP0005174_abnormal_tail_pigmentation1.09745425
60MP0002751_abnormal_autonomic_nervous1.08671043
61MP0004885_abnormal_endolymph1.07982785
62MP0003941_abnormal_skin_development1.06704312
63MP0000026_abnormal_inner_ear1.06680711
64MP0004133_heterotaxia1.05442033
65MP0004742_abnormal_vestibular_system1.05375309
66MP0004019_abnormal_vitamin_homeostasis1.04364782
67MP0002095_abnormal_skin_pigmentation1.02502711
68MP0001440_abnormal_grooming_behavior1.00113117
69MP0001984_abnormal_olfaction0.99442586
70MP0005332_abnormal_amino_acid0.99014044
71MP0008004_abnormal_stomach_pH0.98428842
72MP0000762_abnormal_tongue_morphology0.96484340
73MP0009785_altered_susceptibility_to0.94331092
74MP0000749_muscle_degeneration0.90675604
75MP0002160_abnormal_reproductive_system0.90532926
76MP0003111_abnormal_nucleus_morphology0.88680535
77MP0005636_abnormal_mineral_homeostasis0.87073809
78MP0001853_heart_inflammation0.86701823
79MP0008875_abnormal_xenobiotic_pharmacok0.86648932
80MP0005551_abnormal_eye_electrophysiolog0.86152713
81MP0002837_dystrophic_cardiac_calcinosis0.85380725
82MP0002282_abnormal_trachea_morphology0.85230554
83MP0005253_abnormal_eye_physiology0.84339889
84MP0005389_reproductive_system_phenotype0.83717916
85MP0009333_abnormal_splenocyte_physiolog0.82362484
86MP0009745_abnormal_behavioral_response0.82212085
87MP0005499_abnormal_olfactory_system0.81234979
88MP0005394_taste/olfaction_phenotype0.81234979
89MP0005171_absent_coat_pigmentation0.80579692
90MP0000613_abnormal_salivary_gland0.80397061
91MP0000490_abnormal_crypts_of0.80315687
92MP0001663_abnormal_digestive_system0.79591392
93MP0008872_abnormal_physiological_respon0.79496061
94MP0001919_abnormal_reproductive_system0.79443189
95MP0001346_abnormal_lacrimal_gland0.79121203
96MP0005377_hearing/vestibular/ear_phenot0.75888407
97MP0003878_abnormal_ear_physiology0.75888407
98MP0005381_digestive/alimentary_phenotyp0.75438307
99MP0000631_abnormal_neuroendocrine_gland0.73891740
100MP0002210_abnormal_sex_determination0.72823231
101MP0009250_abnormal_appendicular_skeleto0.72594336
102MP0002090_abnormal_vision0.72114254
103MP0002295_abnormal_pulmonary_circulatio0.72086096
104MP0001970_abnormal_pain_threshold0.71136797
105MP0005423_abnormal_somatic_nervous0.71085682
106MP0002653_abnormal_ependyma_morphology0.70104585
107MP0001881_abnormal_mammary_gland0.69131538
108MP0010386_abnormal_urinary_bladder0.68189847
109MP0001963_abnormal_hearing_physiology0.67776192
110MP0001929_abnormal_gametogenesis0.67589879
111MP0000015_abnormal_ear_pigmentation0.67439954
112MP0001542_abnormal_bone_strength0.66724156
113MP0002064_seizures0.66420864
114MP0003137_abnormal_impulse_conducting0.65643494
115MP0001764_abnormal_homeostasis0.65480553
116MP0003698_abnormal_male_reproductive0.63131146
117MP0002272_abnormal_nervous_system0.62417877
118MP0000678_abnormal_parathyroid_gland0.62321768
119MP0002752_abnormal_somatic_nervous0.62129905
120MP0000343_altered_response_to0.61363808
121MP0008007_abnormal_cellular_replicative0.60970533
122MP0005025_abnormal_response_to0.60482723
123MP0002249_abnormal_larynx_morphology0.60123084
124MP0003123_paternal_imprinting0.60034280
125MP0003806_abnormal_nucleotide_metabolis0.59648745
126MP0002796_impaired_skin_barrier0.58557749
127MP0009046_muscle_twitch0.56980294
128MP0002734_abnormal_mechanical_nocicepti0.56871038
129MP0002177_abnormal_outer_ear0.56705351
130MP0003638_abnormal_response/metabolism_0.56630689
131MP0005646_abnormal_pituitary_gland0.56518984

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.43047395
2Abnormality of cells of the erythroid lineage (HP:0012130)6.23125307
3Mitochondrial inheritance (HP:0001427)5.78913439
4Abnormal mitochondria in muscle tissue (HP:0008316)5.69041602
5Abnormal number of erythroid precursors (HP:0012131)5.54920371
6Progressive macrocephaly (HP:0004481)5.35802655
7Reticulocytopenia (HP:0001896)5.32475965
8Increased hepatocellular lipid droplets (HP:0006565)5.29879035
9Acute encephalopathy (HP:0006846)5.06151634
10Increased CSF lactate (HP:0002490)4.85985808
11Hepatocellular necrosis (HP:0001404)4.66138396
12Lipid accumulation in hepatocytes (HP:0006561)4.63340330
13Macrocytic anemia (HP:0001972)4.62783013
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.41145630
15Renal Fanconi syndrome (HP:0001994)4.38379455
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.08343457
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.08343457
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.07774187
19Hepatic necrosis (HP:0002605)4.02232601
203-Methylglutaconic aciduria (HP:0003535)3.98500721
21Pallor (HP:0000980)3.98448459
22Exertional dyspnea (HP:0002875)3.80611254
23Increased intramyocellular lipid droplets (HP:0012240)3.69025725
24Exercise intolerance (HP:0003546)3.58923337
25Cerebral edema (HP:0002181)3.49804713
26Abnormal ciliary motility (HP:0012262)3.48226235
27Optic disc pallor (HP:0000543)3.45518981
28Respiratory failure (HP:0002878)3.34382305
29Abnormal respiratory epithelium morphology (HP:0012253)3.25743207
30Abnormal respiratory motile cilium morphology (HP:0005938)3.25743207
31Abnormal respiratory motile cilium physiology (HP:0012261)3.23074531
32Increased serum lactate (HP:0002151)3.17933145
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15638718
34Leukodystrophy (HP:0002415)3.06752037
35Increased muscle lipid content (HP:0009058)3.06049708
36Abnormality of renal resorption (HP:0011038)3.05996196
37Lactic acidosis (HP:0003128)3.04704300
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01192161
39Respiratory difficulties (HP:0002880)3.00714701
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99200053
41Abnormal hemoglobin (HP:0011902)2.88671677
42Rhinitis (HP:0012384)2.72826708
43Parakeratosis (HP:0001036)2.63781049
44Abnormality of glycolysis (HP:0004366)2.51846663
45Increased serum pyruvate (HP:0003542)2.51846663
46Septo-optic dysplasia (HP:0100842)2.50299914
47Congenital, generalized hypertrichosis (HP:0004540)2.48880750
48Absent/shortened dynein arms (HP:0200106)2.44025001
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.44025001
50Abnormality of secondary sexual hair (HP:0009888)2.38280187
51Abnormality of the axillary hair (HP:0100134)2.38280187
52Hyperphosphaturia (HP:0003109)2.34989734
53Myokymia (HP:0002411)2.33316096
54Methylmalonic aciduria (HP:0012120)2.29680920
55Methylmalonic acidemia (HP:0002912)2.28861898
56Generalized aminoaciduria (HP:0002909)2.28079837
57Aplasia/hypoplasia of the uterus (HP:0008684)2.25660342
58Concave nail (HP:0001598)2.18161403
59Microvesicular hepatic steatosis (HP:0001414)2.17779894
60Congenital ichthyosiform erythroderma (HP:0007431)2.08168156
61Abnormality of urine glucose concentration (HP:0011016)2.07079949
62Glycosuria (HP:0003076)2.07079949
63CNS demyelination (HP:0007305)2.05465890
64Amniotic constriction ring (HP:0009775)2.04571885
65Abnormality of placental membranes (HP:0011409)2.04571885
66Aplastic anemia (HP:0001915)2.01867429
67Maternal diabetes (HP:0009800)2.00278994
68Stenosis of the external auditory canal (HP:0000402)1.99631929
69Colon cancer (HP:0003003)1.98354613
70Pancreatic cysts (HP:0001737)1.94886269
71True hermaphroditism (HP:0010459)1.93163074
72Oral leukoplakia (HP:0002745)1.92904202
73Type I transferrin isoform profile (HP:0003642)1.92289262
74Abnormal urine phosphate concentration (HP:0012599)1.91481332
75Breast hypoplasia (HP:0003187)1.90252827
76Emotional lability (HP:0000712)1.88415659
7711 pairs of ribs (HP:0000878)1.87439293
78X-linked dominant inheritance (HP:0001423)1.86264337
79Dicarboxylic aciduria (HP:0003215)1.86040638
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86040638
81Pancreatic fibrosis (HP:0100732)1.85812259
82Medial flaring of the eyebrow (HP:0010747)1.85469774
83Depressed nasal ridge (HP:0000457)1.85363072
84Cerebral hypomyelination (HP:0006808)1.84401360
85Hyperglycinemia (HP:0002154)1.82937562
86Renal tubular dysfunction (HP:0000124)1.81040026
87Pancytopenia (HP:0001876)1.80227843
88Megaloblastic anemia (HP:0001889)1.79507624
89Partial duplication of the phalanx of hand (HP:0009999)1.77617859
90Lethargy (HP:0001254)1.77561178
91Hypothermia (HP:0002045)1.77302386
92Asplenia (HP:0001746)1.75922223
93Triphalangeal thumb (HP:0001199)1.73806503
94Rough bone trabeculation (HP:0100670)1.70975879
95Sparse eyelashes (HP:0000653)1.70111894
96Neoplasm of head and neck (HP:0012288)1.69670913
97Esophageal neoplasm (HP:0100751)1.69670913
98Absent septum pellucidum (HP:0001331)1.69298544
99Nemaline bodies (HP:0003798)1.69013750
100Abnormal pupillary function (HP:0007686)1.68426104
101Reduced antithrombin III activity (HP:0001976)1.66311766
102Abnormality of serum amino acid levels (HP:0003112)1.65638881
103Testicular atrophy (HP:0000029)1.64870323
104Abnormality of methionine metabolism (HP:0010901)1.64115209
105Vomiting (HP:0002013)1.63602393
106Cleft eyelid (HP:0000625)1.63281461
107Muscle fiber inclusion bodies (HP:0100299)1.61298734
108Blindness (HP:0000618)1.60629308
109Chronic bronchitis (HP:0004469)1.59605774
110Sclerocornea (HP:0000647)1.58662691
111Secondary amenorrhea (HP:0000869)1.58402486
112Degeneration of anterior horn cells (HP:0002398)1.57860897
113Abnormality of the anterior horn cell (HP:0006802)1.57860897
114Sensory axonal neuropathy (HP:0003390)1.56825408
115Nasolacrimal duct obstruction (HP:0000579)1.56070863
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.55690815
117Fragile nails (HP:0001808)1.55258801
118Absent thumb (HP:0009777)1.54897344
119Poor suck (HP:0002033)1.54851095
120Bronchiectasis (HP:0002110)1.54135761
121Woolly hair (HP:0002224)1.53784742
122Hypoplasia of the uterus (HP:0000013)1.53546831
123Partial duplication of thumb phalanx (HP:0009944)1.51811066
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.51810085
125Trismus (HP:0000211)1.50823712
126Horseshoe kidney (HP:0000085)1.49283242
127Median cleft lip (HP:0000161)1.48411510
128Abnormality of reticulocytes (HP:0004312)1.47867026
129Hypoplasia of the radius (HP:0002984)1.47285057
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.47162405
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.44671661
132Gliosis (HP:0002171)1.42991115
133Myotonia (HP:0002486)1.42134724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.74772402
2NME24.64954243
3TLK14.26403995
4STK163.72789243
5MST43.00145662
6BUB12.91759226
7PBK2.87423813
8NME12.76209374
9VRK12.70421376
10WEE12.69308748
11SRPK12.40725227
12PASK2.02526301
13CDK192.00252838
14EIF2AK11.95159439
15PNCK1.91535562
16PDK21.88249503
17MAP3K121.76696289
18PIM21.75454516
19CASK1.67666171
20STK391.56667329
21GRK71.48462102
22ARAF1.43952482
23NEK11.42108157
24MYLK1.37031493
25TAF11.35811682
26PLK41.35373855
27PHKG21.35017198
28PHKG11.35017198
29TESK21.28145903
30IRAK31.28105211
31IRAK41.27118663
32MKNK21.26435047
33EIF2AK31.22805634
34ADRBK21.19975434
35MKNK11.19271761
36MAPK151.18970469
37OXSR11.08071430
38TNIK1.07664478
39LIMK11.05672954
40AURKA1.03339878
41BRAF1.02886271
42BCR1.02597124
43ABL21.01962779
44RPS6KB21.01456641
45MAPKAPK51.01367702
46BMPR1B1.00011870
47MUSK0.98189831
48DYRK20.96103129
49DYRK30.95849398
50GRK50.92707719
51BMPR20.91276852
52IRAK10.89961506
53RPS6KA50.86112698
54DAPK30.82011184
55AURKB0.80972761
56IRAK20.79758380
57ZAK0.78135793
58ILK0.78115215
59CSNK2A10.76578333
60CSNK2A20.74533414
61PINK10.74423578
62EIF2AK20.73706801
63PLK10.72943669
64CCNB10.72874510
65PRKCG0.72597031
66CSNK1G30.71740840
67ADRBK10.70950549
68BRSK20.69623678
69STK40.68329681
70WNK40.67665316
71TSSK60.67588171
72YES10.67246327
73TESK10.65351183
74INSRR0.64270338
75BRSK10.63589703
76CAMKK20.63542445
77GRK10.63423191
78LRRK20.61989938
79PLK30.59479956
80ACVR1B0.58902653
81FGR0.58819501
82BLK0.57825708
83KDR0.57569360
84MAPK120.57187659
85TEC0.57001413
86PAK10.54336581
87CAMK2B0.54269689
88MAP2K20.54138824
89UHMK10.52202677
90OBSCN0.51938382
91EPHA20.51115031
92NUAK10.49419704
93MAP4K20.48009281
94CDK70.44570313
95CSNK1G10.43450558
96PAK40.43012621
97CDK30.43005185
98TTK0.42969153
99CSNK1E0.42730392
100TXK0.42241320
101LYN0.41582318
102CAMK10.41187856
103CDC70.40249388
104PKN10.39335092
105MST1R0.38997003
106PIM10.38996135
107ROCK20.38729950
108CAMK2D0.38398215
109FES0.37606948
110PRKCI0.37439263
111BCKDK0.36255008
112TIE10.36238719
113IKBKB0.36197217
114MOS0.36064708
115PIK3CG0.35679780
116EPHB20.35502096
117CDK80.35485182
118MAPK130.34755039
119MAPK40.33352215
120CAMK2G0.33206615
121GRK60.33129876
122PRKACA0.33114491
123WNK30.32485755
124CSNK1G20.30933224
125MAPKAPK30.30417092
126CHEK20.29535182
127PRKG20.29369141
128STK240.28175696
129CSNK1A10.27568069
130TGFBR10.26153860
131PRKG10.25631092
132PRKCA0.24488626
133MAP2K60.24211937
134CAMK2A0.23864725

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.74769761
2Oxidative phosphorylation_Homo sapiens_hsa001905.41092207
3Parkinsons disease_Homo sapiens_hsa050124.61851837
4Proteasome_Homo sapiens_hsa030503.85668954
5Huntingtons disease_Homo sapiens_hsa050163.57764171
6RNA polymerase_Homo sapiens_hsa030203.45857187
7Alzheimers disease_Homo sapiens_hsa050103.44145074
8Protein export_Homo sapiens_hsa030603.01872313
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.96705411
10Pyrimidine metabolism_Homo sapiens_hsa002402.19526929
11DNA replication_Homo sapiens_hsa030302.18445205
12Spliceosome_Homo sapiens_hsa030402.11875069
13Cardiac muscle contraction_Homo sapiens_hsa042601.99787536
14Homologous recombination_Homo sapiens_hsa034401.95485035
15Mismatch repair_Homo sapiens_hsa034301.86721549
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73309748
17Nucleotide excision repair_Homo sapiens_hsa034201.71849983
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44448254
19Basal transcription factors_Homo sapiens_hsa030221.32361399
20Purine metabolism_Homo sapiens_hsa002301.22929593
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15305025
22RNA transport_Homo sapiens_hsa030131.12490764
23Fanconi anemia pathway_Homo sapiens_hsa034601.09485833
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08603810
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07231785
26Base excision repair_Homo sapiens_hsa034101.05657369
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98323666
28RNA degradation_Homo sapiens_hsa030180.98094080
29Collecting duct acid secretion_Homo sapiens_hsa049660.95726598
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95114661
31Glutathione metabolism_Homo sapiens_hsa004800.93394529
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90690930
33Non-homologous end-joining_Homo sapiens_hsa034500.84611989
34Arachidonic acid metabolism_Homo sapiens_hsa005900.84225694
35Fatty acid elongation_Homo sapiens_hsa000620.83988560
36Systemic lupus erythematosus_Homo sapiens_hsa053220.82653159
37Sulfur relay system_Homo sapiens_hsa041220.79546846
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78369382
39Sulfur metabolism_Homo sapiens_hsa009200.77666132
40Metabolic pathways_Homo sapiens_hsa011000.77418305
41Folate biosynthesis_Homo sapiens_hsa007900.76641707
42Ether lipid metabolism_Homo sapiens_hsa005650.66533887
43Graft-versus-host disease_Homo sapiens_hsa053320.65304552
44Linoleic acid metabolism_Homo sapiens_hsa005910.64614846
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62492059
46Vibrio cholerae infection_Homo sapiens_hsa051100.59678868
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58836251
48Vitamin digestion and absorption_Homo sapiens_hsa049770.57990724
49One carbon pool by folate_Homo sapiens_hsa006700.57599021
50Phototransduction_Homo sapiens_hsa047440.56306621
51Rheumatoid arthritis_Homo sapiens_hsa053230.53478674
52Autoimmune thyroid disease_Homo sapiens_hsa053200.52826274
53Epstein-Barr virus infection_Homo sapiens_hsa051690.50531392
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49197876
55Allograft rejection_Homo sapiens_hsa053300.48577887
56Tyrosine metabolism_Homo sapiens_hsa003500.48207567
57Sphingolipid metabolism_Homo sapiens_hsa006000.46882189
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46813009
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46699872
60Carbon metabolism_Homo sapiens_hsa012000.46684442
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46499588
62Asthma_Homo sapiens_hsa053100.46451650
63Cell cycle_Homo sapiens_hsa041100.45404086
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44089821
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43255259
66Nitrogen metabolism_Homo sapiens_hsa009100.42679828
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37161843
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36947774
69Alcoholism_Homo sapiens_hsa050340.36914138
70Pentose phosphate pathway_Homo sapiens_hsa000300.35114281
71Phenylalanine metabolism_Homo sapiens_hsa003600.34508992
72Mineral absorption_Homo sapiens_hsa049780.33402240
73Tryptophan metabolism_Homo sapiens_hsa003800.31878352
74Caffeine metabolism_Homo sapiens_hsa002320.29661845
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28794336
76Pyruvate metabolism_Homo sapiens_hsa006200.28271894
77beta-Alanine metabolism_Homo sapiens_hsa004100.28196845
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27471355
79Chemical carcinogenesis_Homo sapiens_hsa052040.27466731
80Fat digestion and absorption_Homo sapiens_hsa049750.27136653
81p53 signaling pathway_Homo sapiens_hsa041150.26359479
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25376322
83Selenocompound metabolism_Homo sapiens_hsa004500.24961441
84Arginine and proline metabolism_Homo sapiens_hsa003300.24906376
85Butanoate metabolism_Homo sapiens_hsa006500.24680765
86Basal cell carcinoma_Homo sapiens_hsa052170.24657102
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.24163475
88Biosynthesis of amino acids_Homo sapiens_hsa012300.23888580
89Serotonergic synapse_Homo sapiens_hsa047260.23732044
90Steroid biosynthesis_Homo sapiens_hsa001000.23396790
91Phagosome_Homo sapiens_hsa041450.22545683
92Histidine metabolism_Homo sapiens_hsa003400.22087027
93Fatty acid degradation_Homo sapiens_hsa000710.21678362
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21414989
95mRNA surveillance pathway_Homo sapiens_hsa030150.19542954
96Arginine biosynthesis_Homo sapiens_hsa002200.19036906
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18831962
98Hematopoietic cell lineage_Homo sapiens_hsa046400.18631573
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.18350708
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.18019448
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17713405
102Type I diabetes mellitus_Homo sapiens_hsa049400.17685636
103Vitamin B6 metabolism_Homo sapiens_hsa007500.17519839
104Other glycan degradation_Homo sapiens_hsa005110.16955082
105Nicotine addiction_Homo sapiens_hsa050330.16510954
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15588092
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15056285
108Regulation of autophagy_Homo sapiens_hsa041400.14553305
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.14501877
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14365750
111Retinol metabolism_Homo sapiens_hsa008300.13284248
112N-Glycan biosynthesis_Homo sapiens_hsa005100.10630681
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.10138011
114Primary immunodeficiency_Homo sapiens_hsa053400.10046005
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09743964
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08799756
117Galactose metabolism_Homo sapiens_hsa000520.08269362
118African trypanosomiasis_Homo sapiens_hsa051430.07141632
119Fructose and mannose metabolism_Homo sapiens_hsa000510.06339599
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06338805
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06326683
122Olfactory transduction_Homo sapiens_hsa047400.06200940
123Synaptic vesicle cycle_Homo sapiens_hsa047210.05773169
124Pertussis_Homo sapiens_hsa051330.05411873
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.04702351
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04590397
127Antigen processing and presentation_Homo sapiens_hsa046120.04587624
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.04407457
129Renin-angiotensin system_Homo sapiens_hsa046140.04166023
130Propanoate metabolism_Homo sapiens_hsa006400.04110788
131Peroxisome_Homo sapiens_hsa041460.03614254

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