TOP3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.91908171
2protein localization to kinetochore (GO:0034501)4.75058808
3nuclear pore organization (GO:0006999)4.73660198
4folic acid-containing compound biosynthetic process (GO:0009396)4.41682877
5prenylation (GO:0097354)4.38496521
6protein prenylation (GO:0018342)4.38496521
7negative regulation of histone methylation (GO:0031061)4.37632358
8IMP biosynthetic process (GO:0006188)4.30396301
9DNA unwinding involved in DNA replication (GO:0006268)4.19877884
10mitotic nuclear envelope disassembly (GO:0007077)4.13682620
11DNA strand elongation involved in DNA replication (GO:0006271)4.11825706
12spliceosomal tri-snRNP complex assembly (GO:0000244)4.11597495
13protein localization to chromosome, centromeric region (GO:0071459)4.10755322
14DNA strand elongation (GO:0022616)4.05386156
15pore complex assembly (GO:0046931)4.04548428
16telomere maintenance via semi-conservative replication (GO:0032201)3.95156544
17DNA replication initiation (GO:0006270)3.94994627
18nuclear envelope disassembly (GO:0051081)3.85492314
19membrane disassembly (GO:0030397)3.85492314
20regulation of histone H3-K9 methylation (GO:0051570)3.81514837
21DNA replication checkpoint (GO:0000076)3.76683583
22ribosomal small subunit assembly (GO:0000028)3.76113310
23regulation of DNA endoreduplication (GO:0032875)3.75601304
24IMP metabolic process (GO:0046040)3.69984892
25regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.64117078
26chromosome condensation (GO:0030261)3.57100784
27telomere maintenance via recombination (GO:0000722)3.53247771
28DNA replication-dependent nucleosome assembly (GO:0006335)3.51581886
29DNA replication-dependent nucleosome organization (GO:0034723)3.51581886
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45307983
31mitotic sister chromatid segregation (GO:0000070)3.43493492
32regulation of histone H3-K27 methylation (GO:0061085)3.43414450
33regulation of RNA export from nucleus (GO:0046831)3.40180626
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39754924
35regulation of translational fidelity (GO:0006450)3.39697412
36DNA duplex unwinding (GO:0032508)3.39419194
37histone H2A monoubiquitination (GO:0035518)3.37325244
38DNA synthesis involved in DNA repair (GO:0000731)3.36991729
39mitotic recombination (GO:0006312)3.35870760
40DNA geometric change (GO:0032392)3.35757842
41regulation of sister chromatid cohesion (GO:0007063)3.32202459
42nucleobase biosynthetic process (GO:0046112)3.26318890
43mitotic metaphase plate congression (GO:0007080)3.26098873
44non-recombinational repair (GO:0000726)3.21413842
45double-strand break repair via nonhomologous end joining (GO:0006303)3.21413842
46formation of translation preinitiation complex (GO:0001731)3.19421169
47DNA replication-independent nucleosome organization (GO:0034724)3.18742546
48DNA replication-independent nucleosome assembly (GO:0006336)3.18742546
49mitotic sister chromatid cohesion (GO:0007064)3.18632423
50DNA packaging (GO:0006323)3.18547490
51sister chromatid segregation (GO:0000819)3.16257016
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.14831981
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14831981
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14831981
55folic acid metabolic process (GO:0046655)3.13027515
56telomere maintenance via telomere lengthening (GO:0010833)3.12479737
57intra-S DNA damage checkpoint (GO:0031573)3.10004878
58dosage compensation (GO:0007549)3.07626944
59regulation of DNA damage checkpoint (GO:2000001)3.05575854
60kinetochore organization (GO:0051383)3.04288596
61negative regulation of mRNA processing (GO:0050686)3.04160524
62viral mRNA export from host cell nucleus (GO:0046784)3.03630581
63snRNA metabolic process (GO:0016073)3.03442905
64chromatin remodeling at centromere (GO:0031055)3.03291162
65negative regulation of mRNA metabolic process (GO:1903312)3.03125671
66maturation of SSU-rRNA (GO:0030490)3.02655546
67chromosome segregation (GO:0007059)3.01935452
68attachment of spindle microtubules to kinetochore (GO:0008608)3.01629693
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97559400
70heterochromatin organization (GO:0070828)2.96234250
71nucleotide-excision repair, DNA gap filling (GO:0006297)2.96007650
72histone H2A acetylation (GO:0043968)2.95264266
73metaphase plate congression (GO:0051310)2.94643662
74chromatin assembly or disassembly (GO:0006333)2.92996196
75* DNA topological change (GO:0006265)2.92139730
76purine nucleobase biosynthetic process (GO:0009113)2.92135626
77mitochondrial DNA metabolic process (GO:0032042)2.92105150
78sister chromatid cohesion (GO:0007062)2.91738236
79CENP-A containing nucleosome assembly (GO:0034080)2.91232241
80translesion synthesis (GO:0019985)2.90149906
81nuclear envelope organization (GO:0006998)2.89993302
82mitotic chromosome condensation (GO:0007076)2.87625922
83ribosomal small subunit biogenesis (GO:0042274)2.85755896
84* DNA conformation change (GO:0071103)2.85038467
85V(D)J recombination (GO:0033151)2.84476142
86regulation of chromosome segregation (GO:0051983)2.84019841
87snRNA processing (GO:0016180)2.81676085
88regulation of centriole replication (GO:0046599)2.81382874
89positive regulation of cell cycle checkpoint (GO:1901978)2.80592824
90ATP-dependent chromatin remodeling (GO:0043044)2.80547408
91telomere maintenance (GO:0000723)2.80472038
92regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79679002
93DNA ligation (GO:0006266)2.78621193
94rRNA processing (GO:0006364)2.78175082
95telomere organization (GO:0032200)2.78169224
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.77332086
97establishment of chromosome localization (GO:0051303)2.75311636
98tetrahydrofolate metabolic process (GO:0046653)2.73869615
99pre-miRNA processing (GO:0031054)2.73523632
100regulation of chromatin binding (GO:0035561)2.72248208
101maturation of 5.8S rRNA (GO:0000460)2.71561204
102ribosome biogenesis (GO:0042254)2.70521838
103rRNA metabolic process (GO:0016072)2.70482648
104spindle organization (GO:0007051)2.70334114
105peptidyl-lysine dimethylation (GO:0018027)2.70111558
106histone mRNA catabolic process (GO:0071044)2.69629961
107regulation of nucleobase-containing compound transport (GO:0032239)2.69434542
108histone phosphorylation (GO:0016572)2.69234251
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68823726
110rRNA transcription (GO:0009303)2.68805393
111monoubiquitinated protein deubiquitination (GO:0035520)2.67806230
112ribonucleoprotein complex biogenesis (GO:0022613)2.67735257
113mRNA transport (GO:0051028)2.67276734
114regulation of spindle organization (GO:0090224)2.67191747
115positive regulation of hormone biosynthetic process (GO:0046886)2.66166737
116DNA replication (GO:0006260)2.65872335
117kinetochore assembly (GO:0051382)2.65133557
118chromatin assembly (GO:0031497)2.62788226
119regulation of DNA-dependent DNA replication (GO:0090329)2.62531903
120negative regulation of cell cycle G2/M phase transition (GO:1902750)2.62068334
121DNA-dependent DNA replication (GO:0006261)2.61215128
122regulation of centrosome cycle (GO:0046605)2.61144552
123spindle assembly (GO:0051225)2.60538579
124histone H3-K9 methylation (GO:0051567)2.60161754
125positive regulation of chromosome segregation (GO:0051984)2.59433418
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.59315045
127RNA stabilization (GO:0043489)2.57535467
128mitochondrial DNA replication (GO:0006264)2.57483019
129histone exchange (GO:0043486)2.56927386
130viral transcription (GO:0019083)2.56465937
131NIK/NF-kappaB signaling (GO:0038061)2.56380900
132base-excision repair (GO:0006284)2.56273105
133nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56195027
134ribosomal large subunit biogenesis (GO:0042273)2.55092271
135mRNA transcription from RNA polymerase II promoter (GO:0042789)2.52974794
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.52600228
137meiotic chromosome segregation (GO:0045132)2.52136231
138negative regulation of chromosome segregation (GO:0051985)2.52069386
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.50832179
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50832179
141positive regulation of histone methylation (GO:0031062)2.50637440
142translational termination (GO:0006415)2.49824421
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49569166
144regulation of mitotic spindle checkpoint (GO:1903504)2.49569166
145pteridine-containing compound biosynthetic process (GO:0042559)2.49461247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.08171036
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86787401
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48992403
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.43720290
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99453579
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79926005
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.72267566
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52842069
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40988132
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28532322
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21132714
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16492517
13MYC_22102868_ChIP-Seq_BL_Human2.11495464
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.06992164
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98930612
16* E2F1_21310950_ChIP-Seq_MCF-7_Human1.98371862
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.88210300
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86916023
19XRN2_22483619_ChIP-Seq_HELA_Human1.85536796
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83377436
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81130440
22VDR_23849224_ChIP-Seq_CD4+_Human1.81086760
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75862172
24AR_21909140_ChIP-Seq_LNCAP_Human1.71684821
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65857376
26FOXP3_21729870_ChIP-Seq_TREG_Human1.65723210
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63003231
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62487781
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60805095
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57840914
31DCP1A_22483619_ChIP-Seq_HELA_Human1.57378070
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55659877
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55217694
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.54499128
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54277051
36VDR_21846776_ChIP-Seq_THP-1_Human1.53082587
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52218887
38* GABP_17652178_ChIP-ChIP_JURKAT_Human1.50801742
39KDM5A_27292631_Chip-Seq_BREAST_Human1.50615011
40CIITA_25753668_ChIP-Seq_RAJI_Human1.49470537
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46723842
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45368762
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45051907
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43197570
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41566768
46* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39836876
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38493157
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.36855399
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35597716
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34799554
51TTF2_22483619_ChIP-Seq_HELA_Human1.33098417
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32679750
53* GABP_19822575_ChIP-Seq_HepG2_Human1.32446305
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.31841820
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31397739
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31194622
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28811718
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28294186
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27681601
60ELK1_19687146_ChIP-ChIP_HELA_Human1.24079002
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23811636
62* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23422921
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22702623
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22439487
65SPI1_23547873_ChIP-Seq_NB4_Human1.22050312
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21445531
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21044823
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19093306
69MAF_26560356_Chip-Seq_TH2_Human1.18979348
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17476228
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16717874
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16228401
73TFEB_21752829_ChIP-Seq_HELA_Human1.14162685
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13447350
75MYB_26560356_Chip-Seq_TH1_Human1.12967382
76MAF_26560356_Chip-Seq_TH1_Human1.12698997
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.12093470
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10961769
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.09005354
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08682307
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.07960610
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07674298
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07473964
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.06799592
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05308651
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.02895552
87* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02754829
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02289289
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01024211
90MYB_26560356_Chip-Seq_TH2_Human1.00349112
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98833918
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98138493
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98026726
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96993691
95CHD1_26751641_Chip-Seq_LNCaP_Human0.96414631
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95643277
97KDM2B_26808549_Chip-Seq_DND41_Human0.95313682
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94595608
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94107901
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93843909
101UTX_26944678_Chip-Seq_JUKART_Human0.93519384
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93266394
103TCF7_22412390_ChIP-Seq_EML_Mouse0.92892313
104NCOR1_26117541_ChIP-Seq_K562_Human0.92407181
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92105429
106* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90714164
107* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90446750
108* SRF_21415370_ChIP-Seq_HL-1_Mouse0.90181560
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.89859284
110VDR_24763502_ChIP-Seq_THP-1_Human0.87958205
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87850626
112* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87685411
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.87143266
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87043461
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85862621
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85455280
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84885635
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83880883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.85267931
2MP0003111_abnormal_nucleus_morphology3.55344091
3MP0003693_abnormal_embryo_hatching3.36321126
4MP0008057_abnormal_DNA_replication3.35464223
5MP0003077_abnormal_cell_cycle3.02521508
6MP0004957_abnormal_blastocyst_morpholog2.84062056
7MP0002396_abnormal_hematopoietic_system2.76924270
8MP0010352_gastrointestinal_tract_polyps2.31963829
9MP0008058_abnormal_DNA_repair2.11768688
10MP0008007_abnormal_cellular_replicative2.10341739
11MP0003123_paternal_imprinting1.99724025
12MP0004233_abnormal_muscle_weight1.97102754
13MP0008877_abnormal_DNA_methylation1.96949969
14MP0005451_abnormal_body_composition1.87958352
15MP0001730_embryonic_growth_arrest1.87116782
16MP0010307_abnormal_tumor_latency1.82537587
17MP0002009_preneoplasia1.81824852
18MP0000350_abnormal_cell_proliferation1.79942604
19MP0004808_abnormal_hematopoietic_stem1.76986395
20MP0001835_abnormal_antigen_presentation1.70258880
21MP0009278_abnormal_bone_marrow1.67642742
22MP0005387_immune_system_phenotype1.63935035
23MP0001790_abnormal_immune_system1.63935035
24MP0008260_abnormal_autophagy1.63896848
25MP0005075_abnormal_melanosome_morpholog1.62127160
26MP0005076_abnormal_cell_differentiation1.61520333
27MP0001545_abnormal_hematopoietic_system1.61347009
28MP0005397_hematopoietic_system_phenotyp1.61347009
29MP0005380_embryogenesis_phenotype1.49458902
30MP0001672_abnormal_embryogenesis/_devel1.49458902
31MP0000490_abnormal_crypts_of1.48999206
32MP0002398_abnormal_bone_marrow1.48785076
33MP0003984_embryonic_growth_retardation1.43445614
34MP0002088_abnormal_embryonic_growth/wei1.40192959
35MP0001800_abnormal_humoral_immune1.39216622
36* MP0008932_abnormal_embryonic_tissue1.38331760
37MP0003453_abnormal_keratinocyte_physiol1.38126140
38MP0003786_premature_aging1.37483023
39MP0001346_abnormal_lacrimal_gland1.37400300
40MP0000685_abnormal_immune_system1.33364050
41MP0002722_abnormal_immune_system1.33302439
42MP0003763_abnormal_thymus_physiology1.31881992
43MP0005671_abnormal_response_to1.31749623
44MP0004185_abnormal_adipocyte_glucose1.29487083
45MP0002019_abnormal_tumor_incidence1.29062325
46MP0002086_abnormal_extraembryonic_tissu1.28903516
47MP0003436_decreased_susceptibility_to1.28692585
48MP0000689_abnormal_spleen_morphology1.27893088
49* MP0002080_prenatal_lethality1.27230772
50MP0001697_abnormal_embryo_size1.26871764
51MP0000015_abnormal_ear_pigmentation1.26430867
52MP0002452_abnormal_antigen_presenting1.25935705
53MP0000703_abnormal_thymus_morphology1.24196616
54MP0003890_abnormal_embryonic-extraembry1.23887968
55MP0003172_abnormal_lysosome_physiology1.23667037
56MP0003221_abnormal_cardiomyocyte_apopto1.22950012
57MP0002429_abnormal_blood_cell1.21310471
58MP0002132_abnormal_respiratory_system1.19566748
59MP0004197_abnormal_fetal_growth/weight/1.17520557
60MP0000716_abnormal_immune_system1.16929149
61MP0002723_abnormal_immune_serum1.16388263
62MP0002084_abnormal_developmental_patter1.16208221
63MP0000313_abnormal_cell_death1.16117031
64MP0003705_abnormal_hypodermis_morpholog1.15516603
65MP0002085_abnormal_embryonic_tissue1.14930652
66MP0002420_abnormal_adaptive_immunity1.14677355
67MP0001819_abnormal_immune_cell1.13169152
68MP0000537_abnormal_urethra_morphology1.12819340
69MP0002877_abnormal_melanocyte_morpholog1.12711038
70MP0005464_abnormal_platelet_physiology1.09083571
71MP0002166_altered_tumor_susceptibility1.08716555
72MP0005058_abnormal_lysosome_morphology1.07832197
73MP0000371_diluted_coat_color1.05876708
74MP0005174_abnormal_tail_pigmentation1.04725110
75MP0009697_abnormal_copulation1.04670775
76MP0002092_abnormal_eye_morphology1.04549912
77MP0002405_respiratory_system_inflammati1.03387092
78MP0009672_abnormal_birth_weight1.02862636
79MP0005384_cellular_phenotype1.02368274
80MP0002419_abnormal_innate_immunity1.02103636
81MP0001873_stomach_inflammation0.98895880
82MP0005000_abnormal_immune_tolerance0.97136222
83MP0002210_abnormal_sex_determination0.96922604
84MP0008995_early_reproductive_senescence0.96603470
85MP0001661_extended_life_span0.95862805
86MP0006292_abnormal_olfactory_placode0.91957708
87MP0003718_maternal_effect0.91611911
88MP0000358_abnormal_cell_content/0.91153621
89MP0003183_abnormal_peptide_metabolism0.91090586
90MP0004782_abnormal_surfactant_physiolog0.90975619
91MP0003567_abnormal_fetal_cardiomyocyte0.90476979
92MP0005083_abnormal_biliary_tract0.90348432
93MP0003943_abnormal_hepatobiliary_system0.90235715
94MP0002928_abnormal_bile_duct0.90098247
95MP0002697_abnormal_eye_size0.89890737
96MP0003566_abnormal_cell_adhesion0.89262820
97MP0001915_intracranial_hemorrhage0.88947106
98MP0009703_decreased_birth_body0.88392867
99MP0000858_altered_metastatic_potential0.88037649
100MP0006035_abnormal_mitochondrial_morpho0.86047922
101MP0003448_altered_tumor_morphology0.85803712
102MP0009333_abnormal_splenocyte_physiolog0.85434779
103MP0005025_abnormal_response_to0.85284929
104MP0002075_abnormal_coat/hair_pigmentati0.84453880
105MP0001145_abnormal_male_reproductive0.83778774
106MP0009785_altered_susceptibility_to0.83568359
107MP0000627_abnormal_mammary_gland0.83361988
108MP0001929_abnormal_gametogenesis0.83101688
109MP0003300_gastrointestinal_ulcer0.81928626
110MP0001293_anophthalmia0.80176694
111MP0005023_abnormal_wound_healing0.80029319
112MP0000733_abnormal_muscle_development0.79947426
113MP0003303_peritoneal_inflammation0.79787720
114MP0000465_gastrointestinal_hemorrhage0.79446276
115MP0010155_abnormal_intestine_physiology0.79086702
116MP0002095_abnormal_skin_pigmentation0.78946840
117MP0002006_tumorigenesis0.78837648
118MP0001849_ear_inflammation0.78757418
119MP0005623_abnormal_meninges_morphology0.77492420
120MP0000653_abnormal_sex_gland0.76507103
121MP0003191_abnormal_cellular_cholesterol0.76245472
122MP0001853_heart_inflammation0.75458069
123MP0001919_abnormal_reproductive_system0.74669903
124MP0005310_abnormal_salivary_gland0.74122679
125MP0001186_pigmentation_phenotype0.73663438
126MP0000598_abnormal_liver_morphology0.72809864
127MP0004264_abnormal_extraembryonic_tissu0.72007604
128MP0003315_abnormal_perineum_morphology0.71913209
129MP0001119_abnormal_female_reproductive0.70888510
130MP0003121_genomic_imprinting0.70579541
131MP0010234_abnormal_vibrissa_follicle0.70533011
132MP0000428_abnormal_craniofacial_morphol0.70289155
133MP0005621_abnormal_cell_physiology0.69836700
134MP0010030_abnormal_orbit_morphology0.66834025
135MP0005220_abnormal_exocrine_pancreas0.65630193
136MP0003091_abnormal_cell_migration0.64284609
137MP0009053_abnormal_anal_canal0.63210703
138MP0003115_abnormal_respiratory_system0.61584806
139MP0005408_hypopigmentation0.61318522
140MP0002111_abnormal_tail_morphology0.60779872

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.03034105
2Reticulocytopenia (HP:0001896)3.60655093
3Ectopic kidney (HP:0000086)3.52514944
4Chromsome breakage (HP:0040012)3.35168223
5Colon cancer (HP:0003003)3.17311120
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06564002
7Ependymoma (HP:0002888)3.02692520
811 pairs of ribs (HP:0000878)2.99379931
9Squamous cell carcinoma (HP:0002860)2.97641836
10Breast hypoplasia (HP:0003187)2.97234082
11Absent thumb (HP:0009777)2.91562176
12Progressive muscle weakness (HP:0003323)2.82440143
13Abnormality of cells of the erythroid lineage (HP:0012130)2.74902434
14Abnormality of the carotid arteries (HP:0005344)2.74787981
15Myelodysplasia (HP:0002863)2.68546400
16Abnormality of pyrimidine metabolism (HP:0004353)2.63409597
17Abnormal number of erythroid precursors (HP:0012131)2.63247774
18Selective tooth agenesis (HP:0001592)2.62313271
19Volvulus (HP:0002580)2.62250421
20Patellar aplasia (HP:0006443)2.55772657
21Increased nuchal translucency (HP:0010880)2.51673563
22Clubbing of toes (HP:0100760)2.51554512
23Abnormality of the lower motor neuron (HP:0002366)2.50333632
24Agnosia (HP:0010524)2.50247870
25Thrombocytosis (HP:0001894)2.47959055
26Medulloblastoma (HP:0002885)2.44998582
27Deep philtrum (HP:0002002)2.41182198
28Abnormality of chromosome stability (HP:0003220)2.39884376
29Abnormality of reticulocytes (HP:0004312)2.35423062
30Aplasia/Hypoplasia of the patella (HP:0006498)2.33254393
31Upper motor neuron abnormality (HP:0002127)2.33228962
32Prominent nose (HP:0000448)2.32497013
33Basal cell carcinoma (HP:0002671)2.32393759
34Multiple enchondromatosis (HP:0005701)2.30467215
35Deep palmar crease (HP:0006191)2.30258183
36Progressive external ophthalmoplegia (HP:0000590)2.29536546
37Hematochezia (HP:0002573)2.29024385
38Prolonged bleeding time (HP:0003010)2.28220444
39Glioma (HP:0009733)2.25691052
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.25547672
41Short thumb (HP:0009778)2.21123482
42Pallor (HP:0000980)2.20677685
43Impulsivity (HP:0100710)2.20227303
44Bone marrow hypocellularity (HP:0005528)2.19378407
45Obsessive-compulsive behavior (HP:0000722)2.18720330
46Broad distal phalanx of finger (HP:0009836)2.16714031
47High anterior hairline (HP:0009890)2.16677011
48Abnormality of chromosome segregation (HP:0002916)2.16342946
49Abnormality of DNA repair (HP:0003254)2.16003246
50Microvesicular hepatic steatosis (HP:0001414)2.15632831
51Aplastic anemia (HP:0001915)2.14248937
52Meckel diverticulum (HP:0002245)2.12156405
53Premature graying of hair (HP:0002216)2.12093453
54Subacute progressive viral hepatitis (HP:0006572)2.12019214
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11382215
56Hyperacusis (HP:0010780)2.09822740
57Broad face (HP:0000283)2.07712753
58Hypoplasia of the radius (HP:0002984)2.07525414
59Proximal placement of thumb (HP:0009623)2.05809470
60Absent radius (HP:0003974)2.05756810
61Abnormality of the fingertips (HP:0001211)2.05562468
62Abnormal number of incisors (HP:0011064)2.05452341
63Neoplasm of the adrenal cortex (HP:0100641)2.04466346
64Deviation of the thumb (HP:0009603)2.04295035
65Abnormal foot bone ossification (HP:0010675)2.03749048
66Overlapping toe (HP:0001845)2.03234829
67Dislocated radial head (HP:0003083)2.02818908
68Abnormality of the phalanges of the hallux (HP:0010057)2.00109911
69Pendular nystagmus (HP:0012043)1.99010718
70Dysautonomia (HP:0002459)1.98682466
71Heterotopia (HP:0002282)1.98389480
72Rectal prolapse (HP:0002035)1.97610043
73Aplasia/hypoplasia of the humerus (HP:0006507)1.96670318
74Abnormality of the radial head (HP:0003995)1.96206319
75Long eyelashes (HP:0000527)1.95400193
76Neoplasm of the oral cavity (HP:0100649)1.95398543
77Abnormality of the ileum (HP:0001549)1.94549679
78Poikiloderma (HP:0001029)1.93637083
79Recurrent viral infections (HP:0004429)1.92986037
80Nephroblastoma (Wilms tumor) (HP:0002667)1.92385496
81Hypoplasia of the pons (HP:0012110)1.91750410
82Ulnar bowing (HP:0003031)1.90810650
83Rhabdomyosarcoma (HP:0002859)1.89784974
84Abnormal delayed hypersensitivity skin test (HP:0002963)1.89508560
85Arteriovenous malformation (HP:0100026)1.89288516
86Entropion (HP:0000621)1.89078498
87Abnormality of cells of the lymphoid lineage (HP:0012140)1.88853316
88Urethral obstruction (HP:0000796)1.88391224
89Supernumerary ribs (HP:0005815)1.88331200
90Abnormal platelet volume (HP:0011876)1.87754815
91Pulmonary fibrosis (HP:0002206)1.86723729
92Anal stenosis (HP:0002025)1.86610363
93Aplasia involving forearm bones (HP:0009822)1.86330408
94Absent forearm bone (HP:0003953)1.86330408
95Abnormality of the columella (HP:0009929)1.85636139
96Duplicated collecting system (HP:0000081)1.85420645
97Choanal atresia (HP:0000453)1.84265354
98Abnormality of the duodenum (HP:0002246)1.84231302
99Granulocytopenia (HP:0001913)1.84006682
100IgM deficiency (HP:0002850)1.83958845
101Hypopigmentation of the fundus (HP:0007894)1.83248465
102Abnormality of the labia minora (HP:0012880)1.83030569
103Sparse lateral eyebrow (HP:0005338)1.82913318
104Abnormality of the distal phalanges of the toes (HP:0010182)1.81994091
105Chronic obstructive pulmonary disease (HP:0006510)1.81013149
106Obstructive lung disease (HP:0006536)1.81013149
107Supernumerary bones of the axial skeleton (HP:0009144)1.80157301
108Embryonal renal neoplasm (HP:0011794)1.80100588
109Renal cell carcinoma (HP:0005584)1.79495981
110Missing ribs (HP:0000921)1.79427785
111Long palpebral fissure (HP:0000637)1.79012286
112Duodenal stenosis (HP:0100867)1.78878202
113Small intestinal stenosis (HP:0012848)1.78878202
114Lymphoma (HP:0002665)1.78867298
115Eosinophilia (HP:0001880)1.78785397
116Amaurosis fugax (HP:0100576)1.78462863
117Sandal gap (HP:0001852)1.78010870
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.77126616
119High pitched voice (HP:0001620)1.76763172
120Patellar dislocation (HP:0002999)1.76256195
121Abnormal spermatogenesis (HP:0008669)1.76055139
122Carpal bone hypoplasia (HP:0001498)1.75897164
123Abnormality of the preputium (HP:0100587)1.75483482
124Lymphopenia (HP:0001888)1.75429847
125Cafe-au-lait spot (HP:0000957)1.75099874
126Macrocytic anemia (HP:0001972)1.74499635
127Trigonocephaly (HP:0000243)1.73835016
128Tracheoesophageal fistula (HP:0002575)1.73620558
129Tongue fasciculations (HP:0001308)1.72821231
130Trismus (HP:0000211)1.72736461
131Hand muscle atrophy (HP:0009130)1.72447984
132Sloping forehead (HP:0000340)1.72006797
133Intestinal fistula (HP:0100819)1.71556254
134Recurrent fungal infections (HP:0002841)1.71397786
135Aplasia/Hypoplasia of the thymus (HP:0010515)1.70876478
136Recurrent abscess formation (HP:0002722)1.70855545
137Atresia of the external auditory canal (HP:0000413)1.69869755
138Neoplasm of striated muscle (HP:0009728)1.69011019
139Facial hemangioma (HP:0000329)1.68981109
140Capillary hemangiomas (HP:0005306)1.68565067
141Combined immunodeficiency (HP:0005387)1.67570654
142Amyotrophic lateral sclerosis (HP:0007354)1.67439722
143Preauricular skin tag (HP:0000384)1.67241282
144Low anterior hairline (HP:0000294)1.66795277
145Spinal cord lesions (HP:0100561)1.65515968
146Syringomyelia (HP:0003396)1.65515968
147Astrocytoma (HP:0009592)1.65289582
148Abnormality of the astrocytes (HP:0100707)1.65289582
149Viral hepatitis (HP:0006562)1.65224300
150Acute lymphatic leukemia (HP:0006721)1.63137687
151Leiomyosarcoma (HP:0100243)1.63090412
152Uterine leiomyosarcoma (HP:0002891)1.63090412
153Elfin facies (HP:0004428)1.62890025
154Skin tags (HP:0010609)1.61938105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.53640202
2SMG14.21898484
3CDC73.88129703
4CDK123.51539830
5EEF2K3.20079276
6SRPK12.87979059
7ICK2.76310357
8WEE12.67810343
9TAF12.58380064
10SCYL22.55872750
11NEK22.31270432
12CAMK1D2.14084647
13RPS6KB22.04439676
14MAP4K12.03526869
15IRAK31.99452364
16STK101.85881931
17EIF2AK11.84285638
18PASK1.81144796
19CAMK1G1.77026046
20TSSK61.66330546
21TTK1.63803226
22PLK11.62913093
23ATR1.60700522
24CDK71.59907921
25MAP2K31.58969624
26CDK41.56981201
27NME21.50003308
28TLK11.47633032
29PRPF4B1.42911442
30MAP3K101.42239074
31PKN21.41055629
32CHEK11.37985526
33BTK1.36299929
34AURKB1.35095792
35VRK21.31300480
36TYK21.29322437
37STK41.25354353
38RPS6KA41.20012287
39MELK1.18021683
40ALK1.15438554
41CHEK21.13423855
42PAK41.13125555
43PIM11.11346654
44GRK61.11303725
45PLK31.10561524
46BRSK11.09893998
47CDK61.09554813
48BRSK21.08706315
49MAP3K141.07244521
50CDK81.05471661
51TTN1.03992750
52MAP3K81.03922231
53ZAK1.03024681
54PLK41.01082826
55ERN11.00407334
56FLT30.99594294
57ATM0.99175045
58CDK20.98311014
59CSF1R0.97031619
60BRD40.96561072
61MTOR0.93464889
62CLK10.91421666
63VRK10.91321642
64NEK10.90001088
65EPHA20.88769332
66ACVR1B0.88195016
67IKBKB0.86474732
68CHUK0.82324706
69JAK30.80627097
70MKNK10.80234520
71PTK60.79625899
72SIK30.77039247
73RAF10.76216366
74ZAP700.75940769
75PAK20.75150662
76MAP3K30.75033227
77BLK0.73402158
78KIT0.72463014
79KSR20.69877487
80YES10.69783174
81LRRK20.67043413
82PBK0.66990133
83AURKA0.66348134
84STK30.64959734
85TBK10.62651160
86PRKCI0.60631620
87STK240.59920873
88CDK10.59400260
89CSNK1D0.59007322
90TESK10.58514610
91MAP3K130.56427787
92CSNK2A10.56174668
93PNCK0.55778265
94BRAF0.55305565
95MKNK20.54327979
96DYRK30.54314889
97FGFR40.50774924
98TEC0.49513987
99TRIB30.48951860
100CSNK2A20.48931209
101AKT20.46328777
102RPS6KA10.46168861
103PRKDC0.43628352
104CAMKK10.42223208
105RPS6KL10.41340071
106RPS6KC10.41340071
107PDK20.41226847
108IRAK20.39153938
109LYN0.38994535
110CCNB10.38796687
111SIK20.38506460
112UHMK10.38265257
113SYK0.38109615
114ABL20.38080196
115CAMK40.37952094
116KSR10.37810819
117HCK0.37458758
118MAPK10.37307965
119MARK30.36938911
120LCK0.36824830
121DYRK1B0.36730966
122TRPM70.35451832
123AKT10.35031705
124CSNK1A1L0.34899223
125RPS6KA60.33056712
126MAP3K50.32480409
127IRAK40.32301185
128MAPK110.31923935
129IRAK10.31667319
130SIK10.31645481
131CDK90.31118377
132MAPK140.30583497
133GSK3B0.29920341
134MAPKAPK20.27940885

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52685034
2Mismatch repair_Homo sapiens_hsa034303.64257814
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20644328
4One carbon pool by folate_Homo sapiens_hsa006703.16677777
5* Homologous recombination_Homo sapiens_hsa034402.87449748
6RNA transport_Homo sapiens_hsa030132.76683975
7Spliceosome_Homo sapiens_hsa030402.59066879
8Base excision repair_Homo sapiens_hsa034102.46850749
9Cell cycle_Homo sapiens_hsa041102.34344947
10Nucleotide excision repair_Homo sapiens_hsa034202.32451725
11Ribosome_Homo sapiens_hsa030102.21641172
12* Fanconi anemia pathway_Homo sapiens_hsa034602.21292644
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19655546
14Non-homologous end-joining_Homo sapiens_hsa034502.08240938
15Proteasome_Homo sapiens_hsa030501.96938401
16RNA polymerase_Homo sapiens_hsa030201.86135194
17mRNA surveillance pathway_Homo sapiens_hsa030151.68741596
18Non-small cell lung cancer_Homo sapiens_hsa052231.67455344
19Pyrimidine metabolism_Homo sapiens_hsa002401.66494018
20p53 signaling pathway_Homo sapiens_hsa041151.63214492
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.59831504
22RNA degradation_Homo sapiens_hsa030181.52394552
23Bladder cancer_Homo sapiens_hsa052191.44583266
24Antigen processing and presentation_Homo sapiens_hsa046121.37032190
25Systemic lupus erythematosus_Homo sapiens_hsa053221.35308873
26Folate biosynthesis_Homo sapiens_hsa007901.26086669
27Herpes simplex infection_Homo sapiens_hsa051681.25707817
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19232431
29Prostate cancer_Homo sapiens_hsa052151.17262529
30Basal transcription factors_Homo sapiens_hsa030221.16804576
31Selenocompound metabolism_Homo sapiens_hsa004501.16587928
32Colorectal cancer_Homo sapiens_hsa052101.11121406
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09550963
34Viral carcinogenesis_Homo sapiens_hsa052031.08095600
35Primary immunodeficiency_Homo sapiens_hsa053401.07823861
36Small cell lung cancer_Homo sapiens_hsa052221.07764870
37Endometrial cancer_Homo sapiens_hsa052131.07585456
38Epstein-Barr virus infection_Homo sapiens_hsa051691.04932392
39Notch signaling pathway_Homo sapiens_hsa043301.03297991
40Measles_Homo sapiens_hsa051621.01690683
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00182205
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00084379
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95899052
44Alcoholism_Homo sapiens_hsa050340.95363425
45HTLV-I infection_Homo sapiens_hsa051660.94997326
46N-Glycan biosynthesis_Homo sapiens_hsa005100.90105282
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90093594
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86394131
49B cell receptor signaling pathway_Homo sapiens_hsa046620.85854404
50Legionellosis_Homo sapiens_hsa051340.85625946
51Glioma_Homo sapiens_hsa052140.83208817
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.81305134
53Renal cell carcinoma_Homo sapiens_hsa052110.81258601
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80925163
55Basal cell carcinoma_Homo sapiens_hsa052170.80897080
56Apoptosis_Homo sapiens_hsa042100.79875795
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79864408
58Pentose phosphate pathway_Homo sapiens_hsa000300.79698144
59Leishmaniasis_Homo sapiens_hsa051400.79133368
60Influenza A_Homo sapiens_hsa051640.78428997
61Biosynthesis of amino acids_Homo sapiens_hsa012300.74848734
62Lysine degradation_Homo sapiens_hsa003100.72692659
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72541427
64Hepatitis B_Homo sapiens_hsa051610.72240662
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71364516
66MicroRNAs in cancer_Homo sapiens_hsa052060.71197337
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.69976739
68Purine metabolism_Homo sapiens_hsa002300.67505262
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67420251
70Chronic myeloid leukemia_Homo sapiens_hsa052200.66651695
71Hedgehog signaling pathway_Homo sapiens_hsa043400.66253463
72Hematopoietic cell lineage_Homo sapiens_hsa046400.65099082
73FoxO signaling pathway_Homo sapiens_hsa040680.64326105
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.61455233
75Acute myeloid leukemia_Homo sapiens_hsa052210.60450160
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.60442250
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58292098
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57449563
79Staphylococcus aureus infection_Homo sapiens_hsa051500.56605050
80Inositol phosphate metabolism_Homo sapiens_hsa005620.55099939
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.54777245
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54746249
83Osteoclast differentiation_Homo sapiens_hsa043800.54431528
84Hepatitis C_Homo sapiens_hsa051600.53353350
85Allograft rejection_Homo sapiens_hsa053300.53344858
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.53252302
87Melanoma_Homo sapiens_hsa052180.52648510
88ErbB signaling pathway_Homo sapiens_hsa040120.51280579
89Insulin signaling pathway_Homo sapiens_hsa049100.47195424
90VEGF signaling pathway_Homo sapiens_hsa043700.46534450
91AMPK signaling pathway_Homo sapiens_hsa041520.46061450
92Adherens junction_Homo sapiens_hsa045200.45790602
93Thyroid cancer_Homo sapiens_hsa052160.44905761
94Proteoglycans in cancer_Homo sapiens_hsa052050.44830165
95Pertussis_Homo sapiens_hsa051330.44108080
96Other glycan degradation_Homo sapiens_hsa005110.43607857
97Type I diabetes mellitus_Homo sapiens_hsa049400.42757305
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42194173
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.42032224
100HIF-1 signaling pathway_Homo sapiens_hsa040660.41909119
101Galactose metabolism_Homo sapiens_hsa000520.41865435
102Oocyte meiosis_Homo sapiens_hsa041140.41795995
103Fructose and mannose metabolism_Homo sapiens_hsa000510.41677622
104Prolactin signaling pathway_Homo sapiens_hsa049170.40957816
105TNF signaling pathway_Homo sapiens_hsa046680.40867958
106Toxoplasmosis_Homo sapiens_hsa051450.40735918
107T cell receptor signaling pathway_Homo sapiens_hsa046600.40442704
108Sulfur relay system_Homo sapiens_hsa041220.40085351
109Pathways in cancer_Homo sapiens_hsa052000.39698806
110TGF-beta signaling pathway_Homo sapiens_hsa043500.38945322
111Viral myocarditis_Homo sapiens_hsa054160.38940222
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38695394
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38267389
114Graft-versus-host disease_Homo sapiens_hsa053320.37377952
115Insulin resistance_Homo sapiens_hsa049310.36086027
116Shigellosis_Homo sapiens_hsa051310.35768858
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34913702
118mTOR signaling pathway_Homo sapiens_hsa041500.34580100
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34187428
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.31986403
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30110258
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28366829
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28121043
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27183173
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26834121
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.26510170
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26246702
128Pancreatic cancer_Homo sapiens_hsa052120.26214143
129Lysosome_Homo sapiens_hsa041420.25918411
130Vitamin B6 metabolism_Homo sapiens_hsa007500.25302522
131Tuberculosis_Homo sapiens_hsa051520.23834013

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