TOP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.50635114
2kinetochore organization (GO:0051383)4.00685807
3limb bud formation (GO:0060174)3.86962016
4regulation of RNA export from nucleus (GO:0046831)3.81361377
5regulation of translational fidelity (GO:0006450)3.80745290
6mRNA stabilization (GO:0048255)3.77661925
7RNA stabilization (GO:0043489)3.77661925
8mitotic sister chromatid cohesion (GO:0007064)3.76467256
9protoporphyrinogen IX metabolic process (GO:0046501)3.65813732
10alternative mRNA splicing, via spliceosome (GO:0000380)3.54071431
11DNA strand elongation involved in DNA replication (GO:0006271)3.52741148
12regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52427283
13chromosome condensation (GO:0030261)3.51613171
14DNA duplex unwinding (GO:0032508)3.49519707
15DNA strand elongation (GO:0022616)3.47493764
16folic acid-containing compound biosynthetic process (GO:0009396)3.42346857
17formation of translation preinitiation complex (GO:0001731)3.41939653
18protein-DNA complex disassembly (GO:0032986)3.37453422
19nucleosome disassembly (GO:0006337)3.37453422
20kinetochore assembly (GO:0051382)3.36520317
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.35426319
22* DNA topological change (GO:0006265)3.32907253
23DNA geometric change (GO:0032392)3.31858875
24DNA replication initiation (GO:0006270)3.25472193
25histone H2B ubiquitination (GO:0033523)3.24659925
26mitotic nuclear envelope disassembly (GO:0007077)3.24627035
27mitotic metaphase plate congression (GO:0007080)3.23391233
28regulation of DNA endoreduplication (GO:0032875)3.20917611
29regulation of translational termination (GO:0006449)3.19606655
30ribonucleoprotein complex biogenesis (GO:0022613)3.17245719
31ribosome biogenesis (GO:0042254)3.13121101
323-UTR-mediated mRNA stabilization (GO:0070935)3.13115991
33protein complex localization (GO:0031503)3.12937131
34membrane disassembly (GO:0030397)3.12925695
35nuclear envelope disassembly (GO:0051081)3.12925695
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11476435
37* DNA conformation change (GO:0071103)3.07800902
38cellular protein complex localization (GO:0034629)3.07121095
39microtubule depolymerization (GO:0007019)3.06944929
40protein export from nucleus (GO:0006611)3.05507120
41meiotic chromosome segregation (GO:0045132)3.02299617
42lateral sprouting from an epithelium (GO:0060601)3.01966746
43positive regulation of chromosome segregation (GO:0051984)3.01560767
44metaphase plate congression (GO:0051310)3.01174819
45nuclear pore complex assembly (GO:0051292)3.00170285
46regulation of nucleobase-containing compound transport (GO:0032239)2.99446889
47mRNA splice site selection (GO:0006376)2.97727224
48protein localization to kinetochore (GO:0034501)2.95996360
49pre-miRNA processing (GO:0031054)2.95563274
50glucocorticoid receptor signaling pathway (GO:0042921)2.95361131
51axon ensheathment in central nervous system (GO:0032291)2.94788504
52central nervous system myelination (GO:0022010)2.94788504
53DNA packaging (GO:0006323)2.92396554
54chromatin assembly or disassembly (GO:0006333)2.91171433
55regulation of histone H3-K27 methylation (GO:0061085)2.90421861
56chromatin assembly (GO:0031497)2.90388480
57protein localization to microtubule (GO:0035372)2.87415029
58positive regulation of DNA-dependent DNA replication (GO:2000105)2.87254748
59pattern specification involved in kidney development (GO:0061004)2.86712117
60regulation of mRNA stability (GO:0043488)2.86124727
61negative regulation of mRNA processing (GO:0050686)2.84768147
62telomere maintenance via semi-conservative replication (GO:0032201)2.84707757
63DNA replication checkpoint (GO:0000076)2.84687268
64regulation of sister chromatid cohesion (GO:0007063)2.83546771
65positive regulation of DNA-templated transcription, elongation (GO:0032786)2.83429263
66histone H3-K4 trimethylation (GO:0080182)2.81718756
67DNA strand renaturation (GO:0000733)2.81436713
68ribosome assembly (GO:0042255)2.81435719
69protein localization to chromosome, centromeric region (GO:0071459)2.79474137
70negative regulation of RNA splicing (GO:0033119)2.78366216
71ribosomal small subunit biogenesis (GO:0042274)2.77542839
72nuclear pore organization (GO:0006999)2.76366581
73DNA ligation (GO:0006266)2.76129659
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75592607
75trophoblast giant cell differentiation (GO:0060707)2.74706910
76sister chromatid segregation (GO:0000819)2.73838479
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.72053048
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72053048
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72053048
80notochord development (GO:0030903)2.71564271
81cellular response to virus (GO:0098586)2.71068259
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.70805427
83translational initiation (GO:0006413)2.70384174
84regulation of stem cell maintenance (GO:2000036)2.68312096
85regulation of RNA stability (GO:0043487)2.66995782
86attachment of spindle microtubules to kinetochore (GO:0008608)2.65702668
87regulation of histone methylation (GO:0031060)2.65491821
88mitotic chromosome condensation (GO:0007076)2.64636147
89protoporphyrinogen IX biosynthetic process (GO:0006782)2.64256531
90positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.64057016
91mRNA transport (GO:0051028)2.63677384
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61700883
93mitotic sister chromatid segregation (GO:0000070)2.60296908
94microtubule polymerization or depolymerization (GO:0031109)2.59014442
95DNA unwinding involved in DNA replication (GO:0006268)2.56734390
96regulation of mRNA splicing, via spliceosome (GO:0048024)2.56079446
97regulation of mRNA processing (GO:0050684)2.55470835
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54987914
99cytoplasmic mRNA processing body assembly (GO:0033962)2.53186609
100establishment of integrated proviral latency (GO:0075713)2.51853335
101establishment of chromosome localization (GO:0051303)2.51084951
102regulation of mRNA 3-end processing (GO:0031440)2.50463324
103RNA splicing, via transesterification reactions (GO:0000375)2.47295329
104RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.45738463
105mRNA splicing, via spliceosome (GO:0000398)2.45738463
106positive regulation of mRNA 3-end processing (GO:0031442)2.45219571
107maturation of SSU-rRNA (GO:0030490)2.44734550
108positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.44022821
109positive regulation of histone H3-K4 methylation (GO:0051571)2.43420494
110cell fate commitment involved in formation of primary germ layer (GO:0060795)2.43188276
111CENP-A containing nucleosome assembly (GO:0034080)2.43156654
112DNA replication-independent nucleosome assembly (GO:0006336)2.42130246
113DNA replication-independent nucleosome organization (GO:0034724)2.42130246
114cell proliferation in forebrain (GO:0021846)2.41625510
115centriole replication (GO:0007099)2.39108787
116establishment of mitotic spindle localization (GO:0040001)2.39100397
117peptidyl-lysine trimethylation (GO:0018023)2.38726389
118regulation of spindle organization (GO:0090224)2.38454175
119histone H3-K9 methylation (GO:0051567)2.38052004
120spindle checkpoint (GO:0031577)2.37558897
121regulation of exit from mitosis (GO:0007096)2.37275994
122monoubiquitinated protein deubiquitination (GO:0035520)2.35635258
123pore complex assembly (GO:0046931)2.31343821
124positive regulation of mRNA processing (GO:0050685)2.31185745
125negative regulation of mRNA metabolic process (GO:1903312)2.30782926
126regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.30408125
127chromatin remodeling at centromere (GO:0031055)2.30119800
128viral transcription (GO:0019083)2.29997087
129regulation of centriole replication (GO:0046599)2.29761283
130translational termination (GO:0006415)2.28991747
131histone monoubiquitination (GO:0010390)2.28871450
132spliceosomal complex assembly (GO:0000245)2.27755513
133regulation of mRNA metabolic process (GO:1903311)2.26178552
134regulation of centrosome cycle (GO:0046605)2.25355328
135termination of RNA polymerase II transcription (GO:0006369)2.25249871
136ATP-dependent chromatin remodeling (GO:0043044)2.25233481
137DNA damage response, signal transduction resulting in transcription (GO:0042772)2.24539537
138regulation of mitotic spindle organization (GO:0060236)2.22430391
139female gonad development (GO:0008585)2.21299219
140otic vesicle formation (GO:0030916)2.20230537
141chondrocyte development (GO:0002063)2.18881322
142histone exchange (GO:0043486)2.18461811
143mitotic G2/M transition checkpoint (GO:0044818)2.17278533
144RNA splicing (GO:0008380)2.16952838
145regulation of RNA splicing (GO:0043484)2.16900779
146regulation of histone H3-K9 methylation (GO:0051570)2.16197981
147mitotic spindle checkpoint (GO:0071174)2.15347653
148regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.14965845
149negative regulation of histone methylation (GO:0031061)2.14777141
150establishment of mitotic spindle orientation (GO:0000132)2.14214195
151sister chromatid cohesion (GO:0007062)2.11870019
152regulation of histone H3-K4 methylation (GO:0051569)2.11839771
153protein localization to chromosome (GO:0034502)2.10826399
154regulation of centrosome duplication (GO:0010824)2.09168279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.29283219
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.79727037
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68818489
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67909674
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.41560522
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40543116
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02551675
8MYC_22102868_ChIP-Seq_BL_Human3.02509934
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.92624833
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.87579685
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81307849
12FUS_26573619_Chip-Seq_HEK293_Human2.75762577
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64458165
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56332098
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53616494
16EWS_26573619_Chip-Seq_HEK293_Human2.41433527
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29596061
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12509760
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10973586
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05716403
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04321039
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03872122
23ELK1_19687146_ChIP-ChIP_HELA_Human2.01400615
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96579379
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.96230241
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95821952
27* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.93593609
28AR_21909140_ChIP-Seq_LNCAP_Human1.92922111
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.89084579
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.79552166
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.76104410
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71925942
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67851820
34* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66559120
35ZNF263_19887448_ChIP-Seq_K562_Human1.66355932
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61617929
37* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59241136
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58559425
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55470814
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.54321836
41DCP1A_22483619_ChIP-Seq_HELA_Human1.54135987
42CLOCK_20551151_ChIP-Seq_293T_Human1.53818134
43VDR_21846776_ChIP-Seq_THP-1_Human1.53536732
44* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49299169
45CHD1_26751641_Chip-Seq_LNCaP_Human1.49166217
46AR_21572438_ChIP-Seq_LNCaP_Human1.47952975
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46778740
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46364382
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.45299371
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44595569
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42519383
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41403107
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.39309663
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37536625
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35968378
56TAF15_26573619_Chip-Seq_HEK293_Human1.35615762
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34713907
58KDM5A_27292631_Chip-Seq_BREAST_Human1.34683230
59TTF2_22483619_ChIP-Seq_HELA_Human1.33930969
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30135602
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29220350
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.28853673
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28752434
64RNF2_27304074_Chip-Seq_NSC_Mouse1.28330560
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26428990
66FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24218994
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24108417
68TCF7_22412390_ChIP-Seq_EML_Mouse1.23532508
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22996310
70IGF1R_20145208_ChIP-Seq_DFB_Human1.22976419
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.22862992
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21488707
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.20766227
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20578106
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19704699
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19601697
77* GABP_19822575_ChIP-Seq_HepG2_Human1.18709125
78VDR_22108803_ChIP-Seq_LS180_Human1.18312212
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18076833
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17913626
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.16615414
82CIITA_25753668_ChIP-Seq_RAJI_Human1.16480910
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16472971
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15898359
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14446627
86NCOR1_26117541_ChIP-Seq_K562_Human1.14078591
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14016710
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13884768
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13750177
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13342601
91ATF3_27146783_Chip-Seq_COLON_Human1.12992873
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12857028
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11850610
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11313306
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11294967
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11052779
97* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10996993
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.10817899
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09878373
100RACK7_27058665_Chip-Seq_MCF-7_Human1.09820435
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08118334
102TP53_16413492_ChIP-PET_HCT116_Human1.06920565
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06908902
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06729709
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.06671343
106* ER_23166858_ChIP-Seq_MCF-7_Human1.06437755
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06262698
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05938651
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05890098
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05890098
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.05787552
112* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05444624
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.05341210
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04531293
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04188823
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04049261
117MYC_18940864_ChIP-ChIP_HL60_Human1.03079001
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02929246
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02032828
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01423882
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01346669
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.00724254
123TFEB_21752829_ChIP-Seq_HELA_Human1.00266335
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99287734
125* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98846306
126VDR_23849224_ChIP-Seq_CD4+_Human0.98483907
127* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98230025
128KDM2B_26808549_Chip-Seq_DND41_Human0.96760640
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96617599
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96504521
131ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95929683
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95629955
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95557127
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95554984
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94930927
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94745753
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94598995
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93292301
139* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93091868
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92956659
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92391294
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92200105
143* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92150424
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91845806
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.91666139
146IRF1_19129219_ChIP-ChIP_H3396_Human0.90549219
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89889871
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89889871
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89889871
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.88857875
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88680577
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.88654769
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88427850
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88079175
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87957749
156P300_19829295_ChIP-Seq_ESCs_Human0.86825321
157* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86699910
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86668418
159XRN2_22483619_ChIP-Seq_HELA_Human0.86581267
160SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85316640
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85061267
162KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85020917
163* E2F1_18555785_Chip-Seq_ESCs_Mouse0.84500219
164* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83478740
165LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82444671
166SOX9_26525672_Chip-Seq_HEART_Mouse0.82195788
167* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81628977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.53275795
2MP0002877_abnormal_melanocyte_morpholog3.07653410
3MP0003705_abnormal_hypodermis_morpholog2.51767717
4MP0003693_abnormal_embryo_hatching2.46771115
5MP0010094_abnormal_chromosome_stability2.42206074
6MP0004185_abnormal_adipocyte_glucose2.31614855
7MP0003111_abnormal_nucleus_morphology2.29016122
8MP0003136_yellow_coat_color2.16113999
9MP0003937_abnormal_limbs/digits/tail_de2.15121650
10MP0003077_abnormal_cell_cycle2.14089534
11MP0003656_abnormal_erythrocyte_physiolo2.12057445
12MP0004957_abnormal_blastocyst_morpholog2.10658503
13MP0005451_abnormal_body_composition2.06210587
14MP0002102_abnormal_ear_morphology2.01924965
15MP0004264_abnormal_extraembryonic_tissu2.00999448
16MP0010352_gastrointestinal_tract_polyps1.97091002
17MP0002938_white_spotting1.96179363
18MP0003121_genomic_imprinting1.96095549
19MP0010030_abnormal_orbit_morphology1.95181026
20MP0010234_abnormal_vibrissa_follicle1.94766494
21MP0009250_abnormal_appendicular_skeleto1.94735573
22MP0003787_abnormal_imprinting1.92466932
23MP0000383_abnormal_hair_follicle1.88463252
24MP0008932_abnormal_embryonic_tissue1.87729944
25MP0002796_impaired_skin_barrier1.83622910
26MP0006292_abnormal_olfactory_placode1.82745817
27MP0010307_abnormal_tumor_latency1.81905868
28MP0000566_synostosis1.80043984
29MP0002163_abnormal_gland_morphology1.77529191
30MP0005501_abnormal_skin_physiology1.76096535
31MP0002282_abnormal_trachea_morphology1.75430598
32MP0005171_absent_coat_pigmentation1.66553772
33MP0003755_abnormal_palate_morphology1.66525072
34MP0003385_abnormal_body_wall1.65689839
35MP0003453_abnormal_keratinocyte_physiol1.64726195
36MP0003315_abnormal_perineum_morphology1.64483199
37MP0003566_abnormal_cell_adhesion1.64151412
38MP0003938_abnormal_ear_development1.64129427
39MP0004808_abnormal_hematopoietic_stem1.63025995
40* MP0002080_prenatal_lethality1.62561043
41MP0002396_abnormal_hematopoietic_system1.60972537
42MP0003890_abnormal_embryonic-extraembry1.58882746
43MP0008877_abnormal_DNA_methylation1.55897886
44MP0003123_paternal_imprinting1.54201803
45MP0000537_abnormal_urethra_morphology1.50710842
46MP0000432_abnormal_head_morphology1.48064607
47MP0008058_abnormal_DNA_repair1.47383020
48MP0009672_abnormal_birth_weight1.47152663
49MP0001346_abnormal_lacrimal_gland1.43563491
50MP0000049_abnormal_middle_ear1.41472906
51MP0000778_abnormal_nervous_system1.41467252
52MP0008007_abnormal_cellular_replicative1.41033755
53MP0000350_abnormal_cell_proliferation1.37154615
54MP0010678_abnormal_skin_adnexa1.35817454
55MP0009697_abnormal_copulation1.34646293
56MP0000762_abnormal_tongue_morphology1.33316167
57MP0000313_abnormal_cell_death1.32247273
58MP0001293_anophthalmia1.31407631
59MP0002084_abnormal_developmental_patter1.28475442
60MP0000579_abnormal_nail_morphology1.28417174
61MP0004233_abnormal_muscle_weight1.27442866
62MP0001286_abnormal_eye_development1.26373539
63MP0002085_abnormal_embryonic_tissue1.26321270
64MP0002116_abnormal_craniofacial_bone1.26090897
65MP0004134_abnormal_chest_morphology1.25385201
66MP0005076_abnormal_cell_differentiation1.23693945
67MP0005409_darkened_coat_color1.23638615
68MP0009379_abnormal_foot_pigmentation1.23188319
69MP0002249_abnormal_larynx_morphology1.23107551
70MP0003935_abnormal_craniofacial_develop1.22481934
71MP0000490_abnormal_crypts_of1.21519522
72MP0004197_abnormal_fetal_growth/weight/1.19579691
73MP0002098_abnormal_vibrissa_morphology1.16577030
74MP0004742_abnormal_vestibular_system1.16448308
75MP0000462_abnormal_digestive_system1.16028647
76MP0002233_abnormal_nose_morphology1.15971014
77MP0000627_abnormal_mammary_gland1.14030086
78MP0003950_abnormal_plasma_membrane1.13094384
79MP0003861_abnormal_nervous_system1.12746850
80MP0001727_abnormal_embryo_implantation1.12354769
81MP0002932_abnormal_joint_morphology1.12181241
82MP0001485_abnormal_pinna_reflex1.11398092
83MP0000733_abnormal_muscle_development1.10763623
84MP0003941_abnormal_skin_development1.10479457
85MP0003567_abnormal_fetal_cardiomyocyte1.10204067
86MP0005379_endocrine/exocrine_gland_phen1.09982474
87MP0006072_abnormal_retinal_apoptosis1.09062740
88MP0000428_abnormal_craniofacial_morphol1.08467466
89MP0005380_embryogenesis_phenotype1.08048238
90MP0001672_abnormal_embryogenesis/_devel1.08048238
91MP0001216_abnormal_epidermal_layer1.07175898
92MP0001697_abnormal_embryo_size1.05796919
93MP0001730_embryonic_growth_arrest1.05571836
94MP0005621_abnormal_cell_physiology1.04817127
95MP0001881_abnormal_mammary_gland1.01798464
96MP0002114_abnormal_axial_skeleton1.01712925
97MP0003942_abnormal_urinary_system1.01210189
98MP0002177_abnormal_outer_ear1.01083250
99MP0005666_abnormal_adipose_tissue1.00320846
100MP0001340_abnormal_eyelid_morphology1.00028043
101MP0002697_abnormal_eye_size0.99972046
102MP0004381_abnormal_hair_follicle0.98777021
103MP0008789_abnormal_olfactory_epithelium0.98566461
104MP0002006_tumorigenesis0.97017144
105MP0004782_abnormal_surfactant_physiolog0.95497121
106MP0002111_abnormal_tail_morphology0.95380849
107MP0002109_abnormal_limb_morphology0.94519047
108MP0002277_abnormal_respiratory_mucosa0.93716555
109MP0001188_hyperpigmentation0.92966654
110MP0009053_abnormal_anal_canal0.92163969
111MP0003221_abnormal_cardiomyocyte_apopto0.92160713
112MP0000163_abnormal_cartilage_morphology0.91972131
113MP0002933_joint_inflammation0.91931801
114MP0003718_maternal_effect0.91927007
115MP0002166_altered_tumor_susceptibility0.91761926
116MP0005384_cellular_phenotype0.91736532
117MP0002113_abnormal_skeleton_development0.90661089
118MP0000678_abnormal_parathyroid_gland0.90504606
119MP0003984_embryonic_growth_retardation0.89832225
120MP0002092_abnormal_eye_morphology0.89068157
121MP0001299_abnormal_eye_distance/0.88481216
122MP0002088_abnormal_embryonic_growth/wei0.88464499
123MP0002089_abnormal_postnatal_growth/wei0.86982459
124MP0002751_abnormal_autonomic_nervous0.86362349
125MP0000631_abnormal_neuroendocrine_gland0.86176703
126MP0000377_abnormal_hair_follicle0.85132926
127MP0003115_abnormal_respiratory_system0.85082099
128MP0001851_eye_inflammation0.83632907
129MP0001849_ear_inflammation0.83245648
130MP0005174_abnormal_tail_pigmentation0.83235041
131MP0000569_abnormal_digit_pigmentation0.82698063
132MP0000647_abnormal_sebaceous_gland0.82105512
133MP0000858_altered_metastatic_potential0.81898544
134MP0002086_abnormal_extraembryonic_tissu0.81687376
135MP0005248_abnormal_Harderian_gland0.81297033
136MP0009278_abnormal_bone_marrow0.81159549
137MP0005083_abnormal_biliary_tract0.81040769
138MP0001529_abnormal_vocalization0.80478614
139MP0002060_abnormal_skin_morphology0.79870586
140MP0005508_abnormal_skeleton_morphology0.79843137
141MP0009703_decreased_birth_body0.78624551
142MP0009931_abnormal_skin_appearance0.78581706
143MP0002081_perinatal_lethality0.77321313
144MP0002019_abnormal_tumor_incidence0.77266863
145MP0002009_preneoplasia0.76734262
146MP0005397_hematopoietic_system_phenotyp0.71413956
147MP0001545_abnormal_hematopoietic_system0.71413956
148MP0008961_abnormal_basal_metabolism0.70942389
149MP0003303_peritoneal_inflammation0.70927175
150MP0008260_abnormal_autophagy0.69843448
151MP0003091_abnormal_cell_migration0.64539800

Predicted human phenotypes

RankGene SetZ-score
1Small epiphyses (HP:0010585)4.00931078
2Epiphyseal dysplasia (HP:0002656)3.87383243
3Irregular epiphyses (HP:0010582)3.77029535
4Insomnia (HP:0100785)3.69397855
5Increased nuchal translucency (HP:0010880)3.42945910
6Hyperacusis (HP:0010780)3.30133820
7Hypoplastic ischia (HP:0003175)3.08764209
8Vitreoretinal degeneration (HP:0000655)3.05120221
9Volvulus (HP:0002580)3.04404383
10Missing ribs (HP:0000921)2.95652094
11Overlapping toe (HP:0001845)2.88443539
12Deep palmar crease (HP:0006191)2.73621062
13Abnormality of reticulocytes (HP:0004312)2.73380641
14Delayed epiphyseal ossification (HP:0002663)2.71708240
15Deep philtrum (HP:0002002)2.65143023
16Reticulocytosis (HP:0001923)2.64162957
17Asymmetry of the thorax (HP:0001555)2.61271835
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58507644
19Abnormality of the ischium (HP:0003174)2.52729218
20Abnormality of cells of the erythroid lineage (HP:0012130)2.51187539
21Chin dimple (HP:0010751)2.50944038
22Termporal pattern (HP:0011008)2.50929107
23Insidious onset (HP:0003587)2.50929107
24Flat capital femoral epiphysis (HP:0003370)2.46989440
25Cortical dysplasia (HP:0002539)2.46851008
2611 pairs of ribs (HP:0000878)2.45682271
27Facial hemangioma (HP:0000329)2.45443199
28Metaphyseal dysplasia (HP:0100255)2.45379353
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39678762
30Elfin facies (HP:0004428)2.38975977
31Long palpebral fissure (HP:0000637)2.38331615
32Abnormality of the phalanges of the 2nd finger (HP:0009541)2.37286281
33Parakeratosis (HP:0001036)2.36961955
34Overriding aorta (HP:0002623)2.35375790
35Multiple enchondromatosis (HP:0005701)2.35227256
36Hypoplastic pelvis (HP:0008839)2.33929540
37High anterior hairline (HP:0009890)2.33495882
38Chromsome breakage (HP:0040012)2.28589516
39Ectopic kidney (HP:0000086)2.28512306
40Pallor (HP:0000980)2.28168617
41Long eyelashes (HP:0000527)2.25625793
42Septate vagina (HP:0001153)2.24758285
43Birth length less than 3rd percentile (HP:0003561)2.24579211
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22663008
45Absent epiphyses (HP:0010577)2.22663008
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.22499452
47Limited elbow extension (HP:0001377)2.21937065
48Abnormality of incisor morphology (HP:0011063)2.21894111
49Cupped ear (HP:0000378)2.21478930
50Leiomyosarcoma (HP:0100243)2.20071538
51Uterine leiomyosarcoma (HP:0002891)2.20071538
52Patellar dislocation (HP:0002999)2.19531010
53Ankyloglossia (HP:0010296)2.16571831
54Abnormality of chromosome segregation (HP:0002916)2.15975930
55Nephroblastoma (Wilms tumor) (HP:0002667)2.15341615
56Supernumerary ribs (HP:0005815)2.14308010
57Obsessive-compulsive behavior (HP:0000722)2.14306076
58Genu varum (HP:0002970)2.13074581
59Abnormality of the gastric mucosa (HP:0004295)2.13002475
60Adrenal hypoplasia (HP:0000835)2.12699272
61Macrocytic anemia (HP:0001972)2.12460218
62Renal duplication (HP:0000075)2.12211063
63Abnormality of the parietal bone (HP:0002696)2.11876940
64Abnormality of the incisor (HP:0000676)2.11075238
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10478456
66Heterotopia (HP:0002282)2.10168525
67Short middle phalanx of the 5th finger (HP:0004220)2.09688652
68Bladder neoplasm (HP:0009725)2.08638972
69Bladder carcinoma (HP:0002862)2.08638972
70Stenosis of the external auditory canal (HP:0000402)2.08021460
71Pseudobulbar signs (HP:0002200)2.06543055
72Transitional cell carcinoma of the bladder (HP:0006740)2.06151829
73Macroorchidism (HP:0000053)2.05687138
74Oligodactyly (hands) (HP:0001180)2.04501864
75Supernumerary bones of the axial skeleton (HP:0009144)2.03479678
76Progressive external ophthalmoplegia (HP:0000590)2.01569674
77Abnormality of the septum pellucidum (HP:0007375)2.00520833
78Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00337554
79Achilles tendon contracture (HP:0001771)2.00058031
80Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.99751301
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.99681475
82Embryonal renal neoplasm (HP:0011794)1.99502095
83Aplasia cutis congenita (HP:0001057)1.98562605
84Gastrointestinal carcinoma (HP:0002672)1.97963483
85Malignant gastrointestinal tract tumors (HP:0006749)1.97963483
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96727085
87Abnormality of nail color (HP:0100643)1.95837755
88Patellar aplasia (HP:0006443)1.94718543
89Poikilocytosis (HP:0004447)1.94053742
90Trismus (HP:0000211)1.93671131
91Microglossia (HP:0000171)1.93317198
92Glossoptosis (HP:0000162)1.91200591
93Short middle phalanx of finger (HP:0005819)1.90923959
94Abnormality of the nasal septum (HP:0000419)1.90742854
95Absent radius (HP:0003974)1.90648503
96Blepharitis (HP:0000498)1.90430077
97Absent septum pellucidum (HP:0001331)1.90189966
98Progressive muscle weakness (HP:0003323)1.89591512
99Esophageal atresia (HP:0002032)1.89254849
100Abnormality of the preputium (HP:0100587)1.89105234
101Selective tooth agenesis (HP:0001592)1.89031794
102Cafe-au-lait spot (HP:0000957)1.88972037
103Abnormality of the intervertebral disk (HP:0005108)1.88551098
104Aplasia/Hypoplasia of the patella (HP:0006498)1.87896496
105Midline defect of the nose (HP:0004122)1.87077010
106Oligodactyly (HP:0012165)1.86874590
107Abnormal number of incisors (HP:0011064)1.86270450
108Orthostatic hypotension (HP:0001278)1.85802779
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.85787011
110Abnormality of femoral epiphyses (HP:0006499)1.85787011
111Mild short stature (HP:0003502)1.85231855
112Cupped ribs (HP:0000887)1.84684124
113Abnormality of the phalanges of the 5th finger (HP:0004213)1.84068095
114Septo-optic dysplasia (HP:0100842)1.83331228
115Vertebral arch anomaly (HP:0008438)1.82301527
116Rib fusion (HP:0000902)1.82128696
117Squamous cell carcinoma (HP:0002860)1.81624640
118Flattened epiphyses (HP:0003071)1.81563787
119Abnormal foot bone ossification (HP:0010675)1.80553870
120Long clavicles (HP:0000890)1.79520589
121Absent forearm bone (HP:0003953)1.79196087
122Aplasia involving forearm bones (HP:0009822)1.79196087
123Mixed hearing impairment (HP:0000410)1.79034743
124Hypoparathyroidism (HP:0000829)1.78844869
125Proximal placement of thumb (HP:0009623)1.78299463
126Abnormality of the carotid arteries (HP:0005344)1.77827581
127Abnormality of the labia minora (HP:0012880)1.77341542
128Horseshoe kidney (HP:0000085)1.77229589
129Low posterior hairline (HP:0002162)1.76639011
130Myelodysplasia (HP:0002863)1.75843091
131Flat acetabular roof (HP:0003180)1.75830979
132Abnormality of the phalanges of the hallux (HP:0010057)1.75801894
133Abnormality of the epiphysis of the femoral head (HP:0010574)1.75467507
134Diaphragmatic weakness (HP:0009113)1.75337549
135Concave nail (HP:0001598)1.74912589
136Abnormality of the 2nd finger (HP:0004100)1.74547315
137Myelomeningocele (HP:0002475)1.74353794
138Arnold-Chiari malformation (HP:0002308)1.74100113
139Preauricular skin tag (HP:0000384)1.73851787
140Diastasis recti (HP:0001540)1.73655794
141Renovascular hypertension (HP:0100817)1.73459673
142Abnormality of the Achilles tendon (HP:0005109)1.73287769
143Curly hair (HP:0002212)1.73054068
144Microtia (HP:0008551)1.72418564
145Deviation of the thumb (HP:0009603)1.72234012
146Abnormal number of erythroid precursors (HP:0012131)1.72161939
147Acute myeloid leukemia (HP:0004808)1.71655385
148Breast hypoplasia (HP:0003187)1.71593151
149Subacute progressive viral hepatitis (HP:0006572)1.71379602
150Abnormal sex determination (HP:0012244)1.71340439
151Sex reversal (HP:0012245)1.71340439
152Sandal gap (HP:0001852)1.70714012
153Low anterior hairline (HP:0000294)1.70694350
154Urethral obstruction (HP:0000796)1.70661265
155Sparse lateral eyebrow (HP:0005338)1.70210580
156Abnormality of the vertebral endplates (HP:0005106)1.68025677
157Abnormality of the salivary glands (HP:0010286)1.67924742
158Absent frontal sinuses (HP:0002688)1.67400770
159Ridged nail (HP:0001807)1.67311116
160Skull defect (HP:0001362)1.66776422
161Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65875748
162Reticulocytopenia (HP:0001896)1.65540277
163Abnormality of the fingertips (HP:0001211)1.65531587
164Abnormality of the femoral head (HP:0003368)1.62394068
165Hypoplastic iliac wings (HP:0002866)1.62048680
166Aplasia/Hypoplasia of the sternum (HP:0006714)1.61626212
167Enlarged epiphyses (HP:0010580)1.59080563
168White forelock (HP:0002211)1.58858136
169Short thumb (HP:0009778)1.58567711
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.56523684
171Abnormal lung lobation (HP:0002101)1.54449715
172Broad thumb (HP:0011304)1.54187110
173Tracheomalacia (HP:0002779)1.53537706
174Abnormality of the columella (HP:0009929)1.52279717
175Submucous cleft hard palate (HP:0000176)1.52174028
176Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.51860339
177Prostate neoplasm (HP:0100787)1.50828455
178Supernumerary spleens (HP:0009799)1.50568242
179Capillary hemangiomas (HP:0005306)1.49680509
180Atresia of the external auditory canal (HP:0000413)1.49461247
181Abnormal vertebral ossification (HP:0100569)1.48715513
182Abnormality of chromosome stability (HP:0003220)1.48079227
183Short 4th metacarpal (HP:0010044)1.47013541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.58546527
2MKNK13.55506939
3CDC73.30279450
4SMG12.98396920
5CDK122.78086648
6MAP3K102.73674237
7ICK2.69185493
8PNCK2.55935124
9SRPK12.44587498
10BRD42.41888312
11TRIB32.28674959
12LATS12.27914654
13PBK2.24805168
14IRAK32.06835602
15EEF2K1.96659718
16PRPF4B1.92589786
17EPHA21.86742082
18SIK11.83859962
19PLK41.68233943
20STK31.68052271
21STK391.65153019
22MAP3K91.60169094
23SCYL21.55614330
24NUAK11.53319225
25MST41.53127190
26MST1R1.50668870
27NME21.50417462
28WEE11.47779017
29PLK31.47741062
30FGFR41.47328478
31CAMK1D1.41832301
32MELK1.39895030
33BCR1.39172840
34DYRK31.37926346
35TTK1.37819805
36TAF11.32376394
37FGR1.32152885
38CHEK21.30234940
39BUB11.27931338
40DYRK21.26510742
41CAMK1G1.23683806
42MTOR1.23517291
43CDK61.22696898
44STK101.21757623
45AURKB1.17921040
46CDK31.16300896
47CDK91.15869569
48CDK71.15298011
49VRK11.12990822
50CHEK11.12012851
51NEK21.08127698
52TAOK21.06169501
53CSNK1A1L1.04823088
54EIF2AK21.03522111
55ATM1.02087283
56PDGFRA1.01878493
57PLK11.00953695
58DDR21.00686153
59RPS6KA50.99088733
60NEK10.97535290
61PLK20.97516359
62STK40.95136077
63TNIK0.94402968
64CLK10.92998477
65CSNK1G10.92278926
66ATR0.91212787
67TYRO30.90458345
68ERN10.89554750
69ERBB30.89200097
70LRRK20.88548553
71EPHB20.88367571
72EIF2AK10.86157160
73WNK10.85981301
74NEK60.83816596
75YES10.82225767
76TLK10.82034114
77STK38L0.80969923
78TAOK10.79618072
79CDK80.78219860
80ERBB40.78089420
81RPS6KA40.78049973
82MAP3K140.77963637
83TSSK60.77481852
84* CDK10.77205584
85PDGFRB0.77150843
86BRAF0.75175849
87PKN10.74744565
88CDK20.73921163
89FGFR20.73837853
90BRSK20.72464927
91DMPK0.72441954
92CSNK1E0.72330936
93PKN20.71960971
94IRAK40.71615314
95CDK40.70832261
96UHMK10.70738087
97CHUK0.70477206
98NLK0.69616433
99DYRK1A0.69532355
100CSNK1G30.68905201
101KSR10.68813030
102OXSR10.67881872
103PIM10.67746694
104CASK0.66973784
105PTK60.66740910
106MOS0.66434866
107EIF2AK30.65916326
108PASK0.65510510
109EPHB10.64329624
110MAP3K80.64151887
111PAK40.63682108
112BMPR1B0.63060170
113PTK20.61785158
114CSNK1D0.60774425
115TRPM70.60650003
116BMPR20.59116397
117LATS20.58470576
118MAPK130.56480531
119MAPK140.56394300
120MET0.56016309
121SIK30.56011457
122MAP3K60.55209552
123IRAK20.54960207
124RIPK10.52979527
125AURKA0.50852650
126RPS6KB20.50819580
127CDK11A0.50379505
128CSNK2A20.50184024
129GSK3A0.49838932
130BRSK10.48892600
131PAK20.48342903
132STK240.48160211
133PRKDC0.47800772
134MAPK100.47635394
135BMX0.47109423
136CDK150.47027727
137ALK0.46790780
138CDK140.46473004
139AKT20.46099173
140ROCK20.45790453
141MAP3K130.45776205
142CDK180.45458812
143TAOK30.45313256
144SIK20.44872208
145KSR20.44826317
146MAPKAPK50.43732230
147GSK3B0.41873483
148AKT10.41850962

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.76979139
2Thyroid cancer_Homo sapiens_hsa052162.34709336
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30327397
4Cell cycle_Homo sapiens_hsa041102.24636108
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15567438
6Basal transcription factors_Homo sapiens_hsa030222.12805756
7RNA polymerase_Homo sapiens_hsa030202.12264529
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01277155
9Ribosome_Homo sapiens_hsa030101.98671230
10Non-homologous end-joining_Homo sapiens_hsa034501.97013629
11Bladder cancer_Homo sapiens_hsa052191.92535482
12RNA transport_Homo sapiens_hsa030131.92152458
13Fanconi anemia pathway_Homo sapiens_hsa034601.89845391
14mRNA surveillance pathway_Homo sapiens_hsa030151.89564832
15Homologous recombination_Homo sapiens_hsa034401.82316090
16RNA degradation_Homo sapiens_hsa030181.67796830
17Non-small cell lung cancer_Homo sapiens_hsa052231.64786428
18Nucleotide excision repair_Homo sapiens_hsa034201.58157985
19Endometrial cancer_Homo sapiens_hsa052131.55981226
20MicroRNAs in cancer_Homo sapiens_hsa052061.54195583
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53338034
22Mismatch repair_Homo sapiens_hsa034301.52895353
23DNA replication_Homo sapiens_hsa030301.48111002
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46253939
25Acute myeloid leukemia_Homo sapiens_hsa052211.41626004
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.39317768
27TGF-beta signaling pathway_Homo sapiens_hsa043501.35934345
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30418389
29Basal cell carcinoma_Homo sapiens_hsa052171.29006000
30p53 signaling pathway_Homo sapiens_hsa041151.28861732
31Steroid biosynthesis_Homo sapiens_hsa001001.21869698
32Axon guidance_Homo sapiens_hsa043601.18383330
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17499052
34Hedgehog signaling pathway_Homo sapiens_hsa043401.15662602
35Wnt signaling pathway_Homo sapiens_hsa043101.12481080
36Hippo signaling pathway_Homo sapiens_hsa043901.12142655
37Systemic lupus erythematosus_Homo sapiens_hsa053221.11407801
38Graft-versus-host disease_Homo sapiens_hsa053321.09345173
39Base excision repair_Homo sapiens_hsa034101.06486494
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06284498
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05819579
42Autoimmune thyroid disease_Homo sapiens_hsa053201.05079100
43Prostate cancer_Homo sapiens_hsa052151.05010041
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.03197584
45Glioma_Homo sapiens_hsa052141.01973607
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01181532
47ECM-receptor interaction_Homo sapiens_hsa045121.00818685
48Asthma_Homo sapiens_hsa053101.00724518
49Epstein-Barr virus infection_Homo sapiens_hsa051691.00117304
50Herpes simplex infection_Homo sapiens_hsa051680.97035505
51Small cell lung cancer_Homo sapiens_hsa052220.96333803
52Sphingolipid metabolism_Homo sapiens_hsa006000.95849091
53Allograft rejection_Homo sapiens_hsa053300.93448417
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93198205
55Renal cell carcinoma_Homo sapiens_hsa052110.92735387
56VEGF signaling pathway_Homo sapiens_hsa043700.92637701
57Protein export_Homo sapiens_hsa030600.92011149
58Viral carcinogenesis_Homo sapiens_hsa052030.90653975
59Ether lipid metabolism_Homo sapiens_hsa005650.90605321
60Prion diseases_Homo sapiens_hsa050200.90188165
61Prolactin signaling pathway_Homo sapiens_hsa049170.89597010
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89445378
63Adherens junction_Homo sapiens_hsa045200.89222767
64Hepatitis C_Homo sapiens_hsa051600.88488214
65Lysine degradation_Homo sapiens_hsa003100.87134078
66Hematopoietic cell lineage_Homo sapiens_hsa046400.87031289
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86178710
68HTLV-I infection_Homo sapiens_hsa051660.84695046
69Malaria_Homo sapiens_hsa051440.84594540
70Biosynthesis of amino acids_Homo sapiens_hsa012300.84528562
71Colorectal cancer_Homo sapiens_hsa052100.84308218
72Chronic myeloid leukemia_Homo sapiens_hsa052200.81361518
73Dorso-ventral axis formation_Homo sapiens_hsa043200.80321382
74Viral myocarditis_Homo sapiens_hsa054160.80245606
75Phototransduction_Homo sapiens_hsa047440.79909286
76Oocyte meiosis_Homo sapiens_hsa041140.79333411
77Hepatitis B_Homo sapiens_hsa051610.78565766
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78005219
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76878340
80Notch signaling pathway_Homo sapiens_hsa043300.76838525
81T cell receptor signaling pathway_Homo sapiens_hsa046600.76389764
82Pancreatic cancer_Homo sapiens_hsa052120.76037860
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74969324
84Measles_Homo sapiens_hsa051620.73707389
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.73098381
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72358138
87Influenza A_Homo sapiens_hsa051640.72258452
88Pathways in cancer_Homo sapiens_hsa052000.71672984
89Insulin signaling pathway_Homo sapiens_hsa049100.71450249
90mTOR signaling pathway_Homo sapiens_hsa041500.69844776
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69251741
92Proteasome_Homo sapiens_hsa030500.68035542
93Pyrimidine metabolism_Homo sapiens_hsa002400.67427244
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.66584219
95HIF-1 signaling pathway_Homo sapiens_hsa040660.66170919
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61986798
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61695243
98Proteoglycans in cancer_Homo sapiens_hsa052050.60941314
99Pentose phosphate pathway_Homo sapiens_hsa000300.60907753
100Primary immunodeficiency_Homo sapiens_hsa053400.60450044
101ErbB signaling pathway_Homo sapiens_hsa040120.59695820
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59693020
103AMPK signaling pathway_Homo sapiens_hsa041520.59173653
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59140847
105Alcoholism_Homo sapiens_hsa050340.58340864
106Melanoma_Homo sapiens_hsa052180.57833490
107B cell receptor signaling pathway_Homo sapiens_hsa046620.57543040
108Tight junction_Homo sapiens_hsa045300.56885990
109Sulfur relay system_Homo sapiens_hsa041220.56220117
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55745019
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54813939
112FoxO signaling pathway_Homo sapiens_hsa040680.52070605
113MAPK signaling pathway_Homo sapiens_hsa040100.51264799
114Osteoclast differentiation_Homo sapiens_hsa043800.50884020
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.50863595
116Focal adhesion_Homo sapiens_hsa045100.49612301
117TNF signaling pathway_Homo sapiens_hsa046680.48460221
118Apoptosis_Homo sapiens_hsa042100.48457998
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.48194061
120Ras signaling pathway_Homo sapiens_hsa040140.47935331
121Shigellosis_Homo sapiens_hsa051310.47159726
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46688863
123Fatty acid biosynthesis_Homo sapiens_hsa000610.46628552
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46451523
125Choline metabolism in cancer_Homo sapiens_hsa052310.46075900
126Antigen processing and presentation_Homo sapiens_hsa046120.45860990
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45641767
128One carbon pool by folate_Homo sapiens_hsa006700.45299308
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44240705
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44122887
131Long-term depression_Homo sapiens_hsa047300.44056949
132Estrogen signaling pathway_Homo sapiens_hsa049150.43735699
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.43324518
134Leishmaniasis_Homo sapiens_hsa051400.41596718
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41435924
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41428298
137Carbon metabolism_Homo sapiens_hsa012000.37457661
138Folate biosynthesis_Homo sapiens_hsa007900.35640809

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