ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to kinetochore (GO:0034501)	6.11142801
2	mitotic chromosome condensation (GO:0007076)	5.78572519
3	nuclear pore complex assembly (GO:0051292)	5.52821917
4	nuclear pore organization (GO:0006999)	5.47497382
5	kinetochore organization (GO:0051383)	5.39903353
6	mitotic sister chromatid segregation (GO:0000070)	5.34601834
7	protein localization to chromosome, centromeric region (GO:0071459)	5.23728661
8	* sister chromatid segregation (GO:0000819)	5.10175925
9	mitotic sister chromatid cohesion (GO:0007064)	4.84333832
10	* DNA unwinding involved in DNA replication (GO:0006268)	4.80455099
11	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.76245902
12	mitotic metaphase plate congression (GO:0007080)	4.75112624
13	attachment of spindle microtubules to kinetochore (GO:0008608)	4.67317525
14	metaphase plate congression (GO:0051310)	4.52197956
15	DNA replication-dependent nucleosome organization (GO:0034723)	4.49923487
16	DNA replication-dependent nucleosome assembly (GO:0006335)	4.49923487
17	chromatin remodeling at centromere (GO:0031055)	4.49181485
18	CENP-A containing nucleosome assembly (GO:0034080)	4.47356260
19	regulation of spindle organization (GO:0090224)	4.43976343
20	DNA strand elongation involved in DNA replication (GO:0006271)	4.40042951
21	mitotic nuclear envelope disassembly (GO:0007077)	4.37149049
22	DNA replication initiation (GO:0006270)	4.34369082
23	kinetochore assembly (GO:0051382)	4.28694373
24	meiotic chromosome segregation (GO:0045132)	4.26426697
25	pore complex assembly (GO:0046931)	4.24047914
26	establishment of chromosome localization (GO:0051303)	4.20386711
27	DNA replication-independent nucleosome assembly (GO:0006336)	4.19304600
28	DNA replication-independent nucleosome organization (GO:0034724)	4.19304600
29	DNA strand elongation (GO:0022616)	4.17499901
30	telomere maintenance via semi-conservative replication (GO:0032201)	4.12631289
31	nuclear envelope disassembly (GO:0051081)	4.09527774
32	membrane disassembly (GO:0030397)	4.09527774
33	positive regulation of chromosome segregation (GO:0051984)	4.09485911
34	regulation of mitotic spindle organization (GO:0060236)	4.08439057
35	regulation of histone H3-K9 methylation (GO:0051570)	4.08071961
36	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.98568048
37	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.98568048
38	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.98568048
39	establishment of integrated proviral latency (GO:0075713)	3.95579964
40	* DNA ligation (GO:0006266)	3.92598792
41	telomere maintenance via recombination (GO:0000722)	3.91093529
42	* mitotic recombination (GO:0006312)	3.89601407
43	histone exchange (GO:0043486)	3.89162115
44	regulation of chromosome segregation (GO:0051983)	3.88609826
45	regulation of sister chromatid cohesion (GO:0007063)	3.88607286
46	protein localization to chromosome (GO:0034502)	3.88446958
47	spindle checkpoint (GO:0031577)	3.86002060
48	* DNA geometric change (GO:0032392)	3.84769232
49	* DNA duplex unwinding (GO:0032508)	3.83837601
50	regulation of DNA endoreduplication (GO:0032875)	3.81294006
51	chromatin assembly or disassembly (GO:0006333)	3.80357690
52	DNA replication checkpoint (GO:0000076)	3.72635806
53	regulation of centriole replication (GO:0046599)	3.72206863
54	* chromosome segregation (GO:0007059)	3.69999069
55	spindle assembly checkpoint (GO:0071173)	3.69790620
56	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.67459530
57	regulation of centrosome cycle (GO:0046605)	3.65212846
58	* chromosome condensation (GO:0030261)	3.65107493
59	negative regulation of mitosis (GO:0045839)	3.60895782
60	mitotic G2/M transition checkpoint (GO:0044818)	3.60224518
61	mitotic spindle organization (GO:0007052)	3.59853330
62	negative regulation of chromosome segregation (GO:0051985)	3.58857144
63	mitotic cytokinesis (GO:0000281)	3.58530976
64	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.58106380
65	negative regulation of sister chromatid segregation (GO:0033046)	3.54975161
66	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.54975161
67	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.54975161
68	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.54975161
69	* DNA conformation change (GO:0071103)	3.52631816
70	negative regulation of histone methylation (GO:0031061)	3.51049169
71	mitotic spindle checkpoint (GO:0071174)	3.50828121
72	establishment of mitotic spindle localization (GO:0040001)	3.50731274
73	mitotic spindle assembly checkpoint (GO:0007094)	3.49956847
74	regulation of mitotic sister chromatid separation (GO:0010965)	3.49895810
75	regulation of mitotic sister chromatid segregation (GO:0033047)	3.49895810
76	regulation of sister chromatid segregation (GO:0033045)	3.49895810
77	dosage compensation (GO:0007549)	3.49891822
78	spindle assembly involved in mitosis (GO:0090307)	3.49584130
79	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.48778898
80	translesion synthesis (GO:0019985)	3.47830633
81	ATP-dependent chromatin remodeling (GO:0043044)	3.46940416
82	double-strand break repair via nonhomologous end joining (GO:0006303)	3.45611176
83	non-recombinational repair (GO:0000726)	3.45611176
84	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.43238271
85	chromatin assembly (GO:0031497)	3.41834065
86	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.40605229
87	telomere maintenance via telomere lengthening (GO:0010833)	3.40444807
88	ventricular cardiac muscle cell development (GO:0055015)	3.38049217
89	microtubule polymerization or depolymerization (GO:0031109)	3.37163237
90	microtubule depolymerization (GO:0007019)	3.34889678
91	folic acid-containing compound biosynthetic process (GO:0009396)	3.26958951
92	* DNA packaging (GO:0006323)	3.26451157
93	IMP biosynthetic process (GO:0006188)	3.25640275
94	protein K6-linked ubiquitination (GO:0085020)	3.23580446
95	negative regulation of cell division (GO:0051782)	3.22420322
96	regulation of centrosome duplication (GO:0010824)	3.22237610
97	spindle organization (GO:0007051)	3.20938879
98	postreplication repair (GO:0006301)	3.19747114
99	V(D)J recombination (GO:0033151)	3.19095180
100	negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)	3.18523000
101	regulation of RNA export from nucleus (GO:0046831)	3.18208921
102	mitotic nuclear division (GO:0007067)	3.17771550
103	nuclear envelope organization (GO:0006998)	3.17622942
104	mitotic G2 DNA damage checkpoint (GO:0007095)	3.16520642
105	* chromosome organization (GO:0051276)	3.13710017
106	heterochromatin organization (GO:0070828)	3.13186648
107	histone-serine phosphorylation (GO:0035404)	3.11441231
108	negative regulation of nuclear division (GO:0051784)	3.10638741
109	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	3.09860882
110	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.09066404
111	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.09066404
112	DNA synthesis involved in DNA repair (GO:0000731)	3.07625365
113	telomere maintenance (GO:0000723)	3.06518661
114	mismatch repair (GO:0006298)	3.05880753
115	regulation of helicase activity (GO:0051095)	3.05037580
116	* DNA topological change (GO:0006265)	3.04474338
117	telomere organization (GO:0032200)	3.03672033
118	pre-miRNA processing (GO:0031054)	3.02902083
119	protein complex localization (GO:0031503)	3.01446159
120	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.99192283
121	* mitotic cell cycle (GO:0000278)	2.98157495
122	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.96729922
123	nucleobase biosynthetic process (GO:0046112)	2.94543290

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* FOXM1_23109430_ChIP-Seq_U2OS_Human	7.27970585
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	5.07310728
3	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.18263632
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.28964188
5	* MYC_18555785_ChIP-Seq_MESCs_Mouse	3.23806015
6	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.06996781
7	AR_21909140_ChIP-Seq_LNCAP_Human	2.69195138
8	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.58038554
9	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.57660345
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.57656763
11	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.43560043
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.33361179
13	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.30306945
14	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.18216321
15	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.14165042
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06279439
17	E2F7_22180533_ChIP-Seq_HELA_Human	11.8494816
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91435089
19	XRN2_22483619_ChIP-Seq_HELA_Human	1.86418284
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85923477
21	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.85652158
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82444110
23	MYC_22102868_ChIP-Seq_BL_Human	1.81801863
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.75144819
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.72329534
26	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.67115163
27	CIITA_25753668_ChIP-Seq_RAJI_Human	1.61371086
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61142052
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.58210631
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.57577584
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56123745
32	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55545876
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54199448
34	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.51738958
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51071984
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50665230
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.49362417
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.48124504
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.47218527
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.44088891
41	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.42319088
42	* NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.37435202
43	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.34533485
44	KDM5A_27292631_Chip-Seq_BREAST_Human	1.34100292
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34097212
46	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.31777453
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31482389
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.29861717
49	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.27093217
50	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.26477323
51	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.25062544
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24499112
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.23926629
54	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23019778
55	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.20334168
56	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.16765196
57	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.15499109
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.13571566
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.12441003
60	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.11488906
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10949409
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.10179560
63	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09849955
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08241751
65	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.08208420
66	VDR_21846776_ChIP-Seq_THP-1_Human	1.07520287
67	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05586210
68	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.05372799
69	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04087909
70	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.03457914
71	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02086705
72	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.01959026
73	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.01449505
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00316837
75	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.99878579
76	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.98324407
77	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.98312258
78	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.97609735
79	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.96254417
80	TFEB_21752829_ChIP-Seq_HELA_Human	0.95678967
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92494734
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.91939526
83	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.90433947
84	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.89057206
85	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.85488500
86	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85116532
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.83308211
88	* SOX2_16153702_ChIP-ChIP_HESCs_Human	0.82864941
89	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.82575661
90	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.82504250
91	EWS_26573619_Chip-Seq_HEK293_Human	0.82232024
92	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.80554238
93	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.79634173
94	* POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.79149651
95	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.78629851
96	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.78058555
97	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.76803578
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.76227527
99	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.76040664
100	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.75428254
101	CHD1_26751641_Chip-Seq_LNCaP_Human	0.74257084
102	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.72059648
103	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.71288808
104	* NANOG_16153702_ChIP-ChIP_HESCs_Human	0.71276927
105	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.70637642
106	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.70305631
107	MYB_26560356_Chip-Seq_TH2_Human	0.67922188
108	MYB_26560356_Chip-Seq_TH1_Human	0.67820049
109	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.67701846
110	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.66619734
111	FUS_26573619_Chip-Seq_HEK293_Human	0.66478748
112	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.65851098
113	* SOX9_26525672_Chip-Seq_HEART_Mouse	0.62537721
114	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.60800129
115	ZNF263_19887448_ChIP-Seq_K562_Human	0.60691252
116	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.59979732

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.93281792
2	MP0003693_abnormal_embryo_hatching	4.49457898
3	MP0003111_abnormal_nucleus_morphology	4.39913986
4	MP0008057_abnormal_DNA_replication	3.94699465
5	MP0003077_abnormal_cell_cycle	3.92707397
6	MP0004957_abnormal_blastocyst_morpholog	3.71567736
7	MP0008058_abnormal_DNA_repair	2.70101665
8	MP0010307_abnormal_tumor_latency	2.69401732
9	MP0003123_paternal_imprinting	2.58013415
10	MP0008007_abnormal_cellular_replicative	2.54016049
11	MP0010352_gastrointestinal_tract_polyps	2.53648414
12	MP0008932_abnormal_embryonic_tissue	2.35595678
13	MP0009697_abnormal_copulation	2.34531117
14	MP0001730_embryonic_growth_arrest	2.31124916
15	MP0000350_abnormal_cell_proliferation	2.25908182
16	MP0008877_abnormal_DNA_methylation	2.21190538
17	MP0005076_abnormal_cell_differentiation	2.12523475
18	MP0002396_abnormal_hematopoietic_system	2.10736334
19	MP0003121_genomic_imprinting	2.06555970
20	MP0005380_embryogenesis_phenotype	1.85373420
21	MP0001672_abnormal_embryogenesis/_devel	1.85373420
22	MP0006292_abnormal_olfactory_placode	1.80918969
23	MP0003705_abnormal_hypodermis_morpholog	1.79358169
24	MP0001697_abnormal_embryo_size	1.78724251
25	MP0004197_abnormal_fetal_growth/weight/	1.76740708
26	MP0004808_abnormal_hematopoietic_stem	1.74899472
27	MP0002085_abnormal_embryonic_tissue	1.70073670
28	MP0002084_abnormal_developmental_patter	1.69523562
29	MP0003984_embryonic_growth_retardation	1.66899092
30	MP0002088_abnormal_embryonic_growth/wei	1.64444392
31	MP0003718_maternal_effect	1.64119827
32	MP0000566_synostosis	1.63495147
33	MP0002086_abnormal_extraembryonic_tissu	1.59587376
34	MP0002080_prenatal_lethality	1.55477180
35	MP0003567_abnormal_fetal_cardiomyocyte	1.51868510
36	MP0000537_abnormal_urethra_morphology	1.50625950
37	MP0010030_abnormal_orbit_morphology	1.47392585
38	MP0003890_abnormal_embryonic-extraembry	1.45782342
39	MP0000490_abnormal_crypts_of	1.44469182
40	MP0003786_premature_aging	1.42886376
41	MP0009053_abnormal_anal_canal	1.42599459
42	MP0006054_spinal_hemorrhage	1.35970185
43	MP0002019_abnormal_tumor_incidence	1.31092375
44	MP0000313_abnormal_cell_death	1.30856210
45	MP0001293_anophthalmia	1.28734655
46	MP0003937_abnormal_limbs/digits/tail_de	1.25517929
47	MP0001346_abnormal_lacrimal_gland	1.24478074
48	MP0000703_abnormal_thymus_morphology	1.17915656
49	MP0010234_abnormal_vibrissa_follicle	1.16600428
50	MP0009278_abnormal_bone_marrow	1.14804023
51	MP0000569_abnormal_digit_pigmentation	1.14757928
52	MP0003787_abnormal_imprinting	1.13403311
53	MP0003136_yellow_coat_color	1.12850392
54	MP0009703_decreased_birth_body	1.09167777
55	MP0002210_abnormal_sex_determination	1.06733111
56	MP0009672_abnormal_birth_weight	1.05666982
57	MP0002233_abnormal_nose_morphology	1.05649384
58	MP0003315_abnormal_perineum_morphology	1.04129522
59	MP0000733_abnormal_muscle_development	0.96106324
60	MP0003566_abnormal_cell_adhesion	0.95156359
61	MP0001145_abnormal_male_reproductive	0.93618890
62	MP0002092_abnormal_eye_morphology	0.92836771
63	MP0002398_abnormal_bone_marrow	0.92012646
64	MP0001545_abnormal_hematopoietic_system	0.91671124
65	MP0005397_hematopoietic_system_phenotyp	0.91671124
66	MP0002111_abnormal_tail_morphology	0.91520003
67	MP0000428_abnormal_craniofacial_morphol	0.88932096
68	MP0001915_intracranial_hemorrhage	0.87715677
69	MP0003935_abnormal_craniofacial_develop	0.86365986
70	MP0005623_abnormal_meninges_morphology	0.86144297
71	MP0003115_abnormal_respiratory_system	0.86054397
72	MP0002697_abnormal_eye_size	0.85818567
73	MP0001299_abnormal_eye_distance/	0.85781260
74	MP0002722_abnormal_immune_system	0.85452525
75	MP0001849_ear_inflammation	0.84641759
76	MP0000432_abnormal_head_morphology	0.83492782
77	MP0003119_abnormal_digestive_system	0.82749117
78	MP0005023_abnormal_wound_healing	0.82732783
79	MP0001286_abnormal_eye_development	0.82690451
80	MP0001929_abnormal_gametogenesis	0.81318887
81	MP0002234_abnormal_pharynx_morphology	0.81280521
82	MP0003763_abnormal_thymus_physiology	0.80440597
83	MP0005171_absent_coat_pigmentation	0.80189377
84	MP0000579_abnormal_nail_morphology	0.77593243
85	MP0002925_abnormal_cardiovascular_devel	0.77564752
86	MP0000653_abnormal_sex_gland	0.77342204
87	MP0003942_abnormal_urinary_system	0.77176457
88	MP0000689_abnormal_spleen_morphology	0.74885855
89	MP0002009_preneoplasia	0.74629725
90	MP0000049_abnormal_middle_ear	0.74535188
91	MP0005248_abnormal_Harderian_gland	0.74314760
92	MP0010678_abnormal_skin_adnexa	0.73435924
93	MP0000358_abnormal_cell_content/	0.73404802
94	MP0000647_abnormal_sebaceous_gland	0.73181271
95	MP0003941_abnormal_skin_development	0.72395192
96	MP0000383_abnormal_hair_follicle	0.71934160
97	MP0004233_abnormal_muscle_weight	0.71881104
98	MP0005621_abnormal_cell_physiology	0.71488793
99	MP0005408_hypopigmentation	0.71397682
100	MP0005384_cellular_phenotype	0.70170649
101	MP0005391_vision/eye_phenotype	0.69756556
102	MP0004185_abnormal_adipocyte_glucose	0.69263990
103	MP0001529_abnormal_vocalization	0.69099845
104	MP0002938_white_spotting	0.68902813
105	MP0001119_abnormal_female_reproductive	0.68134174
106	MP0003755_abnormal_palate_morphology	0.67506531
107	MP0002166_altered_tumor_susceptibility	0.67155670
108	MP0002006_tumorigenesis	0.67054490
109	MP0004264_abnormal_extraembryonic_tissu	0.66999795
110	MP0003699_abnormal_female_reproductive	0.65933933
111	MP0003861_abnormal_nervous_system	0.65750899
112	MP0002081_perinatal_lethality	0.65506215
113	MP0000762_abnormal_tongue_morphology	0.65092439
114	MP0002095_abnormal_skin_pigmentation	0.64281643
115	MP0003385_abnormal_body_wall	0.63996747
116	MP0002075_abnormal_coat/hair_pigmentati	0.63689506
117	MP0002877_abnormal_melanocyte_morpholog	0.63315630
118	MP0002932_abnormal_joint_morphology	0.62975471
119	MP0003950_abnormal_plasma_membrane	0.62602915
120	MP0008789_abnormal_olfactory_epithelium	0.62247646
121	MP0001661_extended_life_span	0.61788496
122	MP0002429_abnormal_blood_cell	0.61612416
123	MP0000477_abnormal_intestine_morphology	0.61412502
124	MP0002116_abnormal_craniofacial_bone	0.61001700
125	MP0005187_abnormal_penis_morphology	0.60735818
126	MP0002161_abnormal_fertility/fecundity	0.60698286
127	MP0002282_abnormal_trachea_morphology	0.59293523
128	MP0009333_abnormal_splenocyte_physiolog	0.58187400
129	MP0002114_abnormal_axial_skeleton	0.57889290
130	MP0003943_abnormal_hepatobiliary_system	0.57544174

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	4.41767324
2	Cortical dysplasia (HP:0002539)	4.17572604
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.08198637
4	Volvulus (HP:0002580)	3.99284591
5	Abnormality of chromosome stability (HP:0003220)	3.61203764
6	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.46994865
7	Short 4th metacarpal (HP:0010044)	3.46994865
8	Increased nuchal translucency (HP:0010880)	3.44255014
9	Ependymoma (HP:0002888)	3.29740297
10	Medulloblastoma (HP:0002885)	3.25718508
11	Colon cancer (HP:0003003)	3.21437956
12	Reticulocytopenia (HP:0001896)	3.05713583
13	Selective tooth agenesis (HP:0001592)	3.03212791
14	Impulsivity (HP:0100710)	2.98055835
15	Meckel diverticulum (HP:0002245)	2.97839616
16	Ectopic kidney (HP:0000086)	2.92221424
17	Proximal placement of thumb (HP:0009623)	2.86013637
18	Deviation of the thumb (HP:0009603)	2.83194147
19	Abnormality of the ileum (HP:0001549)	2.83109462
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.81384719
21	Small intestinal stenosis (HP:0012848)	2.79543459
22	Duodenal stenosis (HP:0100867)	2.79543459
23	Abnormality of the preputium (HP:0100587)	2.75722547
24	Birth length less than 3rd percentile (HP:0003561)	2.68977432
25	Rhabdomyosarcoma (HP:0002859)	2.68846697
26	Patellar aplasia (HP:0006443)	2.67075692
27	Abnormal lung lobation (HP:0002101)	2.65100700
28	Myelodysplasia (HP:0002863)	2.62117175
29	Agnosia (HP:0010524)	2.58530203
30	Nephroblastoma (Wilms tumor) (HP:0002667)	2.54284476
31	Embryonal neoplasm (HP:0002898)	2.53791491
32	Astrocytoma (HP:0009592)	2.52466153
33	Abnormality of the astrocytes (HP:0100707)	2.52466153
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.50417225
35	Abnormality of the labia minora (HP:0012880)	2.49009708
36	Aplasia/Hypoplasia of the patella (HP:0006498)	2.48926636
37	Abnormal number of incisors (HP:0011064)	2.47631084
38	Abnormality of the 4th metacarpal (HP:0010012)	2.46368145
39	High pitched voice (HP:0001620)	2.41612255
40	Embryonal renal neoplasm (HP:0011794)	2.37983041
41	Sloping forehead (HP:0000340)	2.36158898
42	Cafe-au-lait spot (HP:0000957)	2.35972614
43	Abnormality of the duodenum (HP:0002246)	2.34992813
44	11 pairs of ribs (HP:0000878)	2.34231687
45	Abnormality of the carotid arteries (HP:0005344)	2.32865510
46	Duplication of thumb phalanx (HP:0009942)	2.30330853
47	Absent radius (HP:0003974)	2.30288016
48	Overlapping toe (HP:0001845)	2.29845823
49	Facial hemangioma (HP:0000329)	2.28911093
50	Glioma (HP:0009733)	2.25074332
51	High anterior hairline (HP:0009890)	2.24132971
52	Basal cell carcinoma (HP:0002671)	2.23659379
53	Atresia of the external auditory canal (HP:0000413)	2.21500282
54	Biliary tract neoplasm (HP:0100574)	2.19560404
55	Prominent nose (HP:0000448)	2.18169247
56	Neoplasm of the oral cavity (HP:0100649)	2.15684428
57	Choanal atresia (HP:0000453)	2.13116425
58	Absent forearm bone (HP:0003953)	2.13064600
59	Aplasia involving forearm bones (HP:0009822)	2.13064600
60	Deep philtrum (HP:0002002)	2.12616360
61	Neoplasm of striated muscle (HP:0009728)	2.11247566
62	Missing ribs (HP:0000921)	2.11011280
63	Absent thumb (HP:0009777)	2.08180816
64	Abnormality of the fingertips (HP:0001211)	2.07928196
65	Duplicated collecting system (HP:0000081)	2.06748395
66	Gastrointestinal carcinoma (HP:0002672)	2.02073513
67	Malignant gastrointestinal tract tumors (HP:0006749)	2.02073513
68	Neoplasm of the pancreas (HP:0002894)	2.01565196
69	Abnormality of chromosome segregation (HP:0002916)	2.01368232
70	Renal duplication (HP:0000075)	1.99596764
71	Ovarian neoplasm (HP:0100615)	1.98290843
72	Long eyelashes (HP:0000527)	1.97353943
73	Skull defect (HP:0001362)	1.97133693
74	Short thumb (HP:0009778)	1.97059060
75	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.95369483
76	Hypoplastic pelvis (HP:0008839)	1.93834506
77	Cutis marmorata (HP:0000965)	1.93229229
78	Sandal gap (HP:0001852)	1.90991979
79	Supernumerary spleens (HP:0009799)	1.90453418
80	Neoplasm of the colon (HP:0100273)	1.89815047
81	Abnormality of the renal collecting system (HP:0004742)	1.88627129
82	Breast hypoplasia (HP:0003187)	1.88507767
83	Bone marrow hypocellularity (HP:0005528)	1.87910662
84	Abnormality of the anterior horn cell (HP:0006802)	1.87684446
85	Degeneration of anterior horn cells (HP:0002398)	1.87684446
86	Tracheoesophageal fistula (HP:0002575)	1.87670156
87	Abnormality of the calcaneus (HP:0008364)	1.85484240
88	Broad distal phalanx of finger (HP:0009836)	1.84699486
89	Amaurosis fugax (HP:0100576)	1.84479295
90	Squamous cell carcinoma (HP:0002860)	1.81886643
91	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.81573874
92	Absent epiphyses (HP:0010577)	1.81573874
93	Truncal obesity (HP:0001956)	1.81561027
94	Irregular epiphyses (HP:0010582)	1.81411530
95	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.80581338
96	Clubbing of toes (HP:0100760)	1.79313203
97	Cutaneous melanoma (HP:0012056)	1.78148003
98	Broad palm (HP:0001169)	1.76961828
99	Abnormality of cochlea (HP:0000375)	1.76641913
100	Heterotopia (HP:0002282)	1.76121639
101	Hyperacusis (HP:0010780)	1.72898469
102	Small epiphyses (HP:0010585)	1.72788015
103	Oral leukoplakia (HP:0002745)	1.72125606
104	Intestinal polyp (HP:0005266)	1.71331712
105	Intestinal polyposis (HP:0200008)	1.70976050
106	Horseshoe kidney (HP:0000085)	1.70507863
107	Leiomyosarcoma (HP:0100243)	1.69441988
108	Uterine leiomyosarcoma (HP:0002891)	1.69441988
109	Abnormality of DNA repair (HP:0003254)	1.67596119
110	Arteriovenous malformation (HP:0100026)	1.66568213
111	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.65272478
112	Obsessive-compulsive behavior (HP:0000722)	1.65252166
113	Abnormality of abdominal situs (HP:0011620)	1.63842812
114	Abdominal situs inversus (HP:0003363)	1.63842812
115	Microtia (HP:0008551)	1.62922451
116	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.62684483
117	Abnormality of the septum pellucidum (HP:0007375)	1.62430906
118	Long clavicles (HP:0000890)	1.62423369
119	Triphalangeal thumb (HP:0001199)	1.62284001
120	Abnormal foot bone ossification (HP:0010675)	1.62078869
121	Hypopigmentation of the fundus (HP:0007894)	1.59719794
122	Multiple enchondromatosis (HP:0005701)	1.55534893
123	Flared metaphyses (HP:0003015)	1.55056662
124	Limited elbow extension (HP:0001377)	1.54730837
125	Vertebral arch anomaly (HP:0008438)	1.54579498
126	Abnormality of the fetal cardiovascular system (HP:0010948)	1.54503737
127	Abnormal umbilical cord blood vessels (HP:0011403)	1.54503737
128	Single umbilical artery (HP:0001195)	1.54503737
129	Progressive external ophthalmoplegia (HP:0000590)	1.54260187
130	Oligodactyly (hands) (HP:0001180)	1.51658413
131	Septo-optic dysplasia (HP:0100842)	1.51512872
132	Facial cleft (HP:0002006)	1.51031505
133	Carpal bone hypoplasia (HP:0001498)	1.51004474
134	Abnormality of the phalanges of the hallux (HP:0010057)	1.50614454
135	Oligodactyly (HP:0012165)	1.50065668

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	5.27732373
2	WEE1	3.72579470
3	NEK2	3.65780838
4	BUB1	3.61353842
5	CDK12	2.83447223
6	TTK	2.75208231
7	NEK1	2.70167177
8	SRPK1	2.35947284
9	EEF2K	2.24134959
10	BRSK2	2.20844531
11	TLK1	2.16578214
12	AURKB	2.08834229
13	PASK	1.97144155
14	* PLK1	1.96417441
15	MKNK1	1.95781997
16	ATR	1.94238667
17	STK4	1.85110896
18	MAP3K10	1.78990853
19	ACVR1B	1.71102144
20	CDK4	1.66057912
21	RPS6KB2	1.65268557
22	STK10	1.64862225
23	PLK4	1.63928012
24	CHEK2	1.63060055
25	EIF2AK1	1.61297038
26	CCNB1	1.54324886
27	MAP3K8	1.53717367
28	TSSK6	1.53234800
29	PKN2	1.51539373
30	BRSK1	1.51208157
31	CHEK1	1.47679399
32	BRD4	1.46846587
33	CDK7	1.44346620
34	CDK6	1.41795145
35	TAF1	1.35798244
36	ZAK	1.33960625
37	MKNK2	1.32791501
38	BRAF	1.31772860
39	SCYL2	1.31595922
40	MELK	1.27658965
41	* PLK3	1.25717583
42	VRK1	1.24576470
43	ATM	1.21400094
44	RPS6KA4	1.19615242
45	TGFBR1	1.18757947
46	VRK2	1.18183977
47	STK3	1.14802026
48	CLK1	1.14695229
49	DYRK3	1.06351664
50	AURKA	1.04002804
51	CDK2	1.01359259
52	SMG1	0.90349163
53	PIM1	0.89202010
54	PAK4	0.87143646
55	* CDK1	0.87089156
56	LATS1	0.83799004
57	TESK2	0.81875286
58	TTN	0.81628316
59	ALK	0.75918647
60	MST1R	0.73735784
61	FLT3	0.72658191
62	CDK9	0.72482547
63	LATS2	0.72446391
64	EIF2AK3	0.66199243
65	LRRK2	0.64260241
66	MTOR	0.62831908
67	ERBB4	0.61049966
68	MET	0.60605838
69	RPS6KA5	0.60285811
70	EPHA2	0.55696664
71	CDK18	0.55387247
72	CDK15	0.55081790
73	TRIM28	0.54938795
74	PRKDC	0.52862774
75	CSNK1D	0.51823176
76	CDK11A	0.51795298
77	MAP4K1	0.51328111
78	EIF2AK2	0.47548943
79	CDK3	0.46830198
80	FGFR1	0.46770852
81	PNCK	0.46131495
82	PTK6	0.45423828
83	CDK14	0.44815473
84	MAPK14	0.44319444
85	* CSNK2A2	0.43680025
86	BCR	0.43673926
87	ICK	0.42320138
88	YES1	0.42189438
89	TRIB3	0.41338468
90	AKT2	0.40585888
91	MARK3	0.40152310
92	ERBB3	0.38810535
93	* CSNK2A1	0.38641777
94	DYRK1B	0.38531011
95	PAK1	0.38385739
96	PBK	0.38079201
97	STK38L	0.36233478
98	AKT1	0.35529188
99	PLK2	0.35186376
100	PAK2	0.34075982
101	CAMK1G	0.33929076
102	GRK6	0.33233553
103	KSR1	0.31498198
104	CSNK1E	0.31195307
105	BTK	0.30895895
106	NEK9	0.29759287
107	NUAK1	0.29060303
108	PDGFRA	0.28782174
109	CSF1R	0.28554814
110	STK16	0.25972089
111	UHMK1	0.25901764
112	* GSK3B	0.25528932
113	CAMK1D	0.24552481
114	* MAPK1	0.23810864
115	TRPM7	0.23641216
116	RPS6KB1	0.23621680
117	TEC	0.23598664
118	NME2	0.23531270
119	MST4	0.23223430
120	RAF1	0.22119514
121	CDK8	0.22051900
122	CHUK	0.21711104
123	RPS6KC1	0.20972914
124	DMPK	0.19519080
125	PRKCI	0.18918239
126	FGFR2	0.18631274
127	TNIK	0.17239437
128	MINK1	0.16586723

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.99729476
2	Mismatch repair_Homo sapiens_hsa03430	4.44665156
3	Cell cycle_Homo sapiens_hsa04110	3.49128660
4	Homologous recombination_Homo sapiens_hsa03440	3.14995636
5	Base excision repair_Homo sapiens_hsa03410	3.14394041
6	Spliceosome_Homo sapiens_hsa03040	3.09999815
7	RNA transport_Homo sapiens_hsa03013	2.99326152
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.83409404
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.77720341
10	One carbon pool by folate_Homo sapiens_hsa00670	2.72806294
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.71192507
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.68810159
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.62730753
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.21827731
15	mRNA surveillance pathway_Homo sapiens_hsa03015	2.11307422
16	p53 signaling pathway_Homo sapiens_hsa04115	1.83476691
17	RNA degradation_Homo sapiens_hsa03018	1.78797917
18	Ribosome_Homo sapiens_hsa03010	1.67554651
19	Viral carcinogenesis_Homo sapiens_hsa05203	1.66583973
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58037050
21	RNA polymerase_Homo sapiens_hsa03020	1.49697356
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.43265837
23	Alcoholism_Homo sapiens_hsa05034	1.39490943
24	Basal transcription factors_Homo sapiens_hsa03022	1.37125202
25	Oocyte meiosis_Homo sapiens_hsa04114	1.37046130
26	MicroRNAs in cancer_Homo sapiens_hsa05206	1.35964240
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.33504046
28	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.24972423
29	HTLV-I infection_Homo sapiens_hsa05166	1.15808203
30	Proteasome_Homo sapiens_hsa03050	1.13426529
31	Small cell lung cancer_Homo sapiens_hsa05222	1.12340966
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.12201212
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.12094670
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11396635
35	Herpes simplex infection_Homo sapiens_hsa05168	1.09505577
36	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.06491159
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.05768546
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01608252
39	Steroid biosynthesis_Homo sapiens_hsa00100	0.97781003
40	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.92693076
41	Carbon metabolism_Homo sapiens_hsa01200	0.90876056
42	Colorectal cancer_Homo sapiens_hsa05210	0.90362709
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82848615
44	Protein export_Homo sapiens_hsa03060	0.81443870
45	Basal cell carcinoma_Homo sapiens_hsa05217	0.81305099
46	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.78193023
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.78176860
48	Thyroid cancer_Homo sapiens_hsa05216	0.77270655
49	Folate biosynthesis_Homo sapiens_hsa00790	0.76407059
50	Lysine degradation_Homo sapiens_hsa00310	0.76052773
51	Adherens junction_Homo sapiens_hsa04520	0.74759885
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.73828013
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.72883669
54	Hepatitis B_Homo sapiens_hsa05161	0.70831750
55	Purine metabolism_Homo sapiens_hsa00230	0.70516896
56	Viral myocarditis_Homo sapiens_hsa05416	0.69735651
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69245081
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.68951746
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.68231308
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67912076
61	Prostate cancer_Homo sapiens_hsa05215	0.64296747
62	Propanoate metabolism_Homo sapiens_hsa00640	0.64177929
63	Notch signaling pathway_Homo sapiens_hsa04330	0.63576625
64	Apoptosis_Homo sapiens_hsa04210	0.61291112
65	Non-small cell lung cancer_Homo sapiens_hsa05223	0.61149197
66	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.58404638
67	Pancreatic cancer_Homo sapiens_hsa05212	0.58006057
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57420663
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57268079
70	Legionellosis_Homo sapiens_hsa05134	0.54059863
71	Pathways in cancer_Homo sapiens_hsa05200	0.53531272
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53352043
73	mTOR signaling pathway_Homo sapiens_hsa04150	0.53286579
74	Measles_Homo sapiens_hsa05162	0.52416964
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50933616
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49965912
77	Proteoglycans in cancer_Homo sapiens_hsa05205	0.49952404
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49159091
79	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.48987107
80	Bladder cancer_Homo sapiens_hsa05219	0.48489974
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46133627
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.45673931
83	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.45582307
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42756710
85	Endometrial cancer_Homo sapiens_hsa05213	0.42219930
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41788418
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40597078
88	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.40191877
89	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.39471588
90	Fatty acid elongation_Homo sapiens_hsa00062	0.39462134
91	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.39461645
92	Influenza A_Homo sapiens_hsa05164	0.39062773
93	Glutathione metabolism_Homo sapiens_hsa00480	0.39052491
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38907536
95	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.38126170
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.36584960
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.36058404
98	Shigellosis_Homo sapiens_hsa05131	0.35724501
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35129769
100	Melanoma_Homo sapiens_hsa05218	0.33660142
101	Wnt signaling pathway_Homo sapiens_hsa04310	0.33075921
102	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.32746494
103	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32260746
104	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30492004
105	Fatty acid metabolism_Homo sapiens_hsa01212	0.30428504
106	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30396200
107	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30007779
108	Huntingtons disease_Homo sapiens_hsa05016	0.28780119
109	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.28564712
110	Tight junction_Homo sapiens_hsa04530	0.28102610
111	Focal adhesion_Homo sapiens_hsa04510	0.26158765
112	Glioma_Homo sapiens_hsa05214	0.24979056
113	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.24629856
114	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.24079893
115	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23781656
116	Toxoplasmosis_Homo sapiens_hsa05145	0.23057795
117	Gap junction_Homo sapiens_hsa04540	0.22477190
118	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21604903
119	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21092340
120	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.20960605
121	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.19891567
122	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.19497902
123	Leishmaniasis_Homo sapiens_hsa05140	0.19011868
124	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.18803400
125	Melanogenesis_Homo sapiens_hsa04916	0.18384102
126	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.18238038
127	Platelet activation_Homo sapiens_hsa04611	0.18123298
128	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.17838568
129	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17377822
130	Sulfur relay system_Homo sapiens_hsa04122	0.15483745
131	Metabolic pathways_Homo sapiens_hsa01100	0.14780598
132	AMPK signaling pathway_Homo sapiens_hsa04152	0.14682872
133	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.12776284

TOP2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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