ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.21318808
2	auditory receptor cell differentiation (GO:0042491)	6.61125128
3	protein neddylation (GO:0045116)	5.55471267
4	fucose catabolic process (GO:0019317)	5.53472488
5	L-fucose metabolic process (GO:0042354)	5.53472488
6	L-fucose catabolic process (GO:0042355)	5.53472488
7	neuron fate determination (GO:0048664)	5.20805623
8	axon ensheathment in central nervous system (GO:0032291)	4.96335328
9	central nervous system myelination (GO:0022010)	4.96335328
10	chaperone-mediated protein transport (GO:0072321)	4.83582916
11	ribosomal small subunit biogenesis (GO:0042274)	4.69069721
12	negative regulation of astrocyte differentiation (GO:0048712)	4.58730793
13	positive regulation of megakaryocyte differentiation (GO:0045654)	4.57861845
14	viral transcription (GO:0019083)	4.54302263
15	translational termination (GO:0006415)	4.36822014
16	radial glial cell differentiation (GO:0060019)	4.00531601
17	maturation of SSU-rRNA (GO:0030490)	4.00431257
18	pattern specification involved in kidney development (GO:0061004)	3.91638561
19	chaperone-mediated protein complex assembly (GO:0051131)	3.87311001
20	inner ear receptor cell differentiation (GO:0060113)	3.80770314
21	neurotransmitter catabolic process (GO:0042135)	3.78491811
22	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.78076943
23	ribosomal small subunit assembly (GO:0000028)	3.72019992
24	neurotransmitter-gated ion channel clustering (GO:0072578)	3.69356647
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.66047618
26	translational elongation (GO:0006414)	3.66043691
27	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.63549548
28	nephron tubule morphogenesis (GO:0072078)	3.62565963
29	nephron epithelium morphogenesis (GO:0072088)	3.62565963
30	spinal cord motor neuron differentiation (GO:0021522)	3.60958743
31	cotranslational protein targeting to membrane (GO:0006613)	3.58719482
32	protein targeting to ER (GO:0045047)	3.56103562
33	purine nucleotide salvage (GO:0032261)	3.54356724
34	seminiferous tubule development (GO:0072520)	3.52562367
35	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.48705266
36	ncRNA 3-end processing (GO:0043628)	3.46758128
37	regulation of action potential (GO:0098900)	3.45096225
38	hair cell differentiation (GO:0035315)	3.44136173
39	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.41662565
40	viral life cycle (GO:0019058)	3.41297266
41	substrate-independent telencephalic tangential migration (GO:0021826)	3.41061365
42	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.41061365
43	protein localization to endoplasmic reticulum (GO:0070972)	3.39433708
44	fucose metabolic process (GO:0006004)	3.39263019
45	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.32203843
46	GMP metabolic process (GO:0046037)	3.31570680
47	synaptic transmission, cholinergic (GO:0007271)	3.30854642
48	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.30162244
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.29899805
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.29899805
51	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.29589210
52	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.29475757
53	telencephalon development (GO:0021537)	3.28460122
54	cellular protein complex disassembly (GO:0043624)	3.28364919
55	adult walking behavior (GO:0007628)	3.25132413
56	cell proliferation in forebrain (GO:0021846)	3.23084390
57	tongue development (GO:0043586)	3.14322290
58	positive regulation of gastrulation (GO:2000543)	3.12636450
59	cell differentiation in spinal cord (GO:0021515)	3.09763371
60	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.03203290
61	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.01563992
62	auditory behavior (GO:0031223)	2.99667169
63	ribosomal large subunit biogenesis (GO:0042273)	2.99249173
64	astrocyte differentiation (GO:0048708)	2.97798190
65	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.97334246
66	uterus development (GO:0060065)	2.96386989
67	N-glycan processing (GO:0006491)	2.95570735
68	negative regulation of glial cell differentiation (GO:0045686)	2.93604522
69	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92421868
70	ATP synthesis coupled proton transport (GO:0015986)	2.92421868
71	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.91642620
72	regulation of cilium movement (GO:0003352)	2.91631179
73	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.91451848
74	fucosylation (GO:0036065)	2.85951080
75	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.85698033
76	regulation of Rac protein signal transduction (GO:0035020)	2.82581007
77	axoneme assembly (GO:0035082)	2.82119513
78	short-term memory (GO:0007614)	2.79320033
79	translational initiation (GO:0006413)	2.78583092
80	purine nucleobase biosynthetic process (GO:0009113)	2.78247978
81	regulation of astrocyte differentiation (GO:0048710)	2.78161484
82	DNA replication checkpoint (GO:0000076)	2.77138749
83	water-soluble vitamin biosynthetic process (GO:0042364)	2.75050950
84	replication fork processing (GO:0031297)	2.75038083
85	mechanosensory behavior (GO:0007638)	2.75019824
86	specification of organ identity (GO:0010092)	2.73314348
87	positive regulation of action potential (GO:0045760)	2.72626049
88	presynaptic membrane organization (GO:0097090)	2.72218190
89	epithelial cilium movement (GO:0003351)	2.70255039
90	presynaptic membrane assembly (GO:0097105)	2.70080203
91	behavioral response to ethanol (GO:0048149)	2.69728843
92	purine-containing compound salvage (GO:0043101)	2.69411602
93	retinal cone cell development (GO:0046549)	2.69089158
94	protein complex disassembly (GO:0043241)	2.69004843
95	heart field specification (GO:0003128)	2.68507338
96	secondary heart field specification (GO:0003139)	2.68507338
97	postsynaptic membrane organization (GO:0001941)	2.67574522
98	neuronal action potential propagation (GO:0019227)	2.64752987
99	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.63766329
100	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62333150

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.95125946
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.41983330
3	EZH2_22144423_ChIP-Seq_EOC_Human	5.18251730
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.07044571
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.85781445
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52309302
7	VDR_22108803_ChIP-Seq_LS180_Human	2.44650081
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.30065606
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.29323490
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.24245204
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.20199307
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97285237
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.97153775
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95615925
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.92446110
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.92394284
17	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73793154
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.70990477
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68553788
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67815256
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.67478241
22	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.67478241
23	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.67281617
24	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.63706778
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.62735484
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.62544176
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.47514698
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.44909818
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.43070316
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42330897
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36375304
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36375304
33	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.34210147
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.33755278
35	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.33696769
36	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.29734690
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29620321
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29519951
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29442849
40	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.28286057
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26847742
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26790408
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26671089
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26495961
45	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.25194361
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25169381
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.24628589
48	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.23730033
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.22999127
50	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.22183011
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.22044296
52	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21993994
53	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21899067
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.18997598
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.17637348
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.16369738
57	FUS_26573619_Chip-Seq_HEK293_Human	1.13605110
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.13402147
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12504142
60	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.11000359
61	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.10671121
62	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10464709
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10451235
64	P300_19829295_ChIP-Seq_ESCs_Human	1.09128642
65	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09060554
66	EWS_26573619_Chip-Seq_HEK293_Human	1.08449310
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.08247908
68	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.05370555
69	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04475417
70	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03574649
71	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02588591
72	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.02056727
73	CTCF_27219007_Chip-Seq_Bcells_Human	1.00715407
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00076594
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99839555
76	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.99382295
77	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98915349
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.95402658
79	CIITA_25753668_ChIP-Seq_RAJI_Human	0.94529205
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92478411
81	TP53_22573176_ChIP-Seq_HFKS_Human	0.91501203
82	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.89810189
83	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.88659842
84	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.88058813
85	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.87565026
86	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87062535
87	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.86519929
88	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.85402195
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.85200586
90	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.85118316
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.83628717
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82873436
93	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.82356861
94	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.81811929
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81322470
96	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.81054671
97	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.80932127
98	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.80899074
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.79285932
100	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.79277306

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.53612960
2	MP0003787_abnormal_imprinting	4.85038380
3	MP0003123_paternal_imprinting	3.98060218
4	MP0009379_abnormal_foot_pigmentation	3.09530290
5	MP0003890_abnormal_embryonic-extraembry	3.03325542
6	MP0005394_taste/olfaction_phenotype	2.95340802
7	MP0005499_abnormal_olfactory_system	2.95340802
8	MP0008789_abnormal_olfactory_epithelium	2.78918700
9	MP0002163_abnormal_gland_morphology	2.69796965
10	MP0009053_abnormal_anal_canal	2.32499879
11	MP0003121_genomic_imprinting	2.32176635
12	MP0001293_anophthalmia	2.11619472
13	MP0002638_abnormal_pupillary_reflex	2.06140260
14	MP0000049_abnormal_middle_ear	2.01828114
15	MP0000778_abnormal_nervous_system	1.99773956
16	MP0002938_white_spotting	1.99612893
17	MP0002837_dystrophic_cardiac_calcinosis	1.85900279
18	MP0001529_abnormal_vocalization	1.83193228
19	MP0001968_abnormal_touch/_nociception	1.79524549
20	MP0003880_abnormal_central_pattern	1.75767198
21	MP0002653_abnormal_ependyma_morphology	1.73505548
22	MP0003119_abnormal_digestive_system	1.61412427
23	MP0000631_abnormal_neuroendocrine_gland	1.53307182
24	MP0002734_abnormal_mechanical_nocicepti	1.51435905
25	MP0006276_abnormal_autonomic_nervous	1.49104091
26	MP0005551_abnormal_eye_electrophysiolog	1.45204019
27	MP0002735_abnormal_chemical_nociception	1.43747502
28	MP0005379_endocrine/exocrine_gland_phen	1.42665797
29	MP0002822_catalepsy	1.38911279
30	MP0002249_abnormal_larynx_morphology	1.37773087
31	MP0003879_abnormal_hair_cell	1.37189060
32	MP0005195_abnormal_posterior_eye	1.37127863
33	MP0010030_abnormal_orbit_morphology	1.37029831
34	MP0003136_yellow_coat_color	1.32849477
35	MP0003646_muscle_fatigue	1.31427150
36	MP0003122_maternal_imprinting	1.31181288
37	MP0000372_irregular_coat_pigmentation	1.27699922
38	MP0002272_abnormal_nervous_system	1.27500596
39	MP0005423_abnormal_somatic_nervous	1.25613477
40	MP0002736_abnormal_nociception_after	1.25074179
41	MP0000026_abnormal_inner_ear	1.24655920
42	MP0001485_abnormal_pinna_reflex	1.24528286
43	MP0002234_abnormal_pharynx_morphology	1.23745291
44	MP0001286_abnormal_eye_development	1.20873290
45	MP0002102_abnormal_ear_morphology	1.19538280
46	MP0000566_synostosis	1.18083268
47	MP0003942_abnormal_urinary_system	1.17679905
48	MP0002752_abnormal_somatic_nervous	1.16987115
49	MP0002184_abnormal_innervation	1.16534416
50	MP0001919_abnormal_reproductive_system	1.14599443
51	MP0004142_abnormal_muscle_tone	1.13624589
52	MP0005646_abnormal_pituitary_gland	1.11480849
53	MP0002909_abnormal_adrenal_gland	1.06485031
54	MP0006072_abnormal_retinal_apoptosis	1.06243079
55	MP0004185_abnormal_adipocyte_glucose	1.05420111
56	MP0005389_reproductive_system_phenotype	1.05145804
57	MP0001963_abnormal_hearing_physiology	1.00011489
58	MP0003937_abnormal_limbs/digits/tail_de	0.99360865
59	MP0002876_abnormal_thyroid_physiology	0.97972255
60	MP0002751_abnormal_autonomic_nervous	0.94926216
61	MP0008877_abnormal_DNA_methylation	0.94708742
62	MP0002557_abnormal_social/conspecific_i	0.94312527
63	MP0004133_heterotaxia	0.93457205
64	MP0001970_abnormal_pain_threshold	0.91936858
65	MP0000427_abnormal_hair_cycle	0.91848667
66	MP0002882_abnormal_neuron_morphology	0.91713356
67	MP0001984_abnormal_olfaction	0.91096989
68	MP0002092_abnormal_eye_morphology	0.90955729
69	MP0000579_abnormal_nail_morphology	0.90693264
70	MP0003635_abnormal_synaptic_transmissio	0.90138550
71	MP0009250_abnormal_appendicular_skeleto	0.89629902
72	MP0003938_abnormal_ear_development	0.89356813
73	MP0008995_early_reproductive_senescence	0.87457018
74	MP0001986_abnormal_taste_sensitivity	0.87393100
75	MP0000955_abnormal_spinal_cord	0.86299697
76	MP0003011_delayed_dark_adaptation	0.83293113
77	MP0003755_abnormal_palate_morphology	0.81966964
78	MP0002152_abnormal_brain_morphology	0.81827084
79	MP0005391_vision/eye_phenotype	0.80875653
80	MP0003693_abnormal_embryo_hatching	0.80705819
81	MP0001756_abnormal_urination	0.80086817
82	MP0003385_abnormal_body_wall	0.79372264
83	MP0002160_abnormal_reproductive_system	0.78697675
84	MP0001324_abnormal_eye_pigmentation	0.78202697
85	MP0004924_abnormal_behavior	0.77908915
86	MP0005386_behavior/neurological_phenoty	0.77908915
87	MP0009745_abnormal_behavioral_response	0.77812478
88	MP0002095_abnormal_skin_pigmentation	0.76976958
89	MP0008004_abnormal_stomach_pH	0.74444636
90	MP0002233_abnormal_nose_morphology	0.73943637
91	MP0002572_abnormal_emotion/affect_behav	0.72810998
92	MP0002733_abnormal_thermal_nociception	0.71928374
93	MP0001188_hyperpigmentation	0.70717376
94	MP0003861_abnormal_nervous_system	0.70016565
95	MP0002229_neurodegeneration	0.69531520
96	MP0002063_abnormal_learning/memory/cond	0.69433567
97	MP0003195_calcinosis	0.68852821
98	MP0002697_abnormal_eye_size	0.68617636
99	MP0002064_seizures	0.66641905
100	MP0002067_abnormal_sensory_capabilities	0.64851029

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	3.86355833
2	Myelomeningocele (HP:0002475)	3.63485978
3	Nephronophthisis (HP:0000090)	3.56455803
4	Pancreatic fibrosis (HP:0100732)	3.53336488
5	Adrenal hypoplasia (HP:0000835)	3.38810173
6	Hepatoblastoma (HP:0002884)	3.36130586
7	Rib fusion (HP:0000902)	3.30838135
8	Diastasis recti (HP:0001540)	3.27273096
9	Enlarged kidneys (HP:0000105)	3.24424875
10	Abnormality of midbrain morphology (HP:0002418)	3.17740333
11	Molar tooth sign on MRI (HP:0002419)	3.17740333
12	Pancreatic cysts (HP:0001737)	3.14317226
13	Concave nail (HP:0001598)	3.06903454
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.02827630
15	Disproportionate short-trunk short stature (HP:0003521)	3.01379518
16	Hyperventilation (HP:0002883)	2.97761534
17	Reticulocytopenia (HP:0001896)	2.92766889
18	Neoplasm of the adrenal cortex (HP:0100641)	2.90535331
19	Cystic liver disease (HP:0006706)	2.84126754
20	Porencephaly (HP:0002132)	2.80623219
21	Microretrognathia (HP:0000308)	2.79680546
22	Meningocele (HP:0002435)	2.79430934
23	Abnormal number of erythroid precursors (HP:0012131)	2.66976957
24	Facial hemangioma (HP:0000329)	2.63632314
25	Deep palmar crease (HP:0006191)	2.60322760
26	Abdominal situs inversus (HP:0003363)	2.58583090
27	Abnormality of abdominal situs (HP:0011620)	2.58583090
28	Abnormal pancreas size (HP:0012094)	2.57930737
29	Drooling (HP:0002307)	2.56028276
30	Abnormality of the aortic arch (HP:0012303)	2.51073944
31	Congenital hepatic fibrosis (HP:0002612)	2.50217922
32	Abnormality of the renal medulla (HP:0100957)	2.49648441
33	Bifid tongue (HP:0010297)	2.47582945
34	Posterior subcapsular cataract (HP:0007787)	2.47473284
35	True hermaphroditism (HP:0010459)	2.47072573
36	Acute necrotizing encephalopathy (HP:0006965)	2.42846857
37	Acute encephalopathy (HP:0006846)	2.42230502
38	Median cleft lip (HP:0000161)	2.41493576
39	Type II lissencephaly (HP:0007260)	2.40578904
40	Broad alveolar ridges (HP:0000187)	2.39753119
41	Mitochondrial inheritance (HP:0001427)	2.39639542
42	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.38818809
43	Asplenia (HP:0001746)	2.37386923
44	Broad-based gait (HP:0002136)	2.36143587
45	Septo-optic dysplasia (HP:0100842)	2.35380404
46	Excessive salivation (HP:0003781)	2.35168803
47	Horseshoe kidney (HP:0000085)	2.32947073
48	Cortical dysplasia (HP:0002539)	2.31806912
49	Macrocytic anemia (HP:0001972)	2.31787779
50	Abnormal number of incisors (HP:0011064)	2.30139852
51	Preaxial hand polydactyly (HP:0001177)	2.28977344
52	Abnormal mitochondria in muscle tissue (HP:0008316)	2.19576212
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.16186047
54	Absent/shortened dynein arms (HP:0200106)	2.16186047
55	Abnormality of alanine metabolism (HP:0010916)	2.13485494
56	Hyperalaninemia (HP:0003348)	2.13485494
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13485494
58	Hyperglycinemia (HP:0002154)	2.10876333
59	Increased CSF lactate (HP:0002490)	2.08603194
60	Poor suck (HP:0002033)	2.07800660
61	Narrow forehead (HP:0000341)	2.07422413
62	Sclerocornea (HP:0000647)	2.02776004
63	Tubular atrophy (HP:0000092)	2.02522182
64	Abnormal rod and cone electroretinograms (HP:0008323)	2.00507470
65	Neonatal hypoglycemia (HP:0001998)	1.99574727
66	Hepatocellular necrosis (HP:0001404)	1.99286846
67	Abnormal drinking behavior (HP:0030082)	1.99027233
68	Polydipsia (HP:0001959)	1.99027233
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98666972
70	Medial flaring of the eyebrow (HP:0010747)	1.97257128
71	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.96606313
72	Increased number of teeth (HP:0011069)	1.96308070
73	Dandy-Walker malformation (HP:0001305)	1.94630796
74	Macroglossia (HP:0000158)	1.94096559
75	Protruding tongue (HP:0010808)	1.93530221
76	Broad distal phalanx of finger (HP:0009836)	1.93241557
77	3-Methylglutaconic aciduria (HP:0003535)	1.90862255
78	Cerebellar dysplasia (HP:0007033)	1.90475275
79	Anencephaly (HP:0002323)	1.89333829
80	Amblyopia (HP:0000646)	1.87710781
81	Postaxial foot polydactyly (HP:0001830)	1.84594116
82	Renal hypoplasia (HP:0000089)	1.84532447
83	Severe muscular hypotonia (HP:0006829)	1.83328562
84	Anophthalmia (HP:0000528)	1.82814220
85	Pendular nystagmus (HP:0012043)	1.82443713
86	Pachygyria (HP:0001302)	1.79088708
87	Depressed nasal ridge (HP:0000457)	1.78554584
88	Growth hormone deficiency (HP:0000824)	1.77953201
89	Neoplasm of the adrenal gland (HP:0100631)	1.77475449
90	Volvulus (HP:0002580)	1.76851996
91	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.75883986
92	Hypoplasia of the brainstem (HP:0002365)	1.75883986
93	Progressive macrocephaly (HP:0004481)	1.75354922
94	Absent thumb (HP:0009777)	1.73500307
95	Hepatic necrosis (HP:0002605)	1.73117628
96	Embryonal renal neoplasm (HP:0011794)	1.72510041
97	Cerebral edema (HP:0002181)	1.71533603
98	Optic nerve coloboma (HP:0000588)	1.70946247
99	Ectopic kidney (HP:0000086)	1.69864957
100	Missing ribs (HP:0000921)	1.69752635

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.50390083
2	BMPR1B	4.09458685
3	WNK4	3.74514099
4	ACVR1B	3.49192415
5	WNK3	2.96440847
6	PDK2	2.71884514
7	TNIK	2.38063969
8	TLK1	2.16318184
9	NTRK2	2.15670912
10	BRAF	2.13813843
11	PLK4	1.93387240
12	BCKDK	1.84243058
13	NME2	1.75217755
14	MAP3K11	1.70383518
15	DYRK2	1.70135372
16	BRSK1	1.68227319
17	MKNK2	1.68030122
18	CAMKK2	1.61605858
19	LRRK2	1.52020780
20	CAMKK1	1.51532657
21	SGK494	1.50727213
22	SGK223	1.50727213
23	TGFBR1	1.49458714
24	TYRO3	1.47941429
25	MAP4K2	1.44813617
26	ABL2	1.37252856
27	EPHB2	1.29146595
28	SGK2	1.26664124
29	CDK19	1.26371223
30	PRKCG	1.22529076
31	MAPK13	1.18028839
32	STK39	1.15551572
33	BUB1	1.15399825
34	GRK1	1.15166414
35	FRK	1.06624075
36	BRSK2	1.03789281
37	ZAK	0.99615338
38	PRKD3	0.99211839
39	OXSR1	0.98852761
40	WNK1	0.97577666
41	KSR1	0.95794847
42	MKNK1	0.93133750
43	NME1	0.90845158
44	IRAK2	0.90309618
45	PLK1	0.85628557
46	ADRBK2	0.82971779
47	MARK1	0.80579317
48	ADRBK1	0.79425812
49	MARK3	0.76031151
50	PRKCH	0.74848928
51	MAP2K7	0.74277091
52	CDC7	0.70174601
53	FLT3	0.69935992
54	NUAK1	0.67069567
55	STK16	0.66978565
56	MAP3K4	0.66173500
57	PRKCQ	0.65539298
58	AURKA	0.65348137
59	RPS6KA4	0.64444996
60	PASK	0.63353055
61	RPS6KA2	0.62544238
62	STK38L	0.60505824
63	LIMK1	0.59245613
64	PRKCI	0.58543006
65	PINK1	0.57332484
66	CSNK2A2	0.55565774
67	STK11	0.55531382
68	PRKACA	0.52809826
69	STK10	0.52282145
70	DYRK3	0.52135866
71	MAP2K2	0.52060505
72	CSNK1E	0.51900192
73	SGK3	0.51874533
74	PRKCZ	0.51738520
75	DAPK2	0.49631854
76	MAP3K8	0.47884016
77	MAPKAPK3	0.47607703
78	PAK3	0.47351653
79	ICK	0.47236293
80	CSF1R	0.40984164
81	CSNK2A1	0.40917886
82	RPS6KA6	0.40058490
83	CCNB1	0.37113317
84	CAMK1	0.36198017
85	GRK7	0.35923283
86	CAMK1D	0.35897369
87	PRKD2	0.33917768
88	NTRK1	0.33208659
89	TEC	0.32539793
90	DAPK3	0.31171631
91	PRKCE	0.30482972
92	MAP3K9	0.28895888
93	PKN2	0.28248566
94	RPS6KC1	0.27991694
95	RPS6KL1	0.27991694
96	PRKCA	0.27929860
97	AKT1	0.25827918
98	IRAK3	0.24873261
99	SRPK1	0.24857604
100	ILK	0.24847513

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.20184233
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.59095219
3	Parkinsons disease_Homo sapiens_hsa05012	3.14082976
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.59733619
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.54746232
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.50325272
7	Nicotine addiction_Homo sapiens_hsa05033	2.42471978
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39044830
9	RNA polymerase_Homo sapiens_hsa03020	2.15707507
10	Huntingtons disease_Homo sapiens_hsa05016	2.11273653
11	Alzheimers disease_Homo sapiens_hsa05010	2.04462443
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.04350269
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.04285247
14	Protein export_Homo sapiens_hsa03060	1.99540397
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94349047
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.92606103
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89747553
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84258874
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.82181932
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72824308
21	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.68881725
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.68086346
23	Propanoate metabolism_Homo sapiens_hsa00640	1.61342851
24	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.54640761
25	Homologous recombination_Homo sapiens_hsa03440	1.54000812
26	Peroxisome_Homo sapiens_hsa04146	1.49202224
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48299268
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38685547
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38226448
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35019896
31	Butanoate metabolism_Homo sapiens_hsa00650	1.33389531
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26040830
33	Fat digestion and absorption_Homo sapiens_hsa04975	1.21503243
34	Phototransduction_Homo sapiens_hsa04744	1.19577359
35	RNA degradation_Homo sapiens_hsa03018	1.17002160
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14246013
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09149764
38	Proteasome_Homo sapiens_hsa03050	1.00998558
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.99319149
40	Metabolic pathways_Homo sapiens_hsa01100	0.96621352
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.96192421
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93169900
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90997578
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.85812563
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.85316681
46	Olfactory transduction_Homo sapiens_hsa04740	0.85167304
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84838398
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84561365
49	Spliceosome_Homo sapiens_hsa03040	0.81355495
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81297712
51	Purine metabolism_Homo sapiens_hsa00230	0.81209895
52	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.80664059
53	Axon guidance_Homo sapiens_hsa04360	0.80217945
54	Insulin secretion_Homo sapiens_hsa04911	0.79996311
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76362170
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.71846359
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.71198711
58	Morphine addiction_Homo sapiens_hsa05032	0.70988022
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70889591
60	One carbon pool by folate_Homo sapiens_hsa00670	0.70534358
61	Fatty acid elongation_Homo sapiens_hsa00062	0.68109250
62	Sulfur metabolism_Homo sapiens_hsa00920	0.68063793
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67630458
64	RNA transport_Homo sapiens_hsa03013	0.67491453
65	Fatty acid degradation_Homo sapiens_hsa00071	0.66931161
66	Notch signaling pathway_Homo sapiens_hsa04330	0.65906599
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65141016
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.62682244
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61420126
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.59435605
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59009780
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57808298
73	Base excision repair_Homo sapiens_hsa03410	0.57289128
74	Basal transcription factors_Homo sapiens_hsa03022	0.56181880
75	Regulation of autophagy_Homo sapiens_hsa04140	0.53491724
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53025548
77	Mismatch repair_Homo sapiens_hsa03430	0.52829735
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52290722
79	Retinol metabolism_Homo sapiens_hsa00830	0.52020766
80	Glutathione metabolism_Homo sapiens_hsa00480	0.51416943
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.50702050
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.47538788
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47411713
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.46996427
85	Folate biosynthesis_Homo sapiens_hsa00790	0.46556452
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44500274
87	Circadian entrainment_Homo sapiens_hsa04713	0.42285112
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41955407
89	Other glycan degradation_Homo sapiens_hsa00511	0.41379558
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.38785775
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37734735
92	GABAergic synapse_Homo sapiens_hsa04727	0.37725137
93	Cholinergic synapse_Homo sapiens_hsa04725	0.34813551
94	Serotonergic synapse_Homo sapiens_hsa04726	0.30495756
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30068024
96	Sulfur relay system_Homo sapiens_hsa04122	0.29897317
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27577524
98	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27192180
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26868821
100	ABC transporters_Homo sapiens_hsa02010	0.25591007

TOP3BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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