TOMM70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)8.04555055
2embryonic camera-type eye morphogenesis (GO:0048596)5.97294975
3nuclear pore complex assembly (GO:0051292)5.85166433
4astrocyte differentiation (GO:0048708)5.70592110
5dorsal/ventral axis specification (GO:0009950)5.61139730
6negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)5.13445336
7nuclear pore organization (GO:0006999)5.12167581
8regulation of timing of cell differentiation (GO:0048505)5.08395373
9pre-miRNA processing (GO:0031054)4.95971819
10positive regulation of neuroblast proliferation (GO:0002052)4.76586922
11regulation of cell fate specification (GO:0042659)4.75445318
12gland morphogenesis (GO:0022612)4.73524176
13regulation of development, heterochronic (GO:0040034)4.72905187
14embryonic eye morphogenesis (GO:0048048)4.65412569
15receptor catabolic process (GO:0032801)4.64352683
16glandular epithelial cell development (GO:0002068)4.49180684
17positive regulation of cell fate commitment (GO:0010455)4.40534048
18regulation of RNA export from nucleus (GO:0046831)4.28853451
19embryonic foregut morphogenesis (GO:0048617)4.18848993
20mitotic chromosome condensation (GO:0007076)4.01501850
21regulation of translational fidelity (GO:0006450)3.99576478
22pore complex assembly (GO:0046931)3.98934535
23hindbrain development (GO:0030902)3.92339956
24DNA unwinding involved in DNA replication (GO:0006268)3.91696393
25protein retention in ER lumen (GO:0006621)3.87838316
26negative regulation of dendrite morphogenesis (GO:0050774)3.84250703
27gastrulation with mouth forming second (GO:0001702)3.82453231
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80925862
29columnar/cuboidal epithelial cell development (GO:0002066)3.67080230
30regulation of nucleobase-containing compound transport (GO:0032239)3.66168315
31positive regulation of DNA-templated transcription, initiation (GO:2000144)3.56319450
32regulation of NFAT protein import into nucleus (GO:0051532)3.48644680
33artery development (GO:0060840)3.43727041
34glucose catabolic process (GO:0006007)3.42269474
35regulation of neuroblast proliferation (GO:1902692)3.39691642
36mitotic sister chromatid cohesion (GO:0007064)3.36311107
37sister chromatid segregation (GO:0000819)3.33786509
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27974378
39mitotic sister chromatid segregation (GO:0000070)3.26403968
40glandular epithelial cell differentiation (GO:0002067)3.20376544
41protein localization to microtubule (GO:0035372)3.18247449
42mitotic nuclear envelope disassembly (GO:0007077)3.16016594
43DNA topological change (GO:0006265)3.14366272
44nuclear envelope disassembly (GO:0051081)3.06462557
45membrane disassembly (GO:0030397)3.06462557
46signal transduction involved in regulation of gene expression (GO:0023019)3.05414645
47regulation of anoikis (GO:2000209)3.04614601
48cellular protein complex localization (GO:0034629)3.02710389
49formation of translation preinitiation complex (GO:0001731)3.01231379
50mannose metabolic process (GO:0006013)2.97487755
51protein localization to chromosome, centromeric region (GO:0071459)2.97082073
52nucleobase-containing small molecule interconversion (GO:0015949)2.95036051
53regulation of transcription involved in cell fate commitment (GO:0060850)2.88960010
54regulation of sister chromatid cohesion (GO:0007063)2.88323908
55regulation of gene expression by genetic imprinting (GO:0006349)2.82851266
56regulation of mitotic spindle organization (GO:0060236)2.82284216
57COPI coating of Golgi vesicle (GO:0048205)2.82168528
58Golgi transport vesicle coating (GO:0048200)2.82168528
59protein complex localization (GO:0031503)2.81776618
60glutamine metabolic process (GO:0006541)2.81126644
61intestinal epithelial cell development (GO:0060576)2.79486467
62NLS-bearing protein import into nucleus (GO:0006607)2.78523006
63mammary gland epithelial cell proliferation (GO:0033598)2.77426073
64COPII vesicle coating (GO:0048208)2.76462570
65dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74766531
66ribosome assembly (GO:0042255)2.74218828
67trophectodermal cell differentiation (GO:0001829)2.73915946
68regulation of histone H3-K27 methylation (GO:0061085)2.71136628
69heparan sulfate proteoglycan metabolic process (GO:0030201)2.68951477
70lens development in camera-type eye (GO:0002088)2.67021999
71TOR signaling (GO:0031929)2.65032135
72mitotic metaphase plate congression (GO:0007080)2.62470370
73cellular response to virus (GO:0098586)2.61111377
74regulation of DNA-templated transcription, initiation (GO:2000142)2.60581898
75mRNA stabilization (GO:0048255)2.59643814
76RNA stabilization (GO:0043489)2.59643814
77paraxial mesoderm development (GO:0048339)2.55231739
78nuclear envelope organization (GO:0006998)2.53648576
79protein export from nucleus (GO:0006611)2.53547604
80positive regulation of neural precursor cell proliferation (GO:2000179)2.53090370
81pituitary gland development (GO:0021983)2.52827338
82mitochondrial fusion (GO:0008053)2.52634597
83regulation of chromosome segregation (GO:0051983)2.50447121
84protein localization to kinetochore (GO:0034501)2.50082804
85nucleotide-sugar biosynthetic process (GO:0009226)2.49723146
86regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48813158
87establishment of integrated proviral latency (GO:0075713)2.47808053
88DNA duplex unwinding (GO:0032508)2.47595916
89positive regulation of chromosome segregation (GO:0051984)2.46094506
90eye morphogenesis (GO:0048592)2.43861641
91cardiac ventricle formation (GO:0003211)2.40620289
92histone H3-K9 methylation (GO:0051567)2.40450322
93histone H2A monoubiquitination (GO:0035518)2.40066560
94keratinocyte development (GO:0003334)2.38730557
95negative regulation of glial cell proliferation (GO:0060253)2.35316987
96regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.34841440
97lymphangiogenesis (GO:0001946)2.34719452
98regulation of spindle organization (GO:0090224)2.34087726
99chromosome condensation (GO:0030261)2.34031792
100DNA geometric change (GO:0032392)2.33395309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68599990
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.50377216
3AR_21909140_ChIP-Seq_LNCAP_Human4.48062448
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.39757320
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.20696767
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.12883982
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.11761703
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11422669
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99654680
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93493918
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87700178
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.81756887
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.65060745
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47033142
15CLOCK_20551151_ChIP-Seq_293T_Human2.46794086
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.38863827
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.21775677
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.19277308
19ZNF263_19887448_ChIP-Seq_K562_Human2.10341806
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09162603
21ZFX_18555785_ChIP-Seq_MESCs_Mouse2.00707375
22AHR_22903824_ChIP-Seq_MCF-7_Human1.95352387
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92920213
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.92800754
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92158212
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90420019
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.85416725
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83943266
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78496388
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71846597
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62125959
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58658297
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.54594304
34MYC_22102868_ChIP-Seq_BL_Human1.54504916
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51810648
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50652111
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50065187
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.47557869
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44567714
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43406676
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41944778
42CHD1_26751641_Chip-Seq_LNCaP_Human1.39344941
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38717062
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36649793
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36014326
46EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32450548
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32147603
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29144435
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.24481373
50NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24378260
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23855334
52CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23821254
53TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22316730
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.21419713
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20289150
56CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19700284
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18617741
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.18065139
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17066293
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16360633
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15664194
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15246069
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14257764
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.12780073
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12023377
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11146588
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10255204
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.08685310
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08372726
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07693617
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07031133
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.05528253
73XRN2_22483619_ChIP-Seq_HELA_Human1.01642184
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01435077
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00155263
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98459265
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98031368
78TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96480678
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96384414
80ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95160955
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95038722
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94306459
83NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94068434
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93613399
85TTF2_22483619_ChIP-Seq_HELA_Human0.93247072
86GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93152379
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91035706
88REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89629025
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89595206
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89595206
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87079986
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86613759
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85598920
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85364593
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84745607
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83233634
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81946644
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81204880
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81110283
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80903471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure7.83111227
2MP0006292_abnormal_olfactory_placode6.42929085
3MP0002638_abnormal_pupillary_reflex4.02082261
4MP0008057_abnormal_DNA_replication3.76822598
5MP0010234_abnormal_vibrissa_follicle3.31416717
6MP0008789_abnormal_olfactory_epithelium3.10298804
7MP0003941_abnormal_skin_development2.96240897
8MP0005499_abnormal_olfactory_system2.68244185
9MP0005394_taste/olfaction_phenotype2.68244185
10MP0003787_abnormal_imprinting2.51623650
11MP0002938_white_spotting2.29808075
12MP0000428_abnormal_craniofacial_morphol1.98071315
13MP0010352_gastrointestinal_tract_polyps1.85013006
14MP0003705_abnormal_hypodermis_morpholog1.76425249
15MP0004957_abnormal_blastocyst_morpholog1.71720768
16MP0010094_abnormal_chromosome_stability1.65177784
17MP0004185_abnormal_adipocyte_glucose1.64252335
18MP0000613_abnormal_salivary_gland1.64161453
19MP0002009_preneoplasia1.60678535
20MP0002160_abnormal_reproductive_system1.60427873
21MP0000537_abnormal_urethra_morphology1.59662453
22MP0004233_abnormal_muscle_weight1.58350275
23MP0003111_abnormal_nucleus_morphology1.56660474
24MP0008877_abnormal_DNA_methylation1.56501923
25MP0002697_abnormal_eye_size1.54640978
26MP0003077_abnormal_cell_cycle1.53996455
27MP0003693_abnormal_embryo_hatching1.52066879
28MP0005076_abnormal_cell_differentiation1.48131156
29MP0002877_abnormal_melanocyte_morpholog1.37936635
30MP0001730_embryonic_growth_arrest1.37554405
31MP0010678_abnormal_skin_adnexa1.31346295
32MP0002092_abnormal_eye_morphology1.13634932
33MP0001697_abnormal_embryo_size1.11716525
34MP0005197_abnormal_uvea_morphology1.10440946
35MP0008007_abnormal_cellular_replicative1.10189286
36MP0003890_abnormal_embryonic-extraembry1.08863305
37MP0010307_abnormal_tumor_latency1.03861985
38MP0000733_abnormal_muscle_development1.02009714
39MP0004197_abnormal_fetal_growth/weight/1.01588987
40MP0003121_genomic_imprinting1.01399811
41MP0000350_abnormal_cell_proliferation1.00861549
42MP0002084_abnormal_developmental_patter1.00444297
43MP0001340_abnormal_eyelid_morphology0.99863517
44MP0005451_abnormal_body_composition0.99571598
45MP0002177_abnormal_outer_ear0.99445220
46MP0009672_abnormal_birth_weight0.99100766
47MP0009053_abnormal_anal_canal0.98853794
48MP0003935_abnormal_craniofacial_develop0.98598067
49MP0001672_abnormal_embryogenesis/_devel0.98554133
50MP0005380_embryogenesis_phenotype0.98554133
51MP0002086_abnormal_extraembryonic_tissu0.97941986
52MP0004087_abnormal_muscle_fiber0.95647265
53MP0002080_prenatal_lethality0.94610085
54MP0009703_decreased_birth_body0.94234088
55MP0006138_congestive_heart_failure0.92809514
56MP0003221_abnormal_cardiomyocyte_apopto0.92250773
57MP0002089_abnormal_postnatal_growth/wei0.91589979
58MP0008932_abnormal_embryonic_tissue0.91057926
59MP0000003_abnormal_adipose_tissue0.90837537
60MP0000751_myopathy0.90132530
61MP0002088_abnormal_embryonic_growth/wei0.89945977
62MP0009697_abnormal_copulation0.89784224
63MP0003984_embryonic_growth_retardation0.89420848
64MP0003937_abnormal_limbs/digits/tail_de0.88200281
65MP0003755_abnormal_palate_morphology0.86783792
66MP0002796_impaired_skin_barrier0.84869973
67MP0000767_abnormal_smooth_muscle0.84456976
68MP0005623_abnormal_meninges_morphology0.83871834
69MP0010630_abnormal_cardiac_muscle0.83767378
70MP0000747_muscle_weakness0.83580590
71MP0003868_abnormal_feces_composition0.83355995
72MP0005666_abnormal_adipose_tissue0.81655192
73MP0005187_abnormal_penis_morphology0.80517977
74MP0003385_abnormal_body_wall0.80372559
75MP0001661_extended_life_span0.78716907
76MP0000383_abnormal_hair_follicle0.77686985
77MP0002085_abnormal_embryonic_tissue0.77062437
78MP0003115_abnormal_respiratory_system0.76563756
79MP0004808_abnormal_hematopoietic_stem0.75416287
80MP0004036_abnormal_muscle_relaxation0.75172423
81MP0001919_abnormal_reproductive_system0.74912144
82MP0002098_abnormal_vibrissa_morphology0.74870858
83MP0003566_abnormal_cell_adhesion0.74824967
84MP0001286_abnormal_eye_development0.74233735
85MP0004272_abnormal_basement_membrane0.71743298
86MP0004084_abnormal_cardiac_muscle0.71004118
87MP0000762_abnormal_tongue_morphology0.68911872
88MP0005375_adipose_tissue_phenotype0.68425932
89MP0001944_abnormal_pancreas_morphology0.68297987
90MP0008438_abnormal_cutaneous_collagen0.68185770
91MP0000759_abnormal_skeletal_muscle0.67506211
92MP0000377_abnormal_hair_follicle0.66759366
93MP0002269_muscular_atrophy0.65527872
94MP0003699_abnormal_female_reproductive0.64384482
95MP0009780_abnormal_chondrocyte_physiolo0.63950196
96MP0001299_abnormal_eye_distance/0.62838440
97MP0003315_abnormal_perineum_morphology0.62407070
98MP0000749_muscle_degeneration0.61724453
99MP0001348_abnormal_lacrimal_gland0.58160549
100MP0000778_abnormal_nervous_system0.57257977

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)6.77649456
2Aplasia/Hypoplasia of the fovea (HP:0008060)6.77649456
3Difficulty running (HP:0009046)5.91904147
4Abnormality of the fovea (HP:0000493)5.44310797
5Achilles tendon contracture (HP:0001771)5.07505341
6Abnormality of the Achilles tendon (HP:0005109)4.69897353
7Aplasia/Hypoplasia of the macula (HP:0008059)4.63862941
8Aplasia/Hypoplasia affecting the retina (HP:0008061)4.24841544
9Congenital glaucoma (HP:0001087)3.63638218
10Mask-like facies (HP:0000298)3.58503517
11Papillary thyroid carcinoma (HP:0002895)3.49242850
12Hip contracture (HP:0003273)3.16376164
13Scapular winging (HP:0003691)3.01887610
14Relative macrocephaly (HP:0004482)2.81447329
15Optic nerve coloboma (HP:0000588)2.67366976
16Nemaline bodies (HP:0003798)2.66716981
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.66334685
18Muscle fiber inclusion bodies (HP:0100299)2.65733815
19Overlapping toe (HP:0001845)2.63086692
20Generalized hyperpigmentation (HP:0007440)2.60729427
21Biliary tract neoplasm (HP:0100574)2.53914472
22Knee flexion contracture (HP:0006380)2.43459470
23Termporal pattern (HP:0011008)2.33105160
24Insidious onset (HP:0003587)2.33105160
25Limited hip movement (HP:0008800)2.32986309
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29475171
27Medulloblastoma (HP:0002885)2.24861601
28Ankyloglossia (HP:0010296)2.18498301
29Tetraplegia (HP:0002445)2.18158693
30Chromsome breakage (HP:0040012)2.18145697
31Abnormality of the aortic arch (HP:0012303)2.18032569
32Increased connective tissue (HP:0009025)2.16053950
33Rhabdomyosarcoma (HP:0002859)2.13873518
34Thyroid carcinoma (HP:0002890)2.13102091
35Type 1 muscle fiber predominance (HP:0003803)2.09667785
36Neoplasm of the rectum (HP:0100743)2.06276558
37Abnormality of the intrinsic pathway (HP:0010989)2.05287050
38Deep philtrum (HP:0002002)2.04785319
39Neoplasm of the small intestine (HP:0100833)2.04052697
40Dysmetric saccades (HP:0000641)1.98939333
41Abnormality of the shoulder girdle musculature (HP:0001435)1.97849695
42Optic nerve hypoplasia (HP:0000609)1.96340237
43Exercise-induced myalgia (HP:0003738)1.93647566
44Uterine neoplasm (HP:0010784)1.93230496
45Pelvic girdle muscle weakness (HP:0003749)1.93099434
46Asymmetry of the thorax (HP:0001555)1.87567023
47Centrally nucleated skeletal muscle fibers (HP:0003687)1.86520275
48Uterine leiomyosarcoma (HP:0002891)1.84911488
49Leiomyosarcoma (HP:0100243)1.84911488
50Hip dysplasia (HP:0001385)1.84629328
51Right ventricular cardiomyopathy (HP:0011663)1.82224190
52Heterotopia (HP:0002282)1.82065221
53Subaortic stenosis (HP:0001682)1.79313165
54Abnormality of the left ventricular outflow tract (HP:0011103)1.79313165
55Shoulder girdle muscle weakness (HP:0003547)1.78372324
56Increased nuchal translucency (HP:0010880)1.77442411
57Hyperinsulinemic hypoglycemia (HP:0000825)1.72823783
58Esophageal neoplasm (HP:0100751)1.70312871
59Neoplasm of head and neck (HP:0012288)1.70312871
60Osteolytic defects of the hand bones (HP:0009699)1.69108680
61Osteolytic defects of the phalanges of the hand (HP:0009771)1.69108680
62Deviation of the thumb (HP:0009603)1.67057701
63Neonatal hypoglycemia (HP:0001998)1.65357726
64Tetraparesis (HP:0002273)1.65208732
65Missing ribs (HP:0000921)1.64799910
66Microglossia (HP:0000171)1.64318988
67Advanced eruption of teeth (HP:0006288)1.64073471
68Exercise-induced muscle cramps (HP:0003710)1.63879582
69Acute myeloid leukemia (HP:0004808)1.63828413
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61867464
71Sandal gap (HP:0001852)1.61530740
72Germ cell neoplasia (HP:0100728)1.61332607
73Syringomyelia (HP:0003396)1.60894679
74Spinal cord lesions (HP:0100561)1.60894679
75EMG: myopathic abnormalities (HP:0003458)1.60787192
76Atrioventricular canal defect (HP:0006695)1.59284196
77Hyperacusis (HP:0010780)1.59073648
78Insomnia (HP:0100785)1.58563697
79Abnormality of the musculature of the pelvis (HP:0001469)1.57887953
80Abnormality of the hip-girdle musculature (HP:0001445)1.57887953
81Gowers sign (HP:0003391)1.57849555
82Distal lower limb amyotrophy (HP:0008944)1.56446743
83Hyporeflexia of lower limbs (HP:0002600)1.52189944
84Calcaneovalgus deformity (HP:0001848)1.52110725
85Abnormality of oral frenula (HP:0000190)1.51586174
86Proximal placement of thumb (HP:0009623)1.51570544
87Multiple enchondromatosis (HP:0005701)1.49935372
88Back pain (HP:0003418)1.49791812
89Abnormality of chromosome segregation (HP:0002916)1.49723301
90Abnormality of the calcaneus (HP:0008364)1.49607670
91Ridged nail (HP:0001807)1.48360456
92Reduced antithrombin III activity (HP:0001976)1.47544394
93Dental malocclusion (HP:0000689)1.46582986
94Cortical dysplasia (HP:0002539)1.46492639
95High anterior hairline (HP:0009890)1.46396311
96Trismus (HP:0000211)1.42351645
97Spinal rigidity (HP:0003306)1.42309054
98Progressive muscle weakness (HP:0003323)1.42272716
99Nephroblastoma (Wilms tumor) (HP:0002667)1.41723433
100Muscle hypertrophy of the lower extremities (HP:0008968)1.41531451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.42943774
2WEE12.97446338
3ICK2.89076186
4SCYL22.87839043
5MAPK132.60811018
6LATS22.58901028
7RPS6KB22.58798012
8HIPK22.49822268
9SRPK12.39563814
10MAP3K92.36430626
11TTK2.24347950
12PTK2B2.06323903
13EIF2AK32.05911011
14KSR21.96778431
15EIF2AK11.93740750
16PBK1.91472668
17CDK121.89801767
18TSSK61.81909773
19TRIB31.78297192
20LATS11.74371181
21MAP3K101.73683425
22NEK91.69811980
23TTN1.65315882
24MARK11.59044966
25MST1R1.58746422
26IRAK21.57108259
27CDC71.52052124
28NEK11.50739877
29PKN21.49991150
30BRSK21.45279061
31OBSCN1.34224998
32PDGFRA1.32489316
33SMG11.21588232
34RPS6KB11.21275396
35BUB11.12202345
36EPHA21.09500859
37PRPF4B1.08058727
38KSR11.07507446
39CDK61.06023275
40STK241.04628752
41RAF11.04389624
42ARAF1.01102058
43TYRO30.99243823
44CDK70.98563218
45PHKG10.91952112
46PHKG20.91952112
47TAF10.91472992
48BRD40.87919349
49STK30.87450114
50STK38L0.87178008
51BRSK10.84143905
52ERBB40.83943895
53PAK40.83565154
54MET0.83321394
55BRAF0.82741018
56CDK30.81081322
57YES10.79936317
58TRPM70.78916865
59MTOR0.78171174
60CHEK10.69987003
61CHEK20.69882635
62ALK0.69811727
63SGK30.69802246
64MAP3K60.68542890
65MAP3K80.66082772
66MAP2K10.65142346
67MAP3K130.64171385
68EIF2AK20.62205337
69SIK10.60043582
70NEK20.57445405
71AKT20.56655037
72SGK20.55908077
73NTRK10.55252649
74RPS6KA20.53826986
75PLK10.53084731
76IRAK30.52116391
77AURKB0.51813946
78MOS0.51561483
79PAK20.50422564
80CDK10.50324501
81CSNK1E0.50321032
82MARK20.50066568
83CDK20.49546621
84AKT30.48288738
85PNCK0.47649911
86AURKA0.46684793
87MAPK100.46206128
88DMPK0.45156229
89FGFR40.44717227
90PLK40.44147027
91PLK30.43885587
92PAK60.41475810
93PTK20.39843818
94NME20.39342787
95ATM0.37954249
96GSK3B0.37904400
97MKNK10.37319655
98WNK10.35147890
99NEK60.33584999
100RET0.33335576

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.34738538
2Vitamin B6 metabolism_Homo sapiens_hsa007503.08836735
3Pentose phosphate pathway_Homo sapiens_hsa000302.88796194
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73723121
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.67969746
6Biosynthesis of amino acids_Homo sapiens_hsa012302.19659696
7Cell cycle_Homo sapiens_hsa041102.16335877
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.16118060
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97422993
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94650476
11RNA transport_Homo sapiens_hsa030131.87975561
12DNA replication_Homo sapiens_hsa030301.84846566
13Carbon metabolism_Homo sapiens_hsa012001.84530242
14Thyroid cancer_Homo sapiens_hsa052161.73469013
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71418844
16Arginine biosynthesis_Homo sapiens_hsa002201.67651048
17mRNA surveillance pathway_Homo sapiens_hsa030151.63849260
18Pyruvate metabolism_Homo sapiens_hsa006201.56503669
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41021072
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.33915752
21Oocyte meiosis_Homo sapiens_hsa041141.30177064
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.27220234
23Adherens junction_Homo sapiens_hsa045201.18692502
24mTOR signaling pathway_Homo sapiens_hsa041501.18566878
25Endometrial cancer_Homo sapiens_hsa052131.18240495
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16146029
27Insulin signaling pathway_Homo sapiens_hsa049101.15624166
28Chronic myeloid leukemia_Homo sapiens_hsa052201.15486113
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12987668
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11362929
31Steroid biosynthesis_Homo sapiens_hsa001001.09744109
32MicroRNAs in cancer_Homo sapiens_hsa052061.07137073
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04691443
34Long-term potentiation_Homo sapiens_hsa047201.04255152
35Mismatch repair_Homo sapiens_hsa034301.04093763
36Prion diseases_Homo sapiens_hsa050201.02473006
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01889430
38One carbon pool by folate_Homo sapiens_hsa006700.98075639
39Phenylalanine metabolism_Homo sapiens_hsa003600.95488223
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95082409
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93026504
42Prostate cancer_Homo sapiens_hsa052150.92414723
43Focal adhesion_Homo sapiens_hsa045100.91329153
44Glioma_Homo sapiens_hsa052140.91250297
45Spliceosome_Homo sapiens_hsa030400.90701552
46Non-homologous end-joining_Homo sapiens_hsa034500.89841817
47Lysine degradation_Homo sapiens_hsa003100.89194445
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88738685
49Renal cell carcinoma_Homo sapiens_hsa052110.87690240
50Small cell lung cancer_Homo sapiens_hsa052220.87159723
51Hippo signaling pathway_Homo sapiens_hsa043900.85126129
52ErbB signaling pathway_Homo sapiens_hsa040120.84290463
53Other glycan degradation_Homo sapiens_hsa005110.84186513
54Colorectal cancer_Homo sapiens_hsa052100.84179615
55Nucleotide excision repair_Homo sapiens_hsa034200.82632616
56Proteoglycans in cancer_Homo sapiens_hsa052050.82624260
57Alcoholism_Homo sapiens_hsa050340.81710695
58Systemic lupus erythematosus_Homo sapiens_hsa053220.81209598
59AMPK signaling pathway_Homo sapiens_hsa041520.80759686
60Dilated cardiomyopathy_Homo sapiens_hsa054140.79428668
61Pancreatic cancer_Homo sapiens_hsa052120.79293197
62Non-small cell lung cancer_Homo sapiens_hsa052230.79121639
63TGF-beta signaling pathway_Homo sapiens_hsa043500.78667741
64Fructose and mannose metabolism_Homo sapiens_hsa000510.76498144
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.75239878
66Fatty acid biosynthesis_Homo sapiens_hsa000610.74216374
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73744438
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72458790
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69821638
70Bladder cancer_Homo sapiens_hsa052190.69112911
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68060077
72Arginine and proline metabolism_Homo sapiens_hsa003300.67836964
73N-Glycan biosynthesis_Homo sapiens_hsa005100.65626745
74Caffeine metabolism_Homo sapiens_hsa002320.64813726
75Prolactin signaling pathway_Homo sapiens_hsa049170.63581342
76Inositol phosphate metabolism_Homo sapiens_hsa005620.63084570
77Bile secretion_Homo sapiens_hsa049760.61244677
78ECM-receptor interaction_Homo sapiens_hsa045120.59431658
79Glucagon signaling pathway_Homo sapiens_hsa049220.58322912
80Insulin resistance_Homo sapiens_hsa049310.57805813
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57786092
82Viral carcinogenesis_Homo sapiens_hsa052030.56463247
83Wnt signaling pathway_Homo sapiens_hsa043100.55312126
84Basal cell carcinoma_Homo sapiens_hsa052170.52890802
85Tight junction_Homo sapiens_hsa045300.51600990
86Melanogenesis_Homo sapiens_hsa049160.49029747
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48001175
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46560682
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46110665
90Base excision repair_Homo sapiens_hsa034100.41669408
91Thyroid hormone synthesis_Homo sapiens_hsa049180.40912241
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40296505
93Estrogen signaling pathway_Homo sapiens_hsa049150.38528365
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38415145
95p53 signaling pathway_Homo sapiens_hsa041150.38066770
96Fanconi anemia pathway_Homo sapiens_hsa034600.37189785
97HTLV-I infection_Homo sapiens_hsa051660.36927890
98RNA degradation_Homo sapiens_hsa030180.35268022
99Gap junction_Homo sapiens_hsa045400.34341207
100Melanoma_Homo sapiens_hsa052180.33923659

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