TOP3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.80629441
2DNA unwinding involved in DNA replication (GO:0006268)4.23222259
3negative regulation of erythrocyte differentiation (GO:0045647)4.19270684
4regulation of RNA export from nucleus (GO:0046831)4.15299070
5DNA strand elongation involved in DNA replication (GO:0006271)4.05946307
6COPI coating of Golgi vesicle (GO:0048205)3.98254304
7Golgi transport vesicle coating (GO:0048200)3.98254304
8IMP biosynthetic process (GO:0006188)3.98207010
9DNA replication initiation (GO:0006270)3.94762263
10telomere maintenance via semi-conservative replication (GO:0032201)3.92561444
11DNA strand elongation (GO:0022616)3.88745973
12protein localization to kinetochore (GO:0034501)3.88154849
13proline biosynthetic process (GO:0006561)3.85468777
14DNA deamination (GO:0045006)3.85190979
15nucleosome disassembly (GO:0006337)3.82583142
16protein-DNA complex disassembly (GO:0032986)3.82583142
17regulation of histone H3-K9 methylation (GO:0051570)3.82220841
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.70866416
19maturation of SSU-rRNA (GO:0030490)3.56504250
20DNA duplex unwinding (GO:0032508)3.55217769
21negative regulation of histone methylation (GO:0031061)3.54465386
22DNA geometric change (GO:0032392)3.54101533
23protein export from nucleus (GO:0006611)3.53353371
24protein localization to chromosome, centromeric region (GO:0071459)3.53206356
25regulation of nucleobase-containing compound transport (GO:0032239)3.50440171
26peptidyl-arginine omega-N-methylation (GO:0035247)3.48161684
27mitotic nuclear envelope disassembly (GO:0007077)3.47083519
28IMP metabolic process (GO:0046040)3.45981652
29nuclear pore complex assembly (GO:0051292)3.43496145
30telomere maintenance via recombination (GO:0000722)3.43309188
31nuclear pore organization (GO:0006999)3.42215289
32regulation of histone H3-K4 methylation (GO:0051569)3.40630683
33mannose metabolic process (GO:0006013)3.39935656
34poly(A)+ mRNA export from nucleus (GO:0016973)3.36483540
35histone H4 deacetylation (GO:0070933)3.31283406
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29445216
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.28370469
38folic acid-containing compound biosynthetic process (GO:0009396)3.27108149
39mitotic recombination (GO:0006312)3.25503080
40nucleobase biosynthetic process (GO:0046112)3.24447538
41nuclear envelope organization (GO:0006998)3.23674238
42telomere maintenance via telomere lengthening (GO:0010833)3.21116593
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19239837
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.19239837
45membrane disassembly (GO:0030397)3.15243334
46nuclear envelope disassembly (GO:0051081)3.15243334
47viral transcription (GO:0019083)3.14569710
48erythrocyte maturation (GO:0043249)3.14033944
49protoporphyrinogen IX metabolic process (GO:0046501)3.11806189
50retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11681902
51negative regulation of RNA splicing (GO:0033119)3.10536318
52mitotic sister chromatid cohesion (GO:0007064)3.10224762
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09943842
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09943842
55regulation of helicase activity (GO:0051095)3.08337243
56glucose 6-phosphate metabolic process (GO:0051156)3.06521721
57antigen processing and presentation via MHC class Ib (GO:0002475)3.03099461
58translational termination (GO:0006415)3.03095116
59regulation of histone methylation (GO:0031060)3.02984417
60mRNA transport (GO:0051028)3.02243863
61DNA replication checkpoint (GO:0000076)3.01593731
62translesion synthesis (GO:0019985)3.01263543
63negative regulation of DNA-templated transcription, elongation (GO:0032785)2.97602342
64determination of adult lifespan (GO:0008340)2.96937825
65mRNA export from nucleus (GO:0006406)2.96664334
66mitochondrial DNA metabolic process (GO:0032042)2.94761150
67mismatch repair (GO:0006298)2.91785988
68intracellular estrogen receptor signaling pathway (GO:0030520)2.90550045
69mRNA stabilization (GO:0048255)2.89787286
70RNA stabilization (GO:0043489)2.89787286
71telomere maintenance (GO:0000723)2.89391486
72translational elongation (GO:0006414)2.89232145
73chromatin assembly (GO:0031497)2.88632261
74histone H2A acetylation (GO:0043968)2.87406171
75telomere organization (GO:0032200)2.86746589
76protoporphyrinogen IX biosynthetic process (GO:0006782)2.86476083
77RNA export from nucleus (GO:0006405)2.86049189
78positive regulation of gamma-delta T cell activation (GO:0046645)2.85180007
79peptidyl-arginine methylation (GO:0018216)2.82010208
80peptidyl-arginine N-methylation (GO:0035246)2.82010208
81* DNA conformation change (GO:0071103)2.81901540
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.80330090
83chromosome condensation (GO:0030261)2.78605456
84histone mRNA catabolic process (GO:0071044)2.77239258
85pre-miRNA processing (GO:0031054)2.77135542
86formation of translation preinitiation complex (GO:0001731)2.76143874
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75479470
88dosage compensation (GO:0007549)2.75242151
89meiotic chromosome segregation (GO:0045132)2.75139341
90DNA replication-dependent nucleosome assembly (GO:0006335)2.74688905
91DNA replication-dependent nucleosome organization (GO:0034723)2.74688905
92heterochromatin organization (GO:0070828)2.73762943
93intra-S DNA damage checkpoint (GO:0031573)2.73471176
94homocysteine metabolic process (GO:0050667)2.73246002
95negative regulation of mRNA processing (GO:0050686)2.72861679
96regulation of NFAT protein import into nucleus (GO:0051532)2.72703904
97purine nucleobase biosynthetic process (GO:0009113)2.72576587
98base-excision repair (GO:0006284)2.70106839
99antigen processing and presentation of endogenous antigen (GO:0019883)2.70088861
100mitotic sister chromatid segregation (GO:0000070)2.70070829
101proline metabolic process (GO:0006560)2.68744032
102L-serine metabolic process (GO:0006563)2.68655902
103viral mRNA export from host cell nucleus (GO:0046784)2.68543308
104* DNA topological change (GO:0006265)2.68288495
105tRNA aminoacylation for protein translation (GO:0006418)2.66578655
106regulation of gene silencing by RNA (GO:0060966)2.66483256
107regulation of posttranscriptional gene silencing (GO:0060147)2.66483256
108regulation of gene silencing by miRNA (GO:0060964)2.66483256
109pore complex assembly (GO:0046931)2.66395335
110ribosome biogenesis (GO:0042254)2.66274500
111snRNA processing (GO:0016180)2.66112102
112ribosomal small subunit biogenesis (GO:0042274)2.66026581
113granulocyte differentiation (GO:0030851)2.65073874
114DNA replication-independent nucleosome assembly (GO:0006336)2.64831782
115DNA replication-independent nucleosome organization (GO:0034724)2.64831782
116chromatin remodeling at centromere (GO:0031055)2.64722007
117DNA synthesis involved in DNA repair (GO:0000731)2.63458653
118histone H3-K4 methylation (GO:0051568)2.63171237
119histone H3 deacetylation (GO:0070932)2.62952856
120regulation of chromatin binding (GO:0035561)2.62712208
121sister chromatid segregation (GO:0000819)2.62660535
122histone arginine methylation (GO:0034969)2.61991594
123regulation of translational fidelity (GO:0006450)2.61623012
124negative regulation of gene expression, epigenetic (GO:0045814)2.60358745
125nucleic acid transport (GO:0050657)2.59213179
126RNA transport (GO:0050658)2.59213179
127establishment of RNA localization (GO:0051236)2.59213179
128nuclear export (GO:0051168)2.58209903
129regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57946777
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57823303
1313-UTR-mediated mRNA stabilization (GO:0070935)2.57667961
132chromatin assembly or disassembly (GO:0006333)2.57236121
133mRNA cleavage (GO:0006379)2.56917785
134CENP-A containing nucleosome assembly (GO:0034080)2.56586118
135amino acid activation (GO:0043038)2.56456665
136tRNA aminoacylation (GO:0043039)2.56456665
137ribonucleoprotein complex biogenesis (GO:0022613)2.54938644
138DNA damage induced protein phosphorylation (GO:0006975)2.54773424
139definitive hemopoiesis (GO:0060216)2.54482428
140mitotic metaphase plate congression (GO:0007080)2.53908057
141regulation of DNA damage checkpoint (GO:2000001)2.53896416
142negative regulation of mRNA metabolic process (GO:1903312)2.53713988
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53531938
144translational initiation (GO:0006413)2.53195727
145mitotic chromosome condensation (GO:0007076)2.52889968
146regulation of spindle organization (GO:0090224)2.52449907
147regulation of histone H3-K27 methylation (GO:0061085)2.51561708
148regulation of gene silencing (GO:0060968)2.51452304
149positive regulation of DNA-dependent DNA replication (GO:2000105)2.50841780
150positive regulation of B cell differentiation (GO:0045579)2.50837160
151snRNA metabolic process (GO:0016073)2.50626533
152cellular hyperosmotic response (GO:0071474)2.48750218
153kinetochore organization (GO:0051383)2.48170609
154regulation of mitotic spindle organization (GO:0060236)2.47000959
155tRNA methylation (GO:0030488)2.45367616
156metaphase plate congression (GO:0051310)2.44299501
157SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44251305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72448594
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.65715686
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.23672537
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17621267
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.08659424
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99165063
7MYC_22102868_ChIP-Seq_BL_Human2.82334266
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66416305
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38027671
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15755758
11CIITA_25753668_ChIP-Seq_RAJI_Human2.13840908
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12745610
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08347851
14SCL_19346495_ChIP-Seq_HPC-7_Human2.01853852
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00825731
16VDR_21846776_ChIP-Seq_THP-1_Human2.00740631
17* NCOR1_26117541_ChIP-Seq_K562_Human1.95200895
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92875101
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.88581215
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85789493
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82290842
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79440404
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.76083617
24XRN2_22483619_ChIP-Seq_HELA_Human1.75834980
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72855176
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72263454
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71069203
28LXR_22292898_ChIP-Seq_THP-1_Human1.70996168
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.69504035
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69118580
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67400716
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63245561
33* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63026932
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.62002451
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.61874975
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61405663
37* VDR_23849224_ChIP-Seq_CD4+_Human1.59535638
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59516608
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59295675
40* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58013694
41* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56943723
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55302405
43KDM2B_26808549_Chip-Seq_DND41_Human1.51562418
44CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50925699
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50620919
46SPI1_23547873_ChIP-Seq_NB4_Human1.45749590
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44074558
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41766643
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41509201
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41264663
51TCF7_22412390_ChIP-Seq_EML_Mouse1.40864274
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40138797
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39791021
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39265783
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37802896
56AR_21909140_ChIP-Seq_LNCAP_Human1.34249258
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34115698
58MYB_26560356_Chip-Seq_TH1_Human1.32547393
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31280257
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31238437
61UTX_26944678_Chip-Seq_JUKART_Human1.31121455
62MAF_26560356_Chip-Seq_TH1_Human1.30297400
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.29279372
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.29227767
65RACK7_27058665_Chip-Seq_MCF-7_Human1.28531300
66* GABP_19822575_ChIP-Seq_HepG2_Human1.28461359
67P68_20966046_ChIP-Seq_HELA_Human1.27808499
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.27090859
69* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27029631
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26937823
71MYB_26560356_Chip-Seq_TH2_Human1.26672302
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26623008
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26403979
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26378348
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.26293858
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25275389
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24898053
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24515558
79* TFEB_21752829_ChIP-Seq_HELA_Human1.24082608
80KDM5A_27292631_Chip-Seq_BREAST_Human1.24001048
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21849669
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21762397
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21419079
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20802374
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20735773
86TTF2_22483619_ChIP-Seq_HELA_Human1.20708131
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.20633312
88* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20104040
89ZNF263_19887448_ChIP-Seq_K562_Human1.19950195
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19190362
91DCP1A_22483619_ChIP-Seq_HELA_Human1.16899048
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.15910686
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15822758
94GATA1_19941826_ChIP-Seq_K562_Human1.14837873
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13644158
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13400920
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12446066
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12344112
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11736542
100VDR_24763502_ChIP-Seq_THP-1_Human1.10819618
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08312034
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07695298
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.07502026
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.05928023
105KDM2B_26808549_Chip-Seq_K562_Human1.05208045
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04867473
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04662687
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03267003
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02443063
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02228797
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01562467
112CREB1_26743006_Chip-Seq_LNCaP_Human1.01466638
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01371376
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00890773
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00244568
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99984578
117ELK1_19687146_ChIP-ChIP_HELA_Human0.99653886
118SPI1_23127762_ChIP-Seq_K562_Human0.98372671
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.98173937
120* SRF_21415370_ChIP-Seq_HL-1_Mouse0.96985129
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96954869
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95875751
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.94106320
124* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89829142
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89751652
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89491762
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89185718
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89116890
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88852841
130MAF_26560356_Chip-Seq_TH2_Human0.86809758
131STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85827937
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85640169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.75147890
2MP0010094_abnormal_chromosome_stability3.58989773
3MP0005451_abnormal_body_composition3.56385140
4MP0002396_abnormal_hematopoietic_system3.38271443
5* MP0003111_abnormal_nucleus_morphology3.30759770
6MP0008057_abnormal_DNA_replication3.16077574
7MP0003077_abnormal_cell_cycle3.02841942
8MP0008058_abnormal_DNA_repair2.70140740
9MP0008260_abnormal_autophagy2.68177724
10MP0004957_abnormal_blastocyst_morpholog2.62018226
11MP0008007_abnormal_cellular_replicative2.58646055
12MP0010352_gastrointestinal_tract_polyps2.55556379
13MP0004808_abnormal_hematopoietic_stem2.50604349
14MP0000678_abnormal_parathyroid_gland2.42240586
15MP0000490_abnormal_crypts_of2.20742848
16MP0003763_abnormal_thymus_physiology2.19574769
17MP0001545_abnormal_hematopoietic_system2.06137160
18MP0005397_hematopoietic_system_phenotyp2.06137160
19MP0001835_abnormal_antigen_presentation1.98137537
20MP0005058_abnormal_lysosome_morphology1.94278024
21MP0010307_abnormal_tumor_latency1.89522205
22MP0002398_abnormal_bone_marrow1.86990429
23MP0005083_abnormal_biliary_tract1.84134871
24MP0004233_abnormal_muscle_weight1.81138733
25MP0003656_abnormal_erythrocyte_physiolo1.80109747
26MP0009278_abnormal_bone_marrow1.78391674
27MP0009840_abnormal_foam_cell1.73947443
28MP0000685_abnormal_immune_system1.73206856
29MP0005174_abnormal_tail_pigmentation1.70175200
30MP0003221_abnormal_cardiomyocyte_apopto1.69908647
31MP0001800_abnormal_humoral_immune1.68153330
32MP0000350_abnormal_cell_proliferation1.64083907
33MP0000703_abnormal_thymus_morphology1.62446255
34* MP0002722_abnormal_immune_system1.61809462
35* MP0000689_abnormal_spleen_morphology1.61431669
36MP0005075_abnormal_melanosome_morpholog1.60533138
37MP0002132_abnormal_respiratory_system1.58010302
38MP0002019_abnormal_tumor_incidence1.51362929
39MP0004185_abnormal_adipocyte_glucose1.50181869
40MP0002166_altered_tumor_susceptibility1.48145431
41MP0006035_abnormal_mitochondrial_morpho1.45547977
42MP0001730_embryonic_growth_arrest1.44439448
43MP0002429_abnormal_blood_cell1.44230363
44MP0000716_abnormal_immune_system1.42562578
45MP0005671_abnormal_response_to1.42416219
46MP0002452_abnormal_antigen_presenting1.41925513
47MP0009672_abnormal_birth_weight1.40332658
48MP0000313_abnormal_cell_death1.37663453
49MP0005464_abnormal_platelet_physiology1.36535812
50MP0002420_abnormal_adaptive_immunity1.36534711
51MP0002249_abnormal_larynx_morphology1.36286706
52MP0001819_abnormal_immune_cell1.33951465
53MP0003385_abnormal_body_wall1.30856102
54MP0010155_abnormal_intestine_physiology1.27401037
55MP0005670_abnormal_white_adipose1.26801816
56MP0008877_abnormal_DNA_methylation1.24442852
57MP0002006_tumorigenesis1.23728268
58* MP0003786_premature_aging1.23305868
59MP0002723_abnormal_immune_serum1.23110501
60MP0009333_abnormal_splenocyte_physiolog1.22851736
61MP0005380_embryogenesis_phenotype1.21563220
62MP0001672_abnormal_embryogenesis/_devel1.21563220
63MP0004197_abnormal_fetal_growth/weight/1.20951623
64MP0001661_extended_life_span1.20908205
65MP0002009_preneoplasia1.20359343
66MP0006054_spinal_hemorrhage1.18499823
67MP0002086_abnormal_extraembryonic_tissu1.17228577
68MP0002080_prenatal_lethality1.16803433
69MP0008932_abnormal_embryonic_tissue1.16489271
70MP0003984_embryonic_growth_retardation1.14026408
71MP0005076_abnormal_cell_differentiation1.13253638
72MP0000003_abnormal_adipose_tissue1.13170529
73MP0002877_abnormal_melanocyte_morpholog1.12916694
74MP0003436_decreased_susceptibility_to1.11468541
75MP0002088_abnormal_embryonic_growth/wei1.11105308
76MP0005025_abnormal_response_to1.10070642
77MP0003566_abnormal_cell_adhesion1.10048282
78MP0003303_peritoneal_inflammation1.09562874
79MP0000858_altered_metastatic_potential1.09314572
80MP0004264_abnormal_extraembryonic_tissu1.08472276
81MP0000371_diluted_coat_color1.07958816
82MP0001697_abnormal_embryo_size1.07802773
83MP0000465_gastrointestinal_hemorrhage1.06258404
84MP0002405_respiratory_system_inflammati1.06062751
85MP0001293_anophthalmia1.05666730
86MP0002822_catalepsy1.05186813
87MP0005023_abnormal_wound_healing1.05006131
88* MP0001873_stomach_inflammation1.04899503
89MP0001790_abnormal_immune_system1.04166923
90MP0005387_immune_system_phenotype1.04166923
91MP0003567_abnormal_fetal_cardiomyocyte1.03400002
92MP0009785_altered_susceptibility_to1.02780941
93MP0009931_abnormal_skin_appearance1.00804945
94MP0004858_abnormal_nervous_system1.00168307
95MP0002085_abnormal_embryonic_tissue0.99770077
96MP0002084_abnormal_developmental_patter0.99719950
97MP0002095_abnormal_skin_pigmentation0.98108626
98MP0001853_heart_inflammation0.95254943
99MP0003172_abnormal_lysosome_physiology0.95188677
100MP0010630_abnormal_cardiac_muscle0.94538845
101MP0002419_abnormal_innate_immunity0.92149491
102MP0000477_abnormal_intestine_morphology0.90051711
103MP0000015_abnormal_ear_pigmentation0.89627600
104MP0000598_abnormal_liver_morphology0.89493338
105MP0001348_abnormal_lacrimal_gland0.89043317
106MP0005000_abnormal_immune_tolerance0.88404617
107MP0004147_increased_porphyrin_level0.86740966
108MP0004381_abnormal_hair_follicle0.86238497
109MP0002075_abnormal_coat/hair_pigmentati0.86157185
110MP0006292_abnormal_olfactory_placode0.84770245
111MP0003943_abnormal_hepatobiliary_system0.84515152
112MP0004133_heterotaxia0.84145627
113MP0002970_abnormal_white_adipose0.83177490
114MP0001915_intracranial_hemorrhage0.83038414
115MP0000609_abnormal_liver_physiology0.82623380
116MP0009697_abnormal_copulation0.81136955
117MP0005375_adipose_tissue_phenotype0.80850756
118MP0005666_abnormal_adipose_tissue0.78729490
119MP0003300_gastrointestinal_ulcer0.78025922
120MP0002210_abnormal_sex_determination0.77310358
121MP0005501_abnormal_skin_physiology0.77134382
122MP0003123_paternal_imprinting0.76838659
123MP0003866_abnormal_defecation0.76800637
124MP0003806_abnormal_nucleotide_metabolis0.76128020
125MP0005621_abnormal_cell_physiology0.74955996
126* MP0001845_abnormal_inflammatory_respons0.74492580
127MP0009703_decreased_birth_body0.72595310
128MP0001145_abnormal_male_reproductive0.71932337
129MP0003115_abnormal_respiratory_system0.71381419
130MP0005384_cellular_phenotype0.70522762
131* MP0001929_abnormal_gametogenesis0.70295372
132MP0002089_abnormal_postnatal_growth/wei0.69987380
133MP0002148_abnormal_hypersensitivity_rea0.69012818
134MP0002269_muscular_atrophy0.68746205
135* MP0004947_skin_inflammation0.68035037
136MP0003705_abnormal_hypodermis_morpholog0.67280612
137MP0008961_abnormal_basal_metabolism0.64967209
138MP0003453_abnormal_keratinocyte_physiol0.64755548
139MP0000681_abnormal_thyroid_gland0.64465289
140MP0000358_abnormal_cell_content/0.63628159
141MP0000428_abnormal_craniofacial_morphol0.63371516
142MP0008770_decreased_survivor_rate0.63069968
143MP0001119_abnormal_female_reproductive0.62932473
144MP0001849_ear_inflammation0.61316606
145MP0003941_abnormal_skin_development0.59899336

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.10364593
2Abnormal gallbladder physiology (HP:0012438)5.10364593
3Truncus arteriosus (HP:0001660)4.36215235
4Reticulocytosis (HP:0001923)4.13343223
5Reticulocytopenia (HP:0001896)3.95183593
6Bowel incontinence (HP:0002607)3.88837594
7Abnormal large intestine physiology (HP:0012700)3.73689902
8Chromsome breakage (HP:0040012)3.53948872
9IgM deficiency (HP:0002850)3.53880018
10Thrombocytosis (HP:0001894)3.50440296
11Abnormality of reticulocytes (HP:0004312)3.44860762
12Hypertensive crisis (HP:0100735)3.41080797
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34929164
14Seborrheic dermatitis (HP:0001051)3.32122945
15Hyperthyroidism (HP:0000836)3.27233641
16Recurrent bronchitis (HP:0002837)3.18011954
17Abnormality of the fingertips (HP:0001211)3.11476807
18Aplastic anemia (HP:0001915)3.09970917
19Ependymoma (HP:0002888)3.06319266
20Polycythemia (HP:0001901)3.03015788
2111 pairs of ribs (HP:0000878)3.02910097
22Disproportionate tall stature (HP:0001519)3.00699407
23Selective tooth agenesis (HP:0001592)2.99940057
24Abnormality of DNA repair (HP:0003254)2.83492192
25Myelodysplasia (HP:0002863)2.82774613
26Medulloblastoma (HP:0002885)2.82683147
27Ankyloglossia (HP:0010296)2.68077897
28Microvesicular hepatic steatosis (HP:0001414)2.66225947
29Cortical dysplasia (HP:0002539)2.64696463
30Myositis (HP:0100614)2.64136217
31Cholelithiasis (HP:0001081)2.63932453
32Colon cancer (HP:0003003)2.62156762
33Hypoparathyroidism (HP:0000829)2.60639599
34Abnormality of cells of the erythroid lineage (HP:0012130)2.59007787
35Atelectasis (HP:0100750)2.57190452
36Birth length less than 3rd percentile (HP:0003561)2.56598815
37Agnosia (HP:0010524)2.55219496
38Abnormal number of erythroid precursors (HP:0012131)2.53417564
39Abnormality of chromosome stability (HP:0003220)2.52198194
40Insomnia (HP:0100785)2.51881858
41Recurrent viral infections (HP:0004429)2.50018813
42Amaurosis fugax (HP:0100576)2.49711967
43Prominent nose (HP:0000448)2.49284806
44Abnormality of cochlea (HP:0000375)2.48926159
45Ragged-red muscle fibers (HP:0003200)2.48723246
46Neoplasm of the oral cavity (HP:0100649)2.47579763
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.46883387
48Poikiloderma (HP:0001029)2.45599878
49Acute lymphatic leukemia (HP:0006721)2.43684981
50Cellulitis (HP:0100658)2.43498922
51Patellar dislocation (HP:0002999)2.43148236
52Gastrointestinal inflammation (HP:0004386)2.42630298
53Aplasia/Hypoplasia of the thymus (HP:0010515)2.40393888
54Inflammation of the large intestine (HP:0002037)2.39865554
55Abnormality of T cell physiology (HP:0011840)2.39352074
56Pointed chin (HP:0000307)2.39074612
57Chronic otitis media (HP:0000389)2.38773056
58Hyperacusis (HP:0010780)2.38296979
59Agammaglobulinemia (HP:0004432)2.38143390
60Abnormality of the tricuspid valve (HP:0001702)2.34148247
61Obstructive lung disease (HP:0006536)2.33575225
62Chronic obstructive pulmonary disease (HP:0006510)2.33575225
63High pitched voice (HP:0001620)2.32278400
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.31121024
65Basal cell carcinoma (HP:0002671)2.30989146
66Abnormality of the gallbladder (HP:0005264)2.30062969
67Metaphyseal cupping (HP:0003021)2.29214570
68Absent thumb (HP:0009777)2.27720916
69Distal upper limb amyotrophy (HP:0007149)2.25506685
70Upper limb amyotrophy (HP:0009129)2.25506685
71Prolonged bleeding time (HP:0003010)2.23261677
72Panhypogammaglobulinemia (HP:0003139)2.22567727
73Lymphoma (HP:0002665)2.22225749
74Heterotopia (HP:0002282)2.22014948
75Ectopic kidney (HP:0000086)2.21109482
76Progressive external ophthalmoplegia (HP:0000590)2.21075791
77Meckel diverticulum (HP:0002245)2.20145423
78Abnormality of the preputium (HP:0100587)2.19822082
79Abnormal gallbladder morphology (HP:0012437)2.19177203
80Clubbing of toes (HP:0100760)2.18862250
81Abnormality of glycolysis (HP:0004366)2.18149537
82Overlapping toe (HP:0001845)2.17998106
83Abnormally folded helix (HP:0008544)2.17435063
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.16473601
85Colitis (HP:0002583)2.16373289
86Abnormality of the ileum (HP:0001549)2.15866461
87Pallor (HP:0000980)2.15855157
88Optic nerve coloboma (HP:0000588)2.15075744
89Nasal polyposis (HP:0100582)2.14963520
90Hand muscle atrophy (HP:0009130)2.13930544
91Missing ribs (HP:0000921)2.13871920
92Bone marrow hypocellularity (HP:0005528)2.13388840
93Thin ribs (HP:0000883)2.11904391
94Lymphopenia (HP:0001888)2.11558905
95Abnormality of oral frenula (HP:0000190)2.10717371
96Abnormality of homocysteine metabolism (HP:0010919)2.10164682
97Homocystinuria (HP:0002156)2.10164682
98Abnormality of the renal collecting system (HP:0004742)2.09547896
99Abnormality of the carotid arteries (HP:0005344)2.09312262
100Broad palm (HP:0001169)2.08903545
101Sloping forehead (HP:0000340)2.06651281
102Long palpebral fissure (HP:0000637)2.06397653
103Flat cornea (HP:0007720)2.06311789
104Myopathic facies (HP:0002058)2.03483029
105Increased nuchal translucency (HP:0010880)2.02419448
106Bronchitis (HP:0012387)2.01453685
107Abnormality of the astrocytes (HP:0100707)2.00089248
108Astrocytoma (HP:0009592)2.00089248
109Meningitis (HP:0001287)1.98968391
110Carpal bone hypoplasia (HP:0001498)1.98565087
111Abnormality of T cells (HP:0002843)1.97711442
112Leukopenia (HP:0001882)1.97449736
113Acute myeloid leukemia (HP:0004808)1.96347894
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96249129
115Recurrent fungal infections (HP:0002841)1.96084070
116Breech presentation (HP:0001623)1.95369986
117Duplicated collecting system (HP:0000081)1.94760936
118Morphological abnormality of the inner ear (HP:0011390)1.94653110
119Volvulus (HP:0002580)1.93589955
120Elevated erythrocyte sedimentation rate (HP:0003565)1.92980110
121Long eyelashes (HP:0000527)1.92790659
122Squamous cell carcinoma (HP:0002860)1.91756913
123Abnormality of the nasal mucosa (HP:0000433)1.91535263
124Breast hypoplasia (HP:0003187)1.91401201
125Nonimmune hydrops fetalis (HP:0001790)1.87104430
126Peripheral hypomyelination (HP:0007182)1.86717886
127Progressive muscle weakness (HP:0003323)1.86710340
128Abnormality of pyrimidine metabolism (HP:0004353)1.86362004
129Abnormal number of incisors (HP:0011064)1.85574514
130Rhabdomyosarcoma (HP:0002859)1.85543348
131Abnormality of the calcaneus (HP:0008364)1.83779974
132Petechiae (HP:0000967)1.82725859
133Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82443297
134Small intestinal stenosis (HP:0012848)1.82267826
135Duodenal stenosis (HP:0100867)1.82267826
136Abnormality of the thymus (HP:0000777)1.82267243
137Microretrognathia (HP:0000308)1.82016479
138Cafe-au-lait spot (HP:0000957)1.81347414
139Septate vagina (HP:0001153)1.80678856
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80288226
141Short 4th metacarpal (HP:0010044)1.80288226
142Urethral obstruction (HP:0000796)1.80245732
143Degeneration of anterior horn cells (HP:0002398)1.79806073
144Abnormality of the anterior horn cell (HP:0006802)1.79806073
145Pustule (HP:0200039)1.79634327
146Type I transferrin isoform profile (HP:0003642)1.79477179
147Premature ovarian failure (HP:0008209)1.79404350
148Sandal gap (HP:0001852)1.79199862
149Deep palmar crease (HP:0006191)1.76925276
150Ulnar bowing (HP:0003031)1.76886079
151Cheekbone underdevelopment (HP:0010669)1.76844794
152IgA deficiency (HP:0002720)1.76723511
153Oral leukoplakia (HP:0002745)1.76330706
154Increased connective tissue (HP:0009025)1.75659803
155Increased serum pyruvate (HP:0003542)1.74603885
156Abnormality of the heme biosynthetic pathway (HP:0010472)1.74396993
157High anterior hairline (HP:0009890)1.72815452
158Impulsivity (HP:0100710)1.71547415
159Centrally nucleated skeletal muscle fibers (HP:0003687)1.71186286
160Glioma (HP:0009733)1.71094679
161Obsessive-compulsive behavior (HP:0000722)1.70859724
162Recurrent abscess formation (HP:0002722)1.70581785
163Elfin facies (HP:0004428)1.70519125
164Gastrointestinal dysmotility (HP:0002579)1.70460203
165Muscle fiber atrophy (HP:0100295)1.68716670
166Facial hemangioma (HP:0000329)1.68477991
167Abnormality of B cell number (HP:0010975)1.67623048
168B lymphocytopenia (HP:0010976)1.67623048
169Proximal placement of thumb (HP:0009623)1.67071487
170Tracheoesophageal fistula (HP:0002575)1.66558731
171Abnormality of the aortic arch (HP:0012303)1.66263794
172Osteomyelitis (HP:0002754)1.66109027
173Premature skin wrinkling (HP:0100678)1.66094385
174Ileus (HP:0002595)1.65728088
175Self-mutilation (HP:0000742)1.65726283
176Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65655828
177Abnormality of the thoracic spine (HP:0100711)1.65362839
178Attention deficit hyperactivity disorder (HP:0007018)1.64321950
179Flared metaphyses (HP:0003015)1.64030496
180Neoplasm of the pancreas (HP:0002894)1.63877012
181Spina bifida occulta (HP:0003298)1.61717989
182Deviation of the thumb (HP:0009603)1.61089683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.55241794
2MAP4K13.10891624
3CDC72.80012116
4PRPF4B2.71109666
5SMG12.69635571
6CDK122.58406431
7NEK22.36529645
8WEE12.35027796
9FLT32.31703171
10RPS6KB22.30751515
11RIPK42.28275390
12KSR22.27727472
13MAP3K101.95284846
14PASK1.94351823
15PKN21.92669750
16ATR1.83812895
17TGFBR11.74496250
18BRD41.72792107
19ACVR1B1.68368405
20EPHA21.67793921
21BRSK21.62675098
22KIT1.62018744
23CDK71.61289625
24RAF11.58636651
25STK101.57954195
26ERN11.54116497
27BTK1.53785914
28BUB11.48484341
29MAPKAPK31.45786607
30PIM11.45782806
31TEC1.45375288
32DYRK31.44952716
33TTK1.44722941
34CLK11.44338336
35CDK41.40674156
36EPHA31.39713346
37SCYL21.30408257
38TSSK61.28639816
39MAP2K31.28550700
40NEK11.26242570
41CSF1R1.25847603
42PAK41.23087781
43TIE11.21112670
44JAK31.19815821
45RPS6KA41.16905964
46MAP3K61.13850698
47AURKB1.12268975
48ZAP701.11441730
49PLK11.10030018
50TYK21.09996081
51STK41.08808238
52LRRK21.07382659
53IRAK31.05768877
54NME11.05671674
55NME21.00364113
56BMX0.98907962
57CHEK20.98716019
58TRIB30.95755855
59GRK60.94273692
60MARK20.94143768
61ZAK0.93709030
62BLK0.92172189
63TESK20.91595273
64CHEK10.90163254
65CDK60.90122735
66MAPK110.89627138
67SIK30.88971448
68TGFBR20.85675718
69SRPK10.84620174
70TXK0.83987684
71KDR0.83418256
72TAOK20.83138359
73TBK10.83018962
74MAP3K130.82304023
75MAP3K70.82144925
76CAMK1D0.81751964
77BRAF0.81129923
78MKNK10.81125621
79SYK0.79926656
80EIF2AK30.78850691
81MAP3K80.78169964
82VRK10.77129364
83KSR10.74806087
84EIF2AK10.74633478
85MKNK20.74463096
86PLK40.73215003
87IKBKE0.72480423
88ATM0.72420784
89MAP3K20.71111047
90PDK20.70467783
91PTK60.69997366
92MTOR0.69439723
93CDK10.69085946
94TYRO30.68546755
95EPHB10.68128797
96CHUK0.68076770
97CCNB10.67970747
98FGFR40.67818560
99HCK0.67731882
100CDK20.66624084
101PIM20.66380178
102RET0.64161461
103YES10.62823938
104IKBKB0.62371855
105TAOK30.61146924
106JAK20.59673856
107TLK10.59457699
108NLK0.59008037
109TTN0.58863136
110LYN0.58238765
111BRSK10.58064648
112LCK0.57004544
113STK160.56337715
114MAP3K10.54533500
115AURKA0.51372962
116ICK0.51189650
117ALK0.50877965
118BCKDK0.49611991
119MARK30.48315175
120CDC42BPA0.48307975
121RPS6KA60.48204191
122DYRK1B0.46204322
123SIK10.45334651
124MAPK100.45201311
125ITK0.44899424
126SIK20.44647685
127MATK0.44513370
128IRAK40.43202926
129DAPK10.42872408
130RPS6KC10.42328929
131RPS6KL10.42328929
132EIF2AK20.42208273
133PRKAA10.41082511
134PRKD20.40670346
135PAK10.39320141
136RPS6KA10.39305852
137RIPK10.38053299
138MAP2K60.37836354
139FES0.37344474
140GSK3B0.36594960
141MAPK120.35914540
142MAP2K40.35457899

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62498926
2Mismatch repair_Homo sapiens_hsa034304.05993101
3Base excision repair_Homo sapiens_hsa034103.21064157
4One carbon pool by folate_Homo sapiens_hsa006702.75375302
5Spliceosome_Homo sapiens_hsa030402.55137860
6Non-homologous end-joining_Homo sapiens_hsa034502.52594812
7* Homologous recombination_Homo sapiens_hsa034402.49553678
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47662702
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44321233
10Ribosome_Homo sapiens_hsa030102.31919313
11Nucleotide excision repair_Homo sapiens_hsa034202.30710480
12Cell cycle_Homo sapiens_hsa041102.26431762
13RNA transport_Homo sapiens_hsa030132.24087865
14Primary immunodeficiency_Homo sapiens_hsa053402.21087109
15* Fanconi anemia pathway_Homo sapiens_hsa034602.15850373
16p53 signaling pathway_Homo sapiens_hsa041151.71596360
17Pyrimidine metabolism_Homo sapiens_hsa002401.64174547
18Antigen processing and presentation_Homo sapiens_hsa046121.54460741
19RNA degradation_Homo sapiens_hsa030181.53294887
20Herpes simplex infection_Homo sapiens_hsa051681.49547914
21Pancreatic cancer_Homo sapiens_hsa052121.43565695
22RNA polymerase_Homo sapiens_hsa030201.37563360
23mRNA surveillance pathway_Homo sapiens_hsa030151.36955180
24VEGF signaling pathway_Homo sapiens_hsa043701.32937059
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28195659
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.23145849
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20538878
28mTOR signaling pathway_Homo sapiens_hsa041501.17309013
29Measles_Homo sapiens_hsa051621.15671773
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15000999
31Bladder cancer_Homo sapiens_hsa052191.14695349
32B cell receptor signaling pathway_Homo sapiens_hsa046621.13831600
33Selenocompound metabolism_Homo sapiens_hsa004501.13425534
34Lysine degradation_Homo sapiens_hsa003101.11118626
35ErbB signaling pathway_Homo sapiens_hsa040121.09565590
36Systemic lupus erythematosus_Homo sapiens_hsa053221.09022845
37Hematopoietic cell lineage_Homo sapiens_hsa046401.06884092
38Viral carcinogenesis_Homo sapiens_hsa052031.05376472
39Endometrial cancer_Homo sapiens_hsa052131.04972522
40Epstein-Barr virus infection_Homo sapiens_hsa051691.02882714
41Pentose phosphate pathway_Homo sapiens_hsa000301.01862026
42HTLV-I infection_Homo sapiens_hsa051661.01340701
43Basal transcription factors_Homo sapiens_hsa030220.98550050
44Renal cell carcinoma_Homo sapiens_hsa052110.95393417
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95294254
46Acute myeloid leukemia_Homo sapiens_hsa052210.92785890
47Small cell lung cancer_Homo sapiens_hsa052220.92663648
48Insulin signaling pathway_Homo sapiens_hsa049100.92659565
49Notch signaling pathway_Homo sapiens_hsa043300.91799356
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.88987944
51N-Glycan biosynthesis_Homo sapiens_hsa005100.87748769
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.87502124
53Inositol phosphate metabolism_Homo sapiens_hsa005620.87175385
54Other glycan degradation_Homo sapiens_hsa005110.82013587
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80666201
56Leishmaniasis_Homo sapiens_hsa051400.80311228
57Legionellosis_Homo sapiens_hsa051340.79950087
58Purine metabolism_Homo sapiens_hsa002300.79881600
59Influenza A_Homo sapiens_hsa051640.77875094
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77819788
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.76460633
62Glioma_Homo sapiens_hsa052140.76360494
63Apoptosis_Homo sapiens_hsa042100.75978343
64Steroid biosynthesis_Homo sapiens_hsa001000.75722033
65Chronic myeloid leukemia_Homo sapiens_hsa052200.74042906
66Prostate cancer_Homo sapiens_hsa052150.71314855
67MicroRNAs in cancer_Homo sapiens_hsa052060.70962327
68Choline metabolism in cancer_Homo sapiens_hsa052310.70962212
69Biosynthesis of amino acids_Homo sapiens_hsa012300.70406018
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70104627
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.69714356
72Hepatitis B_Homo sapiens_hsa051610.68692431
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66799405
74Proteasome_Homo sapiens_hsa030500.65065241
75Fructose and mannose metabolism_Homo sapiens_hsa000510.63940173
76Hepatitis C_Homo sapiens_hsa051600.63216291
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62809333
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62479017
79AMPK signaling pathway_Homo sapiens_hsa041520.62204812
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.61717477
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61004729
82Prolactin signaling pathway_Homo sapiens_hsa049170.60524634
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59243697
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.59021372
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57238919
86Galactose metabolism_Homo sapiens_hsa000520.56249056
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.55890036
88Shigellosis_Homo sapiens_hsa051310.55070909
89Thyroid cancer_Homo sapiens_hsa052160.54693580
90Colorectal cancer_Homo sapiens_hsa052100.54266798
91Osteoclast differentiation_Homo sapiens_hsa043800.53119003
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52806532
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52445639
94Type II diabetes mellitus_Homo sapiens_hsa049300.52028070
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50669282
96Folate biosynthesis_Homo sapiens_hsa007900.50188498
97Toxoplasmosis_Homo sapiens_hsa051450.47752436
98Prion diseases_Homo sapiens_hsa050200.47647034
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.46107994
100Pyruvate metabolism_Homo sapiens_hsa006200.45577788
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45451675
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45210210
103HIF-1 signaling pathway_Homo sapiens_hsa040660.44978069
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44355703
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44145366
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44018690
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43310993
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43261050
109Oocyte meiosis_Homo sapiens_hsa041140.43235505
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.41869255
111Non-small cell lung cancer_Homo sapiens_hsa052230.41634028
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41498003
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40296570
114Platelet activation_Homo sapiens_hsa046110.39661525
115Pathways in cancer_Homo sapiens_hsa052000.39439693
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39223242
117T cell receptor signaling pathway_Homo sapiens_hsa046600.38820468
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37293808
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36966941
120Basal cell carcinoma_Homo sapiens_hsa052170.36950964
121Sulfur relay system_Homo sapiens_hsa041220.36570964
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35431889
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35281811
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33276416
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.32552408
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31197591
127Carbon metabolism_Homo sapiens_hsa012000.30816446
128Renin-angiotensin system_Homo sapiens_hsa046140.29271445
129ABC transporters_Homo sapiens_hsa020100.28542702

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